SEQUENCE LISTING

<110> Hyseq, Inc

<120>  NOVEL NUCLEIC ACIDS AND POLYPEPTIDES

<130>  21272-115/ 785

<140>  NOT YET ASSIGNED
<141>  2001-10-11

<150>  09/687,527
<151>  2000-10-12

<160>  892   

<170>  Custom


      <210> 1
      <211> 867
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(461)

      <400> 1
 gaaggggagt ggaaggcagg ggctgaagac acaggccagg cgga atg aag atg atg      56
                                                  Met Lys Met Met
                                                    1

 gtg gtc ttg ctt atg ctg tcc tcg ctc agc cgg ctc ctg ggc ctc atg      104
 Val Val Leu Leu Met Leu Ser Ser Leu Ser Arg Leu Leu Gly Leu Met
   5                  10                  15                  20

 agg cca tca tct ctc agg caa tac ctg gac tct gtg ccc ttg cca ccc      152
 Arg Pro Ser Ser Leu Arg Gln Tyr Leu Asp Ser Val Pro Leu Pro Pro
                  25                  30                  35

 tgc cag gag caa cag cca aag gct agt gcc gag cta gac cac aag gcc      200
 Cys Gln Glu Gln Gln Pro Lys Ala Ser Ala Glu Leu Asp His Lys Ala
              40                  45                  50

 tgc tac ctg tgc cac agc ttg ctg atg ctg gcc ggg gta gtt gtt agc      248
 Cys Tyr Leu Cys His Ser Leu Leu Met Leu Ala Gly Val Val Val Ser
          55                  60                  65

 tgc cag gac atc act cca gac cag tgg ggc gag ctg cag ctg ctg tgc      296
 Cys Gln Asp Ile Thr Pro Asp Gln Trp Gly Glu Leu Gln Leu Leu Cys
      70                  75                  80

 atg cag ttg gac cgc cac atc agc acg cag atc cgg gag agc ccc cag      344
 Met Gln Leu Asp Arg His Ile Ser Thr Gln Ile Arg Glu Ser Pro Gln
  85                  90                  95                 100

 gcc atg cac cgc acc atg ctc aag gac ctg gct acc cag acc tac atc      392
 Ala Met His Arg Thr Met Leu Lys Asp Leu Ala Thr Gln Thr Tyr Ile
                 105                 110                 115

 cgt tgg cag gag ctg ctg acc cac tgc cag ccc cag gcc cag tat ttc      440
 Arg Trp Gln Glu Leu Leu Thr His Cys Gln Pro Gln Ala Gln Tyr Phe
             120                 125                 130

 agc ccc tgg aaa gac atc taa ag ggacagggtc agggcagccc agggctcctg      493
 Ser Pro Trp Lys Asp Ile 
         135

 gcttcagcag gaagtgaaca ggctcaggga actggaggaa gcgaagcatc aaggccagag    553

 gaggccacat gctgaccagc ctgatgaggc aagagcctgc ccctgccacc gccccgaccc    613

 ctctcctctc tgcaagagcc tgcctctgcc accgccccga ccccctctcc tctcagcaag    673

 ggatgggcct ctctgcctcg cccacccctc agccctcctc ccagccatct cctcttccct    733

 aaggcctctg tctccatagc tctggtttcc ctgggcctca gtcctcccca ccctccttcc    793

 tctgtctccc tgtcactaat gtgaggtttc tttgtgcaca ttaaagtctt ctttcagcat    853

 caaaaaaaaa aaaa                                                      867




      <210> 2
      <211> 756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (31)..(474)

      <400> 2
 cccctcgagg gatactctag agcggccgcc     atg gcg gac agc ggc acc gcg      51
                                      Met Ala Asp Ser Gly Thr Ala
                                        1               5

 ggg ggc gcg gcg ttg gcg gcc ccg gcc ccc ggg ccg ggc agt ggc ggc       99
 Gly Gly Ala Ala Leu Ala Ala Pro Ala Pro Gly Pro Gly Ser Gly Gly
          10                  15                  20

 cca gga cca cgc gtc tac ttt cag agc ccc ccc ggg gcc gca gga gag      147
 Pro Gly Pro Arg Val Tyr Phe Gln Ser Pro Pro Gly Ala Ala Gly Glu
      25                  30                  35

 ggc ccg ggc ggg gcg gac gat gag ggc cca gtg agg cgc caa ggg aag      195
 Gly Pro Gly Gly Ala Asp Asp Glu Gly Pro Val Arg Arg Gln Gly Lys
  40                  45                  50                  55

 gtc acc gtc aag tat gac cgc aag gag cta cgg aag cgc ctc aac cta      243
 Val Thr Val Lys Tyr Asp Arg Lys Glu Leu Arg Lys Arg Leu Asn Leu
                  60                  65                  70

 gag gag tgg atc ctg gag cag ctc acg cgc ctc tac gac tgc cag gaa      291
 Glu Glu Trp Ile Leu Glu Gln Leu Thr Arg Leu Tyr Asp Cys Gln Glu
              75                  80                  85

 gag gag atc cca gaa ctg gag att gac gtg gat gag ctc ctg gac atg      339
 Glu Glu Ile Pro Glu Leu Glu Ile Asp Val Asp Glu Leu Leu Asp Met
          90                  95                 100

 gag agt gac gat gcc cgg gct gcc agg gtc aag gag ctg ctg gtt gac      387
 Glu Ser Asp Asp Ala Arg Ala Ala Arg Val Lys Glu Leu Leu Val Asp
     105                 110                 115

 tgt tac aaa ccc aca gag gcc ttc att tct ggc ctg ctg gac aag atc      435
 Cys Tyr Lys Pro Thr Glu Ala Phe Ile Ser Gly Leu Leu Asp Lys Ile
 120                 125                 130                 135

 cgg ggc atg cag aag ctg agc aca ccc cag aag aag tga gggtccccga       484
 Arg Gly Met Gln Lys Leu Ser Thr Pro Gln Lys Lys 
                 140                 145

 cccaggagaa cggtggctcc cacaggacaa tcgctgcccc ccaacctcgt agcaacagca    544

 ataccggggg accctgcggc caggcctggt gccatgagca gggctcctcg tgcccctggc    604

 ccaggggtct cttcccctgc cccctcagtt ttccactttt ggggtttttt attgttatta    664

 aactgatggg actttttgtg tttttatatt gactctgcgg cgcgggccct ttaataaagc    724

 taggatacgc ctttggtgca gctaaaaaaa aa                                  756




      <210> 3
      <211> 2591
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(1587)

      <400> 3
 gcgcagcggc ggcagcggag agcgagagag gggagcaggc ttctaaccct cctttatgtg     60

 actcagagaa aggagacctc attccaagtt ccaggattaa ttctgatgaa agtattctgt    120

 ctcatgcatc taatacttta cttgtgaatg aagattcatt atgaggtgct atacgtggat    180

 gacctgctta gttttaattt ttggagaaat acattttata aaacattttc atcagattgc    240

 taaaattgtg ccacttgaag a  atg gat gat gat gat ttt ggt ggt ttt gag     291
                          Met Asp Asp Asp Asp Phe Gly Gly Phe Glu
                            1               5                  10

 gct gcg gag act ttt gat ggt gga agt ggt gaa acc caa aca aca tct      339
 Ala Ala Glu Thr Phe Asp Gly Gly Ser Gly Glu Thr Gln Thr Thr Ser
                  15                  20                  25

 cct gct att cct tgg gct gcc ttt cct gca gta tct gga gtc cat ctt      387
 Pro Ala Ile Pro Trp Ala Ala Phe Pro Ala Val Ser Gly Val His Leu
              30                  35                  40

 tca cca tct tct cct gag att gta ctg gac cgt gac cac tct tct tcc      435
 Ser Pro Ser Ser Pro Glu Ile Val Leu Asp Arg Asp His Ser Ser Ser
          45                  50                  55

 att ggc tgc ctc tct tct gat gcc att att tca tca cca gag aat aca      483
 Ile Gly Cys Leu Ser Ser Asp Ala Ile Ile Ser Ser Pro Glu Asn Thr
      60                  65                  70

 cat gca gca aat agc att gtg agt caa act att cca aaa gca cag att      531
 His Ala Ala Asn Ser Ile Val Ser Gln Thr Ile Pro Lys Ala Gln Ile
  75                  80                  85                  90

 cag caa tca aca cac act cat ctg gat atc tca ctt ttt cca ttg ggt      579
 Gln Gln Ser Thr His Thr His Leu Asp Ile Ser Leu Phe Pro Leu Gly
                  95                 100                 105

 tta act gat gaa aaa agt aat gga aca att gcc ctt gtg gat gat tct      627
 Leu Thr Asp Glu Lys Ser Asn Gly Thr Ile Ala Leu Val Asp Asp Ser
             110                 115                 120

 gag gat cct gga gcc aat gta tct aac ata cag ctt cag caa aaa att      675
 Glu Asp Pro Gly Ala Asn Val Ser Asn Ile Gln Leu Gln Gln Lys Ile
         125                 130                 135

 tca agt ctg gag att aaa ctc aaa gta tct gaa gaa gaa aaa cag aga      723
 Ser Ser Leu Glu Ile Lys Leu Lys Val Ser Glu Glu Glu Lys Gln Arg
     140                 145                 150

 att aaa cag gat gtg gaa tca ttg atg gaa aag cat aat gtc tta gaa      771
 Ile Lys Gln Asp Val Glu Ser Leu Met Glu Lys His Asn Val Leu Glu
 155                 160                 165                 170

 aaa ggc ttt cta aaa gaa aaa gag caa gag gcc att tct ttt caa gat      819
 Lys Gly Phe Leu Lys Glu Lys Glu Gln Glu Ala Ile Ser Phe Gln Asp
                 175                 180                 185

 aga tac aaa gaa ctt cag gaa aaa cat aaa caa gaa ttg gaa gac atg      867
 Arg Tyr Lys Glu Leu Gln Glu Lys His Lys Gln Glu Leu Glu Asp Met
             190                 195                 200

 agg aaa gct ggt cac gaa gcc ctc agc att att gtg gat gaa tat aag      915
 Arg Lys Ala Gly His Glu Ala Leu Ser Ile Ile Val Asp Glu Tyr Lys
         205                 210                 215

 gca cta ctg cag tct tca gtt aag caa caa gta gaa gct att gaa aaa      963
 Ala Leu Leu Gln Ser Ser Val Lys Gln Gln Val Glu Ala Ile Glu Lys
     220                 225                 230

 cag tac att tct gca att gag aaa cag gca cac aag tgt gag gag ttg     1011
 Gln Tyr Ile Ser Ala Ile Glu Lys Gln Ala His Lys Cys Glu Glu Leu
 235                 240                 245                 250

 cta aat gct cag cat cag agg ctc ctt gaa atg cta gat aca gag aag     1059
 Leu Asn Ala Gln His Gln Arg Leu Leu Glu Met Leu Asp Thr Glu Lys
                 255                 260                 265

 gaa ctg tta aaa gaa aaa ata aag gaa gct ttg att cag caa tct caa     1107
 Glu Leu Leu Lys Glu Lys Ile Lys Glu Ala Leu Ile Gln Gln Ser Gln
             270                 275                 280

 gaa cag aag gaa ata ttg gaa aag tgt ttg gag gaa gaa agg caa aga     1155
 Glu Gln Lys Glu Ile Leu Glu Lys Cys Leu Glu Glu Glu Arg Gln Arg
         285                 290                 295

 aat aaa gag gca tta gta tcc gct gca aag ctt gaa aaa gaa gca gtg     1203
 Asn Lys Glu Ala Leu Val Ser Ala Ala Lys Leu Glu Lys Glu Ala Val
     300                 305                 310

 aag gat gca gtt tta aaa gtc gta gaa gaa gaa aga aaa aat tta gaa     1251
 Lys Asp Ala Val Leu Lys Val Val Glu Glu Glu Arg Lys Asn Leu Glu
 315                 320                 325                 330

 aaa gcg cat gct gaa gaa agg gaa tta tgg aag aca gaa cat gca aaa     1299
 Lys Ala His Ala Glu Glu Arg Glu Leu Trp Lys Thr Glu His Ala Lys
                 335                 340                 345

 gat caa gaa aaa gta tct cag gaa att caa aaa gct ata caa gaa caa     1347
 Asp Gln Glu Lys Val Ser Gln Glu Ile Gln Lys Ala Ile Gln Glu Gln
             350                 355                 360

 aga aaa ata agt cag gaa act gtt aag gca gca ata ata gaa gag cag     1395
 Arg Lys Ile Ser Gln Glu Thr Val Lys Ala Ala Ile Ile Glu Glu Gln
         365                 370                 375

 aaa cga agt gaa aag gct gtg gaa gag gca gtg aaa aga aca aga gat     1443
 Lys Arg Ser Glu Lys Ala Val Glu Glu Ala Val Lys Arg Thr Arg Asp
     380                 385                 390

 gaa ttg ata gag tat ata aaa gaa cag aaa agg ctc gat caa gtc atc     1491
 Glu Leu Ile Glu Tyr Ile Lys Glu Gln Lys Arg Leu Asp Gln Val Ile
 395                 400                 405                 410

 cgc caa aga agc ctg tcc agt ttg gaa ctg ttc ctc tcc tgt gca cag     1539
 Arg Gln Arg Ser Leu Ser Ser Leu Glu Leu Phe Leu Ser Cys Ala Gln
                 415                 420                 425

 aaa cag tta agt gct tta ata gct acg gaa cca gtt gac att gaa taa     1587
 Lys Gln Leu Ser Ala Leu Ile Ala Thr Glu Pro Val Asp Ile Glu 
             430                 435                 440

 aaagaacatg acaaacccac actggcattg gataaatcat attacacctt caaaatacac   1647

 actctgaatt ataaagatgt gtttgttttc tttccaaatc atgtagaatt gatttccagt   1707

 tcaaggataa accaaaacaa tatttagaac tatcaagtga tctaatttat tttcttttgg   1767

 tttcttcttt acatttactg ttattttatt attattagta gtagcagcaa cagagtatga   1827

 tatgacccaa aagccattgt aaagtgccac attaccaaaa ttaattaagt aaactttata   1887

 gcctgtggga gtctattata tattattttg caaaagtagt aaatatatta ttgtttcatg   1947

 atgactcttg atgagatgct agaatgtaac catacattta tcttattttg aggatagaaa   2007

 tagcatggat ttcaacatca cttatttatc tgtataattg gaaataaaac accgatatga   2067

 tagagaatca ttccggcatt acctaacctc ttctgcagtt ggatctatgt attttcattg   2127

 gtctactgaa aacaaacaat acaattaaaa gcactaaaga ttattatatt aattcaactt   2187

 tgatctgata tatcacttaa actaaagggg tgtgtgtggt gtatgcttgt ttcctatttc   2247

 tgctctttaa agatactttg aatcaataaa accattagtc tacaaatcaa attgtgaact   2307

 taatctctag aaagagaata taactcagcc atttatagga atttaggttc aagtacagga   2367

 tatatgaaat cttttcccag tatttcagaa tgtacttaat tcacaggcag gatgcttcaa   2427

 tgcaaaatca tgaatatttt taattcaaaa ctaaaatgtc attaatatgt atgtatgcaa   2487

 atgttttatc ttattttctg aaatgcatct actttcatgg gctttgtacg tttctgagat   2547

 ttctcagtgt aataaaaaga gctcccaaac ttaaaaaaaa aaaa                    2591




      <210> 4
      <211> 2350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1346)

      <400> 4
 tgaagattca ttatgaggtg ctatacgtgg atgacctgct tagttttaat ttttggagaa     60

 atacatttta taaaacattt tcatcagatt gctaaaattg tgccacttga aga   atg     116
                                                              Met
                                                                1

 gat gat gat gat ttt ggt ggt ttt gag gct gcg gag act ttt gat ggt      164
 Asp Asp Asp Asp Phe Gly Gly Phe Glu Ala Ala Glu Thr Phe Asp Gly
               5                  10                  15

 gga agt ggt gaa acc caa aca aca tct cct gct att cct tgg gct gcc      212
 Gly Ser Gly Glu Thr Gln Thr Thr Ser Pro Ala Ile Pro Trp Ala Ala
          20                  25                  30

 ttt cct gca gta tct gga gtc cat ctt tca cca tct tct cct gag att      260
 Phe Pro Ala Val Ser Gly Val His Leu Ser Pro Ser Ser Pro Glu Ile
      35                  40                  45

 gta ctg gac cgt gac cac tct tct tcc att ggc tgc ctc tct tct gat      308
 Val Leu Asp Arg Asp His Ser Ser Ser Ile Gly Cys Leu Ser Ser Asp
  50                  55                  60                  65

 gcc att att tca tca cca gag aat aca cat gca gca aat agc att gtg      356
 Ala Ile Ile Ser Ser Pro Glu Asn Thr His Ala Ala Asn Ser Ile Val
                  70                  75                  80

 agt caa act att cca aaa gca cag att cag caa tca aca cac act cat      404
 Ser Gln Thr Ile Pro Lys Ala Gln Ile Gln Gln Ser Thr His Thr His
              85                  90                  95

 ctg gat atc tca ctt ttt cca ttg ggt tta act gat gaa aaa agt aat      452
 Leu Asp Ile Ser Leu Phe Pro Leu Gly Leu Thr Asp Glu Lys Ser Asn
         100                 105                 110

 gga aca att gcc ctt gtg gat gat tct gag gat cct gga gcc aat gta      500
 Gly Thr Ile Ala Leu Val Asp Asp Ser Glu Asp Pro Gly Ala Asn Val
     115                 120                 125

 tct aac ata cag ctt cag caa aaa att tca agt ctg gag att aaa ctc      548
 Ser Asn Ile Gln Leu Gln Gln Lys Ile Ser Ser Leu Glu Ile Lys Leu
 130                 135                 140                 145

 aaa gta tct gaa gaa gaa aaa cag aga att aaa cag gat gtg gaa tca      596
 Lys Val Ser Glu Glu Glu Lys Gln Arg Ile Lys Gln Asp Val Glu Ser
                 150                 155                 160

 ttg atg gaa aag cat aat gtc tta gaa aaa ggc ttt cta aaa gaa aaa      644
 Leu Met Glu Lys His Asn Val Leu Glu Lys Gly Phe Leu Lys Glu Lys
             165                 170                 175

 gag caa gag gcc att tct ttt caa gat aga tac aaa gaa ctt cag gaa      692
 Glu Gln Glu Ala Ile Ser Phe Gln Asp Arg Tyr Lys Glu Leu Gln Glu
         180                 185                 190

 aaa cat aaa caa gaa ttg gaa gac atg agg aaa gct ggt cac gaa gcc      740
 Lys His Lys Gln Glu Leu Glu Asp Met Arg Lys Ala Gly His Glu Ala
     195                 200                 205

 ctc agc att att gtg gat gaa tat aag gca cta ctg cag tct tca gtt      788
 Leu Ser Ile Ile Val Asp Glu Tyr Lys Ala Leu Leu Gln Ser Ser Val
 210                 215                 220                 225

 aag caa caa gta gaa gct att gaa aaa cag tac att tct gca att gag      836
 Lys Gln Gln Val Glu Ala Ile Glu Lys Gln Tyr Ile Ser Ala Ile Glu
                 230                 235                 240

 aaa cag gca cac aag tgt gag gag ttg cta aat gct cag gaa ata ttg      884
 Lys Gln Ala His Lys Cys Glu Glu Leu Leu Asn Ala Gln Glu Ile Leu
             245                 250                 255

 gaa aag tgt ttg gag gaa gaa agg caa aga aat aaa gag gca tta gta      932
 Glu Lys Cys Leu Glu Glu Glu Arg Gln Arg Asn Lys Glu Ala Leu Val
         260                 265                 270

 tcc gct gca aag ctt gaa aaa gaa gca gtg aag gat gca gtt tta aaa      980
 Ser Ala Ala Lys Leu Glu Lys Glu Ala Val Lys Asp Ala Val Leu Lys
     275                 280                 285

 gtc gta gaa gaa gaa aga aaa aat tta gaa aaa gcg cat gct gaa gaa     1028
 Val Val Glu Glu Glu Arg Lys Asn Leu Glu Lys Ala His Ala Glu Glu
 290                 295                 300                 305

 agg gaa tta tgg aag aca gaa cat gca aaa gat caa gaa aaa gta tct     1076
 Arg Glu Leu Trp Lys Thr Glu His Ala Lys Asp Gln Glu Lys Val Ser
                 310                 315                 320

 cag gaa att caa aaa gct ata caa gaa caa aga aaa ata agt cag gaa     1124
 Gln Glu Ile Gln Lys Ala Ile Gln Glu Gln Arg Lys Ile Ser Gln Glu
             325                 330                 335

 act gtt aag gca gca ata ata gaa gag cag aaa cga agt gaa aag gct     1172
 Thr Val Lys Ala Ala Ile Ile Glu Glu Gln Lys Arg Ser Glu Lys Ala
         340                 345                 350

 gtg gaa gag gca gtg aaa aga aca aga gat gaa ttg ata gag tat ata     1220
 Val Glu Glu Ala Val Lys Arg Thr Arg Asp Glu Leu Ile Glu Tyr Ile
     355                 360                 365

 aaa gaa cag aaa agg ctc gat caa gtc atc cgc caa aga agc ctg tcc     1268
 Lys Glu Gln Lys Arg Leu Asp Gln Val Ile Arg Gln Arg Ser Leu Ser
 370                 375                 380                 385

 agt ttg gaa ctg ttc ctc tcc tgt gca cag aaa cag tta agt gct tta     1316
 Ser Leu Glu Leu Phe Leu Ser Cys Ala Gln Lys Gln Leu Ser Ala Leu
                 390                 395                 400

 ata gct acg gaa cca gtt gac att gaa taa a aagaacatga caaacccaca     1367
 Ile Ala Thr Glu Pro Val Asp Ile Glu 
             405                 410

 ctggcattgg ataaatcata ttacaccttc aaaatacaca ctctgaatta taaagatgtg   1427

 tttgttttct ttccaaatca tgtagaattg atttccagtt caaggataaa ccaaaacaat   1487

 atttagaact atcaagtgat ctaatttatt ttcttttggt ttcttcttta catttactgt   1547

 tattttatta ttattagtag tagcagcaac agagtatgat atgacccaaa agccattgta   1607

 aagtgccaca ttaccaaaat taattaagta aactttatag cctgtgggag tctattatat   1667

 attattttgc aaaagtagta aatatattat tgtttcatga tgactcttga tgagatgcta   1727

 gaatgtaacc atacatttat cttattttga ggatagaaat agcatggatt tcaacatcac   1787

 ttatttatct gtataattgg aaataaaaca ccgatatgat agagaatcat tccggcatta   1847

 cctaacctct tctgcagttg gatctatgta ttttcattgg tctactgaaa acaaacaata   1907

 caattaaaag cactaaagat tattatatta attcaacttt gatctgatat atcacttaaa   1967

 ctaaaggggt gtgtgtggtg tatgcttgtt tcctatttct gctctttaaa gatactttga   2027

 atcaataaaa ccattagtct acaaatcaaa ttgtgaactt aatctctaga aagagaatat   2087

 aactcagcca tttataggaa tttaggttca agtacaggat atatgaaatc ttttcccagt   2147

 atttcagaat gtacttaatt cacaggcagg atgcttcaat gcaaaatcat gaatattttt   2207

 aattcaaaac taaaatgtca ttaatatgta tgtatgcaaa tgttttatct tattttctga   2267

 aatgcatcta ctttcatggg ctttgtacgt ttctgagatt tctcagtgta ataaaaagag   2327

 ctcccaaact taaaaaaaaa aaa                                           2350




      <210> 5
      <211> 2899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(2646)

      <400> 5
 cgaaaggtgt ttttggggaa aaaaatcaca atctggacgt gagaaaggac atgaggagac     60

 taaagacctg ggattttgtc aatcaga    atg aaa cca atg ttg aaa gac ttt     111
                                  Met Lys Pro Met Leu Lys Asp Phe
                                    1               5

 tca aat cta ttg ttg gtg gta ctc tgt gac tat gtt ctt gga gaa gct      159
 Ser Asn Leu Leu Leu Val Val Leu Cys Asp Tyr Val Leu Gly Glu Ala
      10                  15                  20

 gaa tat ctt ctc ttg aga gag cca ggc cat gta gca cta agc aac gac      207
 Glu Tyr Leu Leu Leu Arg Glu Pro Gly His Val Ala Leu Ser Asn Asp
  25                  30                  35                  40

 aca ggg tat gtg gat ttc cag tat ttt gat ggt gct aat ggg aca ctg      255
 Thr Gly Tyr Val Asp Phe Gln Tyr Phe Asp Gly Ala Asn Gly Thr Leu
                  45                  50                  55

 agg aat gta tct gtc ctg ctg ttg gag gcc aac acc aat cag act gta      303
 Arg Asn Val Ser Val Leu Leu Leu Glu Ala Asn Thr Asn Gln Thr Val
              60                  65                  70

 act acc aag tac ctc ctg acc aac cag tcc cag gga aca cta aag ttt      351
 Thr Thr Lys Tyr Leu Leu Thr Asn Gln Ser Gln Gly Thr Leu Lys Phe
          75                  80                  85

 gag tgc ttc tat ttc aag gag gct ggt gac tac tgg ttc aca atg act      399
 Glu Cys Phe Tyr Phe Lys Glu Ala Gly Asp Tyr Trp Phe Thr Met Thr
      90                  95                 100

 cca gaa gca aca gac aac agc act cca ttc ccc tgg tgg gag aaa agt      447
 Pro Glu Ala Thr Asp Asn Ser Thr Pro Phe Pro Trp Trp Glu Lys Ser
 105                 110                 115                 120

 gcc ttt ctg aag gtg gaa tgg cct gtc ttt cac gtt gac ttg aat agg      495
 Ala Phe Leu Lys Val Glu Trp Pro Val Phe His Val Asp Leu Asn Arg
                 125                 130                 135

 agt gcc aag gca gca gaa ggc acc ttc caa gtg ggc cta ttt acc agt      543
 Ser Ala Lys Ala Ala Glu Gly Thr Phe Gln Val Gly Leu Phe Thr Ser
             140                 145                 150

 caa cca ctg tgc ccg ttt cct gtg gac aag ccc aac att gta gtg gat      591
 Gln Pro Leu Cys Pro Phe Pro Val Asp Lys Pro Asn Ile Val Val Asp
         155                 160                 165

 gtc atc ttc acc aac agt ctt cct gag gca aga aga aat tca aga cag      639
 Val Ile Phe Thr Asn Ser Leu Pro Glu Ala Arg Arg Asn Ser Arg Gln
     170                 175                 180

 ccg ctg gaa ata aga acc agc aaa agg aca gaa ctt gct caa ggt cag      687
 Pro Leu Glu Ile Arg Thr Ser Lys Arg Thr Glu Leu Ala Gln Gly Gln
 185                 190                 195                 200

 tgg gtt gag ttt ggc tgt gca ccc ttg ggg cca gaa gcc tat gtc acc      735
 Trp Val Glu Phe Gly Cys Ala Pro Leu Gly Pro Glu Ala Tyr Val Thr
                 205                 210                 215

 gtg gtg ctg aag ctg ctt ggg cga gac tca gtc att acc tcc aca gga      783
 Val Val Leu Lys Leu Leu Gly Arg Asp Ser Val Ile Thr Ser Thr Gly
             220                 225                 230

 ccc att gac ctg gcc cag aaa ttt gga tac aaa ctg gtg atg gtg cca      831
 Pro Ile Asp Leu Ala Gln Lys Phe Gly Tyr Lys Leu Val Met Val Pro
         235                 240                 245

 gaa ctc aca tgt gag tcc ggg gta gag gtg aca gtg ctg cct cca cca      879
 Glu Leu Thr Cys Glu Ser Gly Val Glu Val Thr Val Leu Pro Pro Pro
     250                 255                 260

 tgc acc ttc gtc caa gga gtg gtc act gtc ttc aag gag gcc ccc aga      927
 Cys Thr Phe Val Gln Gly Val Val Thr Val Phe Lys Glu Ala Pro Arg
 265                 270                 275                 280

 tac cct ggg aag agg acc att cac ttg gct aaa aac agc ctg ccc ctg      975
 Tyr Pro Gly Lys Arg Thr Ile His Leu Ala Lys Asn Ser Leu Pro Leu
                 285                 290                 295

 gga gag agg agg aca att ttt aac tgt act ttg ttt gac atg ggg aag     1023
 Gly Glu Arg Arg Thr Ile Phe Asn Cys Thr Leu Phe Asp Met Gly Lys
             300                 305                 310

 aat aag tac tgc ttt gac ttt ggc att tca agc aga agc cat ttt tct     1071
 Asn Lys Tyr Cys Phe Asp Phe Gly Ile Ser Ser Arg Ser His Phe Ser
         315                 320                 325

 gca aag gag gag tgc atg cta att cag aga aat aca gaa act tgg gga     1119
 Ala Lys Glu Glu Cys Met Leu Ile Gln Arg Asn Thr Glu Thr Trp Gly
     330                 335                 340

 ctg tgg cag cca tgg agc cag tgt agt gcc aca tgt ggg gat ggt gtc     1167
 Leu Trp Gln Pro Trp Ser Gln Cys Ser Ala Thr Cys Gly Asp Gly Val
 345                 350                 355                 360

 aga gag cgt cgc cga gtg tgt ctc act tcc ttc ccc tcc agt cct gtc     1215
 Arg Glu Arg Arg Arg Val Cys Leu Thr Ser Phe Pro Ser Ser Pro Val
                 365                 370                 375

 tgc cct gga atg tcc ttg gag gcc tcc ctg tgt tcc ctg gag gag tgt     1263
 Cys Pro Gly Met Ser Leu Glu Ala Ser Leu Cys Ser Leu Glu Glu Cys
             380                 385                 390

 gct gct ttc cag cca tcc agc cca tct cct ctt cag ccc cag ggt cca     1311
 Ala Ala Phe Gln Pro Ser Ser Pro Ser Pro Leu Gln Pro Gln Gly Pro
         395                 400                 405

 gtg aag tcc aac aac atc gtg act gtc act ggt ata tcc ttg tgc ttg     1359
 Val Lys Ser Asn Asn Ile Val Thr Val Thr Gly Ile Ser Leu Cys Leu
     410                 415                 420

 ttc atc atc att gcc act gtg ctc atc acg ctg tgg agg agg ttc ggc     1407
 Phe Ile Ile Ile Ala Thr Val Leu Ile Thr Leu Trp Arg Arg Phe Gly
 425                 430                 435                 440

 cgg cca gcc aag tgc agc aca cct gct cga cac aac tcc atc cac tcc     1455
 Arg Pro Ala Lys Cys Ser Thr Pro Ala Arg His Asn Ser Ile His Ser
                 445                 450                 455

 ccc agc ttc cgg aag aac tcg gac gag gag aat atc tgc gag ctg agc     1503
 Pro Ser Phe Arg Lys Asn Ser Asp Glu Glu Asn Ile Cys Glu Leu Ser
             460                 465                 470

 gag cag cgc ggg agc ttc tcg gat ggg gga gac ggg ccc acg ggg agt     1551
 Glu Gln Arg Gly Ser Phe Ser Asp Gly Gly Asp Gly Pro Thr Gly Ser
         475                 480                 485

 cca ggg gac aca ggc atc cct ctg acc tac agg cgg agc ggg ccg gta     1599
 Pro Gly Asp Thr Gly Ile Pro Leu Thr Tyr Arg Arg Ser Gly Pro Val
     490                 495                 500

 cct ccc gag gat gat gcc tct ggc agc gag agc ttc cag tcc aac gcc     1647
 Pro Pro Glu Asp Asp Ala Ser Gly Ser Glu Ser Phe Gln Ser Asn Ala
 505                 510                 515                 520

 cag aag ata atc cca cct ctg ttc agc tac cgc ctt gcc cag cag cag     1695
 Gln Lys Ile Ile Pro Pro Leu Phe Ser Tyr Arg Leu Ala Gln Gln Gln
                 525                 530                 535

 tta aag gag atg aaa aag aaa ggt ctg acg gaa act acc aaa gtg tat     1743
 Leu Lys Glu Met Lys Lys Lys Gly Leu Thr Glu Thr Thr Lys Val Tyr
             540                 545                 550

 cac gtg tct cag agt ccc ctg aca gac act gcc att gat gcg gcc ccc     1791
 His Val Ser Gln Ser Pro Leu Thr Asp Thr Ala Ile Asp Ala Ala Pro
         555                 560                 565

 agc gct ccc tta gat ttg gaa agc ccg gaa gaa gct gca gca aac aag     1839
 Ser Ala Pro Leu Asp Leu Glu Ser Pro Glu Glu Ala Ala Ala Asn Lys
     570                 575                 580

 ttc cgg atc aaa tcc cca ttt ccg gag cag ccc gcg gtc agt gcc ggg     1887
 Phe Arg Ile Lys Ser Pro Phe Pro Glu Gln Pro Ala Val Ser Ala Gly
 585                 590                 595                 600

 gaa agg cct ccc tcc agg ctg gat cta aat gtg act cag gcc agt tgt     1935
 Glu Arg Pro Pro Ser Arg Leu Asp Leu Asn Val Thr Gln Ala Ser Cys
                 605                 610                 615

 gcc ata agc ccc agc cag act ctg atc cgc aag tca cag gca agg cac     1983
 Ala Ile Ser Pro Ser Gln Thr Leu Ile Arg Lys Ser Gln Ala Arg His
             620                 625                 630

 gtg ggc agc aga ggg ggc ccg tcc gaa agg agc cat gcc agg aac gcc     2031
 Val Gly Ser Arg Gly Gly Pro Ser Glu Arg Ser His Ala Arg Asn Ala
         635                 640                 645

 cat ttc agg agg aca gcg agt ttc cat gaa gcc agg cag gcc cgg ccg     2079
 His Phe Arg Arg Thr Ala Ser Phe His Glu Ala Arg Gln Ala Arg Pro
     650                 655                 660

 ttc cga gag agg agc atg tcc act ctg act cca cgg cag gcc cct gcc     2127
 Phe Arg Glu Arg Ser Met Ser Thr Leu Thr Pro Arg Gln Ala Pro Ala
 665                 670                 675                 680

 tac agc tct agg acg cgg acc tgc gag cag gca gag gac aga ttt agg     2175
 Tyr Ser Ser Arg Thr Arg Thr Cys Glu Gln Ala Glu Asp Arg Phe Arg
                 685                 690                 695

 cct cag agt cga ggt gcc cac ctg ttt cct gaa aaa ctg gag cat ttc     2223
 Pro Gln Ser Arg Gly Ala His Leu Phe Pro Glu Lys Leu Glu His Phe
             700                 705                 710

 caa gag gca agt gga acc cgt ggt cca tta aac cct ctc cct aaa tcc     2271
 Gln Glu Ala Ser Gly Thr Arg Gly Pro Leu Asn Pro Leu Pro Lys Ser
         715                 720                 725

 tac act ttg ggg cag ccc ttg agg aaa cca gac ctt ggg gat cac cag     2319
 Tyr Thr Leu Gly Gln Pro Leu Arg Lys Pro Asp Leu Gly Asp His Gln
     730                 735                 740

 gca gga tta gtg gcc gga att gag aga aca gag ccc cac aga gct cgt     2367
 Ala Gly Leu Val Ala Gly Ile Glu Arg Thr Glu Pro His Arg Ala Arg
 745                 750                 755                 760

 cgg gga ccg tcc ccc agt cac aag agt gtc tca agg aag cag tct tct     2415
 Arg Gly Pro Ser Pro Ser His Lys Ser Val Ser Arg Lys Gln Ser Ser
                 765                 770                 775

 ccc ata tcc ccc aaa gat aac tac cag agg gtc agt tct ctg agc cct     2463
 Pro Ile Ser Pro Lys Asp Asn Tyr Gln Arg Val Ser Ser Leu Ser Pro
             780                 785                 790

 tct cag tgt aga aaa gac aag tgt caa agc ttc ccc act cac cct gag     2511
 Ser Gln Cys Arg Lys Asp Lys Cys Gln Ser Phe Pro Thr His Pro Glu
         795                 800                 805

 ttt gcc ttc tat gac aat acg tcg ttt ggc ctc act gag gct gag cag     2559
 Phe Ala Phe Tyr Asp Asn Thr Ser Phe Gly Leu Thr Glu Ala Glu Gln
     810                 815                 820

 agg atg ctg gac ctc cca gga tat ttt ggg tca aat gaa gag gat gaa     2607
 Arg Met Leu Asp Leu Pro Gly Tyr Phe Gly Ser Asn Glu Glu Asp Glu
 825                 830                 835                 840

 acc aca agt aca ctt agc gtg gag aag ctg gtg atc tag actgagaatc      2656
 Thr Thr Ser Thr Leu Ser Val Glu Lys Leu Val Ile 
                 845                 850

 agcctgagct ttacacagct ggggtctgct actcgcgttt tgtagacttt tgtgtaacta   2716

 tttgtaccgt aggacagaat gtgaggagga agtaacacac agaggaggat gtgtgtgtat   2776

 gcatgtgttt gaattcacaa ggaagaaatt atttatcttg agctttttcc tttgttattc   2836

 aatttctatt gatttattag taataacaat gataataaaa tgtaaatgag caaaaaaaaa   2896

 aaa                                                                 2899




      <210> 6
      <211> 938
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(851)

      <400> 6
 agggctccgt ggacatctca ggtcttcagg gtcttccatc tggaactata taaagttcag     60

 aaaac    atg tct cga aga tat gac tcc agg acc act ata ttt tct cca     107
          Met Ser Arg Arg Tyr Asp Ser Arg Thr Thr Ile Phe Ser Pro
            1               5                  10

 gaa ggt cgc tta tac caa gtt gaa tat gcc atg gaa gct att gga cat      155
 Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Met Glu Ala Ile Gly His
  15                  20                  25                  30

 gca ggc acc tgt ttg gga att tta gca aat gat ggt gtt ttg ctt gca      203
 Ala Gly Thr Cys Leu Gly Ile Leu Ala Asn Asp Gly Val Leu Leu Ala
                  35                  40                  45

 gca gag aga cgc aac atc cac aag ctt ctt gat gaa gtc ttt ttt tct      251
 Ala Glu Arg Arg Asn Ile His Lys Leu Leu Asp Glu Val Phe Phe Ser
              50                  55                  60

 gaa aaa att tat aaa ctc aat gag gac atg gct tgc agt gtg gca ggc      299
 Glu Lys Ile Tyr Lys Leu Asn Glu Asp Met Ala Cys Ser Val Ala Gly
          65                  70                  75

 ata act tct gat gct aat gtt ctg act aat gaa cta agg ctc att gct      347
 Ile Thr Ser Asp Ala Asn Val Leu Thr Asn Glu Leu Arg Leu Ile Ala
      80                  85                  90

 caa agg tat tta tta cag tat cag gag cca ata cct tgt gag cag ttg      395
 Gln Arg Tyr Leu Leu Gln Tyr Gln Glu Pro Ile Pro Cys Glu Gln Leu
  95                 100                 105                 110

 gtt aca gcg ctg tgt gat atc aaa caa gct tat aca caa ttt gga gga      443
 Val Thr Ala Leu Cys Asp Ile Lys Gln Ala Tyr Thr Gln Phe Gly Gly
                 115                 120                 125

 aaa cgt ccc ttt ggt gtt tca ttg ctg tac att ggc tgg gat aag cac      491
 Lys Arg Pro Phe Gly Val Ser Leu Leu Tyr Ile Gly Trp Asp Lys His
             130                 135                 140

 tat ggc ttt cag ctc tat cag agt gac cct agt gga aat tac ggg gga      539
 Tyr Gly Phe Gln Leu Tyr Gln Ser Asp Pro Ser Gly Asn Tyr Gly Gly
         145                 150                 155

 tgg aag gcc aca tgc att gga aat aat agc gct gca gct gtg tca atg      587
 Trp Lys Ala Thr Cys Ile Gly Asn Asn Ser Ala Ala Ala Val Ser Met
     160                 165                 170

 ttg aaa caa gac tat aaa gaa gga gaa atg acc ttg aag tca gca ctt      635
 Leu Lys Gln Asp Tyr Lys Glu Gly Glu Met Thr Leu Lys Ser Ala Leu
 175                 180                 185                 190

 gct tta gct atc aaa gta cta aat aag acc atg gat gtt agt aaa ctc      683
 Ala Leu Ala Ile Lys Val Leu Asn Lys Thr Met Asp Val Ser Lys Leu
                 195                 200                 205

 tct gct gaa aaa gtg gaa att gca aca cta aca aga gag aat gga aag      731
 Ser Ala Glu Lys Val Glu Ile Ala Thr Leu Thr Arg Glu Asn Gly Lys
             210                 215                 220

 aca gta atc aga gtt ctc aaa caa aaa gaa gtg gag cag ttg atc aaa      779
 Thr Val Ile Arg Val Leu Lys Gln Lys Glu Val Glu Gln Leu Ile Lys
         225                 230                 235

 aaa cac gag gaa gaa gaa gcc aaa gct gag cgt gag aag aaa gaa aaa      827
 Lys His Glu Glu Glu Glu Ala Lys Ala Glu Arg Glu Lys Lys Glu Lys
     240                 245                 250

 gaa cag aaa gaa aag gat aaa tag aatcagagat tttattactc atttggggca     881
 Glu Gln Lys Glu Lys Asp Lys 
 255                 260

 ccatttcagt gtaaaagcag tcctactctt ccacactagg aaggctttac ttttttt       938




      <210> 7
      <211> 1015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(753)

      <400> 7
 tccgtggaca tctcaggtct tcagggtctt ccatctggaa ctatataaag ttcagaaaac     60
                                                                 
 atg tct cga aga tat gac tcc agg acc act ata ttt tct cca gaa gca      108
 Met Ser Arg Arg Tyr Asp Ser Arg Thr Thr Ile Phe Ser Pro Glu Ala
   1               5                  10                  15

 gag aga cgc aac atc cac aag ctt ctt gat gaa gtc ttt ttt tct gaa      156
 Glu Arg Arg Asn Ile His Lys Leu Leu Asp Glu Val Phe Phe Ser Glu
              20                  25                  30

 aaa att tat aaa ctc aat gag gac atg gct tgc agt gtg gca ggc ata      204
 Lys Ile Tyr Lys Leu Asn Glu Asp Met Ala Cys Ser Val Ala Gly Ile
          35                  40                  45

 act tct gat gct aat gtt ctg act aat gaa cta agg ctc att gct caa      252
 Thr Ser Asp Ala Asn Val Leu Thr Asn Glu Leu Arg Leu Ile Ala Gln
      50                  55                  60

 agg tat tta tta cag tat cag gag cca ata cct tgt gag cag ttg gtt      300
 Arg Tyr Leu Leu Gln Tyr Gln Glu Pro Ile Pro Cys Glu Gln Leu Val
  65                  70                  75                  80

 aca gcg ctg tgt gat atc aaa caa gct tat aca caa ttt gga gga aaa      348
 Thr Ala Leu Cys Asp Ile Lys Gln Ala Tyr Thr Gln Phe Gly Gly Lys
                  85                  90                  95

 cgt ccc ttt ggt gtt tca ttg ctg tac att ggc tgg gat aag cac tat      396
 Arg Pro Phe Gly Val Ser Leu Leu Tyr Ile Gly Trp Asp Lys His Tyr
             100                 105                 110

 ggc ttt cag ctc tat cag agt gac cct agt gga aat tac ggg gga tgg      444
 Gly Phe Gln Leu Tyr Gln Ser Asp Pro Ser Gly Asn Tyr Gly Gly Trp
         115                 120                 125

 aag gcc aca tgc att gga aat aat agc gct gca gct gtg tca atg ttg      492
 Lys Ala Thr Cys Ile Gly Asn Asn Ser Ala Ala Ala Val Ser Met Leu
     130                 135                 140

 aaa caa gac tat aaa gaa gga gaa atg acc ttg aag tca gca ctt gct      540
 Lys Gln Asp Tyr Lys Glu Gly Glu Met Thr Leu Lys Ser Ala Leu Ala
 145                 150                 155                 160

 tta gct atc aaa gta cta aat aag acc atg gat gtt agt aaa ctc tct      588
 Leu Ala Ile Lys Val Leu Asn Lys Thr Met Asp Val Ser Lys Leu Ser
                 165                 170                 175

 gct gaa aaa gtg gaa att gca aca cta aca aga gag aat gga aag aca      636
 Ala Glu Lys Val Glu Ile Ala Thr Leu Thr Arg Glu Asn Gly Lys Thr
             180                 185                 190

 gta atc aga gtt ctc aaa caa aaa gaa gtg gag cag ttg atc aaa aaa      684
 Val Ile Arg Val Leu Lys Gln Lys Glu Val Glu Gln Leu Ile Lys Lys
         195                 200                 205

 cat gag gaa gaa gaa gcc aaa gct gag cgt gag aag aaa gaa aaa gaa      732
 His Glu Glu Glu Glu Ala Lys Ala Glu Arg Glu Lys Lys Glu Lys Glu
     210                 215                 220

 cag aaa gaa aag gat aaa tag aa tcagagattt tattactcat ttggggcacc      785
 Gln Lys Glu Lys Asp Lys 
 225                 230

 atttcagtgt aaaagcagtc ctactcttcc acactaggaa ggctttactt tttttaactg    845

 gtgcagtggg aaaataggac attacatact gaattgggtc cttgtcattt ctgtccaatt    905

 gaatacttta ttgtaacgat gatggttacc cttcatggac gtcttaatct tccacacaca    965

 tccccttttt ttggaataaa atttggaaaa tggaaatgaa aaaaaaaaaa              1015




      <210> 8
      <211> 1929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(1141)

      <400> 8
 g    atg gag ttc gac tgc gag ggc ctg aga cgg ctg ctt ggc aag tac      46
      Met Glu Phe Asp Cys Glu Gly Leu Arg Arg Leu Leu Gly Lys Tyr
        1               5                  10                  15

 aag ttc agg gac cta act gtg gaa gaa cta agg aat gta aat gta ttt       94
 Lys Phe Arg Asp Leu Thr Val Glu Glu Leu Arg Asn Val Asn Val Phe
                  20                  25                  30

 ttc cca cat ttc aaa tat tcc atg gac acc tat gtt ttt aaa gat agt      142
 Phe Pro His Phe Lys Tyr Ser Met Asp Thr Tyr Val Phe Lys Asp Ser
              35                  40                  45

 tct cag aaa gac ctg ctg aat ttt act ggc aca att cct gtg atg tat      190
 Ser Gln Lys Asp Leu Leu Asn Phe Thr Gly Thr Ile Pro Val Met Tyr
          50                  55                  60

 cag ggt aat aca tat aac ata cca att cgt ttc tgg att ttg gat tct      238
 Gln Gly Asn Thr Tyr Asn Ile Pro Ile Arg Phe Trp Ile Leu Asp Ser
      65                  70                  75

 cac cct ttc gct ccc cct att tgc ttc ttg aag cca act gca aat atg      286
 His Pro Phe Ala Pro Pro Ile Cys Phe Leu Lys Pro Thr Ala Asn Met
  80                  85                  90                  95

 gga atc tta gtc gga aaa cat gtg gat gct caa ggc aga ata tat ttg      334
 Gly Ile Leu Val Gly Lys His Val Asp Ala Gln Gly Arg Ile Tyr Leu
                 100                 105                 110

 ccc tat ctc caa aac tgg agc cat cct aaa tct gtc att gtt gga tta      382
 Pro Tyr Leu Gln Asn Trp Ser His Pro Lys Ser Val Ile Val Gly Leu
             115                 120                 125

 att aaa gaa atg att gcc aag ttt caa gag gaa ctt ccc atg tat tct      430
 Ile Lys Glu Met Ile Ala Lys Phe Gln Glu Glu Leu Pro Met Tyr Ser
         130                 135                 140

 cta tca tca tct gat gag gca cgg cag gta gac ttg cta gcc tat att      478
 Leu Ser Ser Ser Asp Glu Ala Arg Gln Val Asp Leu Leu Ala Tyr Ile
     145                 150                 155

 gca aaa atc act gaa ggt gtt tca gat aca aat tca aag agc tgg gca      526
 Ala Lys Ile Thr Glu Gly Val Ser Asp Thr Asn Ser Lys Ser Trp Ala
 160                 165                 170                 175

 aat cat gag aat aaa aca gtc aat aaa att act gtg gtt gga ggt gga      574
 Asn His Glu Asn Lys Thr Val Asn Lys Ile Thr Val Val Gly Gly Gly
                 180                 185                 190

 gaa ctc ggt att gcc tgc aca tta gca att tca gca aag ggt att gca      622
 Glu Leu Gly Ile Ala Cys Thr Leu Ala Ile Ser Ala Lys Gly Ile Ala
             195                 200                 205

 gac agg ctt gtc ctc tta gac ctc tca gaa ggg act aaa gga gcc acg      670
 Asp Arg Leu Val Leu Leu Asp Leu Ser Glu Gly Thr Lys Gly Ala Thr
         210                 215                 220

 atg gac ctt gaa atc ttc aac ctt cct aat gtg gag atc agc aaa gat      718
 Met Asp Leu Glu Ile Phe Asn Leu Pro Asn Val Glu Ile Ser Lys Asp
     225                 230                 235

 ttg tct gcc tct gct cat tcc aag gtg gtg atc ttc aca gtc aac tct      766
 Leu Ser Ala Ser Ala His Ser Lys Val Val Ile Phe Thr Val Asn Ser
 240                 245                 250                 255

 ttg ggt agt tct cag tcg tac ctt gat gtg gta cag agc aat gtg gat      814
 Leu Gly Ser Ser Gln Ser Tyr Leu Asp Val Val Gln Ser Asn Val Asp
                 260                 265                 270

 atg ttc aga gcc ctt gtc cca gct ctg gga cat tat agt caa cac agt      862
 Met Phe Arg Ala Leu Val Pro Ala Leu Gly His Tyr Ser Gln His Ser
             275                 280                 285

 gtc ctg ctc gtt gca tct caa cca gtg gaa atc atg acc tat gta aca      910
 Val Leu Leu Val Ala Ser Gln Pro Val Glu Ile Met Thr Tyr Val Thr
         290                 295                 300

 tgg aaa ctg agt aca ttt cct gca aat cga gtg atc gga att gga tgt      958
 Trp Lys Leu Ser Thr Phe Pro Ala Asn Arg Val Ile Gly Ile Gly Cys
     305                 310                 315

 aat ctg gat tca cag aga tta cag tat att att aca aat gtt ttg aag     1006
 Asn Leu Asp Ser Gln Arg Leu Gln Tyr Ile Ile Thr Asn Val Leu Lys
 320                 325                 330                 335

 gca cag act tca ggc aaa gaa gta tgg gtt att ggc gag caa gga gaa     1054
 Ala Gln Thr Ser Gly Lys Glu Val Trp Val Ile Gly Glu Gln Gly Glu
                 340                 345                 350

 gac aaa gtg ctc aca tgg agt ggc caa gaa gaa gta gtg agt ctt acc     1102
 Asp Lys Val Leu Thr Trp Ser Gly Gln Glu Glu Val Val Ser Leu Thr
             355                 360                 365

 tct caa gtg cag ctg tcc aac agg gat att atg ata taa atagtgaagt      1151
 Ser Gln Val Gln Leu Ser Asn Arg Asp Ile Met Ile 
         370                 375

 gtttttaagt ttgccttgca tccttggaac caatggagta tctgaagtta tcaaaaccac   1211

 actgaaagaa gatacagtta ctgagaaact ccaaagcagt gcatcctcaa tccacagtct   1271

 ccaacaacag ttaaaacttt gattctcaaa tgcaatttga gaggctggac ttctacctaa   1331

 agggaaaagt catttaattt tacctatata taggtttgag gatttctgta tcctgctact   1391

 tacttttaca aactgcttgg ttaaagtaga gggtttcttg attagctttg tgatgtaaat   1451

 ccttaaggag ttatacaagg aggggaaaaa ttaattttat ttggggttct tgagatatct   1511

 atgctgttct ttaaatctac agcaggggta aacattcatc tgcagtgtgc atcaatttaa   1571

 atcatatatc ctaaactaaa agcacaattc atacttcggg aatattttat aagtaatata   1631

 tctttaaaag aaaattaccc tttgactttt ataatcaaca taagttccag gcccagtatg   1691

 gatttacaaa atctgtgtca gttgtacatt cacaggatcc acagcttaag ttactaatgt   1751

 ttcttgtgta aaatcctgtt ggtagtaata gtaaagcatt gtatttccct tcttcaaatt   1811

 aattacctac caaaaaatgg aaaagaattt tacatgcact ttaaaatagt aaaatggaaa   1871

 gtgaattttt aaaatatatg cattaaaagt ttactttaat ttccaaaaaa aaaaaaaa     1929




      <210> 9
      <211> 2288
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(721)

      <400> 9
 tcgtctctcc ctggaaaggg agggaggctt cgacgtcgag agggagccgc tgccgcgtta     60

 gttccgagct gaagtcacta ggacttctct caaacttgtg tgctgaggag actcagatgt    120

 tggcctcagc tcctaggctg aactcagcag atcggcccat gaaaacttct gtattgagac    180

 aaaggaaggg atctgtcaga aagcaacact tgttatcttg ggcttggcag caaggaagag    240

 gacaggtagt ggagatcctg caatctgaaa agcagactga aaggtgacaa agaagctgaa    300

 g    atg ggt ggt gga gag agg tat aac att cca gcc cct caa tct aga     346
      Met Gly Gly Gly Glu Arg Tyr Asn Ile Pro Ala Pro Gln Ser Arg
        1               5                  10                  15

 aat gtt agt aag aac caa caa cag ctt aac aga cag aag acc aag gaa      394
 Asn Val Ser Lys Asn Gln Gln Gln Leu Asn Arg Gln Lys Thr Lys Glu
                  20                  25                  30

 cag aat tcc cag atg aag att gtt cat aag aaa aaa gaa aga gga cat      442
 Gln Asn Ser Gln Met Lys Ile Val His Lys Lys Lys Glu Arg Gly His
              35                  40                  45

 ggt tat aac tca tca gca gct gcc tgg cag gcc atg caa aat ggg ggg      490
 Gly Tyr Asn Ser Ser Ala Ala Ala Trp Gln Ala Met Gln Asn Gly Gly
          50                  55                  60

 aag aac aaa aat ttt cca aat aat caa agt tgg aat tct agc tta tca      538
 Lys Asn Lys Asn Phe Pro Asn Asn Gln Ser Trp Asn Ser Ser Leu Ser
      65                  70                  75

 ggt ccc agg tta ctt ttt aaa tct caa gct aat cag aac tat gct ggt      586
 Gly Pro Arg Leu Leu Phe Lys Ser Gln Ala Asn Gln Asn Tyr Ala Gly
  80                  85                  90                  95

 gcc aaa ttt agt gag ccg cca tca cca agt gtt ctt ccc aaa cca cca      634
 Ala Lys Phe Ser Glu Pro Pro Ser Pro Ser Val Leu Pro Lys Pro Pro
                 100                 105                 110

 agc cac tgg gtc cct gtt tcc ttt aat cct tca gat aag gaa ata atg      682
 Ser His Trp Val Pro Val Ser Phe Asn Pro Ser Asp Lys Glu Ile Met
             115                 120                 125

 aca ttt caa ctt aaa acc tta ctt aaa gta cag gta taa aataagacaa       731
 Thr Phe Gln Leu Lys Thr Leu Leu Lys Val Gln Val 
         130                 135

 atgtttaaat ttagttatgt tcacgggtag ttgtcaattg gtctgaaaca aatttgctag    791

 ggaatctatt tgtgtagaac taattaatgt aaaaaaaata gaccatctcg tgttgtgtgc    851

 actgtgatat aatggtagta tcagtgcaac ttaaactaat gattgtactt gatattaagt    911

 gttctcaact gagtaacttt taagtggaaa ccaagtttag atttggggag tggtaaagga    971

 atcagctttt tctattgtta ggggaagaca gtaatttatc attcatggac cagtagattg   1031

 ttgaaagttg gtgaatcgga ttataagctt ctagctaaca caaggattca gaattaggta   1091

 aacatctgaa ggtttagtat attagaaaca cccaaaccag taatatgcta acctgatgca   1151

 ctgctgaaag aaaatgtgaa tttttcgtaa taattgcatt ttagtgaatt gtacagtggg   1211

 tggaaagggc atttggagct cattagaatg agacatagta caccccaatg gccctgttta   1271

 ttaaatgtag tggattaagt gtctgtcaac aaatacacca aaaccatttt ttatagaaac   1331

 agtatttaat ggtcactcaa tagctttcaa aatacatttt tgtattacag cactgcacaa   1391

 gctattctaa tagtgctctg gcctcatcat tcctgcaaag cttgctttgg ggagttggat   1451

 aatgtgaaaa ttttaagtac ctaggggaga aagagccatg taaatatctg taataaactt   1511

 gtagcatatg taaagttttc ttggccttta tcttacaaaa atggagtatt ttagtatgaa   1571

 tttgctgaat gtaagaccgt ggactgtttt ttataatatg gcctaatttt aaaggtccaa   1631

 aataacttgt ttttaaagtt tgcccttgtg ctaaagtgcc agtgtatgta tgttatactt   1691

 gatttggttg taaactatat ttcaaagtaa accctagtgt aataagtttt ataactaaaa   1751

 aggtttaagc tgctaaaact atttttaaga gatgtgaaat gcagtatggg actatctttt   1811

 tttcctcctc taagcccaaa gattaactag agtccctcca accttataga ttgttggctt   1871

 tcacaatctt ataacctagg atacaggtag tttcgagtat ggtgccagtg atgttttgtt   1931

 tttgtttggt caaggggtag gtgcaaccca atggaccact tatgcaaaag atgtaaactc   1991

 ttgcataata cattgataac atgttttgcc aactttaaat gcttaaacat aagcgaaacc   2051

 agtagcaagt atgtgggtca gcttaaaaat tttgattgtt aatgccctat tttctaattt   2111

 ggcacctctt gatgcctaag caggtaagca gatgcctaag ctgtatttct ccaaataaat   2171

 caagatgaag tactgcccaa gttaaatatt gatagcctaa agacaagttt atgtagtact   2231

 taatgtacat gatatgaagc ataaaattaa ataaaatttt tccccaaaaa aaaaaaa      2288




      <210> 10
      <211> 2742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(1597)

      <400> 10
 tggctcttag catgtggttg ggacaagctt tctgtgcctg gctaagtttt atgaacagat     60

 ggcacagcaa attcctgatg gttaggtcaa gaggaga atg tgg tgc cca ccg cca     115
                                          Met Trp Cys Pro Pro Pro
                                            1               5

 act tct gtg tgt gtt tgt ttt cag aga ctc cct acg gga ggg gat gcc      163
 Thr Ser Val Cys Val Cys Phe Gln Arg Leu Pro Thr Gly Gly Asp Ala
              10                  15                  20

 ccg cag gaa cat gga gcg gca ttg ccc ccg aat gtc cag att atc cct      211
 Pro Gln Glu His Gly Ala Ala Leu Pro Pro Asn Val Gln Ile Ile Pro
          25                  30                  35

 gtt ttt gtg acc aaa gag gaa gcc att agt ctc cac gag ttc ccg gtg      259
 Val Phe Val Thr Lys Glu Glu Ala Ile Ser Leu His Glu Phe Pro Val
      40                  45                  50

 gaa cag atg aca agg tct cta gca tct cca gca gga ctc cag gat ggt      307
 Glu Gln Met Thr Arg Ser Leu Ala Ser Pro Ala Gly Leu Gln Asp Gly
  55                  60                  65                  70

 tca gcc cag cac cat cca aag ggt ggg agc aca tct gcc ctg aaa gaa      355
 Ser Ala Gln His His Pro Lys Gly Gly Ser Thr Ser Ala Leu Lys Glu
                  75                  80                  85

 aac gcc act ggc cat gtg gaa tcc atg gcc tgg acc acc cca gat ccc      403
 Asn Ala Thr Gly His Val Glu Ser Met Ala Trp Thr Thr Pro Asp Pro
              90                  95                 100

 aca tcc cct gac gaa gct tgt cca gat ggc agg aag gag aac gga tgc      451
 Thr Ser Pro Asp Glu Ala Cys Pro Asp Gly Arg Lys Glu Asn Gly Cys
         105                 110                 115

 ttg tct ggc cat gat ctg gag agc atc agg ccc gca gga ctg cac aac      499
 Leu Ser Gly His Asp Leu Glu Ser Ile Arg Pro Ala Gly Leu His Asn
     120                 125                 130

 tct gcc agg ggt gag gtt ctt ggc ctc agc tcc tcc ctg ggg aag gaa      547
 Ser Ala Arg Gly Glu Val Leu Gly Leu Ser Ser Ser Leu Gly Lys Glu
 135                 140                 145                 150

 cta gtc ttt ctc caa gaa gaa ctc gac ttg tct gaa atc cac att cca      595
 Leu Val Phe Leu Gln Glu Glu Leu Asp Leu Ser Glu Ile His Ile Pro
                 155                 160                 165

 gag gct cag gaa gtg gaa atg gcc tca ggt cat ttt gcc ttc cta cat      643
 Glu Ala Gln Glu Val Glu Met Ala Ser Gly His Phe Ala Phe Leu His
             170                 175                 180

 gtg cct gtt cca gat ggc agg gct cct tac tgc aag gca tct ctc agc      691
 Val Pro Val Pro Asp Gly Arg Ala Pro Tyr Cys Lys Ala Ser Leu Ser
         185                 190                 195

 gcc tcc agc agc ctg gaa ccc acg cct cct gag gac aca gcc atc agc      739
 Ala Ser Ser Ser Leu Glu Pro Thr Pro Pro Glu Asp Thr Ala Ile Ser
     200                 205                 210

 agc ttg cgc cct ccc tct gct cct gag atg ctg acc cag cat gga gcc      787
 Ser Leu Arg Pro Pro Ser Ala Pro Glu Met Leu Thr Gln His Gly Ala
 215                 220                 225                 230

 caa gag cag ctc gaa gac cat cct ggc cat agc agc caa gcc ccc att      835
 Gln Glu Gln Leu Glu Asp His Pro Gly His Ser Ser Gln Ala Pro Ile
                 235                 240                 245

 ccc aga gca gac cct ctc ccc aga agg acc cgc agg ccc ttg tta ttg      883
 Pro Arg Ala Asp Pro Leu Pro Arg Arg Thr Arg Arg Pro Leu Leu Leu
             250                 255                 260

 cct cgc tta gat cca gga cag aga gga aac aag ctt ccc acg ggg gaa      931
 Pro Arg Leu Asp Pro Gly Gln Arg Gly Asn Lys Leu Pro Thr Gly Glu
         265                 270                 275

 caa ggc ctg gat gag gat gtt gat ggg gtc tgt gaa agc cac gca gcc      979
 Gln Gly Leu Asp Glu Asp Val Asp Gly Val Cys Glu Ser His Ala Ala
     280                 285                 290

 cct ggt ctg gaa tgc agt tca ggc tca gca aac tgt cag ggt gct ggc     1027
 Pro Gly Leu Glu Cys Ser Ser Gly Ser Ala Asn Cys Gln Gly Ala Gly
 295                 300                 305                 310

 ccc tct gca gat gga atc agc tcc agg ctg aca cca gca gag tcc tgc     1075
 Pro Ser Ala Asp Gly Ile Ser Ser Arg Leu Thr Pro Ala Glu Ser Cys
                 315                 320                 325

 atg ggg ctc gtg agg atg aat ctc tac act cac tgc gtc aaa ggg ctg     1123
 Met Gly Leu Val Arg Met Asn Leu Tyr Thr His Cys Val Lys Gly Leu
             330                 335                 340

 atg ctg tcc ctg ctg gct gag gag ccg ctg ctg gga gac agc gca gcc     1171
 Met Leu Ser Leu Leu Ala Glu Glu Pro Leu Leu Gly Asp Ser Ala Ala
         345                 350                 355

 ata gag gaa gtg tac cac agc agc ctg gct tca ctg aat ggg ctg gaa     1219
 Ile Glu Glu Val Tyr His Ser Ser Leu Ala Ser Leu Asn Gly Leu Glu
     360                 365                 370

 gtc cac ctg aaa gag acg ctg ccc agg gat gag gca gcc tcc acg agc     1267
 Val His Leu Lys Glu Thr Leu Pro Arg Asp Glu Ala Ala Ser Thr Ser
 375                 380                 385                 390

 agc acc tac aac ttc aca tat tac gac cgc att cag agc ttg ctg atg     1315
 Ser Thr Tyr Asn Phe Thr Tyr Tyr Asp Arg Ile Gln Ser Leu Leu Met
                 395                 400                 405

 gca aac ctg ccg cag gtg gcc acc ccg cat gat cgc cgc ttc ctc cag     1363
 Ala Asn Leu Pro Gln Val Ala Thr Pro His Asp Arg Arg Phe Leu Gln
             410                 415                 420

 gcc gtc agc ctg atg cat agc gaa ttt gcc cag ctg ccc gcg ctt tat     1411
 Ala Val Ser Leu Met His Ser Glu Phe Ala Gln Leu Pro Ala Leu Tyr
         425                 430                 435

 gaa atg act gtc aga aat gcc tcc acg gct gtg tac gcc tgt tgc aac     1459
 Glu Met Thr Val Arg Asn Ala Ser Thr Ala Val Tyr Ala Cys Cys Asn
     440                 445                 450

 ccc atc cag gag aca tat ttc cag cag ctg gca cct gca gca cgg agc     1507
 Pro Ile Gln Glu Thr Tyr Phe Gln Gln Leu Ala Pro Ala Ala Arg Ser
 455                 460                 465                 470

 tcc ggc ttc cca aac cct cag gat ggc gcc ttc agc ctc tcc ggc aaa     1555
 Ser Gly Phe Pro Asn Pro Gln Asp Gly Ala Phe Ser Leu Ser Gly Lys
                 475                 480                 485

 gca aag cag aag ctg ctg aag cac ggg gtg aac ttg ctc tga actgcac     1604
 Ala Lys Gln Lys Leu Leu Lys His Gly Val Asn Leu Leu 
             490                 495

 ccaggaggtg actgggaagg agaaaaccag caaaggaagc tctgcctttt ataattgaaa   1664

 aggcccctct attttatttt tcttgaaaac attccctttt ttaggaacca aatgatattt   1724

 gagtttttgt tattcctttt gcagattggg atgtgttttg ggggcagggg ttagttcttc   1784

 aggtcggcag acccagagca cttgataaag aactgtattt aatcggtagt gttggggccg   1844

 ggacgggctt ggctccctct ctgccatact gagcctgagg tatttcatat ctcctgctgt   1904

 tccatcccag cttgaattgg tgccacaagc ttccaagttg gcattttttc tagaacctga   1964

 tcgtccacta gcccagagtg tgtgtgttca acccccacac caggtggtgg taggcggtgt   2024

 gactgcacag cgaggtgccg gatctgtgag caggccgact ccactcccac gccgcaggta   2084

 ggtttctcca gtgcgctctt gctgggaggt ccggatcgtt cctgcaggga agcggcagca   2144

 cacggagacc acttggttga attctgttgg aactctactc aaatctaggg gcgtcttctt   2204

 tggacccaca atgggggcaa gccttaataa tatggaaggg agtttgggct ttagagatcc   2264

 ctttataaaa gctctggggg ctgagccctg agaattcagt gacaacagga ccaacctgcg   2324

 ctgcctttga ctacaagtgg gccgtgcagc tggttcctct cgagcgagtg tccctaaata   2384

 ggagtttaca agatgtctgg gggtaaaagc actgtgcttt tcagtggtgg ctgcgtgaaa   2444

 gggagcgaca ctcagctgtg tgttcctggg cttgtgtggt acttagaacc tcagttctat   2504

 tacgttatag tcagacattt ttttgacagt atgagacaga ctgcaggatg aaaatatttg   2564

 tcaaaatctt aactgaatgt ttactggaag tacttgagat tccatttgag agttgtattg   2624

 ttaataattt catgtcagtg aactgatatc tgatgtttat gatatggtgt ctttttcttg   2684

 aaacaagctt ccaagggcta gaaataaaat agccaaaaaa tgctggaaaa aaaaaaaa     2742




      <210> 11
      <211> 745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(691)

      <400> 11
 cccactgacc ccaccggacc caggcgcggc ctccgccaca gccacagccc ctgcccctgc     60

 tgcggcgcgg cgaggcgagg cg atg gcc aag gtg tcg gtg ctg aac gtg gcg     112
                          Met Ala Lys Val Ser Val Leu Asn Val Ala
                            1               5                  10

 gtc ctg gag aac ccg agc cct ttc cac agc ccc ttc cgg ttc gag atc      160
 Val Leu Glu Asn Pro Ser Pro Phe His Ser Pro Phe Arg Phe Glu Ile
                  15                  20                  25

 agc ttc gag tgc agt gaa gcc ctg gcg gac gac ctg gag tgg aag atc      208
 Ser Phe Glu Cys Ser Glu Ala Leu Ala Asp Asp Leu Glu Trp Lys Ile
              30                  35                  40

 att tat gtt ggc tcg gct gag agt gag gaa ttt gat cag atc cta gac      256
 Ile Tyr Val Gly Ser Ala Glu Ser Glu Glu Phe Asp Gln Ile Leu Asp
          45                  50                  55

 tcg gtg ctg gtg ggc cct gtg cca gca ggg aga cac atg ttt gtc ttt      304
 Ser Val Leu Val Gly Pro Val Pro Ala Gly Arg His Met Phe Val Phe
      60                  65                  70

 cag gcc gac gcc ccc aac cca tcc ctc atc cca gag gct gat gcc gtg      352
 Gln Ala Asp Ala Pro Asn Pro Ser Leu Ile Pro Glu Ala Asp Ala Val
  75                  80                  85                  90

 ggt gtg act gtg gtc ctc atc acc tgc acc tac cat gga cag gag ttc      400
 Gly Val Thr Val Val Leu Ile Thr Cys Thr Tyr His Gly Gln Glu Phe
                  95                 100                 105

 atc cga gtg ggc tac tac gtc aac aac gag tac ctc aac cct gag ctg      448
 Ile Arg Val Gly Tyr Tyr Val Asn Asn Glu Tyr Leu Asn Pro Glu Leu
             110                 115                 120

 cgt gag aac ccg ccc atg aag cca gat ttc tcc cag ctc cag cgg aac      496
 Arg Glu Asn Pro Pro Met Lys Pro Asp Phe Ser Gln Leu Gln Arg Asn
         125                 130                 135

 atc ttg gcc tcg aac ccc cgg gtg acc cgc ttc cat atc aac tgg gac      544
 Ile Leu Ala Ser Asn Pro Arg Val Thr Arg Phe His Ile Asn Trp Asp
     140                 145                 150

 aac aac atg gac agg ctg gag gcc ata gag acc cag gac ccc tcc ctg      592
 Asn Asn Met Asp Arg Leu Glu Ala Ile Glu Thr Gln Asp Pro Ser Leu
 155                 160                 165                 170

 ggc tgc ggc ctc cca ctc aac tgc act cct atc aag ggc ttg ggg ctc      640
 Gly Cys Gly Leu Pro Leu Asn Cys Thr Pro Ile Lys Gly Leu Gly Leu
                 175                 180                 185

 cct ggc tgc atc cct ggc ctc ctc cct gag aac tcc atg gac tgc atc      688
 Pro Gly Cys Ile Pro Gly Leu Leu Pro Glu Asn Ser Met Asp Cys Ile
             190                 195                 200

 taa ctgc aggaacccag agtgtcccag cacgccggga ggggcaacca ggcctcccag      745
 






      <210> 12
      <211> 761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(707)

      <400> 12
 ggacgctgag gggcggaggc gggagaggcg agctcgcg    atg agt ggt ctc ggc      53
                                              Met Ser Gly Leu Gly
                                                1               5

 agg ctc ttc ggg aag ggg aag aag gag aaa ggg cca acc cct gaa gaa      101
 Arg Leu Phe Gly Lys Gly Lys Lys Glu Lys Gly Pro Thr Pro Glu Glu
                  10                  15                  20

 gca ata cag aaa ctg aag gag aca gag aag ata ctg atc aag aaa cag      149
 Ala Ile Gln Lys Leu Lys Glu Thr Glu Lys Ile Leu Ile Lys Lys Gln
              25                  30                  35

 gaa ttt ttg gag cag aag att caa cag gag cta caa aca gcc aag aag      197
 Glu Phe Leu Glu Gln Lys Ile Gln Gln Glu Leu Gln Thr Ala Lys Lys
          40                  45                  50

 tat ggg acc aag aat aag aga gct gcc cta cag gct ttg cgg agg aag      245
 Tyr Gly Thr Lys Asn Lys Arg Ala Ala Leu Gln Ala Leu Arg Arg Lys
      55                  60                  65

 aaa aga ttc gaa cag cag ctg gca caa act gac ggg aca tta tcc acc      293
 Lys Arg Phe Glu Gln Gln Leu Ala Gln Thr Asp Gly Thr Leu Ser Thr
  70                  75                  80                  85

 ctg gag ttt cag cgt gag gcc att gag aat gcc act acc aat gca gaa      341
 Leu Glu Phe Gln Arg Glu Ala Ile Glu Asn Ala Thr Thr Asn Ala Glu
                  90                  95                 100

 gtc ctt cgt acc atg gag ctt gct gcc caa agc atg aag aag gcc tac      389
 Val Leu Arg Thr Met Glu Leu Ala Ala Gln Ser Met Lys Lys Ala Tyr
             105                 110                 115

 cag gac atg gac att gac aag gta gat gaa ctg atg act gac atc acg      437
 Gln Asp Met Asp Ile Asp Lys Val Asp Glu Leu Met Thr Asp Ile Thr
         120                 125                 130

 gaa caa cag gag gtg gcc cag cag atc tca gat gcc att tct cgg cct      485
 Glu Gln Gln Glu Val Ala Gln Gln Ile Ser Asp Ala Ile Ser Arg Pro
     135                 140                 145

 atg ggc ttt gga gat gat gtg gat gag gat gaa ctg ctg gag gag cta      533
 Met Gly Phe Gly Asp Asp Val Asp Glu Asp Glu Leu Leu Glu Glu Leu
 150                 155                 160                 165

 gag gag ctg gag cag gag gaa ttg gcc cag gag ttg tta aat gtg ggc      581
 Glu Glu Leu Glu Gln Glu Glu Leu Ala Gln Glu Leu Leu Asn Val Gly
                 170                 175                 180

 gac aag gaa gaa gaa ccc tca gtc aaa ttg cct agt gta cct tct act      629
 Asp Lys Glu Glu Glu Pro Ser Val Lys Leu Pro Ser Val Pro Ser Thr
             185                 190                 195

 cat ctg ccg gca ggg cca gct ccc aaa gtg gat gaa gat gaa gaa gca      677
 His Leu Pro Ala Gly Pro Ala Pro Lys Val Asp Glu Asp Glu Glu Ala
         200                 205                 210

 cta aag cag ttg gct gag tgg gta tcc tga t aaatctgggc ttgtcttcct      728
 Leu Lys Gln Leu Ala Glu Trp Val Ser 
     215                 220

 aatgctacct ttgttggtcc tttcttcctt aag                                 761




      <210> 13
      <211> 2071
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(1364)

      <400> 13
 gctacagcct gcaccacgct acc    atg aag cgg cag gcg gcc gag gag gcc      50
                              Met Lys Arg Gln Ala Ala Glu Glu Ala
                                1               5

 tgc atc ctg cga ggt ggg gcg ctc agc acc gtg cgt gcg ggc gcc gag       98
 Cys Ile Leu Arg Gly Gly Ala Leu Ser Thr Val Arg Ala Gly Ala Glu
  10                  15                  20                  25

 ctg cgc gct gtg ctc gcg ctc ctg cgg gca ggc cca ggg ccc gga ggg      146
 Leu Arg Ala Val Leu Ala Leu Leu Arg Ala Gly Pro Gly Pro Gly Gly
                  30                  35                  40

 ggc tcc aaa gac ctg ctg ttc tgg gtc gca ctg gag cgc agg cgt tcc      194
 Gly Ser Lys Asp Leu Leu Phe Trp Val Ala Leu Glu Arg Arg Arg Ser
              45                  50                  55

 cac tgc acc ctg gag aac gag cct ttg cgg ggt ttc tcc tgg ctg tcc      242
 His Cys Thr Leu Glu Asn Glu Pro Leu Arg Gly Phe Ser Trp Leu Ser
          60                  65                  70

 tcc gac ccc ggc ggt ctc gaa agc gac acg ctg cag tgg gtg gag gag      290
 Ser Asp Pro Gly Gly Leu Glu Ser Asp Thr Leu Gln Trp Val Glu Glu
      75                  80                  85

 ccc caa cgc tcc tgc acc gcg cgg aga tgc gcg gta ctc cag gcc acc      338
 Pro Gln Arg Ser Cys Thr Ala Arg Arg Cys Ala Val Leu Gln Ala Thr
  90                  95                 100                 105

 ggt ggg gtc gag ccc gca ggc tgg aag gag atg cga tgc cac ctg cgc      386
 Gly Gly Val Glu Pro Ala Gly Trp Lys Glu Met Arg Cys His Leu Arg
                 110                 115                 120

 gcc aac ggc tac ctg tgc aag tac cag ttt gag gtc ttg tgt cct gcg      434
 Ala Asn Gly Tyr Leu Cys Lys Tyr Gln Phe Glu Val Leu Cys Pro Ala
             125                 130                 135

 ccg cgc ccc ggg gcc gcc tct aac ttg agc tat cgc gcg ccc ttc cag      482
 Pro Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr Arg Ala Pro Phe Gln
         140                 145                 150

 ctg cac agc gcc gct ctg gac ttc agt cca cct ggg acc gag gtg agt      530
 Leu His Ser Ala Ala Leu Asp Phe Ser Pro Pro Gly Thr Glu Val Ser
     155                 160                 165

 gcg ctc tgc cgg gga cag ctc ccg atc tca gtt act tgc atc gcg gac      578
 Ala Leu Cys Arg Gly Gln Leu Pro Ile Ser Val Thr Cys Ile Ala Asp
 170                 175                 180                 185

 gaa atc ggc gct cgc tgg gac aaa ctc tcg ggc gat gtg ttg tgt ccc      626
 Glu Ile Gly Ala Arg Trp Asp Lys Leu Ser Gly Asp Val Leu Cys Pro
                 190                 195                 200

 tgc ccc ggg agg tac ctc cgt gct ggc aaa tgc gca gag ctc cct aac      674
 Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys Cys Ala Glu Leu Pro Asn
             205                 210                 215

 tgc cta gac gac ttg gga ggc ttt gcc tgc gaa tgt gct acg ggc ttc      722
 Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys Glu Cys Ala Thr Gly Phe
         220                 225                 230

 gag ctg ggg aag gac ggc cgc tct tgt gtg acc agt ggg gaa gga cag      770
 Glu Leu Gly Lys Asp Gly Arg Ser Cys Val Thr Ser Gly Glu Gly Gln
     235                 240                 245

 ccg acc ctt ggg ggg acc ggg gtg ccc acc agg cgc ccg ccg gcc act      818
 Pro Thr Leu Gly Gly Thr Gly Val Pro Thr Arg Arg Pro Pro Ala Thr
 250                 255                 260                 265

 gca acc agc ccc gtg ccg cag aga aca tgg cca atc agg gtc gac gag      866
 Ala Thr Ser Pro Val Pro Gln Arg Thr Trp Pro Ile Arg Val Asp Glu
                 270                 275                 280

 aag ctg gga gag aca cca ctt gtc cct gaa caa gac aat tca gta aca      914
 Lys Leu Gly Glu Thr Pro Leu Val Pro Glu Gln Asp Asn Ser Val Thr
             285                 290                 295

 tct att cct gag att cct cga tgg gga tca cag agc acg atg tct acc      962
 Ser Ile Pro Glu Ile Pro Arg Trp Gly Ser Gln Ser Thr Met Ser Thr
         300                 305                 310

 ctt caa atg tcc ctt caa gcc gag tca aag gcc act atc acc cca tca     1010
 Leu Gln Met Ser Leu Gln Ala Glu Ser Lys Ala Thr Ile Thr Pro Ser
     315                 320                 325

 ggg agc gtg att tcc aag ttt aat tct acg act tcc tct gcc act cct     1058
 Gly Ser Val Ile Ser Lys Phe Asn Ser Thr Thr Ser Ser Ala Thr Pro
 330                 335                 340                 345

 cag gct ttc gac tcc tcc tct gcc gtg gtc ttc ata ttt gtg agc aca     1106
 Gln Ala Phe Asp Ser Ser Ser Ala Val Val Phe Ile Phe Val Ser Thr
                 350                 355                 360

 gca gta gta gtg ttg gtg atc ttg acc atg aca gta ctg ggg ctt gtc     1154
 Ala Val Val Val Leu Val Ile Leu Thr Met Thr Val Leu Gly Leu Val
             365                 370                 375

 aag ctc tgc ttt cac gaa agc ccc tct tcc cag cca agg aag gag tct     1202
 Lys Leu Cys Phe His Glu Ser Pro Ser Ser Gln Pro Arg Lys Glu Ser
         380                 385                 390

 atg ggc ccg ccg ggc ctg gag agt gat cct gag ccc gct gct ttg ggc     1250
 Met Gly Pro Pro Gly Leu Glu Ser Asp Pro Glu Pro Ala Ala Leu Gly
     395                 400                 405

 tcc agt tct gca cat tgc aca aac aat ggg gtg aaa gtc ggg gac tgt     1298
 Ser Ser Ser Ala His Cys Thr Asn Asn Gly Val Lys Val Gly Asp Cys
 410                 415                 420                 425

 gat ctg cgg gac aga gca gag ggt gcc ttg ctg gcg gag tcc cct ctt     1346
 Asp Leu Arg Asp Arg Ala Glu Gly Ala Leu Leu Ala Glu Ser Pro Leu
                 430                 435                 440

 ggc tct agt gat gca tag ggaaac aggggacatg ggcactcctg tgaacagttt     1400
 Gly Ser Ser Asp Ala 
             445

 ttcacttttg atgaaacggg gaaccaagag gaacttactt gtgtaactga caatttctgc   1460

 agaaatcccc cttcctctaa attcccttta ctccactgag gagctaaatc agaactgcac   1520

 actccttccc tgatgataga ggaagtggaa gtgcctttag gatggtgata ctgggggacc   1580

 gggtagtgct ggggagagat attttcttat gtttattcgg agaatttgga gaagtgattg   1640

 aacttttcaa gacattggaa acaaatagaa cacaatataa tttacattaa aaaataattt   1700

 ctaccaaaat ggaaaggaaa tgttctatgt tgttcaggct aggagtatat tggttcgaaa   1760

 tcccagggaa aaaaataaaa ataaaaaatt aaaggattgt tgataaccca gactcaaata   1820

 tcattgcctt cctccaggag taaataggaa cagctgaggg catgctggga gtaagcagca   1880

 agagtgcatt ctgcttttag attgagggag aggtccttaa gttcctcgaa tgagacacag   1940

 atctttaaga actagtaact ttttcattga ttcttttatc ctttcttttc aaagtcactg   2000

 ctacttgtgt gctttgctat aaatcgaaag tgtagtgttg ccagaattgc tggctctgga   2060

 agaaattaca g                                                        2071




      <210> 14
      <211> 2047
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(1928)

      <400> 14
 tgtcgttgtt ctgaggctac caggagctag agatgctgtt attctatcgt atgtgagaag     60

 tcggcccaga g atg gaa aac ttt att ctg tat gag gag atc gga aga gga     110
              Met Glu Asn Phe Ile Leu Tyr Glu Glu Ile Gly Arg Gly
                1               5                  10

 agc aag act gtt gtc tat aaa ggg cga cgg aag gga aca atc aat ttt      158
 Ser Lys Thr Val Val Tyr Lys Gly Arg Arg Lys Gly Thr Ile Asn Phe
      15                  20                  25

 gta gcc att ctt tgt act gat aag tgc aaa agg cct gaa ata acc aac      206
 Val Ala Ile Leu Cys Thr Asp Lys Cys Lys Arg Pro Glu Ile Thr Asn
  30                  35                  40                  45

 tgg gtc cgt ctc acc cgt gaa ata aaa cac aag aat att gta act ttt      254
 Trp Val Arg Leu Thr Arg Glu Ile Lys His Lys Asn Ile Val Thr Phe
                  50                  55                  60

 cat gaa tgg tat gaa aca agc aac cac ctc tgg cta gtg gtg gaa ctc      302
 His Glu Trp Tyr Glu Thr Ser Asn His Leu Trp Leu Val Val Glu Leu
              65                  70                  75

 tgc aca ggt ggt tcc tta aaa aca gtt att gct caa gat gaa aac ctc      350
 Cys Thr Gly Gly Ser Leu Lys Thr Val Ile Ala Gln Asp Glu Asn Leu
          80                  85                  90

 cca gaa gat gtt gtg aga gaa ttt gga att gac ctg att agt gga tta      398
 Pro Glu Asp Val Val Arg Glu Phe Gly Ile Asp Leu Ile Ser Gly Leu
      95                 100                 105

 cat cat ctt cat aaa ctt ggc att ctc ttt tgt gac att tct cct agg      446
 His His Leu His Lys Leu Gly Ile Leu Phe Cys Asp Ile Ser Pro Arg
 110                 115                 120                 125

 aag ata ctc ttg gaa ggg cct ggc aca ctg aag ttt agc aac ttt tgc      494
 Lys Ile Leu Leu Glu Gly Pro Gly Thr Leu Lys Phe Ser Asn Phe Cys
                 130                 135                 140

 ttg gca aaa gtg gaa ggt gaa aat ttg gaa gag ttc ttt gct ttg gtg      542
 Leu Ala Lys Val Glu Gly Glu Asn Leu Glu Glu Phe Phe Ala Leu Val
             145                 150                 155

 gca gca gag gaa gga gga ggt gat aat ggg gaa aat gtc ctg aag aaa      590
 Ala Ala Glu Glu Gly Gly Gly Asp Asn Gly Glu Asn Val Leu Lys Lys
         160                 165                 170

 agc atg aaa agt aga gtc aaa gga tct cct gta tat acg gca cca gaa      638
 Ser Met Lys Ser Arg Val Lys Gly Ser Pro Val Tyr Thr Ala Pro Glu
     175                 180                 185

 gtt gtg agg ggt gct gac ttt tcc atc tcc agt gac ctc tgg tct ttg      686
 Val Val Arg Gly Ala Asp Phe Ser Ile Ser Ser Asp Leu Trp Ser Leu
 190                 195                 200                 205

 ggc tgt ctg ctt tat gaa atg ttt tca gga aaa cct cca ttc ttc tca      734
 Gly Cys Leu Leu Tyr Glu Met Phe Ser Gly Lys Pro Pro Phe Phe Ser
                 210                 215                 220

 gaa agt att tca gaa tta act gaa aag atc tta tgt gaa gat cct ttg      782
 Glu Ser Ile Ser Glu Leu Thr Glu Lys Ile Leu Cys Glu Asp Pro Leu
             225                 230                 235

 cca cct att ccg aaa gat tct tct cgt cct aaa gct tct tca gat ttt      830
 Pro Pro Ile Pro Lys Asp Ser Ser Arg Pro Lys Ala Ser Ser Asp Phe
         240                 245                 250

 att aat ttg ctt gat ggg tta ctt caa aga gat cct cag aaa aga ttg      878
 Ile Asn Leu Leu Asp Gly Leu Leu Gln Arg Asp Pro Gln Lys Arg Leu
     255                 260                 265

 act tgg aca agg cta ctg cag cat tca ttt tgg aag aaa gct ttt gct      926
 Thr Trp Thr Arg Leu Leu Gln His Ser Phe Trp Lys Lys Ala Phe Ala
 270                 275                 280                 285

 gga gca gat cag gaa tca agc gtc gaa gat ctc agt ctc agc aga aac      974
 Gly Ala Asp Gln Glu Ser Ser Val Glu Asp Leu Ser Leu Ser Arg Asn
                 290                 295                 300

 act atg gag tgt tct ggg cca caa gat tcc aag gag ctt ttg cag aac     1022
 Thr Met Glu Cys Ser Gly Pro Gln Asp Ser Lys Glu Leu Leu Gln Asn
             305                 310                 315

 tct cag agt aga caa gca aaa ggg cac aag agt ggt caa cca cta ggt     1070
 Ser Gln Ser Arg Gln Ala Lys Gly His Lys Ser Gly Gln Pro Leu Gly
         320                 325                 330

 cac tct ttc aga cta gaa aat cca act gag ttt cgg cct aag agt act     1118
 His Ser Phe Arg Leu Glu Asn Pro Thr Glu Phe Arg Pro Lys Ser Thr
     335                 340                 345

 ctt gag ggc caa ttg aat gaa tcc atg ttt ctt ctc agt tct cgt cct     1166
 Leu Glu Gly Gln Leu Asn Glu Ser Met Phe Leu Leu Ser Ser Arg Pro
 350                 355                 360                 365

 act ccc aga act agc act gca gtg gaa gta agt cct ggt gag gat atg     1214
 Thr Pro Arg Thr Ser Thr Ala Val Glu Val Ser Pro Gly Glu Asp Met
                 370                 375                 380

 act cac tgt tca cca cag aag act tct cct ctg acc aag att aca agt     1262
 Thr His Cys Ser Pro Gln Lys Thr Ser Pro Leu Thr Lys Ile Thr Ser
             385                 390                 395

 gga cac ctg agt cag cag gac ctg gaa tcc cag atg aga gag ctt atc     1310
 Gly His Leu Ser Gln Gln Asp Leu Glu Ser Gln Met Arg Glu Leu Ile
         400                 405                 410

 tac acg gac tca gat ctt gtt gtc acc ccc att atc gac aat cca aag     1358
 Tyr Thr Asp Ser Asp Leu Val Val Thr Pro Ile Ile Asp Asn Pro Lys
     415                 420                 425

 ata atg aaa cag cca cca gtt aaa ttt gat gca aaa ata ttg cat cta     1406
 Ile Met Lys Gln Pro Pro Val Lys Phe Asp Ala Lys Ile Leu His Leu
 430                 435                 440                 445

 cca aca tat tca gtg gat aag tta tta ttt ctg aaa gat caa gat tgg     1454
 Pro Thr Tyr Ser Val Asp Lys Leu Leu Phe Leu Lys Asp Gln Asp Trp
                 450                 455                 460

 aat gac ttt ttg caa caa gtg tgc tcg cag atc gac tcc act gag aag     1502
 Asn Asp Phe Leu Gln Gln Val Cys Ser Gln Ile Asp Ser Thr Glu Lys
             465                 470                 475

 agc atg ggg gcc tcc cga gcc aag ctg aat ctc ctt tgc tat ttg tgc     1550
 Ser Met Gly Ala Ser Arg Ala Lys Leu Asn Leu Leu Cys Tyr Leu Cys
         480                 485                 490

 gtg gtg gct ggt cac cag gag gtg gcc acc agg ctc ctc cat tcc ccc     1598
 Val Val Ala Gly His Gln Glu Val Ala Thr Arg Leu Leu His Ser Pro
     495                 500                 505

 ctg ttc caa ttg cta atc cag cat ttg cgg ata gct cca aac tgg gat     1646
 Leu Phe Gln Leu Leu Ile Gln His Leu Arg Ile Ala Pro Asn Trp Asp
 510                 515                 520                 525

 ata cgg gcc aag gtt gct cac gtg att ggt tta ctg gct tcg cac aca     1694
 Ile Arg Ala Lys Val Ala His Val Ile Gly Leu Leu Ala Ser His Thr
                 530                 535                 540

 gct gag ctc cag gaa aat aca cct gtt gtt gag gca att gtt ctc tta     1742
 Ala Glu Leu Gln Glu Asn Thr Pro Val Val Glu Ala Ile Val Leu Leu
             545                 550                 555

 act gaa tta att agg gaa aac ttc agg aac agc aaa tta aaa cag tgc     1790
 Thr Glu Leu Ile Arg Glu Asn Phe Arg Asn Ser Lys Leu Lys Gln Cys
         560                 565                 570

 ctt tta cca acc ctt ggg gag ctg atc tat ctt gta gcc ccc cag gaa     1838
 Leu Leu Pro Thr Leu Gly Glu Leu Ile Tyr Leu Val Ala Pro Gln Glu
     575                 580                 585

 gaa aaa aaa aag aac cct aga gag tgc tgg gct gtt ccc ttg gct gca     1886
 Glu Lys Lys Lys Asn Pro Arg Glu Cys Trp Ala Val Pro Leu Ala Ala
 590                 595                 600                 605

 tac aca gtg cta atg agg tgc ctt cgg gaa ggg gaa ctc tga atcctct     1935
 Tyr Thr Val Leu Met Arg Cys Leu Arg Glu Gly Glu Leu 
                 610                 615

 acggcctatt attataaaat gtttcaaaga ttagaaaaga aaagaaagct gtaataatca   1995

 cctttgtttc catcacctag attaaccagt aaacatttaa aaaaaaaaaa aa           2047




      <210> 15
      <211> 1148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (337)..(1098)

      <400> 15
 accctagttc gggcgccaga gcaacgcagt tccgagggca gatctccaag gggcggaggc     60

 agagccgcgg gtggatcttt aactcaagac tagcatgaag agttgccttc tggcctgccc    120

 tgagtctcct caaataacaa caggcccttc caccgcagcc atccgcacgg gaggcctcgc    180

 gattgctcgg aaccatcccg caggagttca gctgatattt tctagtgtgg ggcgagagat    240

 tttgtggagc gcatttaagg ggtttttgtt gtgactgctg ccttgtatat atttattttc    300

 tttcttggaa ctgggcctcg ccctcctccc actgac  atg atg gcc cag tcc aag     354
                                          Met Met Ala Gln Ser Lys
                                            1               5

 gcc aat ggc tcg cac tat gcg ctg acc gcc atc ggc ctg ggg atg ctg      402
 Ala Asn Gly Ser His Tyr Ala Leu Thr Ala Ile Gly Leu Gly Met Leu
              10                  15                  20

 gtc ctt ggg gtg atc atg gcc atg tgg aac ctg gta ccc ggc ttc agc      450
 Val Leu Gly Val Ile Met Ala Met Trp Asn Leu Val Pro Gly Phe Ser
          25                  30                  35

 gcg gcc gag aag cca aca gct cag ggc agc aac aag acc gag gtg ggt      498
 Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser Asn Lys Thr Glu Val Gly
      40                  45                  50

 ggc ggc atc ctc aag agc aag acc ttc tct gtg gcc tac gtg ctg gtc      546
 Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser Val Ala Tyr Val Leu Val
  55                  60                  65                  70

 ggg gcc ggg gtg atg ctg ctg ctg ctt tct atc tgc ctg agt atc agg      594
 Gly Ala Gly Val Met Leu Leu Leu Leu Ser Ile Cys Leu Ser Ile Arg
                  75                  80                  85

 gat aag agg aag cag cgg cag ggc gag gac ctg gcc cat gtc cag cac      642
 Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp Leu Ala His Val Gln His
              90                  95                 100

 ccg aca ggc gct ggg cct cac gcc cag gag gaa gac agc cag gag gaa      690
 Pro Thr Gly Ala Gly Pro His Ala Gln Glu Glu Asp Ser Gln Glu Glu
         105                 110                 115

 gaa gag gag gat gag gag gct gcc tca agg tac tat gtt ccc agc tac      738
 Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg Tyr Tyr Val Pro Ser Tyr
     120                 125                 130

 gag gaa gtg atg aac aca aac tac tca gaa gca agg gga gag gag cag      786
 Glu Glu Val Met Asn Thr Asn Tyr Ser Glu Ala Arg Gly Glu Glu Gln
 135                 140                 145                 150

 aac ccg agg ttg agc atc tct ctc ccg tcc tat gag tca ctg acg ggg      834
 Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser Tyr Glu Ser Leu Thr Gly
                 155                 160                 165

 ctc gac gag acc acc ccc aca tcc acc agg gct gac gtg gag gcc agc      882
 Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg Ala Asp Val Glu Ala Ser
             170                 175                 180

 cct ggg aac ccc cct gac agg cag aac tct aag ttg gcc aaa cga ctg      930
 Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser Lys Leu Ala Lys Arg Leu
         185                 190                 195

 aaa ccg ctg aaa gtt cga agg att aaa tct gaa aag ctt cac ctc aaa      978
 Lys Pro Leu Lys Val Arg Arg Ile Lys Ser Glu Lys Leu His Leu Lys
     200                 205                 210

 gac ttt agg atc aac ctc cca gac aaa aac gtc cct cct ccc tcg ata     1026
 Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn Val Pro Pro Pro Ser Ile
 215                 220                 225                 230

 gag cct ttg act cct cca ccg cag tat gat gaa gtc cag gag aag gcc     1074
 Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp Glu Val Gln Glu Lys Ala
                 235                 240                 245

 ccc gac acc cgg ccg ccc gac tga atggccccac ttgagccacg ctccctcctg    1128
 Pro Asp Thr Arg Pro Pro Asp 
             250

 tctctcacac ctttcacccc                                               1148




      <210> 16
      <211> 1249
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (243)..(1235)

      <400> 16
 gtcgacgatt tcgtgggagt aagaggtggg gaggaggagg cacagttaat ggatctgtaa     60

 acttgcaccc tctttcagag tggtaacatg gaagacagca caaagtggat ccatactctg    120

 aaatgcagta actctgatgc ttgaatttgt ctcccttctt gccagaaagg attctaataa    180

 ctcggtgtca aagccaagac ataaactcaa ccccttctct tccaaaagct tcacgttaca    240

 gc   atg gaa gct gtt gcc aag ttt gat ttc act gct tca ggt gag gat     287
      Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp
        1               5                  10                  15

 gaa ctg agc ttt cac act gga gat gtt ttg aag att tta agt aac caa      335
 Glu Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln
                  20                  25                  30

 gag gag tgg ttt aag gcg gag ctt ggg agc cag gaa gga tat gtg ccc      383
 Glu Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro
              35                  40                  45

 aag aat ttc ata gac atc cag ttt ccc aaa tgg ttt cac gaa ggc ctc      431
 Lys Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu
          50                  55                  60

 tct cga cac cag gca gag aac tta ctc atg ggc aag gag gtt ggc ttc      479
 Ser Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe
      65                  70                  75

 ttc atc atc cgg gcc agc cag agc tcc cca ggg gac ttc tcc atc tct      527
 Phe Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser
  80                  85                  90                  95

 gtc agg cat gag gat gac gtt caa cac ttc aag gtc atg cga gac aac      575
 Val Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn
                 100                 105                 110

 aag ggt aat tac ttt ctg tgg act gag aag ttt cca tcc cta aat aag      623
 Lys Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys
             115                 120                 125

 ctg gta gac tac tac agg aca aat tcc atc tcc aga cag aag cag atc      671
 Leu Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile
         130                 135                 140

 ttc ctt aga gac aga acc cga gaa gac cag ggt cac cgg ggc aac agc      719
 Phe Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser
     145                 150                 155

 ctg gac cgg agg tcc cag gga ggc cca cac ctc agt ggg gct gtg gga      767
 Leu Asp Arg Arg Ser Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly
 160                 165                 170                 175

 gaa gaa atc cga cct tcg atg aac cgg aag ctg tcg gat cac ccc ccg      815
 Glu Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro
                 180                 185                 190

 acc ctt ccc ctg cag cag cac cag cac cag cca cag cct ccg caa tat      863
 Thr Leu Pro Leu Gln Gln His Gln His Gln Pro Gln Pro Pro Gln Tyr
             195                 200                 205

 gcc cca gcg ccc cag cag ctg cag cag ccc cca cag cag cga tat ctg      911
 Ala Pro Ala Pro Gln Gln Leu Gln Gln Pro Pro Gln Gln Arg Tyr Leu
         210                 215                 220

 cag cac cac cat ttc cac cag gaa cgc cga gga ggc agc ctt gac ata      959
 Gln His His His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp Ile
     225                 230                 235

 aat gat ggg cat tgt ggc acc ggc ttg ggc agt gaa atg aat gcg gcc     1007
 Asn Asp Gly His Cys Gly Thr Gly Leu Gly Ser Glu Met Asn Ala Ala
 240                 245                 250                 255

 ctc atg cat cgg aga cac aca gac cca gtg cag ctc cag gcg gca ggg     1055
 Leu Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly
                 260                 265                 270

 cga gtg cgg tgg gcc cgg gcg ctg tat gac ttt gaa gcc ctg gag gat     1103
 Arg Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp
             275                 280                 285

 gac gag ctg ggg ttc cac agc ggg gag gtg gtg gag gtc ctg gat agc     1151
 Asp Glu Leu Gly Phe His Ser Gly Glu Val Val Glu Val Leu Asp Ser
         290                 295                 300

 tcc aac cca tcc tgg tgg acc ggc cgc ctg cac aac aag ctg ggc ctc     1199
 Ser Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu
     305                 310                 315

 ttc cct gcc aac tac gtg gca ccc atg acc cga taa actc ttcaggggac     1249
 Phe Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
 320                 325                 330





      <210> 17
      <211> 1168
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(872)

      <220>
      <221> misc_feature
      <222> (1)...(1168)
      <223> n = a,t,c or g

      <400> 17
 ttcgtgggag taagaggtgg ggaggaggag gcacagttaa tggatctgta aacttgcacc     60

 ctctttcaga gtggtaacat ggaagacagc acaaagtgga tccatactct gaaatgcagt    120

 aactctgatg cttgaatttg tctcccttct tgccagaaag gattctaata actcggtgtc    180

 aaagccaaga cataaactca accccttctc ttccaaaagc ttcacgttac agc   atg     236
                                                              Met
                                                                1

 gaa gct gtt gcc aag ttt gat ttc act gct tca ggt gag gat gaa ctg      284
 Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu Leu
               5                  10                  15

 agc ttt cac act gga gat gtt ttg aag att tta agt aac caa gag gag      332
 Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu Glu
          20                  25                  30

 tgg ttt aag gcg gag ctt ggg agc cag gaa gga tat gtg ccc aag aat      380
 Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys Asn
      35                  40                  45

 ttc ata gac atc cag ttt ccc aaa tgg ttt cac gaa ggc ctc tct cga      428
 Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser Arg
  50                  55                  60                  65

 cac cag gca gag aac tta ctc atg ggc aag gag gtt ggc ttc ttc atc      476
 His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe Ile
                  70                  75                  80

 atc cgg gcc agc cag agc tcc cca ggg gac ttc tcc atc tct gtc agg      524
 Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val Arg
              85                  90                  95

 cat gag gat gac gtt caa cac ttc aag gtc atg cga gac aac aag ggt      572
 His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys Gly
         100                 105                 110

 aat tac ttt ctg tgg act gag aag ttt cca tcc cta aat aag ctg gta      620
 Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu Val
     115                 120                 125

 gac tac tac agg aca aat tcc atc tcc aga cag aag cag atc ttc ctt      668
 Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe Leu
 130                 135                 140                 145

 aga gac aga acc cga gaa gac cag cga gtg cgg tgg gcc cgg gcg ctg      716
 Arg Asp Arg Thr Arg Glu Asp Gln Arg Val Arg Trp Ala Arg Ala Leu
                 150                 155                 160

 tat gac ttt gaa gcc ctg gag gat gac gag ctg ggg ttc cac agc ggg      764
 Tyr Asp Phe Glu Ala Leu Glu Asp Asp Glu Leu Gly Phe His Ser Gly
             165                 170                 175

 gag gtg gtg gag gtc ctg gat agc tcc aac cca tcc tgg tgg acc ggc      812
 Glu Val Val Glu Val Leu Asp Ser Ser Asn Pro Ser Trp Trp Thr Gly
         180                 185                 190

 cgc ctg cac aac aag ctg ggc ctc ttc cct gcc aac tac gtg gca ccc      860
 Arg Leu His Asn Lys Leu Gly Leu Phe Pro Ala Asn Tyr Val Ala Pro
     195                 200                 205

 atg acc cga taa act cttcagggga cagaagcttt ttgtctggag ctgcccacaa      915
 Met Thr Arg 
 210

 gaaagagggc aaggaaaaaa ggctggactc catgactata tatacataca tctatctaca    975

 tctgcctgtg tacacacaca actttttata ctagtaattt attggcaatt gggctggtaa   1035

 ttagttgatg caaaagggaa ctcaggtgga gnataatatt gacacttgct tttttgcccc   1095

 cctcnggggt gtgtggaagg cagtggggga gttgggaggg gggcagggaa atgaaatgga   1155

 gttttgtcct ggc                                                      1168




      <210> 18
      <211> 989
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(328)

      <400> 18
 aaacacaaag atcagaagcc ttcagataga gggtggtatt ctggtaaaga agaaagagat     60

 aagggacgct accttgcttt tctggcacag gaagcac atg ata aag cat gct cag     115
                                          Met Ile Lys His Ala Gln
                                            1               5

 agg agc tgg aac aga tat agc tac ctg gtt cgt gta aat aag aat aat      163
 Arg Ser Trp Asn Arg Tyr Ser Tyr Leu Val Arg Val Asn Lys Asn Asn
              10                  15                  20

 caa ggc ccc aga gtg tgt atg ctt cca ggt gga gga gaa agg gga atc      211
 Gln Gly Pro Arg Val Cys Met Leu Pro Gly Gly Gly Glu Arg Gly Ile
          25                  30                  35

 tcc caa aat tta aaa aca aat tgg aag aat aac cag gac agc caa gtg      259
 Ser Gln Asn Leu Lys Thr Asn Trp Lys Asn Asn Gln Asp Ser Gln Val
      40                  45                  50

 aag cag cca cag gga ccc aag cag tcg agg tct tta atg tgc ctg gag      307
 Lys Gln Pro Gln Gly Pro Lys Gln Ser Arg Ser Leu Met Cys Leu Glu
  55                  60                  65                  70

 atg act ctc tgc tat tca tga at cttgctattg cacaaaccct atcaagagct      360
 Met Thr Leu Cys Tyr Ser 
                  75

 gctgcttccc ttccagccag aaaagtggta agcggagcaa gtgccaagca gaacagacct    420

 tatcatctgg gtaacagact tctcagtgtt ggtgctgtgt ctgttagagc cttagagcaa    480

 gttaagcact tccttggtgt gggtaaagaa taaaggggaa agaaactact ttacagcctc    540

 tttttctccc aactcatatt tttgatagga aaaacagaaa acccatccag ttcttcagaa    600

 attgctttct aggcattaat actactttac tatctatact gtttagttat tcctttcttt    660

 acccacctaa actatccatc taatccagga ttccctcact cttttttttt agttactaat    720

 cattttatga aaataatgta tttataagta ttttcttaag gtttgtgaag agtatttgca    780

 ttgtgtcttc attttaatgt gtttgcaatc gctccgctcc aggaagaacg gaaatgctgt    840

 cttgtgagca tgaagtgaac gggctgtttt gctccagcca cttttcttgt acaaccacat    900

 ggatggatta gatgtcctca ggtcttttcc atcttcagtt tctatgactg tggaataaat    960

 gttcagatag aaacttcaaa aaaaaaaaa                                      989




      <210> 19
      <211> 830
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(776)

      <400> 19
 acacgatttc caaaatgaac ttaatctttc atgagaaact gaggatagag atgtcaataa     60

 gcagccactg tttccacctc cccacctgaa gagctaggag gacaactaca aagagcctga    120

 ctgccttctc ggaatgagga gagaggaaaa cagcaacagt atcagttttc aag   atg     176
                                                              Met
                                                                1

 gca gca tct atg cat ggt cag ccc agt cct tct cta gaa gat gca aaa      224
 Ala Ala Ser Met His Gly Gln Pro Ser Pro Ser Leu Glu Asp Ala Lys
               5                  10                  15

 ctc aga aga cca atg gtc ata gaa atc ata gaa aaa aat ttt gac tat      272
 Leu Arg Arg Pro Met Val Ile Glu Ile Ile Glu Lys Asn Phe Asp Tyr
          20                  25                  30

 ctt aga aaa gaa atg aca caa aat ata tat caa atg gcg aca ttt gga      320
 Leu Arg Lys Glu Met Thr Gln Asn Ile Tyr Gln Met Ala Thr Phe Gly
      35                  40                  45

 aca aca gct ggt ttc tct gga ata ttc tca aac ttc ctg ttc aga cgc      368
 Thr Thr Ala Gly Phe Ser Gly Ile Phe Ser Asn Phe Leu Phe Arg Arg
  50                  55                  60                  65

 tgc ttc aag gtt aaa cat gat gct ttg aag aca tat gca tca ttg gct      416
 Cys Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr Ala Ser Leu Ala
                  70                  75                  80

 aca ctt cca ttt ttg tct act gtt gtt act gac aag ctt ttt gta att      464
 Thr Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys Leu Phe Val Ile
              85                  90                  95

 gat gct ttg tat tca gat aat ata agc aag gaa aac tgt gtt ttc aga      512
 Asp Ala Leu Tyr Ser Asp Asn Ile Ser Lys Glu Asn Cys Val Phe Arg
         100                 105                 110

 agc tca ctg att ggc ata gtt tgt ggt gtt ttc tat ccc agt tct ttg      560
 Ser Ser Leu Ile Gly Ile Val Cys Gly Val Phe Tyr Pro Ser Ser Leu
     115                 120                 125

 gct ttt act aaa aat gga cgc ctg gca acc aag tat cat acc gtt cca      608
 Ala Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr His Thr Val Pro
 130                 135                 140                 145

 ctg cca cca aaa gga agg gtt tta atc cat tgg atg acg ctt tgt caa      656
 Leu Pro Pro Lys Gly Arg Val Leu Ile His Trp Met Thr Leu Cys Gln
                 150                 155                 160

 aca caa atg aaa tta atg gcg att cct cta gtc ttt cag att atg ttt      704
 Thr Gln Met Lys Leu Met Ala Ile Pro Leu Val Phe Gln Ile Met Phe
             165                 170                 175

 gga ata tta aat ggt cta tac cat tat gca gta ttt gaa gag aca ctt      752
 Gly Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe Glu Glu Thr Leu
         180                 185                 190

 gag aaa act ata cat gaa gag taa ccaaaaaaat gaatggttgc taacttagca     806
 Glu Lys Thr Ile His Glu Glu 
     195                 200

 aaatgaagtt tctataaaga ggac                                           830




      <210> 20
      <211> 2541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (157)..(2133)

      <400> 20
 acacgcatca aaactagctg cacaaaagaa gattgtaaag atgatatttt aattaactgt     60

 cgacgggctg ccacgtctgt tgctatttgc ccaccaatac catattacct tgctgttggt    120

 tgttctgaca gctcagtacg aatatatgat cggcga  atg ctg ggc aca aga gct     174
                                          Met Leu Gly Thr Arg Ala
                                            1               5

 aca ggg aat tat gca ggt cga ggg act act gga atg gtt gcc cgt ttt      222
 Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr Gly Met Val Ala Arg Phe
              10                  15                  20

 att cct tcc cat ctt aat aat aag tcc tgc aga gtg aca tct ctg tgt      270
 Ile Pro Ser His Leu Asn Asn Lys Ser Cys Arg Val Thr Ser Leu Cys
          25                  30                  35

 tac agt gaa gat ggt caa gag att ctc gtt agt tac tct tca gat tac      318
 Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val Ser Tyr Ser Ser Asp Tyr
      40                  45                  50

 ata tat ctt ttt gac ccg aaa gat gat aca gca cga gaa ctt aaa act      366
 Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr Ala Arg Glu Leu Lys Thr
  55                  60                  65                  70

 cct tct gcg gaa gag aga aga gaa gag ttg cga caa cca cca gtt aag      414
 Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu Arg Gln Pro Pro Val Lys
                  75                  80                  85

 cgt ttg aga ctt cgt ggt gat tgg tca gat act gga ccc aga gca agg      462
 Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp Thr Gly Pro Arg Ala Arg
              90                  95                 100

 ccg gag agt gaa cga gaa cga gat gga gag cag agt ccc aat gtg tca      510
 Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu Gln Ser Pro Asn Val Ser
         105                 110                 115

 ttg atg cag aga atg tct gat atg tta tca aga tgg ttt gaa gaa gca      558
 Leu Met Gln Arg Met Ser Asp Met Leu Ser Arg Trp Phe Glu Glu Ala
     120                 125                 130

 agt gag gtt gca caa agc aat aga gga cga gga aga tct cga ccc aga      606
 Ser Glu Val Ala Gln Ser Asn Arg Gly Arg Gly Arg Ser Arg Pro Arg
 135                 140                 145                 150

 ggt gga aca agt caa tca gat att tca act ctt cct acg gtc cca tca      654
 Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr Leu Pro Thr Val Pro Ser
                 155                 160                 165

 agt cct gat ttg gaa gtg agt gaa act gca atg gaa gta gat act cca      702
 Ser Pro Asp Leu Glu Val Ser Glu Thr Ala Met Glu Val Asp Thr Pro
             170                 175                 180

 gct gaa caa ttt ctt cag cct tct aca tcc tct aca atg tca gct cag      750
 Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr Met Ser Ala Gln
         185                 190                 195

 gct cat tcg aca tca tct ccc aca gaa agc cct cat tct act cct ttg      798
 Ala His Ser Thr Ser Ser Pro Thr Glu Ser Pro His Ser Thr Pro Leu
     200                 205                 210

 cta tct tct cca gat agt gaa caa agg cag tct gtt gag gca tct gga      846
 Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln Ser Val Glu Ala Ser Gly
 215                 220                 225                 230

 cac cac aca cat cat cag tct gat tct cct tct tct gtg gtt aac aaa      894
 His His Thr His His Gln Ser Asp Ser Pro Ser Ser Val Val Asn Lys
                 235                 240                 245

 cag ctc gga tcc atg tca ctt gac gag caa cag gat aac aat aat gaa      942
 Gln Leu Gly Ser Met Ser Leu Asp Glu Gln Gln Asp Asn Asn Asn Glu
             250                 255                 260

 aag ctg agc ccc aaa cca ggg aca ggt gaa cca gtt tta agt ttg cac      990
 Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val Leu Ser Leu His
         265                 270                 275

 tac agc aca gaa gga aca act aca agc aca ata aaa ctg aac ttt aca     1038
 Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu Asn Phe Thr
     280                 285                 290

 gat gaa tgg agc agt ata gca tca agt tct aga gga att ggg agc cat     1086
 Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile Gly Ser His
 295                 300                 305                 310

 tgc aaa tct gag ggt cag gag gaa tct ttc gtc cca cag agc tca gtg     1134
 Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro Gln Ser Ser Val
                 315                 320                 325

 caa cca cca gaa gga gac agt gaa aca aaa gct cct gaa gaa tca tca     1182
 Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu Glu Ser Ser
             330                 335                 340

 gag gat gtg aca aaa tat cag gaa gga gta tct gca gaa aac cca gtt     1230
 Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu Asn Pro Val
         345                 350                 355

 gag aac cat atc aat ata aca caa tca gat aag ttc aca gcc aag cca     1278
 Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr Ala Lys Pro
     360                 365                 370

 ttg gat tcc aac tca gga gaa aga aat gac ctc aat ctt gat cgc tct     1326
 Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu Asp Arg Ser
 375                 380                 385                 390

 tgt ggg gtt cca gaa gaa tct gct tca tct gaa aaa gcc aag gaa cca     1374
 Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala Lys Glu Pro
                 395                 400                 405

 gaa act tca gat cag act agc act gag agt gct acc aat gaa aat aac     1422
 Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn Glu Asn Asn
             410                 415                 420

 acc aat cct gag cct cag ttc caa aca gaa gcc act ggg cct tca gct     1470
 Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly Pro Ser Ala
         425                 430                 435

 cat gaa gaa aca tcc acc agg gac tct gct ctt cag gac aca gat gac     1518
 His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp Thr Asp Asp
     440                 445                 450

 agt gat gat gac cca gtc ctg atc cca ggt gca agg tat cga gca gga     1566
 Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr Arg Ala Gly
 455                 460                 465                 470

 cct ggt gat aga cgc tct gct gtt gcc cgt att cag gag ttc ttc aga     1614
 Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln Glu Phe Phe Arg
                 475                 480                 485

 cgg aga aaa gaa agg aaa gaa atg gaa gaa ttg gat act ttg aac att     1662
 Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp Thr Leu Asn Ile
             490                 495                 500

 aga agg ccg cta gta aaa atg gtt tat aaa ggc cat cgc aac tcc agg     1710
 Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His Arg Asn Ser Arg
         505                 510                 515

 aca atg ata aaa gaa gcc aat ttc tgg ggt gct aac ttt gta atg agt     1758
 Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn Phe Val Met Ser
     520                 525                 530

 ggt tct gac tgt ggc cac att ttc atc tgg gat cgg cac act gct gag     1806
 Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg His Thr Ala Glu
 535                 540                 545                 550

 cat ttg atg ctt ctg gaa gct gat aat cat gtg gta aac tgc ctg cag     1854
 His Leu Met Leu Leu Glu Ala Asp Asn His Val Val Asn Cys Leu Gln
                 555                 560                 565

 cca cat ccg ttt gac cca att tta gcc tca tct ggc ata gat tat gac     1902
 Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly Ile Asp Tyr Asp
             570                 575                 580

 ata aag atc tgg tca cca tta gaa gag tca agg att ttt aac cga aaa     1950
 Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile Phe Asn Arg Lys
         585                 590                 595

 ctt gct gat gaa gtt ata act cga aac gaa ctc atg ctg gaa gaa act     1998
 Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met Leu Glu Glu Thr
     600                 605                 610

 aga aac acc att aca gtt cca gcc tct ttc atg ttg agg atg ttg gct     2046
 Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu Arg Met Leu Ala
 615                 620                 625                 630

 tca ctt aat cat atc cga gct gac cgg ttg gag ggt gac aga tca gaa     2094
 Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly Asp Arg Ser Glu
                 635                 640                 645

 ggc tct ggt caa gag aat gaa aat gag gat gag gaa taa taaactcttt      2143
 Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu 
             650                 655

 ttggcaagca cttaaatgtt ctgaaatttg tataagacat ttattatatt tttttcttta   2203

 cagagcttta gtgcaatttt aaggttatgg tttttggagt ttttcccttt ttttgggata   2263

 acctaacatt ggtttggaat gattgtgtgc atgaatttgg gagattgtat aaaacaaaac   2323

 tagcagaatg tttttaaaac tttttgccgt gtatgaggag tgctagaaaa tgcaaagtgc   2383

 aatattttcc ctaaccttca aatgtgggag cttggatcaa tgttgaagaa taattttcat   2443

 catagtgaaa atgttggttc aaataaattt ctacacttgc catttgcatg tttgttgctt   2503

 tctaattaaa gaaactggtt gttttaaaaa aaaaaaaa                           2541




      <210> 21
      <211> 2448
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(2040)

      <400> 21
 tgtaaagatg atattttaat taactgtcga cgggctgcca cgtctgttgc tatttgccca     60

 ccaataccat attaccttgc tgttggttgt tctgacagct cagtacgaat atatgatcgg    120

 cga  atg ctg ggc aca aga gct aca ggg aat tat gca ggt cga ggg act     168
      Met Leu Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr
        1               5                  10                  15

 act gga atg gtt gcc cgt ttt att cct tcc cat ctt aat aat aag tcc      216
 Thr Gly Met Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser
                  20                  25                  30

 tgc aga gtg aca tct ctg tgt tac agt gaa gat ggt caa gag att ctc      264
 Cys Arg Val Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu
              35                  40                  45

 gtt agt tac tct tca gat tac ata tat ctt ttt gac ccg aaa gat gat      312
 Val Ser Tyr Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp
          50                  55                  60

 aca gca cga gaa ctt aaa act cct tct gcg gaa gag aga aga gaa gag      360
 Thr Ala Arg Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu
      65                  70                  75

 ttg cga caa cca cca gtt aag cgt ttg aga ctt cgt ggt gat tgg tca      408
 Leu Arg Gln Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser
  80                  85                  90                  95

 gat act gga ccc aga gca agg ccg gag agt gaa cga gaa cga gat gga      456
 Asp Thr Gly Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly
                 100                 105                 110

 gag cag agt ccc aat gtg tca ttg atg cag aga atg tct gat atg tta      504
 Glu Gln Ser Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu
             115                 120                 125

 tca aga tgg ttt gaa gaa gca agt gag gtt gca caa agc aat aga gga      552
 Ser Arg Trp Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly
         130                 135                 140

 cga gga aga tct cga ccc aga ggt gga aca agt caa tca gat att tca      600
 Arg Gly Arg Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser
     145                 150                 155

 act ctt cct acg gtc cca tca agt cct gat ttg gaa gtg agt gaa act      648
 Thr Leu Pro Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr
 160                 165                 170                 175

 gca atg gaa gta gat act cca gct gaa caa ttt ctt cag cct tct aca      696
 Ala Met Glu Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr
                 180                 185                 190

 tcc tct aca atg tca gct cag gct cat tcg aca tca tct ccc aca gaa      744
 Ser Ser Thr Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu
             195                 200                 205

 agc cct cat tct act cct ttg cta tct tct cca gat agt gaa caa agg      792
 Ser Pro His Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg
         210                 215                 220

 cag tct gtt gag gca tct gga cac cac aca cat cat cag tct gat aac      840
 Gln Ser Val Glu Ala Ser Gly His His Thr His His Gln Ser Asp Asn
     225                 230                 235

 aat aat gaa aag ctg agc ccc aaa cca ggg aca ggt gaa cca gtt tta      888
 Asn Asn Glu Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val Leu
 240                 245                 250                 255

 agt ttg cac tac agc aca gaa gga aca act aca agc aca ata aaa ctg      936
 Ser Leu His Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu
                 260                 265                 270

 aac ttt aca gat gaa tgg agc agt ata gca tca agt tct aga gga att      984
 Asn Phe Thr Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile
             275                 280                 285

 ggg agc cat tgc aaa tct gag ggt cag gag gaa tct ttc gtc cca cag     1032
 Gly Ser His Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro Gln
         290                 295                 300

 agc tca gtg caa cca cca gaa gga gac agt gaa aca aaa gct cct gaa     1080
 Ser Ser Val Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu
     305                 310                 315

 gaa tca tca gag gat gtg aca aaa tat cag gaa gga gta tct gca gaa     1128
 Glu Ser Ser Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu
 320                 325                 330                 335

 aac cca gtt gag aac cat atc aat ata aca caa tca gat aag ttc aca     1176
 Asn Pro Val Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr
                 340                 345                 350

 gcc aag cca ttg gat tcc aac tca gga gaa aga aat gac ctc aat ctt     1224
 Ala Lys Pro Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu
             355                 360                 365

 gat cgc tct tgt ggg gtt cca gaa gaa tct gct tca tct gaa aaa gcc     1272
 Asp Arg Ser Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala
         370                 375                 380

 aag gaa cca gaa act tca gat cag act agc act gag agt gct acc aat     1320
 Lys Glu Pro Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn
     385                 390                 395

 gaa aat aac acc aat cct gag cct cag ttc caa aca gaa gcc act ggg     1368
 Glu Asn Asn Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly
 400                 405                 410                 415

 cct tca gct cat gaa gaa aca tcc acc agg gac tct gct ctt cag gac     1416
 Pro Ser Ala His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp
                 420                 425                 430

 aca gat gac agt gat gat gac cca gtc ctg atc cca ggt gca agg tat     1464
 Thr Asp Asp Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr
             435                 440                 445

 cga gca gga cct ggt gat aga cgc tct gct gtt gcc cgt att cag gag     1512
 Arg Ala Gly Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln Glu
         450                 455                 460

 ttc ttc aga cgg aga aaa gaa agg aaa gaa atg gaa gaa ttg gat act     1560
 Phe Phe Arg Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp Thr
     465                 470                 475

 ttg aac att aga agg ccg cta gta aaa atg gtt tat aaa ggc cat cgc     1608
 Leu Asn Ile Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His Arg
 480                 485                 490                 495

 aac tcc agg aca atg ata aaa gaa gcc aat ttc tgg ggt gct aac ttt     1656
 Asn Ser Arg Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn Phe
                 500                 505                 510

 gta atg agt ggt tct gac tgt ggc cac att ttc atc tgg gat cgg cac     1704
 Val Met Ser Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg His
             515                 520                 525

 act gct gag cat ttg atg ctt ctg gaa gct gat aat cat gtg gta aac     1752
 Thr Ala Glu His Leu Met Leu Leu Glu Ala Asp Asn His Val Val Asn
         530                 535                 540

 tgc ctg cag cca cat ccg ttt gac cca att tta gcc tca tct ggc ata     1800
 Cys Leu Gln Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly Ile
     545                 550                 555

 gat tat gac ata aag atc tgg tca cca tta gaa gag tca agg att ttt     1848
 Asp Tyr Asp Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile Phe
 560                 565                 570                 575

 aac cga aaa ctt gct gat gaa gtt ata act cga aac gaa ctc atg ctg     1896
 Asn Arg Lys Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met Leu
                 580                 585                 590

 gaa gaa act aga aac acc att aca gtt cca gcc tct ttc atg ttg agg     1944
 Glu Glu Thr Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu Arg
             595                 600                 605

 atg ttg gct tca ctt aat cat atc cga gct gac cgg ttg gag ggt gac     1992
 Met Leu Ala Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly Asp
         610                 615                 620

 aga tca gaa ggc tct ggt caa gag aat gaa aat gag gat gag gaa taa     2040
 Arg Ser Glu Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu 
     625                 630                 635

 taaactcttt ttggcaagca cttaaatgtt ctgaaatttg tataagacat ttattatatt   2100

 tttttcttta cagagcttta gtgcaatttt aaggttatgg tttttggagt ttttcccttt   2160

 ttttgggata acctaacatt ggtttggaat gattgtgtgc atgaatttgg gagattgtat   2220

 aaaacaaaac tagcagaatg tttttaaaac tttttgccgt gtatgaggag tgctagaaaa   2280

 tgcaaagtgc aatattttcc ctaaccttca aatgtgggag cttggatcaa tgttgaagaa   2340

 taattttcat catagtgaaa atgttggttc aaataaattt ctacacttgc catttgcatg   2400

 tttgttgctt tctaattaaa gaaactggtt gttttaaaaa aaaaaaaa                2448




      <210> 22
      <211> 1648
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(1605)

      <400> 22
 catctgcttg gctcttagca tgtggttggg acaagctttc tgtgcctggc taagttttat     60

 gaacagatgg cacagcaaat tcctgatggt taggtcaaga ggagaatgtg gtgcccaccg    120

 ccaacttctg tgtgtgtttg ttttcagaga ctccctacgg gaggggatgc cccgcaggaa    180

 catggagcgg cattgccccc gaatgtccag attatccctg tttttgtgac caaagaggaa    240

 gccattagtc tccacgagtt cccggtggaa cag atg aca agg tct cta gca tct     294
                                      Met Thr Arg Ser Leu Ala Ser
                                        1               5

 cca gca gga ctc cag gat ggt tca gcc cag cac cac cca aag ggt ggg      342
 Pro Ala Gly Leu Gln Asp Gly Ser Ala Gln His His Pro Lys Gly Gly
          10                  15                  20

 agc aca tct gcc ctg aaa gaa aac gcc act ggc cat gtg gaa tcc atg      390
 Ser Thr Ser Ala Leu Lys Glu Asn Ala Thr Gly His Val Glu Ser Met
      25                  30                  35

 gcc tgg acc acc cca gat ccc aca tcc cct gac gaa gct tgt cca gat      438
 Ala Trp Thr Thr Pro Asp Pro Thr Ser Pro Asp Glu Ala Cys Pro Asp
  40                  45                  50                  55

 ggc agg aag gag aac gga tgc ttg tct ggc cat gat ctg gag agc atc      486
 Gly Arg Lys Glu Asn Gly Cys Leu Ser Gly His Asp Leu Glu Ser Ile
                  60                  65                  70

 agg ccc gca gga ctg cac aac tct gcc agg ggg gag gtt ctt ggc ctc      534
 Arg Pro Ala Gly Leu His Asn Ser Ala Arg Gly Glu Val Leu Gly Leu
              75                  80                  85

 agc tcc tcc ctg ggg aag gaa cta gtc ttt ctc caa gaa gaa ctc gac      582
 Ser Ser Ser Leu Gly Lys Glu Leu Val Phe Leu Gln Glu Glu Leu Asp
          90                  95                 100

 ttg tct gaa atc cac att cca gag gct cag gaa gtg gaa atg gcc tca      630
 Leu Ser Glu Ile His Ile Pro Glu Ala Gln Glu Val Glu Met Ala Ser
     105                 110                 115

 ggt cat ttt gcc ttc cta cat gtg cct gtt cca gat ggc agg gct cct      678
 Gly His Phe Ala Phe Leu His Val Pro Val Pro Asp Gly Arg Ala Pro
 120                 125                 130                 135

 tac tgc aag gca tct ctc agc gcc tcc agc agc ctg gaa ccc acg cct      726
 Tyr Cys Lys Ala Ser Leu Ser Ala Ser Ser Ser Leu Glu Pro Thr Pro
                 140                 145                 150

 cct gag gac aca gcc atc agc agc ttg cgc cct ccc tct gct cct gag      774
 Pro Glu Asp Thr Ala Ile Ser Ser Leu Arg Pro Pro Ser Ala Pro Glu
             155                 160                 165

 atg ctg acc cag cat gga gcc caa gag cag ctc gaa gac cat cct ggc      822
 Met Leu Thr Gln His Gly Ala Gln Glu Gln Leu Glu Asp His Pro Gly
         170                 175                 180

 cat agc agc caa gcc ccc att ccc aga gca gac cct ctc ccc aga agg      870
 His Ser Ser Gln Ala Pro Ile Pro Arg Ala Asp Pro Leu Pro Arg Arg
     185                 190                 195

 acc cgc agg ccc ttg tta ttg cct cgc tta gat cca gga cag aga gga      918
 Thr Arg Arg Pro Leu Leu Leu Pro Arg Leu Asp Pro Gly Gln Arg Gly
 200                 205                 210                 215

 aac aag ctt ccc acg ggg gaa caa ggc ctg gat gag gat gtt gat ggg      966
 Asn Lys Leu Pro Thr Gly Glu Gln Gly Leu Asp Glu Asp Val Asp Gly
                 220                 225                 230

 gtc tgt gaa agc cac gca gcc cct ggt ctg gaa tgc agt tca ggc tca     1014
 Val Cys Glu Ser His Ala Ala Pro Gly Leu Glu Cys Ser Ser Gly Ser
             235                 240                 245

 gca aac tgt cag ggt gct ggc ccc tct gca gat gga atc agc tcc agg     1062
 Ala Asn Cys Gln Gly Ala Gly Pro Ser Ala Asp Gly Ile Ser Ser Arg
         250                 255                 260

 ctg aca cca gca gag tcc tgc atg ggg ctc gtg agg atg aat ctc tac     1110
 Leu Thr Pro Ala Glu Ser Cys Met Gly Leu Val Arg Met Asn Leu Tyr
     265                 270                 275

 act cac tgc gtc aaa ggg ctg atg ctg tcc ctg ctg gct gag gag ccg     1158
 Thr His Cys Val Lys Gly Leu Met Leu Ser Leu Leu Ala Glu Glu Pro
 280                 285                 290                 295

 ctg ctg gga gac agc gca gcc ata gag gaa gtg tac cac agc agc ctg     1206
 Leu Leu Gly Asp Ser Ala Ala Ile Glu Glu Val Tyr His Ser Ser Leu
                 300                 305                 310

 gct tca ctg aat ggg ctg gaa gtc cac ctg aaa gag acg ctg ccc agg     1254
 Ala Ser Leu Asn Gly Leu Glu Val His Leu Lys Glu Thr Leu Pro Arg
             315                 320                 325

 gat gag gca gcc tcc acg agc agc acc tac aac ttc aca tat tac gac     1302
 Asp Glu Ala Ala Ser Thr Ser Ser Thr Tyr Asn Phe Thr Tyr Tyr Asp
         330                 335                 340

 cgc att cag agc ttg ctg atg gca aac ctg ccg cag gtg gcc acc ccg     1350
 Arg Ile Gln Ser Leu Leu Met Ala Asn Leu Pro Gln Val Ala Thr Pro
     345                 350                 355

 cat gat cgc cgc ttc ctc cag gcc gtc agc ctg atg cat agc gaa ttt     1398
 His Asp Arg Arg Phe Leu Gln Ala Val Ser Leu Met His Ser Glu Phe
 360                 365                 370                 375

 gcc cag ctg ccc gcg ctt tat gaa atg act gtc aga aat gcc tcc acg     1446
 Ala Gln Leu Pro Ala Leu Tyr Glu Met Thr Val Arg Asn Ala Ser Thr
                 380                 385                 390

 gct gtg tac gcc tgt tgc aac ccc atc cag gag aca tat ttc cag cag     1494
 Ala Val Tyr Ala Cys Cys Asn Pro Ile Gln Glu Thr Tyr Phe Gln Gln
             395                 400                 405

 ctg gca cct gca gca cgg agc tcc ggc ttc cca aac cct cag gat ggc     1542
 Leu Ala Pro Ala Ala Arg Ser Ser Gly Phe Pro Asn Pro Gln Asp Gly
         410                 415                 420

 gcc ttc agc ctc tcc ggc aaa gca aag cag aag ctg ctg aag cac ggg     1590
 Ala Phe Ser Leu Ser Gly Lys Ala Lys Gln Lys Leu Leu Lys His Gly
     425                 430                 435

 gtg aac ttg ctc tga actgcaccca ggaggtgact gggaaggaga aaaccagcaa     1645
 Val Asn Leu Leu 
 440

 agg                                                                 1648




      <210> 23
      <211> 1923
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(1844)

      <400> 23
 gtcaggatcg cagaaagtat gtcccttctc tcacc   atg agc tgg ctc tcc agt      53
                                          Met Ser Trp Leu Ser Ser
                                            1               5

 tcc cag gga gtg gta cta aca gcc tac cac ccc agc ggc aag gac cag      101
 Ser Gln Gly Val Val Leu Thr Ala Tyr His Pro Ser Gly Lys Asp Gln
              10                  15                  20

 gcc gtc ggg aac agc cat gca aag gca ggg gag gaa gcc acc tcg agt      149
 Ala Val Gly Asn Ser His Ala Lys Ala Gly Glu Glu Ala Thr Ser Ser
          25                  30                  35

 cgc aga tat ggc cag tac act atg aac cag gaa agc acc acc atc aaa      197
 Arg Arg Tyr Gly Gln Tyr Thr Met Asn Gln Glu Ser Thr Thr Ile Lys
      40                  45                  50

 gtt atg gag aag cct cca ttt gat cga tca att tcc cag gat tct ttg      245
 Val Met Glu Lys Pro Pro Phe Asp Arg Ser Ile Ser Gln Asp Ser Leu
  55                  60                  65                  70

 gat gaa cta tct atg gaa gac tat tgg ata gaa cta gaa aac atc aag      293
 Asp Glu Leu Ser Met Glu Asp Tyr Trp Ile Glu Leu Glu Asn Ile Lys
                  75                  80                  85

 aaa tct agt gaa aac agc caa gaa gat caa gag gtg gtt gtt gtc aaa      341
 Lys Ser Ser Glu Asn Ser Gln Glu Asp Gln Glu Val Val Val Val Lys
              90                  95                 100

 gag cct gat gag gga gaa ttg gaa gaa gag tgg ctt aaa gag gcc ggt      389
 Glu Pro Asp Glu Gly Glu Leu Glu Glu Glu Trp Leu Lys Glu Ala Gly
         105                 110                 115

 tta tcc aat ctc ttc gga gag tct gct gga gat cca cag gaa agc att      437
 Leu Ser Asn Leu Phe Gly Glu Ser Ala Gly Asp Pro Gln Glu Ser Ile
     120                 125                 130

 gtg ttt tta tca aca ttg acg cgg acc cag gca gca gca gtt cag aag      485
 Val Phe Leu Ser Thr Leu Thr Arg Thr Gln Ala Ala Ala Val Gln Lys
 135                 140                 145                 150

 cga gta gag acg gtc tcc cag acc ttg agg aaa aaa aac aaa cag tac      533
 Arg Val Glu Thr Val Ser Gln Thr Leu Arg Lys Lys Asn Lys Gln Tyr
                 155                 160                 165

 cag att cct gac gtc aga gac ata ttt gct caa cag aga gaa tca aaa      581
 Gln Ile Pro Asp Val Arg Asp Ile Phe Ala Gln Gln Arg Glu Ser Lys
             170                 175                 180

 gaa aca gct cca ggt ggc act gaa tcg cag tca ctt aga aca aat gaa      629
 Glu Thr Ala Pro Gly Gly Thr Glu Ser Gln Ser Leu Arg Thr Asn Glu
         185                 190                 195

 aac aaa tac caa gga aga gat gac gag gca tct aac ctt gtt ggt gaa      677
 Asn Lys Tyr Gln Gly Arg Asp Asp Glu Ala Ser Asn Leu Val Gly Glu
     200                 205                 210

 gag aag ctg atc cca cct gag gag acg cct gcc cct gaa aca gac atc      725
 Glu Lys Leu Ile Pro Pro Glu Glu Thr Pro Ala Pro Glu Thr Asp Ile
 215                 220                 225                 230

 aac ctg gag gta tca ttt gcc gag caa gca ctc aat cag aaa gag agc      773
 Asn Leu Glu Val Ser Phe Ala Glu Gln Ala Leu Asn Gln Lys Glu Ser
                 235                 240                 245

 tcc aag gag aaa atc cag aag agc aaa ggc gat gat gcc aca tta cct      821
 Ser Lys Glu Lys Ile Gln Lys Ser Lys Gly Asp Asp Ala Thr Leu Pro
             250                 255                 260

 agt ttc aga ttg cca aaa gac aaa acg ggt acc aca agg att ggt gac      869
 Ser Phe Arg Leu Pro Lys Asp Lys Thr Gly Thr Thr Arg Ile Gly Asp
         265                 270                 275

 ctc gca ccc cag gac atg aag aaa gtt tgc cat tta gcc cta att gag      917
 Leu Ala Pro Gln Asp Met Lys Lys Val Cys His Leu Ala Leu Ile Glu
     280                 285                 290

 ctg act gcc ctc tat gat gta ttg ggt att gag ctg aaa caa caa aaa      965
 Leu Thr Ala Leu Tyr Asp Val Leu Gly Ile Glu Leu Lys Gln Gln Lys
 295                 300                 305                 310

 gct gtg aaa atc aaa aca aaa gat tct ggt ctt ttt tgc gtt cca ttg     1013
 Ala Val Lys Ile Lys Thr Lys Asp Ser Gly Leu Phe Cys Val Pro Leu
                 315                 320                 325

 aca gcg cta tta gaa caa gat cag agg aaa gta cca gga atg cga ata     1061
 Thr Ala Leu Leu Glu Gln Asp Gln Arg Lys Val Pro Gly Met Arg Ile
             330                 335                 340

 ccc ttg atc ttt caa aaa ctg att tct cga att gaa gag aga ggt ttg     1109
 Pro Leu Ile Phe Gln Lys Leu Ile Ser Arg Ile Glu Glu Arg Gly Leu
         345                 350                 355

 gaa aca gaa ggc ctc tta cgg atc cct gga gct gcc att aga atc aag     1157
 Glu Thr Glu Gly Leu Leu Arg Ile Pro Gly Ala Ala Ile Arg Ile Lys
     360                 365                 370

 aat ctt tgc caa gaa cta gaa gca aag ttt tat gaa ggg act ttt aat     1205
 Asn Leu Cys Gln Glu Leu Glu Ala Lys Phe Tyr Glu Gly Thr Phe Asn
 375                 380                 385                 390

 tgg gaa agt gtc aaa cag cat gat gcc gcc agc ctg ctg aag ctc ttc     1253
 Trp Glu Ser Val Lys Gln His Asp Ala Ala Ser Leu Leu Lys Leu Phe
                 395                 400                 405

 att cgg gag ttg ccc cag cca ctg ctc agt gtg gag tat ctc aaa gcc     1301
 Ile Arg Glu Leu Pro Gln Pro Leu Leu Ser Val Glu Tyr Leu Lys Ala
             410                 415                 420

 ttt cag gct gtc cag aat ctt cca acc aag aag cag caa cta cag gct     1349
 Phe Gln Ala Val Gln Asn Leu Pro Thr Lys Lys Gln Gln Leu Gln Ala
         425                 430                 435

 ttg aac ctt ctt gtc atc ctc cta cct gat gca aac agg gac aca ctg     1397
 Leu Asn Leu Leu Val Ile Leu Leu Pro Asp Ala Asn Arg Asp Thr Leu
     440                 445                 450

 aag gcc ctt ctt gaa ttt ctc caa aga gta ata gat aat aaa gaa aaa     1445
 Lys Ala Leu Leu Glu Phe Leu Gln Arg Val Ile Asp Asn Lys Glu Lys
 455                 460                 465                 470

 aat aaa atg aca gtc atg aat gta gca atg gtc atg gcc ccg aat ctc     1493
 Asn Lys Met Thr Val Met Asn Val Ala Met Val Met Ala Pro Asn Leu
                 475                 480                 485

 ttt atg tgt cat gca ttg gga ttg aag tcc agt gaa cag cga gaa ttt     1541
 Phe Met Cys His Ala Leu Gly Leu Lys Ser Ser Glu Gln Arg Glu Phe
             490                 495                 500

 gta atg gca gct ggg aca gca aat acc atg cac tta ttg att aag tac     1589
 Val Met Ala Ala Gly Thr Ala Asn Thr Met His Leu Leu Ile Lys Tyr
         505                 510                 515

 caa aaa ctt ctg tgg aca att ccc aag ttt att gta aac caa gtg agg     1637
 Gln Lys Leu Leu Trp Thr Ile Pro Lys Phe Ile Val Asn Gln Val Arg
     520                 525                 530

 aag caa aac acg gaa aat cat aaa aag gat aaa aga gcc atg aag aaa     1685
 Lys Gln Asn Thr Glu Asn His Lys Lys Asp Lys Arg Ala Met Lys Lys
 535                 540                 545                 550

 ttg ctg aag aaa atg gct tat gac cga gaa aaa tat gaa aag caa gat     1733
 Leu Leu Lys Lys Met Ala Tyr Asp Arg Glu Lys Tyr Glu Lys Gln Asp
                 555                 560                 565

 aag agt aca aat gat gct gac gtt cct cag gga gtg att cga gtg caa     1781
 Lys Ser Thr Asn Asp Ala Asp Val Pro Gln Gly Val Ile Arg Val Gln
             570                 575                 580

 gct ccc cat ctt tcg aaa gtt tcc atg gca ata cag cta act gaa gga     1829
 Ala Pro His Leu Ser Lys Val Ser Met Ala Ile Gln Leu Thr Glu Gly
         585                 590                 595

 act aaa agc cag tga tgttactttg ccaggtttct tcaggcccaa ggaaagtggg     1884
 Thr Lys Ser Gln 
     600

 ggtttgccca gactctcaag aaaggagaag tttttttgg                          1923




      <210> 24
      <211> 601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(558)

      <400> 24
 cagaatggga agaggactta gtgagaattc cctgaacaca ggagaaaacc gaagcccaga     60

 gagtgg   atg gcc aag tcc aag gtc aca cag cca agt gca tcc gag cag     108
          Met Ala Lys Ser Lys Val Thr Gln Pro Ser Ala Ser Glu Gln
            1               5                  10

 cgc agg atc cag gtt tcc tgc ccc agt gct ctt tct gca gcc cat gcc      156
 Arg Arg Ile Gln Val Ser Cys Pro Ser Ala Leu Ser Ala Ala His Ala
  15                  20                  25                  30

 acc tgt ttt cat gct atc tca gtt cac ctt cca gct aca cac ctg caa      204
 Thr Cys Phe His Ala Ile Ser Val His Leu Pro Ala Thr His Leu Gln
                  35                  40                  45

 tca gaa aca gaa agt ctg aga gtg tgt gtg gag cca aag agg gga cag      252
 Ser Glu Thr Glu Ser Leu Arg Val Cys Val Glu Pro Lys Arg Gly Gln
              50                  55                  60

 cag tgg tta gaa gca agg cac aag tca tac cta cat tca agg aga ggg      300
 Gln Trp Leu Glu Ala Arg His Lys Ser Tyr Leu His Ser Arg Arg Gly
          65                  70                  75

 gac cat gca aag gat aaa ctg cag aga gac aac aga ttt gca tcc cag      348
 Asp His Ala Lys Asp Lys Leu Gln Arg Asp Asn Arg Phe Ala Ser Gln
      80                  85                  90

 aca cat tca cac tgg gcc aag agc agc tgc cat tgc aga ttc gag tca      396
 Thr His Ser His Trp Ala Lys Ser Ser Cys His Cys Arg Phe Glu Ser
  95                 100                 105                 110

 cgt cct ttt ttc ctt cct tct cct tct tgg agt tac aac aga agc tgg      444
 Arg Pro Phe Phe Leu Pro Ser Pro Ser Trp Ser Tyr Asn Arg Ser Trp
                 115                 120                 125

 gga ggt gag agt gca gaa agg acg tgg atg aag cag aga ggc acg tgc      492
 Gly Gly Glu Ser Ala Glu Arg Thr Trp Met Lys Gln Arg Gly Thr Cys
             130                 135                 140

 ctg tct cat tcg cct ctg gat ctg ctg cat cca gga ctg tgc cag cac      540
 Leu Ser His Ser Pro Leu Asp Leu Leu His Pro Gly Leu Cys Gln His
         145                 150                 155

 aaa gtg gga gcc cga taa atattt attgaagaaa tgaaaggtga caaaaggcag      594
 Lys Val Gly Ala Arg 
     160

 aaggagg                                                              601




      <210> 25
      <211> 2308
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(1969)

      <400> 25
 cttcggggaa ctgatcacag ccgcacatga gcttggagtt gcccatcctc ctggctatcc     60

 tttgttcacg ctagtggcta aactggcaat tacactgttt ccttttggtt caattgccta    120

 ccgcgtcaat cttctctgtg gcttatttgg agcagtagct gcatcattac tttttttcac    180

 cgttttcagg ctttctggct catctgctgg aggaatcctt gctgcggggg tgttttcatt    240

 ttctcgtcta acatggcagt ggtccattgc agcagaggtt tttagcttaa acaatctctt    300

 tgtggggctg ctt   atg gct ctt act gta cat ttt gag gaa gca gca act     349
                  Met Ala Leu Thr Val His Phe Glu Glu Ala Ala Thr
                    1               5                  10

 gct aag gag aga tca aag gta gct aaa att ggt gct ttc tgc tgt ggc      397
 Ala Lys Glu Arg Ser Lys Val Ala Lys Ile Gly Ala Phe Cys Cys Gly
          15                  20                  25

 ctt agt tta tgt aac cag cac aca ata ata ctc tat gtt ttg tgc ata      445
 Leu Ser Leu Cys Asn Gln His Thr Ile Ile Leu Tyr Val Leu Cys Ile
      30                  35                  40

 ata cct tgg att ctc ttt caa ctt tta aaa aag aag gaa ctc tcc ctg      493
 Ile Pro Trp Ile Leu Phe Gln Leu Leu Lys Lys Lys Glu Leu Ser Leu
  45                  50                  55                  60

 ggc tct ttg ttg aag ttg agc ctg tac ttc tct gct ggt ttg ctg ccc      541
 Gly Ser Leu Leu Lys Leu Ser Leu Tyr Phe Ser Ala Gly Leu Leu Pro
                  65                  70                  75

 tat gtc cac ctt ccc atc tca tct tac ctt aat cac gcc cgg tgg acc      589
 Tyr Val His Leu Pro Ile Ser Ser Tyr Leu Asn His Ala Arg Trp Thr
              80                  85                  90

 tgg gga gac cag aca aca ctg caa gga ttt ttg aca cat ttt ctc agg      637
 Trp Gly Asp Gln Thr Thr Leu Gln Gly Phe Leu Thr His Phe Leu Arg
          95                 100                 105

 gaa gaa tat gga acc ttc agc ctg gcc aaa tct gaa ata gga tcc agt      685
 Glu Glu Tyr Gly Thr Phe Ser Leu Ala Lys Ser Glu Ile Gly Ser Ser
     110                 115                 120

 atg tct gaa ata ctg ctt tct caa gta aca aat atg agg acc gaa ctc      733
 Met Ser Glu Ile Leu Leu Ser Gln Val Thr Asn Met Arg Thr Glu Leu
 125                 130                 135                 140

 tca ttc aac atc caa gcc ctt gca gtt tgt gca aat ata tgt tta gca      781
 Ser Phe Asn Ile Gln Ala Leu Ala Val Cys Ala Asn Ile Cys Leu Ala
                 145                 150                 155

 aca aag gac aga cag aat cca tca tta gta tgg ctt ttt act gga atg      829
 Thr Lys Asp Arg Gln Asn Pro Ser Leu Val Trp Leu Phe Thr Gly Met
             160                 165                 170

 ttt tgc att tat tca ttg ttc ttt gct tgg aga gca aat tta gat att      877
 Phe Cys Ile Tyr Ser Leu Phe Phe Ala Trp Arg Ala Asn Leu Asp Ile
         175                 180                 185

 tca aaa cca ctt ttc atg ggt gtg gtg gaa cga ttc tgg atg cag agc      925
 Ser Lys Pro Leu Phe Met Gly Val Val Glu Arg Phe Trp Met Gln Ser
     190                 195                 200

 aat gca gta gtg gcc gtc ctc gct ggc att ggt ttg gct gca gtt gtg      973
 Asn Ala Val Val Ala Val Leu Ala Gly Ile Gly Leu Ala Ala Val Val
 205                 210                 215                 220

 tct gag act aac cga gtg ctg aat agc aat ggg ctt cag tgt ctg gaa     1021
 Ser Glu Thr Asn Arg Val Leu Asn Ser Asn Gly Leu Gln Cys Leu Glu
                 225                 230                 235

 tgg ctt tct gca act ctt ttt gta gtt tac caa ata tat tct aat tac     1069
 Trp Leu Ser Ala Thr Leu Phe Val Val Tyr Gln Ile Tyr Ser Asn Tyr
             240                 245                 250

 agt gtt tgt gac caa agg acc aac tat gtg att gat aag ttc gca aag     1117
 Ser Val Cys Asp Gln Arg Thr Asn Tyr Val Ile Asp Lys Phe Ala Lys
         255                 260                 265

 aac ctt ctc acc tct atg cct cat gat gca att atc tta ctc aga gga     1165
 Asn Leu Leu Thr Ser Met Pro His Asp Ala Ile Ile Leu Leu Arg Gly
     270                 275                 280

 gat ttg cca gga aat tct ctc cgt tac atg cat tac tgt gag ggg ttg     1213
 Asp Leu Pro Gly Asn Ser Leu Arg Tyr Met His Tyr Cys Glu Gly Leu
 285                 290                 295                 300

 agg cct gac att tca tta gtg gat cag gaa atg atg act tac gag tgg     1261
 Arg Pro Asp Ile Ser Leu Val Asp Gln Glu Met Met Thr Tyr Glu Trp
                 305                 310                 315

 tat tta ccc aag atg gca aag cac ttg cca ggt gtc aac ttt cct ggg     1309
 Tyr Leu Pro Lys Met Ala Lys His Leu Pro Gly Val Asn Phe Pro Gly
             320                 325                 330

 aac cgg tgg aat cct gtg gaa gga ata tta cct agt gga atg gtc aca     1357
 Asn Arg Trp Asn Pro Val Glu Gly Ile Leu Pro Ser Gly Met Val Thr
         335                 340                 345

 ttt aat ctt tat cat ttt ctt gaa gta aat aaa caa aaa gaa aca ttt     1405
 Phe Asn Leu Tyr His Phe Leu Glu Val Asn Lys Gln Lys Glu Thr Phe
     350                 355                 360

 gtt tgc ata gga att cat gaa ggc gac cca acc tgg aaa aag aac tat     1453
 Val Cys Ile Gly Ile His Glu Gly Asp Pro Thr Trp Lys Lys Asn Tyr
 365                 370                 375                 380

 tca ctt tgg cca tgg ggg tct tgt gac aaa tta gtt cct ttg gag att     1501
 Ser Leu Trp Pro Trp Gly Ser Cys Asp Lys Leu Val Pro Leu Glu Ile
                 385                 390                 395

 gta ttc aac cct gag gaa tgg att aaa ctt aca aaa aat atc tat aac     1549
 Val Phe Asn Pro Glu Glu Trp Ile Lys Leu Thr Lys Asn Ile Tyr Asn
             400                 405                 410

 tgg acc gaa gaa tat gga agg ttt gat cca tct tct tgg gaa tct gtg     1597
 Trp Thr Glu Glu Tyr Gly Arg Phe Asp Pro Ser Ser Trp Glu Ser Val
         415                 420                 425

 gcc aat gaa gaa atg tgg caa gcg agg atg aaa aca ccg ttc ttc atc     1645
 Ala Asn Glu Glu Met Trp Gln Ala Arg Met Lys Thr Pro Phe Phe Ile
     430                 435                 440

 ttt aac ctg gca gaa act gct cac atg cct tca aaa gtg aaa gct caa     1693
 Phe Asn Leu Ala Glu Thr Ala His Met Pro Ser Lys Val Lys Ala Gln
 445                 450                 455                 460

 ctc tac gct caa gca tat gac ctt tat aag gag att gtc tat tta caa     1741
 Leu Tyr Ala Gln Ala Tyr Asp Leu Tyr Lys Glu Ile Val Tyr Leu Gln
                 465                 470                 475

 aag gag cac cca gtg aat tgg cac aag aac tat gcc atc gcc tgt gag     1789
 Lys Glu His Pro Val Asn Trp His Lys Asn Tyr Ala Ile Ala Cys Glu
             480                 485                 490

 cgg atg ctg cgt ctt cag gca aga gat gca gat cct gaa gtg ctg tta     1837
 Arg Met Leu Arg Leu Gln Ala Arg Asp Ala Asp Pro Glu Val Leu Leu
         495                 500                 505

 tcg gaa acc atc aga cat ttc cgt ctg tac tct cag aaa gca ccg aat     1885
 Ser Glu Thr Ile Arg His Phe Arg Leu Tyr Ser Gln Lys Ala Pro Asn
     510                 515                 520

 gac cca cag caa gct gat att tta ggt gct cta aag cac cta aga aaa     1933
 Asp Pro Gln Gln Ala Asp Ile Leu Gly Ala Leu Lys His Leu Arg Lys
 525                 530                 535                 540

 gaa ctg caa agt ctg aga aat agg aaa aat gtc tga gaca gcaaaatatg     1983
 Glu Leu Gln Ser Leu Arg Asn Arg Lys Asn Val 
                 545                 550

 aaaaacctgc tcatcgttca gcttccaaaa ttctgaagtc tggaagtttt tccttcaaga   2043

 aaagaaactg cataaaaaat ttaaaactaa gtcatctccc agatataagt atcatggtcc   2103

 agcagtactg tttaatgggg tattcagtga ctaaggtctg ctatttatgc aaaattctgt   2163

 ttatcccgtg ttaccaaatt accatttcag tgagaagctt ttgaaaagtc ttctgacttc   2223

 cagtctttca ccagatgact gcactggatt agattctaga agagaatgaa ccattttcat   2283

 ataactaaat attggtcatg aactg                                         2308




      <210> 26
      <211> 3913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(2834)

      <400> 26
 gccctgcgcc agaattcggt tccctcaaaa ttataaaagc aggaaagctc aagacaaaga     60

 aatccaacaa ggctagtgat ttcagtgat  atg gag aat tgg cca aca cca agt     113
                                  Met Glu Asn Trp Pro Thr Pro Ser
                                    1               5

 gaa tta gtg aac act gga ttt cag agc gtc ctc agc caa gga aat aaa      161
 Glu Leu Val Asn Thr Gly Phe Gln Ser Val Leu Ser Gln Gly Asn Lys
      10                  15                  20

 aag cca caa aat aga aaa gaa aaa gaa gag aag gtt gaa aag aga agt      209
 Lys Pro Gln Asn Arg Lys Glu Lys Glu Glu Lys Val Glu Lys Arg Ser
  25                  30                  35                  40

 aac agt gac agc aaa gaa aac cgg gaa aca aaa tta aat ggt cct ggt      257
 Asn Ser Asp Ser Lys Glu Asn Arg Glu Thr Lys Leu Asn Gly Pro Gly
                  45                  50                  55

 gaa aac gtc agt gag gat gag gct cag tca agt aat caa cgt aag aga      305
 Glu Asn Val Ser Glu Asp Glu Ala Gln Ser Ser Asn Gln Arg Lys Arg
              60                  65                  70

 gct aat aag cac aag tgg gta cca ctc cac tta gat gtt gta aga tca      353
 Ala Asn Lys His Lys Trp Val Pro Leu His Leu Asp Val Val Arg Ser
          75                  80                  85

 gag agt caa gaa aga cct gga tcc cgg aac agc tca aga tgt caa cct      401
 Glu Ser Gln Glu Arg Pro Gly Ser Arg Asn Ser Ser Arg Cys Gln Pro
      90                  95                 100

 gaa gca aat aaa cca aca cat aac aat agg aga aat gat aca cga agt      449
 Glu Ala Asn Lys Pro Thr His Asn Asn Arg Arg Asn Asp Thr Arg Ser
 105                 110                 115                 120

 tgg aag cga gat aga gaa aaa aga gat gat caa gat gac gtt tcc agt      497
 Trp Lys Arg Asp Arg Glu Lys Arg Asp Asp Gln Asp Asp Val Ser Ser
                 125                 130                 135

 gtg aga agt gag ggt ggt aat atc cga ggt tcc ttt aga ggt cga gga      545
 Val Arg Ser Glu Gly Gly Asn Ile Arg Gly Ser Phe Arg Gly Arg Gly
             140                 145                 150

 aga ggc cga gga cgg gga aga gga cga ggc aga gga aat cct cga ttg      593
 Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Asn Pro Arg Leu
         155                 160                 165

 aac ttt gat tat tca tat ggt tat caa gaa cat ggt gaa agg act gat      641
 Asn Phe Asp Tyr Ser Tyr Gly Tyr Gln Glu His Gly Glu Arg Thr Asp
     170                 175                 180

 caa cca ttt caa aca gaa ctt aat acc agt atg atg tat tac tat gat      689
 Gln Pro Phe Gln Thr Glu Leu Asn Thr Ser Met Met Tyr Tyr Tyr Asp
 185                 190                 195                 200

 gat ggt aca ggt gta cag gtg tat cct gtg gaa gaa gca ttg ctt aaa      737
 Asp Gly Thr Gly Val Gln Val Tyr Pro Val Glu Glu Ala Leu Leu Lys
                 205                 210                 215

 gag tat att aag cgt caa att gaa tat tac ttc agt gta gaa aat ttg      785
 Glu Tyr Ile Lys Arg Gln Ile Glu Tyr Tyr Phe Ser Val Glu Asn Leu
             220                 225                 230

 gaa cga gac ttc ttt ctt cgg gga aag atg gat gaa caa ggt ttc ttg      833
 Glu Arg Asp Phe Phe Leu Arg Gly Lys Met Asp Glu Gln Gly Phe Leu
         235                 240                 245

 cct att tcc ctg att gct ggt ttt cag cgt gtt cag gct ctc act aca      881
 Pro Ile Ser Leu Ile Ala Gly Phe Gln Arg Val Gln Ala Leu Thr Thr
     250                 255                 260

 aac ctt aat ctc atc tta gag gca ctg aag gat agc aca gaa gta gaa      929
 Asn Leu Asn Leu Ile Leu Glu Ala Leu Lys Asp Ser Thr Glu Val Glu
 265                 270                 275                 280

 att gtg gat gag aaa atg aga aaa gag ata gaa cca gaa aaa tgg cca      977
 Ile Val Asp Glu Lys Met Arg Lys Glu Ile Glu Pro Glu Lys Trp Pro
                 285                 290                 295

 att cca ggc cct cct cca cgc agt gtg cca cca aca gac ttc tct caa     1025
 Ile Pro Gly Pro Pro Pro Arg Ser Val Pro Pro Thr Asp Phe Ser Gln
             300                 305                 310

 ctg att gat tgt cca gag ttt gta cca ggc caa gcc ttt tgc tca cat     1073
 Leu Ile Asp Cys Pro Glu Phe Val Pro Gly Gln Ala Phe Cys Ser His
         315                 320                 325

 aca gag tct gcc cca aat tct cca aga att gga agc cca ttg agc cca     1121
 Thr Glu Ser Ala Pro Asn Ser Pro Arg Ile Gly Ser Pro Leu Ser Pro
     330                 335                 340

 aag aaa aac agt gaa aca agt att ctt caa gca atg tct aga ggt ttg     1169
 Lys Lys Asn Ser Glu Thr Ser Ile Leu Gln Ala Met Ser Arg Gly Leu
 345                 350                 355                 360

 tct acc agt ttg cct gac ttg gac tca gaa cct tgg ata gaa gtt aaa     1217
 Ser Thr Ser Leu Pro Asp Leu Asp Ser Glu Pro Trp Ile Glu Val Lys
                 365                 370                 375

 aaa aga cat cag cca gcc cca gtg aaa ttg agg gaa tca gtg tct gtc     1265
 Lys Arg His Gln Pro Ala Pro Val Lys Leu Arg Glu Ser Val Ser Val
             380                 385                 390

 cct gaa ggg tca tta aat cag cta tgt tct tca gaa gaa cca gaa caa     1313
 Pro Glu Gly Ser Leu Asn Gln Leu Cys Ser Ser Glu Glu Pro Glu Gln
         395                 400                 405

 gaa gaa ctt gat ttt ttg ttt gat gaa gag att gaa caa ata gga cga     1361
 Glu Glu Leu Asp Phe Leu Phe Asp Glu Glu Ile Glu Gln Ile Gly Arg
     410                 415                 420

 aaa aac aca ttt act gat tgg tct gat aat gat tca gat tat gaa att     1409
 Lys Asn Thr Phe Thr Asp Trp Ser Asp Asn Asp Ser Asp Tyr Glu Ile
 425                 430                 435                 440

 gat gac caa gac tta aac aag att ttg att gta act cag aca cca cct     1457
 Asp Asp Gln Asp Leu Asn Lys Ile Leu Ile Val Thr Gln Thr Pro Pro
                 445                 450                 455

 tat gtg aaa aaa cat cgt gga gga gat cga aca ggc acc cac atg tct     1505
 Tyr Val Lys Lys His Arg Gly Gly Asp Arg Thr Gly Thr His Met Ser
             460                 465                 470

 cgg gca aaa atc aca tct gaa ctt gct aaa gtt atc aat gat ggc tta     1553
 Arg Ala Lys Ile Thr Ser Glu Leu Ala Lys Val Ile Asn Asp Gly Leu
         475                 480                 485

 tat tat tat gaa cag gat cta tgg atg gaa gaa gat gaa aac aaa cac     1601
 Tyr Tyr Tyr Glu Gln Asp Leu Trp Met Glu Glu Asp Glu Asn Lys His
     490                 495                 500

 aca gcc ata aag caa gaa gtt gag aac ttt aag aag cta aat ctc att     1649
 Thr Ala Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Leu Asn Leu Ile
 505                 510                 515                 520

 agt aaa gag cag ttt gaa aac cta aca cct gaa ctt cct ttt gag cca     1697
 Ser Lys Glu Gln Phe Glu Asn Leu Thr Pro Glu Leu Pro Phe Glu Pro
                 525                 530                 535

 aac caa gaa gtt cct gta gca cct tca cag tcc agg caa gga ggt gtt     1745
 Asn Gln Glu Val Pro Val Ala Pro Ser Gln Ser Arg Gln Gly Gly Val
             540                 545                 550

 caa gga gtg ctt cac att ccc aag aaa gat ttg act gat gaa tta gct     1793
 Gln Gly Val Leu His Ile Pro Lys Lys Asp Leu Thr Asp Glu Leu Ala
         555                 560                 565

 cag aag tta ttt gat gtt tca gaa ata act tca gca gca atg gtt cat     1841
 Gln Lys Leu Phe Asp Val Ser Glu Ile Thr Ser Ala Ala Met Val His
     570                 575                 580

 tcg ttg cct aca gca gtt cca gaa tct cct aga att cat cct aca aga     1889
 Ser Leu Pro Thr Ala Val Pro Glu Ser Pro Arg Ile His Pro Thr Arg
 585                 590                 595                 600

 aca ccc aaa aca cct cga aca cct agg tta caa gat cct aac aaa aca     1937
 Thr Pro Lys Thr Pro Arg Thr Pro Arg Leu Gln Asp Pro Asn Lys Thr
                 605                 610                 615

 cca aga ttt tat cct gtt gtt aaa gaa cca aaa gcc att gat gta aag     1985
 Pro Arg Phe Tyr Pro Val Val Lys Glu Pro Lys Ala Ile Asp Val Lys
             620                 625                 630

 agt cca aga aag aga aaa aca agg cat agc aca aat ccc cct cta gag     2033
 Ser Pro Arg Lys Arg Lys Thr Arg His Ser Thr Asn Pro Pro Leu Glu
         635                 640                 645

 tgt cat gtt ggt tgg gta atg gat tcc aga gac cat ggg cca gga aca     2081
 Cys His Val Gly Trp Val Met Asp Ser Arg Asp His Gly Pro Gly Thr
     650                 655                 660

 tcc tct gtc agc act tca aat gct tca cct tca gaa ggc gca cca cta     2129
 Ser Ser Val Ser Thr Ser Asn Ala Ser Pro Ser Glu Gly Ala Pro Leu
 665                 670                 675                 680

 gca gga agt tat gga tgt act cct cat tca ttc cca aag ttc cag cat     2177
 Ala Gly Ser Tyr Gly Cys Thr Pro His Ser Phe Pro Lys Phe Gln His
                 685                 690                 695

 cct tct cat gaa ctt ttg aag gaa aat ggc ttt acc caa caa gtg tac     2225
 Pro Ser His Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln Gln Val Tyr
             700                 705                 710

 cac aag tat cgt cga aga tgc cta agt gag aga aaa cgc ttg gga att     2273
 His Lys Tyr Arg Arg Arg Cys Leu Ser Glu Arg Lys Arg Leu Gly Ile
         715                 720                 725

 ggt cag tcc caa gaa atg aat acc ctc ttt cgt ttc tgg tcc ttt ttc     2321
 Gly Gln Ser Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe
     730                 735                 740

 ctc aga gat cac ttc aat aaa aaa atg tat gag gaa ttt aga caa ctt     2369
 Leu Arg Asp His Phe Asn Lys Lys Met Tyr Glu Glu Phe Arg Gln Leu
 745                 750                 755                 760

 gct tgg gaa gat gca aaa gaa aat tac agg tat ggg tta gaa tgt ctg     2417
 Ala Trp Glu Asp Ala Lys Glu Asn Tyr Arg Tyr Gly Leu Glu Cys Leu
                 765                 770                 775

 ttc agg ttt tat agt tat gga ctg gaa aaa aaa ttc agg cga gaa att     2465
 Phe Arg Phe Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Arg Glu Ile
             780                 785                 790

 ttt cag gat ttc caa gaa gaa acc aaa aaa gac tac gaa tct ggt cag     2513
 Phe Gln Asp Phe Gln Glu Glu Thr Lys Lys Asp Tyr Glu Ser Gly Gln
         795                 800                 805

 ctg tat gga cta gaa aag ttt tgg gct tat ttg aaa tat tct caa tct     2561
 Leu Tyr Gly Leu Glu Lys Phe Trp Ala Tyr Leu Lys Tyr Ser Gln Ser
     810                 815                 820

 aag aca cag tct att gac cca aaa ctt cag gaa tac ctc tgt agt ttt     2609
 Lys Thr Gln Ser Ile Asp Pro Lys Leu Gln Glu Tyr Leu Cys Ser Phe
 825                 830                 835                 840

 aag agg tta gaa gac ttc cgt gtt gat ccc cct att agt gat gaa ttt     2657
 Lys Arg Leu Glu Asp Phe Arg Val Asp Pro Pro Ile Ser Asp Glu Phe
                 845                 850                 855

 gga aga aaa aga cat tcc tct act tct ggt gag gag agt aat cgt cat     2705
 Gly Arg Lys Arg His Ser Ser Thr Ser Gly Glu Glu Ser Asn Arg His
             860                 865                 870

 aga ctt cca cct aat tcc tct aca aag cca cca aat gct gct aaa cct     2753
 Arg Leu Pro Pro Asn Ser Ser Thr Lys Pro Pro Asn Ala Ala Lys Pro
         875                 880                 885

 aca tct acc agt gag ctt cag gta cca ata aac tct ccc aga agg aat     2801
 Thr Ser Thr Ser Glu Leu Gln Val Pro Ile Asn Ser Pro Arg Arg Asn
     890                 895                 900

 att tca ccg gag tcc agt gac aat tca cat taa acagtgct gcctgtgtcc     2852
 Ile Ser Pro Glu Ser Ser Asp Asn Ser His 
 905                 910

 tgtggtctca agaaatggtg aaatgcctga gaaatagact cttatgaaag ttctttgtcc   2912

 ttgaagtcaa catttacatc agtatttatt tggggaaaat cttctggtgt ttaattgtga   2972

 taataagaaa gaagaaaaag aaagaaaagt ggtagcattt tttctaacaa gataaattct   3032

 aaaaatgttt tccctgattt cacaaacaag gatagtcttg gtgacctttt atagagatct   3092

 tctagtaatg tattttgatc tcagatttct ttttcaaagc catggtttta caaaaacagc   3152

 attccttaaa tatatttaaa aaacaataca aggaatgcct aacatttcag ctcatacttc   3212

 ttaaagaaga tatagtatgt tgtattctct tcttagagct ttcttaaaga atccacaatc   3272

 caattacccc actgtcaatt catatttgaa cttaccaaaa caaaggagga ttacgtatat   3332

 gttttttaaa ttcaaaaaag aatatgaaat tataccttta gtatcccttt gagacatata   3392

 gtttaaagaa aacttttttt aaaacaaaag taggaatata tagtaagatt gtagttacaa   3452

 tgagtatatg cacttttgat gctaggtttt gcttttctcc ccccagtcat atctcatgat   3512

 ttccacagtt gttgtattgg tgtggagttt tctgaattgg ctataagctg attacatatt   3572

 agaggtttat ttttatgatt ctatataaac gtgcacgagt aatttaaaac ctgcattggg   3632

 attgattgga atattgtcct aaattaatta aatcttgcac tgttttgaat gcatctgcta   3692

 tttatacatc tgcaagtggg tatgtcataa ggagtcagat tatctttaat ttaaaatgaa   3752

 tacttagttt tacctttttg tttatttttt gtttaatttt gtttttataa atgttttcaa   3812

 gagttatagc aaattgattt ctaattttta ttgctattac aactgatgta aatggtagtt   3872

 tcagtttttg tgagatttaa aaaaataaag cacttattct g                       3913




      <210> 27
      <211> 2434
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(1850)

      <400> 27
 aggccccagg acatgcagaa ccttcctcta gaacccgacc caccacc  atg agg tcc      56
                                                      Met Arg Ser
                                                        1

 tgc ctg tgg aga tgc agg cac ctg agc caa ggc gtc cag tgg tcc ttg      104
 Cys Leu Trp Arg Cys Arg His Leu Ser Gln Gly Val Gln Trp Ser Leu
       5                  10                  15

 ctt ctg gct gtc ctg gtc ttc ttt ctc ttc gcc ttg ccc tct ttt att      152
 Leu Leu Ala Val Leu Val Phe Phe Leu Phe Ala Leu Pro Ser Phe Ile
  20                  25                  30                  35

 aag gag cct caa aca aag cct tcc agg cat caa cgc aca gag aac att      200
 Lys Glu Pro Gln Thr Lys Pro Ser Arg His Gln Arg Thr Glu Asn Ile
                  40                  45                  50

 aaa gaa agg tct cta cag tcc ctg gca aag cct aag tcc cag gca ccc      248
 Lys Glu Arg Ser Leu Gln Ser Leu Ala Lys Pro Lys Ser Gln Ala Pro
              55                  60                  65

 aca agg gca agg agg aca acc atc tat gca gag cca gtg cca gag aac      296
 Thr Arg Ala Arg Arg Thr Thr Ile Tyr Ala Glu Pro Val Pro Glu Asn
          70                  75                  80

 aat gcc ctc aac aca caa acc cag ccc aag gcc cac acc acc gga gac      344
 Asn Ala Leu Asn Thr Gln Thr Gln Pro Lys Ala His Thr Thr Gly Asp
      85                  90                  95

 aga gga aag gag gcc aac cag gca ccg ccg gag gag cag gac aag gtg      392
 Arg Gly Lys Glu Ala Asn Gln Ala Pro Pro Glu Glu Gln Asp Lys Val
 100                 105                 110                 115

 ccc cac aca gca cag agg gca gca tgg aag agc cca gaa aaa gag aaa      440
 Pro His Thr Ala Gln Arg Ala Ala Trp Lys Ser Pro Glu Lys Glu Lys
                 120                 125                 130

 acc atg gtg aac aca ctg tca ccc aga ggg caa gat gca ggg atg gcc      488
 Thr Met Val Asn Thr Leu Ser Pro Arg Gly Gln Asp Ala Gly Met Ala
             135                 140                 145

 tct ggc agg aca gag gca caa tca tgg aag agc cag gac aca aag acg      536
 Ser Gly Arg Thr Glu Ala Gln Ser Trp Lys Ser Gln Asp Thr Lys Thr
         150                 155                 160

 acc caa gga aat ggg ggc cag acc agg aag ctg acg gcc tcc agg acg      584
 Thr Gln Gly Asn Gly Gly Gln Thr Arg Lys Leu Thr Ala Ser Arg Thr
     165                 170                 175

 gtg tca gag aag cac cag ggc aaa gcg gca acc aca gcc aag acg ctc      632
 Val Ser Glu Lys His Gln Gly Lys Ala Ala Thr Thr Ala Lys Thr Leu
 180                 185                 190                 195

 att ccc aaa agt cag cac aga atg ctg gct ccc aca gga gca gtg tca      680
 Ile Pro Lys Ser Gln His Arg Met Leu Ala Pro Thr Gly Ala Val Ser
                 200                 205                 210

 aca agg acg aga cag aaa gga gtg acc aca gca gtc atc cca cct aag      728
 Thr Arg Thr Arg Gln Lys Gly Val Thr Thr Ala Val Ile Pro Pro Lys
             215                 220                 225

 gag aag aaa cct cag gcc acc cca ccc cct gcc cct ttc cag agc ccc      776
 Glu Lys Lys Pro Gln Ala Thr Pro Pro Pro Ala Pro Phe Gln Ser Pro
         230                 235                 240

 acg acg cag aga aac caa aga ctg aag gcc gcc aac ttc aaa tct gag      824
 Thr Thr Gln Arg Asn Gln Arg Leu Lys Ala Ala Asn Phe Lys Ser Glu
     245                 250                 255

 cct cgg tgg gat ttt gag gaa aaa tac agc ttc gaa ata gga ggc ctt      872
 Pro Arg Trp Asp Phe Glu Glu Lys Tyr Ser Phe Glu Ile Gly Gly Leu
 260                 265                 270                 275

 cag acg act tgc cct gac tct gtg aag atc aaa gcc tcc aag tcg ctg      920
 Gln Thr Thr Cys Pro Asp Ser Val Lys Ile Lys Ala Ser Lys Ser Leu
                 280                 285                 290

 tgg ctc cag aaa ctc ttt ctg ccc aac ctc act ctc ttc ctg gac tcc      968
 Trp Leu Gln Lys Leu Phe Leu Pro Asn Leu Thr Leu Phe Leu Asp Ser
             295                 300                 305

 aga cac ttc aac cag agt gag tgg gac cgc ctg gaa cac ttt gca cca     1016
 Arg His Phe Asn Gln Ser Glu Trp Asp Arg Leu Glu His Phe Ala Pro
         310                 315                 320

 ccc ttt ggc ttc atg gag ctc aac tac tcc ttg gtg cag aag gtc gtg     1064
 Pro Phe Gly Phe Met Glu Leu Asn Tyr Ser Leu Val Gln Lys Val Val
     325                 330                 335

 aca cgc ttc cct cca gtg ccc cag cag cag ctg ctc ctg gcc agc ctc     1112
 Thr Arg Phe Pro Pro Val Pro Gln Gln Gln Leu Leu Leu Ala Ser Leu
 340                 345                 350                 355

 ccc gct ggg agc ctc cgg tgc atc acc tgt gcc gtg gtg ggc aac ggg     1160
 Pro Ala Gly Ser Leu Arg Cys Ile Thr Cys Ala Val Val Gly Asn Gly
                 360                 365                 370

 ggc atc ctg aac aac tcc cac atg ggc cag gag ata gac agt cac gac     1208
 Gly Ile Leu Asn Asn Ser His Met Gly Gln Glu Ile Asp Ser His Asp
             375                 380                 385

 tac gtg ttc cga ttg agc gga gct ctc att aaa ggc tac gaa cag gat     1256
 Tyr Val Phe Arg Leu Ser Gly Ala Leu Ile Lys Gly Tyr Glu Gln Asp
         390                 395                 400

 gtg ggg act cgg aca tcc ttc tac ggc ttt acc gcc ttc tcc ctg acc     1304
 Val Gly Thr Arg Thr Ser Phe Tyr Gly Phe Thr Ala Phe Ser Leu Thr
     405                 410                 415

 cag tca ctc ctt ata ttg ggc aat cgg ggt ttc aag aac gtg cct ctt     1352
 Gln Ser Leu Leu Ile Leu Gly Asn Arg Gly Phe Lys Asn Val Pro Leu
 420                 425                 430                 435

 ggg aag gac gtc cgc tac ttg cac ttc ctg gaa ggc acc cgg gac tat     1400
 Gly Lys Asp Val Arg Tyr Leu His Phe Leu Glu Gly Thr Arg Asp Tyr
                 440                 445                 450

 gag tgg ctg gaa gca ctg ctt atg aat cag acg gtg atg tca aaa aac     1448
 Glu Trp Leu Glu Ala Leu Leu Met Asn Gln Thr Val Met Ser Lys Asn
             455                 460                 465

 ctt ttc tgg ttc agg cac aga ccc cag gaa gct ttt cgg gaa gcc ctg     1496
 Leu Phe Trp Phe Arg His Arg Pro Gln Glu Ala Phe Arg Glu Ala Leu
         470                 475                 480

 cac atg gac agg tac ctg ttg ctg cac cca gac ttt ctc cga tac atg     1544
 His Met Asp Arg Tyr Leu Leu Leu His Pro Asp Phe Leu Arg Tyr Met
     485                 490                 495

 aag aac agg ttt ctg agg tct aag acc ctg gat ggt gcc cac tgg agg     1592
 Lys Asn Arg Phe Leu Arg Ser Lys Thr Leu Asp Gly Ala His Trp Arg
 500                 505                 510                 515

 ata tac cgc ccc acc act ggg gcc ctc ctg ctg ctc act gcc ctt cag     1640
 Ile Tyr Arg Pro Thr Thr Gly Ala Leu Leu Leu Leu Thr Ala Leu Gln
                 520                 525                 530

 ctc tgt gac cag gtg agt gct tat ggc ttc atc act gag ggc cat gag     1688
 Leu Cys Asp Gln Val Ser Ala Tyr Gly Phe Ile Thr Glu Gly His Glu
             535                 540                 545

 cgc ttt tct gat cac tac tat gat aca tca tgg aag cgg ctg atc ttt     1736
 Arg Phe Ser Asp His Tyr Tyr Asp Thr Ser Trp Lys Arg Leu Ile Phe
         550                 555                 560

 tac ata aac cat gac ttc aag ctg gag aga gaa gtc tgg aag cgg cta     1784
 Tyr Ile Asn His Asp Phe Lys Leu Glu Arg Glu Val Trp Lys Arg Leu
     565                 570                 575

 cac gat gaa ggg ata atc cgg ctg tac cag cgt cct ggt ccc gga act     1832
 His Asp Glu Gly Ile Ile Arg Leu Tyr Gln Arg Pro Gly Pro Gly Thr
 580                 585                 590                 595

 gcc aaa gcc aag aac tga ccgggg ccagggctgc catggtctcc ttgcctgctc     1886
 Ala Lys Ala Lys Asn 
                 600

 caaggcacag gatacagtgg gaatcttgag actctttggc catttcccat ggctcagact   1946

 aagctccaag cccttcagga gttccaaggg aacacttgaa ccatggacaa gactctctca   2006

 agatggcaaa tggctaattg aggttctgaa gttcttcagt acattgctgt aggtcctgag   2066

 gccagggatt tttaattaaa tggggtgatg ggtggccaat accacaattc ctgctgaaaa   2126

 acactcttcc agtccaaaag cttcttgata cagaaaaaag agcctggatt tacagaaaca   2186

 tatagatctg gtttgaattc cagatcgagt ttacagttgt gaaatcttga aggtattact   2246

 taacttcact acagattgtc tagaagacct ttctaggagt tatctgattc tagaagggtc   2306

 tatacttgtc cttgtcttta agctatttga caactctacg tgttgtagaa aactgataat   2366

 aatacaaatg attgttgtcc atggaaaggc aaataaattt tctacagtga agatgtaaaa   2426

 aaaaaaaa                                                            2434




      <210> 28
      <211> 1108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (479)..(1018)

      <400> 28
 ctaagtccca cagagacggg attcgggtgg gatcccaggc tgggccccgc ggcggctgga     60

 ttctcttccc tggccaagtc tctgagatct tctcccaggg cgatgcaaag ctactcgcta    120

 ccagcttgga cctgtctgca gtatctcctc tgggacctgc catgctgagg acccattctc    180

 acctctgagg gactcctgtc ctaggactaa ggtggagcct gggccatggt acagctggct    240

 cctgcggcag ccatggacga ggtcaccttt aggagcgaca ctgtgctgtc agatgtccac    300

 ctctataccc cgaaccatag acatctcatg gtacggctga acagcgtggg gcagccaggt    360

 gtggcggggc gccctgctcc tggcagacta catcctgttc cgacaggacc tcttccgagg    420

 atgtacagcg ctggagctcg gggccggcac ggggctcgct agcatcatcg cagccacc      478                                                                 
 atg gca cgg acc gtt tat tgt aca gat gtc ggt gca gat ctc ttg tcc      526
 Met Ala Arg Thr Val Tyr Cys Thr Asp Val Gly Ala Asp Leu Leu Ser
   1               5                  10                  15

 atg tgc cag cga aac att gcc ctc aac agc cac ctg gct gcc act gga      574
 Met Cys Gln Arg Asn Ile Ala Leu Asn Ser His Leu Ala Ala Thr Gly
              20                  25                  30

 ggt ggt ata gtt agg gtc aaa gaa ctg gac tgg ctg aag gac gac ctc      622
 Gly Gly Ile Val Arg Val Lys Glu Leu Asp Trp Leu Lys Asp Asp Leu
          35                  40                  45

 tgc aca gat ccc aag gtc ccc ttc agt tgg tca caa gag gaa att tct      670
 Cys Thr Asp Pro Lys Val Pro Phe Ser Trp Ser Gln Glu Glu Ile Ser
      50                  55                  60

 gac ctg tac gat cac acc acc atc ctg ttt gca gcc gaa gtg ttt tac      718
 Asp Leu Tyr Asp His Thr Thr Ile Leu Phe Ala Ala Glu Val Phe Tyr
  65                  70                  75                  80

 gac gac gac ttg act gat gct gtg ttt aaa acg ctc tcc cga ctc gcc      766
 Asp Asp Asp Leu Thr Asp Ala Val Phe Lys Thr Leu Ser Arg Leu Ala
                  85                  90                  95

 cac aga ttg aaa aat gcc tgc aca gcc ata ctg tcg gtg gag aag agg      814
 His Arg Leu Lys Asn Ala Cys Thr Ala Ile Leu Ser Val Glu Lys Arg
             100                 105                 110

 ctc aac ttc aca ctg aga cac ttg gac gtc aca tgt gaa gcc tac gat      862
 Leu Asn Phe Thr Leu Arg His Leu Asp Val Thr Cys Glu Ala Tyr Asp
         115                 120                 125

 cac ttc cgc tcc tgc ctg cac gcg ctg gag cag ctc aca gat ggc aag      910
 His Phe Arg Ser Cys Leu His Ala Leu Glu Gln Leu Thr Asp Gly Lys
     130                 135                 140

 ctg cgc ttc gtg gtg gag ccc gtg gag gcc tcc ttc cca cag ctc ctg      958
 Leu Arg Phe Val Val Glu Pro Val Glu Ala Ser Phe Pro Gln Leu Leu
 145                 150                 155                 160

 gtt tac gag cgc ctc cag cag ctg gag ctc tgg aag atc atc gca gaa     1006
 Val Tyr Glu Arg Leu Gln Gln Leu Glu Leu Trp Lys Ile Ile Ala Glu
                 165                 170                 175

 cca gta aca tga ccc atcgcctcca ccaggcgcgg cgtctcgact gttcttagag     1061
 Pro Val Thr 


 tgtatttcta gtaaaatcag aagctcacca aagcaaaaaa aaaaaaa                 1108




      <210> 29
      <211> 1538
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(1448)

      <400> 29
 gcggccgcct aagtcccaca gagacgggag tcgggtggga tcccaggctg ggccccgcgg     60

 cggctggatt ctcttccctg gccaagtctc tgagatcttc tcccagggcg atgcaaagct    120

 actcgctacc agcttggacc tgtctgcagt atctcctctg ggacctgcca tgctgaggac    180

 ccattctcac ctctgaggga ctcctgtcct aggactaagg tggagcctgg gcc   atg     236
                                                              Met
                                                                1

 gta cag ctg gct cct gcg gca gcc atg gac gag gtc acc ttt agg agc      284
 Val Gln Leu Ala Pro Ala Ala Ala Met Asp Glu Val Thr Phe Arg Ser
               5                  10                  15

 gac act gtg ctg tca gat gtc cac ctc tat acc ccg aac cat aga cat      332
 Asp Thr Val Leu Ser Asp Val His Leu Tyr Thr Pro Asn His Arg His
          20                  25                  30

 ctc atg gta cgg ctg aac agc gtg ggg cag cca gtt ttc ctg tcc caa      380
 Leu Met Val Arg Leu Asn Ser Val Gly Gln Pro Val Phe Leu Ser Gln
      35                  40                  45

 ttc aag ctt cta tgg agc caa gac tct tgg aca gat tca gga gcc aag      428
 Phe Lys Leu Leu Trp Ser Gln Asp Ser Trp Thr Asp Ser Gly Ala Lys
  50                  55                  60                  65

 ggt ggc agt cac aga gat gtt cac aca aag gag cct cct tct gct gag      476
 Gly Gly Ser His Arg Asp Val His Thr Lys Glu Pro Pro Ser Ala Glu
                  70                  75                  80

 aca ggc agc aca ggg tcc cct cca gga agt ggc cat ggt aat gag ggt      524
 Thr Gly Ser Thr Gly Ser Pro Pro Gly Ser Gly His Gly Asn Glu Gly
              85                  90                  95

 ttc tcc ctc cag gcc ggg act gac acc act ggc cag gaa gtg gct gaa      572
 Phe Ser Leu Gln Ala Gly Thr Asp Thr Thr Gly Gln Glu Val Ala Glu
         100                 105                 110

 gct cag ctg gat gag gat ggg gat ttg gac gtg gtg aga aga cca cga      620
 Ala Gln Leu Asp Glu Asp Gly Asp Leu Asp Val Val Arg Arg Pro Arg
     115                 120                 125

 gcc gcc tct gat tcc aac cca gca ggg cct ctg aga gac aag gta cat      668
 Ala Ala Ser Asp Ser Asn Pro Ala Gly Pro Leu Arg Asp Lys Val His
 130                 135                 140                 145

 ccc atg att cta gca cag gaa gaa gac gac gtc ctg gga gag gaa gca      716
 Pro Met Ile Leu Ala Gln Glu Glu Asp Asp Val Leu Gly Glu Glu Ala
                 150                 155                 160

 caa ggc agc ccg cac gat atc atc aga ata gag cac acc atg gcc acg      764
 Gln Gly Ser Pro His Asp Ile Ile Arg Ile Glu His Thr Met Ala Thr
             165                 170                 175

 ccc ctg gag gat gtt ggc aag cag gtg tgc ggg ggc gcc ctg ctc ctg      812
 Pro Leu Glu Asp Val Gly Lys Gln Val Cys Gly Gly Ala Leu Leu Leu
         180                 185                 190

 gca gac tac atc ctg ttc cga cag gac ctc ttc cga gga tgt aca gcg      860
 Ala Asp Tyr Ile Leu Phe Arg Gln Asp Leu Phe Arg Gly Cys Thr Ala
     195                 200                 205

 ctg gag ctc ggg gcc ggc acg ggg ctc gct agc atc atc gca gcc acc      908
 Leu Glu Leu Gly Ala Gly Thr Gly Leu Ala Ser Ile Ile Ala Ala Thr
 210                 215                 220                 225

 atg gca cgg acc gtt tat tgt aca gat gtc ggt gca gat ctc ttg tcc      956
 Met Ala Arg Thr Val Tyr Cys Thr Asp Val Gly Ala Asp Leu Leu Ser
                 230                 235                 240

 atg tgc cag cga aac att gcc ctc aac agc cac ctg gct gcc act gga     1004
 Met Cys Gln Arg Asn Ile Ala Leu Asn Ser His Leu Ala Ala Thr Gly
             245                 250                 255

 ggt ggt ata gtt agg gtc aaa gaa ctg gac tgg ctg aag gac gac ctc     1052
 Gly Gly Ile Val Arg Val Lys Glu Leu Asp Trp Leu Lys Asp Asp Leu
         260                 265                 270

 tgc aca gat ccc aag gtc ccc ttc agt tgg tca caa gag gaa att tct     1100
 Cys Thr Asp Pro Lys Val Pro Phe Ser Trp Ser Gln Glu Glu Ile Ser
     275                 280                 285

 gac ctg tac gat cac acc acc atc ctg ttt gca gcc gaa gtg ttt tac     1148
 Asp Leu Tyr Asp His Thr Thr Ile Leu Phe Ala Ala Glu Val Phe Tyr
 290                 295                 300                 305

 gac gac gac ttg act gat gct gtg ttt aaa acg ctc tcc cga ctc gcc     1196
 Asp Asp Asp Leu Thr Asp Ala Val Phe Lys Thr Leu Ser Arg Leu Ala
                 310                 315                 320

 cac aga ttg aaa aat gcc tgc aca gcc ata ctg tcg gtg gag aag agg     1244
 His Arg Leu Lys Asn Ala Cys Thr Ala Ile Leu Ser Val Glu Lys Arg
             325                 330                 335

 ctc aac ttc aca ctg aga cac ttg gac gtc aca tgt gaa gcc tac gat     1292
 Leu Asn Phe Thr Leu Arg His Leu Asp Val Thr Cys Glu Ala Tyr Asp
         340                 345                 350

 cac ttc cgc tcc tgc ctg cac gcg ctg gag cag ctc aca gat ggc aag     1340
 His Phe Arg Ser Cys Leu His Ala Leu Glu Gln Leu Thr Asp Gly Lys
     355                 360                 365

 ctg cgc ttc gtg gtg gag ccc gtg gag gcc tcc ttc cca cag ctc ctg     1388
 Leu Arg Phe Val Val Glu Pro Val Glu Ala Ser Phe Pro Gln Leu Leu
 370                 375                 380                 385

 gtt tac gag cgc ctc cag cag ctg gag ctc tgg aag atc atc gca gaa     1436
 Val Tyr Glu Arg Leu Gln Gln Leu Glu Leu Trp Lys Ile Ile Ala Glu
                 390                 395                 400

 cca gta aca tga ccc atcgcctcca ccaggcgcgg cgtctcgact gttcttagag     1491
 Pro Val Thr 


 tgtatttcta gtaaaatcag aagctcacca aagcaaaaaa aaaaaaa                 1538




      <210> 30
      <211> 1392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1194)

      <400> 30
 aac  atg gcg gcg ccc tgt gtg tcc tac ggc gga gca gtt tcg tac cgg      48
      Met Ala Ala Pro Cys Val Ser Tyr Gly Gly Ala Val Ser Tyr Arg
        1               5                  10                  15

 ctt ctt ctc tgg ggt agg ggt agc ctc gcc cgg aag caa ggc ctc tgg       96
 Leu Leu Leu Trp Gly Arg Gly Ser Leu Ala Arg Lys Gln Gly Leu Trp
                  20                  25                  30

 aaa acc gcg gcc cct gag ttg caa aca aat gtc aga tcc cag ata tta      144
 Lys Thr Ala Ala Pro Glu Leu Gln Thr Asn Val Arg Ser Gln Ile Leu
              35                  40                  45

 agg cta aga cat act gca ttt gta ata cca aag aaa aac gtt cct acc      192
 Arg Leu Arg His Thr Ala Phe Val Ile Pro Lys Lys Asn Val Pro Thr
          50                  55                  60

 tca aaa cgt gaa act tac aca gag gat ttt att aaa aag cag att gaa      240
 Ser Lys Arg Glu Thr Tyr Thr Glu Asp Phe Ile Lys Lys Gln Ile Glu
      65                  70                  75

 gag ttc aac ata gga aag aga cat tta gcc aac atg atg gga gaa gat      288
 Glu Phe Asn Ile Gly Lys Arg His Leu Ala Asn Met Met Gly Glu Asp
  80                  85                  90                  95

 cca gaa act ttc act caa gaa gat att gac aga gct att gct tac ctt      336
 Pro Glu Thr Phe Thr Gln Glu Asp Ile Asp Arg Ala Ile Ala Tyr Leu
                 100                 105                 110

 ttc cca agt ggt ttg ttt gag aaa cga gcc agg cca gta atg aag cat      384
 Phe Pro Ser Gly Leu Phe Glu Lys Arg Ala Arg Pro Val Met Lys His
             115                 120                 125

 cct gaa cag att ttt cca aga caa aga gca atc cag tgg gga gaa gat      432
 Pro Glu Gln Ile Phe Pro Arg Gln Arg Ala Ile Gln Trp Gly Glu Asp
         130                 135                 140

 ggc cgt cca ttt cac tat ctc ttc tat act ggc aaa cag tca tac tat      480
 Gly Arg Pro Phe His Tyr Leu Phe Tyr Thr Gly Lys Gln Ser Tyr Tyr
     145                 150                 155

 tca tta atg cat gat gta tat gga atg tta ctc aat tta gaa aaa cat      528
 Ser Leu Met His Asp Val Tyr Gly Met Leu Leu Asn Leu Glu Lys His
 160                 165                 170                 175

 caa agt cac ttg caa gcc aaa agt ctg ctc cca gaa aaa act gta acc      576
 Gln Ser His Leu Gln Ala Lys Ser Leu Leu Pro Glu Lys Thr Val Thr
                 180                 185                 190

 aga gac gtg att ggc agc aga tgg ctg att aag gag gaa cta gaa gaa      624
 Arg Asp Val Ile Gly Ser Arg Trp Leu Ile Lys Glu Glu Leu Glu Glu
             195                 200                 205

 atg tta gtg gaa aaa ctg tca gat cta gat tat atg cag ttc att cgg      672
 Met Leu Val Glu Lys Leu Ser Asp Leu Asp Tyr Met Gln Phe Ile Arg
         210                 215                 220

 ctg cta gaa aag tta ttg aca tcg cag tgt ggt gct gct gag gaa gaa      720
 Leu Leu Glu Lys Leu Leu Thr Ser Gln Cys Gly Ala Ala Glu Glu Glu
     225                 230                 235

 ttt gtg cag agg ttt cga aga agt gta act ctt gaa tca aaa aaa cag      768
 Phe Val Gln Arg Phe Arg Arg Ser Val Thr Leu Glu Ser Lys Lys Gln
 240                 245                 250                 255

 ctg att gaa cct gta cag tat gat gag caa gga atg gcc ttt agc aaa      816
 Leu Ile Glu Pro Val Gln Tyr Asp Glu Gln Gly Met Ala Phe Ser Lys
                 260                 265                 270

 agc gaa ggt aaa aga aag act gca aaa gca gaa gca att gtt tat aaa      864
 Ser Glu Gly Lys Arg Lys Thr Ala Lys Ala Glu Ala Ile Val Tyr Lys
             275                 280                 285

 cat gga agt gga aga ata aaa gta aat gga att gat tac cag ctt tac      912
 His Gly Ser Gly Arg Ile Lys Val Asn Gly Ile Asp Tyr Gln Leu Tyr
         290                 295                 300

 ttc ccg atc aca cag gac aga gaa cag ctg atg ttc cct ttc cac ttt      960
 Phe Pro Ile Thr Gln Asp Arg Glu Gln Leu Met Phe Pro Phe His Phe
     305                 310                 315

 gtt gac cgg ctg gga aag cac gac gtg acc tgc aca gtc tca ggg ggc     1008
 Val Asp Arg Leu Gly Lys His Asp Val Thr Cys Thr Val Ser Gly Gly
 320                 325                 330                 335

 ggg agg tca gcg cag gct gga gca ata cga ctg gca atg gca aaa gcc     1056
 Gly Arg Ser Ala Gln Ala Gly Ala Ile Arg Leu Ala Met Ala Lys Ala
                 340                 345                 350

 ttg tgc agc ttt gtc acc gag gac gag gtc gag tgg atg aga caa gct     1104
 Leu Cys Ser Phe Val Thr Glu Asp Glu Val Glu Trp Met Arg Gln Ala
             355                 360                 365

 gga cta ctt act act gat cca cgt gtg agg gaa cgg aag aag cca ggc     1152
 Gly Leu Leu Thr Thr Asp Pro Arg Val Arg Glu Arg Lys Lys Pro Gly
         370                 375                 380

 caa gag gga gcc cgc aga aag ttt acg tgg aag aaa cgc taa gggtttg     1201
 Gln Glu Gly Ala Arg Arg Lys Phe Thr Trp Lys Lys Arg 
     385                 390                 395

 ctcccaggaa aggagaggaa gagctatata tatgtgccga catgtggcag acacacagta   1261

 aataatggct gaccagcatg agggcagtac tgtcagaaat ttctttgagc tgtgagatgg   1321

 atttattttt aaatgctact ttgtaaaggt gacctttaaa aaataaaagg aaaataaaga   1381

 aaaaaaaaaa a                                                        1392




      <210> 31
      <211> 2939
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(696)

      <400> 31
 tcggaactcg ccaggggcgc cgccggcggc ggagggagcg tgactgcgct gcgcagggcg     60

 ctaggaggca ttgtcgccgc tcaggccctt ttgtgagaag cagaccagcc tgggggctgg    120

 cggcaggaca cctgtgtctg c  atg ctg aag aag atg ggt gag gcc gtg gcc     171
                          Met Leu Lys Lys Met Gly Glu Ala Val Ala
                            1               5                  10

 aga gta gca agg aag gtc aac gag acg gtg gag agc ggc tct gac act      219
 Arg Val Ala Arg Lys Val Asn Glu Thr Val Glu Ser Gly Ser Asp Thr
                  15                  20                  25

 ctg gag ctc cac ctg gag ggg aac ttc cta cac cgc ctc ccc agc gag      267
 Leu Glu Leu His Leu Glu Gly Asn Phe Leu His Arg Leu Pro Ser Glu
              30                  35                  40

 gtc agt gcc ctg cag cac ctc aag gcc att gac ctg tcc cgg aac cag      315
 Val Ser Ala Leu Gln His Leu Lys Ala Ile Asp Leu Ser Arg Asn Gln
          45                  50                  55

 ttc cag gac ttc cct gag cag ctt acc gcc ctg ccg gcg ctg gag acc      363
 Phe Gln Asp Phe Pro Glu Gln Leu Thr Ala Leu Pro Ala Leu Glu Thr
      60                  65                  70

 atc aac ctg gag gag aac gag atc gta gat gtg ccc gtg gag aag ctg      411
 Ile Asn Leu Glu Glu Asn Glu Ile Val Asp Val Pro Val Glu Lys Leu
  75                  80                  85                  90

 gcc gcc atg cca gcc ttg cgc agc atc aac ctc cgc ttc aac cca ctc      459
 Ala Ala Met Pro Ala Leu Arg Ser Ile Asn Leu Arg Phe Asn Pro Leu
                  95                 100                 105

 aac gcc gag gtg cgc gtg atc gcc ccg ccg ctc atc aag ttt gac atg      507
 Asn Ala Glu Val Arg Val Ile Ala Pro Pro Leu Ile Lys Phe Asp Met
             110                 115                 120

 ctc atg tct ccg gaa ggc gca aga gcc ccc cta cct tac gcc acc ctc      555
 Leu Met Ser Pro Glu Gly Ala Arg Ala Pro Leu Pro Tyr Ala Thr Leu
         125                 130                 135

 ctc atg ccc acc cag caa ggg aca gag gcc aca ggc ctg gaa ccc tgg      603
 Leu Met Pro Thr Gln Gln Gly Thr Glu Ala Thr Gly Leu Glu Pro Trp
     140                 145                 150

 aag gga ggg agg ccc atg gga ggc caa gcc tgg ggg ctg ggg gcg ggt      651
 Lys Gly Gly Arg Pro Met Gly Gly Gln Ala Trp Gly Leu Gly Ala Gly
 155                 160                 165                 170

 ggg ccg agc agc acg tgg tgg gtg ggg tgc agc tgg tct gga tag ata      699
 Gly Pro Ser Ser Thr Trp Trp Val Gly Cys Ser Trp Ser Gly 
                 175                 180

 gcttacagca gtagtgggct ctggaatgcc caagggaaga ggcaaggtgg ggcctgcagc    759

 ctggactcgg cactcacagc tgctgtgcaa actcaggcag atctcctgcc ctctctgagc    819

 cttgtcactt gaaaaaaaca ggaccctttc cctcctttgg gctccctgga ggtttttaag    879

 cagtacgtgc ctccaagtta cctccagatc agcaggcaca ggtgggcatt gccaggtatt    939

 ttctgagccc ctgcgggttt gaggccttgt ttttagtgct gagagccagt tgctgccctg    999

 agaagagaag acaacctcca tctatttatt gcttcctgag aactgacctg gatgcggccc   1059

 tctgcagggc ccagtcttca gtcctgtggt ccctggactg gtgggaacct gaactaggag   1119

 tcctgggaga gctgtggtgg gaatatgggc tggcactgct gcagggcaag aacattcatg   1179

 taggagcccg aggaccagca ggctgggaat ggggagcaag tcacgtcagc tctgtcattc   1239

 cccacagtta acaaattggc ggggtgggaa gtcctgagtg ctccgtccct ctagcatcac   1299

 tcctgagctg cgggagaggt ggcccagaga acagcagagt cagttacacc tgcagctctt   1359

 gtctaaagtg attagatggc caccctcacc actgtccagt ccagcagcag cctggctgcc   1419

 ttgtcatggc ctcctggggg cagaaggcga tgtggaccac gggatttgta gccagccagc   1479

 tcccaggcca acgcccaaag ccctgatgac ctggttcttc tgaggccctc aacctggcat   1539

 cttagggtat ggtcaggcaa cagggtgacc agctgtcctg gtttcccagg acatggaact   1599

 ttcaatgcta aaactgggac attacccagc aagtggggat ggttggtccc ctaccaggag   1659

 agggcctggg gctcttgctt cccgagaacg cctgtggctt gaagaacctt gactgcttgg   1719

 tcctcaggta tctacctccc accttctcct catctgtgga gcaagccaac tcagtgcccc   1779

 agaccccacc tgatctgcat ctttgtttgc atctccagag acacctgagg gccccagagc   1839

 ttgaggcaaa gccaggccgt ccaaatcctg tgtgccgtgg acgagtggcc actttactac   1899

 tcctaaggct aagatgttga gagctcagac cactgctcag agcagtaatc cctgctcaga   1959

 atgctcccag ttccctcgtc cctgcccagg tctcttgtct cttgggaagg aactgatagg   2019

 tcgggccatt gttgggccat cactgagcgc tcagtatctc aagagactct gttcattctg   2079

 ctcgtatccc aaggcctggt tggtcaaact ctgggcaaag ggttttcagg atgaggaggt   2139

 caagacagga tgtccagagc taccgagttc atctgtgggt gttgggggca agtgggggct   2199

 gaagtcctgt gcaggctgcg ctggccccac ctgccttgtg ccctggagtg gggtttctcc   2259

 ttgttgaaga agaggcatcc ttctctgatg tgcacaaaca caatgtatga ccagagcctt   2319

 gcaactcaaa gtgtggtctg tggaccagca gcggcagtga cacctgggag cttgttagga   2379

 atgcagagtc taggcctcac cctatacctc ccgactcaga ccctgcattt tagcaagacc   2439

 cccagctgat tcctataagc actttagagt ttgagaagca aggacctagg ctggggatgt   2499

 cctccgagca gagggtgaag tttctctcag ttctctccct gccacttcca gggatctgag   2559

 cctgtgttca gcctcctccc taacccaccc tgggagacac ttggcctgtt agattgttcc   2619

 agagtctgca tggcactcct gaagaaggga gtgtgacctg cagtcaccag gagatgaggg   2679

 ttaggtgtgc ccagccctcc agacccggcc tttctggtta acccctgcat gccaagctgc   2739

 ctgctgcccc aggtcctcac ctcaggcctt tgaaggggca gcttctggaa gttgttttct   2799

 cctctgcttg gagagtttgc ccttgtctgt cttggaaagt gtgggcagcc acagatgccc   2859

 ccaaatcaga gctcacagtg agtgagcccc taagcttcag tctgcaataa agaatgcatt   2919

 ggtttcaaaa aaaaaaaaaa                                               2939




      <210> 32
      <211> 555
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(508)

      <400> 32
 gaattcggac gagccgctgc ctagcgcgcg gggggcgccc cccagcccgg aggctggctt     60

 tgctacagct gaccactccg gtcaggagag agagactgag aaggct   atg gat cga     115
                                                      Met Asp Arg
                                                        1

 cta gcc cgt gga aca cag agc att cct aat gac agt cct gcc cgg ggt      163
 Leu Ala Arg Gly Thr Gln Ser Ile Pro Asn Asp Ser Pro Ala Arg Gly
       5                  10                  15

 gag ggc acc cat tct gaa gag gaa ggc ttt gcc atg gat gag gag gac      211
 Glu Gly Thr His Ser Glu Glu Glu Gly Phe Ala Met Asp Glu Glu Asp
  20                  25                  30                  35

 tct gat gga gaa ctg aat acc tgg gag ctg tca gaa ggg aca aac tgt      259
 Ser Asp Gly Glu Leu Asn Thr Trp Glu Leu Ser Glu Gly Thr Asn Cys
                  40                  45                  50

 cca ccc aag gaa cag cct ggc gat ctt ttt aat gag gac tgg gac tcg      307
 Pro Pro Lys Glu Gln Pro Gly Asp Leu Phe Asn Glu Asp Trp Asp Ser
              55                  60                  65

 gag ttg aaa gca gat caa ggg aat cca tat gat gct gac gac atc cag      355
 Glu Leu Lys Ala Asp Gln Gly Asn Pro Tyr Asp Ala Asp Asp Ile Gln
          70                  75                  80

 gag agc att tct caa gag ctt aaa cct tgg gtg tgc tgt gcc cca caa      403
 Glu Ser Ile Ser Gln Glu Leu Lys Pro Trp Val Cys Cys Ala Pro Gln
      85                  90                  95

 gga gac atg atc tat gac ccc agc tgg cac cat ccg cct cca ctg ata      451
 Gly Asp Met Ile Tyr Asp Pro Ser Trp His His Pro Pro Pro Leu Ile
 100                 105                 110                 115

 ccc tat tat tcc aag atg gtc ttt gaa aca gga cag ttt gac gat gct      499
 Pro Tyr Tyr Ser Lys Met Val Phe Glu Thr Gly Gln Phe Asp Asp Ala
                 120                 125                 130

 gaa gat tga gtgtgga gctttctgcc tttgtaggtg ggcgggcctc cacgtcaaga      555
 Glu Asp 






      <210> 33
      <211> 1085
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(618)

      <400> 33
 ctgcaggaat tcggcacgag tttgaag    atg gcg gcc ctc aag gct ctg gtg      51
                                  Met Ala Ala Leu Lys Ala Leu Val
                                    1               5

 tcc ggc tgt ggg cgg ctt ctc cgt ggg cta cta gcg ggc ccg gca gcg       99
 Ser Gly Cys Gly Arg Leu Leu Arg Gly Leu Leu Ala Gly Pro Ala Ala
      10                  15                  20

 acc agc tgg tct cgg ctt cca gct cgc ggg ttc agg gaa gtg gtg gag      147
 Thr Ser Trp Ser Arg Leu Pro Ala Arg Gly Phe Arg Glu Val Val Glu
  25                  30                  35                  40

 acc caa gaa ggg aag aca act ata att gaa ggc cgt atc aca gcg act      195
 Thr Gln Glu Gly Lys Thr Thr Ile Ile Glu Gly Arg Ile Thr Ala Thr
                  45                  50                  55

 ccc aag gag agt cca aat cct cct aac ccc tct ggc cag tgc ccc atc      243
 Pro Lys Glu Ser Pro Asn Pro Pro Asn Pro Ser Gly Gln Cys Pro Ile
              60                  65                  70

 tgc cgt tgg aac ctg aag cac aag tat aac tat gac gat gtt ctg ctg      291
 Cys Arg Trp Asn Leu Lys His Lys Tyr Asn Tyr Asp Asp Val Leu Leu
          75                  80                  85

 ctt agc cag ttc atc cgg cct cat gga ggc atg ctg ccc cga aag atc      339
 Leu Ser Gln Phe Ile Arg Pro His Gly Gly Met Leu Pro Arg Lys Ile
      90                  95                 100

 aca ggc cta tgc cag gaa gaa cac cgc aag atc gag gag tgt gtg aag      387
 Thr Gly Leu Cys Gln Glu Glu His Arg Lys Ile Glu Glu Cys Val Lys
 105                 110                 115                 120

 atg gcc cac cga gca ggt cta tta cca aat cac agg cct cgg ctt cct      435
 Met Ala His Arg Ala Gly Leu Leu Pro Asn His Arg Pro Arg Leu Pro
                 125                 130                 135

 gaa gga gtt gtt ccg aag agc aaa ccc caa ctc aac cgg tac ctg acg      483
 Glu Gly Val Val Pro Lys Ser Lys Pro Gln Leu Asn Arg Tyr Leu Thr
             140                 145                 150

 cgc tgg gct cct ggc tcc gtc aag ccc atc tac aaa aaa ggc ccc cgc      531
 Arg Trp Ala Pro Gly Ser Val Lys Pro Ile Tyr Lys Lys Gly Pro Arg
         155                 160                 165

 tgg aac agg gtg cgc atg ccc gtg ggg tca ccc ctt ctg agg gac aat      579
 Trp Asn Arg Val Arg Met Pro Val Gly Ser Pro Leu Leu Arg Asp Asn
     170                 175                 180

 gtc tgc tac tca aga aca cct tgg aag ctg tat cac tga cagagagcag       628
 Val Cys Tyr Ser Arg Thr Pro Trp Lys Leu Tyr His 
 185                 190                 195

 tgcttccaga gttcctcctg cacctgtgct ggggagtagg aggcccactc acaagccctt    688

 ggccacaact atactcctgt cccaccccac cacgatggcc tggtccctcc aacatgcatg    748

 gacaggggac agtgggacta acttcagtac ccttggcctg cacagtagca atgctgggag    808

 ctagaggcag gcagggcagt tgggtccctt gccagctgct atggggctta ggccatgctc    868

 agtgctgggg acaggagttt tgcccaacgc agtgtcataa actgggttca tgggcttacc    928

 cattgggtgt gcgctcactg cttgggaagt gcagggggtc ctgggcacat tgccagctgg    988

 gtgctgagca ttgagtcact gatctcttgt gatggggcca atgagtcaat tgaattcatg   1048

 ggccaaacag gtcccatcct cttcaaaaaa aaaaaaa                            1085




      <210> 34
      <211> 481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(426)

      <400> 34
 cgcggtgacc cggctgcggt ggctgcggaa ctgacgagaa actactaaag ttcctgggga     60

 agcaaagtag aatttcat  atg aac aaa atg gat gga gag gag aaa acc tat     111
                      Met Asn Lys Met Asp Gly Glu Glu Lys Thr Tyr
                        1               5                  10

 ggt ggc tgt gaa gga cct gat gcc atg tat gtc aaa ttg ata tca tct      159
 Gly Gly Cys Glu Gly Pro Asp Ala Met Tyr Val Lys Leu Ile Ser Ser
              15                  20                  25

 gat ggc cat gaa ttt att gta aaa aga gaa cat gca tta aca tca ggc      207
 Asp Gly His Glu Phe Ile Val Lys Arg Glu His Ala Leu Thr Ser Gly
          30                  35                  40

 acg ata aaa gcc atg ttg agt ggc cca ggt cag ttt gct gag aac gaa      255
 Thr Ile Lys Ala Met Leu Ser Gly Pro Gly Gln Phe Ala Glu Asn Glu
      45                  50                  55

 acc aat gag gtc aat ttt aga gag ata cct tca cat gtg cta tcg aaa      303
 Thr Asn Glu Val Asn Phe Arg Glu Ile Pro Ser His Val Leu Ser Lys
  60                  65                  70                  75

 gta tgc atg tat ttt acg tac aag gtt cgc tac act aac agc tcc acc      351
 Val Cys Met Tyr Phe Thr Tyr Lys Val Arg Tyr Thr Asn Ser Ser Thr
                  80                  85                  90

 gag att cct gaa ttc cca att gca cct gaa att gca ctg gaa ctg ctg      399
 Glu Ile Pro Glu Phe Pro Ile Ala Pro Glu Ile Ala Leu Glu Leu Leu
              95                 100                 105

 atg gct gcg aac ttc tta gat tgt taa ataaa ataaattata ataaactgtt      451
 Met Ala Ala Asn Phe Leu Asp Cys 
         110                 115

 aactcttttc agtatttaaa aaaaaaaaaa                                     481




      <210> 35
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(528)

      <400> 35
 cagaagagtt cggcatgagg caag   atg gcg gcc tcc gtg tgc agc ggg ttg      51
                              Met Ala Ala Ser Val Cys Ser Gly Leu
                                1               5

 ctg ggg cca cgg gtg ctg tcc tgg agc cga gag ctg cct tgc gct tgg       99
 Leu Gly Pro Arg Val Leu Ser Trp Ser Arg Glu Leu Pro Cys Ala Trp
  10                  15                  20                  25

 cgc gcc ctg cac acc tcc ccg gtc tgc gcc aag aac cgg gcg gcc cga      147
 Arg Ala Leu His Thr Ser Pro Val Cys Ala Lys Asn Arg Ala Ala Arg
                  30                  35                  40

 gta cgc gta acg aag ggg gac aag ccg gtg acc tac gag gag gca cac      195
 Val Arg Val Thr Lys Gly Asp Lys Pro Val Thr Tyr Glu Glu Ala His
              45                  50                  55

 gcg ccg cac tac atc gcc cac cgt aaa ggc tgg ctg tcg ctg cac aca      243
 Ala Pro His Tyr Ile Ala His Arg Lys Gly Trp Leu Ser Leu His Thr
          60                  65                  70

 ggt aac ctg gat gga gag gac cat gcc gca gag cga acg gtg gag gat      291
 Gly Asn Leu Asp Gly Glu Asp His Ala Ala Glu Arg Thr Val Glu Asp
      75                  80                  85

 gtt ttc ctt cgc aag ttc atg tgg ggt acc ttc cca ggc tgc ctg gct      339
 Val Phe Leu Arg Lys Phe Met Trp Gly Thr Phe Pro Gly Cys Leu Ala
  90                  95                 100                 105

 gac cag ctg gtt tta aag cgc cgg ggt aac cag ttg gag atc tgt gcc      387
 Asp Gln Leu Val Leu Lys Arg Arg Gly Asn Gln Leu Glu Ile Cys Ala
                 110                 115                 120

 gtg gtc ctg agg cag ttg tct cca cac aag tac tac ttc ctc gtg ggc      435
 Val Val Leu Arg Gln Leu Ser Pro His Lys Tyr Tyr Phe Leu Val Gly
             125                 130                 135

 tac agt gaa act ttg ctg tcc tac ttt tac aaa tgt cct gtg cga ctc      483
 Tyr Ser Glu Thr Leu Leu Ser Tyr Phe Tyr Lys Cys Pro Val Arg Leu
         140                 145                 150

 cac ctc caa act gtg ccc tca aag gtt gtg tat aag tac ctc tag aac      531
 His Leu Gln Thr Val Pro Ser Lys Val Val Tyr Lys Tyr Leu 
     155                 160                 165

 aatccccttt tttccatcaa gctgtagcct gcagagaatg gaaacgtggg aaaggaatgg    591

 tatgtggggg aaatgcatcc cctcagagga ctgaggcata gtctctcatc tgctattgaa    651

 taaagacctt ctatcttaaa aaaaaaaaaa                                     681




      <210> 36
      <211> 775
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (157)..(618)

      <400> 36
 cggcacgagg ccaagatcca ggataaggaa ggcattcccc ccgaccagca gaggctcatc     60

 tttgcaggca agcagctgga agatggccgt actctttctg actacaacat ccagaaggag    120

 tcgaccctgc acctggtcct gcgtctgaga ggtggt  atg cag atc ttc gtg aag     174
                                          Met Gln Ile Phe Val Lys
                                            1               5

 acc ctg acc ggc aag acc atc acc ctg gaa gtg gag ccc agt gac acc      222
 Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr
              10                  15                  20

 atc gaa aat gtg aag gcc aag atc cag gat aaa gaa ggc atc cct ccc      270
 Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro
          25                  30                  35

 gac cag cag agg ctc atc ttt gca ggc aag cag ctg gaa gat ggc cgc      318
 Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg
      40                  45                  50

 act ctt tct gac tac aac atc cag aag gag tcg acc ctg cac ctg gtc      366
 Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val
  55                  60                  65                  70

 ctg cgt ctg aga ggt ggt atg cag atc ttc gtg aag acc ctg acc ggc      414
 Leu Arg Leu Arg Gly Gly Met Gln Ile Phe Val Lys Thr Leu Thr Gly
                  75                  80                  85

 aag acc atc act ctg gag gtg gag ccc agt gac acc atc gaa aat gtg      462
 Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val
              90                  95                 100

 aag gcc aag atc caa gat aaa gaa ggc atc ccc ccc gac cag cag agg      510
 Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg
         105                 110                 115

 ctc atc ttt gca ggc aag cag ctg gaa gat ggc cgc act ctt tct gac      558
 Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp
     120                 125                 130

 tac aac atc cag aaa gag tcg acc ctg cac ctg gtc ctg cgc ctg agg      606
 Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg
 135                 140                 145                 150

 ggt ggc tgt taa ttc ttcagtcatg gcattcgcag tgcccagtga tggcattact      661
 Gly Gly Cys 


 ctgcactata gccatttgcc ccaacttaag tttagaaatt acaagtttca gtaatagctg    721

 aacctgttca aaatgttaat aaaggtttcg ttgcatggta gcaaaaaaaa aaaa          775




      <210> 37
      <211> 1660
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (31)..(1632)

      <400> 37
 gcacgagccg acgcggcgaa ggagcgcgcc     atg gag cat gtg aca gag ggc      51
                                      Met Glu His Val Thr Glu Gly
                                        1               5

 tcc tgg gag tcg ctg cct gtg ccg ctg cac ccg cag gtg ctg ggc gcg       99
 Ser Trp Glu Ser Leu Pro Val Pro Leu His Pro Gln Val Leu Gly Ala
          10                  15                  20

 ctg cgg gag ctg ggc ttc ccg tac atg acg ccg gtg cag tcc gca acc      147
 Leu Arg Glu Leu Gly Phe Pro Tyr Met Thr Pro Val Gln Ser Ala Thr
      25                  30                  35

 atc cct ctg ttc atg cga aac aaa gat gtc gct gca gaa gcg gtc aca      195
 Ile Pro Leu Phe Met Arg Asn Lys Asp Val Ala Ala Glu Ala Val Thr
  40                  45                  50                  55

 ggt agt ggc aaa aca ctc gct ttt gtc atc ccc atc ctg gaa att ctt      243
 Gly Ser Gly Lys Thr Leu Ala Phe Val Ile Pro Ile Leu Glu Ile Leu
                  60                  65                  70

 ctg aga aga gaa gag aag tta aaa aag agt cag gtt gga gcc ata atc      291
 Leu Arg Arg Glu Glu Lys Leu Lys Lys Ser Gln Val Gly Ala Ile Ile
              75                  80                  85

 atc acc ccc act cga gag ctg gcc att caa ata gac gag gtc ctg tcg      339
 Ile Thr Pro Thr Arg Glu Leu Ala Ile Gln Ile Asp Glu Val Leu Ser
          90                  95                 100

 cat ttc acg aag cac ttc ccc gag ttc agc cag att ctt tgg atc gga      387
 His Phe Thr Lys His Phe Pro Glu Phe Ser Gln Ile Leu Trp Ile Gly
     105                 110                 115

 ggc agg aat cct gga gaa gat gtt gag agg ttt aag caa caa ggt ggg      435
 Gly Arg Asn Pro Gly Glu Asp Val Glu Arg Phe Lys Gln Gln Gly Gly
 120                 125                 130                 135

 aac atc att gtg gcc act cca ggc cgc ttg gag gac atg ttc cgg agg      483
 Asn Ile Ile Val Ala Thr Pro Gly Arg Leu Glu Asp Met Phe Arg Arg
                 140                 145                 150

 aag gcc gaa ggc ttg gat ctg gcc agc tgt gtg cga tcc ctg gat gtc      531
 Lys Ala Glu Gly Leu Asp Leu Ala Ser Cys Val Arg Ser Leu Asp Val
             155                 160                 165

 ctg gtg ttg gat gag gca gac aga ctt ctg gac atg ggg ttt gag gca      579
 Leu Val Leu Asp Glu Ala Asp Arg Leu Leu Asp Met Gly Phe Glu Ala
         170                 175                 180

 agc atc aac acc att ctg gag ttt ttg cca aag cag agg aga aca ggc      627
 Ser Ile Asn Thr Ile Leu Glu Phe Leu Pro Lys Gln Arg Arg Thr Gly
     185                 190                 195

 ctt ttc tct gcc act cag acg cag gaa gtg gag aac ctg gtg aga gcg      675
 Leu Phe Ser Ala Thr Gln Thr Gln Glu Val Glu Asn Leu Val Arg Ala
 200                 205                 210                 215

 ggc ctc cgg aac cct gtc cgg gtc tca gtg aag gag aag ggc gtg gca      723
 Gly Leu Arg Asn Pro Val Arg Val Ser Val Lys Glu Lys Gly Val Ala
                 220                 225                 230

 gcc agc agt gcc cag aag acc ccc tcc cgc ctg gaa aac tac tac atg      771
 Ala Ser Ser Ala Gln Lys Thr Pro Ser Arg Leu Glu Asn Tyr Tyr Met
             235                 240                 245

 gta tgc aag gca gat gag aaa ttt aat cag ctg gtc cat ttt ctt cgc      819
 Val Cys Lys Ala Asp Glu Lys Phe Asn Gln Leu Val His Phe Leu Arg
         250                 255                 260

 aat cat aag cag gag aaa cac ctg gtc ttc ttc agc acc tgt gcc tgt      867
 Asn His Lys Gln Glu Lys His Leu Val Phe Phe Ser Thr Cys Ala Cys
     265                 270                 275

 gtg gaa tac tat ggg aag gct ctg gaa gtg ctg gtg aag ggc gtg aag      915
 Val Glu Tyr Tyr Gly Lys Ala Leu Glu Val Leu Val Lys Gly Val Lys
 280                 285                 290                 295

 att atg tgc att cac gga aag atg aaa tat aaa cgc aat aag atc ttc      963
 Ile Met Cys Ile His Gly Lys Met Lys Tyr Lys Arg Asn Lys Ile Phe
                 300                 305                 310

 atg gag ttc cgc aaa ttg caa agt ggg att tta gtg tgc act gat gtg     1011
 Met Glu Phe Arg Lys Leu Gln Ser Gly Ile Leu Val Cys Thr Asp Val
             315                 320                 325

 atg gcc cgg gga att gat att cct gaa gtc aac tgg gtt ttg cag tat     1059
 Met Ala Arg Gly Ile Asp Ile Pro Glu Val Asn Trp Val Leu Gln Tyr
         330                 335                 340

 gac cct ccc agc aat gca agt gcc ttc gtg cat cgc tgc ggt cgc aca     1107
 Asp Pro Pro Ser Asn Ala Ser Ala Phe Val His Arg Cys Gly Arg Thr
     345                 350                 355

 gct cgc att ggc cac ggg ggc agc gct ctg gtg ttc ctc ctg ccc atg     1155
 Ala Arg Ile Gly His Gly Gly Ser Ala Leu Val Phe Leu Leu Pro Met
 360                 365                 370                 375

 gaa gag tca tac atc aat ttc ctt gca att aac caa aaa tgc ccc ctg     1203
 Glu Glu Ser Tyr Ile Asn Phe Leu Ala Ile Asn Gln Lys Cys Pro Leu
                 380                 385                 390

 cag gag atg aag ccc cag aga aac aca gcg gac ctt ctg cca aaa ctc     1251
 Gln Glu Met Lys Pro Gln Arg Asn Thr Ala Asp Leu Leu Pro Lys Leu
             395                 400                 405

 aag tcc atg gcc ctg gct gac aga gct gtg ttt gaa aag ggc atg aaa     1299
 Lys Ser Met Ala Leu Ala Asp Arg Ala Val Phe Glu Lys Gly Met Lys
         410                 415                 420

 gct ttt gtg tca tat gtc caa gct tat gca aag cat gaa tgc aac ctg     1347
 Ala Phe Val Ser Tyr Val Gln Ala Tyr Ala Lys His Glu Cys Asn Leu
     425                 430                 435

 att ttc aga tta aag gat ctt gat ttt gcc agc ctt gct cga ggt ttt     1395
 Ile Phe Arg Leu Lys Asp Leu Asp Phe Ala Ser Leu Ala Arg Gly Phe
 440                 445                 450                 455

 gcc ctg ctg agg atg ccc aag atg cca gaa ttg aga ggg aag cag ttt     1443
 Ala Leu Leu Arg Met Pro Lys Met Pro Glu Leu Arg Gly Lys Gln Phe
                 460                 465                 470

 cca gat ttt gtg ccc gtg gac gtt aat acc gac acg att cca ttt aaa     1491
 Pro Asp Phe Val Pro Val Asp Val Asn Thr Asp Thr Ile Pro Phe Lys
             475                 480                 485

 gat aaa atc aga gaa aag cag agg cag aaa ctc ctg gag caa caa aga     1539
 Asp Lys Ile Arg Glu Lys Gln Arg Gln Lys Leu Leu Glu Gln Gln Arg
         490                 495                 500

 aga gag aaa aca gaa aat gaa ggg aga aga aaa ttc ata aaa aat aaa     1587
 Arg Glu Lys Thr Glu Asn Glu Gly Arg Arg Lys Phe Ile Lys Asn Lys
     505                 510                 515

 gct tgg tca aag cag aag gcc aaa aaa aag ctg tcg ttg ttc tga gca     1635
 Ala Trp Ser Lys Gln Lys Ala Lys Lys Lys Leu Ser Leu Phe 
 520                 525                 530

 taaaagaagg tacaacgatg tatac                                         1660




      <210> 38
      <211> 2416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (764)..(2362)

      <400> 38
 taaacctctg tcacctggac cttgcttaga tattccatcg attttgtcca acaaacaatt     60

 tctggcttgg ggaggagtcc ctctaggtag aacacagctt cagaaactag ctttaagaaa    120

 taattctgca tctacaactc aacatttacg actgcttatt agaggacaag atcaggactg    180

 ctttcagctt cagaacactt ttggttcaga acagcgattg accagtaact gtgagatcag    240

 aattcaccca aaggaagaca ttttcatctc tgtattattt gcacctactc gattatcttg    300

 catgttggct agactagaaa tcaaacaact tggaaatcga tcacaaccag gcattaagtt    360

 cacaatacct ttgtctggat atggaggaac aagcaatctt attttggaag gcgttaaaaa    420

 attatctgac agttacatgg taacagtgaa tggcttagta cctggcaaag aaagtaaaat    480

 tgttttttct gtccgcaaca ctggctcccg agcagctttt gttaaagcag taggttttaa    540

 ggattctcag aaaaaagttt tgctggatcc taaagtattg aggatttttc cagataaatt    600

 tgtactcaag gaaagaacac aagaaaatgt tactttaata tataatccat cagacagagg    660

 aatcaataat aaaactgcaa cagaactatc aactgtatac ttatttggtg gagatgaaat    720

 ttcaagacag cagtatcgca gggccctgtt acataaacca gag  atg ata aaa cag     775
                                                  Met Ile Lys Gln
                                                    1

 ata ctt cca gaa cat agt gtg ctt caa aac att aat ttt gtt gaa gca      823
 Ile Leu Pro Glu His Ser Val Leu Gln Asn Ile Asn Phe Val Glu Ala
   5                  10                  15                  20

 ttt caa gat gag cta tta gta act gaa gta tat gat ctt ccc caa cga      871
 Phe Gln Asp Glu Leu Leu Val Thr Glu Val Tyr Asp Leu Pro Gln Arg
                  25                  30                  35

 cct aat gat gtt cag ctc ttt tat gga agc atg tgt aaa att ata ctt      919
 Pro Asn Asp Val Gln Leu Phe Tyr Gly Ser Met Cys Lys Ile Ile Leu
              40                  45                  50

 tca gta att gga gaa ttc aga gat tgc att tct agc aga gaa ttc ctt      967
 Ser Val Ile Gly Glu Phe Arg Asp Cys Ile Ser Ser Arg Glu Phe Leu
          55                  60                  65

 cag cct tct tcc aaa gct agc ttg gaa tct aca agc gac ttg gga gct     1015
 Gln Pro Ser Ser Lys Ala Ser Leu Glu Ser Thr Ser Asp Leu Gly Ala
      70                  75                  80

 tct ggg aaa cat ggt ggc aac gtc tct ttg gat gtt tta cca gtc aaa     1063
 Ser Gly Lys His Gly Gly Asn Val Ser Leu Asp Val Leu Pro Val Lys
  85                  90                  95                 100

 ggt cct cag ggt tct cct ctt ctc tca cgg gcg gct cgc ccg cct ccg     1111
 Gly Pro Gln Gly Ser Pro Leu Leu Ser Arg Ala Ala Arg Pro Pro Pro
                 105                 110                 115

 gat cag ctg gcc tcc gaa gag ccg tgg act gtc cta ccc gag cac ttg     1159
 Asp Gln Leu Ala Ser Glu Glu Pro Trp Thr Val Leu Pro Glu His Leu
             120                 125                 130

 att ctg gta gct cct tct cct tgt gac atg gca aaa act gga cgt ttc     1207
 Ile Leu Val Ala Pro Ser Pro Cys Asp Met Ala Lys Thr Gly Arg Phe
         135                 140                 145

 cag att gtg aat aac tct gtg agg tta ctg aga ttt gag ctg tgc tgg     1255
 Gln Ile Val Asn Asn Ser Val Arg Leu Leu Arg Phe Glu Leu Cys Trp
     150                 155                 160

 cca gcg cat tgc ctc aca gtc acg ccg cag cat gga tgt gtc gcg cca     1303
 Pro Ala His Cys Leu Thr Val Thr Pro Gln His Gly Cys Val Ala Pro
 165                 170                 175                 180

 gag agt aaa cta caa att ctt gtg agt cct aat tcc tcc tta tcc aca     1351
 Glu Ser Lys Leu Gln Ile Leu Val Ser Pro Asn Ser Ser Leu Ser Thr
                 185                 190                 195

 aaa cag tca atg ttc ccg tgg agt ggt ttg atc tat ata cac tgt gac     1399
 Lys Gln Ser Met Phe Pro Trp Ser Gly Leu Ile Tyr Ile His Cys Asp
             200                 205                 210

 gat gga cag aag aaa att gtg aaa gtt caa att cga gaa gat tta act     1447
 Asp Gly Gln Lys Lys Ile Val Lys Val Gln Ile Arg Glu Asp Leu Thr
         215                 220                 225

 caa gtg gaa ctt tta act cgt ttg acc tcc aaa cca ttt gga att ctt     1495
 Gln Val Glu Leu Leu Thr Arg Leu Thr Ser Lys Pro Phe Gly Ile Leu
     230                 235                 240

 tcc cca gta tct gag cct tca gtt agt cat ttg gtc aaa cca atg aca     1543
 Ser Pro Val Ser Glu Pro Ser Val Ser His Leu Val Lys Pro Met Thr
 245                 250                 255                 260

 aaa ccg cct tcc aca aaa gtt gaa ata aga aac aag agt att act ttt     1591
 Lys Pro Pro Ser Thr Lys Val Glu Ile Arg Asn Lys Ser Ile Thr Phe
                 265                 270                 275

 cct aca aca gaa cct ggt gaa act tca gag agc tgt cta gaa ctc gag     1639
 Pro Thr Thr Glu Pro Gly Glu Thr Ser Glu Ser Cys Leu Glu Leu Glu
             280                 285                 290

 aat cat ggc acc aca gac gtg aaa tgg cat ctg tca tct tta gcg cca     1687
 Asn His Gly Thr Thr Asp Val Lys Trp His Leu Ser Ser Leu Ala Pro
         295                 300                 305

 cct tat gtc aag gga gtt gat gaa agt gga gat gtt ttt aga gct acc     1735
 Pro Tyr Val Lys Gly Val Asp Glu Ser Gly Asp Val Phe Arg Ala Thr
     310                 315                 320

 tat gca gca ttc aga tgt tct cct att tct ggt ctg ctg gaa agc cat     1783
 Tyr Ala Ala Phe Arg Cys Ser Pro Ile Ser Gly Leu Leu Glu Ser His
 325                 330                 335                 340

 ggg atc caa aaa gtc tcc atc aca ttt ttg ccc aga ggt agg ggg gat     1831
 Gly Ile Gln Lys Val Ser Ile Thr Phe Leu Pro Arg Gly Arg Gly Asp
                 345                 350                 355

 tat gcc cag ttt tgg gat gtt gaa tgt cac cct ctt aag gag cct cac     1879
 Tyr Ala Gln Phe Trp Asp Val Glu Cys His Pro Leu Lys Glu Pro His
             360                 365                 370

 atg aaa cac acg ttg aga ttc caa ctc tct gga caa agc atc gaa gca     1927
 Met Lys His Thr Leu Arg Phe Gln Leu Ser Gly Gln Ser Ile Glu Ala
         375                 380                 385

 gaa aat gag cct gaa aac gca tgc ctt tcc acg gat tcc ctc att aaa     1975
 Glu Asn Glu Pro Glu Asn Ala Cys Leu Ser Thr Asp Ser Leu Ile Lys
     390                 395                 400

 ata gat cat tta gtt aag ccc cga aga caa gct gtg tca gag gct tct     2023
 Ile Asp His Leu Val Lys Pro Arg Arg Gln Ala Val Ser Glu Ala Ser
 405                 410                 415                 420

 gct cgc ata cct gag cag ctt gat gtg act gct cgt gga gtt tat gcc     2071
 Ala Arg Ile Pro Glu Gln Leu Asp Val Thr Ala Arg Gly Val Tyr Ala
                 425                 430                 435

 cca gag gat gtg tac agg ttc ctg ccg act agt gtg ggg gaa tca cgg     2119
 Pro Glu Asp Val Tyr Arg Phe Leu Pro Thr Ser Val Gly Glu Ser Arg
             440                 445                 450

 aca ctt aaa gtc aat ctg cga aat aat tct ttt att aca cac tca ctg     2167
 Thr Leu Lys Val Asn Leu Arg Asn Asn Ser Phe Ile Thr His Ser Leu
         455                 460                 465

 aag ttt ttg agt ccc aga gag cca ttc tat gtc aaa cat tcc aag tac     2215
 Lys Phe Leu Ser Pro Arg Glu Pro Phe Tyr Val Lys His Ser Lys Tyr
     470                 475                 480

 tct ttg aga gcc cag cat tac atc aac atg ccc gtg cag ttc aaa ccg     2263
 Ser Leu Arg Ala Gln His Tyr Ile Asn Met Pro Val Gln Phe Lys Pro
 485                 490                 495                 500

 aag tcc gca ggc aaa ttt gaa gct ttg ctt gtc att caa aca gat gaa     2311
 Lys Ser Ala Gly Lys Phe Glu Ala Leu Leu Val Ile Gln Thr Asp Glu
                 505                 510                 515

 ggc aag agt att gct att cga cta att ggt gaa gct ctt gga aaa aat     2359
 Gly Lys Ser Ile Ala Ile Arg Leu Ile Gly Glu Ala Leu Gly Lys Asn
             520                 525                 530

 taa ctag aatacatttt tgtgtaaagt aaattacata agttgtattt tgttaacttt     2416
 






      <210> 39
      <211> 2742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(1406)

      <400> 39
 tgtcgttgtt ctgaggcttc accgtgcccc tgcccgcgac c    atg gcc tcc tcc      53
                                                  Met Ala Ser Ser
                                                    1

 gag gtg gcg cgg cac ctg ctc ttt cag tct cac atg gca acg aaa aca      101
 Glu Val Ala Arg His Leu Leu Phe Gln Ser His Met Ala Thr Lys Thr
   5                  10                  15                  20

 act tgt atg tct tca caa gga tca gat gat gaa cag ata aaa aga gaa      149
 Thr Cys Met Ser Ser Gln Gly Ser Asp Asp Glu Gln Ile Lys Arg Glu
                  25                  30                  35

 aac att cgt tcg ttg act atg tct ggc cat gtt ggt ttt gag agt ttg      197
 Asn Ile Arg Ser Leu Thr Met Ser Gly His Val Gly Phe Glu Ser Leu
              40                  45                  50

 cct gat cag ctg gtg aac aga tcc att cag caa ggt ttc tgc ttt aat      245
 Pro Asp Gln Leu Val Asn Arg Ser Ile Gln Gln Gly Phe Cys Phe Asn
          55                  60                  65

 att ctc tgt gtg ggg gaa act gga att gga aaa tca aca ctg att gac      293
 Ile Leu Cys Val Gly Glu Thr Gly Ile Gly Lys Ser Thr Leu Ile Asp
      70                  75                  80

 aca ttg ttt aat act aat ttt gaa gac tat gaa tcc tca cat ttt tgc      341
 Thr Leu Phe Asn Thr Asn Phe Glu Asp Tyr Glu Ser Ser His Phe Cys
  85                  90                  95                 100

 cca aat gtt aaa ctt aaa gct cag aca tat gaa ctc cag gaa agt aat      389
 Pro Asn Val Lys Leu Lys Ala Gln Thr Tyr Glu Leu Gln Glu Ser Asn
                 105                 110                 115

 gtt caa ttg aaa ttg acc att gtg aat aca gtg gga ttt ggt gac caa      437
 Val Gln Leu Lys Leu Thr Ile Val Asn Thr Val Gly Phe Gly Asp Gln
             120                 125                 130

 ata aat aaa gaa gag agc tac caa cca ata gtt gac tac ata gat gct      485
 Ile Asn Lys Glu Glu Ser Tyr Gln Pro Ile Val Asp Tyr Ile Asp Ala
         135                 140                 145

 cag ttt gag gcc tat ctc caa gaa gaa ctg aag att aag cgt tct ctc      533
 Gln Phe Glu Ala Tyr Leu Gln Glu Glu Leu Lys Ile Lys Arg Ser Leu
     150                 155                 160

 ttt acc tac cat gat tct cgc atc cat gtg tgt ctc tac ttc att tca      581
 Phe Thr Tyr His Asp Ser Arg Ile His Val Cys Leu Tyr Phe Ile Ser
 165                 170                 175                 180

 ccg aca ggc cac tct ctg aag aca ctt gat ctc tta acc atg aag aac      629
 Pro Thr Gly His Ser Leu Lys Thr Leu Asp Leu Leu Thr Met Lys Asn
                 185                 190                 195

 ctt gac agc aag gta aac att ata cca gtg att gcc aaa gca gat acg      677
 Leu Asp Ser Lys Val Asn Ile Ile Pro Val Ile Ala Lys Ala Asp Thr
             200                 205                 210

 gtt tct aaa act gaa tta cag aag ttt aag atc aag ctc atg agt gaa      725
 Val Ser Lys Thr Glu Leu Gln Lys Phe Lys Ile Lys Leu Met Ser Glu
         215                 220                 225

 ttg gtc agc aat ggc gtc cag ata tac cag ttc cca acg gat gat gac      773
 Leu Val Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Asp Asp
     230                 235                 240

 act att gct aag gtc aac gct gca atg aat gga cag ttg ccg ttt gct      821
 Thr Ile Ala Lys Val Asn Ala Ala Met Asn Gly Gln Leu Pro Phe Ala
 245                 250                 255                 260

 gtt gtg gga agt atg gat gag gta aaa gtc gga aac aag atg gtc aaa      869
 Val Val Gly Ser Met Asp Glu Val Lys Val Gly Asn Lys Met Val Lys
                 265                 270                 275

 gct cgc cag tac cct tgg ggt gtt gta caa gtg gaa aat gaa aac cac      917
 Ala Arg Gln Tyr Pro Trp Gly Val Val Gln Val Glu Asn Glu Asn His
             280                 285                 290

 tgt gac ttt gta aag ctg cgg gaa atg ctc att tgt aca aat atg gag      965
 Cys Asp Phe Val Lys Leu Arg Glu Met Leu Ile Cys Thr Asn Met Glu
         295                 300                 305

 gac ctg cga gag cag acc cat acc agg cac tat gag ctt tac agg cgc     1013
 Asp Leu Arg Glu Gln Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg
     310                 315                 320

 tgc aaa ctg gag gaa atg ggc ttt aca gat gtg ggc cca gaa aac aag     1061
 Cys Lys Leu Glu Glu Met Gly Phe Thr Asp Val Gly Pro Glu Asn Lys
 325                 330                 335                 340

 cca gtc agt gtt caa gag acc tat gaa gcc aaa aga cat gag ttc cat     1109
 Pro Val Ser Val Gln Glu Thr Tyr Glu Ala Lys Arg His Glu Phe His
                 345                 350                 355

 ggt gaa cgt cag agg aag gaa gaa gaa atg aaa cag atg ttt gtg cag     1157
 Gly Glu Arg Gln Arg Lys Glu Glu Glu Met Lys Gln Met Phe Val Gln
             360                 365                 370

 cga gta aag gag aaa gaa gcc ata ttg aaa gaa gct gag aga gag cta     1205
 Arg Val Lys Glu Lys Glu Ala Ile Leu Lys Glu Ala Glu Arg Glu Leu
         375                 380                 385

 cag gcc aaa ttt gag cac ctt aag aga ctt cac caa gaa gag aga atg     1253
 Gln Ala Lys Phe Glu His Leu Lys Arg Leu His Gln Glu Glu Arg Met
     390                 395                 400

 aag ctt gaa gaa aag aga aga ctt ttg gaa gaa gaa ata att gct ttc     1301
 Lys Leu Glu Glu Lys Arg Arg Leu Leu Glu Glu Glu Ile Ile Ala Phe
 405                 410                 415                 420

 tct aaa aag aaa gct acc tcc gag ata ttt cac agc cag tcc ttt ctg     1349
 Ser Lys Lys Lys Ala Thr Ser Glu Ile Phe His Ser Gln Ser Phe Leu
                 425                 430                 435

 gca aca ggc agc aac ctg agg aag gac aag gac cgt aag aac tcc aat     1397
 Ala Thr Gly Ser Asn Leu Arg Lys Asp Lys Asp Arg Lys Asn Ser Asn
             440                 445                 450

 ttt ttg taa aacagaa gttccagagc acagaaggtc atcatcacaa gcaaacttta     1453
 Phe Leu 


 ttaaaaaaaa actagaagtg tgctttgatt ttgctgttat ttgttttatc acttctatat   1513

 ttggtgaaca gccacagtta ctgatattta tggaaaagta ctttcaagta caaggtcaat   1573

 acataagcca gagtgaatga tactacaagt tgagcatctc taattcaaaa atctgaaatc   1633

 cagaagcttc aaaatctgaa tctttttgag cactgacttg accccacaag tggaaaattc   1693

 cccacccgac acctttgctt tctgatggtt cagtttaaac agattttgtt tcttgcacaa   1753

 aatttttgta taaattactt tcaggctata tgtataaggt ggatgtgaaa catgaattat   1813

 gtaattagag tcgggtcccg ttgtgtatat gcagatattc caaacctgaa atccaaaaca   1873

 cttctggtcc ctagcatttt ggataaggga tactcagctt gtacctatat attcatatat   1933

 attcactgtt gttagaaatg tttaagttgc tgttctgtga tgaatctaaa tcttttctct   1993

 tgctaccaag ctattgtcac tgcagtgcat tataccaaag agcgaagtca gtgccactga   2053

 aaatacagaa cccattaata tcgtggctat ctgattacat ttatattcca agatgaacct   2113

 tttttatata tgctaaaaat tttggggaat atgttttggg atgtattatg gagctaaaac   2173

 tctaacctct taatagtttt atagaactta aaaatttttt atacaattac ccaattggtg   2233

 atatgatctt aagcttttgt gtcagattat ttaatatgat gacttcatgc tttattatgc   2293

 cttattatgg ctgacgtatt actgtggtga aacaaaatat ctttaaaagt taaaacatcc   2353

 agatatataa gctatttttt cctaaggata aagtaccttt gagcatgagt gtatcacagc   2413

 tttcattagg aaaacttttc attacatact tgtttaaact ctgtcttcca gggtaaaaat   2473

 aataaggttg aatcatttta ttaaaaatac tttttaagaa aataactatg aacatctgaa   2533

 tattaaagat ataaaaatgc acataattca tatttcaggt ggtatttgca ttcagtgcct   2593

 tactggtatt ctcagaacat tttaatgatt tctaacattt cttaacagtc atagatatat   2653

 acattttcat tttttgtact tgaatattct aaataaaact gacatttact cttgacaaat   2713

 aaaacatata tttactaaaa aaaaaaaaa                                     2742




      <210> 40
      <211> 2548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (372)..(2498)

      <400> 40
 gtgatggcct ccctgaaatt aaacatttct attagtggct tcccgttaat ctcatccttc     60

 ttagatcaaa cctcgttata tctcctgcct atctcttttg cattccaaag ttcagtttta    120

 ttaaatccca gggtctaaga ttttttcttt gagaatttat ctccagtgtt tctatggaaa    180

 ttaaaaaaga aaattaggat aattcaatgt cgaaatgttg catgcatctt ttgagaaatt    240

 tatattttgt aggttgaagg acttgctttt tgggcagcgt atttttggag gtggaatgta    300

 gttattttaa taaccatgtc ctaattattt atagcttcct gcctgacaca gctcacttca    360

 agaagtgcac a atg tca gaa cgt gga att aag tgg gct tgt gaa tat tgt     410
              Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys
                1               5                  10

 acg tat gaa aac tgg cca tct gca atc aag tgt act atg tgt cgt gcc      458
 Thr Tyr Glu Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala
      15                  20                  25

 caa aga cct agt gga aca att att aca gaa gat cca ttt aaa agt ggt      506
 Gln Arg Pro Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly
  30                  35                  40                  45

 tca agt gat gtt ggt aga gat tgg gat cct tcc agc acc gaa gga gga      554
 Ser Ser Asp Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly
                  50                  55                  60

 agt agt cct ttg ata tgt cca gac tct agt gca aga cca agg gtg aaa      602
 Ser Ser Pro Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys
              65                  70                  75

 tct tcg tat agc atg gaa aat gca aat aag tgg tca tgc cac atg tgt      650
 Ser Ser Tyr Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys
          80                  85                  90

 aca tat ttg aac tgg cca aga gca atc aga tgt acc cag tgc tta tcc      698
 Thr Tyr Leu Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser
      95                 100                 105

 caa cgt agg acc agg agt cct aca gaa tct cct cag tcc tca gga tct      746
 Gln Arg Arg Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser
 110                 115                 120                 125

 ggc tca aga cca gtt gct ttt tct gtt gat cct tgt gag gaa tac aat      794
 Gly Ser Arg Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn
                 130                 135                 140

 gat aga aat aaa ctg aac act agg aca cag cac tgg act tgc tct gtt      842
 Asp Arg Asn Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val
             145                 150                 155

 tgc aca tat gaa aac tgg gcc aag gct aaa aga tgt gtt gtt tgt gat      890
 Cys Thr Tyr Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp
         160                 165                 170

 cat ccc aga cct aat aac att gaa gca ata gaa ttg gca gag act gaa      938
 His Pro Arg Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu
     175                 180                 185

 gag gct tct tca ata ata aat gag caa gac aga gct cga tgg agg gga      986
 Glu Ala Ser Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly
 190                 195                 200                 205

 agt tgc agt agt ggt aat agc caa agg aga tca cct cct gct acg aag     1034
 Ser Cys Ser Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys
                 210                 215                 220

 cgg gac tct gaa gtg aaa atg gat ttt cag agg att gaa ttg gct ggt     1082
 Arg Asp Ser Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly
             225                 230                 235

 gct gtg gga agc aag gag gaa ctt gaa gta gac ttt aaa aaa cta aag     1130
 Ala Val Gly Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys
         240                 245                 250

 caa att aaa aac agg atg aaa aag act gat tgg ctc ttc ctc aat gct     1178
 Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala
     255                 260                 265

 tgt gtg ggg gtt gta gaa ggt gat tta gct gcc ata gaa gca tac aag     1226
 Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys
 270                 275                 280                 285

 tca tca gga gga gac att gca cgt cag ctc acc gca gat gaa gta cgc     1274
 Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg
                 290                 295                 300

 ttg ctg aat cgt cct tct gcc ttt gat gtt ggc tat act ctt gta cac     1322
 Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His
             305                 310                 315

 ttg gct ata cgt ttt cag agg cag gat atg cta gca ata ttg ctt aca     1370
 Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr
         320                 325                 330

 gag gtg tct caa caa gca gca aag tgt att cca gca atg gtg tgt cct     1418
 Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro
     335                 340                 345

 gaa ctg aca gaa caa atc cgg aga gag ata gct gcc tct ctt cat cag     1466
 Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln
 350                 355                 360                 365

 aga aag ggg gat ttt gct tgc tat att ctg act gac ctg gta aca ttt     1514
 Arg Lys Gly Asp Phe Ala Cys Tyr Ile Leu Thr Asp Leu Val Thr Phe
                 370                 375                 380

 aca ttg gca gca gat att gaa gat ttg ccc cca aca gtc caa gaa aaa     1562
 Thr Leu Ala Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys
             385                 390                 395

 tta ttt gat gag gtg ctt gat aga gac gtt caa aaa gaa tta gaa gaa     1610
 Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu
         400                 405                 410

 gaa tct cca att att aac tgg tcc ttg gaa ttg gct aca cgt ttg gac     1658
 Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp
     415                 420                 425

 agt cga ctg tat gca ctt tgg aac cgg act gca gga gac tgc cta ctt     1706
 Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu
 430                 435                 440                 445

 gat tca gtt cta caa gct acc tgg ggc atc tat gac aag gac tca gtg     1754
 Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val
                 450                 455                 460

 ctt cgg aaa gcc ctg cat gac agc ctg cat gac tgt tca cat tgg ttt     1802
 Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe
             465                 470                 475

 tac aca cgc tgg aaa gat tgg gaa tca tgg tat tct cag agc ttt ggt     1850
 Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly
         480                 485                 490

 tta cat ttt tcc ttg aga gaa gaa caa tgg caa gaa gac tgg gca ttt     1898
 Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe
     495                 500                 505

 ata ctc tct ctt gct agt cag cct gga gca agc ttg gag cag acg cac     1946
 Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His
 510                 515                 520                 525

 att ttt gta ctg gca cat att ctt aga cga cca att ata gtt tat gga     1994
 Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly
                 530                 535                 540

 gta aaa tat tac aag agt ttc cgg gga gaa act tta gga tat act cgg     2042
 Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg
             545                 550                 555

 ttt caa ggt gtt tat ctg cct ttg ttg tgg gaa cag agt ttt tgt tgg     2090
 Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp
         560                 565                 570

 aaa agt ccg att gct ctg ggt tat acg agg ggc cac ttc tct gct ttg     2138
 Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu
     575                 580                 585

 gtt gcc atg gaa aat gat ggc tat ggc aac cga ggt gct ggt gct aat     2186
 Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn
 590                 595                 600                 605

 ctc aat acc gat gat gat gtc acc atc aca ttt ttg cct ctg gtt gac     2234
 Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp
                 610                 615                 620

 agt gaa agg aag cta ctc cat gtg cac ttc ctt tct gct cag gag cta     2282
 Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu
             625                 630                 635

 ggt aat gag gaa cag caa gaa aaa ctg ctc agg gag tgg ctg gac tgc     2330
 Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys
         640                 645                 650

 tgt gtg acg gag ggg gga gtt ctg gtt gcc atg cag aag agt tct cgg     2378
 Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg
     655                 660                 665

 cgg cga aat cac ccc ctg gtc act cag atg gta gaa aaa tgg ctt gac     2426
 Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp
 670                 675                 680                 685

 cgc tac cga cag atc cgg ccg tgt aca tcc ctg tct gat gga gag gaa     2474
 Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser Asp Gly Glu Glu
                 690                 695                 700

 gat gag gat gat gaa gat gaa tga aaaaaaaaat caaacagcag aagaccaagg    2528
 Asp Glu Asp Asp Glu Asp Glu 
             705

 catcagatct gtaatgaccc                                               2548




      <210> 41
      <211> 1305
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (749)..(1060)

      <400> 41
 gcagcactga ttgcttctga cctgcaggag gcatgggagc ggccccgccg gccctttcaa     60

 ggcagctgct ggtatgtaga tttgtctccg ctcagtgatg agggattttt tggtcttcct    120

 tttggcttta tttttaaact gctttagata ctactgctca gtgtttgtga actttcctag    180

 ttctctgatg ttcagttgat gcagccagca cccagtgggg acctattagg aaaagaaact    240

 ggcatgtgca tgtgcccagc aggaagcttc atctccacgt cagctgctgc catccaggga    300

 aggccctgga gcctcacgca gtcgaggctg ctctcaggtg ctacgtgttg ccagtggtgg    360

 cacccgttgt cctgccgagc ccagggcgtt ctgttccggg cgagccttgt gctgcagggg    420

 catcagcatg caggctgccc cgggagggtc caggtgctgc aggcagagtt caacgtgggg    480

 cttgtccgcc ctcccttagc tctggctcag tgcatcctac tgtggggaca tctcatgagg    540

 ggacacgaag tcactgatct cactcccagt atttggagct gggaacccaa atagtgtggc    600

 gcaggactga tctgtgcctg ttattttggt tgtgagtcat tgtcctgtgg aattggcaaa    660

 agctacattt ttactgtcct taccagcaac ggttcgtgtt gtcacatgct gtgagtgcag    720

 gctgtggtgt gtccttgtgt gtacatgt   atg tat atg tat aca tca tgc aca     772
                                  Met Tyr Met Tyr Thr Ser Cys Thr
                                    1               5

 aag cat gtc atg ctg ctg tcc agc ggt gaa gca aca agt aca ata aaa      820
 Lys His Val Met Leu Leu Ser Ser Gly Glu Ala Thr Ser Thr Ile Lys
      10                  15                  20

 tgt ggc tct aaa acg gct tct gat ttc ttg aca agt cag gca ggg acc      868
 Cys Gly Ser Lys Thr Ala Ser Asp Phe Leu Thr Ser Gln Ala Gly Thr
  25                  30                  35                  40

 ttc agg agc ttt cct agc agg tgc aca gaa gga acc act gag ccc aca      916
 Phe Arg Ser Phe Pro Ser Arg Cys Thr Glu Gly Thr Thr Glu Pro Thr
                  45                  50                  55

 gtg tgc aga gtg tgt gtg ccc agg gca ctg cca tgg ccc cca ccg gca      964
 Val Cys Arg Val Cys Val Pro Arg Ala Leu Pro Trp Pro Pro Pro Ala
              60                  65                  70

 ctg gcc tct ggt ctg cag agt cag gtg ccc atc ctg ggg gct ctg tca     1012
 Leu Ala Ser Gly Leu Gln Ser Gln Val Pro Ile Leu Gly Ala Leu Ser
          75                  80                  85

 tgc tca cct gac cca ggt gtg tgt ccc ggt gtg aaa tct agg agg tga     1060
 Cys Ser Pro Asp Pro Gly Val Cys Pro Gly Val Lys Ser Arg Arg 
      90                  95                 100

 ctggaaaccc tttcctcact tgaaacatta aagacgattt tctaagcaac agatacaaac   1120

 agtggcaaag ctgcatctga agaggagccc aggaaggggc cctgtcctgg ccccagagga   1180

 gtccacacag caccaccctc cagaagtggc tgggcccggg gtcttgcagg cggcaccttt   1240

 tggtagattt tgtttcccta gaaaatgggg aaaatatttc aagccacgaa atcgtcgaca   1300

 gcgaa                                                               1305




      <210> 42
      <211> 1585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(914)

      <400> 42
 cgcgtacgta tgcttggatc ctctagagcg gccgctgtcg ttgttctgag gggccgggcc     60

 ggcggagcgc gcagcggggg ctgcagattc tttccacc    atg gcc aga cgc ccc     113
                                              Met Ala Arg Arg Pro
                                                1               5

 cgg aac agc agg gcc tgg cac ttc gtc ctg agt gca gcc cgc cga gac      161
 Arg Asn Ser Arg Ala Trp His Phe Val Leu Ser Ala Ala Arg Arg Asp
                  10                  15                  20

 gca gat gcc cgg gcc gtg gct cta gca ggc tcc act aac tgg ggc tac      209
 Ala Asp Ala Arg Ala Val Ala Leu Ala Gly Ser Thr Asn Trp Gly Tyr
              25                  30                  35

 gac tct gat ggg cag cac agc gac tcg gac tcc gac ccc gag tac tcc      257
 Asp Ser Asp Gly Gln His Ser Asp Ser Asp Ser Asp Pro Glu Tyr Ser
          40                  45                  50

 acg ctg ccg cca tcc atc ccc agt gcg gtg ccc gtg acc ggc gag tcc      305
 Thr Leu Pro Pro Ser Ile Pro Ser Ala Val Pro Val Thr Gly Glu Ser
      55                  60                  65

 ttc tgt gac tgt gct ggg cag agc gag gcc tcc ttc tgt agc agc ctg      353
 Phe Cys Asp Cys Ala Gly Gln Ser Glu Ala Ser Phe Cys Ser Ser Leu
  70                  75                  80                  85

 cac tcg gcc cac cgg ggc agg gac tgc cgc tgc gga gag gaa gac gag      401
 His Ser Ala His Arg Gly Arg Asp Cys Arg Cys Gly Glu Glu Asp Glu
                  90                  95                 100

 tat ttc gac tgg gtc tgg gat gac tta aat aag tca tca gcc acc ctg      449
 Tyr Phe Asp Trp Val Trp Asp Asp Leu Asn Lys Ser Ser Ala Thr Leu
             105                 110                 115

 ctg agc tgt gac aac cgt aag gtc agc ttc cac atg gag tac agc tgc      497
 Leu Ser Cys Asp Asn Arg Lys Val Ser Phe His Met Glu Tyr Ser Cys
         120                 125                 130

 ggc aca gcg gcc atc cgg ggc acc aag gag ctg ggg gag ggc cag cac      545
 Gly Thr Ala Ala Ile Arg Gly Thr Lys Glu Leu Gly Glu Gly Gln His
     135                 140                 145

 ttc tgg gag atc aag atg acc tct ccc gtc tac ggc acc gac atg atg      593
 Phe Trp Glu Ile Lys Met Thr Ser Pro Val Tyr Gly Thr Asp Met Met
 150                 155                 160                 165

 gtg ggc atc ggg acg tcg gat gtg gac ctg gac aaa tac cgc cac acg      641
 Val Gly Ile Gly Thr Ser Asp Val Asp Leu Asp Lys Tyr Arg His Thr
                 170                 175                 180

 ttc tgc agc ctg ctg ggc agg gat gag gac agc tgg ggc ctc tcc tac      689
 Phe Cys Ser Leu Leu Gly Arg Asp Glu Asp Ser Trp Gly Leu Ser Tyr
             185                 190                 195

 acg ggc ctc ctc cac cac aag ggc gac aag acc agc ttc tcg tcg cgg      737
 Thr Gly Leu Leu His His Lys Gly Asp Lys Thr Ser Phe Ser Ser Arg
         200                 205                 210

 ttc ggc cag ggc tcc atc att ggc gtg cac ctg gac acc tgg cac ggc      785
 Phe Gly Gln Gly Ser Ile Ile Gly Val His Leu Asp Thr Trp His Gly
     215                 220                 225

 aca ctc acc ttt ttc aag aac agg aag tgt ata ggc tgg gcc cct ccc      833
 Thr Leu Thr Phe Phe Lys Asn Arg Lys Cys Ile Gly Trp Ala Pro Pro
 230                 235                 240                 245

 ttc cag gtg tgg cag cca cca agc tgc aga aca aga gat tct acc cga      881
 Phe Gln Val Trp Gln Pro Pro Ser Cys Arg Thr Arg Asp Ser Thr Arg
                 250                 255                 260

 tgg tgt gct cca cgg cgg ccc gga gca gca tga aggtcacc cgctcctgtg      932
 Trp Cys Ala Pro Arg Arg Pro Gly Ala Ala 
             265                 270

 ccagcgccac ttccctccag tacctgtgct gccaccgcct gcgccagctg cggccagact    992

 cgggagacac gctggagggt ctgccgctgc cgccgggcct caagcaggtg ctacacaaca   1052

 agctgggctg ggtcctgagc atgagttgca gccgccgcaa ggctccagtg tccgatcccc   1112

 aggcagcgac ctccgcccac cccagcagtc gcgagcctcg gccctgccag aggaagcgct   1172

 gccgccggac ctgactgact tcccagtgga actgccttct tgggctggga cagccccttt   1232

 cctctgtccc ttctttctct gtcccttcct tccagccaca ctccagggcg gagttggatg   1292

 aggcccgtcc ggagggagcc atctcttgct cccgaggctg ggacagtcct ttctgtgggg   1352

 gctctagggc ccctctgctg ctgtgctggg tggggaagcg gctgccctga gccccaggtc   1412

 ttgtgggagg ctgcgaggac gagagcctgg ctggagcccg cgttgctgtt cccacagggc   1472

 ctcggttttt cctaacttgc tctgcatgct gtcagcggct gccccgccgt catagactta   1532

 aaggactgca ataaatgtag agttgatgtc taacacccac aaaaaaaaaa aaa          1585




      <210> 43
      <211> 1909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(450)

      <400> 43
 tggcgggcga gcggctggga cggg   atg gga ttc ttc tca cgg cgc acg ttc      51
                              Met Gly Phe Phe Ser Arg Arg Thr Phe
                                1               5

 tgt ggg cgg agt ggg cgg agc tgc cgg ggt cag ttg gtc caa gtg tcc       99
 Cys Gly Arg Ser Gly Arg Ser Cys Arg Gly Gln Leu Val Gln Val Ser
  10                  15                  20                  25

 cgg cct gag gtg tcg gcc gga tcc ctc ctt ctc ccg gcg cct caa gcg      147
 Arg Pro Glu Val Ser Ala Gly Ser Leu Leu Leu Pro Ala Pro Gln Ala
                  30                  35                  40

 gaa gac cat tcc tca aga att ttg tat cca agg ccc aaa agt ttg tta      195
 Glu Asp His Ser Ser Arg Ile Leu Tyr Pro Arg Pro Lys Ser Leu Leu
              45                  50                  55

 ccc aag atg atg aat gct gac atg gat gca gtt gat gct gaa aat caa      243
 Pro Lys Met Met Asn Ala Asp Met Asp Ala Val Asp Ala Glu Asn Gln
          60                  65                  70

 gtg gaa ctg gag gaa aaa aca aga ctt att aat caa gtg ttg gaa ctc      291
 Val Glu Leu Glu Glu Lys Thr Arg Leu Ile Asn Gln Val Leu Glu Leu
      75                  80                  85

 caa cac aca ctt gaa gat ctc tct gca aga gta gat gca gtt aag gaa      339
 Gln His Thr Leu Glu Asp Leu Ser Ala Arg Val Asp Ala Val Lys Glu
  90                  95                 100                 105

 gaa aat ctg aag cta aaa tca gaa aac caa gtt ctt gga caa tat ata      387
 Glu Asn Leu Lys Leu Lys Ser Glu Asn Gln Val Leu Gly Gln Tyr Ile
                 110                 115                 120

 gaa aat ctc atg tca gct tct agt gtt ttt caa aca act gac aca aaa      435
 Glu Asn Leu Met Ser Ala Ser Ser Val Phe Gln Thr Thr Asp Thr Lys
             125                 130                 135

 agc aaa aga aag taa gggattgaca cccttctgtt ttatggaatt gctgctgatc      490
 Ser Lys Arg Lys 
         140

 attttttctt taaaacttgg atagattcca aaagttacag tacctttgtg gcttcattga    550

 atatttatga agataatgtc agatgtagac aaaaataaca caataacagg agacttccat    610

 aagtttgtgt attatgttag tctatgaaaa cgtgcaaatg tattgtagag actttatgat    670

 tagaattgca tatatttatg aaacttaaag atgaatgttt tattgaattt gtaggtttag    730

 cactgtcttt tattatagga ttagtaagat atacaagaaa ataaccaccg tgttgtgaaa    790

 aagtgaccaa aatcatgtac taaatgcaca gctttatgta ccctgtccac catcttgtgc    850

 ctcttctcca tttgcctctt ccttcctatt tcccttccgc taaggaaaaa aattggtgtc    910

 acatttgtaa aagtaatttt aatagttaat catctctgag agtaacctgt attttaattg    970

 ttgaaactta accaaaataa gatactgtct cagctagggc ttgtcatttg tgtatttagt   1030

 gttaagatag gaatgctagt gtctctttaa ttaattggaa atagatggag gctaaaaatg   1090

 aaggtttttc tttgaaactg aattaacttg ggaatatttg ttgttaaaaa cttctttttg   1150

 cccaaaataa ctcattttgt attatctgaa aatatataat ttctggtcat gtgtatgtta   1210

 aaatagaaaa ttttgaggaa aaatggaaat agggtggaaa agtactcggt aaacagtagt   1270

 aaccaaatat tttcactcca gatttgtgtt ttctctggca cagagtagat cttttgggaa   1330

 atatatatga aagtggatta agtttgacta cccttatgtt agccacatct ggatgagaac   1390

 agttacaaag agtttggtct ctaagttgat ttgtacccag tgggtcaact tctgcaaaat   1450

 tccgtaatgg tgtattagta ttagaatagt gaataaaatg ggaaagttat acatgtatac   1510

 ttattatctt gctcagtatt ttatctcact tgttctagaa ttttctgtaa accctgctac   1570

 tgggtttgaa gagttttagt catcctttaa caatttttaa aaatttagct tctagattcc   1630

 atttggtaag gaaatcaata ttggaagtat tgctaaaatc ttataatatg aaaagagatc   1690

 cactaatgta gcttaaggtt attagatttg ggcttttaat catggaataa tcttatgtat   1750

 tggtgtaaga gttgatgaat gactttagct gtgtgaatat ataatagtca aactgcaaac   1810

 attttgcatc ccttttgtga cctaatttac agacatttaa attgtgttgc agttctgctt   1870

 tgccgtttaa taaaaagcta tttcagaaaa aaaaaaaaa                          1909




      <210> 44
      <211> 827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(747)

      <400> 44
 aaactacatt ttgcaaagtc attgaactct gagctcagtt gcagtactcg ggaagcc        57                                                                 
 atg cag gat gaa gat gga tac atc acc tta aat att aaa act cgg aaa      105
 Met Gln Asp Glu Asp Gly Tyr Ile Thr Leu Asn Ile Lys Thr Arg Lys
   1               5                  10                  15

 cca gct ctc gtc tcc gtt ggc tct gca tcc tcc tcc tgg tgg cgt gtg      153
 Pro Ala Leu Val Ser Val Gly Ser Ala Ser Ser Ser Trp Trp Arg Val
              20                  25                  30

 atg gct ttg att ctg ctg atc ctg tgc gtg ggg atg gtt gtc ggg ctg      201
 Met Ala Leu Ile Leu Leu Ile Leu Cys Val Gly Met Val Val Gly Leu
          35                  40                  45

 gtg gct ctg ggg att tgg tct gtc atg cag cgc aat tac cta caa gat      249
 Val Ala Leu Gly Ile Trp Ser Val Met Gln Arg Asn Tyr Leu Gln Asp
      50                  55                  60

 gag aat gaa aat cgc aca gga act ctg caa caa tta gca aag cgc ttc      297
 Glu Asn Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe
  65                  70                  75                  80

 tgt caa tat gtg gta aaa caa tca gaa cta aag ggc act ttc aaa ggt      345
 Cys Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly
                  85                  90                  95

 cat aaa tgc agc ccc tgt gac aca aac tgg aga tat tat gga gat agc      393
 His Lys Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser
             100                 105                 110

 tgc tat ggg ttc ttc agg cac aac tta aca tgg gaa gag agt aag cag      441
 Cys Tyr Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln
         115                 120                 125

 tac tgc act gac atg aat gct act ctc ctg aag att gac aac cgg aac      489
 Tyr Cys Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn
     130                 135                 140

 att gtg gag tac atc aaa gcc agg act cat tta att cgt tgg gtc gga      537
 Ile Val Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly
 145                 150                 155                 160

 tta tct cgc cag aag tcg aat gag gtc tgg aag tgg gag gat ggc tcg      585
 Leu Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser
                 165                 170                 175

 gtt atc tca gaa aat atg ttt gag ttt ttg gaa gat gga aaa gga aat      633
 Val Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn
             180                 185                 190

 atg aat tgt gct tat ttt cat aat ggg aaa atg cac cct acc ttc tgt      681
 Met Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys
         195                 200                 205

 gag aac aaa cat tat tta atg tgt gag agg aag gct ggc atg acc aag      729
 Glu Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys
     210                 215                 220

 gtg gac caa cta cct taa tgcaaa gaggtggaca ggataacaca gataagggct      783
 Val Asp Gln Leu Pro 
 225

 ttattgtaca ataaaagata tgtatgaatg caaaaaaaaa aaaa                     827




      <210> 45
      <211> 705
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (92)..(658)

      <400> 45
 tcactgcgcc ggggtagtgg gccccagtgt tgcgctctct ggccgttcct tacactctgc     60

 ttcaggctcc agtgcagggg cgtagtggga t   atg gcc aac tcg ggc tgc aag     112
                                      Met Ala Asn Ser Gly Cys Lys
                                        1               5

 gac gtc acg ggt cca gat gag gag agt ttt ctg tac ttt gcc tac ggc      160
 Asp Val Thr Gly Pro Asp Glu Glu Ser Phe Leu Tyr Phe Ala Tyr Gly
          10                  15                  20

 agc aac ctg ctg aca gag agg atc cac ctc cga aac ccc tcg gcg gcg      208
 Ser Asn Leu Leu Thr Glu Arg Ile His Leu Arg Asn Pro Ser Ala Ala
      25                  30                  35

 ttc ttc tgt gtg gcc cgc ctg cag gat ttt aag ctt gac ttt ggc aat      256
 Phe Phe Cys Val Ala Arg Leu Gln Asp Phe Lys Leu Asp Phe Gly Asn
  40                  45                  50                  55

 tcc caa ggc aaa aca agt caa act tgg cat gga ggg ata gcc acc att      304
 Ser Gln Gly Lys Thr Ser Gln Thr Trp His Gly Gly Ile Ala Thr Ile
                  60                  65                  70

 ttt cag agt cct ggc gat gaa gtg tgg gga gta gta tgg aaa atg aac      352
 Phe Gln Ser Pro Gly Asp Glu Val Trp Gly Val Val Trp Lys Met Asn
              75                  80                  85

 aaa agc aat tta aat tct ctg gat gag caa gaa ggg gtt aaa agt gga      400
 Lys Ser Asn Leu Asn Ser Leu Asp Glu Gln Glu Gly Val Lys Ser Gly
          90                  95                 100

 atg tat gtt gta ata gaa gtt aaa gtt gca act caa gaa gga aaa gaa      448
 Met Tyr Val Val Ile Glu Val Lys Val Ala Thr Gln Glu Gly Lys Glu
     105                 110                 115

 ata acc tgt cga agt tat ctg atg aca aat tac gaa agt gct ccc cca      496
 Ile Thr Cys Arg Ser Tyr Leu Met Thr Asn Tyr Glu Ser Ala Pro Pro
 120                 125                 130                 135

 tcc cca cag tat aaa aag att att tgc atg ggt gca aaa gaa aat ggt      544
 Ser Pro Gln Tyr Lys Lys Ile Ile Cys Met Gly Ala Lys Glu Asn Gly
                 140                 145                 150

 ttg ccg ctg gag tat caa gag aag tta aaa gca ata gaa cca aat gac      592
 Leu Pro Leu Glu Tyr Gln Glu Lys Leu Lys Ala Ile Glu Pro Asn Asp
             155                 160                 165

 tat aca gga aag gtc tca gaa gaa att gaa gac atc atc aaa aag ggg      640
 Tyr Thr Gly Lys Val Ser Glu Glu Ile Glu Asp Ile Ile Lys Lys Gly
         170                 175                 180

 gaa aca caa act ctt tag aacata acagaatata tctaagggta ttctatgtgc      694
 Glu Thr Gln Thr Leu 
     185

 taatataaaa t                                                         705




      <210> 46
      <211> 1554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(1507)

      <400> 46
 ctctgcggac cggtccggaa ttcccgggtc gacgatttcg tcagcaatcg cagcc atg      58
                                                              Met
                                                                1

 gcg tcg tta ctg tgg gga ggc gac gca ggg gcg gcg gag agc gag cgg      106
 Ala Ser Leu Leu Trp Gly Gly Asp Ala Gly Ala Ala Glu Ser Glu Arg
               5                  10                  15

 ctg aac agc cac ttt tca aac ctc agc caa ccc cgg aag aac ctt tgg      154
 Leu Asn Ser His Phe Ser Asn Leu Ser Gln Pro Arg Lys Asn Leu Trp
          20                  25                  30

 ggt att aag agt act gca gtc cga aac ata gat ggt tct att aat aac      202
 Gly Ile Lys Ser Thr Ala Val Arg Asn Ile Asp Gly Ser Ile Asn Asn
      35                  40                  45

 atc aat gaa gat gat gaa gaa gat gta gtg gat ttg gca gct aat tca      250
 Ile Asn Glu Asp Asp Glu Glu Asp Val Val Asp Leu Ala Ala Asn Ser
  50                  55                  60                  65

 ctc tta aac aag tta atc cat caa tcc tta gta gaa tcc agt cac cgt      298
 Leu Leu Asn Lys Leu Ile His Gln Ser Leu Val Glu Ser Ser His Arg
                  70                  75                  80

 gtg gaa gtt tta cag aag gat ccc agc tct cca ctt tac tca gta aag      346
 Val Glu Val Leu Gln Lys Asp Pro Ser Ser Pro Leu Tyr Ser Val Lys
              85                  90                  95

 aca ttt gaa gag ctg cgg cta aag gaa gag tta cta aaa gga atc tat      394
 Thr Phe Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile Tyr
         100                 105                 110

 gca atg gga ttt aat agg cca tct aaa atc caa gag atg gct ctc cct      442
 Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro
     115                 120                 125

 atg atg ctg gca cat cca ccc cag aac ctc ata gca cag agc cag tct      490
 Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser
 130                 135                 140                 145

 gga aca gga aag aca gcg gca ttt gtg ttg gca atg tta agc aga gtt      538
 Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val
                 150                 155                 160

 aat gcc ttg gaa ttg ttc cca cag tgc ctc tgc cta gct cct act tat      586
 Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr
             165                 170                 175

 gaa ttg gct ctg caa act ggc cgt gtg gtt gag cag atg gga aaa ttc      634
 Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys Phe
         180                 185                 190

 tgt gtg gat gtt caa gtg atg tat gcc att cga ggg aat cga att ccc      682
 Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro
     195                 200                 205

 aga ggc acc gac atc act aaa cag att ata att ggc act cct ggg act      730
 Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr
 210                 215                 220                 225

 gtc cta gat tgg tgt ttt aaa cta aaa ttg att gat ttg act aag att      778
 Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys Ile
                 230                 235                 240

 cgt gtg ttt gtc ctg gat gaa gca gat gtg atg att gac act caa gga      826
 Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly
             245                 250                 255

 ttc tca gat cat agt atc cgt att caa aga gct cta ccc tcc gaa tgc      874
 Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu Cys
         260                 265                 270

 caa atg ctc ctc ttt tca gca acc ttt gag gac tct gtg tgg cac ttt      922
 Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His Phe
     275                 280                 285

 gct gag cga atc atc cct gac cct aat gtt atc aag tta cgc aaa gag      970
 Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys Glu
 290                 295                 300                 305

 gag ctc aca ctg aac aac atc cgg caa tat tac gtg ctg tgt gag cac     1018
 Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu His
                 310                 315                 320

 agg aaa gac aaa tac caa gct ctg tgc aac att tat ggc agc atc acc     1066
 Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile Thr
             325                 330                 335

 att ggt cag gcc atc atc ttc tgc cag act cgt cga aac gct aag tgg     1114
 Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys Trp
         340                 345                 350

 ttg acc gtg gag atg ata cag gat ggc cac cag gtg tct ttg tta agc     1162
 Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu Ser
     355                 360                 365

 ggg gag ctg acc gtg gag cag cga gct tcc atc att cag agg ttt cgg     1210
 Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe Arg
 370                 375                 380                 385

 gat ggg aaa gag aag gtt ctc ata aca act aat gtt tgc gcc cga ggg     1258
 Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg Gly
                 390                 395                 400

 att gat gtg aag cag gtc aca att gtt gtg aac ttt gat ctc cct gta     1306
 Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro Val
             405                 410                 415

 aaa caa gga gag gag ccg gac tat gag acc tac ctc cac cgc ata ggg     1354
 Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile Gly
         420                 425                 430

 cgg acg ggg cgc ttt ggg aaa aaa ggc ctt gcc ttc aac atg att gaa     1402
 Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile Glu
     435                 440                 445

 gta gat gag ctg ccc tcg ctc atg aaa atc cag gac cac ttt aac agc     1450
 Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn Ser
 450                 455                 460                 465

 agt att aag caa ctc aac gct gaa gac atg gat gaa att gaa aag att     1498
 Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys Ile
                 470                 475                 480

 gac tat tga agaaaga actttattgt ttgtgcagta tcctagttta tgtgagaatg     1554
 Asp Tyr 






      <210> 47
      <211> 4769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (604)..(2109)

      <400> 47
 cccgggtcga cttcgctgtc gacgatttcg tcagctccgc ttcctcacac tttgcatgct     60

 gcctggcttc agctacttcc ccacggaaaa gccgagagag cgctcagaac aacgacagcg    120

 gaagaacagc ttatctgatg actggctggg tgggaagcac aactgggagg acttgaagga    180

 ctttggaaga ctaagttagc tacaaagaaa actaagtatt ataccaaaaa aacttatccg    240

 ggcgtggtga caggcgcctg tagtcccagc cccagtagtt gcagacagga gaaagcacct    300

 tctccaacag gtcctgctct aatctcaggt gcctcacctg ttcattgtgc agctgatggc    360

 acagttgagc tcaaagcagg tcctagtaag aatataccta acccttcagc ctcatcaaag    420

 acagatgcta gtgtgccagt ggctgtaact ccctcccctt taacatcttt attgaccaca    480

 gccactttag aaaagcttcc tgtaccccag gtcagtgcaa ctacagcacc tgctggatca    540

 gctccaccct cgagcacttt gccagcagct tctagcctta aaaccccagg aacttcttta    600

 aac  atg aat gga ccc act tta aga cca acc tct agt atc cct gct aat     648
      Met Asn Gly Pro Thr Leu Arg Pro Thr Ser Ser Ile Pro Ala Asn
        1               5                  10                  15

 aat cct tta gtg act cag ctg ctt caa ggc aaa gat gtt ccc atg gag      696
 Asn Pro Leu Val Thr Gln Leu Leu Gln Gly Lys Asp Val Pro Met Glu
                  20                  25                  30

 caa att ctg cct aaa cct ctc acc aaa gtt gaa atg aaa acg gtt cca      744
 Gln Ile Leu Pro Lys Pro Leu Thr Lys Val Glu Met Lys Thr Val Pro
              35                  40                  45

 ctg act gca aaa gag gaa agg ggg atg gga gcg ctc ata gct acc aac      792
 Leu Thr Ala Lys Glu Glu Arg Gly Met Gly Ala Leu Ile Ala Thr Asn
          50                  55                  60

 aca aca gaa aat agc acc aga gag gaa gtt aat gag aga cag tcc cat      840
 Thr Thr Glu Asn Ser Thr Arg Glu Glu Val Asn Glu Arg Gln Ser His
      65                  70                  75

 cca gct acg cag cag cag ctg ggc aaa acc ttg caa agt aag cag ctc      888
 Pro Ala Thr Gln Gln Gln Leu Gly Lys Thr Leu Gln Ser Lys Gln Leu
  80                  85                  90                  95

 ccc cag gtt cca agg ccc ctt cag ctc ttt tca gct aag gag ctg agg      936
 Pro Gln Val Pro Arg Pro Leu Gln Leu Phe Ser Ala Lys Glu Leu Arg
                 100                 105                 110

 gac tcc agc att gac aca cac caa tac cac gaa gga cta agt aaa gca      984
 Asp Ser Ser Ile Asp Thr His Gln Tyr His Glu Gly Leu Ser Lys Ala
             115                 120                 125

 acc caa gat cag atc ctt cag act ctc att cag agg gtt cgg agg cag     1032
 Thr Gln Asp Gln Ile Leu Gln Thr Leu Ile Gln Arg Val Arg Arg Gln
         130                 135                 140

 aat ctt ctc tca gtt gtg ccg ccc tca cag ttc aac ttc gct cac tca     1080
 Asn Leu Leu Ser Val Val Pro Pro Ser Gln Phe Asn Phe Ala His Ser
     145                 150                 155

 ggt ttc cag ctg gaa gac atc tcc aca agc cag agg ttc atg ctg ggt     1128
 Gly Phe Gln Leu Glu Asp Ile Ser Thr Ser Gln Arg Phe Met Leu Gly
 160                 165                 170                 175

 ttt gct ggc aga agg aca tcc aaa cct gca atg gca ggg cac tac tta     1176
 Phe Ala Gly Arg Arg Thr Ser Lys Pro Ala Met Ala Gly His Tyr Leu
                 180                 185                 190

 ctg aat att tct acc tac ggc cgg ggc tca gag agc ttt agg agg acc     1224
 Leu Asn Ile Ser Thr Tyr Gly Arg Gly Ser Glu Ser Phe Arg Arg Thr
             195                 200                 205

 cat tct gta aac cct gaa gat cgt ttt tgt cta agc agc ccc act gaa     1272
 His Ser Val Asn Pro Glu Asp Arg Phe Cys Leu Ser Ser Pro Thr Glu
         210                 215                 220

 gcc ttg aaa atg gga tat aca gac tgt aaa aat gca aca gga gag agt     1320
 Ala Leu Lys Met Gly Tyr Thr Asp Cys Lys Asn Ala Thr Gly Glu Ser
     225                 230                 235

 agc agc agc aaa gaa gat gac act gat gag gaa agt act ggt gat gag     1368
 Ser Ser Ser Lys Glu Asp Asp Thr Asp Glu Glu Ser Thr Gly Asp Glu
 240                 245                 250                 255

 cag gaa tct gtc aca gtg aaa gag gag ccc cag gtt tcc cag agt gct     1416
 Gln Glu Ser Val Thr Val Lys Glu Glu Pro Gln Val Ser Gln Ser Ala
                 260                 265                 270

 ggc aag ggt gac aca agt tca gga cct cac agc agg gaa act cta tct     1464
 Gly Lys Gly Asp Thr Ser Ser Gly Pro His Ser Arg Glu Thr Leu Ser
             275                 280                 285

 acc agt gat tgc tta gct agc aag aat gtg aag gct gag ata cca ttg     1512
 Thr Ser Asp Cys Leu Ala Ser Lys Asn Val Lys Ala Glu Ile Pro Leu
         290                 295                 300

 aat gag caa acc act tta agt aag gag aat tac ctg ttc act aga ggc     1560
 Asn Glu Gln Thr Thr Leu Ser Lys Glu Asn Tyr Leu Phe Thr Arg Gly
     305                 310                 315

 caa aca ttt gat gaa aag acc cta gcc aga gat tta att cag gca gca     1608
 Gln Thr Phe Asp Glu Lys Thr Leu Ala Arg Asp Leu Ile Gln Ala Ala
 320                 325                 330                 335

 cag aag cag atg gct cat gca gtg aga ggt aag gca atc cgt agc agc     1656
 Gln Lys Gln Met Ala His Ala Val Arg Gly Lys Ala Ile Arg Ser Ser
                 340                 345                 350

 ccc gag ctt ttc agt tct act gtt ctt cct ctg cct gca gac agc ccc     1704
 Pro Glu Leu Phe Ser Ser Thr Val Leu Pro Leu Pro Ala Asp Ser Pro
             355                 360                 365

 acc cac cag ccc cta ctc ctt cca ccc ctg caa acc ccg aag ttg tat     1752
 Thr His Gln Pro Leu Leu Leu Pro Pro Leu Gln Thr Pro Lys Leu Tyr
         370                 375                 380

 gga agc ccc acc cag ata ggg cca agc tat aga ggc atg atc aat gtc     1800
 Gly Ser Pro Thr Gln Ile Gly Pro Ser Tyr Arg Gly Met Ile Asn Val
     385                 390                 395

 tcc acc tca tct gac atg gac cat aac tct gct gta cca ggt agc cag     1848
 Ser Thr Ser Ser Asp Met Asp His Asn Ser Ala Val Pro Gly Ser Gln
 400                 405                 410                 415

 gta tct agc aat gta ggt gat gtc atg tca ttt tca gtg act gtc act     1896
 Val Ser Ser Asn Val Gly Asp Val Met Ser Phe Ser Val Thr Val Thr
                 420                 425                 430

 acc atc cct gct agc caa gct atg aat ccc agc agc cat ggc cag acc     1944
 Thr Ile Pro Ala Ser Gln Ala Met Asn Pro Ser Ser His Gly Gln Thr
             435                 440                 445

 att cct gtt cag gcg ttc tcc gaa gag aac agc ata gag ggc acg cct     1992
 Ile Pro Val Gln Ala Phe Ser Glu Glu Asn Ser Ile Glu Gly Thr Pro
         450                 455                 460

 tcg aaa tgt tac tgc cgc ttg aaa gcc atg atc atg tgc aaa ggc tgt     2040
 Ser Lys Cys Tyr Cys Arg Leu Lys Ala Met Ile Met Cys Lys Gly Cys
     465                 470                 475

 ggc gct ttc tgc cat gat gat tgc atc ggc ccc tcc aaa ctg tgc gtc     2088
 Gly Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys Leu Cys Val
 480                 485                 490                 495

 tcc tgc ctt gtc gtt cgg taa tg agactagaaa gagatacact gtaaaggagg     2141
 Ser Cys Leu Val Val Arg 
                 500

 gggaagggaa gggttgacca gttgggtttt ttgcgtcctt ttggaatcac agaaataaac   2201

 aagtaggttt cagttgtctt cagagacaaa tgttacttaa tcaggaatac aaagtacaga   2261

 ttttttacat tttagaggaa gagcaccttg tatagtaagt ctaagtcaag caagactttg   2321

 tgaatttgtg acaagtttgc acttacaaaa tcatgtaaat atgtcacatt ttgtttaaca   2381

 ttatttttcc aagtgtttag gtaataatgt attactttga attcagatta atgttctact   2441

 acttgtgact gagaaaagtt taatgccggc atggtaaaag gaagctgtct cccttctgac   2501

 atttcctagg aagctaggaa aaggaaagtg aaggaatggt ctaaagaaat gaccattcac   2561

 actgattttg tctggacagt ctggccgcag gttattcata gattattcag tctttgcagg   2621

 acttggattc agggttttac tcagtccctt taccttaggt ggaatcttct taaattgaaa   2681

 tttttggtaa ggaattcatt tcacaggtag tgtttcagac tctgaaagcc ctgacttggt   2741

 tcttggcttc tactgtacta gttactagtt actggtactg ttgccaagca atctgcttgg   2801

 aatttgtgga tccctgctgt tccctaatcc caccccctgc cctgagacag tgaatgtagt   2861

 ccgtgaaggg agtgcctctc tgggaccccc tgtgttgtta caggctgtgc agtgcaacaa   2921

 ttccagcaaa aataccctat ccccgcactt agtcattcgt ggtaactaac aattttgaaa   2981

 tactcatata aaatgaacag gaaagtgtta gtgattgggt gatttgagct acatcttgtt   3041

 gagcaagggg agtgaaacca cagaaactgt taaattgaac gtaaataact ttggaaaaca   3101

 gttttgacac tagaacaagg tcgcttctct tttcctcttc tctcccaacc tgttaaccta   3161

 gtgctagata gtcagctgct gttgcaggta gaaaagctca ccaatgccac atttgttcat   3221

 tctgttcaac ctgttttgac ctcccaggca tctgaacagg atgacatcat cttattatat   3281

 cttactttac acatacgtgt atgtacacac acacacacaa tacaagacat ttttcctgtt   3341

 ttagaaaata tagcccttgt ttggattact gctgtctgag cactagaaat ttctaatgga   3401

 aagaggcctc tgaatggcta agggaacatc tggaaaggaa ggaaaatgag ccctaaaggt   3461

 tttttggttg cttgtttttg tttctttttc tttcttgttt ccttttttgt ttttaaatcc   3521

 ttctctagtg actgaagaaa ttgtgagtac ataatattta ggtcatggtt aaggaacatt   3581

 aaaataaacc tgcagtttaa cagaattttg tattaaatgg gggagtgtca atttgcatca   3641

 tttgcatatt gatttcaagt ctcctaattt ggaatgggta aagtacaaat gttaatgcaa   3701

 catagtacag ttgtatttgt ccttcatatt caggatgtga tatttacaaa atgcagaaca   3761

 gtttaaactt gttaagtcac attccagatt aggagaaaat gggcaataat catctctgtt   3821

 ttgcccccat tctactaccc accactgccc accccacccc cacatcacac actcttcgat   3881

 gctttcccac agcccctgct ccgctcctct ccgtaagaaa ctcacttcac tgtttttcac   3941

 ttttcacttc tggctttttt gtggcccaag gccaatatag gattaatatc tgtgttccag   4001

 cttcagccag aacgatatgt ctgtccatct ttctcctttc ttccagcaca cacagctaag   4061

 agataagaag gctgcaagga ttggggataa ggagtatatt ttcaagccaa gaaccagtag   4121

 aaaacagaaa taatggtgct cccaaatatt cagtaccttg ggcaatccag gaagggttta   4181

 aagagacctg ttgctgcata gaactctccc tgccctaccc cttaactcca ccttagtgcc   4241

 agggccgagg gctggtctgc atgctggaag aggttgagag ttttggaatt gattccatgc   4301

 taaatgtcag ttaccagttt ggattgatga aagtgatttt tctgctttac ctttttcctg   4361

 tcagaaaggt tttcctctgt gctaccctta acttagggat gaacagacta taactaggaa   4421

 aggaggaaag gtatcaggga tttttaagtc cgtttagaga gcaaaccata ttgtgcctct   4481

 tcatcttgac ccaggctctt atagataggt cctaaacatt gctgttcact agattatctt   4541

 aacaaataat actcagctaa atatttgcat ttaggaatac tcctaaaaca gatattgcca   4601

 actagataca ctgcctcaat cttgaccaga caagagaaca gttaagttct ctcagttggg   4661

 tagtaacttg aataccagtc tatttatcag ttggtttcaa cacagaggtt tcaagtggaa   4721

 agccattcat cttaaaagct gaacagaaaa attaaaaaaa aaaaaaaa                4769




      <210> 48
      <211> 1163
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(917)

      <400> 48
 cccgggtcga cccacgcgtc cggcgccggc cccgttgccc ccgcgcgcgc gcacactcgc     60

 gagccccggc gacatgcaaa tgagctggct ccagtgccca gacccaagcc ccccactgct    120

 ca   atg gac acc ccc agc cca gac ccg ttg cct tcg cct ttg ccc ggg     167
      Met Asp Thr Pro Ser Pro Asp Pro Leu Pro Ser Pro Leu Pro Gly
        1               5                  10                  15

 gag gaa gag aaa cct ctg gcc tta tct cct cct gtt ccc cgg ggc cgc      215
 Glu Glu Glu Lys Pro Leu Ala Leu Ser Pro Pro Val Pro Arg Gly Arg
                  20                  25                  30

 cga ggc cgt cgt cct ggg gga gcc acc tcc tca aat cgg aca ctc aag      263
 Arg Gly Arg Arg Pro Gly Gly Ala Thr Ser Ser Asn Arg Thr Leu Lys
              35                  40                  45

 gcc tcc ctc cct cgc aag cgg ggc cgc ccc ccc aag tca ggg cag gag      311
 Ala Ser Leu Pro Arg Lys Arg Gly Arg Pro Pro Lys Ser Gly Gln Glu
          50                  55                  60

 ccc cca ctg gtg cag gtg cag ggg gtg aca gcc cca gta ggc agc agt      359
 Pro Pro Leu Val Gln Val Gln Gly Val Thr Ala Pro Val Gly Ser Ser
      65                  70                  75

 ggc ggg agc gac ctc ctc ctg atc gat gat cag ggt gtg ccc tat acg      407
 Gly Gly Ser Asp Leu Leu Leu Ile Asp Asp Gln Gly Val Pro Tyr Thr
  80                  85                  90                  95

 gtc tct gaa ggt tca gcg gct ggg cct gag ggc tct ggc ccc agg aag      455
 Val Ser Glu Gly Ser Ala Ala Gly Pro Glu Gly Ser Gly Pro Arg Lys
                 100                 105                 110

 gcc cca cac ttc tgc ccg gtg tgc ctg cgg gcc ttc ccc tac ctc tcc      503
 Ala Pro His Phe Cys Pro Val Cys Leu Arg Ala Phe Pro Tyr Leu Ser
             115                 120                 125

 gac ctg gag cgc cac agc atc tcg cac tca gag ctg aag ccg cac cag      551
 Asp Leu Glu Arg His Ser Ile Ser His Ser Glu Leu Lys Pro His Gln
         130                 135                 140

 tgc aag gtt tgc ggc aag acc ttc aag cgc tcc agc cac ctg cgg cgg      599
 Cys Lys Val Cys Gly Lys Thr Phe Lys Arg Ser Ser His Leu Arg Arg
     145                 150                 155

 cac tgc aac atc cat gcc ggc ctg cgg ccc ttc cgc tgc ccg ctg tgc      647
 His Cys Asn Ile His Ala Gly Leu Arg Pro Phe Arg Cys Pro Leu Cys
 160                 165                 170                 175

 ccc cgc cgc ttc cgc gag gcg ggc gag ctg gcg cac cac cat cgc gtg      695
 Pro Arg Arg Phe Arg Glu Ala Gly Glu Leu Ala His His His Arg Val
                 180                 185                 190

 cac tcg ggg gag cgc ccg tac cag tgc ccc atc tgc cgg ctg cgc ttt      743
 His Ser Gly Glu Arg Pro Tyr Gln Cys Pro Ile Cys Arg Leu Arg Phe
             195                 200                 205

 aca gag gcc aac acg ctc cgg cgc cat gcg aag cgc aag cac ccg gag      791
 Thr Glu Ala Asn Thr Leu Arg Arg His Ala Lys Arg Lys His Pro Glu
         210                 215                 220

 gcc atg ggg gta ccc ctg tgt gca cca gat cca ggg tct gaa ccg ccg      839
 Ala Met Gly Val Pro Leu Cys Ala Pro Asp Pro Gly Ser Glu Pro Pro
     225                 230                 235

 tgg gac gag gag ggc atc ccg gcc aca gca ggg gcc gag gaa gag gag      887
 Trp Asp Glu Glu Gly Ile Pro Ala Thr Ala Gly Ala Glu Glu Glu Glu
 240                 245                 250                 255

 gag aca gag ggg aaa ggg gag ccg gcc tga c ccacaccccc ggccatcgct      938
 Glu Thr Glu Gly Lys Gly Glu Pro Ala 
                 260

 ccctgggcca ggtttagagc agggagtttg gctggtgctg ggcctgagcc agggggccgg    998

 gacacccttg tttccggtgg tcttcccgtt gtgggagcag gtggagggtg gagacctaaa   1058

 ctttggggtc cagctgcctt cagcccccct cccccagact aacagaccct tggaggcagg   1118

 ggctgtggaa ataaatctct gcctgctggc aaaaaaaaaa aaaaa                   1163




      <210> 49
      <211> 1603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1560)

      <400> 49
 gactatacag gacatgttca tcctggaact tacacaaata ccttagaacg tctagtgaag     60

 gaa  atg gaa gac aca caa agg cta gat gaa ctg cag aag caa cta caa     108
      Met Glu Asp Thr Gln Arg Leu Asp Glu Leu Gln Lys Gln Leu Gln
        1               5                  10                  15

 gaa gac ata agg caa ggc cga ggc att aaa tcc cca atc aga att gga      156
 Glu Asp Ile Arg Gln Gly Arg Gly Ile Lys Ser Pro Ile Arg Ile Gly
                  20                  25                  30

 gaa gaa gac agt aca gat gat gag gat ggc ctc tta gaa gag cac aag      204
 Glu Glu Asp Ser Thr Asp Asp Glu Asp Gly Leu Leu Glu Glu His Lys
              35                  40                  45

 gaa ttt cta aag aaa ttt tca gtt aca att gat gct att cct gat cat      252
 Glu Phe Leu Lys Lys Phe Ser Val Thr Ile Asp Ala Ile Pro Asp His
          50                  55                  60

 cat cca ggt gaa gaa ata ttt aat ttc ctc aat tct gga aaa att ttc      300
 His Pro Gly Glu Glu Ile Phe Asn Phe Leu Asn Ser Gly Lys Ile Phe
      65                  70                  75

 aat cag tat acc ttg gat tta aga gac tct ggt ttt att gga caa agt      348
 Asn Gln Tyr Thr Leu Asp Leu Arg Asp Ser Gly Phe Ile Gly Gln Ser
  80                  85                  90                  95

 gct gta gaa aaa ctt att ctt aaa tcg gga aaa aca gat cag att ttt      396
 Ala Val Glu Lys Leu Ile Leu Lys Ser Gly Lys Thr Asp Gln Ile Phe
                 100                 105                 110

 ttg aca aca caa ggt ttc ctt acg tct gct tat cac tat gtc cag tgt      444
 Leu Thr Thr Gln Gly Phe Leu Thr Ser Ala Tyr His Tyr Val Gln Cys
             115                 120                 125

 cct gtc cct gtg tta aag tgg ctg ttt cgg atg atg tca gtt cat aca      492
 Pro Val Pro Val Leu Lys Trp Leu Phe Arg Met Met Ser Val His Thr
         130                 135                 140

 gac tgt att gtg tca gtg cag att tta agt aca ttg atg gaa ata aca      540
 Asp Cys Ile Val Ser Val Gln Ile Leu Ser Thr Leu Met Glu Ile Thr
     145                 150                 155

 att aga aat gat acc ttc agt gac tca cca gtt tgg cca tgg atc cca      588
 Ile Arg Asn Asp Thr Phe Ser Asp Ser Pro Val Trp Pro Trp Ile Pro
 160                 165                 170                 175

 tca ttg tct gat gta gca gct gtg ttt ttc aat atg ggg att gat ttt      636
 Ser Leu Ser Asp Val Ala Ala Val Phe Phe Asn Met Gly Ile Asp Phe
                 180                 185                 190

 aga tct ttg ttt ccc ctg gag aat ctt cag cca gac ttt aat gaa gac      684
 Arg Ser Leu Phe Pro Leu Glu Asn Leu Gln Pro Asp Phe Asn Glu Asp
             195                 200                 205

 tat cta gtt tct gaa aca cag aca aca tca agg ggg aaa gaa agt gaa      732
 Tyr Leu Val Ser Glu Thr Gln Thr Thr Ser Arg Gly Lys Glu Ser Glu
         210                 215                 220

 gat tca tct tat aag cca att ttt tca aca ctt cct gaa acc aac att      780
 Asp Ser Ser Tyr Lys Pro Ile Phe Ser Thr Leu Pro Glu Thr Asn Ile
     225                 230                 235

 tta aat gtg gtt aag ttt cta ggc ttg tgt aca tct ata cat cca gaa      828
 Leu Asn Val Val Lys Phe Leu Gly Leu Cys Thr Ser Ile His Pro Glu
 240                 245                 250                 255

 ggt tac cag gat cgt gaa ata atg ttg ctg att tta atg tta ttt aaa      876
 Gly Tyr Gln Asp Arg Glu Ile Met Leu Leu Ile Leu Met Leu Phe Lys
                 260                 265                 270

 atg agt ttg gaa aaa cag ctg aaa cag att cct tta gta gac ttt caa      924
 Met Ser Leu Glu Lys Gln Leu Lys Gln Ile Pro Leu Val Asp Phe Gln
             275                 280                 285

 agc ctc ctg ata aac ctg atg aaa aac atc aga gat tgg aac aca aag      972
 Ser Leu Leu Ile Asn Leu Met Lys Asn Ile Arg Asp Trp Asn Thr Lys
         290                 295                 300

 gtg cct gaa ctc tgt ctg ggc ata aat gaa ctc tcc agt cat ccc cac     1020
 Val Pro Glu Leu Cys Leu Gly Ile Asn Glu Leu Ser Ser His Pro His
     305                 310                 315

 aac ctc ctg tgg ttg gta cag ctg gtc cct aat tgg aca tca cgt gga     1068
 Asn Leu Leu Trp Leu Val Gln Leu Val Pro Asn Trp Thr Ser Arg Gly
 320                 325                 330                 335

 agg caa ctg aga cag tgc ctc agt cta gtg att att tca aag ctt ttg     1116
 Arg Gln Leu Arg Gln Cys Leu Ser Leu Val Ile Ile Ser Lys Leu Leu
                 340                 345                 350

 gat gag aaa cac gaa gat gtt cct aat gcc agt aat ctg cag gta tca     1164
 Asp Glu Lys His Glu Asp Val Pro Asn Ala Ser Asn Leu Gln Val Ser
             355                 360                 365

 gtc cta cat cgc tat ctt gtg cag atg aag cct tct gat ttg tta aag     1212
 Val Leu His Arg Tyr Leu Val Gln Met Lys Pro Ser Asp Leu Leu Lys
         370                 375                 380

 aaa atg gtc ttg aag aaa aag gct gaa caa cca gat ggc att att gat     1260
 Lys Met Val Leu Lys Lys Lys Ala Glu Gln Pro Asp Gly Ile Ile Asp
     385                 390                 395

 gac agt ctt cat tta gaa ctt gaa aag cag gca tat tac ctg acc tac     1308
 Asp Ser Leu His Leu Glu Leu Glu Lys Gln Ala Tyr Tyr Leu Thr Tyr
 400                 405                 410                 415

 att ctt ctt cat tta gtc ggt gaa gtt agt tgt tct cat tct ttt tct     1356
 Ile Leu Leu His Leu Val Gly Glu Val Ser Cys Ser His Ser Phe Ser
                 420                 425                 430

 tct gga caa cgg aaa cac ttt gtg cta ctc tgt ggg gct ttg gaa aag     1404
 Ser Gly Gln Arg Lys His Phe Val Leu Leu Cys Gly Ala Leu Glu Lys
             435                 440                 445

 cat gtt aaa tgt gat att agg gaa gat gca aga ctt ttt tac aga act     1452
 His Val Lys Cys Asp Ile Arg Glu Asp Ala Arg Leu Phe Tyr Arg Thr
         450                 455                 460

 aag gtg aaa gac ttg gtc gcc agg ata cat gga aaa tgg cag gaa ata     1500
 Lys Val Lys Asp Leu Val Ala Arg Ile His Gly Lys Trp Gln Glu Ile
     465                 470                 475

 atc cag aac tgt cgg cct act cag ggg cag ctt cat gac ttc tgg gta     1548
 Ile Gln Asn Cys Arg Pro Thr Gln Gly Gln Leu His Asp Phe Trp Val
 480                 485                 490                 495

 cca gat tct taa tag gagttgcagc agcaaaaata tgaaccaaga gaaattcaat     1603
 Pro Asp Ser 






      <210> 50
      <211> 2592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1428)

      <400> 50
 gactatacag gacatgttca tcctggaact tacacaaata ccttagaacg tctagtgaag     60

 gaa  atg gaa gac aca caa agg cta gat gaa ctg cag aag caa cta caa     108
      Met Glu Asp Thr Gln Arg Leu Asp Glu Leu Gln Lys Gln Leu Gln
        1               5                  10                  15

 gaa gac ata agg caa ggc cga ggc att aaa tcc cca atc aga att gga      156
 Glu Asp Ile Arg Gln Gly Arg Gly Ile Lys Ser Pro Ile Arg Ile Gly
                  20                  25                  30

 gaa gaa gac agt aca gat gat gag gat ggc ctc tta gaa gag cac aag      204
 Glu Glu Asp Ser Thr Asp Asp Glu Asp Gly Leu Leu Glu Glu His Lys
              35                  40                  45

 gaa ttt cta aag aaa ttt tca gtt aca att gat gct att cct gat cat      252
 Glu Phe Leu Lys Lys Phe Ser Val Thr Ile Asp Ala Ile Pro Asp His
          50                  55                  60

 cat cca ggt gaa gaa ata ttt aat ttc ctc aat tct gga aaa att ttc      300
 His Pro Gly Glu Glu Ile Phe Asn Phe Leu Asn Ser Gly Lys Ile Phe
      65                  70                  75

 aat cag tat acc ttg gat tta aga gac tct ggt ttt att gga caa agt      348
 Asn Gln Tyr Thr Leu Asp Leu Arg Asp Ser Gly Phe Ile Gly Gln Ser
  80                  85                  90                  95

 gct gta gaa aaa ctt att ctt aaa tcg gga aaa aca gat cag att ttt      396
 Ala Val Glu Lys Leu Ile Leu Lys Ser Gly Lys Thr Asp Gln Ile Phe
                 100                 105                 110

 ttg aca aca caa ggt ttc ctt acg tct gct tat cac tat gtc cag tgt      444
 Leu Thr Thr Gln Gly Phe Leu Thr Ser Ala Tyr His Tyr Val Gln Cys
             115                 120                 125

 cct gtc cct gtg tta aag tgg ctg ttt cgg atg atg tca gtt cat aca      492
 Pro Val Pro Val Leu Lys Trp Leu Phe Arg Met Met Ser Val His Thr
         130                 135                 140

 gac tgt att gtg tca gtg cag att tta agt aca ttg atg gaa ata aca      540
 Asp Cys Ile Val Ser Val Gln Ile Leu Ser Thr Leu Met Glu Ile Thr
     145                 150                 155

 att aga aat gat acc ttc agt gac tca cca gtt tgg cca tgg atc cca      588
 Ile Arg Asn Asp Thr Phe Ser Asp Ser Pro Val Trp Pro Trp Ile Pro
 160                 165                 170                 175

 tca ttg tct gat gta gca gct gtg ttt ttc aat atg ggg att gat ttt      636
 Ser Leu Ser Asp Val Ala Ala Val Phe Phe Asn Met Gly Ile Asp Phe
                 180                 185                 190

 aga tct ttg ttt ccc ctg gag aat ctt cag cca gac ttt aat gaa gac      684
 Arg Ser Leu Phe Pro Leu Glu Asn Leu Gln Pro Asp Phe Asn Glu Asp
             195                 200                 205

 tat cta gtt tct gaa aca cag aca aca tca agg ggg aaa gaa agt gaa      732
 Tyr Leu Val Ser Glu Thr Gln Thr Thr Ser Arg Gly Lys Glu Ser Glu
         210                 215                 220

 gat tca tct tat aag cca att ttt tca aca ctt cct gaa acc aac att      780
 Asp Ser Ser Tyr Lys Pro Ile Phe Ser Thr Leu Pro Glu Thr Asn Ile
     225                 230                 235

 tta aat gtg gtt aag ttt cta ggc ttg tgt aca tct ata cat cca gaa      828
 Leu Asn Val Val Lys Phe Leu Gly Leu Cys Thr Ser Ile His Pro Glu
 240                 245                 250                 255

 ggt tac cag gat cgt gaa ata atg ttg ctg att tta atg tta ttt aaa      876
 Gly Tyr Gln Asp Arg Glu Ile Met Leu Leu Ile Leu Met Leu Phe Lys
                 260                 265                 270

 atg agt ttg gaa aaa cag ctg aaa cag att cct tta gta gac ttt caa      924
 Met Ser Leu Glu Lys Gln Leu Lys Gln Ile Pro Leu Val Asp Phe Gln
             275                 280                 285

 agc ctc ctg ata aac ctg atg aaa aac atc aga gat tgg aac aca aag      972
 Ser Leu Leu Ile Asn Leu Met Lys Asn Ile Arg Asp Trp Asn Thr Lys
         290                 295                 300

 gtg cct gaa ctc tgt ctg ggc ata aat gaa ctc tcc agt cat ccc cac     1020
 Val Pro Glu Leu Cys Leu Gly Ile Asn Glu Leu Ser Ser His Pro His
     305                 310                 315

 aac ctc ctg tgg ttg gta cag ctg gtc cct aat tgg aca tca cgt gga     1068
 Asn Leu Leu Trp Leu Val Gln Leu Val Pro Asn Trp Thr Ser Arg Gly
 320                 325                 330                 335

 agg caa ctg aga cag tgc ctc agt cta gtg att att tca aag ctt ttg     1116
 Arg Gln Leu Arg Gln Cys Leu Ser Leu Val Ile Ile Ser Lys Leu Leu
                 340                 345                 350

 gat gag aaa cac gaa gat gtt cct aat gcc agt aat ctg cag gca tat     1164
 Asp Glu Lys His Glu Asp Val Pro Asn Ala Ser Asn Leu Gln Ala Tyr
             355                 360                 365

 tac ctg acc tac att ctt ctt cat tta gtc ggt gaa gtt agt tgt tct     1212
 Tyr Leu Thr Tyr Ile Leu Leu His Leu Val Gly Glu Val Ser Cys Ser
         370                 375                 380

 cat tct ttt tct tct gga caa cgg aaa cac ttt gtg cta ctc tgt ggg     1260
 His Ser Phe Ser Ser Gly Gln Arg Lys His Phe Val Leu Leu Cys Gly
     385                 390                 395

 gct ttg gaa aag cat gtt aaa tgt gat att agg gaa gat gca aga ctt     1308
 Ala Leu Glu Lys His Val Lys Cys Asp Ile Arg Glu Asp Ala Arg Leu
 400                 405                 410                 415

 ttt tac aga act aag gtg aaa gac ttg gtc gcc agg ata cat gga aaa     1356
 Phe Tyr Arg Thr Lys Val Lys Asp Leu Val Ala Arg Ile His Gly Lys
                 420                 425                 430

 tgg cag gaa ata atc cag aac tgt cgg cct act cag ggg cag ctt cat     1404
 Trp Gln Glu Ile Ile Gln Asn Cys Arg Pro Thr Gln Gly Gln Leu His
             435                 440                 445

 gac ttc tgg gta cca gat tct taa taggagttgc agcagcaaaa atatgaacca    1458
 Asp Phe Trp Val Pro Asp Ser 
         450

 agagaaattc aataagagcc tttcatagag gagtagaaag gattattaca gaatccaatg   1518

 aatgccaaga aaatgtacag caaatgtgcc acttgaatat ctagtatgaa gctggtaatg   1578

 aagaaattgc catttctgaa gcagatatga aatatgatct gcttaattgt taaggcaact   1638

 gacctttcaa aagtgcagag tcttattaaa agaggggagg ggtagaagca gaataatagt   1698

 catatgtcta acctgcccca gttaactcct cttgttaaat tataagccag ttatcttttt   1758

 tagatagtat ttttgtcact tggataatca caggaaatat ataagaaaag agcttggact   1818

 aacttgagaa gttggacatg gaaagcaaga ccaagttcca gttgggttta attttccctc   1878

 ttggttattt tcggacacaa agggaatgct taaaactgag tttagtaata aaaagcataa   1938

 atctcttctg taacttttat aaaccacagg gaggtttcaa tccatgcatt ttccttcatt   1998

 actcaagatt ataaatctgt ttttaaaata catctaaaca aacagttgag aaacaaaagt   2058

 ttggcatgtt gtcagatccc cttaagagga agaggttaag ctgtaaagta gtggccctgt   2118

 tttgatgcca gaacattcat atgctgtttg ttctggattt cttttaaatg catgtatttt   2178

 aaatactggt taaatcttag aatcttggct atatcttaga attctggctc ttggtaacca   2238

 tattacagaa gtctatattg taaaagccta aagatctgga caagtttcca acaaccttgt   2298

 ttccatgagt atataatttt ggcagacacc tgaattcttt gggacactgt gtctgtgtat   2358

 gtgtgtgtgt gtgtgtgtgt gtgtgtgcgc ttgtatcttg aagttgttgc acttcaaaac   2418

 cacagctgct gtaaattctt aaacactgga gagccatcct ttggtttaaa tggtagaggg   2478

 ttagtggaag tgcacacgtt gttttttagc ccaggggtgg gaacaaactc ttatttaccc   2538

 aacttgaaaa ttatttttgt ggacgaaaag tcccctttta ggaaggtttg tttc         2592




      <210> 51
      <211> 1745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (185)..(883)

      <400> 51
 tttcgtgtgc gagcgtggac ctgggacggg tctgggcggc tctcggtggt tggcacgggt     60

 tcgcacaccc attcaagcgg caggacgcac ttgtcttagc agttctcgct gaccgcgcta    120

 gctgcggctt ctacgctccg gcactctgag ttcatcagca aacgccctgg cgtctgtcct    180

 cacc atg cct agc ctt tgg gac cgc ttc tcg tcg tcg tcc acc tcc tct     229
      Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser
        1               5                  10                  15

 tcg ccc tcg tcc ttg ccc cga act ccc acc cca gat cgg ccg ccg cgc      277
 Ser Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg
                  20                  25                  30

 tca gcc tgg ggg tcg gcg acc cgg gag gag ggg ttt gac cgc tcc acg      325
 Ser Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr
              35                  40                  45

 agc ctg gag agc tcg gac tgc gag tcc ctg gac agc agc aac agt ggc      373
 Ser Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly
          50                  55                  60

 ttc ggg ccg gag gaa gac acg gct tac ctg gat ggg gtg tcg ttg ccc      421
 Phe Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro
      65                  70                  75

 gac ttc gag ctg ctc agt gac cct gag gat gaa cac ttg tgt gcc aac      469
 Asp Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn
  80                  85                  90                  95

 ctg atg cag ctg ctg cag gag agc ctg gcc cag gcg cgg ctg ggc tct      517
 Leu Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser
                 100                 105                 110

 cga cgc cct gcg cgc ctg ctg atg cct agc cag ttg gta agc cag gtg      565
 Arg Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val
             115                 120                 125

 ggc aaa gaa cta ctg cgc ctg gcc tac agc gag ccg tgc ggc ctg cgg      613
 Gly Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg
         130                 135                 140

 ggg gcg ctg ctg gac gtc tgc gtg gag cag ggc aag agc tgc cac agc      661
 Gly Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser
     145                 150                 155

 gtg ggc cag ctg gca ctc gac ccc agc ctg gtg ccc acc ttc cag ctg      709
 Val Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu
 160                 165                 170                 175

 acc ctc gtg ctg cgc ctg gac tca cga ctc tgg ccc aag atc cag ggg      757
 Thr Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly
                 180                 185                 190

 ctg ttt agc tcc gcc aac tct ccc ttc ctc cct ggc ttc agc cag tcc      805
 Leu Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser
             195                 200                 205

 ctg acg ctg agc act ggc ttc cga gtc atc aag aag aag ctg tac agc      853
 Leu Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser
         210                 215                 220

 tcg gaa cag ctg ctc att gag gag tgt tga a cttcaacctg agggggccga      904
 Ser Glu Gln Leu Leu Ile Glu Glu Cys 
     225                 230

 cagtgccctc caagacagag acgactgaac ttttggggtg gagactagag gcaggagctg    964

 agggactgat tccagtggtt ggaaaactga ggcagccacc taaggtggag gtgggggaat   1024

 agtgtttccc aggaagctca ttgagttgtg tgcgggtggc tgtgcattgg ggacacatac   1084

 ccctcagtac tgtagcatga aacaaaggct taggggccaa caaggcttcc agctggatgt   1144

 gtgtgtagca tgtaccttat tatttttgtt actgacagtt aacagtggtg tgacatccag   1204

 agagcagctg ggctgctccc gccccagcct ggcccagggt gaaggaagag gcacgtgctc   1264

 ctcagagcag ccggagggag gggggaggtc ggaggtcgtg gaggtggttt gtgtatctta   1324

 ctggtctgaa gggaccaagt gtgtttgttg tttgttttgt atcttgtttt tctgatcgga   1384

 gcatcactac tgacctgttg taggcagcta tcttacagac gcatgaatgt aagagtagga   1444

 aggggtgggt gtcagggatc acttgggatc tttgacactt gaaaaattac acctggcagc   1504

 tgcgtttaag ccttccccca tcgtgtactg cagagttgag ctggcagggg aggggctgag   1564

 agggtggggg ctggaacccc tccccgggag gagtgccatc tgggtcttcc atctagaact   1624

 gtttacatga agataagata ctcactgttc atgaatacac ttgatgttca agtattaaga   1684

 cctatgcaat attttttact tttctaataa acatgtttgt taaaacaaaa aaaaaaaaaa   1744

 a                                                                   1745




      <210> 52
      <211> 1200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(1106)

      <400> 52
 gcacgaggcg taggacggag ggtagtgcgt ctagagacac atattcccaa cggatttgac     60

 gatggtgttc ggtcttgaat ggaaatgtag tcttaggcca gtcttaggtt tttgaacagg    120

 atagtaggta tccggagtcg attgagggcc agagcaggca ctggggttcg gatcctgggc    180

 aaagtttccc acgttgaggg tctcgaggac gcctagatct ctttcccagg gcc   atg     236
                                                              Met
                                                                1

 gcg aac ccg aag ctg ctg gga ctg gag cta agc gag gcg gag gcg atc      284
 Ala Asn Pro Lys Leu Leu Gly Leu Glu Leu Ser Glu Ala Glu Ala Ile
               5                  10                  15

 ggt gct gat tcg gcg cga ttt gag gag ctg ctg ctg cag gcc tcg aag      332
 Gly Ala Asp Ser Ala Arg Phe Glu Glu Leu Leu Leu Gln Ala Ser Lys
          20                  25                  30

 gag ctc cag caa gcc cag aca acc aga cca gaa tcg aca caa atc cag      380
 Glu Leu Gln Gln Ala Gln Thr Thr Arg Pro Glu Ser Thr Gln Ile Gln
      35                  40                  45

 cct cag cct ggt ttc tgc ata aag acc aac tcc tcg gaa ggg aag gtt      428
 Pro Gln Pro Gly Phe Cys Ile Lys Thr Asn Ser Ser Glu Gly Lys Val
  50                  55                  60                  65

 ttc atc aac atc tgc cac tcc ccc tct atc cct cct ccc gcc gac gtg      476
 Phe Ile Asn Ile Cys His Ser Pro Ser Ile Pro Pro Pro Ala Asp Val
                  70                  75                  80

 acc gag gag gag ctg ctt cag atg cta gag gag gac caa gct ggg ttt      524
 Thr Glu Glu Glu Leu Leu Gln Met Leu Glu Glu Asp Gln Ala Gly Phe
              85                  90                  95

 cgc atc ccc atg agt ctg gga gag cct cat gca gaa ctg gat gca aaa      572
 Arg Ile Pro Met Ser Leu Gly Glu Pro His Ala Glu Leu Asp Ala Lys
         100                 105                 110

 ggc cag gga tgt acc gcc tac gac gta gct gtc aac agc gac ttc tac      620
 Gly Gln Gly Cys Thr Ala Tyr Asp Val Ala Val Asn Ser Asp Phe Tyr
     115                 120                 125

 cgg agg atg cag aac agc gat ttc ttg cgg gag ctc gtg atc acc atc      668
 Arg Arg Met Gln Asn Ser Asp Phe Leu Arg Glu Leu Val Ile Thr Ile
 130                 135                 140                 145

 gcc agg gag ggc ctt gag gac aaa tac aac ttg cag ctg aat ccg gaa      716
 Ala Arg Glu Gly Leu Glu Asp Lys Tyr Asn Leu Gln Leu Asn Pro Glu
                 150                 155                 160

 tgg cgc atg atg aag aac cgg cca ttc atg ggc tcc atc tcg cag cag      764
 Trp Arg Met Met Lys Asn Arg Pro Phe Met Gly Ser Ile Ser Gln Gln
             165                 170                 175

 aac atc cgc tcg gag cag cgt cct cgg atc cag gag ctg ggg gac ctg      812
 Asn Ile Arg Ser Glu Gln Arg Pro Arg Ile Gln Glu Leu Gly Asp Leu
         180                 185                 190

 tac acg ccc gcc ccc ggg aga gct gag tca ggg cct gaa aag cct cac      860
 Tyr Thr Pro Ala Pro Gly Arg Ala Glu Ser Gly Pro Glu Lys Pro His
     195                 200                 205

 ctg aac ctg tgg ctg gaa gcc ccc gac ctc ctc ttg gcc gaa gtt gac      908
 Leu Asn Leu Trp Leu Glu Ala Pro Asp Leu Leu Leu Ala Glu Val Asp
 210                 215                 220                 225

 ctc ccc aaa ctg gat gga gcc ctg ggg ctg tcg ctg gag atc ggg gag      956
 Leu Pro Lys Leu Asp Gly Ala Leu Gly Leu Ser Leu Glu Ile Gly Glu
                 230                 235                 240

 aac cgc ctg gtg atg ggg ggc ccc cag cag ctg tat cat cta gac gct     1004
 Asn Arg Leu Val Met Gly Gly Pro Gln Gln Leu Tyr His Leu Asp Ala
             245                 250                 255

 tat atc ccg ctg cag atc aac tct cat gag agc aag gca gcc ttc cac     1052
 Tyr Ile Pro Leu Gln Ile Asn Ser His Glu Ser Lys Ala Ala Phe His
         260                 265                 270

 cgg aag aga aag caa tta atg gtg gcc atg ccg ctt ctg ccg gtg cct     1100
 Arg Lys Arg Lys Gln Leu Met Val Ala Met Pro Leu Leu Pro Val Pro
     275                 280                 285

 tct tga tcagggtgtc tccttgtgct tctgagatgt ggagaagagg ctgctggctt      1156
 Ser 
 290

 ccctaaaagt tgaaataaaa gatttttgcc tttaaaaaaa aaaa                    1200




      <210> 53
      <211> 2550
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (267)..(1646)

      <400> 53
 gcaatcgccg cagccgcccc cgccgtcggc cgccgcaccc caagcgactg cccaaactaa     60

 gcctccgtgg ctgggtacgg gagcgctttg gggacaaaaa ttctccctca actgtggtct    120

 gcattccttc ggcccgtggg ctgatctggg gcgggaagta ttagcgtctc agttgcgctg    180

 cagccgggga ggaaggagga ggccgagcct ggggcggagt ttgggctgac tggggctgga    240

 ccgggcaaga cgccgccgct gcccgg atg ttg cga tgg ctg atc ggg gga ggc     293
                              Met Leu Arg Trp Leu Ile Gly Gly Gly
                                1               5

 cga gaa ccg cag gga ctg gcc gag aaa tct cct tta cag aca ata ggt      341
 Arg Glu Pro Gln Gly Leu Ala Glu Lys Ser Pro Leu Gln Thr Ile Gly
  10                  15                  20                  25

 gaa gaa caa acc cag aat ccc tac act gaa ctg cta gta ctg aag gct      389
 Glu Glu Gln Thr Gln Asn Pro Tyr Thr Glu Leu Leu Val Leu Lys Ala
                  30                  35                  40

 cat cat gat att gta cga ttt ctg gta cag tta gat gac tac aga ttt      437
 His His Asp Ile Val Arg Phe Leu Val Gln Leu Asp Asp Tyr Arg Phe
              45                  50                  55

 gca tct gct ggt gat gat gga att gta gtt gtg tgg aat gcc cag aca      485
 Ala Ser Ala Gly Asp Asp Gly Ile Val Val Val Trp Asn Ala Gln Thr
          60                  65                  70

 ggg gaa aaa ctt tta gaa ctg aat gga cac act caa aag ata aca gct      533
 Gly Glu Lys Leu Leu Glu Leu Asn Gly His Thr Gln Lys Ile Thr Ala
      75                  80                  85

 att att aca ttt cct tcc ttg gaa tct tgt gaa gag aaa aat caa ctc      581
 Ile Ile Thr Phe Pro Ser Leu Glu Ser Cys Glu Glu Lys Asn Gln Leu
  90                  95                 100                 105

 atc ttg aca gcc tct gct gat aga aca gtt att gtg tgg gat ggt gat      629
 Ile Leu Thr Ala Ser Ala Asp Arg Thr Val Ile Val Trp Asp Gly Asp
                 110                 115                 120

 act acc aga caa gtt cag aga ata tca tgc ttc cag tct act gta aag      677
 Thr Thr Arg Gln Val Gln Arg Ile Ser Cys Phe Gln Ser Thr Val Lys
             125                 130                 135

 tgt tta act gtt ctt cag aga cta gat gtt tgg ctt tct ggt ggg aat      725
 Cys Leu Thr Val Leu Gln Arg Leu Asp Val Trp Leu Ser Gly Gly Asn
         140                 145                 150

 gac ctg tgt gtg tgg aac cga aaa tta gat ctc ctg tgt aag act agc      773
 Asp Leu Cys Val Trp Asn Arg Lys Leu Asp Leu Leu Cys Lys Thr Ser
     155                 160                 165

 cac ctt tct gat aca ggt att agt gct ttg gtt gaa ata cct aag aac      821
 His Leu Ser Asp Thr Gly Ile Ser Ala Leu Val Glu Ile Pro Lys Asn
 170                 175                 180                 185

 tgt gtt gtg gca gca gtt ggc aaa gaa ctg ata att ttc agg ttg gta      869
 Cys Val Val Ala Ala Val Gly Lys Glu Leu Ile Ile Phe Arg Leu Val
                 190                 195                 200

 gca ccc aca gaa gga tca cta gaa tgg gat att ctt gaa gtt aag cgc      917
 Ala Pro Thr Glu Gly Ser Leu Glu Trp Asp Ile Leu Glu Val Lys Arg
             205                 210                 215

 ctc ctt gat cac cag gat aat att ctc tca ttg att aat gtc aat gat      965
 Leu Leu Asp His Gln Asp Asn Ile Leu Ser Leu Ile Asn Val Asn Asp
         220                 225                 230

 ttg agt ttt gtc acc ggc tcc cac gtc gga gag ctg atc atc tgg gat     1013
 Leu Ser Phe Val Thr Gly Ser His Val Gly Glu Leu Ile Ile Trp Asp
     235                 240                 245

 gcc ctg gac tgg acc atg cag gcc tat gaa cgc aac ttc tgg gac cca     1061
 Ala Leu Asp Trp Thr Met Gln Ala Tyr Glu Arg Asn Phe Trp Asp Pro
 250                 255                 260                 265

 tct cca caa ctg gac acc caa caa gaa ata aaa ctc tgt caa aaa tca     1109
 Ser Pro Gln Leu Asp Thr Gln Gln Glu Ile Lys Leu Cys Gln Lys Ser
                 270                 275                 280

 aat gac att tct att cat cat ttc aca tgt gat gaa gag aat gta ttt     1157
 Asn Asp Ile Ser Ile His His Phe Thr Cys Asp Glu Glu Asn Val Phe
             285                 290                 295

 gct gca gtt gga agg ggt tta tac gtg tat agc ctt caa atg aag cgt     1205
 Ala Ala Val Gly Arg Gly Leu Tyr Val Tyr Ser Leu Gln Met Lys Arg
         300                 305                 310

 gtg att gcc tgc cag aaa act gca cat gac tcc aat gtc ctg cac att     1253
 Val Ile Ala Cys Gln Lys Thr Ala His Asp Ser Asn Val Leu His Ile
     315                 320                 325

 gcc aga ctt cca aac agg cag tta atc tca tgc tca gaa gat ggc agt     1301
 Ala Arg Leu Pro Asn Arg Gln Leu Ile Ser Cys Ser Glu Asp Gly Ser
 330                 335                 340                 345

 gta cgc att tgg gag tta aga gaa aaa cag cag ctt gca gct gag cct     1349
 Val Arg Ile Trp Glu Leu Arg Glu Lys Gln Gln Leu Ala Ala Glu Pro
                 350                 355                 360

 gta cca aca ggt ttt ttt aac atg tgg gga ttt gga aga gtc agc aaa     1397
 Val Pro Thr Gly Phe Phe Asn Met Trp Gly Phe Gly Arg Val Ser Lys
             365                 370                 375

 caa gcc agc caa cct gtt aaa aag cag caa gaa aat gct act tca tgt     1445
 Gln Ala Ser Gln Pro Val Lys Lys Gln Gln Glu Asn Ala Thr Ser Cys
         380                 385                 390

 tca ctg gag ctt att gga gat ttg att gga cac tca tca tct gtg gag     1493
 Ser Leu Glu Leu Ile Gly Asp Leu Ile Gly His Ser Ser Ser Val Glu
     395                 400                 405

 atg ttt cta tac ttt gaa gat cat gga cta gtg acg tgc tcc gct gat     1541
 Met Phe Leu Tyr Phe Glu Asp His Gly Leu Val Thr Cys Ser Ala Asp
 410                 415                 420                 425

 cat ctc att att ttg tgg aaa aat gga gag cga gaa tct gga ttg cgc     1589
 His Leu Ile Ile Leu Trp Lys Asn Gly Glu Arg Glu Ser Gly Leu Arg
                 430                 435                 440

 agt tta aga tta ttt caa aaa tta gag gag aat ggt gac tta tac ctt     1637
 Ser Leu Arg Leu Phe Gln Lys Leu Glu Glu Asn Gly Asp Leu Tyr Leu
             445                 450                 455

 gct gtc tag tttaagg aattaaaaat acacatgcat gaaccttgaa catcaaatat     1693
 Ala Val 


 cgggtactac tctgaaaacc attaatatat tgatcactta aattggtaat tttttttgtc   1753

 agtccataaa attctacatg tttaaatttt ttgtggacct accaaccagg aacatgttgc   1813

 ttctcaggtc ctagtatatc ctccaaagaa tataccacaa gtttttccat ttgactttga   1873

 gctgctgttg aagtggtgag tgctgtgttt tgagcttatt ttgaacctag atccttgtga   1933

 aaggtacaaa tagaggtaat agttaagtta tggcatttat tagaagtttt attatttggc   1993

 ttcctttaga attattgtga agtttaaaaa tagcctttct cctgcaaatt ttcctagtct   2053

 ttagtaactg ttagtgttct atatagcaca aacttgaatc tctcagccaa aaaagggaac   2113

 atatatactg tttaagtatg gcaagttttc tttggtacca atttgtttag ataattttaa   2173

 aaatgttttt tagttctagc tactaaaacc tgtatgaact caaatggata ggcatcttgt   2233

 gagggtgtgt ttttcccagt gtgaattggc ttgaagagcc atgggctaaa tgggtactag   2293

 aacaacaact gcccctcatg tacgccaagg atgagctcta gatcatttga gaggcacagt   2353

 gtttccggag tcagggactg cagctgagcg caactgcccc atctgaccac tgactcaaat   2413

 acgaactgct tgagacagac ttcttttatg tagttctttg cagtgtccat tgagacacta   2473

 taaccagcct tgtaacaata tgttttctcc ttttggtgct aaaaaataaa aatattagaa   2533

 agtaaaaaaa aaaaaaa                                                  2550




      <210> 54
      <211> 1665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (250)..(1209)

      <400> 54
 gcacgaggat agtcggcagt tctggcccct gcagctggag gtaccctgag ttctgagggt     60

 cgtagtgctg tttctggtat tctcatcgcg gtcacctcta ccggtgtgga caagtaaagt    120

 ttgaatcagc ttctccatgg cctgggcacc agttcccggc tgagccattt tccttttggc    180

 taaaagtccc cgcccagagg ccaattcgtc gcggcggcgg tggagatcgc aggtcgctca    240

 ggcttgcag    atg ggt caa ggg ttg tgg aga gtg gtc aga aac cag cag     288
              Met Gly Gln Gly Leu Trp Arg Val Val Arg Asn Gln Gln
                1               5                  10

 ctg caa caa gaa ggc tac agt gag caa ggc tac ctc acc aga gag cag      336
 Leu Gln Gln Glu Gly Tyr Ser Glu Gln Gly Tyr Leu Thr Arg Glu Gln
      15                  20                  25

 agc agg aga atg gct gcg agc aac att tct aac acc aat cat cgt aaa      384
 Ser Arg Arg Met Ala Ala Ser Asn Ile Ser Asn Thr Asn His Arg Lys
  30                  35                  40                  45

 caa gtc caa gga ggc att gac ata tat cat ctt ttg aag gca agg aaa      432
 Gln Val Gln Gly Gly Ile Asp Ile Tyr His Leu Leu Lys Ala Arg Lys
                  50                  55                  60

 tcg aaa gaa cag gaa gga ttc att aat ttg gaa atg ttg cct cct gag      480
 Ser Lys Glu Gln Glu Gly Phe Ile Asn Leu Glu Met Leu Pro Pro Glu
              65                  70                  75

 cta agc ttt acc atc ttg tcc tac ctg aat gca act gac ctt tgc ttg      528
 Leu Ser Phe Thr Ile Leu Ser Tyr Leu Asn Ala Thr Asp Leu Cys Leu
          80                  85                  90

 gct tca tgt gtt tgg cag gac ctt gcg aat gat gaa ctt ctc tgg caa      576
 Ala Ser Cys Val Trp Gln Asp Leu Ala Asn Asp Glu Leu Leu Trp Gln
      95                 100                 105

 ggg ttg tgc aaa tcc act tgg ggt cac tgt tcc ata tac aat aag aac      624
 Gly Leu Cys Lys Ser Thr Trp Gly His Cys Ser Ile Tyr Asn Lys Asn
 110                 115                 120                 125

 cca cct tta gga ttt tct ttt aga aaa ttg tat atg cag ctg gat gaa      672
 Pro Pro Leu Gly Phe Ser Phe Arg Lys Leu Tyr Met Gln Leu Asp Glu
                 130                 135                 140

 ggc agc ctc acc ttt aat gcc aac cca gat gag gga gtg aac tac ttt      720
 Gly Ser Leu Thr Phe Asn Ala Asn Pro Asp Glu Gly Val Asn Tyr Phe
             145                 150                 155

 atg tcc aag ggt atc ctg gat gat tcg cca aag gaa ata gca aag ttt      768
 Met Ser Lys Gly Ile Leu Asp Asp Ser Pro Lys Glu Ile Ala Lys Phe
         160                 165                 170

 atc ttc tgt aca aga aca cta aat tgg aaa aaa ctg aga atc tat ctt      816
 Ile Phe Cys Thr Arg Thr Leu Asn Trp Lys Lys Leu Arg Ile Tyr Leu
     175                 180                 185

 gat gaa agg aga gat gtc ttg gat gac ctt gta aca ttg cat aat ttt      864
 Asp Glu Arg Arg Asp Val Leu Asp Asp Leu Val Thr Leu His Asn Phe
 190                 195                 200                 205

 aga aat cag ttc ttg cca aat gca ctg aga gaa ttt ttt cgt cat atc      912
 Arg Asn Gln Phe Leu Pro Asn Ala Leu Arg Glu Phe Phe Arg His Ile
                 210                 215                 220

 cat gcc cct gaa gag cgt gga gag tat ctt gaa act ctt ata aca aag      960
 His Ala Pro Glu Glu Arg Gly Glu Tyr Leu Glu Thr Leu Ile Thr Lys
             225                 230                 235

 ttc tca cat aga ttc tgt gct tgc aac cct gat tta atg cga gaa ctt     1008
 Phe Ser His Arg Phe Cys Ala Cys Asn Pro Asp Leu Met Arg Glu Leu
         240                 245                 250

 ggc ctt agt cct gat gct gtc tat gta ctg tgc tac tct ttg att cta     1056
 Gly Leu Ser Pro Asp Ala Val Tyr Val Leu Cys Tyr Ser Leu Ile Leu
     255                 260                 265

 ctt tcc att gac ctc act agc cct cat gtg aag aat aaa atg tca aaa     1104
 Leu Ser Ile Asp Leu Thr Ser Pro His Val Lys Asn Lys Met Ser Lys
 270                 275                 280                 285

 agg gaa ttt att cga aat acc cgt cgc gct gct caa aat att agt gaa     1152
 Arg Glu Phe Ile Arg Asn Thr Arg Arg Ala Ala Gln Asn Ile Ser Glu
                 290                 295                 300

 gat ttt gta ggg cat ctt tat gac aat atc tac ctt att ggc cat gtg     1200
 Asp Phe Val Gly His Leu Tyr Asp Asn Ile Tyr Leu Ile Gly His Val
             305                 310                 315

 gct gca taa aaagcac aattgctagg acttcagttt ttacttcaga ctaaagctac     1256
 Ala Ala 


 ccaaggactt agcagatatg ggggttacat cagtgctggt cattgtagcc tgagtataca   1316

 atcaagcttc agtgtgcaac ctttttttct tttgccattt tctattttag taatttcctt   1376

 ggggaactaa ataattttgc agaatttttc ctaattttgt ttatcacgtt ttgcacaaag   1436

 cagagccact gtctaacaca gctgttaacg aatgataaac tgacattata ctctaaaaga   1496

 tggtgtattt gtgcattaga tttgcctgaa aaactttatc catttccatt ctttatacaa   1556

 ataccatgta atgtgtacat atttaactaa agagatttat agtcataatt attttattgt   1616

 aaagatttta actaaagttt ttccttttct ctcaaaaaaa aaaaaaaaa               1665




      <210> 55
      <211> 2138
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (290)..(1354)

      <400> 55
 gcacgagtcg ggctcgagac agcggcgacg tttaaagctg agcgacccag tgccactgga     60

 gacggtcagc ttctccactc aggctcctcc agcccgagcc agaagacccc ctcccccaga    120

 attctggggg ccgatggaag ggagccgagt cagatcgcga ggtacccaga gccgacagac    180

 cggagcgaca gggagttgcc agaagccccg cccctaggag tgatcggaaa gcctcaccca    240

 tccgggtgag gaacccggag ggaccgcctc cgggcggagc ccgccgacc    atg gct     295
                                                          Met Ala
                                                            1

 acg ccc ctg gtg gcg ggt ccc gca gct cta cgc ttc gcc gcc gcg gct      343
 Thr Pro Leu Val Ala Gly Pro Ala Ala Leu Arg Phe Ala Ala Ala Ala
           5                  10                  15

 agc tgg cag gtt gtg cgc gga cgc tgc gtg gaa cat ttt ccg cga gta      391
 Ser Trp Gln Val Val Arg Gly Arg Cys Val Glu His Phe Pro Arg Val
      20                  25                  30

 ctg gag ttt ctg cga tct ctg cgc gct gtt gcc cct ggc ttg gtt cgc      439
 Leu Glu Phe Leu Arg Ser Leu Arg Ala Val Ala Pro Gly Leu Val Arg
  35                  40                  45                  50

 tac cgg cac cac gaa cgc ctt tgt atg ggc cta aag gcc aag gtg gtg      487
 Tyr Arg His His Glu Arg Leu Cys Met Gly Leu Lys Ala Lys Val Val
                  55                  60                  65

 gtg gag ctg atc ctg cag ggc cgg cct tgg gcc caa gtc ctg aaa gcc      535
 Val Glu Leu Ile Leu Gln Gly Arg Pro Trp Ala Gln Val Leu Lys Ala
              70                  75                  80

 ctg aat cac cac ttt cca gaa tct gga cct ata gtg cgg gat ccc aag      583
 Leu Asn His His Phe Pro Glu Ser Gly Pro Ile Val Arg Asp Pro Lys
          85                  90                  95

 gct aca aag cag gat ctg agg aag att ttg gag gca cag gaa act ttt      631
 Ala Thr Lys Gln Asp Leu Arg Lys Ile Leu Glu Ala Gln Glu Thr Phe
     100                 105                 110

 tac cag cag gtg aag cag ctg tca gag gct cct gtg gat ttg gcc tcg      679
 Tyr Gln Gln Val Lys Gln Leu Ser Glu Ala Pro Val Asp Leu Ala Ser
 115                 120                 125                 130

 aag ctg cag gaa ctt gaa caa gag tat ggg gaa ccc ttt ctg gct gcc      727
 Lys Leu Gln Glu Leu Glu Gln Glu Tyr Gly Glu Pro Phe Leu Ala Ala
                 135                 140                 145

 atg gaa aag ctg ctt ttt gag tac ttg tgt cag ctg gag aaa gca ctg      775
 Met Glu Lys Leu Leu Phe Glu Tyr Leu Cys Gln Leu Glu Lys Ala Leu
             150                 155                 160

 cct aca ccg cag gca cag cag ctt cag gat gtg ctg agt tgg atg cag      823
 Pro Thr Pro Gln Ala Gln Gln Leu Gln Asp Val Leu Ser Trp Met Gln
         165                 170                 175

 cct gga gtc tct atc acc tct tct ctt gcc tgg aga caa tat ggt gtg      871
 Pro Gly Val Ser Ile Thr Ser Ser Leu Ala Trp Arg Gln Tyr Gly Val
     180                 185                 190

 gac atg ggg tgg ctg ctt cca gag tgc tct gtt act gac tca gtg aac      919
 Asp Met Gly Trp Leu Leu Pro Glu Cys Ser Val Thr Asp Ser Val Asn
 195                 200                 205                 210

 ctg gct gag ccc atg gaa cag aat cct cct cag caa caa aga cta gca      967
 Leu Ala Glu Pro Met Glu Gln Asn Pro Pro Gln Gln Gln Arg Leu Ala
                 215                 220                 225

 ctc cac aat ccc ctg cca aaa gcc aag cct ggc aca cat ctt cct cag     1015
 Leu His Asn Pro Leu Pro Lys Ala Lys Pro Gly Thr His Leu Pro Gln
             230                 235                 240

 gga cca tct tca agg acg cac cca gaa cct cta gct ggc cga cac ttc     1063
 Gly Pro Ser Ser Arg Thr His Pro Glu Pro Leu Ala Gly Arg His Phe
         245                 250                 255

 aat ctg gcc cct cta ggc cga cga aga gtt cag tcc caa tgg gcc tcc     1111
 Asn Leu Ala Pro Leu Gly Arg Arg Arg Val Gln Ser Gln Trp Ala Ser
     260                 265                 270

 act agg gga ggc cat aag gag cgc ccc aca gtc atg ctg ttt ccc ttt     1159
 Thr Arg Gly Gly His Lys Glu Arg Pro Thr Val Met Leu Phe Pro Phe
 275                 280                 285                 290

 agg aat ctc ggc tca cca acc cag gtc ata tct aag cct gag agc aag     1207
 Arg Asn Leu Gly Ser Pro Thr Gln Val Ile Ser Lys Pro Glu Ser Lys
                 295                 300                 305

 gaa gaa cat gcg ata tac aca gca gac cta gcc atg ggc aca aga gca     1255
 Glu Glu His Ala Ile Tyr Thr Ala Asp Leu Ala Met Gly Thr Arg Ala
             310                 315                 320

 gcc tcc act ggg aag tct aag agt cca tgc cag acc ctg ggg gga agg     1303
 Ala Ser Thr Gly Lys Ser Lys Ser Pro Cys Gln Thr Leu Gly Gly Arg
         325                 330                 335

 gct ctg aag gag aac cca gtt gac ttg cct gcc aca gag caa aag gag     1351
 Ala Leu Lys Glu Asn Pro Val Asp Leu Pro Ala Thr Glu Gln Lys Glu
     340                 345                 350

 tga gtgg aacagagttg cttcttacta ggagcacatt ctttgcctgc cttcccttca     1408
 


 tcctatcctc tttgcttgct ctcacctcag gaattgcttg gattgctaca tggaccccct   1468

 gagactatca ttattacctc ctagggccag gaagccaggt aggtagtctg agtcaggatt   1528

 ggatcaacag cctcctctct tggggactct caagagcctg tgttcatcta gaagtagtag   1588

 tttgattctg gtttccctcc tacagtgtgt cctccgtctc tgtgcagctc cgtcattacc   1648

 ataggggact tggttttaga ctctgatgag gaagaaaatg gccaggggga aggaaaggtg   1708

 agtgggaagg agcagaaagc tgggaaaggg gatgggtaga acaagactga gaaatccaca   1768

 tgcttcagaa ttcagagggt tcagggaatg gtttcggata gtaggctctc cctgctccct   1828

 tctctacagg aatctttgga aaactatcag aagacaaagt ttgacacctt gatacccact   1888

 ctctgtgaat acctaccccc ttctggccac ggtgccatac ctgtttcttc ctgtgactgt   1948

 agagacagtt ctagaccttt gtgatagaac taaaatgctc tctgtactct agtctcctgc   2008

 ctcctcagct ctgcaagtag tttagtagga atgaagtgga agtccaggct tggattgcct   2068

 aactacactg ctaaaaatat ttgtaatcct taataattaa actttggatt tgttaaaaaa   2128

 aaaaaaaaaa                                                          2138




      <210> 56
      <211> 2568
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (399)..(2327)

      <220>
      <221> misc_feature
      <222> (1)...(2568)
      <223> n = a,t,c or g

      <400> 56
 gttcctttga tatcacttat gatcgagtat tcagagccct ggatgggctg agacagaagg     60

 tcctgccgct ccttaaaaca gccattaagg attgtccagt tggcaaagac tggaagctaa    120

 actnccgacc ttgcccacct agactccttt tcctctttca actcaatgga gccctcaagg    180

 tagaacctcc tcggaaccaa gacccagctc atccagacaa gcccaagaaa cattctccca    240

 aaaggaggct gcagcatgcc ctggaggacc agatctatag aatcttccgg aagagtcgtg    300

 tcttgactaa tcagagcatc aactgcctct ttactgtgcc tgccaaccaa gctttcgtgt    360

 acatagtacc gggaagccag gaggaggacc cagtaggt    atg ttg ctg gac caa     413
                                              Met Leu Leu Asp Gln
                                                1               5

 ctt agg agt cat tgt act gtg aag gac ccg gaa tct ttg ctg gtg cct      461
 Leu Arg Ser His Cys Thr Val Lys Asp Pro Glu Ser Leu Leu Val Pro
                  10                  15                  20

 gca ccc ctt tct ggg cct agg cga tac cag gtg atg agg cag cac agc      509
 Ala Pro Leu Ser Gly Pro Arg Arg Tyr Gln Val Met Arg Gln His Ser
              25                  30                  35

 cga caa caa ctt tcc ttt cac att gac agc agc agt tcc agt tct tca      557
 Arg Gln Gln Leu Ser Phe His Ile Asp Ser Ser Ser Ser Ser Ser Ser
          40                  45                  50

 ggc cag cta gtg gat ttc act ctt cgg gaa ttc cta tgg cag cat gtg      605
 Gly Gln Leu Val Asp Phe Thr Leu Arg Glu Phe Leu Trp Gln His Val
      55                  60                  65

 gag cta gtt cta agc aag aaa ggt ttc gat gac agt gtg ggc agg aac      653
 Glu Leu Val Leu Ser Lys Lys Gly Phe Asp Asp Ser Val Gly Arg Asn
  70                  75                  80                  85

 cca cag cct tcc cat ttt gaa ctt cct act tat cag aag tgg atc tca      701
 Pro Gln Pro Ser His Phe Glu Leu Pro Thr Tyr Gln Lys Trp Ile Ser
                  90                  95                 100

 gca gct tca aaa ctg tat gag gtg gct att gat ggg aaa gaa gag gac      749
 Ala Ala Ser Lys Leu Tyr Glu Val Ala Ile Asp Gly Lys Glu Glu Asp
             105                 110                 115

 ttg ggg tca ccc act gga gag cta aca tct aag att tta agc agt att      797
 Leu Gly Ser Pro Thr Gly Glu Leu Thr Ser Lys Ile Leu Ser Ser Ile
         120                 125                 130

 aaa gtc ttg gaa gga ttt ttg gat att gac aca aaa ttc tca gaa aac      845
 Lys Val Leu Glu Gly Phe Leu Asp Ile Asp Thr Lys Phe Ser Glu Asn
     135                 140                 145

 cga tgc caa aaa gct tta ccc atg gcc cac agt gcc tac cag tca aat      893
 Arg Cys Gln Lys Ala Leu Pro Met Ala His Ser Ala Tyr Gln Ser Asn
 150                 155                 160                 165

 ttg cct cat aat tac aca atg act gtc cat aag aat cag ctt gcc cag      941
 Leu Pro His Asn Tyr Thr Met Thr Val His Lys Asn Gln Leu Ala Gln
                 170                 175                 180

 gct ctt cga gtg tac agt caa cat gct aga ggt cca gca ttt cac aaa      989
 Ala Leu Arg Val Tyr Ser Gln His Ala Arg Gly Pro Ala Phe His Lys
             185                 190                 195

 tac gcc atg cag tta cat gag gac tgc tac aaa ttt tgg agc aat ggc     1037
 Tyr Ala Met Gln Leu His Glu Asp Cys Tyr Lys Phe Trp Ser Asn Gly
         200                 205                 210

 cat cag ctc tgt gag gag agg agt tta act gat caa cac tgt gtg cac     1085
 His Gln Leu Cys Glu Glu Arg Ser Leu Thr Asp Gln His Cys Val His
     215                 220                 225

 aaa ttt cac tca tta cct aaa tca gga gaa aaa cca gag gct gat aga     1133
 Lys Phe His Ser Leu Pro Lys Ser Gly Glu Lys Pro Glu Ala Asp Arg
 230                 235                 240                 245

 aat ccg cct gtg cta tat cac aat agc cga gct cga tct act ggt gct     1181
 Asn Pro Pro Val Leu Tyr His Asn Ser Arg Ala Arg Ser Thr Gly Ala
                 250                 255                 260

 tgc aac tgt gga agg aaa caa gca cct cga gat gat ccc ttt gat atc     1229
 Cys Asn Cys Gly Arg Lys Gln Ala Pro Arg Asp Asp Pro Phe Asp Ile
             265                 270                 275

 aaa gca gcc aat tat gac ttc tat cag ctt ctg gaa gaa aag tgt tgt     1277
 Lys Ala Ala Asn Tyr Asp Phe Tyr Gln Leu Leu Glu Glu Lys Cys Cys
         280                 285                 290

 gga aaa ttg gat cat atc aat ttc cca gta ttt gaa cca agt act cca     1325
 Gly Lys Leu Asp His Ile Asn Phe Pro Val Phe Glu Pro Ser Thr Pro
     295                 300                 305

 gat cct gct cct gct aaa aat gaa tcc tct cct gct cct cca gat tcg     1373
 Asp Pro Ala Pro Ala Lys Asn Glu Ser Ser Pro Ala Pro Pro Asp Ser
 310                 315                 320                 325

 gat gct gat aaa ctt aaa gaa aaa gaa cct caa acc caa gga gag agc     1421
 Asp Ala Asp Lys Leu Lys Glu Lys Glu Pro Gln Thr Gln Gly Glu Ser
                 330                 335                 340

 acg agc ctg agt tta gct ttg agt ttg ggc caa tcc aca gat agc tta     1469
 Thr Ser Leu Ser Leu Ala Leu Ser Leu Gly Gln Ser Thr Asp Ser Leu
             345                 350                 355

 ggt acc tat cca gct gat cca caa gca gga gga gat aat cca gaa gtt     1517
 Gly Thr Tyr Pro Ala Asp Pro Gln Ala Gly Gly Asp Asn Pro Glu Val
         360                 365                 370

 cat ggt caa gta gaa gtg aaa act gag aag agg cca aac ttc gtt gat     1565
 His Gly Gln Val Glu Val Lys Thr Glu Lys Arg Pro Asn Phe Val Asp
     375                 380                 385

 cga cag gca tcc aca gtt gag tat ctc cca ggc atg cta cat tca aat     1613
 Arg Gln Ala Ser Thr Val Glu Tyr Leu Pro Gly Met Leu His Ser Asn
 390                 395                 400                 405

 tgc cct aaa ggt ctc cta ccc aaa ttc tcc agc tgg tct ttg gtt aaa     1661
 Cys Pro Lys Gly Leu Leu Pro Lys Phe Ser Ser Trp Ser Leu Val Lys
                 410                 415                 420

 cta ggc cct gct aag tct tat aac ttt cat aca ggt ttg gac caa cag     1709
 Leu Gly Pro Ala Lys Ser Tyr Asn Phe His Thr Gly Leu Asp Gln Gln
             425                 430                 435

 ggc ttt att cca gga aca aat tat ctt atg cct tgg gac att gtc atc     1757
 Gly Phe Ile Pro Gly Thr Asn Tyr Leu Met Pro Trp Asp Ile Val Ile
         440                 445                 450

 agg act aga gct gaa gat gaa gga gac tta gac aca aac tct tgg cct     1805
 Arg Thr Arg Ala Glu Asp Glu Gly Asp Leu Asp Thr Asn Ser Trp Pro
     455                 460                 465

 gct cca aat aaa gct att cct gga aag aga agt gcg gtt gta atg gga     1853
 Ala Pro Asn Lys Ala Ile Pro Gly Lys Arg Ser Ala Val Val Met Gly
 470                 475                 480                 485

 aga gga aga cgg cga gat gac ata gct cga gct ttt gtg ggc ttt gaa     1901
 Arg Gly Arg Arg Arg Asp Asp Ile Ala Arg Ala Phe Val Gly Phe Glu
                 490                 495                 500

 tat gaa gac tct cga ggt cgg aga ttc atg tgc tct ggg cct gac aaa     1949
 Tyr Glu Asp Ser Arg Gly Arg Arg Phe Met Cys Ser Gly Pro Asp Lys
             505                 510                 515

 gta atg aaa gta atg gga agt ggg cca aag gaa tca gct tta aaa gcc     1997
 Val Met Lys Val Met Gly Ser Gly Pro Lys Glu Ser Ala Leu Lys Ala
         520                 525                 530

 cta aat agt gac atg ccc tta tat att ctg tca tcc tct caa ggt aga     2045
 Leu Asn Ser Asp Met Pro Leu Tyr Ile Leu Ser Ser Ser Gln Gly Arg
     535                 540                 545

 ggg ctg aaa cct cat tat gct caa ctt atg agg ctt ttt gtt gtg gtt     2093
 Gly Leu Lys Pro His Tyr Ala Gln Leu Met Arg Leu Phe Val Val Val
 550                 555                 560                 565

 cct gat gct cct ttg cag ata ata cta atg cct cag gtt cag cca ggc     2141
 Pro Asp Ala Pro Leu Gln Ile Ile Leu Met Pro Gln Val Gln Pro Gly
                 570                 575                 580

 cca cca cca tgt ccg gta ttc tac cca gaa aaa caa gaa atc acc ctt     2189
 Pro Pro Pro Cys Pro Val Phe Tyr Pro Glu Lys Gln Glu Ile Thr Leu
             585                 590                 595

 cca cct gat ggc ctt tgg gtt ttg aga ttt cct tat gca tat gtg act     2237
 Pro Pro Asp Gly Leu Trp Val Leu Arg Phe Pro Tyr Ala Tyr Val Thr
         600                 605                 610

 gag aga gga cct tgt ttc ccc cct aag gaa aat gtg cag tta atg agc     2285
 Glu Arg Gly Pro Cys Phe Pro Pro Lys Glu Asn Val Gln Leu Met Ser
     615                 620                 625

 tac aag gtg ctc cgt ggg gtt ctt aag gca gta aca caa taa gtgtttt     2334
 Tyr Lys Val Leu Arg Gly Val Leu Lys Ala Val Thr Gln 
 630                 635                 640

 ccagccagtt caatcctata cttgagctgg tttttgtttt tggtatttgt ggctgtgttt   2394

 ttggtatgtg tttactgtgt tttcccaaat ccaaaatgtg ttttggttac aggagttcag   2454

 tatttggaaa ctaatttgtt ctactttttc attatattgt tgatatttat tgtaaacgtg   2514

 actacaactt tctaataaag attggttgtt ctagaaaaga atataaaaaa aaaa         2568




      <210> 57
      <211> 1878
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(1280)

      <400> 57
 ctgaggactc cggacactgc ccatctctaa gataagaacc tggaaagggg actctgttgg     60

 ccattggaaa ttgcagaata    atg tct cag gtg aca ttt agt gat gtg gct     110
                          Met Ser Gln Val Thr Phe Ser Asp Val Ala
                            1               5                  10

 ata gac ttc tct cat gaa gag tgg gca tgc cta gat tct gct cag agg      158
 Ile Asp Phe Ser His Glu Glu Trp Ala Cys Leu Asp Ser Ala Gln Arg
                  15                  20                  25

 gac tta tac aag gat gtg atg gtc cag aat tat gag aac ctg gtc tct      206
 Asp Leu Tyr Lys Asp Val Met Val Gln Asn Tyr Glu Asn Leu Val Ser
              30                  35                  40

 gta ggt ctt tcc gta act aag cca tat gtg atc atg tta ttg gag gat      254
 Val Gly Leu Ser Val Thr Lys Pro Tyr Val Ile Met Leu Leu Glu Asp
          45                  50                  55

 gga aaa gag ccc tgg atg atg gag aaa aaa ctg tca aaa gat tgg gaa      302
 Gly Lys Glu Pro Trp Met Met Glu Lys Lys Leu Ser Lys Asp Trp Glu
      60                  65                  70

 tca aga tgg gaa aac aag gaa tta tca aca aag aag gat att tat gat      350
 Ser Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Ile Tyr Asp
  75                  80                  85                  90

 gaa gat tca ccc caa cca gta aca atg gaa aaa gtt gta aaa caa agt      398
 Glu Asp Ser Pro Gln Pro Val Thr Met Glu Lys Val Val Lys Gln Ser
                  95                 100                 105

 tat gaa ttt tca aat tct aat aag aat ttg gaa tat aca gaa tgc gac      446
 Tyr Glu Phe Ser Asn Ser Asn Lys Asn Leu Glu Tyr Thr Glu Cys Asp
             110                 115                 120

 aca ttt aga agc acc ttt cat tca aag tct act ctt tct gaa cca caa      494
 Thr Phe Arg Ser Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln
         125                 130                 135

 aac aat tct gct gaa ggg aat tca cac aaa tat gat ata tta aag aag      542
 Asn Asn Ser Ala Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys
     140                 145                 150

 aat tta tca aaa aag tca gtt ata aaa agt gag aga ata aat ggt gga      590
 Asn Leu Ser Lys Lys Ser Val Ile Lys Ser Glu Arg Ile Asn Gly Gly
 155                 160                 165                 170

 aag aaa ctt tta aat tct aat aaa agt ggg gca gcc ttc aac cag agc      638
 Lys Lys Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Asn Gln Ser
                 175                 180                 185

 aaa tct ctt acc ctt ccc cag act tgt aat aga gag aaa atc tat aca      686
 Lys Ser Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr
             190                 195                 200

 tgc agt gaa tgt ggg aaa gcc ttt ggc aaa cag tca atc ctc agt cgc      734
 Cys Ser Glu Cys Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Ser Arg
         205                 210                 215

 cac tgg aga att cat aca gga gag aag ccc tat gaa tgt cgt gaa ttt      782
 His Trp Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Phe
     220                 225                 230

 ggg aag act ttt agc cat ggt tca tcc ctt aca cga cat cag ata agc      830
 Gly Lys Thr Phe Ser His Gly Ser Ser Leu Thr Arg His Gln Ile Ser
 235                 240                 245                 250

 cat agt gga gag aaa cct tac aaa tgc att gaa tgt ggg aag gcc ttt      878
 His Ser Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe
                 255                 260                 265

 agc cat ggc tca tca ctt act aac cat cag agc act cac acg gga gag      926
 Ser His Gly Ser Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu
             270                 275                 280

 aaa ccg tat gaa tgt atg aac tgt gga aag tct ttt agt cgt gtg tcc      974
 Lys Pro Tyr Glu Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser
         285                 290                 295

 ctt ctc att cag cat cta aga att cat acg caa gaa aaa cgc tat gag     1022
 Leu Leu Ile Gln His Leu Arg Ile His Thr Gln Glu Lys Arg Tyr Glu
     300                 305                 310

 tgt cgt ata tgt gga aag gcc ttc att cat agt tcg tct ctc att cac     1070
 Cys Arg Ile Cys Gly Lys Ala Phe Ile His Ser Ser Ser Leu Ile His
 315                 320                 325                 330

 cat cag aaa agc cat act gga gag aag cct tat gaa tgt aga gaa tgt     1118
 His Gln Lys Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys
                 335                 340                 345

 ggg aaa gct ttc tgc tgt agc tca cac ctt act caa cat caa aga att     1166
 Gly Lys Ala Phe Cys Cys Ser Ser His Leu Thr Gln His Gln Arg Ile
             350                 355                 360

 cac agt atg aag aaa aaa tat gaa tgc aac aaa tgt ctc aag gtc ttt     1214
 His Ser Met Lys Lys Lys Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe
         365                 370                 375

 agt agc ttc tca ttt ctt gtt caa cat cag agt att cat act gaa gaa     1262
 Ser Ser Phe Ser Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu
     380                 385                 390

 aaa ccg ttt gaa gtt tag aaatgc aggaaatcct tcaaccagct tgaatcactg     1316
 Lys Pro Phe Glu Val 
 395

 aatatgcatt tgagaaatca cattagattg aaaccctacg aatgcagtat atgtgggaaa   1376

 gcctttagtc ataggtcgtc cctgcttcaa catcacagta ttcatactgg agagaaacct   1436

 tacgaatgta ttaaatgtgg gaagaccttc agctgtagtt caaaccttac tgtacatcag   1496

 agaattcata ctggagaaaa gccatataaa tgtagtgagt gtgggaaagc ttttagcaaa   1556

 ggctcgaatc ttactgccca tcaaagagta cataatggag agaaacccaa tagtgtggta   1616

 agtgtggaaa agcctttaga tcatatgaat ccctatacat gtgagaaatc ttacagaaga   1676

 gaagcagtgt ttatcacggt aaacttcatt catagatcct cccttattta acatcagaaa   1736

 aatgtatact ggggaaaagt tgtatgaagg tggtgaacat gggagacttt tagcaatgat   1796

 gcagattttt ttattagagt ttatactgta gagaaatcat atgaagtcaa taaatgtggg   1856

 aaagccttaa aaaaaaaaaa aa                                            1878




      <210> 58
      <211> 1464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(985)

      <400> 58
 accccacttc cggaatcgac gattccgtgt gggctgtcgc actggaggaa gggaaccctc     60

 caccctgaga tctctgtctc tatcctatcc tgtccctggc cttctgaggc aagcggggcc    120

 aattaagggg aaaacgtacc tccctccatt tgtgctgaac caacccctcc aacccctctc    180

 aggagggcat gat   atg gag agt tgg gca ttg gct gtg ttc cct gaa tac     229
                  Met Glu Ser Trp Ala Leu Ala Val Phe Pro Glu Tyr
                    1               5                  10

 aga gta tct ctc ttg tgg tgc ctg gaa ctg gca tcc cct ttg tgg agc      277
 Arg Val Ser Leu Leu Trp Cys Leu Glu Leu Ala Ser Pro Leu Trp Ser
          15                  20                  25

 tta ggg caa gcc ccg cct ctg cat gag act tgg ttt gtg gga cac act      325
 Leu Gly Gln Ala Pro Pro Leu His Glu Thr Trp Phe Val Gly His Thr
      30                  35                  40

 tgg ttt cag gga agg gga aag agg tca cca agg gca gag gtg tcc agg      373
 Trp Phe Gln Gly Arg Gly Lys Arg Ser Pro Arg Ala Glu Val Ser Arg
  45                  50                  55                  60

 ccg gag cca ggg gcc cca ctg ttg gga tgc tgg ctg cag tgg ggc gcc      421
 Pro Glu Pro Gly Ala Pro Leu Leu Gly Cys Trp Leu Gln Trp Gly Ala
                  65                  70                  75

 cca agc cca ggt ccc ctc tgt ctt ctc ttt cga ctt tgc agc tgt act      469
 Pro Ser Pro Gly Pro Leu Cys Leu Leu Phe Arg Leu Cys Ser Cys Thr
              80                  85                  90

 tgt ttt gct cct cta ccc gca gga gct gac atg gac cca aat cct cgg      517
 Cys Phe Ala Pro Leu Pro Ala Gly Ala Asp Met Asp Pro Asn Pro Arg
          95                 100                 105

 gcc gcc ctg gag cgc cag cag ctc cgc ctt cgg gag cgg caa aaa ttc      565
 Ala Ala Leu Glu Arg Gln Gln Leu Arg Leu Arg Glu Arg Gln Lys Phe
     110                 115                 120

 ttc gag gac att tta cag cca gag aca gag ttt gtc ttt cct ctg tcc      613
 Phe Glu Asp Ile Leu Gln Pro Glu Thr Glu Phe Val Phe Pro Leu Ser
 125                 130                 135                 140

 cat ctg cat ctc gag tcg cag aga ccc ccc ata ggt agt atc tca tcc      661
 His Leu His Leu Glu Ser Gln Arg Pro Pro Ile Gly Ser Ile Ser Ser
                 145                 150                 155

 atg gaa gtg aat gtg gac aca ctg gag caa gta gaa ctt att gac ctt      709
 Met Glu Val Asn Val Asp Thr Leu Glu Gln Val Glu Leu Ile Asp Leu
             160                 165                 170

 ggg gac ccg gat gca gca gat gtg ttc ttg cct tgc gaa gat cct cca      757
 Gly Asp Pro Asp Ala Ala Asp Val Phe Leu Pro Cys Glu Asp Pro Pro
         175                 180                 185

 cca acc ccc cag tcg tct ggg gtg gac aac cat ttg gag gag ctg agc      805
 Pro Thr Pro Gln Ser Ser Gly Val Asp Asn His Leu Glu Glu Leu Ser
     190                 195                 200

 ctg ccg gtg gct aca tca gac agg acc aca tct agg acc tcc tcc tcc      853
 Leu Pro Val Ala Thr Ser Asp Arg Thr Thr Ser Arg Thr Ser Ser Ser
 205                 210                 215                 220

 tcc tcc tcc gac tcc tcc acc aac ctg cat agc cca aat cca agt gat      901
 Ser Ser Ser Asp Ser Ser Thr Asn Leu His Ser Pro Asn Pro Ser Asp
                 225                 230                 235

 gat gga gca gat acg ccc ttg gca cag tcg gat gaa gag gag gaa agg      949
 Asp Gly Ala Asp Thr Pro Leu Ala Gln Ser Asp Glu Glu Glu Glu Arg
             240                 245                 250

 ggt gat gga ggg gca gag cct gga gcc tgc agc tag cagt gggcccctgc      999
 Gly Asp Gly Gly Ala Glu Pro Gly Ala Cys Ser 
         255                 260

 ctacagactg accacgctgg ctattctcca catgagacca caggcccagc cagagcctgt   1059

 cgggagaaga ccagactctt tacttgcagt aggcaccaga ggtgggaagg atggtgggat   1119

 tgtgtacctt tctaagaatt aaccctctcc tgctttactg ctaatttttt cctgctgcaa   1179

 ccctcccacc agtttttggc ttactcctga gatatgattt gcaaatgagg agagagaaga   1239

 tgaggttgga caagatgcca ctgcttttct tagcactctt ccctccccta aaccatcccg   1299

 tagtcttcta atacagtctc tcagacaagt gtctctagat ggatgtgaac tccttaactc   1359

 atcaagtaag gtggtactca agccatgctg cctccttaca tcctttttgg aacagagcac   1419

 ggtataaata ataaactaat aataatatgc caaaaaaaaa aaaaa                   1464




      <210> 59
      <211> 1996
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1220)

      <400> 59
 atctg    atg gat aat cca act ttt gca gaa gat gag gag tta caa aat      47
          Met Asp Asn Pro Thr Phe Ala Glu Asp Glu Glu Leu Gln Asn
            1               5                  10

 atg gac aaa gaa gat gca tta att tgc ttt gaa gaa cac att cgg gct       95
 Met Asp Lys Glu Asp Ala Leu Ile Cys Phe Glu Glu His Ile Arg Ala
  15                  20                  25                  30

 tta gaa aag gag gaa gaa gaa gaa aaa cag aag agt ttg ctg aga gaa      143
 Leu Glu Lys Glu Glu Glu Glu Glu Lys Gln Lys Ser Leu Leu Arg Glu
                  35                  40                  45

 agg aga cga cag cga aaa aat agg gaa tct ttc cag ata ttt tta gat      191
 Arg Arg Arg Gln Arg Lys Asn Arg Glu Ser Phe Gln Ile Phe Leu Asp
              50                  55                  60

 gaa tta cat gaa cat gga caa ctg cat tct atg tca tct tgg atg gaa      239
 Glu Leu His Glu His Gly Gln Leu His Ser Met Ser Ser Trp Met Glu
          65                  70                  75

 ttg tat cca act att agt tct gat att aga ttc act aat atg ctt ggt      287
 Leu Tyr Pro Thr Ile Ser Ser Asp Ile Arg Phe Thr Asn Met Leu Gly
      80                  85                  90

 cag cct gtt ttt tca tta gga tca act gca ctt gat ctt ttc aag ttt      335
 Gln Pro Val Phe Ser Leu Gly Ser Thr Ala Leu Asp Leu Phe Lys Phe
  95                 100                 105                 110

 tat gtt gag gat ctt aaa gca cgt tat cat gac gag aag aag ata ata      383
 Tyr Val Glu Asp Leu Lys Ala Arg Tyr His Asp Glu Lys Lys Ile Ile
                 115                 120                 125

 aaa gac att cta aag gat aaa gga ttt gta gtt gaa gta aac act act      431
 Lys Asp Ile Leu Lys Asp Lys Gly Phe Val Val Glu Val Asn Thr Thr
             130                 135                 140

 ttt gaa gat ttt gtg gcg ata atc agt tca act aaa aga tca act aca      479
 Phe Glu Asp Phe Val Ala Ile Ile Ser Ser Thr Lys Arg Ser Thr Thr
         145                 150                 155

 tta gat gct gga aat atc aaa ttg gct ttc aat agt tta cta gaa aag      527
 Leu Asp Ala Gly Asn Ile Lys Leu Ala Phe Asn Ser Leu Leu Glu Lys
     160                 165                 170

 gca gaa gcc cgt gaa cgt gaa aga gaa aaa gaa gag gct cgg aag atg      575
 Ala Glu Ala Arg Glu Arg Glu Arg Glu Lys Glu Glu Ala Arg Lys Met
 175                 180                 185                 190

 aaa cga aaa gaa tct gca ttt aag agt atg tta aaa caa gct gct cct      623
 Lys Arg Lys Glu Ser Ala Phe Lys Ser Met Leu Lys Gln Ala Ala Pro
                 195                 200                 205

 ccg ata gaa ttg gat gct gtc tgg gaa gat atc cgt gag aga ttt gta      671
 Pro Ile Glu Leu Asp Ala Val Trp Glu Asp Ile Arg Glu Arg Phe Val
             210                 215                 220

 aaa gag cca gca ttt gag gac ata act cta gaa tct gaa aga aaa cga      719
 Lys Glu Pro Ala Phe Glu Asp Ile Thr Leu Glu Ser Glu Arg Lys Arg
         225                 230                 235

 ata ttt aaa gat ttt atg cat gtg ctt gag cat gaa tgt cag cat cat      767
 Ile Phe Lys Asp Phe Met His Val Leu Glu His Glu Cys Gln His His
     240                 245                 250

 cat tca aag aac aag aaa cat tct aag aaa tct aaa aaa cat cat agg      815
 His Ser Lys Asn Lys Lys His Ser Lys Lys Ser Lys Lys His His Arg
 255                 260                 265                 270

 aaa cgt tcc cgc tct cga tcg ggg tca gat tca gat gat gat gat agc      863
 Lys Arg Ser Arg Ser Arg Ser Gly Ser Asp Ser Asp Asp Asp Asp Ser
                 275                 280                 285

 cat tca aag aaa aaa aga cag cga tca gag tct cgt tct gct tca gaa      911
 His Ser Lys Lys Lys Arg Gln Arg Ser Glu Ser Arg Ser Ala Ser Glu
             290                 295                 300

 cat tct tct agt gca gag tct gag aga agt tat aaa aag tca aaa aag      959
 His Ser Ser Ser Ala Glu Ser Glu Arg Ser Tyr Lys Lys Ser Lys Lys
         305                 310                 315

 cat aag aag aaa agt aag aag agg aga cat aaa tct gac tct cca gaa     1007
 His Lys Lys Lys Ser Lys Lys Arg Arg His Lys Ser Asp Ser Pro Glu
     320                 325                 330

 tcc gat gct gag cga gag aag gat aaa aaa gaa aaa gat cgg gaa agt     1055
 Ser Asp Ala Glu Arg Glu Lys Asp Lys Lys Glu Lys Asp Arg Glu Ser
 335                 340                 345                 350

 gaa aaa gac aga act aga caa aga tca gaa tca aaa cac aaa tcg cct     1103
 Glu Lys Asp Arg Thr Arg Gln Arg Ser Glu Ser Lys His Lys Ser Pro
                 355                 360                 365

 aag aaa aag act gga aag gat tct ggt aat tgg gat act tct ggc agc     1151
 Lys Lys Lys Thr Gly Lys Asp Ser Gly Asn Trp Asp Thr Ser Gly Ser
             370                 375                 380

 gaa ctg agt gaa ggg gaa ttg gaa aag cgc aga aga acc ctt ttg gag     1199
 Glu Leu Ser Glu Gly Glu Leu Glu Lys Arg Arg Arg Thr Leu Leu Glu
         385                 390                 395

 caa ctg gat gat gat caa taa at tataccaaat atatgtttac agtatgattt     1252
 Gln Leu Asp Asp Asp Gln 
     400

 aaagtctgat tcagaccagg gactctattt taagttcaac tgaaataaca ctgggtttta   1312

 attatatcac aggaaaaaaa aagtgcattt aagtattgtt atcgtggact ttataaaagc   1372

 aaaggaaatt gaaagtaact tttgattctg tatcaagaat catattttca tacagtcata   1432

 actgtctttc tgtgaccctt tcacagggca ctgtaggatg gattaaaggt ggcaatttac   1492

 tgataactgc agatgtctct actttgttct aaaatctaag tcatgaggtg atttgattta   1552

 ctttatagaa gctggatttt gaagatctaa tgaaaaattt tttgataata tagtagtaca   1612

 aaaaaagcac cagcaactga taaaaattgc ttttttgtgc gctacccaac tggttaaagc   1672

 caatgtgatc ttttatggtg aaactcctaa gaaacaggtg gttttgctgg aaacttggta   1732

 gacccttaat tatagtggtg ctaatgagca ctactgtaat ataaagccac cattattttt   1792

 tatcaaacat ctgaatacat tttacaaagg ctattgtgag ggcattattt tgagcatcta   1852

 ttttgaggtg atgtttaaaa aaactttaac atcaaatcaa attgtaaatt aatttaaata   1912

 tattgcctta aggacctact aaagaatgtg ccaccagact ttaagtgata gttgcaatat   1972

 ccttgtctaa aaaaaaaaaa aaaa                                          1996




      <210> 60
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(876)

      <400> 60
 aaggatcctt aattaaattt atctcccccc cccttcccgg ggtcagtgcc gtagcgcccg     60

 gctcctgcag gcgctcggcc tccgctcatt cctgaccccg cagtgggcgc g atg gcg     117
                                                          Met Ala
                                                            1

 gag gct gta ctg agg gtc gcc cgg cgg cag ctg agc cag cgc ggc ggg      165
 Glu Ala Val Leu Arg Val Ala Arg Arg Gln Leu Ser Gln Arg Gly Gly
           5                  10                  15

 tct gga gcc ccc atc ctc ctg cgg cag atg ttc gag cct gtg agc tgc      213
 Ser Gly Ala Pro Ile Leu Leu Arg Gln Met Phe Glu Pro Val Ser Cys
      20                  25                  30

 acc ttc acg tac ctg ctg ggt gac aga gag tcc cgg gag gcc gtt ctg      261
 Thr Phe Thr Tyr Leu Leu Gly Asp Arg Glu Ser Arg Glu Ala Val Leu
  35                  40                  45                  50

 atc gac cca gtc ctg gaa aca gcg cct cgg gat gcc cag ctg atc aag      309
 Ile Asp Pro Val Leu Glu Thr Ala Pro Arg Asp Ala Gln Leu Ile Lys
                  55                  60                  65

 gag ctg ggg ctg cgg ctg ctc tat gct gtg aat acc cac tgc cac gcg      357
 Glu Leu Gly Leu Arg Leu Leu Tyr Ala Val Asn Thr His Cys His Ala
              70                  75                  80

 gac cac att aca ggc tcg ggg ctg ctc cgt tcc ctc ctc cct ggc tgc      405
 Asp His Ile Thr Gly Ser Gly Leu Leu Arg Ser Leu Leu Pro Gly Cys
          85                  90                  95

 cag tct gtc atc tcc cgc ctt agt ggg gcc cag gct gac tta cac att      453
 Gln Ser Val Ile Ser Arg Leu Ser Gly Ala Gln Ala Asp Leu His Ile
     100                 105                 110

 gag gat gga gac tcc atc cgc ttc ggg cgc ttc gcg ttg gag acc agg      501
 Glu Asp Gly Asp Ser Ile Arg Phe Gly Arg Phe Ala Leu Glu Thr Arg
 115                 120                 125                 130

 gcc agc cct ggc cac acc cca ggc tgt gtc acc ttc gtc ctg aat gac      549
 Ala Ser Pro Gly His Thr Pro Gly Cys Val Thr Phe Val Leu Asn Asp
                 135                 140                 145

 cac agc atg gcc ttc act gga gat gcc ctg ttg atc cgt ggg tgt ggg      597
 His Ser Met Ala Phe Thr Gly Asp Ala Leu Leu Ile Arg Gly Cys Gly
             150                 155                 160

 cgg aca gac ttc cag caa ggc tgt gcc aag acc ttg tac cac tcg gtc      645
 Arg Thr Asp Phe Gln Gln Gly Cys Ala Lys Thr Leu Tyr His Ser Val
         165                 170                 175

 cat gaa aag atc ttc aca ctt cca gga gac tgt ctg atc tac cct gct      693
 His Glu Lys Ile Phe Thr Leu Pro Gly Asp Cys Leu Ile Tyr Pro Ala
     180                 185                 190

 cac gat tac cat ggg ttc aca gtg tcc acc gtg gag gag gag agg act      741
 His Asp Tyr His Gly Phe Thr Val Ser Thr Val Glu Glu Glu Arg Thr
 195                 200                 205                 210

 ctg aac cct cgg ctc acc ctc agc tgt gag gag ttt gtc aaa atc atg      789
 Leu Asn Pro Arg Leu Thr Leu Ser Cys Glu Glu Phe Val Lys Ile Met
                 215                 220                 225

 ggc aac ctg aac ttg cct aaa cct cag cag ata gac ttt gct gtt cca      837
 Gly Asn Leu Asn Leu Pro Lys Pro Gln Gln Ile Asp Phe Ala Val Pro
             230                 235                 240

 gcc aac atg cgc tgt ggg gtg cag aca ccc act gcc tga tctcacttct       886
 Ala Asn Met Arg Cys Gly Val Gln Thr Pro Thr Ala 
         245                 250

 gtcagatgct cccatccact attaatgcac taggtgggag gagagggcgg caatgacact    946

 gcacctctcc tttcccaccg cattccctgg agctccctaa ataaaacttt ttttaacgtg   1006

 aaaaaaaaaa aaa                                                      1019




      <210> 61
      <211> 2388
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1414)

      <400> 61
 ggcggcc  atg gag acc gag acg gcg ccg ctg acc cta gag tcg ctg ccc      49
          Met Glu Thr Glu Thr Ala Pro Leu Thr Leu Glu Ser Leu Pro
            1               5                  10

 acc gat ccc ctg ctc ctc atc tta tcc ttt ttg gac tat cgg gat cta       97
 Thr Asp Pro Leu Leu Leu Ile Leu Ser Phe Leu Asp Tyr Arg Asp Leu
  15                  20                  25                  30

 atc aac tgt tgt tat gtc agt cga aga ctt agc cag cta tca agt cat      145
 Ile Asn Cys Cys Tyr Val Ser Arg Arg Leu Ser Gln Leu Ser Ser His
                  35                  40                  45

 gat ccg ctg tgg aga aga cat tgc aaa aaa tac tgg ctg ata tct gag      193
 Asp Pro Leu Trp Arg Arg His Cys Lys Lys Tyr Trp Leu Ile Ser Glu
              50                  55                  60

 gaa gag aaa aca cag aag aat cag tgt tgg aaa tct ctc ttc ata gat      241
 Glu Glu Lys Thr Gln Lys Asn Gln Cys Trp Lys Ser Leu Phe Ile Asp
          65                  70                  75

 act tac tct gat gta gga aga tac att gac cat tat gct gct att aaa      289
 Thr Tyr Ser Asp Val Gly Arg Tyr Ile Asp His Tyr Ala Ala Ile Lys
      80                  85                  90

 aag gcc tgg gat gat ctc aag aaa tat ttg gag ccc agg tgt cct cgg      337
 Lys Ala Trp Asp Asp Leu Lys Lys Tyr Leu Glu Pro Arg Cys Pro Arg
  95                 100                 105                 110

 atg gtt tta tct ctg aaa gag ggt gct cga gag gaa gac ctc gat gct      385
 Met Val Leu Ser Leu Lys Glu Gly Ala Arg Glu Glu Asp Leu Asp Ala
                 115                 120                 125

 gtg gaa gcg cag att ggc tgc aag ctt cct gac gat tat cga tgt tca      433
 Val Glu Ala Gln Ile Gly Cys Lys Leu Pro Asp Asp Tyr Arg Cys Ser
             130                 135                 140

 tac cga att cac aat gga cag aag tta gtg gtt cct ggg tta ttg gga      481
 Tyr Arg Ile His Asn Gly Gln Lys Leu Val Val Pro Gly Leu Leu Gly
         145                 150                 155

 agc atg gca ctg tct aat cac tat cgt tct gaa gat ttg tta gac gtc      529
 Ser Met Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu Leu Asp Val
     160                 165                 170

 gat aca gct gcc gga gga ttc cag cag aga cag gga ctg aaa tac tgt      577
 Asp Thr Ala Ala Gly Gly Phe Gln Gln Arg Gln Gly Leu Lys Tyr Cys
 175                 180                 185                 190

 ctc cct tta act ttt tgc ata cat act ggt ttg agt cag tac ata gca      625
 Leu Pro Leu Thr Phe Cys Ile His Thr Gly Leu Ser Gln Tyr Ile Ala
                 195                 200                 205

 gtg gaa gct gca gag ggc cga aac aaa aat gaa gtt ttc tac caa tgt      673
 Val Glu Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe Tyr Gln Cys
             210                 215                 220

 cca gac caa atg gct cga aat cca gct gct att gac atg ttt att ata      721
 Pro Asp Gln Met Ala Arg Asn Pro Ala Ala Ile Asp Met Phe Ile Ile
         225                 230                 235

 ggt gct act ttt act gac tgg ttt acc tct tat gtc aaa aat gtt gta      769
 Gly Ala Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Lys Asn Val Val
     240                 245                 250

 tca ggt ggc ttc ccc atc atc aga gac caa att ttc aga tat gtt cac      817
 Ser Gly Gly Phe Pro Ile Ile Arg Asp Gln Ile Phe Arg Tyr Val His
 255                 260                 265                 270

 gat cca gaa tgt gta gca aca act ggg gat att act gtg tca gtt tcc      865
 Asp Pro Glu Cys Val Ala Thr Thr Gly Asp Ile Thr Val Ser Val Ser
                 275                 280                 285

 aca tcg ttt ctg cca gaa ctt agc tct gta cat cca ccc cac tat ttc      913
 Thr Ser Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro His Tyr Phe
             290                 295                 300

 ttc aca tac cga atc agg att gaa atg tca aaa gat gca ctt cct gag      961
 Phe Thr Tyr Arg Ile Arg Ile Glu Met Ser Lys Asp Ala Leu Pro Glu
         305                 310                 315

 aag gcc tgt cag ttg gac agt cgc tat tgg aga ata aca aat gct aag     1009
 Lys Ala Cys Gln Leu Asp Ser Arg Tyr Trp Arg Ile Thr Asn Ala Lys
     320                 325                 330

 ggt gac gtg gaa gaa gtt caa gga cct gga gta gtt ggt gaa ttt cca     1057
 Gly Asp Val Glu Glu Val Gln Gly Pro Gly Val Val Gly Glu Phe Pro
 335                 340                 345                 350

 atc atc agc cca ggt cgg gta tat gaa tac aca agc tgt acc aca ttc     1105
 Ile Ile Ser Pro Gly Arg Val Tyr Glu Tyr Thr Ser Cys Thr Thr Phe
                 355                 360                 365

 tct aca aca tca gga tac atg gaa gga tat tat acc ttc cat ttt ctt     1153
 Ser Thr Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe His Phe Leu
             370                 375                 380

 tac ttt aaa gac aag atc ttt aat gtt gcc att ccc cga ttc cat atg     1201
 Tyr Phe Lys Asp Lys Ile Phe Asn Val Ala Ile Pro Arg Phe His Met
         385                 390                 395

 gca tgt cca aca ttc agg gtg tct ata gcc cga ttg gaa atg ggt cct     1249
 Ala Cys Pro Thr Phe Arg Val Ser Ile Ala Arg Leu Glu Met Gly Pro
     400                 405                 410

 gat gaa tat gaa gag atg gaa gaa gag gag gag gag gaa gag gag gaa     1297
 Asp Glu Tyr Glu Glu Met Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
 415                 420                 425                 430

 gac gag gat gat gat tca gca gat atg gat gaa tca gat gaa gat gat     1345
 Asp Glu Asp Asp Asp Ser Ala Asp Met Asp Glu Ser Asp Glu Asp Asp
                 435                 440                 445

 gaa gag gag aga cgg agg aga gtc ttt gat gtt ccc att cgc aga cgc     1393
 Glu Glu Glu Arg Arg Arg Arg Val Phe Asp Val Pro Ile Arg Arg Arg
             450                 455                 460

 cgc tgc tca cgc ctt ttt tag ca agccttctgc tgatggaagc actaggatga     1446
 Arg Cys Ser Arg Leu Phe 
         465

 ttctaggctg ttaaatagat ttctcaataa tgtaaataac taaattgttc tctgcatata   1506

 gcaggaaaac tagcatgaaa tattgtttca ggccctgggt tctatgtgac actacattag   1566

 gaattggatt gtttgggttt gctttgtgtt tttgaggtag aggaagaaat gggaatcttt   1626

 tttttctctt ccaggagtca gtggaagaat agttctctag ctaaggaacg gacatacctt   1686

 tgttttaaaa tattttatac ttacaaaaat ctagaaatgg agagggaact gttttgaata   1746

 aggatttaaa atacctgcac aaggatagag agaaactatg tgactcattc tgtgaaaaga   1806

 cttcttgcag ttgtgagtta tttagaaatg atcaaaattt gtaattaggc taatccattt   1866

 agtgattcct aatattttgt actcacagag aactaattga ctaaacaact tgaacgctag   1926

 tggtttgtcc ttagacaatc tgtctttgaa tttaaagtct ttatcgctaa gaccttgact   1986

 ttaaattttt catcactaca accttgaatt taatttcagg tcttcaacat gatgaccttg   2046

 gatttaattt aaagtcttca acactatgcg ctttatcata ttattcacag atgcattttt   2106

 gaaatgtagt atgtaaaagt atgtaacgtg ctgtttatta acaaaagatt gttcacaaca   2166

 tctcatgtag tttaaatttg taaatactgc ttctgttttg tttctccttt atacacttga   2226

 ctgtctttgt gataagtgac atgaatttta tgttaggatt aagtatgttt tcctgaaact   2286

 tggatttttt ttgtaattat ataattgaga gttaagaatg aaatccttca agtgttaaaa   2346

 actcacattt taaaagcaaa ttttggttcc aaaaaaaaaa aa                      2388




      <210> 62
      <211> 727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(647)

      <400> 62
 tactactact aaattcgcgg ccgcgtcgac gtttgcttag gcgcagacgg ggaagcggag     60

 ccaac    atg cca gtg gcc cgg agc tgg gtt tgt cgc aaa act tat gtg     107
          Met Pro Val Ala Arg Ser Trp Val Cys Arg Lys Thr Tyr Val
            1               5                  10

 acc ccg cgg aga ccc ttc gag aaa tct cgt ctc gac caa gag ctg aag      155
 Thr Pro Arg Arg Pro Phe Glu Lys Ser Arg Leu Asp Gln Glu Leu Lys
  15                  20                  25                  30

 ctg atc ggc gag tat ggg ctc cgg aac aaa cgt gag gtc tgg agg gtc      203
 Leu Ile Gly Glu Tyr Gly Leu Arg Asn Lys Arg Glu Val Trp Arg Val
                  35                  40                  45

 aaa ttt acc ctg gcc aag atc cgc aag gcc gcc cgg gaa ctg ctg acg      251
 Lys Phe Thr Leu Ala Lys Ile Arg Lys Ala Ala Arg Glu Leu Leu Thr
              50                  55                  60

 ctt gat gag aag gac cca cgg cgt ctg ttc gaa ggc aac gcc ctg ctg      299
 Leu Asp Glu Lys Asp Pro Arg Arg Leu Phe Glu Gly Asn Ala Leu Leu
          65                  70                  75

 cgg cgg ctg gtc cgc att ggg gtg ctg gat gag ggc aag atg aag ctg      347
 Arg Arg Leu Val Arg Ile Gly Val Leu Asp Glu Gly Lys Met Lys Leu
      80                  85                  90

 gat tac atc ctg ggc ctg aag ata gag gat ttc tta gag aga cgc ctg      395
 Asp Tyr Ile Leu Gly Leu Lys Ile Glu Asp Phe Leu Glu Arg Arg Leu
  95                 100                 105                 110

 cag acc cag gtc ttc aag ctg ggc ttg gcc aag tcc atc cac gct cgc      443
 Gln Thr Gln Val Phe Lys Leu Gly Leu Ala Lys Ser Ile His Ala Arg
                 115                 120                 125

 gtg ctg atc cgc cag cgc cat atc agg gtc cgc aag cag gtg gtg aac      491
 Val Leu Ile Arg Gln Arg His Ile Arg Val Arg Lys Gln Val Val Asn
             130                 135                 140

 atc ccg tcc ttc att gtc cgc ctg gat tcc cag aag cac atc gac ttc      539
 Ile Pro Ser Phe Ile Val Arg Leu Asp Ser Gln Lys His Ile Asp Phe
         145                 150                 155

 tct ctg cgc tct ccc tac ggg ggt ggc cgc ccg ggc cgc gtg aag agg      587
 Ser Leu Arg Ser Pro Tyr Gly Gly Gly Arg Pro Gly Arg Val Lys Arg
     160                 165                 170

 aag aat gcc aag aag ggc cag ggt ggg gct ggg gct gga gac gac gag      635
 Lys Asn Ala Lys Lys Gly Gln Gly Gly Ala Gly Ala Gly Asp Asp Glu
 175                 180                 185                 190

 gag gag gat taa gtc cacctgtccc tcctgggctg ctggattgtc tcgttttccc      690
 Glu Glu Asp 


 gccaaataaa caggatcagc gctttaaaaa aaaaaaa                             727




      <210> 63
      <211> 1300
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1218)

      <400> 63
 cccacgcgtc cggctacgtg tgttgccata gcgaccattt tgcattaact ggttggtagc     60

 ttctatcctg ggggctgagc gactgcgggc cagctcttcc cctactccct ctcggctcct    120

 tgtggcccaa aggcctaacc ggggtccggc ggtctggcct agggatcttc cccgttgccc    180

 ctttggggcg gg    atg gct gcg gaa gaa gaa gac gag gtg gag tgg gta     228
                  Met Ala Ala Glu Glu Glu Asp Glu Val Glu Trp Val
                    1               5                  10

 gtg gag agc atc gcg ggg ttc ctg cga ggc cca gac tgg tcc atc ccc      276
 Val Glu Ser Ile Ala Gly Phe Leu Arg Gly Pro Asp Trp Ser Ile Pro
          15                  20                  25

 atc ttg gac ttt gtg gaa cag aaa tgt gaa gtt ttt gat gat gaa gaa      324
 Ile Leu Asp Phe Val Glu Gln Lys Cys Glu Val Phe Asp Asp Glu Glu
      30                  35                  40

 gaa agc aaa ttg acc tat aca gag att cat cag gaa tac aaa gaa cta      372
 Glu Ser Lys Leu Thr Tyr Thr Glu Ile His Gln Glu Tyr Lys Glu Leu
  45                  50                  55                  60

 gtt gaa aag ctg tta gaa ggt tac ctc aaa gaa att gga att aat gaa      420
 Val Glu Lys Leu Leu Glu Gly Tyr Leu Lys Glu Ile Gly Ile Asn Glu
                  65                  70                  75

 gat caa ttt caa gaa gca tgc act tct cct ctt gca aag acc cat aca      468
 Asp Gln Phe Gln Glu Ala Cys Thr Ser Pro Leu Ala Lys Thr His Thr
              80                  85                  90

 tca cag gcc att ttg caa cct gtg ttg gca gca gaa gat ttt act atc      516
 Ser Gln Ala Ile Leu Gln Pro Val Leu Ala Ala Glu Asp Phe Thr Ile
          95                 100                 105

 ttt aaa gca atg atg gtc cag aaa aac att gaa atg cag ctg caa gcc      564
 Phe Lys Ala Met Met Val Gln Lys Asn Ile Glu Met Gln Leu Gln Ala
     110                 115                 120

 att cga ata att caa gag aga aat ggt gta tta cct gac tgc tta acc      612
 Ile Arg Ile Ile Gln Glu Arg Asn Gly Val Leu Pro Asp Cys Leu Thr
 125                 130                 135                 140

 gat ggc tct gat gtg gtc agt gac ctt gaa cac gaa gag atg aaa atc      660
 Asp Gly Ser Asp Val Val Ser Asp Leu Glu His Glu Glu Met Lys Ile
                 145                 150                 155

 ctg agg gaa gtt ctt aga aaa tca aaa gag gaa tat gac cag gaa gag      708
 Leu Arg Glu Val Leu Arg Lys Ser Lys Glu Glu Tyr Asp Gln Glu Glu
             160                 165                 170

 aaa gga gag gaa aaa cag tta tca gag gct aaa cag aaa gag ccc aca      756
 Lys Gly Glu Glu Lys Gln Leu Ser Glu Ala Lys Gln Lys Glu Pro Thr
         175                 180                 185

 gtg cat tcc agt gaa gct gca ata atg aat aat tcc caa ggg gat ggt      804
 Val His Ser Ser Glu Ala Ala Ile Met Asn Asn Ser Gln Gly Asp Gly
     190                 195                 200

 gaa cat ttt gca cac cca ccc tca gaa gtt aaa atg cat ttt gct aat      852
 Glu His Phe Ala His Pro Pro Ser Glu Val Lys Met His Phe Ala Asn
 205                 210                 215                 220

 cag tca ata gaa cct ttg gga aga aaa gtg gaa agg tct gaa act tcc      900
 Gln Ser Ile Glu Pro Leu Gly Arg Lys Val Glu Arg Ser Glu Thr Ser
                 225                 230                 235

 tcc ctc cca caa aaa ggc ctg aag att cct ggc tta gag cat gcg agc      948
 Ser Leu Pro Gln Lys Gly Leu Lys Ile Pro Gly Leu Glu His Ala Ser
             240                 245                 250

 att gaa gga cca ata gca aac tta tca gta ctt gga aca gaa gaa ctt      996
 Ile Glu Gly Pro Ile Ala Asn Leu Ser Val Leu Gly Thr Glu Glu Leu
         255                 260                 265

 cgg caa cga gaa cac tat ctc aag cag aag aga gat aag ttg atg tcc     1044
 Arg Gln Arg Glu His Tyr Leu Lys Gln Lys Arg Asp Lys Leu Met Ser
     270                 275                 280

 atg aga aag gat atg agg act aaa cag ata caa aat atg gag cag aaa     1092
 Met Arg Lys Asp Met Arg Thr Lys Gln Ile Gln Asn Met Glu Gln Lys
 285                 290                 295                 300

 gga aaa ccc act ggg gag gta gag gaa atg aca gag aaa cca gaa atg     1140
 Gly Lys Pro Thr Gly Glu Val Glu Glu Met Thr Glu Lys Pro Glu Met
                 305                 310                 315

 aca gca gag gag aag caa aca tta cta aag agg aga ttg ctt gca gag     1188
 Thr Ala Glu Glu Lys Gln Thr Leu Leu Lys Arg Arg Leu Leu Ala Glu
             320                 325                 330

 aaa ctc aaa gaa gaa gtt att aat aag taa t aattaagaac aatttaacaa     1239
 Lys Leu Lys Glu Glu Val Ile Asn Lys 
         335                 340

 aatggaagtt caaattgtct taaaaataaa ttatttagtc cttacactga aaaaaaaaaa   1299

 a                                                                   1300




      <210> 64
      <211> 693
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(638)

      <400> 64
 tactactact aaattcgcgg cccgtcgacc tgaccagcac c    atg gcg gtt ggc      53
                                                  Met Ala Val Gly
                                                    1

 aag aac aag cgc ctt acg aaa ggc ggc aaa aag gga gcc aag aag aaa      101
 Lys Asn Lys Arg Leu Thr Lys Gly Gly Lys Lys Gly Ala Lys Lys Lys
   5                  10                  15                  20

 gtg gtt gat cca ttt tct aag aaa gat tgg tat gat gtg aaa gca cct      149
 Val Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Val Lys Ala Pro
                  25                  30                  35

 gct atg ttc aat ata aga aat att gga aag acg ctc gtc acc agg acc      197
 Ala Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Leu Val Thr Arg Thr
              40                  45                  50

 caa gga acc aaa att gca tct gat ggt ctc aag ggt cgt gtg ttt gaa      245
 Gln Gly Thr Lys Ile Ala Ser Asp Gly Leu Lys Gly Arg Val Phe Glu
          55                  60                  65

 gtg agt ctt gct gat ttg cag aat gat gaa gtt gca ttt aga aaa ttc      293
 Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Val Ala Phe Arg Lys Phe
      70                  75                  80

 aag ctg att act gaa gat gtt cag ggt aaa aac tgc ctg act aac ttc      341
 Lys Leu Ile Thr Glu Asp Val Gln Gly Lys Asn Cys Leu Thr Asn Phe
  85                  90                  95                 100

 cat ggc atg gat ctt acc cgt gac aaa atg tgt tcc atg gtc aaa aaa      389
 His Gly Met Asp Leu Thr Arg Asp Lys Met Cys Ser Met Val Lys Lys
                 105                 110                 115

 tgg cag aca atg att gaa gct cac gtt gat gtc aag act acc gat ggt      437
 Trp Gln Thr Met Ile Glu Ala His Val Asp Val Lys Thr Thr Asp Gly
             120                 125                 130

 tac ttg ctt cgt ctg ttc tgt gtt ggt ttt act aaa aaa cgc aac aat      485
 Tyr Leu Leu Arg Leu Phe Cys Val Gly Phe Thr Lys Lys Arg Asn Asn
         135                 140                 145

 cag ata cgg aag acc tct tat gct cag cac caa cag gtc cgc caa atc      533
 Gln Ile Arg Lys Thr Ser Tyr Ala Gln His Gln Gln Val Arg Gln Ile
     150                 155                 160

 cgg aag aag atg atg gaa atc atg acc cga gag gtg cag act aat gac      581
 Arg Lys Lys Met Met Glu Ile Met Thr Arg Glu Val Gln Thr Asn Asp
 165                 170                 175                 180

 ttg aaa gaa gtg gtc aat aaa ttg att cca gac agc gtt gga aaa gac      629
 Leu Lys Glu Val Val Asn Lys Leu Ile Pro Asp Ser Val Gly Lys Asp
                 185                 190                 195

 ata gaa tag gcttgcc aatctattta tcctctccat gatgtcttcg ttagaaaagt      685
 Ile Glu 


 attacatg                                                             693




      <210> 65
      <211> 1310
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (293)..(769)

      <400> 65
 tttcgtgcgg ccggatcgca tctcagctgg ttggctttgg ttagagctcc cgtcagactt     60

 tcgttcggcc ctaggatttg gtagccccga agtgtgggct ctctccagta ccagactcat    120

 ttcagtacca gcctttggga agtcgtgtga atacctcggt ctcttagcca cagggataga    180

 atggcggcct gacggagccg cggcgccggc gaagtcgctg aggcgcgagc tggaaccccc    240

 agaccagctc aaacgggagc caaaactcga agcttggaag aattagcagg aa    atg     295
                                                              Met
                                                                1

 gcg gat gag gcg ttg ttt ttg ctt ctc cat aac gag atg gtg tct gga      343
 Ala Asp Glu Ala Leu Phe Leu Leu Leu His Asn Glu Met Val Ser Gly
               5                  10                  15

 gtg tac aag tcc gcg gag cag ggg gag gtg gaa aac gga cga tgt att      391
 Val Tyr Lys Ser Ala Glu Gln Gly Glu Val Glu Asn Gly Arg Cys Ile
          20                  25                  30

 act aag ctg gaa aac atg ggg ttt cga gtg gga caa gga ttg ata gaa      439
 Thr Lys Leu Glu Asn Met Gly Phe Arg Val Gly Gln Gly Leu Ile Glu
      35                  40                  45

 agg ttt aca aaa gat act gca agg ttc aag gat gag tta gat atc atg      487
 Arg Phe Thr Lys Asp Thr Ala Arg Phe Lys Asp Glu Leu Asp Ile Met
  50                  55                  60                  65

 aag ttc att tgt aaa gat ttt tgg act acg gta ttc aag aaa caa atc      535
 Lys Phe Ile Cys Lys Asp Phe Trp Thr Thr Val Phe Lys Lys Gln Ile
                  70                  75                  80

 gac aat cta agg aca aat cat cag ggc atc tat gta ctt cag gac aac      583
 Asp Asn Leu Arg Thr Asn His Gln Gly Ile Tyr Val Leu Gln Asp Asn
              85                  90                  95

 aaa ttt cgc ctg ctt act cag atg tct gca gga aaa cag tat tta gaa      631
 Lys Phe Arg Leu Leu Thr Gln Met Ser Ala Gly Lys Gln Tyr Leu Glu
         100                 105                 110

 cat gca tct aag tat tta gca ttt acg tgt ggc tta atc aga ggt ggc      679
 His Ala Ser Lys Tyr Leu Ala Phe Thr Cys Gly Leu Ile Arg Gly Gly
     115                 120                 125

 tta tca aac ttg gga ata aaa agt att gta aca gct gaa gtg tct tca      727
 Leu Ser Asn Leu Gly Ile Lys Ser Ile Val Thr Ala Glu Val Ser Ser
 130                 135                 140                 145

 atg cct gct tgc aaa ttt cag gtg atg ata cag aag ctg tag aacatac      776
 Met Pro Ala Cys Lys Phe Gln Val Met Ile Gln Lys Leu 
                 150                 155

 tgaaatgcaa ggcttcaaca gtgtaaagag ataaattatt catgtaaaag tatttcaagt    836

 agtgatgatt taattacatt gttcgatgtt tgtacaggag taagcatgta tttttatcaa    896

 tttaacacag atcaaaggag atgaagggac attctgccat gacatacact taaccaaaac    956

 tattcaaaat gaaaaccgga tttcaaataa ccagacacca agatgcaggg cccttatttt   1016

 aaaccttttt atttggttag agtgatatgt atttagccat agatggagaa acaaagctca   1076

 gggtttgttg aattagcatg agagaaaatt atgtaccaac agaattattt gtgagaagaa   1136

 tgaacaaatt ttgataaagt atgaatttgt tttattttaa aaagcaaaca tactaaattt   1196

 tttttatttt attgcttata atttattaag aatgtttaca cctgtataag gatttcatat   1256

 atacattgta tgtgtgtata tataaataca tatatgactg ccaaaaaaaa aaaa         1310




      <210> 66
      <211> 1409
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (432)..(1139)

      <400> 66
 gaggacgaag aagaggagtc ggagctggtg tccaagccgc tgctgcgcct cagcagccgc     60

 cggagctcca ttcgggggcc cgaaggcacc gagcagaacc gcgtgcgcaa caaactaaag    120

 cggctcatcg cgaagagacc gcccttacaa agcctgcagg agcggggtct gctccgaggt    180

 gagggggctg ggccaggttc atggataaga aaactccagc gaggctcaga gtagagcttc    240

 ccagaactag accacaacct tctgtgactg ctgctttccc actaccccag attgtttagg    300

 ggagaagctg gggtgacctg tacccctttg ccagattgtt tgaagcaggg gaagggaggt    360

 ggagtgtatt tccttgccca ggcctggcac aggcagccag gaggaccagc ctcacttaag    420

 gataaagacc t atg ctg aga aga gct cct gtg agt gac gct ggc act ggc     470
              Met Leu Arg Arg Ala Pro Val Ser Asp Ala Gly Thr Gly
                1               5                  10

 ttc ccg cct cac tct act tcc cca gac cag gtg ttc ggc tgc cag ttg      518
 Phe Pro Pro His Ser Thr Ser Pro Asp Gln Val Phe Gly Cys Gln Leu
      15                  20                  25

 gaa tca ctc tgc cag cgg gaa gga gac acg gtg ccc agc ttt ttg cgg      566
 Glu Ser Leu Cys Gln Arg Glu Gly Asp Thr Val Pro Ser Phe Leu Arg
  30                  35                  40                  45

 ctc tgc att gct gct gtg gat aaa aga ggt cta gat gtg gat ggc att      614
 Leu Cys Ile Ala Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile
                  50                  55                  60

 tat cgg gtg agc ggg aac ttg gca gtg gtc cag aag ctt cgc ttt ctg      662
 Tyr Arg Val Ser Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu
              65                  70                  75

 gtg gac aga gag cgt gcg gtc acc tcc gat ggg agg tat gtg ttc cca      710
 Val Asp Arg Glu Arg Ala Val Thr Ser Asp Gly Arg Tyr Val Phe Pro
          80                  85                  90

 gaa cag cca gga caa gaa ggt cgg tta gat ttg gac agt act gag tgg      758
 Glu Gln Pro Gly Gln Glu Gly Arg Leu Asp Leu Asp Ser Thr Glu Trp
      95                 100                 105

 gat gac att cat gtg gtc acc gga gcc ctg aag ctt ttt ctc cgg gag      806
 Asp Asp Ile His Val Val Thr Gly Ala Leu Lys Leu Phe Leu Arg Glu
 110                 115                 120                 125

 ctg ccc cag cct ctg gtg cca cca ctg ctg ctg ccc cat ttc cgt gct      854
 Leu Pro Gln Pro Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala
                 130                 135                 140

 gcc ctt gca ctc tcc gaa tca gag cag tgc ctc tct cag ata caa gaa      902
 Ala Leu Ala Leu Ser Glu Ser Glu Gln Cys Leu Ser Gln Ile Gln Glu
             145                 150                 155

 tta ata ggc tca atg cca aag ccc aac cat gac act cta cgg tac ctc      950
 Leu Ile Gly Ser Met Pro Lys Pro Asn His Asp Thr Leu Arg Tyr Leu
         160                 165                 170

 ctg gag cat tta tgc agg gtg ata gca cac tca gat aag aat cgc atg      998
 Leu Glu His Leu Cys Arg Val Ile Ala His Ser Asp Lys Asn Arg Met
     175                 180                 185

 aca ccc cac aac ctg gga att gtg ttt gga cca acc ctg ttt cgg cca     1046
 Thr Pro His Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Phe Arg Pro
 190                 195                 200                 205

 gag cag gag aca tct gac cca gca gcc cat gct ctc tac cca ggg cag     1094
 Glu Gln Glu Thr Ser Asp Pro Ala Ala His Ala Leu Tyr Pro Gly Gln
                 210                 215                 220

 ctg gtc cag ctg atg ctc acc aac ttc acc agc ctc ttc ccc tga tgc     1142
 Leu Val Gln Leu Met Leu Thr Asn Phe Thr Ser Leu Phe Pro 
             225                 230                 235

 agggaaggaa gaagagaaaa catatttccg gtcatctctg gtggtgagag gctggtgttc   1202

 tgttttgagg atatcccttt aaatctccca aatgactgtc tctatcttca tgagtgtgac   1262

 ttgaggtgtt gggatgggtg agggagcttc tctaaagagg aaagtgagtg gattaacccc   1322

 tgcttctctt cttgttccct gttatcattc ctccccaaca taataataca taaagtggca   1382

 tggtattttt tctgaaaaaa aaaaaaa                                       1409




      <210> 67
      <211> 5984
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2437)..(5139)

      <400> 67
 atggggagag accagcgcgc ggtggccggc cctgccctac ggcggtggct gctgctgggg     60

 acagtgaccg tggggttcct cgcccagagc gtcttggcgg gtgtgaagaa gtttgatgtg    120

 ccgtgtggag gaagagattg cagtgggggc tgccagtgct accctgagaa aggtggacgt    180

 ggtcagcctg ggccagtggg cccccagggg tacaatgggc caccaggatt acaaggattc    240

 cccgggctgc agggacgtaa aggagacaag ggtgaaaggg gagcccccgg agtaacagga    300

 cccaagggcg acgtgggagc aagaggcgtt tctggattcc ctggtgccga tggaattcct    360

 ggacacccgg ggcaaggtgg gcccagggga aggccgggct acgatggctg caacggaacc    420

 cagggagact caggtccaca ggggcccccc ggctctgagg ggttcaccgg gcctcccggg    480

 ccccaaggac caaaagggca gaaaggtgag ccttatgcac tgcctaaaga ggagcgcgac    540

 agatatcggg gtgaacctgg agagcctgga ttggtcggtt tccagggacc tcccggccgc    600

 cctgggcatg tgggacagat gggtccagtt ggagctccag ggagaccagg accacctgga    660

 ccccctggac caaaaggaca gcaaggcaac agaggacttg gtttctacgg agttaagggt    720

 gaaaagggtg acgtagggca gccgggaccc aacgggattc catcagacac cctccacccc    780

 atcatcgcgc ccacaggagt caccttccac ccagatcagt acaagggtga aaaaggcagt    840

 gagggggaac caggaataag aggcatttcc ttgaagggag aagaaggaat catgggcttt    900

 cctggactta ggggttaccc tggcttgagt ggtgaaaaag gatcaccagg acagaaggga    960

 agccgaggcc tggatggcta tcaagggcct gatggacccc ggggacctaa gggagaagcc   1020

 ggagacccag ggccccctgg actacctgcc tactcccctc acccttccct agcaaaaggt   1080

 gccagaggtg acccaggatt cccaggggcc caaggggagc caggaagcca gggtgagcca   1140

 ggagacccgg gcctcccagg tccccctggc ctctccattg gagatggaga tcagaggaga   1200

 ggcctgccgg gtgagatggg acccaagggc ttcatcggag accccggcat ccctgcgctc   1260

 tacgggggcc cacctggacc tgatggaaag cgagggcctc caggaccccc cgggctccct   1320

 ggaccacctg gacctgatgg cttcctgttt gggctgaaag gagcaaaagg aagagcaggc   1380

 ttccctgggc ttcccggctc ccctggagcc cccggaccaa aggggtggaa aggtgacgct   1440

 ggggaatgca gatgtacaga aggcgacgaa gctatcaaag gtcttccagg actgccagga   1500

 cccaagggct tcgcaggcat caacggggag ccggggagga aaggggacaa aggagacccc   1560

 ggccaacacg gcctccctgg gttcccaggg ctcaagggag tgcctggcaa cattggtgct   1620

 cccggaccca aaggagcaaa aggagattcc agaacaatca caaccaaagg tgagcgggga   1680

 cagcccggcg tcccaggtgt gcccgggatg aaaggtgacg atggcagccc aggccgcgat   1740

 gggctcgatg gattccccgg cctcccaggc cctcccggtg atggcatcaa gggccctcca   1800

 ggggacccag gttatccagg aatacctgga acgaagggta ctccaggaga aatgggcccc   1860

 ccaggactgg gccttcccgg cctcaaaggc caacgtggtt tccctggaga cgccggctta   1920

 cctggaccac caggcttcct gggccctcct ggccccgcag ggaccccagg acaaatagat   1980

 tgtgacacag atgtgaaaag ggccgttgga ggtgacagac aggaggccat ccagccaggt   2040

 tgcataggag ggcccaaggg attgccaggc ctgccaggac ccccaggccc cacaggtgcc   2100

 aaaggcctcc gaggaatccc aggcttcgca ggagctgatg gaggaccagg gcccaggggc   2160

 ttgccaggag acgcaggtcg tgaagggttc ccaggacccc cagggttcat aggaccccga   2220

 ggatccaaag gtgcagtggg cctccctggc ccagatggat ccccaggtcc catcggcctg   2280

 ccagggccag atgggccccc tggggaaagg ggcctccctg gagaagtcct gggagctcag   2340

 cccgggccac ggggagatgc tggtgtgcct ggacagcctg ggcttaaagg ccttcccgga   2400

 gacagaggcc cccctggatt cagaggaagc caaggg  atg cct ggg atg cca ggg    2454
                                          Met Pro Gly Met Pro Gly
                                            1               5

 ctg aag ggc cag cca ggc ctc cca gga cct tcc ggc cag cca ggc ctg     2502
 Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro Gly Leu
              10                  15                  20

 tat ggg cct cca gga ctg cat gga ttc cca gga gct cct ggc caa gag     2550
 Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly Gln Glu
          25                  30                  35

 ggg ccc ttg ggg ctg cca gga atc cca ggc cgt gaa ggt ctg cct ggt     2598
 Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu Pro Gly
      40                  45                  50

 gat aga ggg gac cct ggg gac aca ggc gct cct ggc cct gtg ggc atg     2646
 Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val Gly Met
  55                  60                  65                  70

 aaa ggt ctc tct ggt gac aga gga gat gct ggc ttc aca ggg gag caa     2694
 Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly Glu Gln
                  75                  80                  85

 ggc cat cca gga agc cct gga ttt aaa gga att gat gga atg cct ggg     2742
 Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met Pro Gly
              90                  95                 100

 acc ccc ggg cta aaa gga gat aga ggc tca cct ggg atg gat ggt ttc     2790
 Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp Gly Phe
         105                 110                 115

 caa ggc atg cct gga ctc aaa ggg aga ccc ggg ttt cca ggg agc aaa     2838
 Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly Ser Lys
     120                 125                 130

 ggc gag gct gga ttt ttc gga ata ccc ggt ctg aag ggt ctg gct ggt     2886
 Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu Ala Gly
 135                 140                 145                 150

 gag cca ggt ttt aaa ggc agc cga ggg gac cct ggg ccc cca gga cca     2934
 Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro Gly Pro
                 155                 160                 165

 cct cct gtc atc ctg cca gga atg aaa gac att aaa gga gag aaa gga     2982
 Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu Lys Gly
             170                 175                 180

 gat gaa ggg cct atg ggg ctg aaa gga tac ctg ggc gca aaa ggt atc     3030
 Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr Leu Gly Ala Lys Gly Ile
         185                 190                 195

 caa gga atg cca ggc atc cca ggg ctg tca gga atc cct ggg ctg cct     3078
 Gln Gly Met Pro Gly Ile Pro Gly Leu Ser Gly Ile Pro Gly Leu Pro
     200                 205                 210

 ggg agg ccc ggc cac atc aaa gga gtc aag gga gac atc gga gtc ccc     3126
 Gly Arg Pro Gly His Ile Lys Gly Val Lys Gly Asp Ile Gly Val Pro
 215                 220                 225                 230

 ggc atc ccc ggt ttg cca gga ttc cct ggg gtg gct ggc ccc cct gga     3174
 Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val Ala Gly Pro Pro Gly
                 235                 240                 245

 att acg gga ttc cca gga ttc ata gga agc cgg ggt gac aaa ggt gcc     3222
 Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser Arg Gly Asp Lys Gly Ala
             250                 255                 260

 cca ggg aga gca ggc ctg tat ggc gag att ggc gcg act ggt gat ttc     3270
 Pro Gly Arg Ala Gly Leu Tyr Gly Glu Ile Gly Ala Thr Gly Asp Phe
         265                 270                 275

 ggt gac atc ggg gac act ata aat tta cca gga aga cca ggc ctg aag     3318
 Gly Asp Ile Gly Asp Thr Ile Asn Leu Pro Gly Arg Pro Gly Leu Lys
     280                 285                 290

 ggg gag cgg ggc acc act gga ata cca ggt ctg aag gga ttc ttt gga     3366
 Gly Glu Arg Gly Thr Thr Gly Ile Pro Gly Leu Lys Gly Phe Phe Gly
 295                 300                 305                 310

 gag aag gga aca gaa ggt gac atc ggc ttc cct ggg ata aca ggc gtg     3414
 Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe Pro Gly Ile Thr Gly Val
                 315                 320                 325

 act gga gtc caa ggc cct cct gga ctt aaa gga caa aca ggc ttt cca     3462
 Thr Gly Val Gln Gly Pro Pro Gly Leu Lys Gly Gln Thr Gly Phe Pro
             330                 335                 340

 ggg ctg act ggg cct cca ggg tcg cag gga gag ctg ggg cgg att gga     3510
 Gly Leu Thr Gly Pro Pro Gly Ser Gln Gly Glu Leu Gly Arg Ile Gly
         345                 350                 355

 ctg cct ggt ggc aaa gga gat gat ggc tgg ccg gga gct ccg ggc tta     3558
 Leu Pro Gly Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala Pro Gly Leu
     360                 365                 370

 cca ggt ttt ccg gga ctc cgt ggg atc cgc ggc tta cac ggc ttg cca     3606
 Pro Gly Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly Leu Pro
 375                 380                 385                 390

 ggc acc aag ggc ttt cca gga tcc cca ggt tct gac atc cac gga gac     3654
 Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His Gly Asp
                 395                 400                 405

 cca ggc ttc cca ggc cct cct ggg gaa aga ggt gac cca gga gag gcc     3702
 Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly Glu Ala
             410                 415                 420

 aac acc ctt cca ggc cct gtg gga gtc cca gga cag aaa gga gac caa     3750
 Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys Gly Asp Gln
         425                 430                 435

 gga gct cca ggg gaa cga ggc cca cct ggg agc cca gga ctt cag ggg     3798
 Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly Leu Gln Gly
     440                 445                 450

 ttc cca ggc atc aca ccc cct tcc aac atc tct ggg gca cct ggt gac     3846
 Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly Ala Pro Gly Asp
 455                 460                 465                 470

 aaa ggg gcg cca ggg ata ttt ggc ctg aaa ggt tat cgg ggc cca cca     3894
 Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly Tyr Arg Gly Pro Pro
                 475                 480                 485

 ggg cca cca ggt tct gct gct ctt cct gga agc aaa ggt gac aca ggg     3942
 Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly Ser Lys Gly Asp Thr Gly
             490                 495                 500

 aac cca gga gct cca gga acc cca ggg acc aaa gga tgg gcc ggg gac     3990
 Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr Lys Gly Trp Ala Gly Asp
         505                 510                 515

 tcc ggg ccc cag ggc agg cct ggt gtg ttt ggt ctc cca gga gaa aaa     4038
 Ser Gly Pro Gln Gly Arg Pro Gly Val Phe Gly Leu Pro Gly Glu Lys
     520                 525                 530

 ggg ccc agg ggt gaa caa ggc ttc atg ggg aac act gga ccc acc ggg     4086
 Gly Pro Arg Gly Glu Gln Gly Phe Met Gly Asn Thr Gly Pro Thr Gly
 535                 540                 545                 550

 gcg gtg ggc gac aga ggc ccc aag gga ccc aag gga gac cca gga ttc     4134
 Ala Val Gly Asp Arg Gly Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe
                 555                 560                 565

 cct ggt gcc ccc ggg act gtg gga gcc ccc ggg att gca gga atc ccc     4182
 Pro Gly Ala Pro Gly Thr Val Gly Ala Pro Gly Ile Ala Gly Ile Pro
             570                 575                 580

 cag aag att gcc gtc caa cca ggg aca gtg ggt ccc cag ggg agg cga     4230
 Gln Lys Ile Ala Val Gln Pro Gly Thr Val Gly Pro Gln Gly Arg Arg
         585                 590                 595

 ggc ccc cct ggg gca ccg ggg gag atg ggg ccc cag ggc ccc ccc gga     4278
 Gly Pro Pro Gly Ala Pro Gly Glu Met Gly Pro Gln Gly Pro Pro Gly
     600                 605                 610

 gaa cca ggt ttt cgt ggg gct cca ggg aaa gct ggg ccc caa gga aga     4326
 Glu Pro Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln Gly Arg
 615                 620                 625                 630

 ggt ggt gtg tct gct gtt ccc ggc ttc cgg gga gat gaa gga ccc ata     4374
 Gly Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly Pro Ile
                 635                 640                 645

 ggc cac cag ggg ccg att ggc caa gaa ggt gca cca ggc cgt cca ggg     4422
 Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg Pro Gly
             650                 655                 660

 agc ccg ggc ctg ccg ggt atg cca ggc cgc agc gtc agc atc ggc tac     4470
 Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser Ile Gly Tyr
         665                 670                 675

 ctc ctg gtg aag cac agc cag acg gac cag gag ccc atg tgc cca gtg     4518
 Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met Cys Pro Val
     680                 685                 690

 ggc atg aac aaa ctc tgg agt gga tac agc ctg ctg tac ttc gag ggc     4566
 Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr Phe Glu Gly
 695                 700                 705                 710

 cag gag aag gcg cac aac cag gac ctg ggg ctg gcg ggc tcc tgc ctg     4614
 Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser Cys Leu
                 715                 720                 725

 gcg cgg ttc agc acc atg ccc ttc ctg tac tgc aac cct ggt gat gtc     4662
 Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro Gly Asp Val
             730                 735                 740

 tgc tac tat gcc agc cgg aac gac aag tcc tac tgg ctc tct acc act     4710
 Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu Ser Thr Thr
         745                 750                 755

 gcg ccg ctg ccc atg atg ccc gtg gcc gag gac gag atc aag ccc tac     4758
 Ala Pro Leu Pro Met Met Pro Val Ala Glu Asp Glu Ile Lys Pro Tyr
     760                 765                 770

 atc agc cgc tgt tct gtg tgt gag gcc ccg gcc atc gcc atc gcg gtc     4806
 Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ala Ile Ala Ile Ala Val
 775                 780                 785                 790

 cac agt cag gat gtc tcc atc cca cac tgc cca gct ggg tgg cgg agt     4854
 His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp Arg Ser
                 795                 800                 805

 ttg tgg atc gga tat tcc ttc ctc atg cac acg gcg gcg gga gac gaa     4902
 Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly Asp Glu
             810                 815                 820

 ggc ggt ggc caa tca ctg gtg tca ccg ggc agc tgt cta gag gac ttc     4950
 Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu Glu Asp Phe
         825                 830                 835

 cgc gcc aca cca ttc atc gaa tgc aat gga ggc cgc ggc acc tgc cac     4998
 Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr Cys His
     840                 845                 850

 tac tac gcc aac aag tac agc ttc tgg ctg acc acc att ccc gag cag     5046
 Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro Glu Gln
 855                 860                 865                 870

 agc ttc cag ggc tcg ccc tcc gcc gac acg ctc aag gcc ggc ctc atc     5094
 Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly Leu Ile
                 875                 880                 885

 cgc aca cac atc agc cgc tgc cag gtg tgc atg aag aac ctg tga gcc     5142
 Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu 
             890                 895                 900

 ggcgcgtgcc aggaagggcc attttggtgc ttattcttaa cttattacct caggtgccaa   5202

 cccaaaaatt ggttttattt ttttcttaaa aaaaaaaaag tctaccaaag gaatttgcat   5262

 ccagcagcag cacttagacc tgccagccac tgtcaccgag cgggtgcaag cactcggggt   5322

 ccctggaggg caagccctgc ccacagaaag ccaggagcag ccctggcccc catcagccct   5382

 gctagacgca ccgcctgaag gcacagctaa ccacttcgca cacacccatg taaccactgc   5442

 actttccaat gccacagaca actcacattg ttcaactccc ttctcggggt gggacagacg   5502

 agacaacagc acacaggcag ccagccgtgg ccagaggctc gaggggctca ggggctcagg   5562

 cacccgtccc cacacgaggg ccccgtgggt gggcctggcc ctgctttcta cgccaatgtt   5622

 atgccagctc catgttctcc caaataccgt tgatgtgaat tattttaaag gcaaaactgt   5682

 gctctttatt ttaaaaaaca ctgataatca cactgcggta ggtcattctt ttgccacatc   5742

 cctatagacc actgggtttg gcaaaactca ggcagaagtg gagacctttc tagacatcat   5802

 tgtcagcctt gctacttgaa ggtacacccc atagggtcgg aggtgctgtc cccactgccc   5862

 caccttgtcc ctgagattta acccctccac tgctgggggt gagctgtact cttctgactg   5922

 ccccctcctg tgtaacgact acaaaataaa acttggttct gaatattttt aaaaaaaaaa   5982

 aa                                                                  5984




      <210> 68
      <211> 1827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(968)

      <400> 68
 cggccgccgc gctcccagca tggctgtctc tgcagtcgag ggcaaggact ctgcgtgcat     60

 tctccactgc cgtctactcg gccactccgg tcccgacacc tagcctgccg gaaagaacac    120

 ccggaaatga aaggccacca agaagaaagg cactacctcc taggacagag aaa   atg     176
                                                              Met
                                                                1

 gct gtt gac cag gac tgg cct agt gtt tac cca gtt gca gca cca ttt      224
 Ala Val Asp Gln Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe
               5                  10                  15

 aaa ccc tct gca gta cct ctt cct gtt cga atg ggt tat cca gta aaa      272
 Lys Pro Ser Ala Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys
          20                  25                  30

 aag ggc gtg ccc atg gca aag gag gga aat cta gaa ctt tta aag att      320
 Lys Gly Val Pro Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile
      35                  40                  45

 ccc aat ttt ctg cat ttg act cct gta gca att aaa aag cac tgt gaa      368
 Pro Asn Phe Leu His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu
  50                  55                  60                  65

 gcc ctt aaa gat ttt tgc act gag tgg cca gcc gca ctg gac agt gac      416
 Ala Leu Lys Asp Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp
                  70                  75                  80

 gag aaa tgt gag aag cat ttt cca att gaa att gac agc act gat tat      464
 Glu Lys Cys Glu Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr
              85                  90                  95

 gtt tca tca gga cca tct gtt cgg aac ccc aga gca cga gta gta gtc      512
 Val Ser Ser Gly Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val
         100                 105                 110

 tta aga gta aag ctt tcc agt ttg aat tta gat gat cac gca aag aag      560
 Leu Arg Val Lys Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys
     115                 120                 125

 aaa tta att aaa ctt gta gga gag cga tac tgc aag acc aca gat gtg      608
 Lys Leu Ile Lys Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val
 130                 135                 140                 145

 ctt acc atc aaa aca gat agg tgc cct tta agg agg cag aat tac gat      656
 Leu Thr Ile Lys Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp
                 150                 155                 160

 tat gca gtg tat cta cta aca gtg tta tac cat gag tct tgg aat act      704
 Tyr Ala Val Tyr Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr
             165                 170                 175

 gaa gaa tgg gaa aaa agt aag act gaa gca gac atg gaa gag tat ata      752
 Glu Glu Trp Glu Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile
         180                 185                 190

 tgg gaa aat agc tca tca gaa aga aat atc ctg gaa acg ctt ctc cag      800
 Trp Glu Asn Ser Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln
     195                 200                 205

 atg aaa gct gct gag aaa aat atg gaa ata aat aaa gaa gag ctc ctt      848
 Met Lys Ala Ala Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu
 210                 215                 220                 225

 ggt act aaa gaa att gaa gag tac aaa aag tct gtt gtt agt ctt aaa      896
 Gly Thr Lys Glu Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys
                 230                 235                 240

 aat gag gag gaa aat gaa aat tcc att tct cag tac aaa gaa tcc gtg      944
 Asn Glu Glu Glu Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val
             245                 250                 255

 aag aga cta tta aat gtg aca tga attatggagt agaaaaatct gcttgattta     998
 Lys Arg Leu Leu Asn Val Thr 
         260

 ttaattttat gatatatgtg atcagtatct aatttgatat aaaattgaaa atgttaaaaa   1058

 atcatttttt ttcctcagag ttaaaattat ttccctcata ctaatgctta atggcaatga   1118

 ttactccaga gttttttaat ttttacactg gggcaataga ctaggaggtc tctgatttct   1178

 tcttggtcta aagtgttttg attttatttc tacataatag ctttggtatt catgtatata   1238

 catgcattta attgtgattt tatcaccttt cccatttctt tccccacaag ctggcatttc   1298

 agtagttgct tttgaataat ggttttggtt acctgggaag gcaggcccag aacccatttc   1358

 cttgacttgc agttccgggc tgtgttcaca tgactgctgt ctagctgatg catttttcac   1418

 atttgtcaac tctggttaga aacaggtcct caggagtatt ctctaacctg atattttcta   1478

 aaaagatatg ttgattcaac tttgtttagc atcctacttt ctagattgtg gggctcattt   1538

 tgccagggcc aagctaccag aaaagtagaa gtggagatta cctggtatgt atctctctgg   1598

 gtgccccagt tagagctgcc acagctcagg aaaaagatga ggcataacga ccttgaatgt   1658

 aattggagta agtgacaaaa taagaactac cctgggaaac cctgcattca atgtagctgt   1718

 caattcagta tttttaagta cacctgtcag ctgtttctta ccacttcgat ggttgtgatt   1778

 aatttaaaat caaaataaag gaattactga gtttaaaaaa aaaaaaaaa               1827




      <210> 69
      <211> 727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(440)

      <400> 69
 tgaggcggcc gaccttcggc ccgaggcacc ggggcgccgg gacggcgaag   atg tcg      56
                                                          Met Ser
                                                            1

 gct tcc tta gtc cgg gca act gtc cgg gct gtg agc aag agg aag ctg      104
 Ala Ser Leu Val Arg Ala Thr Val Arg Ala Val Ser Lys Arg Lys Leu
           5                  10                  15

 cag ccc acc cgg gca gcc ctc acc ctg aca cct tca gca gta aac aag      152
 Gln Pro Thr Arg Ala Ala Leu Thr Leu Thr Pro Ser Ala Val Asn Lys
      20                  25                  30

 ata aaa caa ctt ctt aaa gat aag cct gag cat gta ggt gta aaa gtt      200
 Ile Lys Gln Leu Leu Lys Asp Lys Pro Glu His Val Gly Val Lys Val
  35                  40                  45                  50

 ggt gtc cga acc agg ggc tgt aat ggc ctt tct tat act cta gaa tat      248
 Gly Val Arg Thr Arg Gly Cys Asn Gly Leu Ser Tyr Thr Leu Glu Tyr
                  55                  60                  65

 aca aag aca aaa gga gat tct gat gaa gaa gtt att caa gat gga gtc      296
 Thr Lys Thr Lys Gly Asp Ser Asp Glu Glu Val Ile Gln Asp Gly Val
              70                  75                  80

 aga gta ttc atc gaa aag aaa gca cag cta aca ctt tta gga aca gaa      344
 Arg Val Phe Ile Glu Lys Lys Ala Gln Leu Thr Leu Leu Gly Thr Glu
          85                  90                  95

 atg gac tat gtt gaa gac aaa tta tcc agt gag ttt gtg ttc aat aac      392
 Met Asp Tyr Val Glu Asp Lys Leu Ser Ser Glu Phe Val Phe Asn Asn
     100                 105                 110

 cca aac atc aaa ggg act tgt ggc tgt gga gaa agc ttt aat att tga      440
 Pro Asn Ile Lys Gly Thr Cys Gly Cys Gly Glu Ser Phe Asn Ile 
 115                 120                 125

 aatctcagga ctcttctggc cgtaggttcc aggaaagctc gtggaagctt tggggctcac    500

 tgcagaaatc atgtgactgt cacgtgctgg aaaataaagt gatacatctt gaaaatgaat    560

 ccagtgtgtt ggattccaga agaaatgata tttatattct ctatagggga cagaaaatga    620

 gaagccatca ctctttttgg atcatttagg tctcttgtat cctttgtttt agaaccagtt    680

 tcattaaagt tgccttcctg ggcacctgtt tatccaaaaa aaaaaaa                  727




      <210> 70
      <211> 2211
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(474)

      <400> 70
 gacccgacct ctggctaacc tacccccgga gcc atg gcc tct gct ggg gtg gca      54
                                      Met Ala Ser Ala Gly Val Ala
                                        1               5

 gcc ggg cga cag gcg gag gat gta ttg ccg cca acg tcc gac cag ccg      102
 Ala Gly Arg Gln Ala Glu Asp Val Leu Pro Pro Thr Ser Asp Gln Pro
          10                  15                  20

 ctg cct gac acc aag ccg ctg ccg cct cct cag ccg ccg ccg gtc cct      150
 Leu Pro Asp Thr Lys Pro Leu Pro Pro Pro Gln Pro Pro Pro Val Pro
      25                  30                  35

 gcg cct caa ccg cag cag tcg ccg gcg cca cgg cct cag tca cct gcc      198
 Ala Pro Gln Pro Gln Gln Ser Pro Ala Pro Arg Pro Gln Ser Pro Ala
  40                  45                  50                  55

 cgc gcg agg gag gaa gag aac tac tcc ttt tta cct ttg gtt cac aac      246
 Arg Ala Arg Glu Glu Glu Asn Tyr Ser Phe Leu Pro Leu Val His Asn
                  60                  65                  70

 atc atc aaa tgc atg gac aag gac agc ccg gag gtc cac cag gac ctg      294
 Ile Ile Lys Cys Met Asp Lys Asp Ser Pro Glu Val His Gln Asp Leu
              75                  80                  85

 aac gcc ctc aaa agc aag ttc cag gag atg cgc aag ctc atc agc acc      342
 Asn Ala Leu Lys Ser Lys Phe Gln Glu Met Arg Lys Leu Ile Ser Thr
          90                  95                 100

 atg ccc ggc atc cac ctg agc ccc gaa cag cag cag cag cag ctg cag      390
 Met Pro Gly Ile His Leu Ser Pro Glu Gln Gln Gln Gln Gln Leu Gln
     105                 110                 115

 agc ctc cgg gag caa gtc agg acc aag aat gag ctt ctg caa aag tac      438
 Ser Leu Arg Glu Gln Val Arg Thr Lys Asn Glu Leu Leu Gln Lys Tyr
 120                 125                 130                 135

 aag agc ctc tgc atg ttc gaa atc ccc aag gag tag agtg aggctgactt      488
 Lys Ser Leu Cys Met Phe Glu Ile Pro Lys Glu 
                 140                 145

 ccttagaaag agggggaagc caatggcctg tctccccact accatcccca aacgctcctt    548

 ggggcgtggt tcctgtggac cccagctcag ctcgtcaagc tgcaggggcg gggctcctgt    608

 gctgctgcgc gcgcttcgcc tgtgcgggag ccagcgcaga gcttggctgc gccgggggtt    668

 cctcgtgtag atccatatgt ctagatgcat aataactgga gtgcctgctg gtggaagtca    728

 gaatgctcct ggaggctgca gagggggtgg aggactctcc cctgcctctg gggagggggc    788

 catctgctgc gcccggcccc actgacagat ctgaagagca cagtaggaag ggaggcggct    848

 cctctttgct tccttccctc tctctcctcc cacccccata ggatcagtgt gtaccaggta    908

 cacattgttc ctgttaacag cagcttcttg aaacatttgc atagaattca ctggacgaat    968

 taagcctgca ctcatatggc atagaattgt gagagaatgt tttgaaaggc cagagggtgg   1028

 cctttttccc caaacagttt ggttcctttt atgtttgagc cagtgaaggg aactacgctt   1088

 tgggggcttc agcctagagc cctgccaggc agcccctggc tccaggttcc ctgcctccta   1148

 gcgctctcct cgccttcagc tcttgctccc ttcctcgttc atcaccctca gtcagtgccc   1208

 aagagtggcc aaaccgcttc acatctgcag tgcttcccca gggttgacaa ggggccgtcc   1268

 tttccacaca ggccagaaga ggtcttcagg cgaaccgacc ttcccccttc tggcatttca   1328

 gattcccctg cctctggtta aaaggtcttt ccctcgtggc ctttgcactt gcggcagcaa   1388

 cgtgtactac actgcagaag ggttcagtat gcaccttgtg ttgagagaga ggcaaccctg   1448

 ggggccagtt caggtggtcc ccaaccataa gctaggtctg aaagttacac agccaagttt   1508

 gagctcttaa aagttgatga acagcctcat ttccccagct tccctgattt cttccagatg   1568

 ggacgtttta tttgtgtgct ctcccttgac tgtcagattg aagtaagagc agttctctcc   1628

 gttgcctctc gaggaggagg tgcgaagtcc tggagtattg tttgggtctc ggaatgggcg   1688

 cataacctgc gctgaccagt ttaggggctt agcagatgcc tgccagctga cctcgttggc   1748

 aggagggttg ggtggagatg tttttagcag agcttccatt agtgtagacc tgtagccacc   1808

 tgtcagaagg tgggtggcat attggggacc tgggaatgtg tgaaggagga gatcaaattt   1868

 cagtggcttt ggacagaaaa gaaggctctg gatttaagcg ggtggtcacc tgtgagacca   1928

 ggtctacctt gggactgtta tttaactgaa tcagttattt ccttgaaatt tcacagtagt   1988

 gggtgggcct gttttaaggc tctgacagat accacgaaac atgaagcacg tggaactaca   2048

 agacccccgg ggtctttctg agtgcaaggc tgaaatggac aagggctcct cacgggggtg   2108

 gagggagccg gagcctgcct tgtgttcctt ttttgacttg tgacattttt caaacacata   2168

 attaaaagga cttatgctct gctgtctcag gaaaaaaaaa aaa                     2211




      <210> 71
      <211> 1672
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (522)..(1187)

      <400> 71
 ggttctcagc caccaaagct gcagggtctc gtcgttcgtt ccctctggcc tggcggaact     60

 tgcgtgggaa gctgggagga cagaaggctt agccgctggg tccctgagct ggctggagcg    120

 cgggctgtct aggggcggcg acctcagctg ttgggctccg gctgctgggg gctgtgcgtc    180

 cagccgccct ggaatccgcc tgtgggtggg ccgcttggct ctcccacttc accctcttga    240

 taacccagag cctccccctt cccacgtacg taggggaagg ataatctact tccttttgaa    300

 cagcttcggt ccccactatg acagtcgcat aaacttcagc gaagagtgcg ctggtaccac    360

 tgatgaaatt atgaccaggt gggcccgagt tagtaccaca tataacaaga gacccttgcc    420

 tgcaacatca tgggaggaca tgaagaaggg atcctttgag ggaacaagcc aaaacctacc    480

 aaagcgtaaa caacttgaag ccaataggct atccctcaaa a    atg atg cac ccc     533
                                                  Met Met His Pro
                                                    1

 aag caa aac ata aaa aga aca aaa aga aaa aaa gag tac tta aat gaa      581
 Lys Gln Asn Ile Lys Arg Thr Lys Arg Lys Lys Glu Tyr Leu Asn Glu
   5                  10                  15                  20

 gat gtg aat gga ttc atg gaa tac cta aga cag aat tca cag atg gtt      629
 Asp Val Asn Gly Phe Met Glu Tyr Leu Arg Gln Asn Ser Gln Met Val
                  25                  30                  35

 cac aat ggg caa att ata gca aca gac agt gag gaa gta agg gaa gaa      677
 His Asn Gly Gln Ile Ile Ala Thr Asp Ser Glu Glu Val Arg Glu Glu
              40                  45                  50

 att gca gtt gct tta aag aaa gac agt cga cgg gaa gga aga aga tta      725
 Ile Ala Val Ala Leu Lys Lys Asp Ser Arg Arg Glu Gly Arg Arg Leu
          55                  60                  65

 aaa aga caa gcg gca aag aaa aat gca atg gtg tgt ttc cat tgt aga      773
 Lys Arg Gln Ala Ala Lys Lys Asn Ala Met Val Cys Phe His Cys Arg
      70                  75                  80

 aaa cct ggt cat gga att gca gat tgc ccc gcc gcc ctt gaa aat caa      821
 Lys Pro Gly His Gly Ile Ala Asp Cys Pro Ala Ala Leu Glu Asn Gln
  85                  90                  95                 100

 gac atg ggc act ggg ata tgt tac agg tgt ggg tcc aca gag cac gaa      869
 Asp Met Gly Thr Gly Ile Cys Tyr Arg Cys Gly Ser Thr Glu His Glu
                 105                 110                 115

 ata acc aag tgt aag gct aaa gta gac ccg gct ctt ggc gaa ttt cct      917
 Ile Thr Lys Cys Lys Ala Lys Val Asp Pro Ala Leu Gly Glu Phe Pro
             120                 125                 130

 ttt gca aaa tgt ttt gtt tgt gga gaa atg ggg cac ctg tct aga tct      965
 Phe Ala Lys Cys Phe Val Cys Gly Glu Met Gly His Leu Ser Arg Ser
         135                 140                 145

 tgt cct gat aat ccc aaa gga ctc tat gct gat ggt ggc ggt tgc aaa     1013
 Cys Pro Asp Asn Pro Lys Gly Leu Tyr Ala Asp Gly Gly Gly Cys Lys
     150                 155                 160

 ctt tgt ggc tct gtg gaa cat tta aag aaa gat tgc cct gaa agt cag     1061
 Leu Cys Gly Ser Val Glu His Leu Lys Lys Asp Cys Pro Glu Ser Gln
 165                 170                 175                 180

 aat tca gag cga atg gtc aca gtt ggt cgc tgg gca aag gga atg agt     1109
 Asn Ser Glu Arg Met Val Thr Val Gly Arg Trp Ala Lys Gly Met Ser
                 185                 190                 195

 gca gac tat gaa gaa att ttg gat gta cct aaa ccg caa aaa ccc aaa     1157
 Ala Asp Tyr Glu Glu Ile Leu Asp Val Pro Lys Pro Gln Lys Pro Lys
             200                 205                 210

 aca aaa ata cct aaa gtt gtt aat ttt tga t aacagctagc actatcatga     1208
 Thr Lys Ile Pro Lys Val Val Asn Phe 
         215                 220

 gttactacct cattgttact ttctaaacca ggcccgcttc acgagttaga gttgagctcc   1268

 cctgtagcca ggactatgct gtagatatca gtatgatctg ggtgtggcca aaaacaattt   1328

 tctttattct gtctatcaaa tagtacttct accactgttt ggagaaaatt gaagaaaaga   1388

 ataagatgat taaatgaatt ctctaaaaga acatatttta agagacagaa cttagacata   1448

 accaagtagt tgtatacctg attgtaacaa tcatctttta taaaagcaaa attatgcata   1508

 aatgtaaaac acccctaaac aaagggaaca aatgaatttt tggttatatt gttttcttgg   1568

 ctcaaagtat caatttatta ttataataga aatttataag ttgctagaaa gtctatattt   1628

 ttaaagtacg gaataaaaat atgttttcta ttaaaaaaaa aaaa                    1672




      <210> 72
      <211> 3725
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (224)..(1831)

      <400> 72
 agcaacactt ttcttgtttg taaacgcgag tgaccagaaa gtgtgaatgc ggagtaggaa     60

 tatttttcgt gttctctttt atctgcttgc cttttttaga gagtagcagt ggttcctatt    120

 tcggaaaagg acgttctaat tcaaagctct ctcccaatat atttacacga atacgcattt    180

 agaaagggag gcagcttttg aggttgcaat cctactgaga agg  atg gaa gaa gga     235
                                                  Met Glu Glu Gly
                                                    1

 gcc agg cac cga aac aac acc gaa aag aaa cac cca ggt ggg gga gag      283
 Ala Arg His Arg Asn Asn Thr Glu Lys Lys His Pro Gly Gly Gly Glu
   5                  10                  15                  20

 tcg gac gcc agc ccc gag gct ggt tcc gga ggg ggc gga gta gcc ctg      331
 Ser Asp Ala Ser Pro Glu Ala Gly Ser Gly Gly Gly Gly Val Ala Leu
                  25                  30                  35

 aag aaa gag atc gga ttg gtc agt gcc tgt ggt atc atc gta ggg aac      379
 Lys Lys Glu Ile Gly Leu Val Ser Ala Cys Gly Ile Ile Val Gly Asn
              40                  45                  50

 atc atc ggc tct gga atc ttt gtc tcg cca aag gga gtg ctg gag aat      427
 Ile Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Glu Asn
          55                  60                  65

 gct ggt tct gtg ggc ctt gct ctc atc gtc tgg att gtg acg ggc ttc      475
 Ala Gly Ser Val Gly Leu Ala Leu Ile Val Trp Ile Val Thr Gly Phe
      70                  75                  80

 atc aca gtt gtg gga gcc ctc tgc tat gct gaa ctc ggg gtc acc atc      523
 Ile Thr Val Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Val Thr Ile
  85                  90                  95                 100

 ccc aaa tct gga ggt gac tac tcc tat gtc aag gac atc ttc gga gga      571
 Pro Lys Ser Gly Gly Asp Tyr Ser Tyr Val Lys Asp Ile Phe Gly Gly
                 105                 110                 115

 ctg gct ggg ttc ctg agg ctg tgg att gct gtg ctg gtg atc tac ccc      619
 Leu Ala Gly Phe Leu Arg Leu Trp Ile Ala Val Leu Val Ile Tyr Pro
             120                 125                 130

 acc aac cag gct gtc atc gcc ctc acc ttc tcc aac tac gtg ctg cag      667
 Thr Asn Gln Ala Val Ile Ala Leu Thr Phe Ser Asn Tyr Val Leu Gln
         135                 140                 145

 ccg ctc ttc ccc acc tgc ttc ccc cca gag tct ggc ctt cgg ctc ctg      715
 Pro Leu Phe Pro Thr Cys Phe Pro Pro Glu Ser Gly Leu Arg Leu Leu
     150                 155                 160

 gct gcc atc tgc tta ttg ctc ctc aca tgg gtc aac tgt tcc agt gtg      763
 Ala Ala Ile Cys Leu Leu Leu Leu Thr Trp Val Asn Cys Ser Ser Val
 165                 170                 175                 180

 cgg tgg gcc acc cgg gtt caa gac atc ttc aca gct ggg aag ctc ctg      811
 Arg Trp Ala Thr Arg Val Gln Asp Ile Phe Thr Ala Gly Lys Leu Leu
                 185                 190                 195

 gcc ttg gcc ctg att atc atc atg ggg att gta cag ata tgc aaa gga      859
 Ala Leu Ala Leu Ile Ile Ile Met Gly Ile Val Gln Ile Cys Lys Gly
             200                 205                 210

 gag tac ttc tgg ctg gag cca aag aat gca ttt gag aat ttc cag gaa      907
 Glu Tyr Phe Trp Leu Glu Pro Lys Asn Ala Phe Glu Asn Phe Gln Glu
         215                 220                 225

 cct gac atc ggc ctc gtc gca ctg gct ttc ctt cag ggc tcc ttt gcc      955
 Pro Asp Ile Gly Leu Val Ala Leu Ala Phe Leu Gln Gly Ser Phe Ala
     230                 235                 240

 tat gga ggc tgg aac ttt ctg aat tac gtg act gag gag ctt gtt gat     1003
 Tyr Gly Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu Glu Leu Val Asp
 245                 250                 255                 260

 ccc tac aag aac ctt ccc aga gcc atc ttc atc tcc atc cca ctg gtc     1051
 Pro Tyr Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser Ile Pro Leu Val
                 265                 270                 275

 aca ttt gtg tat gtc ttt gcc aat gtc gct tat gtc act gca atg tcc     1099
 Thr Phe Val Tyr Val Phe Ala Asn Val Ala Tyr Val Thr Ala Met Ser
             280                 285                 290

 ccc cag gag ctg ctg gca tcc aac gcc gtc gct gtg act ttt gga gag     1147
 Pro Gln Glu Leu Leu Ala Ser Asn Ala Val Ala Val Thr Phe Gly Glu
         295                 300                 305

 aag ctc cta gga gtc atg gcc tgg atc atg ccc att tct gtt gcc ctg     1195
 Lys Leu Leu Gly Val Met Ala Trp Ile Met Pro Ile Ser Val Ala Leu
     310                 315                 320

 tcc aca ttt gga gga gtt aat ggg tct ctc ttc acc tcc tct cgg ctg     1243
 Ser Thr Phe Gly Gly Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu
 325                 330                 335                 340

 ttc ttc gct gga gcc cga gag ggc cac ctt ccc agt gtg ttg gcc atg     1291
 Phe Phe Ala Gly Ala Arg Glu Gly His Leu Pro Ser Val Leu Ala Met
                 345                 350                 355

 atc cac gtg aag cgc tgc acc cca atc cca gcc ctg ctc ttc aca tgc     1339
 Ile His Val Lys Arg Cys Thr Pro Ile Pro Ala Leu Leu Phe Thr Cys
             360                 365                 370

 atc tcc acc ctg ctg atg ctg gtc acc agc gac atg tac aca ctc atc     1387
 Ile Ser Thr Leu Leu Met Leu Val Thr Ser Asp Met Tyr Thr Leu Ile
         375                 380                 385

 aac tac gtg ggc ttc atc aac tac ctc ttc tat ggg gtc acg gtt gct     1435
 Asn Tyr Val Gly Phe Ile Asn Tyr Leu Phe Tyr Gly Val Thr Val Ala
     390                 395                 400

 gga cag ata gtc ctt cgc tgg aag aag cct gat atc ccc cgc ccc atc     1483
 Gly Gln Ile Val Leu Arg Trp Lys Lys Pro Asp Ile Pro Arg Pro Ile
 405                 410                 415                 420

 aag atc aac ctg ctg ttc ccc atc atc tac ttg ctg ttc tgg gcc ttc     1531
 Lys Ile Asn Leu Leu Phe Pro Ile Ile Tyr Leu Leu Phe Trp Ala Phe
                 425                 430                 435

 ctg ctg gtc ttc agc ctg tgg tca gag ccg gtg gtg tgt ggc att ggc     1579
 Leu Leu Val Phe Ser Leu Trp Ser Glu Pro Val Val Cys Gly Ile Gly
             440                 445                 450

 ctg gcc atc atg ctg aca gga gtg cct gtc tat ttc ctg ggt gtt tac     1627
 Leu Ala Ile Met Leu Thr Gly Val Pro Val Tyr Phe Leu Gly Val Tyr
         455                 460                 465

 tgg caa cac aag ccc aag tgt ttc agt gac ttc att gag ctg cta acc     1675
 Trp Gln His Lys Pro Lys Cys Phe Ser Asp Phe Ile Glu Leu Leu Thr
     470                 475                 480

 ctg gtg agc cag aag atg tgt gtg gtc gtg tac ccc gag gtg gag cgg     1723
 Leu Val Ser Gln Lys Met Cys Val Val Val Tyr Pro Glu Val Glu Arg
 485                 490                 495                 500

 ggc tca ggg aca gag gag gct aat gag gac atg gag gag cag cag cag     1771
 Gly Ser Gly Thr Glu Glu Ala Asn Glu Asp Met Glu Glu Gln Gln Gln
                 505                 510                 515

 ccc atg tac caa ccc act ccc acg aag gac aag gac gtg gcg ggg cag     1819
 Pro Met Tyr Gln Pro Thr Pro Thr Lys Asp Lys Asp Val Ala Gly Gln
             520                 525                 530

 ccc cag ccc tga gga ccaccattcc ctggctactc tctccttcct ccccctttta     1874
 Pro Gln Pro 
         535

 tcctacctcc ctgccttggt cccgccaaca catgcgagta cacacacacc cctctctctg   1934

 cttttgtcag gcagtggtag gactttggtg tgggtggtga gaaattgtaa acaaaaactg   1994

 acattcatac ccaaagaacc agcctctcac cccagggtcc atgtcccagg ccccactcca   2054

 gtgctgccca cactcccagc tgctggagga gaggggagat gccaaggtgc cctgcaggac   2114

 ctccctccgg gccacaccct cagctgcctc ttcaggaacc ggagctcatt actgccttcc   2174

 ctcccaggga ggccccttca gagaggagag gccacaggag ctgcattgtg gggggacagg   2234

 ctcaagcaat tctgtcccca tcaaggggtc agctggagag acccaagacc ctatctgttc   2294

 accagggacc caaaatccaa ggggatgctt ccctctgccc tctttcctgc ccctccccat   2354

 catacctgca cccaccccag ccagggctcc ctgtccagaa ttcggttctc ctcaggacgc   2414

 caactcccag agctaaggac caaggagaag aacagcctct ccacccccaa gccaggcggt   2474

 tgaggaacat attgagaaag gttcagattg cagaaaccca gccctgcccc tgcctcctgc   2534

 atccagcccc caacatggtg ccaaagcttc cagaagccaa aaagcttctg atttttaagg   2594

 tagtgggcat ctctctccta atgacgaagc tgctcagcaa ctccacctgc ccgccgcagg   2654

 aaggagcagt cccctgctat ccctgcagcc actcccagca cacccgcaca cagccagcac   2714

 caccgccccc accgtgcact tctcctctct gggccttggc ttgggaccag gtacgaagga   2774

 tccccaagcc cttcaggcct gagatcagag ccagatcagc cttaagtcac ctcccatcca   2834

 agaacttggc ctaaaaatac tcccctattt ctaaccctca ggacggatct gatattaaat   2894

 gccttccctg ggaggaaggg tgctttcccc ctccctagag gtgcccattc cataccctgg   2954

 gagactgagg agagcattgg ctgaagccca gttcctttcc catccatccc caactccaat   3014

 aatcccccac tcctcgcagg tctcagtgtc atgctgtctt ggggcagggt gaaagggtag   3074

 tggcagcagg gcgcccactc tggagatcct caaaaaaggc cctcctctgt ggctggcagc   3134

 ctctgacctt tccctgggct tcaaaggaag gctatggagt ttgctgtggg ccctgcaacc   3194

 ttcccagcca ctcctgctgc actaaggact taggatcctt ttatcacaaa tcgggattct   3254

 ctcccccacc ccgaattctg tctgcttaaa ctggaataca caggagccct tcctggcctg   3314

 gatggtgtct cccagcttcc ccgcccagct tgcccacccc atagttggtg agatgccaag   3374

 tttggtctga gttgtgaccc cttcagagta gatgcccggc aggctggggt tggcccctgg   3434

 agggtcaggg gaccatcttc ttattccctc ttttctcatt cctccaactt cctcccctcc   3494

 ttcaattatt tttttgtaaa gttgatgcct tactttttgg ataaatattt ttgaagctgg   3554

 tatttctatt tcttttggat tttttttaat gtaaggttgt tttgggggat ggagttagaa   3614

 ccttaatgat aatttctttc gtttggtgta ggttttagag atttgttttg tggagaggtt   3674

 tttttctttt gatgtaataa aatttaaaat ggaaatgaaa aaaaaaaaaa a            3725




      <210> 73
      <211> 3649
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(2656)

      <400> 73
 ggcacgagcg gcacgaggaa atgtgttgcc ggccttgtgg ggttccctag gtctgcggaa     60

 cggcaccgtc gggggacgtt ggataacagg atgatactgg agggattctt gtggttggag    120

 atcaggcctg ggttctgagg aaaacgca   atg gtg gcc atg gac ttg ggc tct     172
                                  Met Val Ala Met Asp Leu Gly Ser
                                    1               5

 ccc tcg ctc cct aag aag agc ctg cct gtc cct ggg gcc ctg gag cag      220
 Pro Ser Leu Pro Lys Lys Ser Leu Pro Val Pro Gly Ala Leu Glu Gln
      10                  15                  20

 gtg gcc agt cga ctg agc agc aaa gtg gct gca gag gtt cct cat ggc      268
 Val Ala Ser Arg Leu Ser Ser Lys Val Ala Ala Glu Val Pro His Gly
  25                  30                  35                  40

 agc aaa cag gag ctg cag gac ctc aag gcc cag agc ctg acc acc tgc      316
 Ser Lys Gln Glu Leu Gln Asp Leu Lys Ala Gln Ser Leu Thr Thr Cys
                  45                  50                  55

 gag gtc tgc ggt gcc tgc ttt gag acc cga aag ggc ctg tcc agc cac      364
 Glu Val Cys Gly Ala Cys Phe Glu Thr Arg Lys Gly Leu Ser Ser His
              60                  65                  70

 gcg cgc tcc cac ctg cgg cag ctg gga gtg gca gag tcg gaa agc agc      412
 Ala Arg Ser His Leu Arg Gln Leu Gly Val Ala Glu Ser Glu Ser Ser
          75                  80                  85

 ggc gca ccc atc gac ctc ctc tac gag ctt gtg aag cag aag ggt ctg      460
 Gly Ala Pro Ile Asp Leu Leu Tyr Glu Leu Val Lys Gln Lys Gly Leu
      90                  95                 100

 cct gac gcc cac ctt ggg ctg ccc cca ggc ctg gct aag aag tcc agc      508
 Pro Asp Ala His Leu Gly Leu Pro Pro Gly Leu Ala Lys Lys Ser Ser
 105                 110                 115                 120

 tca ctg aag gag gtg gtc gcc ggg gcc ccc cgg ccc ggc ttg ctc agc      556
 Ser Leu Lys Glu Val Val Ala Gly Ala Pro Arg Pro Gly Leu Leu Ser
                 125                 130                 135

 ctg gcc aag ccc ttg gat gcc cct gct gtc aac aaa gcc atc aag tcg      604
 Leu Ala Lys Pro Leu Asp Ala Pro Ala Val Asn Lys Ala Ile Lys Ser
             140                 145                 150

 cct ccc ggc ttc tcg gcc aag ggc ctg ggc cac ccg ccc agc tct cca      652
 Pro Pro Gly Phe Ser Ala Lys Gly Leu Gly His Pro Pro Ser Ser Pro
         155                 160                 165

 ctc ctc aaa aag aca cca ctg gcc ctg gcg ggc tcc cct acc cct aag      700
 Leu Leu Lys Lys Thr Pro Leu Ala Leu Ala Gly Ser Pro Thr Pro Lys
     170                 175                 180

 aat cct gag gac aag agc ccc cag ctg tcc ctg agc ccc cgg ccg gcc      748
 Asn Pro Glu Asp Lys Ser Pro Gln Leu Ser Leu Ser Pro Arg Pro Ala
 185                 190                 195                 200

 tcc cca aag gca cag tgg cct cag tct gag gat gag ggg ccc ttg aac      796
 Ser Pro Lys Ala Gln Trp Pro Gln Ser Glu Asp Glu Gly Pro Leu Asn
                 205                 210                 215

 ctc acc tca ggc cca gag cca gca cga gac atc cgc tgc gag ttc tgt      844
 Leu Thr Ser Gly Pro Glu Pro Ala Arg Asp Ile Arg Cys Glu Phe Cys
             220                 225                 230

 ggt gag ttc ttc gag aac cgc aag ggc ctc tcg agc cac gcg cgc tcc      892
 Gly Glu Phe Phe Glu Asn Arg Lys Gly Leu Ser Ser His Ala Arg Ser
         235                 240                 245

 cat ctg cgg caa atg ggc gtg acc gag tgg tac gtc aat ggc tcg ccc      940
 His Leu Arg Gln Met Gly Val Thr Glu Trp Tyr Val Asn Gly Ser Pro
     250                 255                 260

 atc gac acg ctg cgg gag atc ctg aag aga cgg acc cag tct cgg cct      988
 Ile Asp Thr Leu Arg Glu Ile Leu Lys Arg Arg Thr Gln Ser Arg Pro
 265                 270                 275                 280

 ggt gga cct ccc aac cca cca ggg cca agc cca aaa gcc ctg gcc aag     1036
 Gly Gly Pro Pro Asn Pro Pro Gly Pro Ser Pro Lys Ala Leu Ala Lys
                 285                 290                 295

 atg atg ggc ggc gca ggt cct ggc agc tca ctg gaa gcc cgc agc ccc     1084
 Met Met Gly Gly Ala Gly Pro Gly Ser Ser Leu Glu Ala Arg Ser Pro
             300                 305                 310

 tcg gac ctt cac atc tca ccc ttg gcc aag aag ttg cca cca cca ccg     1132
 Ser Asp Leu His Ile Ser Pro Leu Ala Lys Lys Leu Pro Pro Pro Pro
         315                 320                 325

 ggc agc ccc ctg ggc cac tca cca act gcc tct cct cct cct acg gcc     1180
 Gly Ser Pro Leu Gly His Ser Pro Thr Ala Ser Pro Pro Pro Thr Ala
     330                 335                 340

 cga aag atg ttc cca ggc ctg gct gca ccc tcc ttg ccc aag aag ctg     1228
 Arg Lys Met Phe Pro Gly Leu Ala Ala Pro Ser Leu Pro Lys Lys Leu
 345                 350                 355                 360

 aag cct gaa caa ata cgg gtg gag atc aag cgg gag atg ctg ccg ggg     1276
 Lys Pro Glu Gln Ile Arg Val Glu Ile Lys Arg Glu Met Leu Pro Gly
                 365                 370                 375

 gcc ctt cat ggg gaa ctg cac cca tct gag ggt ccc tgg ggg gca cca     1324
 Ala Leu His Gly Glu Leu His Pro Ser Glu Gly Pro Trp Gly Ala Pro
             380                 385                 390

 cgg gaa gac atg aca ccc ctg aac ctg tcg tcc cgg gca gag ccg gtg     1372
 Arg Glu Asp Met Thr Pro Leu Asn Leu Ser Ser Arg Ala Glu Pro Val
         395                 400                 405

 cgc gac atc cgc tgt gag ttc tgc ggc gag ttc ttc gag aac cgc aag     1420
 Arg Asp Ile Arg Cys Glu Phe Cys Gly Glu Phe Phe Glu Asn Arg Lys
     410                 415                 420

 ggc ctg tcg agt cac gcg cgc tca cac ctg cgg cag atg ggt gtg acc     1468
 Gly Leu Ser Ser His Ala Arg Ser His Leu Arg Gln Met Gly Val Thr
 425                 430                 435                 440

 gag tgg tcc gtc aat ggt tcg ccc atc gac aca ctg cga gag atc ctc     1516
 Glu Trp Ser Val Asn Gly Ser Pro Ile Asp Thr Leu Arg Glu Ile Leu
                 445                 450                 455

 aag aag aag tcc aag ccg tgc ctc atc aag aag gag cca ccg gct gga     1564
 Lys Lys Lys Ser Lys Pro Cys Leu Ile Lys Lys Glu Pro Pro Ala Gly
             460                 465                 470

 gac ctg gcc cct gcc ctg gct gag gac ggg cct ccc acc gtg gcc cct     1612
 Asp Leu Ala Pro Ala Leu Ala Glu Asp Gly Pro Pro Thr Val Ala Pro
         475                 480                 485

 ggg ccc gtg cag tcc cca ctg ccg ctg tcg ccc ctg gct ggc cgg cca     1660
 Gly Pro Val Gln Ser Pro Leu Pro Leu Ser Pro Leu Ala Gly Arg Pro
     490                 495                 500

 ggc aaa cca ggt gca ggg ccg gcc cag gtt cct cgt gag ctc agc ctg     1708
 Gly Lys Pro Gly Ala Gly Pro Ala Gln Val Pro Arg Glu Leu Ser Leu
 505                 510                 515                 520

 acg ccc atc act ggg gcc aag ccc tca gcc act ggc tac ctg ggc tca     1756
 Thr Pro Ile Thr Gly Ala Lys Pro Ser Ala Thr Gly Tyr Leu Gly Ser
                 525                 530                 535

 gtg gca gcc aag cgg ccc ctg cag gag gac cgc ctc ctc cca gca gag     1804
 Val Ala Ala Lys Arg Pro Leu Gln Glu Asp Arg Leu Leu Pro Ala Glu
             540                 545                 550

 gtc aag gcc aag acc tac atc cag act gaa ctg ccc ttc aag gca aag     1852
 Val Lys Ala Lys Thr Tyr Ile Gln Thr Glu Leu Pro Phe Lys Ala Lys
         555                 560                 565

 acc ctt cat gag aag acc tcc cac tcc tcc acc gag gcc tgc tgc gag     1900
 Thr Leu His Glu Lys Thr Ser His Ser Ser Thr Glu Ala Cys Cys Glu
     570                 575                 580

 ctg tgt ggc ctt tac ttt gaa aac cgc aag gcc ctg gcc agc cac gca     1948
 Leu Cys Gly Leu Tyr Phe Glu Asn Arg Lys Ala Leu Ala Ser His Ala
 585                 590                 595                 600

 cgg gca cac ctg cgg cag ttc ggc gtg acc gag tgg tgc gtc aat ggc     1996
 Arg Ala His Leu Arg Gln Phe Gly Val Thr Glu Trp Cys Val Asn Gly
                 605                 610                 615

 tcg ccc atc gag aca ctg agc gag tgg atc aaa cac cgg ccc cag aag     2044
 Ser Pro Ile Glu Thr Leu Ser Glu Trp Ile Lys His Arg Pro Gln Lys
             620                 625                 630

 gtg ggc gcc tac cgc agc tac atc cag ggc ggc cgc ccc ttc acc aag     2092
 Val Gly Ala Tyr Arg Ser Tyr Ile Gln Gly Gly Arg Pro Phe Thr Lys
         635                 640                 645

 aag ttc cgc agt gcc ggc cat ggc cgt gac agt gac aag cgg ccg tcc     2140
 Lys Phe Arg Ser Ala Gly His Gly Arg Asp Ser Asp Lys Arg Pro Ser
     650                 655                 660

 ctg ggg ctg gca ccc ggg ggc ctg gcc gtg gtc ggc cgc agt gcc gga     2188
 Leu Gly Leu Ala Pro Gly Gly Leu Ala Val Val Gly Arg Ser Ala Gly
 665                 670                 675                 680

 ggg gag cca ggg ccc gag gct ggc cgg gca gcc gac ggt ggt gag cgg     2236
 Gly Glu Pro Gly Pro Glu Ala Gly Arg Ala Ala Asp Gly Gly Glu Arg
                 685                 690                 695

 cct ctg gca gcc agc ccg cca ggc acc gtg aag gct gag gag cac cag     2284
 Pro Leu Ala Ala Ser Pro Pro Gly Thr Val Lys Ala Glu Glu His Gln
             700                 705                 710

 cgg cag aac atc aac aaa ttt gaa cgc cga caa gcc cgc cct cca gat     2332
 Arg Gln Asn Ile Asn Lys Phe Glu Arg Arg Gln Ala Arg Pro Pro Asp
         715                 720                 725

 gcc tcc gca gcc cgg gga ggc gag gac acc aat gac cta cag cag aag     2380
 Ala Ser Ala Ala Arg Gly Gly Glu Asp Thr Asn Asp Leu Gln Gln Lys
     730                 735                 740

 ctg gag gag gtg cgg caa ccc cca ccc cga gtc cgg cca gtc ccc tcc     2428
 Leu Glu Glu Val Arg Gln Pro Pro Pro Arg Val Arg Pro Val Pro Ser
 745                 750                 755                 760

 ctg gtg ccc cgg ccc ccc cag aca tca ctt gtc aag ttc gtg ggc aac     2476
 Leu Val Pro Arg Pro Pro Gln Thr Ser Leu Val Lys Phe Val Gly Asn
                 765                 770                 775

 atc tac acc ctc aaa tgc agg ttc tgt gag gtg gaa ttc cag ggc ccc     2524
 Ile Tyr Thr Leu Lys Cys Arg Phe Cys Glu Val Glu Phe Gln Gly Pro
             780                 785                 790

 ctc tcc atc cag gaa gag tgg gtg cgg cac tta cag cgg cac atc ctg     2572
 Leu Ser Ile Gln Glu Glu Trp Val Arg His Leu Gln Arg His Ile Leu
         795                 800                 805

 gag atg aac ttc tcc aaa gcg gac ccc cca cct gag gag tcc cag gcc     2620
 Glu Met Asn Phe Ser Lys Ala Asp Pro Pro Pro Glu Glu Ser Gln Ala
     810                 815                 820

 ccg cag gca cag aca gcg gcg gca gag gct ccc taa caca aaagcattcc     2670
 Pro Gln Ala Gln Thr Ala Ala Ala Glu Ala Pro 
 825                 830                 835

 agatcccctc tcgtgccacc tctgtctcct cttcttcctc ctctgtgtcc tcgtccctct   2730

 tcctctttct ttccgtttcc aaaggagcaa gccaaaacct caaaccggcg ccccttgggg   2790

 gccgggcaca ctacagccag ggcgccggga gccagctagc tgcccttccc ccagcccgag   2850

 gactctgggg ccacagggtg tcttccttca gcccatgccc acctggtcca gcaggggcag   2910

 cagccaggtc tctgatggca gccggtctgg tcacagggga ggacagcact cccccgtcta   2970

 gcagccaggc agggcgatgt ctgccatccg tggccatttg caaagacccc aaagacccct   3030

 gttctggttc cctctctccc ccatgaatat cctctcacac acatgtacat gcgaacacac   3090

 acaacacgca cctcgtgaga cccgggacct gccccggacc cccagttcct gggttgaacg   3150

 accacatcat gccacggtgc ttgctcaggg gaagccacgc tccctctgtg gggcctgctg   3210

 gggcctggga gccccccact gagcccacaa tgccacggaa atccttgttg gctgcccccg   3270

 agaggggcct tcccagctgg gaagagctca gagctgacag ctgcctcctg ccatgtcaag   3330

 gccccccaaa gagcctcagg ggctctgggg ccctggaggg tggggttggg gggtgggact   3390

 ctcctccccc actcctgctc cctctccctt ttcactgttg ctttctatgt atagctccct   3450

 agacctttca cttttttaaa aacgcgtttt gtgtagagaa taaggaacgt ggatcttttt   3510

 attttgcaat cctgggccag ctagaagcca ggagctgatt gaccttttaa cttttttcag   3570

 tggccacatt ttggttatcg atgtacctag aagtatgtaa attagattaa atttctcttc   3630

 tggaaacaaa aaaaaaaaa                                                3649




      <210> 74
      <211> 1609
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1202)..(1456)

      <400> 74
 gttaagacag gaaacacatt tattgagagc acagtggggt gcgccaagcc ctgtgctttg     60

 gaaccgcatc acagcgcccc tcacaacagc cctgtgaggt aggtgaagga gcccacttcc    120

 cacatgcaga cactgaaggc tcaacagctc ccctaggcct cagggttcct gcggggtggg    180

 caggggtcca gcccacgggt ctgaccccag gtcacggcgt ccatcagtca gagggcgggt    240

 ctctactcaa ggggaggccc cgggtccaga gtctctgggt ccagcctgtc ccgtgggaat    300

 aggtgcaggg tgtccccgtg gctgtggagg gatttcgagc tggagagggg ctggggtccc    360

 acattcgagg tcccttccca cgtaggcatc caggtgatgg cttccgccca aaccaggaag    420

 gagacgagag gcccgccagg aagaagactt gggtccggga tggtgggccc catcagggct    480

 cttccgcagc ttccatccgc agttcttcag ccgacccagc cgggccacgc ccacgtgcct    540

 ttgtgagcgt gcttccacgg agtagagcga gtcaggaagc agtgggttga agaggaaatt    600

 ggaggtgagg aaggaagaca gcaagtgtag acaggccttt caagaagctt ggctgatgca    660

 aggagagccc gtggacaagg gctgcctgga gtgctgttgg agaataaata agacaagtaa    720

 gacaagcaag aggggtggga agggactgac ctgtcaaacc ttttcaacaa acatttgctg    780

 atcacctcct ctatgccaga tcctgcctga ggcctctttt atctcattta attctcacaa    840

 caaccctagg aggttgctct catcgacccc attcccccag aaaaggatag gaagatcttc    900

 agagaggtgg ggcgtgcctt tggtgattca gtagcatgct cattccagaa gcccacccag    960

 ggccttggag ttgccagcag gatgctggcc aagcccttgg cccaggtccc cctcctgaga   1020

 atttcccaaa gggatccttc cattcaggac atcataaggg tgatgacaga gtcagtcgac   1080

 aaagactgac acccccttgg ggagggaaac actccagttt gctagcaggt gaacacaagc   1140

 aaagacttat aggaaagtac tcatagagtc aaagtatgag catagcaaag gtcagggctt   1200

 a    atg ccc aat gcc ccc tca cta ggg cat tgg ttt aag tct tta ggt    1246
      Met Pro Asn Ala Pro Ser Leu Gly His Trp Phe Lys Ser Leu Gly
        1               5                  10                  15

 aag agg gac agc tgg ctg gtc agt tcc ggt cct ctt cat cct ttg cca     1294
 Lys Arg Asp Ser Trp Leu Val Ser Ser Gly Pro Leu His Pro Leu Pro
                  20                  25                  30

 tcc tgg tcc tgg ggg tca gtg agt ggc tgc ttt gta tgt tgg tgg gat     1342
 Ser Trp Ser Trp Gly Ser Val Ser Gly Cys Phe Val Cys Trp Trp Asp
              35                  40                  45

 cca gga aac cgt gct cct agt gcc ctc gtg agg tgt aga tgg gca gca     1390
 Pro Gly Asn Arg Ala Pro Ser Ala Leu Val Arg Cys Arg Trp Ala Ala
          50                  55                  60

 ggc ccc ttg gca gca gct cag cat gga gag gag gtg gtc ctt gaa gac     1438
 Gly Pro Leu Ala Ala Ala Gln His Gly Glu Glu Val Val Leu Glu Asp
      65                  70                  75

 aag gag gtg gac gga tga tgtcat ccctgaggag agacccgggt gagggatcct     1492
 Lys Glu Val Asp Gly 
  80

 ctcgtgggcg ccccagctct cctgaggagc cgccgccaag gccagcgagc caaggcgcgc   1552

 tccctctctg ctctccgccg tctcgggggg gggggattaa tttaattaag gatcctt      1609




      <210> 75
      <211> 909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (333)..(905)

      <400> 75
 tgggctgttg ttgcggttgt tttccttctc tccgtgcaac gctggcaagt ctcaaagtcg     60

 ccacagaaac atgcccctga ttcagtgcct ctgcttagct gtaacatgtt aatcagaact    120

 acctggcatc ttcctgaaca agactttcaa taggggccag tatgcttcgc ttcatccaga    180

 agttttctca agcatcttca aagatactga agtactcttt cccagtggga ctaagaacca    240

 gcagaacaga tatactttct ctcaagatgt ctctccagca aaacttttcc ccatgtccaa    300

 ggccttggct ttcctcatca tttccagcgt at  atg agc aag aca cag tgc tat     353
                                      Met Ser Lys Thr Gln Cys Tyr
                                        1               5

 cat aca tcc ccc tgc agc ttt aaa aag cag cag aag caa gca ctt cta      401
 His Thr Ser Pro Cys Ser Phe Lys Lys Gln Gln Lys Gln Ala Leu Leu
          10                  15                  20

 gcc aga ccc tca agc acc atc act tac cta act gac agc cca aag cca      449
 Ala Arg Pro Ser Ser Thr Ile Thr Tyr Leu Thr Asp Ser Pro Lys Pro
      25                  30                  35

 gca tta tgt gta act ctg gca gga cta atc ccc ttc gtt gct cca cca      497
 Ala Leu Cys Val Thr Leu Ala Gly Leu Ile Pro Phe Val Ala Pro Pro
  40                  45                  50                  55

 ctg gtc atg ctg atg aca aaa act tat att ccc ata tta gct ttt act      545
 Leu Val Met Leu Met Thr Lys Thr Tyr Ile Pro Ile Leu Ala Phe Thr
                  60                  65                  70

 cag atg gct tat gga gcc agt ttc cta tct ttc ttg ggt ggg atc aga      593
 Gln Met Ala Tyr Gly Ala Ser Phe Leu Ser Phe Leu Gly Gly Ile Arg
              75                  80                  85

 tgg ggt ttt gct cta cca gaa ggt agt cca gcc aaa cca gac tac ctt      641
 Trp Gly Phe Ala Leu Pro Glu Gly Ser Pro Ala Lys Pro Asp Tyr Leu
          90                  95                 100

 aat tta gct agc agt gca gct cct ctt ttc ttt tca tgg ttt gcc ttc      689
 Asn Leu Ala Ser Ser Ala Ala Pro Leu Phe Phe Ser Trp Phe Ala Phe
     105                 110                 115

 ctt att tct gaa aga ctt agt gaa gcc ata gtc aca gta ata atg ggt      737
 Leu Ile Ser Glu Arg Leu Ser Glu Ala Ile Val Thr Val Ile Met Gly
 120                 125                 130                 135

 atg gga gta gca ttc cac ctt gaa ctt ttt ctc tta cca cat tat ccc      785
 Met Gly Val Ala Phe His Leu Glu Leu Phe Leu Leu Pro His Tyr Pro
                 140                 145                 150

 aac tgg ttt aaa gcc ctg agg ata gta gtc act tta ttg gcc act ttt      833
 Asn Trp Phe Lys Ala Leu Arg Ile Val Val Thr Leu Leu Ala Thr Phe
             155                 160                 165

 tca ttt ata atc act tta gta gtt aaa agt agt ttt cca gaa aaa gga      881
 Ser Phe Ile Ile Thr Leu Val Val Lys Ser Ser Phe Pro Glu Lys Gly
         170                 175                 180

 cat aag aga cct ggt caa gta taa aaaa                                 909
 His Lys Arg Pro Gly Gln Val 
     185                 190





      <210> 76
      <211> 2581
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(1075)

      <400> 76
 ccggaattcc cgggtcgact tcgctgtcga cgatttcgtc cggccctgct gccgacggag     60

 tcgccccggc gtccggattt aacacggaaa cccggatcgg aggccgcgcg gggaggagga    120

 gggcgacccg gtcggtcctg cgaccctctc ggcccggctc ggcgcctcgg cgggagcc      178                                                                 
 atg acc tcg ctg acc cag cgc agc tcc ggc ctg gtg cag cgg cgc acc      226
 Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr
   1               5                  10                  15

 gag gcc tcc cgc aac gcc gcc gac aag gag cgg gcg gcg ggc ggc ggc      274
 Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly
              20                  25                  30

 gcc ggc agc agc gag gac gac gcg cag agc cgc cgc gac gag cag gac      322
 Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp
          35                  40                  45

 gac gac gac aag ggc gac tcc aag gaa acg cgg ctg acc ctg atg gag      370
 Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu
      50                  55                  60

 gaa gtg ctc ctg ctg ggc ctc aag gac cgc gag ggt tac aca tca ttt      418
 Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr Ser Phe
  65                  70                  75                  80

 tgg aat gac tgt ata tca tct gga tta cgt ggc tgt atg tta att gaa      466
 Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu Ile Glu
                  85                  90                  95

 tta gca ttg aga gga agg tta caa cta gag gct tgt gga atg aga cgt      514
 Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met Arg Arg
             100                 105                 110

 aaa agt cta tta aca aga aag gta atc tgt aag tca gat gct cca aca      562
 Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala Pro Thr
         115                 120                 125

 ggg gat gtt ctt ctt gat gaa gct ctg aag cat gtt aag gaa act cag      610
 Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu Thr Gln
     130                 135                 140

 cct cca gaa acg gtc cag aac tgg att gaa tta ctt agt ggt gag aca      658
 Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly Glu Thr
 145                 150                 155                 160

 tgg aat cca tta aaa ttg cat tat cag tta aga aat gta cgg gaa cga      706
 Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg Glu Arg
                 165                 170                 175

 tta gct aaa aac ctg gtg gaa aag ggt gta ttg aca aca gag aaa cag      754
 Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu Lys Gln
             180                 185                 190

 aac ttc cta ctt ttt gac atg aca aca cat ccc ctc acc aat aac aac      802
 Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn Asn Asn
         195                 200                 205

 att aag cag cgc ctc atc aag aaa gta cag gaa gcc gtt ctt gac aaa      850
 Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu Asp Lys
     210                 215                 220

 tgg gtg aat gac cct cac cgc atg gac agg cgc ttg ctg gcc ctc att      898
 Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala Leu Ile
 225                 230                 235                 240

 tac ctg gct cat gcc tcg gac gtc ctg gag aat gct ttt gct cct ctt      946
 Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala Pro Leu
                 245                 250                 255

 ctg gac gag cag tat gat ttg gct acc aag aga gtg cgg cag ctt ctc      994
 Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln Leu Leu
             260                 265                 270

 gac tta gac cct gaa gtg gaa tgt ctg aag gcc aac acc aat gag gtt     1042
 Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn Glu Val
         275                 280                 285

 ctg tgg gcg gtg gtg gcg gcg ttc acc aag taa ctctgctc ggggtgaacc     1093
 Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
     290                 295

 attctccttt ctctcaagta aaccagtagt ttttcttctg ttgacttctg gttttctgta   1153

 atttgtactt tcccacacta taattggctt ctgttttaca aaatggtggg tggctttttc   1213

 ttttttgtac gtgtacagga ttctgctggt acgagaggcc ttcctctttc tgtttttaaa   1273

 aaaagtttta ctgccatatt ggcattccat tccctgttgc catcctcact gttacctgtt   1333

 ttgggtttct ggtctacttt gactttcaaa gtacctccag cctcctcata cgcacagctt   1393

 ttggatgacc tcagcttgag tttctccata tgtgcatgta catctagcat tctgcctaca   1453

 gttcagacag aagtcacaaa aaggccttca actcaccaaa ggtaaatatc tgtatctatt   1513

 aggacatttt ttacatagac ttcagttgag atgtatactt agcaaaatta tttttaaatt   1573

 gaaacagcac agtaaatact taatataaaa tgtcccttgg attttgcttc ccatgtaaat   1633

 ctattgtatt attacacttg ttataatttt aactataaag gtccaattgt ttcacagagc   1693

 cagtttggga tgggctgcat tccatttatg ctgtatatag tttgaattat atataaatta   1753

 ccccttcttc tggccacccc tgctcccatc ttagtatttt gcaagatcta atcagttgta   1813

 cacctggtgc ccctcgcttg cttcaatcat ggttatttga tggcaaaatc gacctcttgt   1873

 cgctgaagga gagagaaaag atgtgtgtct gattggtcct gggatttttt gagctgtgcc   1933

 atttatggta ctctttgcct atgcatcccc tttttagatt ttttttaaat tttatcttac   1993

 tgtttttata atttctattg ggaagaggct tgtgaccagt accaatcttg agtttctttt   2053

 tctgtccaca agtaaattaa tatctgctct gaaatgtcat ttatctactc acacattctt   2113

 ggggaaaaaa atcaaatgtc agtcctagca gatgttgcat gtaaattggt agcaagtaat   2173

 gattacaacc cagaggatta agaattttgt aacagaaagc tctatgtttt aattttttat   2233

 atacaattag gataattagc attgtcagac tataaacctt tgctttttaa agtttatttt   2293

 tactatttct ttatcacttt attgtatcat caccattggt ttcataatgt aaatactata   2353

 tgttgaacaa attaaatgtc aaaatttttt attaccatag tccatgttaa tagtggggct   2413

 ttcaggtgtt tagagatttt ttttgttgtt gttaacattc attgcaaaag tactagatgg   2473

 tgtataactc tagagttgaa ttttaaggga ttccctaata tgtatactat ctttttatct   2533

 gaagtaataa ataaacaatg atcttgaaag tgcctgaaaa aaaaaaaa                2581




      <210> 77
      <211> 755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(735)

      <400> 77
 gatcccaagg cccaactccc cgaaccactc agggtcctgt ggacagctca cctagtggca     60
                                                                 
 atg gct cca ggc tcc cgg acg tcc ctg ctc ctg gct ttt gcc ctg ctc      108
 Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15

 tgc ctg ccc tgg ctt caa gag gct ggt gcc gtc caa acc gtt ccg tta      156
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30

 tcc agg ctt ttt gac cac gct atg ctc caa gcc cat cgc gcg cac cag      204
 Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45

 ctg gcc att gac acc tac cag gag ttt gaa gaa acc tat atc cca aag      252
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys
      50                  55                  60

 gac cag aag tat tca ttc ctg cat gac tcc cag acc tcc ttc tgc ttc      300
 Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe
  65                  70                  75                  80

 tca gac tct att ccg aca ccc tcc aac atg gag gaa acg caa cag aaa      348
 Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys
                  85                  90                  95

 tcc aat cta gag ctg ctc cgc atc tcc ctg ctg ctc atc gag tcg tgg      396
 Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp
             100                 105                 110

 ctg gag ccc gtg cgg ttc ctc agg agt atg ttc gcc aac aac ctg gtg      444
 Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val
         115                 120                 125

 tat gac acc tcg gac agc gat gac tat cac ctc cta aag gac cta gag      492
 Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu
     130                 135                 140

 gaa ggc atc caa acg ctg atg ggg agg ctg gaa gac ggc agc cgc cgg      540
 Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg
 145                 150                 155                 160

 act ggg cag atc ctc aag cag acc tac agc aag ttt gac aca aac tca      588
 Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser
                 165                 170                 175

 cac aac cat gac gca ctg ctc aag aac tac ggg ctg ctc tac tgc ttc      636
 His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe
             180                 185                 190

 agg aag gac atg gac aag gtc gag aca ttc ctg cgc atg gtg cag tgc      684
 Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys
         195                 200                 205

 cgc tct gta gag ggt agc tgt ggt tct agg tgc ccg ctt ggc atc ctg      732
 Arg Ser Val Glu Gly Ser Cys Gly Ser Arg Cys Pro Leu Gly Ile Leu
     210                 215                 220

 tga ccgacccctt cccagtggct                                            755
 






      <210> 78
      <211> 2982
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (322)..(2340)

      <400> 78
 tcccgggtcg acccacgcgt ccggaaactg aacaaacaaa aacactttga tttattaaat     60

 tattaatcaa aatgccagta aactttgaat atattgtaat gaaaggaaat cctttatagg    120

 gtacaaagca ttgtcttaga cttttacgca tgttttattt tgtattttat aggcaactcc    180

 aatgaaatag acatcgtgca tcatgtagac actgaggcca atatagctac ggaggtttgc    240

 ctcactattc tggacctgtt atccctcttc acacagactc atcagagaca actccaacaa    300

 tgtgactgtc aaaattcatt g  atg aaa agg gtc ttt gat acc tac atg ctc     351
                          Met Lys Arg Val Phe Asp Thr Tyr Met Leu
                            1               5                  10

 ttt ttc caa gtc aat cag tca gcc aca gcg ctg aag cat gtg ttt gcc      399
 Phe Phe Gln Val Asn Gln Ser Ala Thr Ala Leu Lys His Val Phe Ala
                  15                  20                  25

 tcc ttg aga ctg ttt gta tgc aag ttt cct tca gcg ttc ttt caa ggg      447
 Ser Leu Arg Leu Phe Val Cys Lys Phe Pro Ser Ala Phe Phe Gln Gly
              30                  35                  40

 cct gct gac ctc tgt gga tca ttc tgt tac gaa gtc cta aaa tgc tgt      495
 Pro Ala Asp Leu Cys Gly Ser Phe Cys Tyr Glu Val Leu Lys Cys Cys
          45                  50                  55

 aac cac agg tca cgg tca act cag aca gaa gcc tca gcc ctt ctg tac      543
 Asn His Arg Ser Arg Ser Thr Gln Thr Glu Ala Ser Ala Leu Leu Tyr
      60                  65                  70

 ctt ttc atg agg aag aat ttt gaa ttt aac aag cag aag tca att gtc      591
 Leu Phe Met Arg Lys Asn Phe Glu Phe Asn Lys Gln Lys Ser Ile Val
  75                  80                  85                  90

 cgg tcc cac tta caa ctc atc aaa gct gtg agc cag tta ata gcc gat      639
 Arg Ser His Leu Gln Leu Ile Lys Ala Val Ser Gln Leu Ile Ala Asp
                  95                 100                 105

 gct ggg att gga ggc tct cgg ttt caa cat tcg ctt gca att acc aat      687
 Ala Gly Ile Gly Gly Ser Arg Phe Gln His Ser Leu Ala Ile Thr Asn
             110                 115                 120

 aat ttc gcc aat gga gat aag caa atg aaa aac agc aat ttc cca gca      735
 Asn Phe Ala Asn Gly Asp Lys Gln Met Lys Asn Ser Asn Phe Pro Ala
         125                 130                 135

 gag gtg aag gac ctg act aag cgt ata agg act gtt ttg atg gcc aca      783
 Glu Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val Leu Met Ala Thr
     140                 145                 150

 gct cag atg aag gag cac gag aag gac ccc gag atg ctg gtg gat ctc      831
 Ala Gln Met Lys Glu His Glu Lys Asp Pro Glu Met Leu Val Asp Leu
 155                 160                 165                 170

 cag tac agc ctg gca aac tcc tac gca agc act cct gaa cta cgc agg      879
 Gln Tyr Ser Leu Ala Asn Ser Tyr Ala Ser Thr Pro Glu Leu Arg Arg
                 175                 180                 185

 acc tgg ctg gaa agt atg gcc aag att cat gcc aga aac gga gat tta      927
 Thr Trp Leu Glu Ser Met Ala Lys Ile His Ala Arg Asn Gly Asp Leu
             190                 195                 200

 tct gag gct gcc atg tgt tac atc cat att gct gct ctc att gca gag      975
 Ser Glu Ala Ala Met Cys Tyr Ile His Ile Ala Ala Leu Ile Ala Glu
         205                 210                 215

 tat ctg aaa aga aag ggt tac tgg aaa gtg gaa aag att tgc aca gca     1023
 Tyr Leu Lys Arg Lys Gly Tyr Trp Lys Val Glu Lys Ile Cys Thr Ala
     220                 225                 230

 tcc ctg ctc tcg gag gat acc cac ccc tgt gat agc aac tca tta cta     1071
 Ser Leu Leu Ser Glu Asp Thr His Pro Cys Asp Ser Asn Ser Leu Leu
 235                 240                 245                 250

 aca act ccc agt gga gga agc atg ttc tct atg gga tgg cca gct ttt     1119
 Thr Thr Pro Ser Gly Gly Ser Met Phe Ser Met Gly Trp Pro Ala Phe
                 255                 260                 265

 ttg agc att aca cca aac att aag gaa gaa gga gcg atg aaa gag gat     1167
 Leu Ser Ile Thr Pro Asn Ile Lys Glu Glu Gly Ala Met Lys Glu Asp
             270                 275                 280

 tct gga atg caa gat aca cca tac aat gag aat atc ctg gtg gag cag     1215
 Ser Gly Met Gln Asp Thr Pro Tyr Asn Glu Asn Ile Leu Val Glu Gln
         285                 290                 295

 cta tac atg tgt gtg gag ttt ctc tgg aag tct gag cga tat gaa ctc     1263
 Leu Tyr Met Cys Val Glu Phe Leu Trp Lys Ser Glu Arg Tyr Glu Leu
     300                 305                 310

 att gct gat gtc aac aag ccc atc att gct gtc ttt gag aaa caa cga     1311
 Ile Ala Asp Val Asn Lys Pro Ile Ile Ala Val Phe Glu Lys Gln Arg
 315                 320                 325                 330

 gac ttc aaa aaa ttg tca gat ctc tac tac gac att cat cgg tca tat     1359
 Asp Phe Lys Lys Leu Ser Asp Leu Tyr Tyr Asp Ile His Arg Ser Tyr
                 335                 340                 345

 ctg aaa gtg gca gag gtg gtg aat tcg gag aag cgg ctg ttt ggt cgc     1407
 Leu Lys Val Ala Glu Val Val Asn Ser Glu Lys Arg Leu Phe Gly Arg
             350                 355                 360

 tac tat cgt gtg gca ttt tat ggg cag ggc ttt ttt gaa gaa gaa gaa     1455
 Tyr Tyr Arg Val Ala Phe Tyr Gly Gln Gly Phe Phe Glu Glu Glu Glu
         365                 370                 375

 ggt aaa gag tat att tat aaa gag cct aag ctg aca ggt ctg tcc gag     1503
 Gly Lys Glu Tyr Ile Tyr Lys Glu Pro Lys Leu Thr Gly Leu Ser Glu
     380                 385                 390

 att tcc caa aga tta ctc aag ctc tat gca gat aaa ttt gga gca gac     1551
 Ile Ser Gln Arg Leu Leu Lys Leu Tyr Ala Asp Lys Phe Gly Ala Asp
 395                 400                 405                 410

 aat gtg aag ata atc cag gat tcc aac aag gta aac ccc aag gat ttg     1599
 Asn Val Lys Ile Ile Gln Asp Ser Asn Lys Val Asn Pro Lys Asp Leu
                 415                 420                 425

 gac ccc aaa tat gcc tac atc cag gtg acc tat gtg acg ccg ttc ttt     1647
 Asp Pro Lys Tyr Ala Tyr Ile Gln Val Thr Tyr Val Thr Pro Phe Phe
             430                 435                 440

 gag gaa aag gaa atc gaa gac cgg aag aca gat ttc gaa atg cac cac     1695
 Glu Glu Lys Glu Ile Glu Asp Arg Lys Thr Asp Phe Glu Met His His
         445                 450                 455

 aac atc aac cgc ttt gtc ttc gag aca ccc ttc acg ctg tcg ggc aag     1743
 Asn Ile Asn Arg Phe Val Phe Glu Thr Pro Phe Thr Leu Ser Gly Lys
     460                 465                 470

 aag cac ggt ggg gtg gcg gag cag tgc aag cgg cgg acg atc ctg aca     1791
 Lys His Gly Gly Val Ala Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr
 475                 480                 485                 490

 acg agt cac ctg ttc ccc tac gtg aag aag aga ata caa gta att agc     1839
 Thr Ser His Leu Phe Pro Tyr Val Lys Lys Arg Ile Gln Val Ile Ser
                 495                 500                 505

 caa tcg agc aca gaa ctg aat cca att gaa gtg gca att gac gag atg     1887
 Gln Ser Ser Thr Glu Leu Asn Pro Ile Glu Val Ala Ile Asp Glu Met
             510                 515                 520

 tcc aag aag gtt tct gag ctt aat cag ctt tgc aca atg gaa gaa gtg     1935
 Ser Lys Lys Val Ser Glu Leu Asn Gln Leu Cys Thr Met Glu Glu Val
         525                 530                 535

 gac atg atc aga ctg cag ctc aaa ctg caa gga agt gtc agc gtg aag     1983
 Asp Met Ile Arg Leu Gln Leu Lys Leu Gln Gly Ser Val Ser Val Lys
     540                 545                 550

 gtt aat gct ggg cca atg gcc tat gca cga gct ttt ctt gaa gaa acc     2031
 Val Asn Ala Gly Pro Met Ala Tyr Ala Arg Ala Phe Leu Glu Glu Thr
 555                 560                 565                 570

 aat gca aag aag tac cct gac aac caa gta aag ctt ttg aag gag atc     2079
 Asn Ala Lys Lys Tyr Pro Asp Asn Gln Val Lys Leu Leu Lys Glu Ile
                 575                 580                 585

 ttc agg caa ttt gca gat gca tgt ggg cag gcc ctt gac gtg aat gag     2127
 Phe Arg Gln Phe Ala Asp Ala Cys Gly Gln Ala Leu Asp Val Asn Glu
             590                 595                 600

 cgc ctc atc aaa gag gac cag ctg gag tac cag gaa gaa ctg agg tcc     2175
 Arg Leu Ile Lys Glu Asp Gln Leu Glu Tyr Gln Glu Glu Leu Arg Ser
         605                 610                 615

 cac tac aag gac atg ctc agc gaa ctc tcc aca gtc atg aat gag cag     2223
 His Tyr Lys Asp Met Leu Ser Glu Leu Ser Thr Val Met Asn Glu Gln
     620                 625                 630

 att acg ggc agg gac gac ctg tca aag cgc gga gtg gac caa acc tgc     2271
 Ile Thr Gly Arg Asp Asp Leu Ser Lys Arg Gly Val Asp Gln Thr Cys
 635                 640                 645                 650

 act cga gta att agc aaa gca act ccg gcc cta ccc acg gtc tcc atc     2319
 Thr Arg Val Ile Ser Lys Ala Thr Pro Ala Leu Pro Thr Val Ser Ile
                 655                 660                 665

 tca tct agt gct gaa gtc tga gg gctctgcagc atcagaccca cctctaagag     2372
 Ser Ser Ser Ala Glu Val 
             670

 aactttctga atttgcagct aatctcgggg aagagaaaga taggtttaat ttatttgaag   2432

 ttttcatggt gttaatattt ttgtttacct cgctagcttc agaattttgc caacctctga   2492

 atttgcacat tttgtataat ttttttttct ttgagcagtg ttgatcaagc caagttgaat   2552

 atttgccatg aaattccagt gaatgtgtag ctcaaatgca aaccctaagt ttgctgtcag   2612

 ttattgtatg gtcagtaccc cagtcctagt acacatattt taaaggttaa agtgaatgtt   2672

 tttgtaacat ttaagcatat ttcagatgta aataaaagat tgtaaaatat acggttttta   2732

 ccaaatttaa aagatccttt ttagttaata ctatgacagt actaaaaata tatgaataac   2792

 atttcagata ccattatatt aaaatatttg tgtatgtgta caaaagcgtt gataaatact   2852

 aatctttaaa gtttgtggag ttcctttatt tgtaatatat gtgctcttaa aagcaatggg   2912

 atgtgaaatt atgaaagtat tttattgttc atagaaataa aaaacacagt tactttgcaa   2972

 aaaaaaaaaa                                                          2982




      <210> 79
      <211> 956
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (417)..(770)

      <400> 79
 tcgaatctaa taggatcact atagggaatt tgcatcctcg aggcaagcaa ttcggcacga     60

 ggggtattat agcttatata ttacatatgc ctataagtat tggttgaata aatgaatgaa    120

 tgaatgaatt cagagagtcc atgtgtttag aagcaggcca cacagcatct caaggtagaa    180

 aaacctctgg atcaacagga tggcaaatct gtggtaacca tgcctgtgtt cccactcctg    240

 cacccagggc agacatcact aatcaatccc agcattgttt ccaatgagca gcactcagag    300

 tccttgctcc ccgctgaaga tctgtatcta gagaggagca tgccatggtc cctggcaaca    360

 cccctgatct cagcccttcc ctgtaacttc ccacagcctc aatcctggtc ctctgg        416                                                                 
 atg ctc caa ggc tcc cag gca gct ctc tac atc cag aag att cca gag      464
 Met Leu Gln Gly Ser Gln Ala Ala Leu Tyr Ile Gln Lys Ile Pro Glu
   1               5                  10                  15

 cag cct caa aag aac cag gac ctt ctc ctg tca gtc cag ggt gtc cca      512
 Gln Pro Gln Lys Asn Gln Asp Leu Leu Leu Ser Val Gln Gly Val Pro
              20                  25                  30

 gac acc ttc cag gac ttc aac tgg tac ctg ggg gag gag acg tac gga      560
 Asp Thr Phe Gln Asp Phe Asn Trp Tyr Leu Gly Glu Glu Thr Tyr Gly
          35                  40                  45

 ggc acg agg cta ttt acc tac atc cct ggg ata caa cgg cct cag agg      608
 Gly Thr Arg Leu Phe Thr Tyr Ile Pro Gly Ile Gln Arg Pro Gln Arg
      50                  55                  60

 gat ggc agt gcc atg gga cag cga gac atc gtg ggc ttc ccc aat ggt      656
 Asp Gly Ser Ala Met Gly Gln Arg Asp Ile Val Gly Phe Pro Asn Gly
  65                  70                  75                  80

 tcc atg ctg ctg cgc cgc gcc cag cct aca gac agt ggc acc tac caa      704
 Ser Met Leu Leu Arg Arg Ala Gln Pro Thr Asp Ser Gly Thr Tyr Gln
                  85                  90                  95

 gta gcc att acc atc aac tct gaa tgg act atg aag gcc aag act gag      752
 Val Ala Ile Thr Ile Asn Ser Glu Trp Thr Met Lys Ala Lys Thr Glu
             100                 105                 110

 gtc cag gta gct gat tga aaaatg gaggcacgca gtggttatga cttgctgagt      806
 Val Gln Val Ala Asp 
         115

 aaagaatacg aaccagaatg atgtgacatg ggaaaggagg tcatcatgga gacctcactc    866

 aagaagtgac cttagaggag agaccagaag aagaaaagaa taaggagctg gccagtacac    926

 acctgcccac caacgctggg atactggcgg                                     956




      <210> 80
      <211> 1451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1410)

      <400> 80
 cggagatctc gccggcttta cgttcacctc ggtgtctgca gcaccctccg cttcctctcc     60

 taggcgacga gacccagtgg ctagaagttc acc atg tct att ctc aag atc cat     114
                                      Met Ser Ile Leu Lys Ile His
                                        1               5

 gcc agg gag atc ttt gac tct cgc ggg aat ccc act gtt gag gtt gat      162
 Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val Glu Val Asp
          10                  15                  20

 ctc ttc acc tca aaa ggt ctc ttc aga gct gct gtg ccc agt ggt gct      210
 Leu Phe Thr Ser Lys Gly Leu Phe Arg Ala Ala Val Pro Ser Gly Ala
      25                  30                  35

 tca act ggt atc tat gag gcc cta gag ctc cgg gac aat gat aag act      258
 Ser Thr Gly Ile Tyr Glu Ala Leu Glu Leu Arg Asp Asn Asp Lys Thr
  40                  45                  50                  55

 cgc tat atg ggg aag ggt gtc tca aag gct gtt gag cac atc aat aaa      306
 Arg Tyr Met Gly Lys Gly Val Ser Lys Ala Val Glu His Ile Asn Lys
                  60                  65                  70

 act att gcg cct gcc ctg gtt agc aag aaa ctg aac gtc aca gaa caa      354
 Thr Ile Ala Pro Ala Leu Val Ser Lys Lys Leu Asn Val Thr Glu Gln
              75                  80                  85

 gag aag att gac aaa ctg atg atc gag atg gat gga aca gaa aat aaa      402
 Glu Lys Ile Asp Lys Leu Met Ile Glu Met Asp Gly Thr Glu Asn Lys
          90                  95                 100

 tct aag ttt ggt gcg aac gcc att ctg ggg gtg tcc ctt gcc gtc tgc      450
 Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys
     105                 110                 115

 aaa gct ggt gcc gtt gag aag ggg gtc ccc ctg tac cgc cac atc gct      498
 Lys Ala Gly Ala Val Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala
 120                 125                 130                 135

 gac ttg gct ggc aac tct gaa gtc atc ctg cca gtc ccg gcg ttc aat      546
 Asp Leu Ala Gly Asn Ser Glu Val Ile Leu Pro Val Pro Ala Phe Asn
                 140                 145                 150

 gtc atc aat ggc ggt tct cat gct ggc aac aag ctg gcc atg cag gag      594
 Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu
             155                 160                 165

 ttc atg atc ctc cca gtc ggt gca gca aac ttc agg gaa gcc atg cgc      642
 Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe Arg Glu Ala Met Arg
         170                 175                 180

 att gga gca gag gtt tac cac aac ctg aag aat gtc atc aag gag aaa      690
 Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile Lys Glu Lys
     185                 190                 195

 tat ggg aaa gat gcc acc aat gtg ggg gat gaa ggc ggg ttt gct ccc      738
 Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro
 200                 205                 210                 215

 aac atc ctg gag aat aaa gaa ggc ctg gag ctg ctg aag act gct att      786
 Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu Leu Lys Thr Ala Ile
                 220                 225                 230

 ggg aaa gct ggc tac act gat aag gtg gtc atc ggc atg gac gta gcg      834
 Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile Gly Met Asp Val Ala
             235                 240                 245

 gcc tcc gag ttc ttc agg tct ggg aag tat gac ctg gac ttc aag tct      882
 Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp Leu Asp Phe Lys Ser
         250                 255                 260

 ccc gat gac ccc agc agg tac atc tcg cct gac cag ctg gct gac ctg      930
 Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp Gln Leu Ala Asp Leu
     265                 270                 275

 tac aag tcc ttc atc aag gac tac cca gtg gtg tct atc gaa gat ccc      978
 Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val Ser Ile Glu Asp Pro
 280                 285                 290                 295

 ttt gac cag gat gac tgg gga gct tgg cag aag ttc aca gcc agt gca     1026
 Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys Phe Thr Ala Ser Ala
                 300                 305                 310

 gga atc cag gta gtg ggg gat gat ctc aca gtg acc aac cca aag agg     1074
 Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg
             315                 320                 325

 atc gcc aag gcc gtg aac gag aag tcc tgc aac tgc ctc ctg ctc aaa     1122
 Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn Cys Leu Leu Leu Lys
         330                 335                 340

 gtc aac cag att ggc tcc gtg acc gag tct ctt cag gcg tgc aag ctg     1170
 Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu Gln Ala Cys Lys Leu
     345                 350                 355

 gcc cag gcc aat ggt tgg ggc gtc atg gtg tct cat cgt tcg ggg gag     1218
 Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu
 360                 365                 370                 375

 act gaa gat acc ttc atc gct gac ctg gtt gtg ggg ctg tgc act ggg     1266
 Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu Cys Thr Gly
                 380                 385                 390

 cag atc aag act ggt gcc cct tgc cga tct gag cgc ttg gcc aag tac     1314
 Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr
             395                 400                 405

 aac cag ctc ctc aga att gaa gag gag ctg ggc agc aag gct aag ttt     1362
 Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly Ser Lys Ala Lys Phe
         410                 415                 420

 gcc ggc agg aac ttt cag aaa ccc ttg ggc caa gta agc tgt ggg tag     1410
 Ala Gly Arg Asn Phe Gln Lys Pro Leu Gly Gln Val Ser Cys Gly 
     425                 430                 435

 gtaaagcctt tggttacctg ttgggtacac agacccctcc c                       1451




      <210> 81
      <211> 1235
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(1116)

      <400> 81
 ccggtgggtc tacagcggaa gggagggagc gaaggtagga ggcagggctt gcctcactgg     60

 ccaccctccc aaccccaaga gcccagcccc     atg gtc ccc gcc gcc ggc gcg     111
                                      Met Val Pro Ala Ala Gly Ala
                                        1               5

 ctg ctg tgg gtc ctg ctg ctg aat ctg ggt ccc cgg gcg gcg ggg gcc      159
 Leu Leu Trp Val Leu Leu Leu Asn Leu Gly Pro Arg Ala Ala Gly Ala
          10                  15                  20

 caa ggc ctg acc cag act ccg acc gaa atg cag cgg gtc agt tta cgc      207
 Gln Gly Leu Thr Gln Thr Pro Thr Glu Met Gln Arg Val Ser Leu Arg
      25                  30                  35

 ttt ggg ggc ccc atg acc cgc agc tac cgg agc acc gcc cgg act ggt      255
 Phe Gly Gly Pro Met Thr Arg Ser Tyr Arg Ser Thr Ala Arg Thr Gly
  40                  45                  50                  55

 ctt ccc cgg aag aca agg ata atc cta gag gac gag aat gat gcc atg      303
 Leu Pro Arg Lys Thr Arg Ile Ile Leu Glu Asp Glu Asn Asp Ala Met
                  60                  65                  70

 gcc gac gcc gac cgc ctg gct gga cca gcg gct gcc gag ctc ttg gcc      351
 Ala Asp Ala Asp Arg Leu Ala Gly Pro Ala Ala Ala Glu Leu Leu Ala
              75                  80                  85

 gcc acg gtg tcc acc ggc ttt agc cgg tcg tcc gcc att aac gag gag      399
 Ala Thr Val Ser Thr Gly Phe Ser Arg Ser Ser Ala Ile Asn Glu Glu
          90                  95                 100

 gat ggg tct tca gaa gag ggg gtt gtg att aat gcc gga aag gat agc      447
 Asp Gly Ser Ser Glu Glu Gly Val Val Ile Asn Ala Gly Lys Asp Ser
     105                 110                 115

 acc agc aga gag ctt ccc agt gcg act ccc aat aca gcg ggg agt tcc      495
 Thr Ser Arg Glu Leu Pro Ser Ala Thr Pro Asn Thr Ala Gly Ser Ser
 120                 125                 130                 135

 agc acg agg ttt ata gcc aat agt cag gag cct gaa atc agg ctg act      543
 Ser Thr Arg Phe Ile Ala Asn Ser Gln Glu Pro Glu Ile Arg Leu Thr
                 140                 145                 150

 tca agc ctg ccg cgc tcc ccc ggg agg tct act gag gac ctg cca ggc      591
 Ser Ser Leu Pro Arg Ser Pro Gly Arg Ser Thr Glu Asp Leu Pro Gly
             155                 160                 165

 tcg cag gcc acc ctg agc cag tgg tcc aca cct ggg tct acc ccg agc      639
 Ser Gln Ala Thr Leu Ser Gln Trp Ser Thr Pro Gly Ser Thr Pro Ser
         170                 175                 180

 cgg tgg ccg tca ccc tca ccc aca gcc atg cca tct cct gag gat ctg      687
 Arg Trp Pro Ser Pro Ser Pro Thr Ala Met Pro Ser Pro Glu Asp Leu
     185                 190                 195

 cgg ctg gtg ctg atg ccc tgg ggc ccg tgg cac tgc cac tgc aag tcg      735
 Arg Leu Val Leu Met Pro Trp Gly Pro Trp His Cys His Cys Lys Ser
 200                 205                 210                 215

 ggc acc atg agc cgg agc cgg tct ggg aag ctg cac ggc ctt tcc ggg      783
 Gly Thr Met Ser Arg Ser Arg Ser Gly Lys Leu His Gly Leu Ser Gly
                 220                 225                 230

 cgc ctt cga gtt ggg gcg ctg agc cag ctc cgc acg gag cac aag cct      831
 Arg Leu Arg Val Gly Ala Leu Ser Gln Leu Arg Thr Glu His Lys Pro
             235                 240                 245

 tgc acc tat caa caa tgt ccc tgc aac cga ctt cgg gaa gag tgc ccc      879
 Cys Thr Tyr Gln Gln Cys Pro Cys Asn Arg Leu Arg Glu Glu Cys Pro
         250                 255                 260

 ctg gac aca agt ctc tgt act gac acc aac tgt gcc tct cag agc acc      927
 Leu Asp Thr Ser Leu Cys Thr Asp Thr Asn Cys Ala Ser Gln Ser Thr
     265                 270                 275

 acc agt acc agg acc acc act acc ccc ttc ccc acc atc cac ctc aga      975
 Thr Ser Thr Arg Thr Thr Thr Thr Pro Phe Pro Thr Ile His Leu Arg
 280                 285                 290                 295

 agc agt ccc agc ctg cca ccc gcc agc ccc tgc cca gcc ctg gct ttt     1023
 Ser Ser Pro Ser Leu Pro Pro Ala Ser Pro Cys Pro Ala Leu Ala Phe
                 300                 305                 310

 tgg aaa cgg gtc agg att ggc ctg gag gat att tgg aat agc ctc tct     1071
 Trp Lys Arg Val Arg Ile Gly Leu Glu Asp Ile Trp Asn Ser Leu Ser
             315                 320                 325

 tca gtg ttc aca gag atg caa cca ata gac aga aac cag agg taa tgg     1119
 Ser Val Phe Thr Glu Met Gln Pro Ile Asp Arg Asn Gln Arg 
         330                 335                 340

 ccacttcatc cacatgagga gatgtcagta tctcaacctc tcttgccctt tcaatcctag   1179

 cacccactag atatttttag tacagaaaaa caaaactgga aaacaaaaaa aaaaaa       1235




      <210> 82
      <211> 1931
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (499)..(867)

      <400> 82
 acacaaaagt cgtcacttgg cccttttgga aacagttgag tcaaaaagtc ttggccttct     60

 gctcattttt aaccagggcc tcacagaaaa cagtttcgca atccaactgg tacactggca    120

 tgaggttgta aatcctatct gggaaagcaa accagaaact tctacccttt ggtgttcaaa    180

 aatacttcat ttttcttaaa attgtctttt taaaactgta aaggtctgta aacattagtt    240

 ttagaacaat tgctccccaa taatttattt tacaaacagg aatatgaaaa ataaatggtg    300

 gtaggaggaa ggacccacta agaacaccat ttttaaattt tgctaagtaa ggacattgag    360

 ggaaaaaact caaactctga tctaccatca ttgtttaatg ttcggcaaac atgaagcatt    420

 ttaataccaa aaaaagtgag gagaataaat ctcagcataa aggaacaact ttttaaactg    480

 aatttagcac tatgaaaa  atg tac ctc att ttc tgt aat ttt agc gag ttt     531
                      Met Tyr Leu Ile Phe Cys Asn Phe Ser Glu Phe
                        1               5                  10

 ccc gcg gat gta cac tgg ccc cat gga ttg gcg ctg ggg atc acc agt      579
 Pro Ala Asp Val His Trp Pro His Gly Leu Ala Leu Gly Ile Thr Ser
              15                  20                  25

 tta gag gtg cca gtg cct tct gac aaa ggc cca tgg atc cat atg act      627
 Leu Glu Val Pro Val Pro Ser Asp Lys Gly Pro Trp Ile His Met Thr
          30                  35                  40

 gcc tgt ctg ttc ttt tta gag acg ggc cca cac tgc aga gaa gtg att      675
 Ala Cys Leu Phe Phe Leu Glu Thr Gly Pro His Cys Arg Glu Val Ile
      45                  50                  55

 gtg aag gtc tcc aac cct gtc atg ccc cca cct gcc acc ttg act tgg      723
 Val Lys Val Ser Asn Pro Val Met Pro Pro Pro Ala Thr Leu Thr Trp
  60                  65                  70                  75

 gag agg gac act cac aaa agc atg tca aat cga cat cca ttt ctt tct      771
 Glu Arg Asp Thr His Lys Ser Met Ser Asn Arg His Pro Phe Leu Ser
                  80                  85                  90

 ctt tcc ctc agg tct cag gga gtt ttc ctc ttc tcc tcg gac tct ttc      819
 Leu Ser Leu Arg Ser Gln Gly Val Phe Leu Phe Ser Ser Asp Ser Phe
              95                 100                 105

 tct caa ggc ctc ttc tac aaa aac ccc tgc cca gag ggt tac tgc taa      867
 Ser Gln Gly Leu Phe Tyr Lys Asn Pro Cys Pro Glu Gly Tyr Cys 
         110                 115                 120

 aatgaaactc ccgtgtctgt ccccttccct ggcccccaac tgacttgcct gcctctgctt    927

 gctgctgtcc ctgcctattc cccttcatgc tggctctaga aagatgcaat ctttttccca    987

 ggccccagcc tctctggcct ccctgccatc cagcttctag cctcccttct ctggaatcta   1047

 tggaagaatc atcaagcagc ttctggaaat ccaggagtct gtccttggtc atggtcatct   1107

 tcaacctgtc tgtgttcttg agaacgttca tgtgctccca gaaacattct ttttgtctgc   1167

 ctttcctggt ctggccacat ttgactgtgt cacttctctc ttttctcact cttctctgcc   1227

 ctccacagac ctccgtgctg ccaggacttc ctaacggaag ggcttggctg gctccccgaa   1287

 gccatccaga actggacccg agggacccag ctcaacttga atgtcctttt atctgcccag   1347

 gagatgggaa gatgctgaga ccatgcttca gtgctgtccc acatctgtct ttctgagttt   1407

 agacttggtt tttccattat attccattca actgattttt ccatgatatt ccacaatgtc   1467

 ttacctaact ctagctttct atactcaaca gcaatgcctc ctgagagcct cctgggtgtc   1527

 aagtactctg ttgtgtgctt ttgaggacta gggtgttagc aaggcacagt ctctgacttt   1587

 gcagggctca cagattcatg gggaaaattg atgttccagt tacagtgagg caaggcaatc   1647

 tggcagtaac tccatagaga ggaatgacag gctgggccta ggaatggagg ggagcgggta   1707

 atagaggatc ctaaggaaac tgagagaaga ggggctggag tgcggctggt ctgcgctcct   1767

 gtgcattgcc ttggctaaca ttttacttgt ccttctgaat caccctggca ttgtcaacaa   1827

 agaataatgt atgatccttc ttggagtaaa aagccttcag cagtgcttca caaaaaattc   1887

 tattgtatat tttgtgtcct acctcaaatt aattaaaaaa aaaa                    1931




      <210> 83
      <211> 1563
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(828)

      <400> 83
 gcaggtaccg cgtccggaat tcccgggtcg acgatttcgt cttcgctgcg acgatttcgt     60

 gccgccggtg gctcccgggt tgacgggact gttaggttgc gggctttggg gctcactccc    120

 gacggcattg tcttctcctc ttctcagaca gggcagaccg aggagtttgg accgagagtt    180

 tatagaaacc tattcaccaa a  atg gca tcc tgg tta tat gaa tgt ctt tgt     231
                          Met Ala Ser Trp Leu Tyr Glu Cys Leu Cys
                            1               5                  10

 gaa gct gaa ctt gca cag tat tat tct cat ttc act gcc ctt ggc ctt      279
 Glu Ala Glu Leu Ala Gln Tyr Tyr Ser His Phe Thr Ala Leu Gly Leu
                  15                  20                  25

 cag aaa ata gat gaa tta gcc aag att aca atg aag gac tac tcc aaa      327
 Gln Lys Ile Asp Glu Leu Ala Lys Ile Thr Met Lys Asp Tyr Ser Lys
              30                  35                  40

 tta gga gtc cat gac atg aac gac cgc aaa cgt ctc ttc caa ctt atc      375
 Leu Gly Val His Asp Met Asn Asp Arg Lys Arg Leu Phe Gln Leu Ile
          45                  50                  55

 aaa att att aag att atg caa gaa gaa gat aaa gca gtc agt atc cca      423
 Lys Ile Ile Lys Ile Met Gln Glu Glu Asp Lys Ala Val Ser Ile Pro
      60                  65                  70

 gag cgt cat ctt cag aca agc agc ctg cgc atc aaa tct cag gaa tta      471
 Glu Arg His Leu Gln Thr Ser Ser Leu Arg Ile Lys Ser Gln Glu Leu
  75                  80                  85                  90

 aga tct ggc cct cgc aga cag ctg aat ttt gat tct cct gct gac aat      519
 Arg Ser Gly Pro Arg Arg Gln Leu Asn Phe Asp Ser Pro Ala Asp Asn
                  95                 100                 105

 aaa gac aga aat gcc agc aat gat ggg ttt gaa atg tgc agt tta tca      567
 Lys Asp Arg Asn Ala Ser Asn Asp Gly Phe Glu Met Cys Ser Leu Ser
             110                 115                 120

 gat ttc tct gca aat gaa cag aag tcc act tac cta aaa gtg cta gaa      615
 Asp Phe Ser Ala Asn Glu Gln Lys Ser Thr Tyr Leu Lys Val Leu Glu
         125                 130                 135

 cac atg cta cca gat gat tcc cag tac cat aca aaa aca gga att ctg      663
 His Met Leu Pro Asp Asp Ser Gln Tyr His Thr Lys Thr Gly Ile Leu
     140                 145                 150

 aat gcc aca gct ggt gat tcc tat gtg caa aca gaa atc agc act tca      711
 Asn Ala Thr Ala Gly Asp Ser Tyr Val Gln Thr Glu Ile Ser Thr Ser
 155                 160                 165                 170

 ctc ttt tca cca aat tac ctt tct gca ata ctg ggg gat tgt gat att      759
 Leu Phe Ser Pro Asn Tyr Leu Ser Ala Ile Leu Gly Asp Cys Asp Ile
                 175                 180                 185

 ccc att att caa aga atc tct cat gtt tca ggg tat aac tat gga atc      807
 Pro Ile Ile Gln Arg Ile Ser His Val Ser Gly Tyr Asn Tyr Gly Ile
             190                 195                 200

 ccc cat tct tgt atc agg taa ta aattttatct ttctttcttt tgagggaaag      860
 Pro His Ser Cys Ile Arg 
         205

 tagcctcagg caagggcagg cctctccttc atgtccagca gacagcatct actccttatt    920

 tatagtaaat gaatataaca gaaattatca tgaacagcat ttgcatcaat aataggaata    980

 cctggatgtg ggaaaattaa tgagaaattg ggactttcta ggtgggagaa agatgatatt   1040

 gttcatgtac atcagaacag ctgctacttg ccaggatctg tagcagatct gtttctattg   1100

 tttattatag cgtaacatga tacatctagt acatctgtga aagtgaaata gttaaccctt   1160

 ctacagtgga gaaaaaaatt acacaatcca caggactttt ttaaggttat caaattcact   1220

 taacccaacc aggagactta aagatgcttt gttaaaaaac aagggcatgt agtttaatta   1280

 agtaggtctt tggggcagtt agttcaccta cacacattga aatatgatcc taattttgag   1340

 tgctttctac aatttcaacc ccggaaaaaa cagataattt tggtgattac aaacagtaag   1400

 acattgttgg tggagatgag agtttgagag tcagggtgac aataagttat ttttacctag   1460

 tgtttcgagt tagaatttga aataaggtcc ctaagaggtg aaataacaag taatccctag   1520

 tactaacaat ggtataatag gaaatatgtt cttttaatct tgt                     1563




      <210> 84
      <211> 1380
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(915)

      <400> 84
 ggaattccaa gcgcgtaatg gccgctggct atcttggggg agccagctgt tggactatgc     60

 cccactgcca ggaaacaggc gccggaaggt tctctgacaa gatctcgctt tcctagggcg    120

 gtgaaggcgt tcaaaggtcg ggaaggggcg ctgggagaag cggggcagcg ctgagcc       177                                                                 
 atg ctc gcg aac tgt ggg tct gtc tgt gaa gag acc cag ttt cgt ggg      225
 Met Leu Ala Asn Cys Gly Ser Val Cys Glu Glu Thr Gln Phe Arg Gly
   1               5                  10                  15

 acc acg gtg gcg cct gcg ctg gga gag ttc ttc act acc aca acc aag      273
 Thr Thr Val Ala Pro Ala Leu Gly Glu Phe Phe Thr Thr Thr Thr Lys
              20                  25                  30

 gag gga tat gat agg cgg cca gtg gat ata act cct tta gaa caa agg      321
 Glu Gly Tyr Asp Arg Arg Pro Val Asp Ile Thr Pro Leu Glu Gln Arg
          35                  40                  45

 aaa tta act ttt gat acc cat gca ttg gtt cag gac ttg gaa act cat      369
 Lys Leu Thr Phe Asp Thr His Ala Leu Val Gln Asp Leu Glu Thr His
      50                  55                  60

 gga ttt gac aaa aca caa gca gaa aca att gta tca gcg tta act gct      417
 Gly Phe Asp Lys Thr Gln Ala Glu Thr Ile Val Ser Ala Leu Thr Ala
  65                  70                  75                  80

 tta tca aat gtc agc ctg gat act atc tat aaa gag atg gtc act caa      465
 Leu Ser Asn Val Ser Leu Asp Thr Ile Tyr Lys Glu Met Val Thr Gln
                  85                  90                  95

 gct caa cag gaa ata aca gta caa cag cta atg gct cat ttg gat gct      513
 Ala Gln Gln Glu Ile Thr Val Gln Gln Leu Met Ala His Leu Asp Ala
             100                 105                 110

 atc agg aaa gac atg gtc atc cta gag aaa agt gaa ttt gca aat ctg      561
 Ile Arg Lys Asp Met Val Ile Leu Glu Lys Ser Glu Phe Ala Asn Leu
         115                 120                 125

 aga gca gag aat gag aaa atg aaa att gaa tta gac caa gtt aag caa      609
 Arg Ala Glu Asn Glu Lys Met Lys Ile Glu Leu Asp Gln Val Lys Gln
     130                 135                 140

 caa cta atg cat gaa acc agt cga atc aga gca gat aat aaa ctg gat      657
 Gln Leu Met His Glu Thr Ser Arg Ile Arg Ala Asp Asn Lys Leu Asp
 145                 150                 155                 160

 atc aac tta gaa agg agc aga gta aca gat atg ttt aca gat caa gaa      705
 Ile Asn Leu Glu Arg Ser Arg Val Thr Asp Met Phe Thr Asp Gln Glu
                 165                 170                 175

 aag caa ctt atg gaa aca act aca gaa ttt aca aaa aag gat act caa      753
 Lys Gln Leu Met Glu Thr Thr Thr Glu Phe Thr Lys Lys Asp Thr Gln
             180                 185                 190

 acc aaa agt att att tca gag acc agt aat aaa att gac gct gaa att      801
 Thr Lys Ser Ile Ile Ser Glu Thr Ser Asn Lys Ile Asp Ala Glu Ile
         195                 200                 205

 gct tcc tta aaa aca ctg atg gaa tct aac aaa ctt gag aca att cgt      849
 Ala Ser Leu Lys Thr Leu Met Glu Ser Asn Lys Leu Glu Thr Ile Arg
     210                 215                 220

 tat ctt gca gct tcg gtg ttt act tgc ctg gca ata gca ttg gga ttt      897
 Tyr Leu Ala Ala Ser Val Phe Thr Cys Leu Ala Ile Ala Leu Gly Phe
 225                 230                 235                 240

 tat aga ttc tgg aag tag tattaa tgctcatcct gctgtggctg ttggcttctt      951
 Tyr Arg Phe Trp Lys 
                 245

 agaacaccaa accgggagag atttactttg aacattgtca gttgcagcaa aaatttacta   1011

 cacaagatta ttcgaagtgt atacggacta aaagaggaag tgttttagaa tgagaagaga   1071

 tactgtgtct ttattgtgtg tgtgtgagtg caggtgtgtg tctttattat attgaaaagc   1131

 tgtcactcag acctggtttg agatagaaga gcattttgtc cttttgatag ttaatagaaa   1191

 ttgaaccaga gttttcttat gtttgcttga acagttgtgt aaatcataca ggattttgtg   1251

 ggtattggtt gaatatttgt aaaccattcc ctagcctaca tatttattac tgaattaact   1311

 ttcctgataa ccattgcata attacatttt tctataaaat gaaagattat tacaacaaaa   1371

 aaaaaaaaa                                                           1380




      <210> 85
      <211> 1869
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (282)..(1040)

      <400> 85
 ccggaatttc cgggtcgacg atctcgtcct gcctccagct caggtactag ggggtctaga     60

 cctgaggctg cccgggccgg aggcagcctt gagtcccgag accaaacgtc gtttccctct    120

 cggacctcgg gcgccgggcc gcgcgctgac cgacagcccc tgctaggccc agcaggtccc    180

 ctagtccccc gcagtccccc gagactcgcc gagcgccgtt gctgagccct gcaaatagca    240

 gcagggtggc cactgcaaca ggtgtggatg tgcctgacaa g    atg aag agc cga     293
                                                  Met Lys Ser Arg
                                                    1

 ata cct gtg gtg ctc ctg gcc tgt ggc tcc ttt aac ccc atc acc aac      341
 Ile Pro Val Val Leu Leu Ala Cys Gly Ser Phe Asn Pro Ile Thr Asn
   5                  10                  15                  20

 atg cac ctg cgc atg ttt gag gtg gcc aga gat cac cta cac caa aca      389
 Met His Leu Arg Met Phe Glu Val Ala Arg Asp His Leu His Gln Thr
                  25                  30                  35

 gga atg tac cag gtc atc cag ggt atc atc tct cct gtc aac gac acc      437
 Gly Met Tyr Gln Val Ile Gln Gly Ile Ile Ser Pro Val Asn Asp Thr
              40                  45                  50

 tat ggg aag aaa gac ctc gca gct tct cat cac cga gtg gcc atg gcc      485
 Tyr Gly Lys Lys Asp Leu Ala Ala Ser His His Arg Val Ala Met Ala
          55                  60                  65

 cgg ctg gcc ctg cag aca tcc gac tgg atc cgg gtg gac cct tgg gag      533
 Arg Leu Ala Leu Gln Thr Ser Asp Trp Ile Arg Val Asp Pro Trp Glu
      70                  75                  80

 agt gag cag gca cag tgg atg gag aca gtg aag gtg ctg agg cat cat      581
 Ser Glu Gln Ala Gln Trp Met Glu Thr Val Lys Val Leu Arg His His
  85                  90                  95                 100

 cac agc aaa ctg ctc aga tct cca ccc cag atg gaa ggc cca gac cat      629
 His Ser Lys Leu Leu Arg Ser Pro Pro Gln Met Glu Gly Pro Asp His
                 105                 110                 115

 ggc aag gca ctc ttc tcg acc cct gca gct gtg cct gag ctg aag ctt      677
 Gly Lys Ala Leu Phe Ser Thr Pro Ala Ala Val Pro Glu Leu Lys Leu
             120                 125                 130

 ctc tgt ggg gca gac gtc ttg aag acc ttc cag acc ccc aac ctc tgg      725
 Leu Cys Gly Ala Asp Val Leu Lys Thr Phe Gln Thr Pro Asn Leu Trp
         135                 140                 145

 aag gat gcg cac atc cag gaa ata gtg gag aag ttt ggc ttg gtg tgc      773
 Lys Asp Ala His Ile Gln Glu Ile Val Glu Lys Phe Gly Leu Val Cys
     150                 155                 160

 gtg ggc cga gta ggt cac gac cca aaa ggt tac atc gca gaa tct ccc      821
 Val Gly Arg Val Gly His Asp Pro Lys Gly Tyr Ile Ala Glu Ser Pro
 165                 170                 175                 180

 atc cta cgg atg cac cag cac aac att cac ctg gcc aag gag cct gtg      869
 Ile Leu Arg Met His Gln His Asn Ile His Leu Ala Lys Glu Pro Val
                 185                 190                 195

 cag aat gag atc aga gcc aca tac atc agg cga gcc ttg ggc caa ggg      917
 Gln Asn Glu Ile Arg Ala Thr Tyr Ile Arg Arg Ala Leu Gly Gln Gly
             200                 205                 210

 cag agc gta aag tac ctg att ccc gat gct gtc atc acg tac atc aag      965
 Gln Ser Val Lys Tyr Leu Ile Pro Asp Ala Val Ile Thr Tyr Ile Lys
         215                 220                 225

 gac cat ggc ctc tac acc aag ggc agt acc tgg aaa ggc aaa agc acc     1013
 Asp His Gly Leu Tyr Thr Lys Gly Ser Thr Trp Lys Gly Lys Ser Thr
     230                 235                 240

 cag agc act gag ggc aag aca agc tag ggagg ggggactcag cacccacacc     1065
 Gln Ser Thr Glu Gly Lys Thr Ser 
 245                 250

 tcctccaaca agctcctgct ggggagaggg ctgttaaggt ttctgtttta ctttggtttt   1125

 tgcttctcca tttttcattt gctttatttc tacagtgatt ctacttctga ggagtcttct   1185

 gtcccaggaa gagatacctt ctttacagga gaggaaaggt ctaaatcaca aggatagaca   1245

 tttatcaaag aagttaaaat ggtgtggcag gtcattagga ttaggcagaa tctctcagag   1305

 ctgctggaca aggaggtcta cttattttgt gtggatggta attatggcat gcacgctgaa   1365

 tgcagttctg agcatggcag cggcccctga gggtcagatc agaattgccc acaatgtgtt   1425

 ttttaactag gaccaggtgc agcatgctag tcttgattgg aaagatttga caggatgcta   1485

 attactgaac agtgggtttt gtcaacgccc tggtttcaga atatgaactg aggagtcaaa   1545

 cagttggaaa cagcacattg ctgatttaca ctggatcttg ccttagaaac cattgtctgc   1605

 ctgcctaacc agcctttcat aaaatttaaa caaaactctt tctacgtagt gatcctcaag   1665

 caatattttt gatacagcaa gtgtcaaact tgctatagca taaaagccgg ggctcctgat   1725

 ttccaggttt ctaaaatgaa ctgaggtaaa acagatgcct gaccgtttta aaggatcttt   1785

 tttaatgttt tatgactgcc tgtctgtttg aatactggca aagggataaa taataaattg   1845

 acatcaaaaa gtaaaaaaaa aaaa                                          1869




      <210> 86
      <211> 1009
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(827)

      <400> 86
 cagccgcctc ggccgccgca    atg cag aga gag gag aag cag ctt gag gca      50
                          Met Gln Arg Glu Glu Lys Gln Leu Glu Ala
                            1               5                  10

 tca tta gat gca ctg ctg agt caa gtg gct gat ctg aag aac tct ctg       98
 Ser Leu Asp Ala Leu Leu Ser Gln Val Ala Asp Leu Lys Asn Ser Leu
                  15                  20                  25

 ggg agt ttc att tgc aag ttg gag aac gag tat ggc cgg ctg acc tgg      146
 Gly Ser Phe Ile Cys Lys Leu Glu Asn Glu Tyr Gly Arg Leu Thr Trp
              30                  35                  40

 cca tct gtc ctg gac agc ttt gcc ttg ctt tct gga cag ctg aac act      194
 Pro Ser Val Leu Asp Ser Phe Ala Leu Leu Ser Gly Gln Leu Asn Thr
          45                  50                  55

 ctg aac aag gtc ttg aag cat gaa aaa aca ccg ctg ttc cgt aac cag      242
 Leu Asn Lys Val Leu Lys His Glu Lys Thr Pro Leu Phe Arg Asn Gln
      60                  65                  70

 gtc atc att cct ctg gtg ttg tct cca gac cga gat gaa gat ctc atg      290
 Val Ile Ile Pro Leu Val Leu Ser Pro Asp Arg Asp Glu Asp Leu Met
  75                  80                  85                  90

 cgg cag act gaa gga cgg gtg cct gtt ttc agc cat gag gta gtc cct      338
 Arg Gln Thr Glu Gly Arg Val Pro Val Phe Ser His Glu Val Val Pro
                  95                 100                 105

 gac cat ctg aga acc aag cct gac cct gaa gtg gaa gaa cag gag aag      386
 Asp His Leu Arg Thr Lys Pro Asp Pro Glu Val Glu Glu Gln Glu Lys
             110                 115                 120

 caa ctg acg aca gat gct gcc cgc att ggt gca gat gca gcc cag aag      434
 Gln Leu Thr Thr Asp Ala Ala Arg Ile Gly Ala Asp Ala Ala Gln Lys
         125                 130                 135

 cag atc cag agc ttg aat aaa atg tgt tca aac ctt ctg gag aaa atc      482
 Gln Ile Gln Ser Leu Asn Lys Met Cys Ser Asn Leu Leu Glu Lys Ile
     140                 145                 150

 agc aaa gag gag cga gaa tca gag agt gga ggt ctc cgg ccg aac aag      530
 Ser Lys Glu Glu Arg Glu Ser Glu Ser Gly Gly Leu Arg Pro Asn Lys
 155                 160                 165                 170

 cag acc ttt aac cct aca gac act aat gcc ttg gtg gca gct gtt gcc      578
 Gln Thr Phe Asn Pro Thr Asp Thr Asn Ala Leu Val Ala Ala Val Ala
                 175                 180                 185

 ttt ggg aaa gga cta tct aat tgg aga cct tca ggc agc agt ggt cct      626
 Phe Gly Lys Gly Leu Ser Asn Trp Arg Pro Ser Gly Ser Ser Gly Pro
             190                 195                 200

 ggc cag gca ggc cag cca gga gct ggg acg atc ctt gca gga acc tca      674
 Gly Gln Ala Gly Gln Pro Gly Ala Gly Thr Ile Leu Ala Gly Thr Ser
         205                 210                 215

 gga tta cag cag gtg cag atg gca gga gct cca agc cag cag cag cca      722
 Gly Leu Gln Gln Val Gln Met Ala Gly Ala Pro Ser Gln Gln Gln Pro
     220                 225                 230

 atg ctc agt ggg gta caa atg gct cag gca ggt caa cca ggg aaa atg      770
 Met Leu Ser Gly Val Gln Met Ala Gln Ala Gly Gln Pro Gly Lys Met
 235                 240                 245                 250

 cca agt gga ata aaa acc aac atc aag tcg gct tcc atg cat ccc tac      818
 Pro Ser Gly Ile Lys Thr Asn Ile Lys Ser Ala Ser Met His Pro Tyr
                 255                 260                 265

 cag cgg tga gtgtggc tggcaacctc gactccctgg tgctctttgc agagttgggc      874
 Gln Arg 


 agtgaaatta ccttttgctc aaggctcacc tagatgggta caataaaaag aacatgggct    934

 ttcagcagca gacaaatccc acttccacca ctgactagct gtgtgacctt ggacaagtga    994

 cctaaaaaaa aaaaa                                                    1009




      <210> 87
      <211> 1762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (580)..(1218)

      <400> 87
 tttcgttcca ctatgtctca ctgatggacc gtagcttgta cctaactccg agacaaacca     60

 ggcctacatt aagaggtgat ggtgaaccgg tatcatttgg tggaaggact tgctgtccgg    120

 cttacagggt gcaaggtctc agggttgatg ctgtctataa cccttatacc aaagatagaa    180

 aacaacctgg ctatcctatg ccaatgagat cctgtgttac ctgactggtg ttgcacacca    240

 tctccttggc tttccagccc tcctttctat gtgtcatact cgtttatctg ggtgaccaac    300

 ctgttcctat tggtgcagag agaggagaag cagcttgagg catcattaga tgcactgctg    360

 agtcaagtgg ctgatctgaa gaactctctg gggagtttca tttgcaagtt ggagaacgag    420

 tatggccggc tgacctggcc atctgtcctg gacagctttg ccttgctttc tggacagctg    480

 aacactctga acaaggtctt gaagcatgaa aaaacaccgc tgttccgtaa ccaggtcatc    540

 attcctctgg tgttgtctcc agaccgagat gaagatctc   atg cgg cag act gaa     594
                                              Met Arg Gln Thr Glu
                                                1               5

 gga cgg gtg cct gtt ttc agc cat gag gta gtc cct gac cat ctg aga      642
 Gly Arg Val Pro Val Phe Ser His Glu Val Val Pro Asp His Leu Arg
                  10                  15                  20

 acc aag cct gac cct gaa gtg gaa gaa cag gag aag caa ctg acg aca      690
 Thr Lys Pro Asp Pro Glu Val Glu Glu Gln Glu Lys Gln Leu Thr Thr
              25                  30                  35

 gat gct gcc cgc att ggt gca gat gca gcc cag aag cag atc cag agc      738
 Asp Ala Ala Arg Ile Gly Ala Asp Ala Ala Gln Lys Gln Ile Gln Ser
          40                  45                  50

 ttg aat aaa atg tgt tca aac ctt ctg gag aaa atc agc aaa gag gag      786
 Leu Asn Lys Met Cys Ser Asn Leu Leu Glu Lys Ile Ser Lys Glu Glu
      55                  60                  65

 cga gaa tca gag agt gga ggt ctc cgg ccg aac aag cag acc ttt aac      834
 Arg Glu Ser Glu Ser Gly Gly Leu Arg Pro Asn Lys Gln Thr Phe Asn
  70                  75                  80                  85

 cct aca gac act aat gcc ttg gtg gca gct gtt gcc ttt ggg aaa gga      882
 Pro Thr Asp Thr Asn Ala Leu Val Ala Ala Val Ala Phe Gly Lys Gly
                  90                  95                 100

 cta tct aat tgg aga cct tca ggc agc agt ggt cct ggc cag gca ggc      930
 Leu Ser Asn Trp Arg Pro Ser Gly Ser Ser Gly Pro Gly Gln Ala Gly
             105                 110                 115

 cag cca gga gct ggg acg atc ctt gca gga acc tca gga tta cag cag      978
 Gln Pro Gly Ala Gly Thr Ile Leu Ala Gly Thr Ser Gly Leu Gln Gln
         120                 125                 130

 gtg cag atg gca gga gct cca agc cag cag cag cca atg ctc agt ggg     1026
 Val Gln Met Ala Gly Ala Pro Ser Gln Gln Gln Pro Met Leu Ser Gly
     135                 140                 145

 gta caa atg gct cag gca ggt caa cca ggg aaa atg cca agt gga ata     1074
 Val Gln Met Ala Gln Ala Gly Gln Pro Gly Lys Met Pro Ser Gly Ile
 150                 155                 160                 165

 aaa acc aac atc aag tcg gct tcc atg cat ccc tac cag cgg ccc tcc     1122
 Lys Thr Asn Ile Lys Ser Ala Ser Met His Pro Tyr Gln Arg Pro Ser
                 170                 175                 180

 tgc ctg ggt ttc att ctg gct atc cct cta agg cgc aag gtg aag aag     1170
 Cys Leu Gly Phe Ile Leu Ala Ile Pro Leu Arg Arg Lys Val Lys Lys
             185                 190                 195

 ctt ctg ggc cag gaa gga aaa aaa aat gcc cac ctg cag ctc tgg tga     1218
 Leu Leu Gly Gln Glu Gly Lys Lys Asn Ala His Leu Gln Leu Trp 
         200                 205                 210

 agcttgggcc tgctctcctt tccatcctct aaggagccaa cttggctttt acctgtcaaa   1278

 tagtcataaa gtcccctatc ctttacccca ccttatacac acgaggcttt ctcaggaagt   1338

 ggctctgcca ggcaggacta tgtgggaaag ggtttttcct tagcacacga aaaagcccct   1398

 tcccctggat tcatgtttct tattttggag ggagaaggga attgcacttc acactgccat   1458

 cagggtttag ttgacctcat aatggtgccc actttctcga ctttggccag gatttccttc   1518

 aaagaaaacg actttccttc atttccctaa gcctgtggcc caaatggtgg accagaatga   1578

 tggtgggagg gggcaacccc cagtagcttt gcctgctttt ataaagttga acaaattgaa   1638

 tttagacatt caggctaacc tgcctttctt agtactcctt tgttggcatg ggcaggggtt   1698

 gagtcagcag aagtggacca aaggattcct ctgaataaag ttatttaaat tgaaaaaaaa   1758

 aaaa                                                                1762




      <210> 88
      <211> 958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(915)

      <400> 88
 cgacaggctg acgggaacgt ttacggtcag cgtgtgtcag cgacgtgcaa cccggaaggg     60

 aagaaggggc gtgtcaggct gcgcaggcgg ccagtccatt ggctggaaga gaccggagcc    120

 gggctccggg cccgaccaga ggagggcggt gctgcagggc tggtccggga ggtgacgacc    180

 ggcttcggag agtctatc  atg gca gct cgg act ggt cat acg gcc ttg aga     231
                      Met Ala Ala Arg Thr Gly His Thr Ala Leu Arg
                        1               5                  10

 agg gta gtc tcg gga tgc cgt ccg aag tcg gcg aca gcg gcc ggg gcg      279
 Arg Val Val Ser Gly Cys Arg Pro Lys Ser Ala Thr Ala Ala Gly Ala
              15                  20                  25

 cag gcg ccc gtg cgg aat ggc aga tat tta gct tcc tgt ggt ata ctg      327
 Gln Ala Pro Val Arg Asn Gly Arg Tyr Leu Ala Ser Cys Gly Ile Leu
          30                  35                  40

 atg agc aga act ctt cca cta cat acc tca att ttg cct aag gag ata      375
 Met Ser Arg Thr Leu Pro Leu His Thr Ser Ile Leu Pro Lys Glu Ile
      45                  50                  55

 tgt gca cga act ttc ttc aaa atc act gca cca tta ata aac aaa agg      423
 Cys Ala Arg Thr Phe Phe Lys Ile Thr Ala Pro Leu Ile Asn Lys Arg
  60                  65                  70                  75

 aaa gaa tat tca gag aga aga att tta gga tat tca atg cag gaa atg      471
 Lys Glu Tyr Ser Glu Arg Arg Ile Leu Gly Tyr Ser Met Gln Glu Met
                  80                  85                  90

 tat gat gta gta tcg gga gtg gag gat tac aag cat ttt gtt cct tgg      519
 Tyr Asp Val Val Ser Gly Val Glu Asp Tyr Lys His Phe Val Pro Trp
              95                 100                 105

 tgc aaa aaa tca gat gtt ata tca aag aga tct gga tat tgt aaa aca      567
 Cys Lys Lys Ser Asp Val Ile Ser Lys Arg Ser Gly Tyr Cys Lys Thr
         110                 115                 120

 aga tta gaa att gga ttt cca cct gtg ttg gag cga tat aca tca gta      615
 Arg Leu Glu Ile Gly Phe Pro Pro Val Leu Glu Arg Tyr Thr Ser Val
     125                 130                 135

 gta acc ttg gtg aaa cct cat tta gta aag gca tct tgt act gat ggg      663
 Val Thr Leu Val Lys Pro His Leu Val Lys Ala Ser Cys Thr Asp Gly
 140                 145                 150                 155

 aga ctt ttc aat cat ttg gag act att tgg cgt ttt agc cca ggt ctt      711
 Arg Leu Phe Asn His Leu Glu Thr Ile Trp Arg Phe Ser Pro Gly Leu
                 160                 165                 170

 cct ggc tac cca aga act tgt acc ttg gat ttt tca att tct ttt gaa      759
 Pro Gly Tyr Pro Arg Thr Cys Thr Leu Asp Phe Ser Ile Ser Phe Glu
             175                 180                 185

 ttt cga tca ctt cta cat tcc cag ctt gcc aca ctc ttt ttt gat gaa      807
 Phe Arg Ser Leu Leu His Ser Gln Leu Ala Thr Leu Phe Phe Asp Glu
         190                 195                 200

 gtt gtg aag cag atg gta gct gcc ttt gaa aga aga gca tgt aag ctg      855
 Val Val Lys Gln Met Val Ala Ala Phe Glu Arg Arg Ala Cys Lys Leu
     205                 210                 215

 tat ggt cca gaa aca aat ata cct cgg gag tta atg ctt cat gaa gtc      903
 Tyr Gly Pro Glu Thr Asn Ile Pro Arg Glu Leu Met Leu His Glu Val
 220                 225                 230                 235

 cat cac aca taa agg caaaaaagaa ctggtgccac ctgcttctga ctttagtttg      958
 His His Thr 






      <210> 89
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(245)

      <400> 89
 agaccgtaaa acactggcac accacatagg gcacttgtgg tgggcagcag   atg aaa      56
                                                          Met Lys
                                                            1

 aca att tca gtc gtt gga ata gag ctg tgc ccc cct gga aaa cgg ttc      104
 Thr Ile Ser Val Val Gly Ile Glu Leu Cys Pro Pro Gly Lys Arg Phe
           5                  10                  15

 atg att acg atg gtg gcg agc ttc gtg gcc atg gcg ggc cag ttc ctc      152
 Met Ile Thr Met Val Ala Ser Phe Val Ala Met Ala Gly Gln Phe Leu
      20                  25                  30

 atg cct ggg cta gcc gcc ctg tgc cgg gat tgg cag gtg ctg cag gcc      200
 Met Pro Gly Leu Ala Ala Leu Cys Arg Asp Trp Gln Val Leu Gln Ala
  35                  40                  45                  50

 ctc atc atc tgc ccc ttc ctg ctc atg ctg ctc tac tgg tcg tga gta      248
 Leu Ile Ile Cys Pro Phe Leu Leu Met Leu Leu Tyr Trp Ser 
                  55                  60

 cactctgcac agcgccctgg gctggtgcga ctgcacatgc ttcctgaagg cccggccccg    308

 ggcaggacac acaatcccca cacttcccac tagttgcagc ttgtggttct gtctgagaag    368

 gttttcctct ctttttaaaa aattttattg tttaaacttt ctgtcttgga aaactgttca    428

 aatatacaca aaaatagaag agtggaatga gcccatcacc cagctccaaa aatctgcaaa    488

 tgcactggcc agtctggctc accccttctt gctacccacc ccacggggtt attctgacat    548

 gaatttttat gaatggattg cagggaggtg gaggtcttgt gttaggaggg gggatttgga    608

 gatattaaag gagtgattta caaaagtccc cctatctctt ctaggcgagg ggtgggcaac    668

 cttcagcctg tgggccacat caggcccact gtctgttttt gtaaataaag ttttattgga    728

 acacaaaaaa aaaaaa                                                    744




      <210> 90
      <211> 6355
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(2018)

      <400> 90
 ctcactgtcc ctctccggct ctagctctct ccatataaac cctcaagatt atgtcaattg     60

 gttagagcca gccgggaatt tcgtgcgggt gctgaaggag ctgcgggagc cggagaaga     119                                                                 
 atg aaa ctg cgt gga gtc agc ctg gct gcc ggc ttg ttc tta ctg gcc      167
 Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala
   1               5                  10                  15

 ctg agt ctt tgg ggg cag cct gca gag gct gcg gct tgc tat ggg tgt      215
 Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys
              20                  25                  30

 tct cca gga tca aag tgt gac tgc agt ggc ata aaa ggg gaa aag gga      263
 Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly
          35                  40                  45

 gag aga ggg ttt cca ggt ttg gaa gga cac cca gga ttg cct gga ttt      311
 Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe
      50                  55                  60

 cca ggt cca gaa ggg cct ccg ggg cct cgg gga caa aag ggt gat gat      359
 Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp
  65                  70                  75                  80

 gga att cca ggg cca cca gga cca aaa gga atc aga ggt cct cct gga      407
 Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly
                  85                  90                  95

 ctt cct gga ttt cca ggg aca cca ggt ctt cct gga atg cca ggc cac      455
 Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His
             100                 105                 110

 gat ggg gcc cca gga cct caa ggt att ccc gga tgc aat gga acc aag      503
 Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys
         115                 120                 125

 gga gaa cgt gga ttt cca ggc agt ccc ggt ttt cct ggt tta cag ggt      551
 Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly
     130                 135                 140

 cct cca gga ccc cct ggg atc cca ggt atg aag ggt gaa cca ggt agt      599
 Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser
 145                 150                 155                 160

 ata att atg tca tca ctg cca gga cca aag ggt aat cca gga tat cca      647
 Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro
                 165                 170                 175

 ggt cct cct gga ata caa ggc cta cct ggt ccc act ggt ata cca ggg      695
 Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly
             180                 185                 190

 cca att ggt ccc cca gga cca cca ggt ttg atg ggc cct cct ggt cca      743
 Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro
         195                 200                 205

 cca gga ctt cca gga cct aag ggg aat atg ggc tta aat ttc cag gga      791
 Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly
     210                 215                 220

 ccc aaa ggt gaa aaa ggt gag caa ggt ctt cag ggc cca cct ggg cca      839
 Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro
 225                 230                 235                 240

 cct ggg cag atc agt gaa cag aaa aga cca att gat gta gag ttt cag      887
 Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln
                 245                 250                 255

 aaa gga gat cag gga ctt cct ggt gac cga ggg cct cct gga cct cca      935
 Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro
             260                 265                 270

 ggg ata cgt ggt cct cca ggt ccc cca ggt ggt gag aaa ggt gag aag      983
 Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys
         275                 280                 285

 ggt gag caa gga gag cca ggc aaa aga ggt aaa cca ggc aaa gat gga     1031
 Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly
     290                 295                 300

 gaa aat ggc caa cca gga att cct ggt ttg cct ggt gat cct ggt tac     1079
 Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr
 305                 310                 315                 320

 cct ggt gaa ccc gga agg gat ggt gaa aag ggc caa aaa ggt gac act     1127
 Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr
                 325                 330                 335

 ggc cca cct gga cct cct gga ctt gta att cct aga cct ggg act ggt     1175
 Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly
             340                 345                 350

 ata act ata gga gaa aaa gga aac att ggg ttg cct ggg ttg cct gga     1223
 Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly
         355                 360                 365

 gaa aaa gga gag cga gga ttt cct gga ata cag ggt cca cct ggc ctt     1271
 Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu
     370                 375                 380

 cct gga cct cca ggg gct gca gtt atg ggt cct cct ggc cct cct gga     1319
 Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly
 385                 390                 395                 400

 ttt cct gga gaa agg ggt cag aaa ggt gat gaa gga cca cct gga att     1367
 Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile
                 405                 410                 415

 tcc att cct gga cct cct gga ctt gac gga cag cct ggg gct cct ggg     1415
 Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly
             420                 425                 430

 ctt cca ggg cct cct ggc cct gct ggc cct cac att cct cct agt gat     1463
 Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp
         435                 440                 445

 gag ata tgt gaa cca ggc cct cca ggc ccc cca gga tct cca ggt gat     1511
 Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp
     450                 455                 460

 aaa gga ctc caa gga gaa caa gga gtg aaa ggt gac aaa ggt gac act     1559
 Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr
 465                 470                 475                 480

 tgc ttc aac tgc att gga act ggt att tca ggg cct cca ggt caa cct     1607
 Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro
                 485                 490                 495

 ggt ttg cca ggt ctc cca ggt cct cca gga tct ctt ggt ttc cct gga     1655
 Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly
             500                 505                 510

 cag aaa ggg gaa aaa gga caa gct ggt gca act ggt ccc aaa gga tta     1703
 Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu
         515                 520                 525

 cca ggc att cca gga gct cca ggt gct cca ggc ttt cct gga tct aaa     1751
 Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys
     530                 535                 540

 ggt gaa cct ggt gat atc ctc act ttt cca gga atg aag ggt gac aaa     1799
 Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys
 545                 550                 555                 560

 gga gag ttg ggt tcc cct gga gct cca ggg ctt cct ggt tta cct ggc     1847
 Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly
                 565                 570                 575

 act cct gga cag gat gga ttg cca ggg ctt cct ggc ccg aaa gga gag     1895
 Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu
             580                 585                 590

 cct ggt gga att act ttt aag ggt gaa aga ggt ccc cct ggg aac cca     1943
 Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro
         595                 600                 605

 ggt tta cca ggc ctc cca ggg aat ata ggg cct atg ggt ccc cct ggt     1991
 Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly
     610                 615                 620

 ttc ggc cct cca ggg ccc agt agg tga aaaag gcatacaagg tgtggcagga     2043
 Phe Gly Pro Pro Gly Pro Ser Arg 
 625                 630

 aatccaggcc agccaggaat accaggtcct aaaggggatc caggtcagac tataacccag   2103

 ccggggaagc ctggcttgcc tggtaaccca ggcagagatg gtgatgtagg tcttccaggt   2163

 gaccctggac ttccagggca accaggcttg ccagggatac ctggtagcaa aggagaacca   2223

 ggtatccctg gaattgggct tcctggacca cctggtccca aaggctttcc tggaattcca   2283

 ggacctccag gagcacctgg gacacctgga agaattggtc tagaaggccc tcctgggcca   2343

 cccggctttc caggaccaaa gggtgaacca ggatttgcat tacctgggcc acctgggcca   2403

 ccaggacttc caggtttcaa aggagcactt ggtccaaaag gtgatcgtgg tttcccagga   2463

 cctccgggtc ctccaggacg cactggctta gatgggctcc ctggaccaaa aggtgatgtt   2523

 ggaccaaatg gacaacctgg accaatggga cctcctgggc tgccaggaat aggtgttcag   2583

 ggaccaccag gaccaccagg gattcctggg ccaataggtc aacctggttt acatggaata   2643

 ccaggagaga agggggatcc aggacctcct ggacttgatg ttccaggacc cccaggtgaa   2703

 agaggcagtc cagggatccc cggagcacct ggtcctatag gacctccagg atcaccaggg   2763

 cttccaggaa aagcaggtgc ctctggattt ccaggtacca aaggtgaaat gggtatgatg   2823

 ggacctccag gcccaccagg acctttggga attcctggca ggagtggtgt acctggtctt   2883

 aaaggtgatg atggcttgca gggtcagcca ggacttcctg gccctacagg agaaaaaggt   2943

 agtaaaggag agcctggcct tccaggccct cctggaccaa tggatccaaa tcttctgggc   3003

 tcaaaaggag agaaggggga acctggctta ccaggtatac ctggagtttc agggccaaaa   3063

 ggttatcagg gtttgcctgg agacccaggg caacctggac tgagtggaca acctggatta   3123

 ccaggaccac caggtcccaa aggtaaccct ggtctccctg gacagccagg tcttatagga   3183

 cctcctggac ttaaaggaac catcggtgat atgggttttc cagggcctca gggtgtggaa   3243

 gggcctcctg gaccttctgg agttcctgga caacctggct ccccaggatt acctggacag   3303

 aaaggcgaca aaggtgatcc tggtatttca agcattggtc ttccaggtct tcctggtcca   3363

 aagggtgagc ctggtctgcc tggataccca gggaaccctg gtatcaaagg ttctgtggga   3423

 gatcctggtt tgcccggatt accaggaacc cctggagcaa aaggacaacc aggccttcct   3483

 ggattcccag gaaccccagg ccctcctgga ccaaaaggta ttagtggccc tcctgggaac   3543

 cccggccttc caggagaacc tggtcctgta ggtggtggag gtcatcctgg gcaaccaggg   3603

 cctccaggcg aaaaaggcaa acccggtcaa gatggtattc ctggaccagc tggacagaag   3663

 ggtgaaccag gtcaaccagg ctttggaaac ccaggacccc ctggacttcc aggactttct   3723

 ggccaaaagg gtgatggagg attacctggg attccaggaa atcctggcct tccaggtcca   3783

 aagggcgaac caggctttca cggtttccct ggtgtgcagg gtcccccagg ccctcctggt   3843

 tctccgggtc cagctctgga aggacctaaa ggcaaccctg ggccccaagg tcctcctggg   3903

 agaccaggtc taccaggtcc agaaggtcct ccaggtctcc ctggaaatgg aggtattaaa   3963

 ggagagaagg gaaatccagg ccaacctggg ctacctggct tgcctggttt gaaaggagat   4023

 caaggaccac caggactcca gggtaatcct ggccggccgg gtctcaatgg aatgaaagga   4083

 gatcctggtc tccctggtgt tccaggattc ccaggcatga aaggacccag tggagtacct   4143

 ggatcagctg gccctgaggg ggaaccggga cttattggtc ctccaggtcc tcctggatta   4203

 cctggtcctt caggacagag tatcataatt aaaggagatg ctggtcctcc aggaatccct   4263

 ggccagcctg ggctaaaggg tctaccagga ccccaaggac ctcaaggctt accaggtcca   4323

 actggccctc caggagatcc tggacgcaat ggactccctg gctttgatgg tgcaggaggg   4383

 cgcaaaggag acccaggtct gccaggacag ccaggtaccc gtggtttgga tggtccccct   4443

 ggtttggatg gattgcaagg tcccccaggt ccccctggaa cctcctctgt tgcacatgga   4503

 tttcttatta cacgccacag ccagacaacg gatgcaccac aatgcccaca gggaacactt   4563

 caggtctatg aaggcttttc tctcctgtat gtacaaggaa ataaaagagc ccacggtcaa   4623

 gacttgggga cggctggcag ctgccttcgt cgctttagta ccatgccttt catgttctgc   4683

 aacatcaata atgtttgcaa ctttgcttca agaaatgact attcttactg gctctctacc   4743

 ccagagccca tgccaatgag catgcaaccc ctaaagggcc agagcatcca gccattcatt   4803

 agtcgatgtg cagtatgtga agctccagct gtggtgatcg cagttcacag tcagacgatc   4863

 cagattcccc attgtcctca gggatgggat tctctgtgga ttggttattc cttcatgatg   4923

 catacaagtg caggggcaga aggctcaggt caagccctag cctcccctgg ttcctgcttg   4983

 gaagagtttc gttcagctcc cttcatcgaa tgtcatggga ggggtacctg taactactat   5043

 gccaactcct acagcttttg gctggcaact gtagatgtgt cagacatgtt cagtaaacct   5103

 cagtcagaaa cgctgaaagc aggagacttg aggacacgaa ttagccgatg tcaagtgtgc   5163

 atgaagagga cataacattt tgaagaattc cttttgtgtt ttaaaatgtg atatatatat   5223

 atataaaatt cctaggatgc agtgtctcat tgtccccaac tttactactg ctgccgtcaa   5283

 tggtgctact atatatgatc aagataacat gctgactagt aaccatgaag attcagatgt   5343

 acctcagcaa tgcgccagag caaagtctct attatttttc tactaaagaa ataaggaagt   5403

 gaatttactt tttgggtcca gaatgacttt ctccaagaat tataagatga aaattatata   5463

 ttttgcccag ttactaaaat ggtacattaa aaattcaatt aagagaagag tcacattgag   5523

 taaaataaaa gactgcagtt tgtgggaaga attatttttc acggtgctac taatcctgct   5583

 gtatcccggg tttttaatat aaaggtgtta agcttatttt gctttgtaag taaagaatgt   5643

 gtatattgtg aacagccttt tagctcaaaa tgttgagtca tttacatatg acatagcatg   5703

 aatcactctt tacagaaaat gtaggaaacc ctagaataca gacagcaata ttttatattc   5763

 atgtttatca aagtgagagg acttatattc ctacatcaag ttactactga gagtaaattt   5823

 attttgagtt ttatcccgta agttctgttt tgattttttt taaaaaacaa acccttttag   5883

 tcactttaat cagaatttta aatgttcatg ttacatacca aattataata tctaatggag   5943

 caatttgtct tttgctatat tctccaagat tatctcttaa gaccatatgc cccctgtttt   6003

 aatgtttctt acatcttgtt tttactcatt tctgactgga caaagttctt ccaaacaatt   6063

 ctgagaaaca aaaacacaca cgcagaatta acaattcttt tccctgtgct tcttatgtaa   6123

 gaatcctcct gtggcctctg cttgtacaga actgggaaac aacacttggt tagtctcttt   6183

 taagttacaa aaagccaatt gatgtttctt attcttttta aattttaaat attttgttat   6243

 aaatactcac aggatacctt atttccctag ctatcatctc ctgacttaat gttttttaaa   6303

 cccaccaata taaatttaat taaagatata tgttgtaagg aaaaaaaaaa aa           6355




      <210> 91
      <211> 2382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (440)..(1063)

      <400> 91
 ggcagcctcg cccgtcgcgg agagtgggct ctgcccgccg tcccccgggg gctgcttccc     60

 gccccaggcc tccgcggagg acacgtgtca gcacgttccc gcggttgtca ttccattgtc    120

 atagcccttc ccctaggccg ggaacccctc ccccccacca gccccagttc ttttatccct    180

 gggcccaacc tccccgccga cccgcggtcc aggcctcggt ctctctcttc ggcggcgagc    240

 cgcggcccag accccggcag aggacacttg tcggcacgtt ctcacccctg tcatctcagc    300

 cccctgccta gctccacccc aggcttggga acccggcccc tgacggccca ttgtccgcgg    360

 gcccagcccc cgcgctgaac gcacgctcgc ccttgcccct aaccagcgcg tctaccccgg    420

 caacgcgcag tgacctggg atg cag ccc tca ggc tgg gcg gcc gcc agg gag     472
                      Met Gln Pro Ser Gly Trp Ala Ala Ala Arg Glu
                        1               5                  10

 gcg gcg ggc cgc gac atg ctg gcc gcc gac ctc cgg tgc agc ctc ttc      520
 Ala Ala Gly Arg Asp Met Leu Ala Ala Asp Leu Arg Cys Ser Leu Phe
              15                  20                  25

 gcc tcg gcc ctg cag agc tac aag cgc gac tcg gtg ctg cgg ccc ttc      568
 Ala Ser Ala Leu Gln Ser Tyr Lys Arg Asp Ser Val Leu Arg Pro Phe
          30                  35                  40

 ccc gcg tcc tac gcc cgc ggc gac tgt aag gac ttt gaa gcc ctg aca      616
 Pro Ala Ser Tyr Ala Arg Gly Asp Cys Lys Asp Phe Glu Ala Leu Thr
      45                  50                  55

 tcc ttg ttc gga gag ggg acc tac ctc acc agt gac ttg agc ctg gcc      664
 Ser Leu Phe Gly Glu Gly Thr Tyr Leu Thr Ser Asp Leu Ser Leu Ala
  60                  65                  70                  75

 ctc ata tac agc ccc cat ggc cat ggg tgg cag cac agc ctc ctc ggc      712
 Leu Ile Tyr Ser Pro His Gly His Gly Trp Gln His Ser Leu Leu Gly
                  80                  85                  90

 ccc atc ctt agc tgt gtg gcc gtg tgt gag gtc att gac cat ccg gac      760
 Pro Ile Leu Ser Cys Val Ala Val Cys Glu Val Ile Asp His Pro Asp
              95                 100                 105

 gtc aag tgc caa acc aag aag aag gat tcc aag gag ata gat cgc aga      808
 Val Lys Cys Gln Thr Lys Lys Lys Asp Ser Lys Glu Ile Asp Arg Arg
         110                 115                 120

 cga gcg aga atc aaa cat agt gaa ggg gga gac atc cct ccc aag tac      856
 Arg Ala Arg Ile Lys His Ser Glu Gly Gly Asp Ile Pro Pro Lys Tyr
     125                 130                 135

 ttc gtg gtc acc aat aac cag ctg ctg cga gtg aag tac ctc ctg gtg      904
 Phe Val Val Thr Asn Asn Gln Leu Leu Arg Val Lys Tyr Leu Leu Val
 140                 145                 150                 155

 tat tca cag aag cca ccc aag agg gct tcg agc cag ctc tcc tgg ttt      952
 Tyr Ser Gln Lys Pro Pro Lys Arg Ala Ser Ser Gln Leu Ser Trp Phe
                 160                 165                 170

 tcc agc cat tgg ttt acc gtc atg ata tcc ctg tat ctg ctg ctg ctg     1000
 Ser Ser His Trp Phe Thr Val Met Ile Ser Leu Tyr Leu Leu Leu Leu
             175                 180                 185

 ctc ata gtg agt gtc atc aac tcc tct gct ttc caa cac ttt tgg aat     1048
 Leu Ile Val Ser Val Ile Asn Ser Ser Ala Phe Gln His Phe Trp Asn
         190                 195                 200

 cgt gcg aaa aga taa tctttctggg cctggtgtgg gggctacctc aactatgtgc     1103
 Arg Ala Lys Arg 
     205

 cttatggtaa cttgttctgt acctcctatg cctcatgtcc agccaggttg agcctagggg   1163

 ccagttgggg gaccacagga caattttcat atggcctaaa tgtatccatt gcctttgatg   1223

 atgttcccag ccatactcca gtcaacgggg actactagtc cctcactctt aggttttagg   1283

 ggagtccttc catctgctcc ttcttaaact gtcctaggga gttggctttt cagccagggc   1343

 caaaggaaaa agccctgctg catttaaaaa caaagtgtcc aagctgtcag tggtgtgttt   1403

 acaatctctc ctggcagagg ttggcccttt ctctaatgcc ttctggaagg cggaaaatgt   1463

 gggaactata aatcactagg cggttgcctt gttttgactt gagacaccca agaggaacag   1523

 tcatgtttct cataaaaatc agtgggatca tttttgaatt ccatcagcct ttgtatgtga   1583

 gtgcaaaaca ttttaacagt tttctcaaat caacaaacag ccttctccta tagctgtact   1643

 tgcccccctc cccaaaaaac catggatgag aaagaaagga gtcaggggcc tgataaaaaa   1703

 tacagactta atgagcaact caagatgaga aaactgctct ttttccaaaa attaccaact   1763

 gctgattaca gctgaaatgg aaccaaatgt ttgttttctg attttttttt aatagctgtt   1823

 taacaaatta gtctttgctg agtaaaaggg gaaatttcta aacctagtgc actgtttggc   1883

 cagtgtccac agcctctttt ctggctgtgt tttagagaaa gggatttgag ctataggctc   1943

 gcctcctgtt ctcattctca caaagctgcc ttgactgtgg cctgcaacca cgagtgccat   2003

 gctttcaggt cttctgtggc ctactggcct tcaagacaga ggcctgcccc agtgtgccac   2063

 agatccatgt ggatggagcc tccttcagag gggtcacagg tctttgagac tcagcctggg   2123

 ctttaatgtg taggaaaagc cttctggcca cccagagagc cggagccctg cttgctgtat   2183

 tctctgctcc cttcttcctg ctgggtttta gccataatag ggcccggtac gatttgggag   2243

 tgacatttct gtaaagaaga ggaaaaatca tttttctata atttgtaaag ttgtgaaaga   2303

 gccactacca cagtttttac attgattatt ggaacatttc agaataaata aagatatttt   2363

 tttaatgaaa aaaaaaaaa                                                2382




      <210> 92
      <211> 2589
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (440)..(1270)

      <400> 92
 ggcagcctcg cccgtcgcgg agagtgggct ctgcccgccg tcccccgggg gctgcttccc     60

 gccccaggcc tccgcggagg acacgtgtca gcacgttccc gcggttgtca ttccattgtc    120

 atagcccttc ccctaggccg ggaacccctc ccccccacca gccccagttc ttttatccct    180

 gggcccaacc tccccgccga cccgcggtcc aggcctcggt ctctctcttc ggcggcgagc    240

 cgcggcccag accccggcag aggacacttg tcggcacgtt ctcacccctg tcatctcagc    300

 cccctgccta gctccacccc aggcttggga acccggcccc tgacggccca ttgtccgcgg    360

 gcccagcccc cgcgctgaac gcacgctcgc ccttgcccct aaccagcgcg tctaccccgg    420

 caacgcgcag tgacctggg atg cag ccc tca ggc tgg gcg gcc gcc agg gag     472
                      Met Gln Pro Ser Gly Trp Ala Ala Ala Arg Glu
                        1               5                  10

 gcg gcg ggc cgc gac atg ctg gcc gcc gac ctc cgg tgc agc ctc ttc      520
 Ala Ala Gly Arg Asp Met Leu Ala Ala Asp Leu Arg Cys Ser Leu Phe
              15                  20                  25

 gcc tcg gcc ctg cag agc tac aag cgc gac tcg gtg ctg cgg ccc ttc      568
 Ala Ser Ala Leu Gln Ser Tyr Lys Arg Asp Ser Val Leu Arg Pro Phe
          30                  35                  40

 ccc gcg tcc tac gcc cgc ggc gac tgt aag gac ttt gaa gcc ctg ttt      616
 Pro Ala Ser Tyr Ala Arg Gly Asp Cys Lys Asp Phe Glu Ala Leu Phe
      45                  50                  55

 gaa aag atc caa aag ctg act ggg gct cct cac acg cct gtt cct gca      664
 Glu Lys Ile Gln Lys Leu Thr Gly Ala Pro His Thr Pro Val Pro Ala
  60                  65                  70                  75

 ccg gac ttc ctg ttt gaa att gag tac ttt gac cca gcc aac gcc aaa      712
 Pro Asp Phe Leu Phe Glu Ile Glu Tyr Phe Asp Pro Ala Asn Ala Lys
                  80                  85                  90

 ttt tat gag acc aaa gga gaa cga gac cta atc tat gca ttt cat ggt      760
 Phe Tyr Glu Thr Lys Gly Glu Arg Asp Leu Ile Tyr Ala Phe His Gly
              95                 100                 105

 agc cgc cta gaa aac ttc cat tcc att atc cac aat ggc ctg cac tgc      808
 Ser Arg Leu Glu Asn Phe His Ser Ile Ile His Asn Gly Leu His Cys
         110                 115                 120

 cat ctg aac aag aca tcc ttg ttc gga gag ggg acc tac ctc acc agt      856
 His Leu Asn Lys Thr Ser Leu Phe Gly Glu Gly Thr Tyr Leu Thr Ser
     125                 130                 135

 gac ttg agc ctg gcc ctc ata tac agc ccc cat ggc cat ggg tgg cag      904
 Asp Leu Ser Leu Ala Leu Ile Tyr Ser Pro His Gly His Gly Trp Gln
 140                 145                 150                 155

 cac agc ctc ctc ggc ccc atc ctt agc tgt gtg gcc gtg tgt gag gtc      952
 His Ser Leu Leu Gly Pro Ile Leu Ser Cys Val Ala Val Cys Glu Val
                 160                 165                 170

 att gac cat ccg gac gtc aag tgc caa acc aag aag aag gat tcc aag     1000
 Ile Asp His Pro Asp Val Lys Cys Gln Thr Lys Lys Lys Asp Ser Lys
             175                 180                 185

 gag ata gat cgc aga cga gcg aga atc aaa cat agt gaa ggg gga gac     1048
 Glu Ile Asp Arg Arg Arg Ala Arg Ile Lys His Ser Glu Gly Gly Asp
         190                 195                 200

 atc cct ccc aag tac ttc gtg gtc acc aat aac cag ctg ctg cga gtg     1096
 Ile Pro Pro Lys Tyr Phe Val Val Thr Asn Asn Gln Leu Leu Arg Val
     205                 210                 215

 aag tac ctc ctg gtg tat tca cag aag cca ccc aag agg gct tcg agc     1144
 Lys Tyr Leu Leu Val Tyr Ser Gln Lys Pro Pro Lys Arg Ala Ser Ser
 220                 225                 230                 235

 cag ctc tcc tgg ttt tcc agc cat tgg ttt acc gtc atg ata tcc ctg     1192
 Gln Leu Ser Trp Phe Ser Ser His Trp Phe Thr Val Met Ile Ser Leu
                 240                 245                 250

 tat ctg ctg ctg ctg ctc ata gtg agt gtc atc aac tcc tct gct ttc     1240
 Tyr Leu Leu Leu Leu Leu Ile Val Ser Val Ile Asn Ser Ser Ala Phe
             255                 260                 265

 caa cac ttt tgg aat cgt gcg aaa aga taa t ctttctgggc ctggtgtggg     1291
 Gln His Phe Trp Asn Arg Ala Lys Arg 
         270                 275

 ggctacctca actatgtgcc ttatggtaac ttgttctgta cctcctatgc ctcatgtcca   1351

 gccaggttga gcctaggggc cagttggggg accacaggac aattttcata tggcctaaat   1411

 gtatccattg cctttgatga tgttcccagc catactccag tcaacgggga ctactagtcc   1471

 ctcactctta ggttttaggg gagtccttcc atctgctcct tcttaaactg tcctagggag   1531

 ttggcttttc agccagggcc aaaggaaaaa gccctgctgc atttaaaaac aaagtgtcca   1591

 agctgtcagt ggtgtgttta caatctctcc tggcagaggt tggccctttc tctaatgcct   1651

 tctggaaggc ggaaaatgtg ggaactataa atcactaggc ggttgccttg ttttgacttg   1711

 agacacccaa gaggaacagt catgtttctc ataaaaatca gtgggatcat ttttgaattc   1771

 catcagcctt tgtatgtgag tgcaaaacat tttaacagtt ttctcaaatc aacaaacagc   1831

 cttctcctat agctgtactt gcccccctcc ccaaaaaacc atggatgaga aagaaaggag   1891

 tcaggggcct gataaaaaat acagacttaa tgagcaactc aagatgagaa aactgctctt   1951

 tttccaaaaa ttaccaactg ctgattacag ctgaaatgga accaaatgtt tgttttctga   2011

 ttttttttta atagctgttt aacaaattag tctttgctga gtaaaagggg aaatttctaa   2071

 acctagtgca ctgtttggcc agtgtccaca gcctcttttc tggctgtgtt ttagagaaag   2131

 ggatttgagc tataggctcg cctcctgttc tcattctcac aaagctgcct tgactgtggc   2191

 ctgcaaccac gagtgccatg ctttcaggtc ttctgtggcc tactggcctt caagacagag   2251

 gcctgcccca gtgtgccaca gatccatgtg gatggagcct ccttcagagg ggtcacaggt   2311

 ctttgagact cagcctgggc tttaatgtgt aggaaaagcc ttctggccac ccagagagcc   2371

 ggagccctgc ttgctgtatt ctctgctccc ttcttcctgc tgggttttag ccataatagg   2431

 gcccggtacg atttgggagt gacatttctg taaagaagag gaaaaatcat ttttctataa   2491

 tttgtaaagt tgtgaaagag ccactaccac agtttttaca ttgattattg gaacatttca   2551

 gaataaataa agatattttt ttaatgaaaa aaaaaaaa                           2589




      <210> 93
      <211> 3619
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(2492)

      <400> 93
 gcacgagctt cgggccctcc cctgcatccc agccggggcc tctccgagcc ggcgctgatc     60

 gatgccgaca caccccgggg accctatcgc gactccatcg cgccatatcg cgacaccatc    120

 gtgccctgtc gagactccat tttgtcacag cccttttcaa tatatatctt ttttttttta    180

 atttgccctg tcatctttgg gggctgtctc ccatgtcgtg attttgacgt gatctctccg    240

 tgacatcacc gcgccatcgt gaagtgtgat ctcatcgccg ccctgtcgtg acttcatca     299                                                                 
 atg tcg tgt tgt gac ctg gct gcg gcg gga cag gtg ttg ggc aag gcg      347
 Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Val Leu Gly Lys Ala
   1               5                  10                  15

 agc atc atg gcc tcg gat tgc gag cca gct ctg aac cag gca gag ggc      395
 Ser Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly
              20                  25                  30

 cga aac ccc acc ctg gag cgc tac ctg gga gcc ctc cgt gag gcc aag      443
 Arg Asn Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys
          35                  40                  45

 aat gac agc gag cag ttt gca gcc ctg ctg cta gtg acc aag gca gtc      491
 Asn Asp Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val
      50                  55                  60

 aaa gca ggt gac ata gat gcc aaa act cgg cgg cgg atc ttc gat gct      539
 Lys Ala Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala
  65                  70                  75                  80

 gtc ggc ttc acc ttc ccc aat cgt ctc ctg acc acc aag gag gcg ccg      587
 Val Gly Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro
                  85                  90                  95

 gat ggc tgc cct gac cat gtt ctg cgg gct ttg ggt gtg gcc ctg ctg      635
 Asp Gly Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu
             100                 105                 110

 gcc tgc ttc tgc agt gac cct gaa ctg gcc gcc cat ccc caa gtc ctg      683
 Ala Cys Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu
         115                 120                 125

 aac aag att ccc att ctt agc acc ttc ctc aca gcc cgg ggg gac ccg      731
 Asn Lys Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro
     130                 135                 140

 gac gat gct gcc cgc cgc tcc atg att gat gac acc tac cag tgc ctg      779
 Asp Asp Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu
 145                 150                 155                 160

 acg gct gta gca ggc aca ccc aga ggg cct cgg cac ctc att gct ggt      827
 Thr Ala Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly
                 165                 170                 175

 ggc acc gtg tct gcc cta tgc cag gca tac ctg ggg cac ggc tat ggc      875
 Gly Thr Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly
             180                 185                 190

 ttt gac cag gcc ctg gca ctc ctg gtg ggg ctg ctg gct gct gcc gag      923
 Phe Asp Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu
         195                 200                 205

 aca cag tgc tgg aag gag gcg gag ccc gac ctg ctg gcc gtg ttg cgg      971
 Thr Gln Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg
     210                 215                 220

 ggc ctc agt gag gat ttc cag aaa gct gag gat gcc agc aag ttt gag     1019
 Gly Leu Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu
 225                 230                 235                 240

 ctc tgc cag ctg ctg ccc ctc ttt ttg ccc ccg aca acc gtg ccc cct     1067
 Leu Cys Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro
                 245                 250                 255

 gaa tgc tac cgg gat ctg cag gcc ggg ctg gca cgc atc ctg gga agc     1115
 Glu Cys Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser
             260                 265                 270

 aag ctg agc tcc tgg cag cgc aac cct gca ctg aag ctg gca gcc cgc     1163
 Lys Leu Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg
         275                 280                 285

 ctg gca cac gcc tgc ggc tcc gac tgg atc ccg gcg ggc agc tcc ggg     1211
 Leu Ala His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly
     290                 295                 300

 agc aag ttc ctg gcc ctg ctg gtg aat ctg gcg tgc gtg gaa gtg cgg     1259
 Ser Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg
 305                 310                 315                 320

 ctg gca ctg gag gag acg ggc acg gag gtg aaa gag gat gtg gtg acc     1307
 Leu Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr
                 325                 330                 335

 gcc tgc tat gcc ctc atg gag ttg ggg atc cag gaa tgc act cgc tgt     1355
 Ala Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys
             340                 345                 350

 gag cag tca ctg ctt aag gag cca cag aag gtg cag ctc gtg agc gtc     1403
 Glu Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val
         355                 360                 365

 atg aag gag gcc ata ggg gct gtt atc cac tac ctg ctg cag gtg ggg     1451
 Met Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly
     370                 375                 380

 tca gag aag cag aag gag ccc ttt gtg ttt gcc tcg gtg cgg atc ctg     1499
 Ser Glu Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu
 385                 390                 395                 400

 ggt gcc tgg ctg gcc gag gag acc tca tcc ttg cgt aag gag gtg tgc     1547
 Gly Ala Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys
                 405                 410                 415

 cag ctg ctg ccc ttc ctc gtc cgc tat gcc aag acc ctc tac gag gag     1595
 Gln Leu Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu
             420                 425                 430

 gcc gag gag gcc aat gac ctt tcc cag cag gtg gcc aac ctg gcc atc     1643
 Ala Glu Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile
         435                 440                 445

 tcc ccc acc acc cca ggg ccc acc tgg cca gga gac gct ctc cgg ctc     1691
 Ser Pro Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu
     450                 455                 460

 ctc ctg cct ggc tgg tgc cac ctg acc gtt gaa gat ggg ccc cgg gag     1739
 Leu Leu Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu
 465                 470                 475                 480

 atc ctg atc aag gaa ggg gcc ccc tcg ctt ctg tgc aag tat ttc ctg     1787
 Ile Leu Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu
                 485                 490                 495

 cag cag tgg gaa ctc aca tcc cct ggc cac gac acc tcg gtg ctg cct     1835
 Gln Gln Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro
             500                 505                 510

 gac agc gtg gag att ggc ctg cag acc tgc tgc cac atc ttc ctc aac     1883
 Asp Ser Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn
         515                 520                 525

 ctc gtg gtc acc gca ccg ggg ctg atc aag cgt gac gcc tgc ttc aca     1931
 Leu Val Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr
     530                 535                 540

 tct cta atg aac acc ctc atg acg tcg cta cca gca cta gtg cag caa     1979
 Ser Leu Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln
 545                 550                 555                 560

 cag gga agg ctg ctt ctg gct gct aat gtg gcc acc ctg ggg ctc ctc     2027
 Gln Gly Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu
                 565                 570                 575

 atg gcc cgg ctc ctt agc acc tct cca gct ctt cag gga aca cca gca     2075
 Met Ala Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala
             580                 585                 590

 tcc cga ggg ttc ttc gca gct gcc atc ctc ttc cta tca cag tcc cac     2123
 Ser Arg Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His
         595                 600                 605

 gtg gcg cgg gcc acc ccg ggc tca gac cag gca gtg cta gcc ctg tcc     2171
 Val Ala Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser
     610                 615                 620

 cct gag tat gag ggc atc tgg gcc gac ctg cag gag ctc tgg ttc ctg     2219
 Pro Glu Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu
 625                 630                 635                 640

 ggc atg cag gcc ttc acc ggc tgt gtg cct ctg ctg ccc tgg ctg gcc     2267
 Gly Met Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala
                 645                 650                 655

 ccc gct gcc ctg cgc tcc cgc tgg ccg cag gag ctg ctc cag ctg cta     2315
 Pro Ala Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu
             660                 665                 670

 ggc agt gtc agc ccc aac tct gtc aag ccc gag atg gtg gcc gcc tat     2363
 Gly Ser Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr
         675                 680                 685

 cag ggt gtc ctg gtg gag ctg gcg cgg gcc aac cgg ctg tgc cgg gag     2411
 Gln Gly Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu
     690                 695                 700

 gcc atg agg ctg cag gcg ggc gag gag acg gcc agc cac tac cgc atg     2459
 Ala Met Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met
 705                 710                 715                 720

 gct gcc ttg gag cag tgc ctg tca gag ccc tga ggggtgtc caccggggac     2510
 Ala Ala Leu Glu Gln Cys Leu Ser Glu Pro 
                 725                 730

 agacccaggg gcgggcagag agggaaggag ggaggaggca tcttccctga agcccccaat   2570

 ctggcccccc cctccccaga cttcctcccc aaaacacccc agctttctgg cttttctgag   2630

 ggcaagggca tggtgcccac ccctcaagtg taaggaactg cgttccgccc ctcaggcccc   2690

 catgggggca gggatcggct tggaaatcaa cgtggttgtc cccgccaggc cggggaaggt   2750

 tggagcagcc cccagggagg ggggcactag gtgtcattgt gcccgatgtc tggctcccct   2810

 gcaggaggga ggctccaggg taagacaggg ctggcaggag cagactgcct cagcccatgt   2870

 gccctgccgg ccagggcgtg ggctcccctc ggctgtggtg cctcctctgg ccccccaggt   2930

 ccacgtcctt taaattggcc ctttggctct tgcccttggc tcccttgggc agacagcagg   2990

 cttaggccat tgatatcgca gttcttccta tcagcttcag tgacccaggg tctgaactgc   3050

 ctccatccta gggcaacctg gggcagacag gcctggtggg gggtggggaa acctccttcc   3110

 acctgagctt gcttgaaggg acccagagtc tttgggccca gatctttaaa cctttgtgtc   3170

 gtgttgcagc agagtgacga tgggggttgg ggggttattt attttgcctg tccttatccc   3230

 tgcttggaca cctgagcatc tgattcctgt ccccctggtg ccatctggcc tggctggagc   3290

 caggaacagg agggacactt ccccagaatc cgcatgtttc cccagtgatt acactccact   3350

 gccaccgtgg tgcctggctt taactcccac ccctgctatg actcctctct gcagagacgc   3410

 gactggcggc tccagcaggg actacctttc ttataaaccc agggggacca cacacacaca   3470

 cacacacaca cacacacaca cacacacaca cacacacaca cactcttgat cccttgcttc   3530

 cctcccccag tgcgttctgt gatcgccaag ttcaaagctg tgcacatgtg gacactcaat   3590

 aaatgttcat tggtgacaaa aaaaaaaaa                                     3619




      <210> 94
      <211> 2324
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(1146)

      <400> 94
 cgccgccgag gcttacccgg gaatgtctgg gcccgcgcct cgcggccccc aagctccacg     60

 ctgcgcccgc tgtcccggcc tctaaaggcc gccacgtccc tgcggcgcgc gcaggcagaa    120

 agcggcttcg tgccggcgga gggggcccgg gcgggccggg aggggctgcc ccaggccctg    180

 cgcctacccc atcaccgcgg ccggcgccgg gccgggagga tgcgcggtgt ggggctctga    240

 agc  atg gag ggg gtg ttg tac aag tgg acc aac tat ctc aca ggc tgg     288
      Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Thr Gly Trp
        1               5                  10                  15

 cag cct cgt tgg ttt gtt tta gat aat gga atc tta tcc tac tat gat      336
 Gln Pro Arg Trp Phe Val Leu Asp Asn Gly Ile Leu Ser Tyr Tyr Asp
                  20                  25                  30

 tca caa gat gat gtt tgc aaa ggg agc aaa gga agc ata aag atg gca      384
 Ser Gln Asp Asp Val Cys Lys Gly Ser Lys Gly Ser Ile Lys Met Ala
              35                  40                  45

 gtt tgt gaa att aaa gtt cat tca gca gac aac aca aga atg gaa tta      432
 Val Cys Glu Ile Lys Val His Ser Ala Asp Asn Thr Arg Met Glu Leu
          50                  55                  60

 atc att cct gga gag cag cat ttc tac atg aag gca gtg aat gca gct      480
 Ile Ile Pro Gly Glu Gln His Phe Tyr Met Lys Ala Val Asn Ala Ala
      65                  70                  75

 gaa aga cag agg tgg ctg gtc gct ctg ggg agc tcc aaa gca tgt ttg      528
 Glu Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ser Lys Ala Cys Leu
  80                  85                  90                  95

 act gat aca agg act aaa aaa gaa aaa gaa ata agt gaa acc agt gaa      576
 Thr Asp Thr Arg Thr Lys Lys Glu Lys Glu Ile Ser Glu Thr Ser Glu
                 100                 105                 110

 tcg ctg aaa acc aaa atg tct gaa ctt cgc ctc tac tgt gac ctc tta      624
 Ser Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu
             115                 120                 125

 atg cag caa gtt cat aca ata cag gaa ttt gtt cac cat gat gag aat      672
 Met Gln Gln Val His Thr Ile Gln Glu Phe Val His His Asp Glu Asn
         130                 135                 140

 cat tca tct cct agt gca gag aac atg aat gaa gcc tct tct ctg ctt      720
 His Ser Ser Pro Ser Ala Glu Asn Met Asn Glu Ala Ser Ser Leu Leu
     145                 150                 155

 agt gcc acg tgt aac aca ttc atc aca acg ctt gag gaa tgt gtg aag      768
 Ser Ala Thr Cys Asn Thr Phe Ile Thr Thr Leu Glu Glu Cys Val Lys
 160                 165                 170                 175

 ata gcc aat gcc aag ttt aaa cct gag atg ttt caa ctg cac cat ccg      816
 Ile Ala Asn Ala Lys Phe Lys Pro Glu Met Phe Gln Leu His His Pro
                 180                 185                 190

 gat ccc tta gtt tct cct gtg tca cct tct cct gtt caa atg atg aag      864
 Asp Pro Leu Val Ser Pro Val Ser Pro Ser Pro Val Gln Met Met Lys
             195                 200                 205

 cgt tct gtc agc cac cct ggt tct tgc agt tca gag agg agt agc cac      912
 Arg Ser Val Ser His Pro Gly Ser Cys Ser Ser Glu Arg Ser Ser His
         210                 215                 220

 tct ata aaa gaa cca gta tct aca ctt cac cga ctc tcc cag cga cgc      960
 Ser Ile Lys Glu Pro Val Ser Thr Leu His Arg Leu Ser Gln Arg Arg
     225                 230                 235

 cga aga acc tac tca gat aca gat tct tgt agt gat att cct ctt gaa     1008
 Arg Arg Thr Tyr Ser Asp Thr Asp Ser Cys Ser Asp Ile Pro Leu Glu
 240                 245                 250                 255

 gac cca gat aga cct gtt cac tgt tca aaa aat aca ctt aat gga gat     1056
 Asp Pro Asp Arg Pro Val His Cys Ser Lys Asn Thr Leu Asn Gly Asp
                 260                 265                 270

 ttg gca tca gca acc att cct gaa gaa agc aga ctt atg gcc aaa aaa     1104
 Leu Ala Ser Ala Thr Ile Pro Glu Glu Ser Arg Leu Met Ala Lys Lys
             275                 280                 285

 caa tct gaa tca gaa gat act ctt cca tcc ttc tct tcc tga agaaact     1153
 Gln Ser Glu Ser Glu Asp Thr Leu Pro Ser Phe Ser Ser 
         290                 295                 300

 gaagtgtcca acttcctcta agtattgcta tgcaaaagct gctgtaatta aactattgtt   1213

 atagggagta gttttttccc ttaggactct gcactttata gaatgttgta aaacagacaa   1273

 acaagaaaac aaaccacata cttttgaagt gtattttatc tttatatagt ttgtttgcaa   1333

 gagtattttc ctaataactt cacagtatga atgtgcatct tttttttttg aacaaatgat   1393

 ggtgtaacat tttgacatcc ataaggacaa atgtagatat ttttcttaaa aactctgagg   1453

 ggactgacag catggtcagg gtgtattgta gcttataaac atgaaatctt ataaggtttc   1513

 agtttgacag aagtgtgata tatgtaactt gtgccatgga ccaaatggtc actttaccac   1573

 agctaaaaat gagttacgat agcagcttga tggtgattgt attgtattcc tttaatcaaa   1633

 aaggaaacac aatattctaa gtatctttag cccaaatacc atgacatatt gagcatcttt   1693

 aaataaccag actgtattgt ccttcatatg tgaagttgac actactgatt tgtcaatacc   1753

 aaattttggg ttaaagtgtt taatttttat gtatttattt tcttgttgcc tcaaaagatg   1813

 attgcattct aacttttgtg acctaccaaa tttaagatgt gtatacgttg ttctttacgt   1873

 tgttctagaa aagagatttt aatgctgtag tgactttgct cacttacact agagaaataa   1933

 acaactttca atggaagaga attttagtgc tttttttttc ctaaaataga tattaagctg   1993

 ctgttgtaaa gtattgtttg cagctctttc caatatctag agacattttt atttatgaat   2053

 atttatacaa aaaggaattc tgtcaagatg actgctctat atcacttgag aatggcatta   2113

 tttaattaaa gaacaaatag cattttttgg tagtgcctgt ccatacctat tgtcattgtt   2173

 tgccttgtaa tctgtttttt tgaattcatt ttgggctgat agttttgttt aaggttttgg   2233

 ataaggagca ctttaaaaca aactggtgtg ttgtttttaa gttaatcata tgtttaataa   2293

 atgcgtggtt tttgcattca aaaaaaaaaa a                                  2324




      <210> 95
      <211> 1788
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(777)

      <400> 95
 tgccttcact cttccttctg cgcatgtgct cagttcgcta tccggctgct tgtacctggt     60

 tcaggaggtt caggcagagg ttgcacccac tacgcctgcg caacctcagc cccgcccctc    120

 cgctgctttc cccggaaacg tttctttcct acgcagccgc tcctgccgcc gtggtcgctg    180

 gagctttgcc tctctaggcc ggcagcgcct ctcctccatg gtcctgtctg tcagcgctgt    240

 tttgggagcc cgccggtgag gccgggccac gctcagacac ttcgatcgtc gagtctgtca    300

 ctgggc   atg gcg ggt cag ttc cgc agc tac gtg tgg gac ccg ctg ctg     348
          Met Ala Gly Gln Phe Arg Ser Tyr Val Trp Asp Pro Leu Leu
            1               5                  10

 atc ctg tcg cag atc gtc ctc atg cag acc gtg tat tac ggc tcg ctg      396
 Ile Leu Ser Gln Ile Val Leu Met Gln Thr Val Tyr Tyr Gly Ser Leu
  15                  20                  25                  30

 ggc ctg tgg ctg gcg ctg gtg gac ggg cta gtg cga agc agc ccc tcg      444
 Gly Leu Trp Leu Ala Leu Val Asp Gly Leu Val Arg Ser Ser Pro Ser
                  35                  40                  45

 ctg gac cag atg ttc gac gcc gag atc ctg ggc ttt tcc acc cct cca      492
 Leu Asp Gln Met Phe Asp Ala Glu Ile Leu Gly Phe Ser Thr Pro Pro
              50                  55                  60

 ggc cgg ctc tcc atg atg tcc ttc atc ctc aac gcc ctc acc tgt gcc      540
 Gly Arg Leu Ser Met Met Ser Phe Ile Leu Asn Ala Leu Thr Cys Ala
          65                  70                  75

 ctg ggc ttg ctg tac ttc atc cgg cga gga aag cag tgt ctg gat ttc      588
 Leu Gly Leu Leu Tyr Phe Ile Arg Arg Gly Lys Gln Cys Leu Asp Phe
      80                  85                  90

 act gtc act gtc cat ttc ttt cac ctc ctg ggc tgc tgg ttc tac agc      636
 Thr Val Thr Val His Phe Phe His Leu Leu Gly Cys Trp Phe Tyr Ser
  95                 100                 105                 110

 tcc cgt ttc ccc tcg gcg ctg acc tgg tgg ctg gtc caa gcc gtg tgc      684
 Ser Arg Phe Pro Ser Ala Leu Thr Trp Trp Leu Val Gln Ala Val Cys
                 115                 120                 125

 att gca ctc atg gct gtc atc ggg gag tac ctg tgc atg cgg acg gag      732
 Ile Ala Leu Met Ala Val Ile Gly Glu Tyr Leu Cys Met Arg Thr Glu
             130                 135                 140

 ctc aag gag ata ccc ctc aac tca gcc cct aaa tcc aat gtc tag aat      780
 Leu Lys Glu Ile Pro Leu Asn Ser Ala Pro Lys Ser Asn Val 
         145                 150                 155

 caggcccttt ggacatcctg ctgacacttg ggccccttaa caccttgggc tgctcagacc    840

 ctccagatga ggtccagccc agatctgaga ggaaccctgg aaatgtgaag tctctgttgg    900

 tgtgggagag atagtgaggg cctgtcaaag aaggcaggta gcagtcagca tgacagctgc    960

 aagaatgacc tctgtctgtt gaagccttgg tatctgagag gtcaggaagg ggacctcttt   1020

 gagggtaata acataattgg aaccatgcca ctcttgagcc acaatacctg tcaccagcct   1080

 gttgttttaa gagagaaaaa aaatcaagga tatttgattg gagcaaacca cttctttagt   1140

 catctgtctt acctccctgg gacagctgtt acctttgcag tgttgccgaa tcacagcagt   1200

 tacctttgca atgttgccga atcacagcag ttctgttgga gaaacgcttg gtttccggat   1260

 ccacagccac agaaagaaat gtaggtgtga agtattaggc tgctgtcagg gagaggatgg   1320

 cagatggagg catcaagcac aaggaaaatg cacaacctgt gccctgttat acacacgttc   1380

 atgtgcaccc aagaacctat gactttcttc cagttccttc taccaggtcc ccatcctgct   1440

 gccagctctc aacatagcag gccataggac ccagagaaga atcccagtgt tgctcaaagt   1500

 ctaaccatca taaagacact gcctgtcttc taggaatgac caggcaccca gctcccactg   1560

 gactccaatt ttttttcctg ccttatttag aattctttgg cgggaagggt atgatgggtt   1620

 cccagagaca agaagcccaa ccttctggcc tgggctgtgc tgatagtgct gagggagata   1680

 ggaatttgct gctaagattt ttctttgggg tggagtttcc tctgtgaggg gcttgcagct   1740

 atccttcctg tgtatacaaa tacagtattt tccatgaaaa aaaaaaaa                1788




      <210> 96
      <211> 1011
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(774)

      <400> 96
 cagctcgctg cttaaaatta aaccacaggt tccatt  atg ggt cga ctt gat ggg      54
                                          Met Gly Arg Leu Asp Gly
                                            1               5

 aaa gtc atc atc ctg acg gcc gct gct cag ggg att ggc caa gca gct      102
 Lys Val Ile Ile Leu Thr Ala Ala Ala Gln Gly Ile Gly Gln Ala Ala
              10                  15                  20

 gcc tta gct ttt gca aga gaa ggt gcc aaa gtc ata gcc aca gac att      150
 Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys Val Ile Ala Thr Asp Ile
          25                  30                  35

 aat gag tcc aaa ctt cag gaa ctg gaa aag tac ccg ggt att caa act      198
 Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys Tyr Pro Gly Ile Gln Thr
      40                  45                  50

 cgt gtc ctt gat gtc aca aag aag aaa caa att gat cag ttt gcc aat      246
 Arg Val Leu Asp Val Thr Lys Lys Lys Gln Ile Asp Gln Phe Ala Asn
  55                  60                  65                  70

 gaa gtt gag aga ctt gat gtt ctc ttt aat gtt gct ggt ttt gtc cat      294
 Glu Val Glu Arg Leu Asp Val Leu Phe Asn Val Ala Gly Phe Val His
                  75                  80                  85

 cat gga act gtc ctg gat tgt gag gag aaa gac tgg gac ttc tcg atg      342
 His Gly Thr Val Leu Asp Cys Glu Glu Lys Asp Trp Asp Phe Ser Met
              90                  95                 100

 aat ctc aat gtg cgc agc atg tac ctg atg atc aag gca ttc ctt cct      390
 Asn Leu Asn Val Arg Ser Met Tyr Leu Met Ile Lys Ala Phe Leu Pro
         105                 110                 115

 aaa atg ctt gct cag aaa tct ggc aat att atc aac atg tct tct gtg      438
 Lys Met Leu Ala Gln Lys Ser Gly Asn Ile Ile Asn Met Ser Ser Val
     120                 125                 130

 gct tcc agc gtc aaa gga gtt gtg aac aga tgt gtg tac agc aca acc      486
 Ala Ser Ser Val Lys Gly Val Val Asn Arg Cys Val Tyr Ser Thr Thr
 135                 140                 145                 150

 aag gca gcc gtg att ggc ctc aca aaa tct gtg gct gca gat ttc atc      534
 Lys Ala Ala Val Ile Gly Leu Thr Lys Ser Val Ala Ala Asp Phe Ile
                 155                 160                 165

 cag cag ggc atc agg tgc aac tgt gtg tgc cca gga aca gtt gat acg      582
 Gln Gln Gly Ile Arg Cys Asn Cys Val Cys Pro Gly Thr Val Asp Thr
             170                 175                 180

 cca tct cta caa gaa aga ata caa gcc aga gga aat cct gaa gag gca      630
 Pro Ser Leu Gln Glu Arg Ile Gln Ala Arg Gly Asn Pro Glu Glu Ala
         185                 190                 195

 cgg aat gat ttc ctg aag aga caa aag acg gga aga ttc gca act gca      678
 Arg Asn Asp Phe Leu Lys Arg Gln Lys Thr Gly Arg Phe Ala Thr Ala
     200                 205                 210

 gaa gaa ata gcc atg ctc tgc gtg tat ttg gct tct gat gaa tct gct      726
 Glu Glu Ile Ala Met Leu Cys Val Tyr Leu Ala Ser Asp Glu Ser Ala
 215                 220                 225                 230

 tat gta act ggt aac cct gtc atc att gat gga ggc tgg agc ttg tga      774
 Tyr Val Thr Gly Asn Pro Val Ile Ile Asp Gly Gly Trp Ser Leu 
                 235                 240                 245

 ttttaggatc tccatggtgg gaaggaaggc aggcccttcc tatccacagt gaacctggtt    834

 acgaagaaaa ctcaccaatc atctccttcc tgttaatcac atgttaatga aaataagctc    894

 tttttaatga tgtcactgtt tgcaagagtc tgattcttta agtatattaa tctctttgta    954

 atctcttctg aaatcattgt aaagaaataa aaatattgaa ctcataaaaa aaaaaaa      1011




      <210> 97
      <211> 1638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (676)..(1584)

      <400> 97
 cttaaatcta aagaacttgg ctaattcggg agatagccat atgaaaactt taaaacagaa     60

 gtatgggtag ctgacttgaa gtaactctat gtcaaatagt cgtaggttaa gtatcttcaa    120

 agaacttcga tattatttca gaggatacaa aataaaaata caaactggaa aataaagatt    180

 acagagaaaa aaccaacacc ttcctgtgca gtcctgttgg aattttcgtc attgaatttt    240

 gagaagcatt ctgaaaactt tgcatggaca gagaatcgtt atgatgtgaa ccgtcgacga    300

 cacaactctt cagatggctt tgattctgct attggacgtc ctaatggagg taactttgga    360

 aggaaagaaa aaaatggatg gcgtacacat ggaagaaatg gtacagaaaa cataaatcat    420

 cgaggtggat accatggtgg aagttcccgt tctcgtagca gtattttcca tgcaggaaaa    480

 agccaaggac tacatgaaaa caacatacct gacaatgaaa ccgggaggaa agaagacaag    540

 agagaacgca aacagtttga agctgaggat tttccgtctt taaatcctga gtatgagaga    600

 gaaccaaatc acaataagtc tttagctgca ggtgtgtggg aatatcctcc gaatcctaaa    660

 tctagagctc caagg atg ctg gtc att aag aaa ggt aat aca aaa gac tta     711
                  Met Leu Val Ile Lys Lys Gly Asn Thr Lys Asp Leu
                    1               5                  10

 cag cta tct gga ttc cca gta gta gga aat ctt ccg tca cag cca gtt      759
 Gln Leu Ser Gly Phe Pro Val Val Gly Asn Leu Pro Ser Gln Pro Val
          15                  20                  25

 aag aat gga act ggt cca agt gtt tat aaa ggt tta gtc cct aaa cct      807
 Lys Asn Gly Thr Gly Pro Ser Val Tyr Lys Gly Leu Val Pro Lys Pro
      30                  35                  40

 gct gct cca cct aca aaa cct aca caa tgg aaa agc caa aca aaa gaa      855
 Ala Ala Pro Pro Thr Lys Pro Thr Gln Trp Lys Ser Gln Thr Lys Glu
  45                  50                  55                  60

 aat aaa gtt gga act tct ttc cct cat gag tcc aca ttt ggc gtt ggc      903
 Asn Lys Val Gly Thr Ser Phe Pro His Glu Ser Thr Phe Gly Val Gly
                  65                  70                  75

 aac ttt aat gct ttt aaa tca act gcc aag aac ttt agt cca tct aca      951
 Asn Phe Asn Ala Phe Lys Ser Thr Ala Lys Asn Phe Ser Pro Ser Thr
              80                  85                  90

 aat tca gtg aaa gag tgt aat cgc tca aat tcc tct tct cct gtt gac      999
 Asn Ser Val Lys Glu Cys Asn Arg Ser Asn Ser Ser Ser Pro Val Asp
          95                 100                 105

 aaa ctt aat cag cag cct cgt cta acc aaa ctg aca cga atg cgc act     1047
 Lys Leu Asn Gln Gln Pro Arg Leu Thr Lys Leu Thr Arg Met Arg Thr
     110                 115                 120

 gat aag aag agt gaa ttt ttg aaa gca ttg aaa aga gac aga gta gaa     1095
 Asp Lys Lys Ser Glu Phe Leu Lys Ala Leu Lys Arg Asp Arg Val Glu
 125                 130                 135                 140

 gag gaa cat gaa gat gaa agc cgt gct ggc tca gag aag gat gac gac     1143
 Glu Glu His Glu Asp Glu Ser Arg Ala Gly Ser Glu Lys Asp Asp Asp
                 145                 150                 155

 tca ttt aat tta cat aac agc aat agt act cac caa gaa agg gat ata     1191
 Ser Phe Asn Leu His Asn Ser Asn Ser Thr His Gln Glu Arg Asp Ile
             160                 165                 170

 aac cga aac ttc gat gaa aat gaa att cct caa gag aat ggc aat gcc     1239
 Asn Arg Asn Phe Asp Glu Asn Glu Ile Pro Gln Glu Asn Gly Asn Ala
         175                 180                 185

 tca gtg att tcc cag cag atc att cgg tct tca acc ttc cca caa act     1287
 Ser Val Ile Ser Gln Gln Ile Ile Arg Ser Ser Thr Phe Pro Gln Thr
     190                 195                 200

 gat gtt ctt tca agt tca ctt gag gca gaa cac aga ttg tta aag gaa     1335
 Asp Val Leu Ser Ser Ser Leu Glu Ala Glu His Arg Leu Leu Lys Glu
 205                 210                 215                 220

 atg ggc tgg cag gaa gac agt gaa aat gat gaa aca tgt gct ccc tta     1383
 Met Gly Trp Gln Glu Asp Ser Glu Asn Asp Glu Thr Cys Ala Pro Leu
                 225                 230                 235

 act gag gat gaa atg aga gaa ttc caa gtt att agt gaa cag tta cag     1431
 Thr Glu Asp Glu Met Arg Glu Phe Gln Val Ile Ser Glu Gln Leu Gln
             240                 245                 250

 aag aat ggt ctg aga aaa aat ggt att ttg aaa aat ggc ttg atc tgt     1479
 Lys Asn Gly Leu Arg Lys Asn Gly Ile Leu Lys Asn Gly Leu Ile Cys
         255                 260                 265

 gac ttc aag ttt gga ccg tgg aag aac agc act ttc aaa ccc aca act     1527
 Asp Phe Lys Phe Gly Pro Trp Lys Asn Ser Thr Phe Lys Pro Thr Thr
     270                 275                 280

 gag aat gat gac aca gag aca agt agc agt gat aca tca gat gac gac     1575
 Glu Asn Asp Asp Thr Glu Thr Ser Ser Ser Asp Thr Ser Asp Asp Asp
 285                 290                 295                 300

 gat gtg tga aggattt cctaacagct ttagaaatct tagtgtgata catctctcat     1631
 Asp Val 


 acagttt                                                             1638




      <210> 98
      <211> 2601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(2269)

      <400> 98
 agcaacatgg ccgccgcctg agaggagagc cgggccgccg ccgtctctgc agcccgcggg     60

 taactgggcc gttgccgccg tccgcgctcg gcccccgcgg agagatcgag ctgaaggact    120

 gcgcggctgg ctctcctcta gt atg gcc aat gaa gag gat gac cca gtt gta     172
                          Met Ala Asn Glu Glu Asp Asp Pro Val Val
                            1               5                  10

 cag gag atc gat gtg tac ttg gcc aag agt ctg gcg gaa aag ctg tat      220
 Gln Glu Ile Asp Val Tyr Leu Ala Lys Ser Leu Ala Glu Lys Leu Tyr
                  15                  20                  25

 cta ttt cag tac cct gtg cgt cca gcc tcg atg acc tac gat gac att      268
 Leu Phe Gln Tyr Pro Val Arg Pro Ala Ser Met Thr Tyr Asp Asp Ile
              30                  35                  40

 ccg cac ctc tca gcc aag atc aag ccc aag cag cag aag gta gag ctt      316
 Pro His Leu Ser Ala Lys Ile Lys Pro Lys Gln Gln Lys Val Glu Leu
          45                  50                  55

 gag atg gcc atc gac acc ctg aac ccc aac tat tgc cgc agc aaa ggg      364
 Glu Met Ala Ile Asp Thr Leu Asn Pro Asn Tyr Cys Arg Ser Lys Gly
      60                  65                  70

 gag cag att gcg ctg aac gtg gac ggg gcc tgc gcc gac gag acc agc      412
 Glu Gln Ile Ala Leu Asn Val Asp Gly Ala Cys Ala Asp Glu Thr Ser
  75                  80                  85                  90

 acg tat tcc tcg aag ctg atg gac aag cag acc ttc tgc tct tcc cag      460
 Thr Tyr Ser Ser Lys Leu Met Asp Lys Gln Thr Phe Cys Ser Ser Gln
                  95                 100                 105

 acc acc agt aac aca tcc cgt tat gcc gct gca ctc tac agg caa ggt      508
 Thr Thr Ser Asn Thr Ser Arg Tyr Ala Ala Ala Leu Tyr Arg Gln Gly
             110                 115                 120

 gag ctc cac ctg aca cct tta cat ggc atc ctg cag ctg cgg ccc agc      556
 Glu Leu His Leu Thr Pro Leu His Gly Ile Leu Gln Leu Arg Pro Ser
         125                 130                 135

 ttc tcc tac ctg gat aag gct gac gcc aag cac cgg gag agg gag gcg      604
 Phe Ser Tyr Leu Asp Lys Ala Asp Ala Lys His Arg Glu Arg Glu Ala
     140                 145                 150

 gcc aac gag gca ggg gac tct tca cag gat gag gcg gaa gac gat gtt      652
 Ala Asn Glu Ala Gly Asp Ser Ser Gln Asp Glu Ala Glu Asp Asp Val
 155                 160                 165                 170

 aag cag atc acg gtg cgg ttc tcc cgg ccg gag tca gag cag gcc cgc      700
 Lys Gln Ile Thr Val Arg Phe Ser Arg Pro Glu Ser Glu Gln Ala Arg
                 175                 180                 185

 cag cgc cgt gtg cag tcc tat gag ttc ctg cag aag aag cac gca gag      748
 Gln Arg Arg Val Gln Ser Tyr Glu Phe Leu Gln Lys Lys His Ala Glu
             190                 195                 200

 gag ccc tgg gtc cac ctg cat tac tat ggc ctg agg gac agt cgc tct      796
 Glu Pro Trp Val His Leu His Tyr Tyr Gly Leu Arg Asp Ser Arg Ser
         205                 210                 215

 gag cat gag cgt cag tac ctg ctg tgc ccc ggc tca agc ggg gtg gag      844
 Glu His Glu Arg Gln Tyr Leu Leu Cys Pro Gly Ser Ser Gly Val Glu
     220                 225                 230

 aac acg gag ctc gtc aag tca ccc agt gag tac ctg atg atg ctg atg      892
 Asn Thr Glu Leu Val Lys Ser Pro Ser Glu Tyr Leu Met Met Leu Met
 235                 240                 245                 250

 cca ccc agc cag gag gag gag aaa gac aag cct gtg gcc ccc agc aac      940
 Pro Pro Ser Gln Glu Glu Glu Lys Asp Lys Pro Val Ala Pro Ser Asn
                 255                 260                 265

 gtc ctg tcg atg gcc cag ctg cgc acg ctg ccc ctg gcc gat cag atc      988
 Val Leu Ser Met Ala Gln Leu Arg Thr Leu Pro Leu Ala Asp Gln Ile
             270                 275                 280

 aag atc ctg atg aag aat gtg aag gtc atg cct ttt gcc aac ttg atg     1036
 Lys Ile Leu Met Lys Asn Val Lys Val Met Pro Phe Ala Asn Leu Met
         285                 290                 295

 agc ctc ctg ggc ccc tcc atc gat tcc gtg gct gtt ctg cgg ggc atc     1084
 Ser Leu Leu Gly Pro Ser Ile Asp Ser Val Ala Val Leu Arg Gly Ile
     300                 305                 310

 cag aag gtg gcg atg ttg gtc caa ggg aac tgg gtg gtg aag agt gac     1132
 Gln Lys Val Ala Met Leu Val Gln Gly Asn Trp Val Val Lys Ser Asp
 315                 320                 325                 330

 atc cta tac ccc aag gac tcg tcc agc cct cac agc ggc gtg cct gct     1180
 Ile Leu Tyr Pro Lys Asp Ser Ser Ser Pro His Ser Gly Val Pro Ala
                 335                 340                 345

 gag gtg ctc tgc agg ggc cga gac ttc gtt atg tgg aag ttc acg cag     1228
 Glu Val Leu Cys Arg Gly Arg Asp Phe Val Met Trp Lys Phe Thr Gln
             350                 355                 360

 agc cgc tgg gtg gtt agg aaa gag gtg gca acc gtg acc aaa ctc tgc     1276
 Ser Arg Trp Val Val Arg Lys Glu Val Ala Thr Val Thr Lys Leu Cys
         365                 370                 375

 gcc gag gat gtg aag gac ttc ctg gag cac atg gcc gtg gtg agg atc     1324
 Ala Glu Asp Val Lys Asp Phe Leu Glu His Met Ala Val Val Arg Ile
     380                 385                 390

 aac aaa ggc tgg gag ttc att ctg cct tat gat ggg gag ttc atc aag     1372
 Asn Lys Gly Trp Glu Phe Ile Leu Pro Tyr Asp Gly Glu Phe Ile Lys
 395                 400                 405                 410

 aag cac ccg gat gtg gtc cag cgg cag cac atg ctg tgg acg ggt atc     1420
 Lys His Pro Asp Val Val Gln Arg Gln His Met Leu Trp Thr Gly Ile
                 415                 420                 425

 cag gcc aaa ctg gaa aaa gtc tat aat ctt gta aag gaa acc atg cca     1468
 Gln Ala Lys Leu Glu Lys Val Tyr Asn Leu Val Lys Glu Thr Met Pro
             430                 435                 440

 aag aag ccg gat gca caa tca ggg cct gcc ggg ctg gtc tgt ggg gac     1516
 Lys Lys Pro Asp Ala Gln Ser Gly Pro Ala Gly Leu Val Cys Gly Asp
         445                 450                 455

 cag cgg atc caa gta gcc aaa acc aag gcc cag cag aac cac gcg ttg     1564
 Gln Arg Ile Gln Val Ala Lys Thr Lys Ala Gln Gln Asn His Ala Leu
     460                 465                 470

 ctg gag cgg gag ctg cag cgg cgg aag gag cag ctg cgg gtg cct gcg     1612
 Leu Glu Arg Glu Leu Gln Arg Arg Lys Glu Gln Leu Arg Val Pro Ala
 475                 480                 485                 490

 gtc ccg ccc ggt gtg cgg atc aag gag gag ccc gtg agc gag gag ggc     1660
 Val Pro Pro Gly Val Arg Ile Lys Glu Glu Pro Val Ser Glu Glu Gly
                 495                 500                 505

 gag gag gac gag gag cag gag gcg gag gag gag ccc atg gac act tcc     1708
 Glu Glu Asp Glu Glu Gln Glu Ala Glu Glu Glu Pro Met Asp Thr Ser
             510                 515                 520

 ccc agc ggc ctc cac agc aag ctg gcc aac ggg ctg cct ctc ggg cgg     1756
 Pro Ser Gly Leu His Ser Lys Leu Ala Asn Gly Leu Pro Leu Gly Arg
         525                 530                 535

 gct gcg ggc aca gac agc ttc aac ggg cac ccg ccc cag ggc tgc gcc     1804
 Ala Ala Gly Thr Asp Ser Phe Asn Gly His Pro Pro Gln Gly Cys Ala
     540                 545                 550

 agc acc cct gtg gct cgg gaa ctg aag gcc ttc gtg gag gcc acc ttt     1852
 Ser Thr Pro Val Ala Arg Glu Leu Lys Ala Phe Val Glu Ala Thr Phe
 555                 560                 565                 570

 cag aga cag ttt gtg ctc acg ctg agc gaa ctc aag cgc ctc ttc aat     1900
 Gln Arg Gln Phe Val Leu Thr Leu Ser Glu Leu Lys Arg Leu Phe Asn
                 575                 580                 585

 ctg cac ttg gcc agc ctg ccc ccc ggc cac aca ctc ttc agc ggc atc     1948
 Leu His Leu Ala Ser Leu Pro Pro Gly His Thr Leu Phe Ser Gly Ile
             590                 595                 600

 tcg gac cgc atg cta cag gac acg gtg ctg gcc gcc ggt tgc aag cag     1996
 Ser Asp Arg Met Leu Gln Asp Thr Val Leu Ala Ala Gly Cys Lys Gln
         605                 610                 615

 ata ctg gtg cct ttt ccc ccc cag act gct gct tcc ccg gat gag cag     2044
 Ile Leu Val Pro Phe Pro Pro Gln Thr Ala Ala Ser Pro Asp Glu Gln
     620                 625                 630

 aag gtg ttt gcc ctc tgg gag tct gga gac atg agt gat cag cat cga     2092
 Lys Val Phe Ala Leu Trp Glu Ser Gly Asp Met Ser Asp Gln His Arg
 635                 640                 645                 650

 cag gtt ttg ctt gaa att ttt tcc aaa aat tac cgg gta cgc cga aac     2140
 Gln Val Leu Leu Glu Ile Phe Ser Lys Asn Tyr Arg Val Arg Arg Asn
                 655                 660                 665

 atg atc cag tct cgg ttg act caa gag tgt gga gaa gat ctc agt aaa     2188
 Met Ile Gln Ser Arg Leu Thr Gln Glu Cys Gly Glu Asp Leu Ser Lys
             670                 675                 680

 cag gag gtg gat aaa gta cta aag gac tgc tgt gta agc tat ggt ggc     2236
 Gln Glu Val Asp Lys Val Leu Lys Asp Cys Cys Val Ser Tyr Gly Gly
         685                 690                 695

 atg tgg tac ctt aaa ggg aca gta cag tct tga caatagta gcaaactact     2287
 Met Trp Tyr Leu Lys Gly Thr Val Gln Ser 
     700                 705

 aacccagcaa atctaagccc aaggaagaag ggcggaacca gaagtagggc ctcgacttgc   2347

 ttcagacgac acagagcaag aggaactgac catctcatga cctgtggcat tgcacggtgc   2407

 agtggacaga agggattatc ctcagccagt cgcagggtca gcttaagtta gttagatcac   2467

 tcccagaaga gaccagctgg gaccttcttt gcagtacaat ttgaaattcc tgatgtattt   2527

 tgcttattat ttggtttcat tctcataata aagagagtgt atactgacat gggcaggatg   2587

 ataaaaaaaa aaaa                                                     2601




      <210> 99
      <211> 1817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1385)

      <400> 99
 tcgccgattt cgtgcggaag gttgaatgcg tcgggtgggc acctcagcaa ccagtagcc      59                                                                 
 atg cgc ggc ttg gag gag ccg ggg cct cgg cct aca gcg acc ccg tgc      107
 Met Arg Gly Leu Glu Glu Pro Gly Pro Arg Pro Thr Ala Thr Pro Cys
   1               5                  10                  15

 ggc tgc gtt aag ccg gct ctg gag aca ggg aat ctt tta act gag cca      155
 Gly Cys Val Lys Pro Ala Leu Glu Thr Gly Asn Leu Leu Thr Glu Pro
              20                  25                  30

 gtc ggc tac ttg gaa tct tgt ttc tcg gcc aag aat ggt act cca aga      203
 Val Gly Tyr Leu Glu Ser Cys Phe Ser Ala Lys Asn Gly Thr Pro Arg
          35                  40                  45

 cag cca tcc att tgt agc tat tct cga gcc tgt ttg agg att aga aag      251
 Gln Pro Ser Ile Cys Ser Tyr Ser Arg Ala Cys Leu Arg Ile Arg Lys
      50                  55                  60

 agg atc ttt aat aat cct gaa cat tcc ttg atg ggc cta gaa cag ttt      299
 Arg Ile Phe Asn Asn Pro Glu His Ser Leu Met Gly Leu Glu Gln Phe
  65                  70                  75                  80

 tct cat gtt tgg att ttg ttt gtt ttt cac aaa aat ggt cat ttg agc      347
 Ser His Val Trp Ile Leu Phe Val Phe His Lys Asn Gly His Leu Ser
                  85                  90                  95

 tgt aag gca aaa gtg cag cct cct agg ctg aat ggt gca aag act gga      395
 Cys Lys Ala Lys Val Gln Pro Pro Arg Leu Asn Gly Ala Lys Thr Gly
             100                 105                 110

 gtt ttt tcc aca agg agc cct cat cgt ccc aat gca ata gga ctg acc      443
 Val Phe Ser Thr Arg Ser Pro His Arg Pro Asn Ala Ile Gly Leu Thr
         115                 120                 125

 ctg gcc aag ctg gaa aag gta gaa ggt gga gct ata tac ctt tct gga      491
 Leu Ala Lys Leu Glu Lys Val Glu Gly Gly Ala Ile Tyr Leu Ser Gly
     130                 135                 140

 att gac atg ata cat ggc aca ccc gta cta gac atc aag ccc tac ata      539
 Ile Asp Met Ile His Gly Thr Pro Val Leu Asp Ile Lys Pro Tyr Ile
 145                 150                 155                 160

 gct gag tat gac tca ccg caa aat gtg atg gag cct tta gca gac ttt      587
 Ala Glu Tyr Asp Ser Pro Gln Asn Val Met Glu Pro Leu Ala Asp Phe
                 165                 170                 175

 aat tta cag aat aac caa cat aca cca aac act gtg tcc cag tct gac      635
 Asn Leu Gln Asn Asn Gln His Thr Pro Asn Thr Val Ser Gln Ser Asp
             180                 185                 190

 agc aag act gac agc tgt gac cag cga cag ctc tca ggg tgt gat gag      683
 Ser Lys Thr Asp Ser Cys Asp Gln Arg Gln Leu Ser Gly Cys Asp Glu
         195                 200                 205

 cca caa ccc cac cat agc act aag agg aaa cct aaa tgt cct gaa gac      731
 Pro Gln Pro His His Ser Thr Lys Arg Lys Pro Lys Cys Pro Glu Asp
     210                 215                 220

 aga act tca gaa gaa aac tac ctg aca cac agt gac aca gcc aga att      779
 Arg Thr Ser Glu Glu Asn Tyr Leu Thr His Ser Asp Thr Ala Arg Ile
 225                 230                 235                 240

 cag caa gca ttt cct atg cac agg gag ata gca gtg gat ttt ggt ttg      827
 Gln Gln Ala Phe Pro Met His Arg Glu Ile Ala Val Asp Phe Gly Leu
                 245                 250                 255

 gaa tca aga cgt gat cag agt tcc agc gtg gca gaa gaa caa att ggc      875
 Glu Ser Arg Arg Asp Gln Ser Ser Ser Val Ala Glu Glu Gln Ile Gly
             260                 265                 270

 cca tat tgc cca gag aag agc ttt tca gag aaa ggt aca gac aag aag      923
 Pro Tyr Cys Pro Glu Lys Ser Phe Ser Glu Lys Gly Thr Asp Lys Lys
         275                 280                 285

 cta gaa aga gtg gaa gga gca gca gtc ttg caa gga agc agg gca gag      971
 Leu Glu Arg Val Glu Gly Ala Ala Val Leu Gln Gly Ser Arg Ala Glu
     290                 295                 300

 aca cag ccc atg gcc cct cac tgc cct gct gga agg gct gat gga gct     1019
 Thr Gln Pro Met Ala Pro His Cys Pro Ala Gly Arg Ala Asp Gly Ala
 305                 310                 315                 320

 ccc cgc agc gtg gtt cct gcc tgg gtg aca gag gct cct gtg gcc act     1067
 Pro Arg Ser Val Val Pro Ala Trp Val Thr Glu Ala Pro Val Ala Thr
                 325                 330                 335

 tta gaa gtg cgg ttt act cct cat gcc gag atg gac ctt ggg cag ctc     1115
 Leu Glu Val Arg Phe Thr Pro His Ala Glu Met Asp Leu Gly Gln Leu
             340                 345                 350

 agt tca caa gat gtt gat cag gcg tca ttt aaa tat ttt cag tca gca     1163
 Ser Ser Gln Asp Val Asp Gln Ala Ser Phe Lys Tyr Phe Gln Ser Ala
         355                 360                 365

 gag gaa gca aag cgt gcc att gag gct gtg ctg tca gcg gat cct cgg     1211
 Glu Glu Ala Lys Arg Ala Ile Glu Ala Val Leu Ser Ala Asp Pro Arg
     370                 375                 380

 tct gtg tac cgc cgg aag ctt tgc cag gac cgc ctt ttc tac ttt act     1259
 Ser Val Tyr Arg Arg Lys Leu Cys Gln Asp Arg Leu Phe Tyr Phe Thr
 385                 390                 395                 400

 gta gac ata gcg cat gtc act tgc tgg ttt ggt gat ggc ttt gca gag     1307
 Val Asp Ile Ala His Val Thr Cys Trp Phe Gly Asp Gly Phe Ala Glu
                 405                 410                 415

 gtg ctg agg atc aag ccg gct tct gag cct gtt cat atg act ggc cct     1355
 Val Leu Arg Ile Lys Pro Ala Ser Glu Pro Val His Met Thr Gly Pro
             420                 425                 430

 gtg ggg tcc ttg gtg tct cta ggg tct taa g gagcctccct catgtcttta     1406
 Val Gly Ser Leu Val Ser Leu Gly Ser 
         435                 440

 aggtagcatc attgatcttt ggatgtggct tttggatttt ctgaacaagc taatgttgtg   1466

 tcaagaagca acactttgtg atctcatggc tttgattgat ttgggctgtt caaaatgttt   1526

 atttgaaaaa cgtatacatt aataaactta acaaagagat ataaaataca gagaaatcac   1586

 caaatgcttt ttgatctgtt gatattaaag aatcaaaagg tgatgctgtc tcgataattt   1646

 ctgaaagaag ctgttcttgg tgcacttgat aaaattagac aaagttcatt ccagcagaga   1706

 ctttctagtt gaggggatct attcagtaat tcatattggt tttcctgtct gtctggaaaa   1766

 gcctgacctt tctatttgat tccaaatcaa acctatatca ggaagctagc g            1817




      <210> 100
      <211> 1720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1647)

      <400> 100
 cggacggcgg cacgagtcgg tgtcacgttt cgcttctgct tgagtcagtc ctcacggtaa     60

 tcaagtgaaa aa    atg agc ttc atc tgt gga ttg cag tct gct gct aga     108
                  Met Ser Phe Ile Cys Gly Leu Gln Ser Ala Ala Arg
                    1               5                  10

 aac cat gtt ttc ttc cga ttt aat tca ctg tct aac tgg aga aaa tgt      156
 Asn His Val Phe Phe Arg Phe Asn Ser Leu Ser Asn Trp Arg Lys Cys
          15                  20                  25

 aac aca tta gca tcc acc tca cgg ggc tgt cat caa gta caa gtt aac      204
 Asn Thr Leu Ala Ser Thr Ser Arg Gly Cys His Gln Val Gln Val Asn
      30                  35                  40

 cat ata gta aat aag tat cag gga ctg gga gta aat cag tgt gac agg      252
 His Ile Val Asn Lys Tyr Gln Gly Leu Gly Val Asn Gln Cys Asp Arg
  45                  50                  55                  60

 tgg agt ttt ctg cct gga aac ttt cat ttt tat agt act ttt aac aac      300
 Trp Ser Phe Leu Pro Gly Asn Phe His Phe Tyr Ser Thr Phe Asn Asn
                  65                  70                  75

 aaa aga aca gga ggc ctc tca agt acc aaa agt aag gaa att tgg agg      348
 Lys Arg Thr Gly Gly Leu Ser Ser Thr Lys Ser Lys Glu Ile Trp Arg
              80                  85                  90

 att acc agc aaa tgt act gta tgg aat gat gct ttt tca aga cag ctg      396
 Ile Thr Ser Lys Cys Thr Val Trp Asn Asp Ala Phe Ser Arg Gln Leu
          95                 100                 105

 cta ata aaa gaa gtt aca gca gtc cct agt ctg tca gta ttg cat cct      444
 Leu Ile Lys Glu Val Thr Ala Val Pro Ser Leu Ser Val Leu His Pro
     110                 115                 120

 cta agc cct gct tcc ata aga gct att agg aat ttc cat act tct cca      492
 Leu Ser Pro Ala Ser Ile Arg Ala Ile Arg Asn Phe His Thr Ser Pro
 125                 130                 135                 140

 cgg ttt caa gct gct ccg gtt cct ctc ttg ttg atg att ctt aaa cca      540
 Arg Phe Gln Ala Ala Pro Val Pro Leu Leu Leu Met Ile Leu Lys Pro
                 145                 150                 155

 gta cag aag tta ttt gca atc att gta ggc agg ggc ata agg aaa tgg      588
 Val Gln Lys Leu Phe Ala Ile Ile Val Gly Arg Gly Ile Arg Lys Trp
             160                 165                 170

 tgg cag gca ctt cct cct aac aag aag gaa gta gtt aaa gaa aat ata      636
 Trp Gln Ala Leu Pro Pro Asn Lys Lys Glu Val Val Lys Glu Asn Ile
         175                 180                 185

 agg aag aat aaa tgg aag cta ttc ctt ggt ttg agt agt ttt gga ttg      684
 Arg Lys Asn Lys Trp Lys Leu Phe Leu Gly Leu Ser Ser Phe Gly Leu
     190                 195                 200

 ctc ttt gtg gtg ttt tat ttt act cac ctg gaa gta agt cca atc aca      732
 Leu Phe Val Val Phe Tyr Phe Thr His Leu Glu Val Ser Pro Ile Thr
 205                 210                 215                 220

 gga agg agc aag cta cta tta ttg ggg aaa gaa cag ttc aga ctt tta      780
 Gly Arg Ser Lys Leu Leu Leu Leu Gly Lys Glu Gln Phe Arg Leu Leu
                 225                 230                 235

 tcg gaa ctg gaa tat gaa gca tgg atg gaa gaa ttt aaa aat gat atg      828
 Ser Glu Leu Glu Tyr Glu Ala Trp Met Glu Glu Phe Lys Asn Asp Met
             240                 245                 250

 cta act gag aaa gat gcc cga tac ctg gct gtt aaa gaa gtg ctt tgt      876
 Leu Thr Glu Lys Asp Ala Arg Tyr Leu Ala Val Lys Glu Val Leu Cys
         255                 260                 265

 cat cta att gaa tgc aat aaa gat gtt cca ggg atc tct cag atc aat      924
 His Leu Ile Glu Cys Asn Lys Asp Val Pro Gly Ile Ser Gln Ile Asn
     270                 275                 280

 tgg gtt att cat gtg gtt gat tcc cca att att aat gcc ttc gtg ctt      972
 Trp Val Ile His Val Val Asp Ser Pro Ile Ile Asn Ala Phe Val Leu
 285                 290                 295                 300

 cca aat gga caa atg ttt gtt ttc act gga ttt tta aat agt gta acc     1020
 Pro Asn Gly Gln Met Phe Val Phe Thr Gly Phe Leu Asn Ser Val Thr
                 305                 310                 315

 gat att cat caa ctt tct ttc ctt ctg ggc cat gaa cta gca cat gca     1068
 Asp Ile His Gln Leu Ser Phe Leu Leu Gly His Glu Leu Ala His Ala
             320                 325                 330

 gta ctt ggg cat gct gca gaa aag gct ggc atg gtt cat ttg ttg gat     1116
 Val Leu Gly His Ala Ala Glu Lys Ala Gly Met Val His Leu Leu Asp
         335                 340                 345

 ttc cta ggt atg att ttc ctc aca atg att tgg gcc att tgt cct cga     1164
 Phe Leu Gly Met Ile Phe Leu Thr Met Ile Trp Ala Ile Cys Pro Arg
     350                 355                 360

 gat agc ttg gca ctt ttg tgc cag tgg ata cag tct aaa ttg cag gag     1212
 Asp Ser Leu Ala Leu Leu Cys Gln Trp Ile Gln Ser Lys Leu Gln Glu
 365                 370                 375                 380

 tat atg ttt aat aga cca tac agc aga aaa ttg gag gcc gaa gct gac     1260
 Tyr Met Phe Asn Arg Pro Tyr Ser Arg Lys Leu Glu Ala Glu Ala Asp
                 385                 390                 395

 aaa att gga cta ctg ctt gct gca aag gct tgt gca gac ata aga gcc     1308
 Lys Ile Gly Leu Leu Leu Ala Ala Lys Ala Cys Ala Asp Ile Arg Ala
             400                 405                 410

 agt tca gtg ttt tgg cag caa atg gag ttc gtt gat agc ctg cat ggc     1356
 Ser Ser Val Phe Trp Gln Gln Met Glu Phe Val Asp Ser Leu His Gly
         415                 420                 425

 caa ccc aag atg cca gaa tgg tta tct aca cac cct tct cat ggc aat     1404
 Gln Pro Lys Met Pro Glu Trp Leu Ser Thr His Pro Ser His Gly Asn
     430                 435                 440

 cga gtt gag tac ttg gat aga ctt ata cct cag gct ctc aaa att aga     1452
 Arg Val Glu Tyr Leu Asp Arg Leu Ile Pro Gln Ala Leu Lys Ile Arg
 445                 450                 455                 460

 gag atg tgt aat tgt cca cca ctg tct aat cca gac cct cga tta cta     1500
 Glu Met Cys Asn Cys Pro Pro Leu Ser Asn Pro Asp Pro Arg Leu Leu
                 465                 470                 475

 ttc aaa ctc agc acg aag cat ttt ctt gaa gaa tca gag aaa gaa gac     1548
 Phe Lys Leu Ser Thr Lys His Phe Leu Glu Glu Ser Glu Lys Glu Asp
             480                 485                 490

 cta aat atc acg aag aaa cag aaa atg gat act ctt cct att caa aaa     1596
 Leu Asn Ile Thr Lys Lys Gln Lys Met Asp Thr Leu Pro Ile Gln Lys
         495                 500                 505

 cag gag caa ata cca tta aca tac ata gtt gag aaa aga acg ggc agt     1644
 Gln Glu Gln Ile Pro Leu Thr Tyr Ile Val Glu Lys Arg Thr Gly Ser
     510                 515                 520

 tga atta aaatttatga gacacaagat atatgaagaa tgttgcagtc cttatcattt     1701
 


 tatgttactt tttaaaaaa                                                1720




      <210> 101
      <211> 769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(642)

      <400> 101
 taagcttgcg gccgccgggg tagtggagag aactgggaac aggggtcctg gggtgtggga     60

 tgcggcccct ggggtggggg tgccggactg tgtggttctt gttcttagca aagtagtagg    120

 gcagccacgt ttttcactag gtcctcgtag cccgaggacc taataagaca caatagaaat    180

 gggctgatgt caaggggata gtgtttggag gtgggtaggg gctttgcctt gcccgtattg    240

 ggtagaacag ggacatcttt ttctttgggc cga atg att gga att gtt tcc gta     294
                                      Met Ile Gly Ile Val Ser Val
                                        1               5

 gtc gct gga gcc cca gcg gaa atg atc aga gag gac gat att att cgt      342
 Val Ala Gly Ala Pro Ala Glu Met Ile Arg Glu Asp Asp Ile Ile Arg
          10                  15                  20

 aaa ttt agg cga aag ggt cac att tca ccc caa tct gga tgt gtg ctt      390
 Lys Phe Arg Arg Lys Gly His Ile Ser Pro Gln Ser Gly Cys Val Leu
      25                  30                  35

 gcc gta atc gat tgg ttg cag cta tta act ctg gga ctg ggt ggt ttg      438
 Ala Val Ile Asp Trp Leu Gln Leu Leu Thr Leu Gly Leu Gly Gly Leu
  40                  45                  50                  55

 agg cga ggc tac agc ccc tcc ttc agt tca gac acg gct gat ttt agt      486
 Arg Arg Gly Tyr Ser Pro Ser Phe Ser Ser Asp Thr Ala Asp Phe Ser
                  60                  65                  70

 ata gtg ggg gtg ggg ggt ggg gga tgg atg tca cta ggg cga gat cta      534
 Ile Val Gly Val Gly Gly Gly Gly Trp Met Ser Leu Gly Arg Asp Leu
              75                  80                  85

 ggc ctg tca tta atc acc cac aag aac gcc act ttg gct gag tca aga      582
 Gly Leu Ser Leu Ile Thr His Lys Asn Ala Thr Leu Ala Glu Ser Arg
          90                  95                 100

 cct gtt tcc cta gca ggg tca aca aca aag aaa atg ctc ttc ccg agt      630
 Pro Val Ser Leu Ala Gly Ser Thr Thr Lys Lys Met Leu Phe Pro Ser
     105                 110                 115

 act gta ata tga tca cactataagt ctagaccttg agaaatgttg aacttttaat      685
 Thr Val Ile 
 120

 aagcatattg cattgaaaat tggggctgag gagttgcttt tatttggaaa tgttttattt    745

 ttgcccaaca aagtatgctg gggg                                           769




      <210> 102
      <211> 3383
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (408)..(2225)

      <400> 102
 accacaacaa ggtccagttc acccctactg ggggccttgg tctgaacttg gccctgaatc     60

 cgttcgagta ttacatattc ttctttgcct tgagcctcat cactcagaag ccacttcctg    120

 tgtccctcca cgtccgtact tcagactgtg cctatttcat cctggtggac aggtacctgt    180

 catggttcct gcccaccgaa ggcagtgtgc ccccaccact ctcctccagc ccagggggga    240

 ccagcccctc accacctccc aggacaccag ccataccctt tgcttcctat ggcctccacc    300

 acactagcct cctaaagcga cacatctctc atcagacatc tgtgaatgca gaccccgcct    360

 cccacgagat ctggaggtca gaaactctgc tccaggtttt tgttgaa  atg tgg ctt     416
                                                      Met Trp Leu
                                                        1

 cat cac tat tcc ttg gag atg tat caa aaa atg cag tcc cct cat gcc      464
 His His Tyr Ser Leu Glu Met Tyr Gln Lys Met Gln Ser Pro His Ala
       5                  10                  15

 aag ctg gag gtt ctg cac tac cga ctc agt gtc tcc agc gcc ctc tac      512
 Lys Leu Glu Val Leu His Tyr Arg Leu Ser Val Ser Ser Ala Leu Tyr
  20                  25                  30                  35

 agc ccc gcc caa ccc agc ctc cag gcc ctc cac gcc tac cag gag tcg      560
 Ser Pro Ala Gln Pro Ser Leu Gln Ala Leu His Ala Tyr Gln Glu Ser
                  40                  45                  50

 ttc acg cct act gag gag cat gtg ttg gtg gtg cgc ctg ctg ctg aag      608
 Phe Thr Pro Thr Glu Glu His Val Leu Val Val Arg Leu Leu Leu Lys
              55                  60                  65

 cac ctg cac gcc ttt gcc aac agc ctg aag cca gag cag gcc tca ccc      656
 His Leu His Ala Phe Ala Asn Ser Leu Lys Pro Glu Gln Ala Ser Pro
          70                  75                  80

 tcc gcc cac tcc cac gcc acc agc ccc ctg gag gag ttc aaa cga atg      704
 Ser Ala His Ser His Ala Thr Ser Pro Leu Glu Glu Phe Lys Arg Met
      85                  90                  95

 ggg ctg aac ctc ccg gag gtg ccc agt gct ctc ccc cgg cgg agc caa      752
 Gly Leu Asn Leu Pro Glu Val Pro Ser Ala Leu Pro Arg Arg Ser Gln
 100                 105                 110                 115

 ccc tca ctg atg gga gcc ctg ggg tca tct gtg agc agg gcc tcc tta      800
 Pro Ser Leu Met Gly Ala Leu Gly Ser Ser Val Ser Arg Ala Ser Leu
                 120                 125                 130

 ctg ggc aag cag cag gtg acc ctc ccc atc ccc tgc agg gct gct gtc      848
 Leu Gly Lys Gln Gln Val Thr Leu Pro Ile Pro Cys Arg Ala Ala Val
             135                 140                 145

 ccg agg ttc gtc cag cag aaa ctc tac ctc ttc ttg cag cat tgc ttt      896
 Pro Arg Phe Val Gln Gln Lys Leu Tyr Leu Phe Leu Gln His Cys Phe
         150                 155                 160

 ggc cac tgg ccc ctg gac gca tcg ttc aga gct gtc ctg gag atg tgg      944
 Gly His Trp Pro Leu Asp Ala Ser Phe Arg Ala Val Leu Glu Met Trp
     165                 170                 175

 ctg agc tac ctg cag ccg tgg cgg tac gcg cct gac aag cag gct ccg      992
 Leu Ser Tyr Leu Gln Pro Trp Arg Tyr Ala Pro Asp Lys Gln Ala Pro
 180                 185                 190                 195

 ggc agc gac tcc cag ccc cgg tgt gtg tcg gag aaa tgg gca ccc ttt     1040
 Gly Ser Asp Ser Gln Pro Arg Cys Val Ser Glu Lys Trp Ala Pro Phe
                 200                 205                 210

 gtc cag gag aac ctg ctg atg tac acc aag ttg ttt gtg ggc ttt ctg     1088
 Val Gln Glu Asn Leu Leu Met Tyr Thr Lys Leu Phe Val Gly Phe Leu
             215                 220                 225

 aac cgc gcg ctc cgc aca gac ctg gtc agc ccc aag cac gcg ctc atg     1136
 Asn Arg Ala Leu Arg Thr Asp Leu Val Ser Pro Lys His Ala Leu Met
         230                 235                 240

 gtg ttc cga gtg gcc aaa gtc ttt gcc cag ccc aac ctg gct gag atg     1184
 Val Phe Arg Val Ala Lys Val Phe Ala Gln Pro Asn Leu Ala Glu Met
     245                 250                 255

 att cag aaa ggt gag cag cta ttc ctg gag cca gag ctg gtc atc ccc     1232
 Ile Gln Lys Gly Glu Gln Leu Phe Leu Glu Pro Glu Leu Val Ile Pro
 260                 265                 270                 275

 cac cgc cag cac cga ctc ttc acg gcc ccc aca ttc act ggg agc ttc     1280
 His Arg Gln His Arg Leu Phe Thr Ala Pro Thr Phe Thr Gly Ser Phe
                 280                 285                 290

 ctg tca ccc tgg cca cca gcg gtc act gat gcc tcc ttc aag gtg aag     1328
 Leu Ser Pro Trp Pro Pro Ala Val Thr Asp Ala Ser Phe Lys Val Lys
             295                 300                 305

 agc cac gtc tac agc ctg gag ggc cag gac tgc aag tac acc ccg atg     1376
 Ser His Val Tyr Ser Leu Glu Gly Gln Asp Cys Lys Tyr Thr Pro Met
         310                 315                 320

 ttt ggg ccc gag gcc cgc acc ctg gtc ctg cgc ctc gct cag ctc atc     1424
 Phe Gly Pro Glu Ala Arg Thr Leu Val Leu Arg Leu Ala Gln Leu Ile
     325                 330                 335

 aca cag gcc aaa cac aca gcc aag tcc atc tcc gac cag tgt gcg gag     1472
 Thr Gln Ala Lys His Thr Ala Lys Ser Ile Ser Asp Gln Cys Ala Glu
 340                 345                 350                 355

 agc ccg gct ggc cac tcc ttc ctc tca tgg ctg ggc ttt agc tcc atg     1520
 Ser Pro Ala Gly His Ser Phe Leu Ser Trp Leu Gly Phe Ser Ser Met
                 360                 365                 370

 gac acc aat ggc tcc tac aca gcc aac gac ctg gac gag atg ggg caa     1568
 Asp Thr Asn Gly Ser Tyr Thr Ala Asn Asp Leu Asp Glu Met Gly Gln
             375                 380                 385

 gac agt gtc cgg aag aca gat gaa tac ctg gag aag gcc ctg gag tac     1616
 Asp Ser Val Arg Lys Thr Asp Glu Tyr Leu Glu Lys Ala Leu Glu Tyr
         390                 395                 400

 ctg cgc cag ata ttc cgg ctc agc gaa gcg cag ctc agg cag ttc aca     1664
 Leu Arg Gln Ile Phe Arg Leu Ser Glu Ala Gln Leu Arg Gln Phe Thr
     405                 410                 415

 ctc gcc ttg ggc acc acc cag gat gag aat gga aaa aag caa ctc ccc     1712
 Leu Ala Leu Gly Thr Thr Gln Asp Glu Asn Gly Lys Lys Gln Leu Pro
 420                 425                 430                 435

 gac tgc atc gtg ggt gag gac gga ctc atc ctt acg ccc ctg ggg cgg     1760
 Asp Cys Ile Val Gly Glu Asp Gly Leu Ile Leu Thr Pro Leu Gly Arg
                 440                 445                 450

 tac cag atc atc aat ggg ctg cga agg ttt gaa att gag tac cag ggg     1808
 Tyr Gln Ile Ile Asn Gly Leu Arg Arg Phe Glu Ile Glu Tyr Gln Gly
             455                 460                 465

 gac ccg aag ctg cag ccc atc cgg agc tat gag atc gcc agc ttg gtc     1856
 Asp Pro Lys Leu Gln Pro Ile Arg Ser Tyr Glu Ile Ala Ser Leu Val
         470                 475                 480

 cgc aca ctc ttt agg ctg tcg tct gcc atc aac cac aga ttt gca gga     1904
 Arg Thr Leu Phe Arg Leu Ser Ser Ala Ile Asn His Arg Phe Ala Gly
     485                 490                 495

 cag atg gcg gct ctg tgt tcc cgg gat gac ttc ctc ggc agc ttc tgt     1952
 Gln Met Ala Ala Leu Cys Ser Arg Asp Asp Phe Leu Gly Ser Phe Cys
 500                 505                 510                 515

 cgc tac cac ctc aca gaa cct ggg ctg gcc agc agg cac ctg ctg agc     2000
 Arg Tyr His Leu Thr Glu Pro Gly Leu Ala Ser Arg His Leu Leu Ser
                 520                 525                 530

 cct gtg ggg cgg agg cag gtg gcc ggc cac acc cgc ggc ccc agg ctc     2048
 Pro Val Gly Arg Arg Gln Val Ala Gly His Thr Arg Gly Pro Arg Leu
             535                 540                 545

 agc ctg cgc ttc ctg ggc agt tac cgg acg ctg gtc tcg ctg ctg ctg     2096
 Ser Leu Arg Phe Leu Gly Ser Tyr Arg Thr Leu Val Ser Leu Leu Leu
         550                 555                 560

 gcc ttc ttc gtg gcc tct ctg ttc tgc gtc ggg ccc ctc cca tgc acg     2144
 Ala Phe Phe Val Ala Ser Leu Phe Cys Val Gly Pro Leu Pro Cys Thr
     565                 570                 575

 ctg ctg ctc acc ctg ggc tat gtc ctc tac gcc tct gcc atg aca ctg     2192
 Leu Leu Leu Thr Leu Gly Tyr Val Leu Tyr Ala Ser Ala Met Thr Leu
 580                 585                 590                 595

 ctg acc gag cgg ggg aag ctg cac cag ccc tga aggtgtca gctgccttca     2243
 Leu Thr Glu Arg Gly Lys Leu His Gln Pro 
                 600                 605

 gagcaggctg gagggatttg ccacacagcc ccacccttgg gctgagagga cctgggaagc   2303

 ccctccagga gggaacacgg tcatcctcgg gcttctggag cggggttcct gcagccgcag   2363

 aggcatctgg aggaaacgca accaagaaag gaaggcaggt gggccccagc aaaggagtag   2423

 ctgccagggc tcaacagcta cgctctgtga cagcgcagag ctcagcgccg gcctttccct   2483

 ccctccgcca aggactcacg gccaagccag ctctcggggc cttttttcca gtgcccattt   2543

 ggctactctg ctgcaccaag cttgggagcc agcctgccaa cagccacctg ggcctggcct   2603

 ccccactggc tggccttgag gttggcagag tgggttgtgg cgcttcctct ctctgtgtgg   2663

 gaccaggaca gtggcttaag tctccactcc aggaaagaat caaagtttct agagttgtga   2723

 gaaaaccaga gagtggctgt cctgattctt cactgtgagg ggcgttcttc atgttctccc   2783

 agctgttcca agactgggcc gtagaattcc atgtttcagg agcctaagac cctcccagag   2843

 cccaggggct tcaccgcaga ccccaagcca ttgagcacat cacccaaagc agtggccaac   2903

 atcgcggacc cctgtgcctt gtcacagatg ggtgctggtc ctcaggcgtt ggggacactg   2963

 ctgggtcgat ggggtcggat tctgccagtt tctgctctgc agccaaagat ggtcagaagc   3023

 attgtcactt cagtaacatc aagtgctcaa agacatggca accgttcagt ggtacttaag   3083

 tattcaaaat atacaactac agattctctg acagaaacca gcacggggtc ttcaccttca   3143

 ttcaccccac aggcgacatg cgagggagaa cagcatctca gtggtgattt ccaaaccaag   3203

 cctttgtttt cggtgtgggg ttttgggggt ttgctttaat gtttttgaaa ttgtaaatgt   3263

 tgggcttttt attttgatgt aaactgagaa taatggcatt ttagggcctg tgaccaaaaa   3323

 tgaagcttgt aacgaccatg gatctgaata aacatgtcct tgcttctgaa aaaaaaaaaa   3383




      <210> 103
      <211> 1286
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (521)..(1264)

      <400> 103
 gtgcggcttt cgccgcgcta ttgcttgcca gctttccaga gtgttgaatc ttccaccaga     60

 aaacttgatc acatcaatat ctgcagttcc aatttcccaa aaagaagaag tagctgattt    120

 tcagctttct gtggattctt tattggaaaa agacaatgac cattcaagac cagatattca    180

 agttcaagcc aagagactag cagagaagct aagatgtgat acagtggtga gtgaaatcag    240

 tactggtcaa aggactgtaa atttcaaaat aaacagagag ctcttaacaa agacagtgct    300

 acaacaagta attgaagatg gctcaaaata tggattaaaa agtgaacttt tctctggact    360

 tccccagaag aagattgtgg ttgaattcag ttcacctaat gttgccaaaa aatttcatgt    420

 tggacatttg cgttctacca tcataggaaa ttttatagca aatctcaaag aagctttagg    480

 acatcaagta ataagaataa attaccttgg cgattggggc  atg cag ttt ggt ctt     535
                                              Met Gln Phe Gly Leu
                                                1               5

 ctg gga act ggc ttc cag ctg ttt ggc tat gag gaa aaa ctg cag tcc      583
 Leu Gly Thr Gly Phe Gln Leu Phe Gly Tyr Glu Glu Lys Leu Gln Ser
                  10                  15                  20

 aat cct cta cag cat ctc ttt gaa gtt tat gta caa gtt aat aaa gaa      631
 Asn Pro Leu Gln His Leu Phe Glu Val Tyr Val Gln Val Asn Lys Glu
              25                  30                  35

 gca gca gat gat aaa agt gta gca aaa gca gca cag gag ttc ttc caa      679
 Ala Ala Asp Asp Lys Ser Val Ala Lys Ala Ala Gln Glu Phe Phe Gln
          40                  45                  50

 cga ttg gaa ctg ggc gat gtg caa gca ctt tca ctg tgg caa aaa ttt      727
 Arg Leu Glu Leu Gly Asp Val Gln Ala Leu Ser Leu Trp Gln Lys Phe
      55                  60                  65

 cgg gac ttg agc att gaa gag tac att cgg gtt tac aag cgt ctg gga      775
 Arg Asp Leu Ser Ile Glu Glu Tyr Ile Arg Val Tyr Lys Arg Leu Gly
  70                  75                  80                  85

 gta tat ttt gat gaa tat tca gga gaa tca ttt tat cgt gaa aaa tct      823
 Val Tyr Phe Asp Glu Tyr Ser Gly Glu Ser Phe Tyr Arg Glu Lys Ser
                  90                  95                 100

 caa gag gtc tta aag ttg ctg gag agt aaa gga ctc cta ctg aaa aca      871
 Gln Glu Val Leu Lys Leu Leu Glu Ser Lys Gly Leu Leu Leu Lys Thr
             105                 110                 115

 ata aaa gga acg gct gta gta gat ctc tct ggg aat ggc gac ccc tcc      919
 Ile Lys Gly Thr Ala Val Val Asp Leu Ser Gly Asn Gly Asp Pro Ser
         120                 125                 130

 tca att tgt act gta atg cga agt gat ggg act tct ctc tat gca acc      967
 Ser Ile Cys Thr Val Met Arg Ser Asp Gly Thr Ser Leu Tyr Ala Thr
     135                 140                 145

 aga gat ctt gca gct gct ata gat cga atg gac aag tat aat ttt gat     1015
 Arg Asp Leu Ala Ala Ala Ile Asp Arg Met Asp Lys Tyr Asn Phe Asp
 150                 155                 160                 165

 aca atg ata tat gtg aca gat aaa gga caa aaa aag cat ttt cag caa     1063
 Thr Met Ile Tyr Val Thr Asp Lys Gly Gln Lys Lys His Phe Gln Gln
                 170                 175                 180

 gta ttc caa atg ctg aag atc atg gga tat gac tgg gca gaa agg tgc     1111
 Val Phe Gln Met Leu Lys Ile Met Gly Tyr Asp Trp Ala Glu Arg Cys
             185                 190                 195

 cag cac gtg ccc ttt gga gta gta cag gga atg aag act cga aga gga     1159
 Gln His Val Pro Phe Gly Val Val Gln Gly Met Lys Thr Arg Arg Gly
         200                 205                 210

 gat gtc act ttc ctg gaa gat gtt tta aat gag att caa tta agg atg     1207
 Asp Val Thr Phe Leu Glu Asp Val Leu Asn Glu Ile Gln Leu Arg Met
     215                 220                 225

 cta cag aac atg gct tca att aag agt gaa ttc agt ttt ttc tta tta     1255
 Leu Gln Asn Met Ala Ser Ile Lys Ser Glu Phe Ser Phe Phe Leu Leu
 230                 235                 240                 245

 aag tca taa cttacgtgcc aaaaaaaaaa aa                                1286
 Lys Ser 






      <210> 104
      <211> 1772
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (521)..(1732)

      <400> 104
 gtgcggcttt cgccgcgcta ttgcttgcca gctttccaga gtgttgaatc ttccaccaga     60

 aaacttgatc acatcaatat ctgcagttcc aatttcccaa aaagaagaag tagctgattt    120

 tcagctttct gtggattctt tattggaaaa agacaatgac cattcaagac cagatattca    180

 agttcaagcc aagagactag cagagaagct aagatgtgat acagtggtga gtgaaatcag    240

 tactggtcaa aggactgtaa atttcaaaat aaacagagag ctcttaacaa agacagtgct    300

 acaacaagta attgaagatg gctcaaaata tggattaaaa agtgaacttt tctctggact    360

 tccccagaag aagattgtgg ttgaattcag ttcacctaat gttgccaaaa aatttcatgt    420

 tggacatttg cgttctacca tcataggaaa ttttatagca aatctcaaag aagctttagg    480

 acatcaagta ataagaataa attaccttgg cgattggggc  atg cag ttt ggt ctt     535
                                              Met Gln Phe Gly Leu
                                                1               5

 ctg gga act ggc ttc cag ctg ttt ggc tat gag gaa aaa ctg cag tcc      583
 Leu Gly Thr Gly Phe Gln Leu Phe Gly Tyr Glu Glu Lys Leu Gln Ser
                  10                  15                  20

 aat cct cta cag cat ctc ttt gaa gtt tat gta caa gtt aat aaa gaa      631
 Asn Pro Leu Gln His Leu Phe Glu Val Tyr Val Gln Val Asn Lys Glu
              25                  30                  35

 gca gca gat gat aaa agt gta gca aaa gca gca cag gag ttc ttc caa      679
 Ala Ala Asp Asp Lys Ser Val Ala Lys Ala Ala Gln Glu Phe Phe Gln
          40                  45                  50

 cga ttg gaa ctg ggc gat gtg caa gca ctt tca ctg tgg caa aaa ttt      727
 Arg Leu Glu Leu Gly Asp Val Gln Ala Leu Ser Leu Trp Gln Lys Phe
      55                  60                  65

 cgg gac ttg agc att gaa gag tac att cgg gtt tac aag cgt ctg gga      775
 Arg Asp Leu Ser Ile Glu Glu Tyr Ile Arg Val Tyr Lys Arg Leu Gly
  70                  75                  80                  85

 gta tat ttt gat gaa tat tca gga gaa tca ttt tat cgt gaa aaa tct      823
 Val Tyr Phe Asp Glu Tyr Ser Gly Glu Ser Phe Tyr Arg Glu Lys Ser
                  90                  95                 100

 caa gag gtc tta aag ttg ctg gag agt aaa gga ctc cta ctg aaa aca      871
 Gln Glu Val Leu Lys Leu Leu Glu Ser Lys Gly Leu Leu Leu Lys Thr
             105                 110                 115

 ata aaa gga acg gct gta gta gat ctc tct ggg aat ggc gac ccc tcc      919
 Ile Lys Gly Thr Ala Val Val Asp Leu Ser Gly Asn Gly Asp Pro Ser
         120                 125                 130

 tca att tgt act gta atg cga agt gat ggg act tct ctc tat gca acc      967
 Ser Ile Cys Thr Val Met Arg Ser Asp Gly Thr Ser Leu Tyr Ala Thr
     135                 140                 145

 aga gat ctt gca gct gct ata gat cga atg gac aag tat aat ttt gat     1015
 Arg Asp Leu Ala Ala Ala Ile Asp Arg Met Asp Lys Tyr Asn Phe Asp
 150                 155                 160                 165

 aca atg ata tat gtg aca gat aaa gga caa aaa aag cat ttt cag caa     1063
 Thr Met Ile Tyr Val Thr Asp Lys Gly Gln Lys Lys His Phe Gln Gln
                 170                 175                 180

 gta ttc caa atg ctg aag atc atg gga tat gac tgg gca gaa agg tgc     1111
 Val Phe Gln Met Leu Lys Ile Met Gly Tyr Asp Trp Ala Glu Arg Cys
             185                 190                 195

 cag cac gtg ccc ttt gga gta gta cag gga atg aag act cga aga gga     1159
 Gln His Val Pro Phe Gly Val Val Gln Gly Met Lys Thr Arg Arg Gly
         200                 205                 210

 gat gtc act ttc ctg gaa gat gtt tta aat gag att caa tta agg atg     1207
 Asp Val Thr Phe Leu Glu Asp Val Leu Asn Glu Ile Gln Leu Arg Met
     215                 220                 225

 cta cag aac atg gct tca att aag aca act aaa gaa ctc aag aac cca     1255
 Leu Gln Asn Met Ala Ser Ile Lys Thr Thr Lys Glu Leu Lys Asn Pro
 230                 235                 240                 245

 caa gag act gca gag agg gtc ggg ctc gca gca ctc att att cag gac     1303
 Gln Glu Thr Ala Glu Arg Val Gly Leu Ala Ala Leu Ile Ile Gln Asp
                 250                 255                 260

 ttc aaa ggt tta ctc tta tct gac tac aag ttc agc tgg gat cgt gtt     1351
 Phe Lys Gly Leu Leu Leu Ser Asp Tyr Lys Phe Ser Trp Asp Arg Val
             265                 270                 275

 ttc cag agt cgc ggg gac aca gga gtc ttc cta cag tac aca cac gcc     1399
 Phe Gln Ser Arg Gly Asp Thr Gly Val Phe Leu Gln Tyr Thr His Ala
         280                 285                 290

 cgc ctc cac agt ttg gaa gag act ttt gga tgt ggg tac ctg aat gac     1447
 Arg Leu His Ser Leu Glu Glu Thr Phe Gly Cys Gly Tyr Leu Asn Asp
     295                 300                 305

 ttc aac act gct tgt tta caa gag cca cag tct gtt tca att ctt cag     1495
 Phe Asn Thr Ala Cys Leu Gln Glu Pro Gln Ser Val Ser Ile Leu Gln
 310                 315                 320                 325

 cat ctt ctc agg ttc gac gag gtg ctt tat aaa tca tct cag gac ttt     1543
 His Leu Leu Arg Phe Asp Glu Val Leu Tyr Lys Ser Ser Gln Asp Phe
                 330                 335                 340

 caa ccc agg cat atc gtc agt tac ctt cta act tta agt cat ctt gca     1591
 Gln Pro Arg His Ile Val Ser Tyr Leu Leu Thr Leu Ser His Leu Ala
             345                 350                 355

 gct gtg gca cac aaa aca cta caa ata aaa gat agt cct cct gaa gtg     1639
 Ala Val Ala His Lys Thr Leu Gln Ile Lys Asp Ser Pro Pro Glu Val
         360                 365                 370

 gct ggg gcc aga ctt cat ctt ttc aaa gct gtc cgt tct gtc cta gcc     1687
 Ala Gly Ala Arg Leu His Leu Phe Lys Ala Val Arg Ser Val Leu Ala
     375                 380                 385

 aat gga atg aaa ctt ctt gga ata aca cct gta tgt agg atg taa ttt     1735
 Asn Gly Met Lys Leu Leu Gly Ile Thr Pro Val Cys Arg Met 
 390                 395                 400

 ccattaaaat ggcttttaaa atgtcaaaaa aaaaaaa                            1772




      <210> 105
      <211> 1142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(294)

      <220>
      <221> misc_feature
      <222> (1)...(1142)
      <223> n = a,t,c or g

      <400> 105
 cggcagccct accccttcga gcgc   atg atc ttc ggc gcc tgc gct ggc ctc      51
                              Met Ile Phe Gly Ala Cys Ala Gly Leu
                                1               5

 atc ggg cag tcg gcc tcg tac ccg ctg gat gtg gtg cgg cgg cgc atg       99
 Ile Gly Gln Ser Ala Ser Tyr Pro Leu Asp Val Val Arg Arg Arg Met
  10                  15                  20                  25

 cag acg gcc ggc gtc acg ggc tac ccg cgc gcc tcc atc gcc cgc acg      147
 Gln Thr Ala Gly Val Thr Gly Tyr Pro Arg Ala Ser Ile Ala Arg Thr
                  30                  35                  40

 ctg cgc acc atc gtg cgg gag gag ggc gcc gtg cgc ggc ctc tac aaa      195
 Leu Arg Thr Ile Val Arg Glu Glu Gly Ala Val Arg Gly Leu Tyr Lys
              45                  50                  55

 ggc ttg agc atg aac tgg gtc aag ggt ccc atc gcc gtg ggc atc agc      243
 Gly Leu Ser Met Asn Trp Val Lys Gly Pro Ile Ala Val Gly Ile Ser
          60                  65                  70

 ttc acc acc ttc gac ctc atg cag atc ctg ctg cgg cac ctg cag agc      291
 Phe Thr Thr Phe Asp Leu Met Gln Ile Leu Leu Arg His Leu Gln Ser
      75                  80                  85

 tag ggga ccctgagctg ctctcaggac ggtggaccgg tgaccccttt gtattctggg      348
 


 cccatggaac ggtggggggg tgcgcttgat tctacttcag gaggcacatg gggcgcttta    408

 tggaacgagc aggtgggcct gaggggcctg ggctcagagt ccacgtccaa acgcaaagct    468

 ggcagccctg gaagtgcagt gttggggcga tggtgtgggg ggtcccgcag ctcccctctt    528

 ccttcctctg cagacgctgg cgctgtctgc cggaggtgtt gcccaaaagg ccctagtggg    588

 cgtggtcagc ttcaccttct gatcctgtgt gtcctccgac atgctgctga ttctagtgac    648

 ccctgtcccc accaggctca gagccagact gcgcctggac tttcttgtct gactcacgtg    708

 cctggcccgg ctcaaggtgc cggggcgcct ttcttgcagc gaccctgccc agatggggca    768

 gcctggggct agcttttggc acaatgccag ccctgcccac ccaccctggc ggcctgcctt    828

 ttcagatttt ccaactgccc cgattctaag tactaagcct ctgtgggaca gggcccccaa    888

 gcctatgtat tctaaaccga agaggtgggt cccaaaagct ttcccctaag tcctgccatc    948

 ccattgtttg tactccaaag aatttttgtt tgcacaaggg ttggccagca gaacngaggc   1008

 tnnngttggg gcaaccttgg ggttgtgtga ggngacaaac acttttttgc acaccccaaa   1068

 tatnnccccc cttttnggtt gaannntgtt ccccnnanng ngnttgggga tanaaaaccc   1128

 ngnttnnttt aaaa                                                     1142




      <210> 106
      <211> 1880
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (229)..(1173)

      <400> 106
 gctcccgagc gcaggcgggc agccaggcgg gcggcgcggc gcgggccggc aggaagcgta     60

 ttctgggcac ggggcgccgg gcgggccggc tgcgccgagc gccagtggtg ggataccacc    120

 caaggcctcg cgcggcgccg cccgtcgagg ggcgggcggc ggcgtagcca ctgggccgtc    180

 gaagagcgca ggaggccggt gggccgggcc gggccgcgcg gcgcagcc atg cct ggc     237
                                                      Met Pro Gly
                                                        1

 ttt acg tgc tgc gtg cca ggc tgc tac aac aac tcg cac cgg gac aag      285
 Phe Thr Cys Cys Val Pro Gly Cys Tyr Asn Asn Ser His Arg Asp Lys
       5                  10                  15

 gcg ctg cac ttc tac acg ttt cca aag gac gct gag ttg cgg cgc ctc      333
 Ala Leu His Phe Tyr Thr Phe Pro Lys Asp Ala Glu Leu Arg Arg Leu
  20                  25                  30                  35

 tgg ctc aag aac gtg tcg cgt gcc ggc gtc agt ggg tgc ttc tcc acc      381
 Trp Leu Lys Asn Val Ser Arg Ala Gly Val Ser Gly Cys Phe Ser Thr
                  40                  45                  50

 ttc cag ccc acc aca ggc cac cgt ctc tgc agc gtt cac ttc cag ggc      429
 Phe Gln Pro Thr Thr Gly His Arg Leu Cys Ser Val His Phe Gln Gly
              55                  60                  65

 ggc cgc aag acc tac acg gta cgc gtc ccc acc atc ttc ccg ctg cgc      477
 Gly Arg Lys Thr Tyr Thr Val Arg Val Pro Thr Ile Phe Pro Leu Arg
          70                  75                  80

 ggc gtc aat gag cgc aaa gta gcg cgc aga ccc gct ggg gcc gcg gcc      525
 Gly Val Asn Glu Arg Lys Val Ala Arg Arg Pro Ala Gly Ala Ala Ala
      85                  90                  95

 gcc cgc cgc agg cag cag cag caa cag cag cag cag cag caa cag cag      573
 Ala Arg Arg Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
 100                 105                 110                 115

 caa cag cag cag cag cag caa cag cag cag cag cag cag cag cag cag      621
 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
                 120                 125                 130

 cag tcc tca ccc tct gcc tcc act gcc cag act gcc cag ctg cag ccg      669
 Gln Ser Ser Pro Ser Ala Ser Thr Ala Gln Thr Ala Gln Leu Gln Pro
             135                 140                 145

 aac ctg gta tct gct tcc gcg gcc gtg ctt ctc acc ctt cag gcc act      717
 Asn Leu Val Ser Ala Ser Ala Ala Val Leu Leu Thr Leu Gln Ala Thr
         150                 155                 160

 gta gac agc agt cag gct ccg gga tcc gta cag ccg gcg ccc atc act      765
 Val Asp Ser Ser Gln Ala Pro Gly Ser Val Gln Pro Ala Pro Ile Thr
     165                 170                 175

 ccc act gga gaa gac gtg aag ccc atc gat ctc aca gtg caa gtg gag      813
 Pro Thr Gly Glu Asp Val Lys Pro Ile Asp Leu Thr Val Gln Val Glu
 180                 185                 190                 195

 ttt gca gcc gca gag ggc gca gcc gct gcg gcc gcc gcg tcg gag tta      861
 Phe Ala Ala Ala Glu Gly Ala Ala Ala Ala Ala Ala Ala Ser Glu Leu
                 200                 205                 210

 cag gct gct acc gca ggg ctg gag gct gcc gag tgc cct atg ggc ccc      909
 Gln Ala Ala Thr Ala Gly Leu Glu Ala Ala Glu Cys Pro Met Gly Pro
             215                 220                 225

 cag ttg gtg gtg gta ggg gaa gag ggc ttc cct gat act ggc tcc gac      957
 Gln Leu Val Val Val Gly Glu Glu Gly Phe Pro Asp Thr Gly Ser Asp
         230                 235                 240

 cat tcg tac tcc ttg tcg tca ggc acc acg gag gag gag ctc ctg cgc     1005
 His Ser Tyr Ser Leu Ser Ser Gly Thr Thr Glu Glu Glu Leu Leu Arg
     245                 250                 255

 aag ctg aat gag cag cgg gac atc ctg gct ctg atg gaa gtg aag atg     1053
 Lys Leu Asn Glu Gln Arg Asp Ile Leu Ala Leu Met Glu Val Lys Met
 260                 265                 270                 275

 aaa gag atg aaa ggc agc att cgc cac ctg cgt ctc act gag gcc aag     1101
 Lys Glu Met Lys Gly Ser Ile Arg His Leu Arg Leu Thr Glu Ala Lys
                 280                 285                 290

 ctg cgc gaa gaa ctg cgt gag aag gat cgg ctg ctt gcc atg gct gtc     1149
 Leu Arg Glu Glu Leu Arg Glu Lys Asp Arg Leu Leu Ala Met Ala Val
             295                 300                 305

 atc cgc aag aag cac gga atg tga actggtgccc cggcagcctg ctggactccc    1203
 Ile Arg Lys Lys His Gly Met 
         310

 agaccccatc cagccagggg accgcaggcc attgttgaac tcctctatac tcctgggcac   1263

 tggttgacag tactgaggct taaggcagct ggactctctt gctggtgacc tggcatcctc   1323

 aattgtttcc tcctgaagtg gaagctgggg ccttagactc tgccctggtg acaccagcaa   1383

 ttatgacttt gtctaccctt cctccccagt tattgttgca gattctggtt aagcagaggc   1443

 ttcagaacca ctgaacttga aacttaccct ctagggatgc aggtgggatg tccagggact   1503

 ataggtttgg gaaaaccata ccttaaggtt ggtcagcagt cagacaactc taatgtgtgt   1563

 agtgataaga gattcaagta acatcagttc tcctcctttt catgcttttc cttcccaggt   1623

 gcagcctgtg attctgatgg ggactggtaa atctgtgcct ctgcctccta ggacttattt   1683

 tcccaggagg ccatttacaa ggggatctgg atgacctgct gatggagatc cagcttgcca   1743

 gggacttagg tttatcctgt tttgtttgct actggttaca aattctattt tctgtacaat   1803

 tagtcagact aaagttttca ctgtgtttgt ttggcaaaac aaattaaaca aaaagtaagg   1863

 tttttaaaaa aaaaaaa                                                  1880




      <210> 107
      <211> 483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(433)

      <400> 107
 agaacagctg ctgcttgctg tacgtggtgg aggaccagct gtgtgatgtg gagcaagcct     60

 tcagagctga gcatttgggc caacaccaga gtggttcggg aacagg   atg cag aca     115
                                                      Met Gln Thr
                                                        1

 ttg tcc tca acg acc agc ggc act ttg atc cgg ttt tcc agt tct tgc      163
 Leu Ser Ser Thr Thr Ser Gly Thr Leu Ile Arg Phe Ser Ser Ser Cys
       5                  10                  15

 aca agc aag ttt gtg tca gcc acg ccc tgg gga gga tcc act gga tca      211
 Thr Ser Lys Phe Val Ser Ala Thr Pro Trp Gly Gly Ser Thr Gly Ser
  20                  25                  30                  35

 ccg ccg tca ctg cct gtt ccc ggc ggc ctc tcc ggc ttc cct aaa gag      259
 Pro Pro Ser Leu Pro Val Pro Gly Gly Leu Ser Gly Phe Pro Lys Glu
                  40                  45                  50

 agc agc ttc cct cga gac cag aag cca gag ctc acc ctc cct tgt gtc      307
 Ser Ser Phe Pro Arg Asp Gln Lys Pro Glu Leu Thr Leu Pro Cys Val
              55                  60                  65

 cag gtg gga ctt tct aca acg ctg ctg tgc acg acg tgg atg ccg tat      355
 Gln Val Gly Leu Ser Thr Thr Leu Leu Cys Thr Thr Trp Met Pro Tyr
          70                  75                  80

 gca tgt tgc tgg ggg aag cca ctc cgg aca ctg tgt ttt ctc tgg gac      403
 Ala Cys Cys Trp Gly Lys Pro Leu Arg Thr Leu Cys Phe Leu Trp Asp
      85                  90                  95

 atg tct tct gcc cag ata tgg ccg cct taa a agatgcagat gctgttgtga      454
 Met Ser Ser Ala Gln Ile Trp Pro Pro 
 100                 105

 tcagcatgaa gtttccctgt gaggccgtg                                      483




      <210> 108
      <211> 1587
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(955)

      <400> 108
 ggtcgcgtcc gggttgtcac tctctcgggt tgttactctg tagcttcccg gctcgcgaaa     60

 gggaggacct gtctgggtc atg gat ttt gag aat ctt ttc tca aaa ccc ccc     112
                      Met Asp Phe Glu Asn Leu Phe Ser Lys Pro Pro
                        1               5                  10

 aac ccg gcc ctc ggc aaa acg gcc acg gac tct gac gaa aga atc gat      160
 Asn Pro Ala Leu Gly Lys Thr Ala Thr Asp Ser Asp Glu Arg Ile Asp
              15                  20                  25

 gat gaa ata gat aca gaa gtt gaa gaa aca caa gaa gag aaa att aaa      208
 Asp Glu Ile Asp Thr Glu Val Glu Glu Thr Gln Glu Glu Lys Ile Lys
          30                  35                  40

 ctg gag tgc gag caa att ccc aaa aaa ttt aga cac tct gca ata tca      256
 Leu Glu Cys Glu Gln Ile Pro Lys Lys Phe Arg His Ser Ala Ile Ser
      45                  50                  55

 cca aaa agt tcg ctg cat aga aaa tca aga agt aag gac tat gat gta      304
 Pro Lys Ser Ser Leu His Arg Lys Ser Arg Ser Lys Asp Tyr Asp Val
  60                  65                  70                  75

 tat agt gat aat gat atc tgc agt cag gaa tca gaa gat aat ttt gcc      352
 Tyr Ser Asp Asn Asp Ile Cys Ser Gln Glu Ser Glu Asp Asn Phe Ala
                  80                  85                  90

 aaa gag ctt caa cag tac ata caa gcc aga gaa atg gca aat gct gct      400
 Lys Glu Leu Gln Gln Tyr Ile Gln Ala Arg Glu Met Ala Asn Ala Ala
              95                 100                 105

 caa cct gaa gaa tct aca aag aaa gaa gga gta aaa gat acc cca cag      448
 Gln Pro Glu Glu Ser Thr Lys Lys Glu Gly Val Lys Asp Thr Pro Gln
         110                 115                 120

 gct gct aaa caa aaa aat aaa aat ctt aaa gct ggt cac aag aat ggc      496
 Ala Ala Lys Gln Lys Asn Lys Asn Leu Lys Ala Gly His Lys Asn Gly
     125                 130                 135

 aaa cag aag aaa atg aag cga aaa tgg cct ggc cct gga aac aaa gga      544
 Lys Gln Lys Lys Met Lys Arg Lys Trp Pro Gly Pro Gly Asn Lys Gly
 140                 145                 150                 155

 tca aat gct ttg ctg agg aac agc ggc tca cag gaa gag gat ggt aaa      592
 Ser Asn Ala Leu Leu Arg Asn Ser Gly Ser Gln Glu Glu Asp Gly Lys
                 160                 165                 170

 cct aaa gag aag cag cag cat ttg agt cag gca ttc atc aac caa cat      640
 Pro Lys Glu Lys Gln Gln His Leu Ser Gln Ala Phe Ile Asn Gln His
             175                 180                 185

 aca gtg gaa cgc aag gga aaa caa att tgt aaa tat ttt ctt gaa agg      688
 Thr Val Glu Arg Lys Gly Lys Gln Ile Cys Lys Tyr Phe Leu Glu Arg
         190                 195                 200

 aaa tgt att aag gga gac cag tgt aaa ttt gat cat gat gca gag ata      736
 Lys Cys Ile Lys Gly Asp Gln Cys Lys Phe Asp His Asp Ala Glu Ile
     205                 210                 215

 gaa aag aaa aag gaa atg tgt aag ttt tat gta caa gga tat tgt acc      784
 Glu Lys Lys Lys Glu Met Cys Lys Phe Tyr Val Gln Gly Tyr Cys Thr
 220                 225                 230                 235

 aga ggt gaa aac tgt ctg tat ttg cat aat gaa tat cct tgt aag ttt      832
 Arg Gly Glu Asn Cys Leu Tyr Leu His Asn Glu Tyr Pro Cys Lys Phe
                 240                 245                 250

 tac cat aca gga aca aaa tgt tat cag gga gaa tac tgc aag ttt tct      880
 Tyr His Thr Gly Thr Lys Cys Tyr Gln Gly Glu Tyr Cys Lys Phe Ser
             255                 260                 265

 cat gct cca ctg act cct gaa aca caa gaa ttg ttg gct aaa gtt ttg      928
 His Ala Pro Leu Thr Pro Glu Thr Gln Glu Leu Leu Ala Lys Val Leu
         270                 275                 280

 gat act gaa aag aag tca tgt aaa taa aatag acataaaaag gtagcaatgt      980
 Asp Thr Glu Lys Lys Ser Cys Lys 
     285                 290

 acagataaag agtactttaa cgcccatgcg tgttcaagac tgttcaagac tggtgatttg   1040

 gagtagttta caagattcct cattcagagt gccctcttgt gtgactgggg tgatgtgcag   1100

 cttccataat ggatgggaca gagagctggg atctaatgta caagtgaagg gcttggtctt   1160

 ccctgagaca ttccagccat tggaatagga gaggagcata tatggcagag gtgatggctg   1220

 gtgggtaaat gtgatagtaa attgtagaaa cctcttctga ttgattggat ttccttaata   1280

 aaatcggaag caaggttagg ctgagtgagg gtgagtaaag aggtagagga ggtttgagga   1340

 gagagaactg ctcggaagac attggtagat ggaccataaa aacagagtta gttctcttta   1400

 tgacattaaa tagttttaca acatattttt aatggttcac aatttcattt tagggcttaa   1460

 aataaattat ggttctatga tttttttaaa ccagtttcct attgttagac atttgtttcc   1520

 agtttcttac tattataaat aaagtgaaac aatatctctt actataccat ttctaaaaaa   1580

 aaaaaaa                                                             1587




      <210> 109
      <211> 5002
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1865)

      <220>
      <221> misc_feature
      <222> (1)...(5002)
      <223> n = a,t,c or g

      <400> 109
 aaacagaggt cattnantct ttggnaatta ttatttataa agcactggac tatggtttga     60

 aggagaatga agaaagggaa ttaagccctc ccctagagca gcttatcgat cac   atg     116
                                                              Met
                                                                1

 gcc aac acg gtg gaa gct gac ggt agc aat gat gag ggc tat gag gct      164
 Ala Asn Thr Val Glu Ala Asp Gly Ser Asn Asp Glu Gly Tyr Glu Ala
               5                  10                  15

 gca gaa gaa ggc ctg gga gat gaa gat gaa aag aga aaa atc tca gct      212
 Ala Glu Glu Gly Leu Gly Asp Glu Asp Glu Lys Arg Lys Ile Ser Ala
          20                  25                  30

 att cgg tca tat aga gat gtc atg aag ttg tgt gct gct cat ctc cct      260
 Ile Arg Ser Tyr Arg Asp Val Met Lys Leu Cys Ala Ala His Leu Pro
      35                  40                  45

 act gaa tca gat gca cca aat cat tat cag gca gta tgt cgt gca ctg      308
 Thr Glu Ser Asp Ala Pro Asn His Tyr Gln Ala Val Cys Arg Ala Leu
  50                  55                  60                  65

 ttt gca gaa aca atg gag ctc cat aca ttt ctg acc aaa att aag agt      356
 Phe Ala Glu Thr Met Glu Leu His Thr Phe Leu Thr Lys Ile Lys Ser
                  70                  75                  80

 gcg aaa gag aat ctt aag aag att caa gaa atg gaa aag agc gat gaa      404
 Ala Lys Glu Asn Leu Lys Lys Ile Gln Glu Met Glu Lys Ser Asp Glu
              85                  90                  95

 tct agc aca gac ttg gaa gag ctg aaa aac gct gac tgg gca cga ttc      452
 Ser Ser Thr Asp Leu Glu Glu Leu Lys Asn Ala Asp Trp Ala Arg Phe
         100                 105                 110

 tgg gta cag gtg atg agg gat ttg agg aat ggg gta aaa ctt aag aag      500
 Trp Val Gln Val Met Arg Asp Leu Arg Asn Gly Val Lys Leu Lys Lys
     115                 120                 125

 gtc caa gag cgg cag tac aac cct ttg ccc att gaa tat cag ctc acc      548
 Val Gln Glu Arg Gln Tyr Asn Pro Leu Pro Ile Glu Tyr Gln Leu Thr
 130                 135                 140                 145

 cct tat gag atg tta atg gat gac att cgc tgc aaa aga tac acc ttg      596
 Pro Tyr Glu Met Leu Met Asp Asp Ile Arg Cys Lys Arg Tyr Thr Leu
                 150                 155                 160

 cga aaa gtg atg gtg aat ggt gat att ccc cct cgg tta aaa aag agt      644
 Arg Lys Val Met Val Asn Gly Asp Ile Pro Pro Arg Leu Lys Lys Ser
             165                 170                 175

 gct cat gaa atc atc ctc gac ttc atc aga tcc aga cct cct tta aat      692
 Ala His Glu Ile Ile Leu Asp Phe Ile Arg Ser Arg Pro Pro Leu Asn
         180                 185                 190

 cca gtc tca gcc aga aaa ctg aaa cca act cca cca cgg cca cgg agc      740
 Pro Val Ser Ala Arg Lys Leu Lys Pro Thr Pro Pro Arg Pro Arg Ser
     195                 200                 205

 ctc cat gaa aga ata tta gaa gaa att aaa gca gaa aga aag ctg cgg      788
 Leu His Glu Arg Ile Leu Glu Glu Ile Lys Ala Glu Arg Lys Leu Arg
 210                 215                 220                 225

 cct gta tca cca gag gag att aga cgt agc aga tta gat gtg act acc      836
 Pro Val Ser Pro Glu Glu Ile Arg Arg Ser Arg Leu Asp Val Thr Thr
                 230                 235                 240

 cct gaa tct aca aag aat ctt gtg gag tca tct atg gtg aat gga ggt      884
 Pro Glu Ser Thr Lys Asn Leu Val Glu Ser Ser Met Val Asn Gly Gly
             245                 250                 255

 ttg aca tca caa aca aaa gaa aac ggg tta agt acc tca cag cag gtg      932
 Leu Thr Ser Gln Thr Lys Glu Asn Gly Leu Ser Thr Ser Gln Gln Val
         260                 265                 270

 cct gca cag cgg aag aag ctc ctc aga gcc cca act ctg gcc gaa ctg      980
 Pro Ala Gln Arg Lys Lys Leu Leu Arg Ala Pro Thr Leu Ala Glu Leu
     275                 280                 285

 gac agc tct gag tct gag gaa gaa acg ctg cac aag tcg acc agc agc     1028
 Asp Ser Ser Glu Ser Glu Glu Glu Thr Leu His Lys Ser Thr Ser Ser
 290                 295                 300                 305

 agc agc gtg tct ccc tct ttc cct gaa gag cca gtc ctg gag gcc gtg     1076
 Ser Ser Val Ser Pro Ser Phe Pro Glu Glu Pro Val Leu Glu Ala Val
                 310                 315                 320

 tcc aca agg aag aag cct cca aaa ttc ctg ccc ata tca tca aca ccc     1124
 Ser Thr Arg Lys Lys Pro Pro Lys Phe Leu Pro Ile Ser Ser Thr Pro
             325                 330                 335

 cag cca gag aga cgg cag cca ccc cag aga cga cat tcc att gaa aag     1172
 Gln Pro Glu Arg Arg Gln Pro Pro Gln Arg Arg His Ser Ile Glu Lys
         340                 345                 350

 gaa acg cct act aac gtg agg cag ttc ctg ccg cct tcc agg cag agt     1220
 Glu Thr Pro Thr Asn Val Arg Gln Phe Leu Pro Pro Ser Arg Gln Ser
     355                 360                 365

 tcc cgc tct ctt gag gaa ttc tgc tac cca gtg gaa tgc ctc gct ctt     1268
 Ser Arg Ser Leu Glu Glu Phe Cys Tyr Pro Val Glu Cys Leu Ala Leu
 370                 375                 380                 385

 act gtg gaa gaa gtg atg cat att cgc cag gtc ctg gtg aag gca gag     1316
 Thr Val Glu Glu Val Met His Ile Arg Gln Val Leu Val Lys Ala Glu
                 390                 395                 400

 ctg gaa aaa tac caa cag tat aaa gac atc tac acc gcc ttg aaa aaa     1364
 Leu Glu Lys Tyr Gln Gln Tyr Lys Asp Ile Tyr Thr Ala Leu Lys Lys
             405                 410                 415

 gga aag ctc tgc ttt tgt tgc cga acc agg agg ttt tcc ttc ttc act     1412
 Gly Lys Leu Cys Phe Cys Cys Arg Thr Arg Arg Phe Ser Phe Phe Thr
         420                 425                 430

 tgg tct tat acc tgt cag ttc tgt aag agg ccg gtg tgc tca cag tgt     1460
 Trp Ser Tyr Thr Cys Gln Phe Cys Lys Arg Pro Val Cys Ser Gln Cys
     435                 440                 445

 tgc aaa aag atg cgg ctg ccc tcc aaa cca tac tcc act ctt cct atc     1508
 Cys Lys Lys Met Arg Leu Pro Ser Lys Pro Tyr Ser Thr Leu Pro Ile
 450                 455                 460                 465

 ttt tca ttg gga cct tct gct ctg caa aga ggg gaa agt agt atg agg     1556
 Phe Ser Leu Gly Pro Ser Ala Leu Gln Arg Gly Glu Ser Ser Met Arg
                 470                 475                 480

 tca gaa aaa ccc tcc act gcc cat cat cgg cca ctt cgg agc att gcc     1604
 Ser Glu Lys Pro Ser Thr Ala His His Arg Pro Leu Arg Ser Ile Ala
             485                 490                 495

 agg ttc tcc tca aaa tct aag tct atg gac aaa tca gat gaa gaa ctc     1652
 Arg Phe Ser Ser Lys Ser Lys Ser Met Asp Lys Ser Asp Glu Glu Leu
         500                 505                 510

 cag ttt ccc aaa gag ttg atg gag gac tgg agc acc atg gag gtg tgt     1700
 Gln Phe Pro Lys Glu Leu Met Glu Asp Trp Ser Thr Met Glu Val Cys
     515                 520                 525

 gtg gac tgc aag aag ttc att tcg gaa atc atc agt tca agc cgg cgc     1748
 Val Asp Cys Lys Lys Phe Ile Ser Glu Ile Ile Ser Ser Ser Arg Arg
 530                 535                 540                 545

 agt ctg gtg ttg gcc aac aaa agg gcc cga ttg aaa agg aaa acg cag     1796
 Ser Leu Val Leu Ala Asn Lys Arg Ala Arg Leu Lys Arg Lys Thr Gln
                 550                 555                 560

 tct ttc tac atg tcc tcg cca ggc ccc tcg gag tac tgc cct tca gag     1844
 Ser Phe Tyr Met Ser Ser Pro Gly Pro Ser Glu Tyr Cys Pro Ser Glu
             565                 570                 575

 agg acg atc agt gag atc tga gc ctcgtgcctt tcagctgctt ttgtgctacg     1897
 Arg Thr Ile Ser Glu Ile 
         580

 agtcagcgtc cgtgcgcgag gacactgagc cgggctggct ctcctttctg tggttttatt   1957

 taatgggctt gaatttgcat tagatcagat ttttgccgca tcacattgtt ccacagactg   2017

 aatgctgtgt tcgtatcgat tgatgaaacg tgacaggtcc gccaattgct cgtttgcact   2077

 gagagaggac aacagtttga aacttacttt tgtgtgtgtg tggctttgga agccagtagc   2137

 tacttcctta gttcagttct ttactgttcc tcgaataatc tcctgactaa ggcaaaaaaa   2197

 aaaagcttct cctacgagaa tcagtctaac agagatgccg atgtcagcac agccctaagc   2257

 agtaagtcat attggcattt ccacgtgact gtgtttctat cccgtgtaca gagagatcca   2317

 gagccctaca ctccacgacc tgggggctca cagcacagaa cctagaagca cctgctgaca   2377

 ctcttcaact gatttttaaa tgttgttgct tggagataaa aattacataa gggacttttt   2437

 gcctgcattc tagtgcaaaa catctgaaga gctgtacacc cacaagggtg actatttccc   2497

 ctgagtggcc gtgttgtccc agtgccctgg ttcagtgtct cctgagtgga tgacaggtct   2557

 tcattctcta tcttgaatgt attatggtta ctaatagttt tataatggag gtctaagaat   2617

 taaagttgtg tgggagtttc aggacaaagg aaggctaaaa gtttgtcaag acgttgagcg   2677

 tattttggtt acctatgaga agggttgtga cagtgtacag tggcagctgt tggccacgct   2737

 gcagaaatga gctggagctc atgggttttc agctacattt ttcataactt tgtagtacat   2797

 ccatcttgag taaattaagc cacaatttgg tacctagggt ctcaaactaa aatttatttt   2857

 tataaatgaa ttttaaaaga aaaaatatct acttctttta aagttagaag aaaattaacc   2917

 tgctgacagg caacattttt ggggtgcttt ctgcactagt tttccttgta aatgatttga   2977

 gtgagtaggt ttggtttctg acgaaagtag actggagggt agcattgtat gcctcaaatg   3037

 tctcagtgtg tttggctcat acgtgggcta tactttatta ttttggtatg cttacaaatg   3097

 actaaccaat caaattgtca ttaatgtttg gaaaatctgt taatgcacat gcacaataat   3157

 ttcctgaaag ccataggaca tgtctgtagt cagcaccacg atagcaccgt ttcatgaaag   3217

 gcatggcggc tgcatttcat accacatcaa aatacagtaa catttctata ctaaattaac   3277

 agtaatacct caaaactgct ccggtagtag tttttaatgg attgaaattt acagtttagt   3337

 aaaaggctta aaattactta tacttatgaa ataaacttta ccagttgact aaaataatgc   3397

 atgttaacag ttggtctgta tttgcatgta aaagtgggcc accagagaac ccttattgat   3457

 tacttaagtg tttacattat tttaaagact cctgtttaag agctttcaga attgtactgg   3517

 gtgaatctca tttataaaac ttcctaagag actatctgaa ctctatactc cagacagtta   3577

 ggtgggagta taaatctacc ccttttgatg accccaggct tgagttttta aaatgactac   3637

 ccagaagggc acaaggggga aggaaatggt atttgtatat gtatataaat atgcacctag   3697

 gagaatgtgc tttttaaaat aatgactact gtttttatta aaacataaga aactacaccc   3757

 ccaaaataag actttcattc acattcacaa agcaaacatc tagtacatgt ctttcacttc   3817

 actttatgat agtgtattgg atgatttggg cattacgatc acctcttacc acagcacaga   3877

 acatacattc ttcaacagca ttaacggagt ttgccaagtg cattaaagag gtcacgtgga   3937

 gggtacgttc atatgaaaca atctgcagaa agtggggtaa gaaagggcac atggcacagt   3997

 taaagttgta gaaatcaaat tactatcatt ttttgttgcc aaaacaaagt cttacattta   4057

 accccccttt ctaccacccc cctccacact tcacgtcagc tacatagttt ccacagggta   4117

 attcactaag agcttgtgga gcttggtttt aaaatcctta gcctggtctg actttaggca   4177

 tagcttccag ttcttccttc cttgtcctgg tttcttgttc agcttttact tctaatccaa   4237

 caacaaaaga aatgtctggc tggtctcagc tagagtctga tgtgtcttag agcatgtgtg   4297

 cgtatctgaa ccatcatccc tgctctcatc tcagctccct ccaggcctga gcaccggttc   4357

 cttttgtccc atacgtcatg aagtcacact attgggaaac ctgtgcttcc ctctccatgg   4417

 cttaactccc tgtcagtgtc ggagtgtata agaatgcttg taaatactgt aatatattta   4477

 ttaatatttg aaaggcattc attcagtgga cagtgggaat taactctccc aaggcaagtg   4537

 aaaatgaatg attgacgtac gttgatttaa caatcttact agattttaat tcttaaggat   4597

 ttcaaatgaa accagaaggt ggttatgtaa gaggcttaaa atgatcttat gtttaaagag   4657

 attctgttat tagcaccatg aactcgtact atgaaatttt taagcctttt atttttctaa   4717

 ctatattact gtaggactgg atattaggtg tcatatagga aacacaaaag ttattgctgt   4777

 ttgctaaagc aaaatagcag aaaattttgt atatgaaaaa ctgttgaagg accatagaga   4837

 aatgtgtact actgacgggg cttttactag gcttcctgcg tgtgtaaaag tcgaggtatt   4897

 gctggcattc agggtgacat gatggtacta aatgttttcc attaaagtct tctattttaa   4957

 aatttagaga aaaataaaat ggctttccat cagaaaaaaa aaaaa                   5002




      <210> 110
      <211> 2936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (740)..(1318)

      <400> 110
 taagcttgcg gccgcccgga ggtagctacc acggcctgtg tcaacgacta aagctccagt     60

 acagcggcgc cctcagacag ctgggagggt ggctctggcc gggagcggcg gccggtgagc    120

 taccgcgagg aggagcggcg gaggcgacct cggcccggcc ctgcactggc cgcccggcag    180

 gcgcgacatg agcctggtct ggcatccgcg ggatgctcct taagcccctt ctccggctgt    240

 taacctccgg ggaacggttg tgaccacacc gacacgtatt ttacagataa atcattcttg    300

 cggcggcggg tcgaacacgt ttatttattt tttattttct caacaagctt ttacccagca    360

 cctgtccagt gaaacaactt gataatcgtt tcgaggggcg tccgccgggt taggaagcca    420

 ctgcctggca gcttgtggaa gcctcatttg caaagccacc cctcagatgt tttgaagatc    480

 gtgacgtctt gtaactagca gtgtgtgcac agaatcctac tcaaggaacg tcttggccca    540

 gcgatgcaaa gaactgaagt ttcaagctgg aagagcctgt attgtcctca caatagtata    600

 gaagaattca agagaggaga gagagacagc accgaatgaa gactgtaaaa gaaaagaagg    660

 aatgccagag attgagaaaa tctgccaaga ctaggagggt aacccagagg aaaccgtctt    720

 cagggcctgt ttgctggct atg ctt cga gaa cct ggg gat ccc gaa aaa tta     772
                      Met Leu Arg Glu Pro Gly Asp Pro Glu Lys Leu
                        1               5                  10

 ggg gaa ttt ctt cag aaa gac aat atc agc gtg cat tat ttc tgt ctt      820
 Gly Glu Phe Leu Gln Lys Asp Asn Ile Ser Val His Tyr Phe Cys Leu
              15                  20                  25

 atc tta tct agt aag ctg cct cag agg ggc cag tcc aac aga ggt ttc      868
 Ile Leu Ser Ser Lys Leu Pro Gln Arg Gly Gln Ser Asn Arg Gly Phe
          30                  35                  40

 cat gga ttt ctg cct gaa gac atc aaa aag gag gca gcc cgg gct tct      916
 His Gly Phe Leu Pro Glu Asp Ile Lys Lys Glu Ala Ala Arg Ala Ser
      45                  50                  55

 agg aag atc tgc ttt gtg tgc aag aaa aag gga gct gct atc aac tgc      964
 Arg Lys Ile Cys Phe Val Cys Lys Lys Lys Gly Ala Ala Ile Asn Cys
  60                  65                  70                  75

 cag aag gat cag tgc ctc aga aac ttc cat ctg cct tgt ggc caa gaa     1012
 Gln Lys Asp Gln Cys Leu Arg Asn Phe His Leu Pro Cys Gly Gln Glu
                  80                  85                  90

 agg ggt tgc ctt tca caa ttt ttt gga gag tac aaa tca ttt tgt gac     1060
 Arg Gly Cys Leu Ser Gln Phe Phe Gly Glu Tyr Lys Ser Phe Cys Asp
              95                 100                 105

 aaa cat cgc cca aca cag aac atc caa cat ggg cat gtg ggg gag gaa     1108
 Lys His Arg Pro Thr Gln Asn Ile Gln His Gly His Val Gly Glu Glu
         110                 115                 120

 agc tgc atc tta tgt tgt gaa gac tta tcc caa cag agt gtt gag aac     1156
 Ser Cys Ile Leu Cys Cys Glu Asp Leu Ser Gln Gln Ser Val Glu Asn
     125                 130                 135

 atc cag agc ccg tgt tgt agt caa gcc atc tac cac cgc aag tgc ata     1204
 Ile Gln Ser Pro Cys Cys Ser Gln Ala Ile Tyr His Arg Lys Cys Ile
 140                 145                 150                 155

 cag aaa tat gcc cac aca tca gca aag cat ttc ttc aaa tgt cca cag     1252
 Gln Lys Tyr Ala His Thr Ser Ala Lys His Phe Phe Lys Cys Pro Gln
                 160                 165                 170

 tgt aac aat cga aaa gag ttt cct caa gaa atg ctg aga atg gga att     1300
 Cys Asn Asn Arg Lys Glu Phe Pro Gln Glu Met Leu Arg Met Gly Ile
             175                 180                 185

 cat att cca gac agg tag tgggaa ccccaaagca ggaactgagc cagggagtgg     1354
 His Ile Pro Asp Arg 
         190

 gttgcctaga tttctagaga ggaggtgagt gagaggatag ttcagagaat gagagcagca   1414

 gaggcactga taagaaggaa ggggaggagg gagtgctttt caattatcaa aacagaaggg   1474

 agggggaaga agtttgcggg ggaatggggt gcttgttgct gaaaagggca tttggggaat   1534

 cagaattccc tggggggttg agttattgga ttccagagtg gaactaagga acctgcatgc   1594

 atgttccatt catcctgctt caaccctctc ccactgccag gccacttggc cagccttgtt   1654

 ggaagtgttc aggcagccta ctgaactctt gctgtgctta gcttgggctc ttcctaactc   1714

 ctccctgatg gacaaaagtt tcaccaaccc attatgttct tattcactgt ttcttctccc   1774

 actgcagaga tgctgcctgg gaactcgagc caggggcttt ctcagactta tatcagcgct   1834

 atcagcactg tgatgccccc atctgtctgt atgaacaagg cagagacagc tttgaggatg   1894

 aagggtaggg gaaggcttct ggctagaaag agctctcatc agtgctatct tagagttaga   1954

 ccttggcaca gttattagaa gtaagaaatt cactcttgta tgcagacctt aggataaaca   2014

 cgattgctaa gtctcattct tgaccagccc gactcacttg tgtgcacgtg aacacgtctc   2074

 ccctgcaagg tccgcttcac cttgtgccca gtggagagac attcagagcc aattcctttc   2134

 ctaatctacc tttcaagggg ttacgactga tggcaggctt ctgggatcag cactcatcct   2194

 ctctgagcca tacattcatc ttgggtaaaa tgtgctgtaa aaaatgcctg gcccatagca   2254

 aacatccaag catggcagtt ggtgttctgt atgtctccac aacccttcct gggctcttcc   2314

 tctaggaggt ggtgcctcat tctgtgtgct acatgcggat cccacggaac ccacagggac   2374

 tgctcctctc ttagatctaa cagtaagaaa tgggactgtg aggagtgttc acctgctgca   2434

 gccacagact acatacctga aaactcaggg gacatccctt gctgcagcag caccttccac   2494

 cctgaggaac atttctgcag agacaacacc ttggaagaga atccgggcct ttcttggact   2554

 gattggccag aaccttcctt attagaaaag ccagagtcct ctcgtggcag gaggagctac   2614

 tcctggaggt ccaagggtgt tctgtatgtc tccacaaccg ttcctgggct cttcctctag   2674

 gaggtggtgc ctcattctgt gtgctacatg cggatcccac ggaacccaca gggactgctc   2734

 ctctcttaga tctaacagta agaaatggga gaatcagcag aacctgtagg atcttatttg   2794

 gaattgacat tctctattgt aattttgttc ctgtttattt ttaaattttc tttttgtttc   2854

 actggacagg aaagatgatg ctcagtttta aacgttaaaa gtgtacaagt tgctttgtta   2914

 caataaaact aaatgtgtac ac                                            2936




      <210> 111
      <211> 1014
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (549)..(716)

      <400> 111
 ggggatgtag agggggttgg aggccgggag actattcgca ttctgtatca gaggaaaacg     60

 aaagaaaaag agaccaaagc tttgaagact tttaaatcca accctattgt gggcacattc    120

 cttgtatact gagggcaatg gagctacaga gcattaacaa atactcatct tcccagattt    180

 ttttccccat attttatgag ctatattttt cctgatatgt ttatctttga agactcttta    240

 aaattaggcc ctattccata atttctatac aacaaaatta tgtcctcctg cctactttta    300

 attgaattta agtctgcgcc tgttgtgatg cttctgtgat aatccttttg ctgaatggcg    360

 taagatctct actaagatcc atttggctta aacctaataa acactagtga acacatcctt    420

 aaatgacttt tgtttatttc ctttaagtaa cacttccaaa aaaacaaatt caaggcaatt    480

 caatattcag cattagctag acttatgagc cattactgaa atttctactg actttatcaa    540

 attttttc atg gaa tct ccc aaa tgc cta tac tca cgc ata act gtt aac     590
          Met Glu Ser Pro Lys Cys Leu Tyr Ser Arg Ile Thr Val Asn
            1               5                  10

 acg gca ttt ggt act aaa ttc tca cac ata agc ttt att ata tta ttt      638
 Thr Ala Phe Gly Thr Lys Phe Ser His Ile Ser Phe Ile Ile Leu Phe
  15                  20                  25                  30

 aag gta ttc tta ttc cca aga att act att tca aag aaa acc aag ttg      686
 Lys Val Phe Leu Phe Pro Arg Ile Thr Ile Ser Lys Lys Thr Lys Leu
                  35                  40                  45

 gtc act tta agc aac tat ttg aat aaa tga a aaactgaagt aattctcagg      737
 Val Thr Leu Ser Asn Tyr Leu Asn Lys 
              50                  55

 tgctttgaga gttctctgtt taatttaaaa acgttttggg ggagaagtaa aatagtggcc    797

 tttgaaaaaa tatgctgaca caagacatat tgaattttgt ggttttaaaa aattaacaaa    857

 taatgaactt ggcattttat taaatgcatc gaaaagggtc aagttatttt taatagaaaa    917

 tccataattc tattaaatgg ttgagaaatt agtcacatca atagacttct ttcatttctg    977

 agcccatctt ctgtactgct acaagttcct ttggcaa                            1014




      <210> 112
      <211> 682
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(338)

      <400> 112
 atttggccct cgagcagtaa attcggcacg aggcggatcg gtcggaa  atg gca gag      56
                                                      Met Ala Glu
                                                        1

 gtg gag gag aca ctg aag cga ctg cag agc cag aag gga gtg cag gga      104
 Val Glu Glu Thr Leu Lys Arg Leu Gln Ser Gln Lys Gly Val Gln Gly
       5                  10                  15

 atc atc gtc gtg aac aca gaa ggc att ccc atc aag agc acc atg gac      152
 Ile Ile Val Val Asn Thr Glu Gly Ile Pro Ile Lys Ser Thr Met Asp
  20                  25                  30                  35

 aac ccc acc acc acc cag tat gcc agc ctc atg cac agc ttc atc ctg      200
 Asn Pro Thr Thr Thr Gln Tyr Ala Ser Leu Met His Ser Phe Ile Leu
                  40                  45                  50

 aag gca cgg agc acc gtg cgt gac atc gac ccc cag aac gat ctc acc      248
 Lys Ala Arg Ser Thr Val Arg Asp Ile Asp Pro Gln Asn Asp Leu Thr
              55                  60                  65

 ttc ctt cga att cgc tcc aag aaa aat gaa att atg gtt gca cca gat      296
 Phe Leu Arg Ile Arg Ser Lys Lys Asn Glu Ile Met Val Ala Pro Asp
          70                  75                  80

 aaa gac tat ttc ctg att gtg att cag aat cca acc gaa taa gccactc      345
 Lys Asp Tyr Phe Leu Ile Val Ile Gln Asn Pro Thr Glu 
      85                  90                  95

 tcttggctcc ctgtgtcatt ccttaattta atgcccccca agaatgttaa tgtcaatcat    405

 gtcagtggac tagcacatgg cagtcgcttg gaacccactc acaccaatcc agtgaccgtg    465

 tgtgggctgg cggctcttct cccccaccaa cggaacccct gtgtgcacca accttcccca    525

 gagctccgga gcgccctctc ctcacttcca ggttttggag caagagcttg caggaagccc    585

 gcacccagct tccttctgac cttcagttca ctttgtcgcc cttggagaaa gctgtttttc    645

 tttaactaaa aataaccaaa atgctaaaaa aaaaaaa                             682




      <210> 113
      <211> 1887
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(1325)

      <400> 113
 atttggccct cgaggcaaga attcggcacg aggggcgcgg tcgagtcatc gcagggcctc     60

 accgcttcgt tctcccgtcc ctccccgcgc cttggcgcgg ggggtcgact agccaagtga    120

 ggcgggaggc gactcggacc tttccctgca tttcgtttcg gccagtgccg ggggctaccc    180

 gccctggggc ctgggatcct tggggcccgt gaggcccact cttagcggcc ggggcctacc    240

 gcggcccgcc gctggccctc    atg agg cat agc ctg acc aag ctg ctg gca     290
                          Met Arg His Ser Leu Thr Lys Leu Leu Ala
                            1               5                  10

 gcc tcg ggc agc aac tcc cca acc cgc agt gag agc ccg gag ccg gct      338
 Ala Ser Gly Ser Asn Ser Pro Thr Arg Ser Glu Ser Pro Glu Pro Ala
                  15                  20                  25

 gca act tgt tcg ctg ccc tct gac ctg acc cgg gct gca gcg ggg gag      386
 Ala Thr Cys Ser Leu Pro Ser Asp Leu Thr Arg Ala Ala Ala Gly Glu
              30                  35                  40

 gag gag acg gcg gcg gcc gga tct ccc ggc cgc aag cag cag ttt ggc      434
 Glu Glu Thr Ala Ala Ala Gly Ser Pro Gly Arg Lys Gln Gln Phe Gly
          45                  50                  55

 gac gaa gga gag ttg gaa gcc ggg agg ggg agc cgc ggc ggc gtg gcc      482
 Asp Glu Gly Glu Leu Glu Ala Gly Arg Gly Ser Arg Gly Gly Val Ala
      60                  65                  70

 gtg cgc gcg ccc tcc ccc gag gag atg gag gag gag gcg atc gcc agc      530
 Val Arg Ala Pro Ser Pro Glu Glu Met Glu Glu Glu Ala Ile Ala Ser
  75                  80                  85                  90

 ctc ccg ggg gaa gag acg gag gat atg gac ttt ctg tct ggg ctg gaa      578
 Leu Pro Gly Glu Glu Thr Glu Asp Met Asp Phe Leu Ser Gly Leu Glu
                  95                 100                 105

 ctg gcg gat ctc ctg gac ccc agg caa ccg gac tgg cac ctg gac ccc      626
 Leu Ala Asp Leu Leu Asp Pro Arg Gln Pro Asp Trp His Leu Asp Pro
             110                 115                 120

 ggg ctt agc tcg ccg ggg cct ctc tcc tcg tct ggc gga ggc tcg gat      674
 Gly Leu Ser Ser Pro Gly Pro Leu Ser Ser Ser Gly Gly Gly Ser Asp
         125                 130                 135

 agc ggc ggc ctg tgg aga ggg gac gat gac gat gag gcc gcg gct gct      722
 Ser Gly Gly Leu Trp Arg Gly Asp Asp Asp Asp Glu Ala Ala Ala Ala
     140                 145                 150

 gaa atg cag cgc ttc tct gac ctg ctg caa agg ctg tta aac ggt atc      770
 Glu Met Gln Arg Phe Ser Asp Leu Leu Gln Arg Leu Leu Asn Gly Ile
 155                 160                 165                 170

 gga ggc tgc agc agc agc agt gac agt ggc agc gcc gaa aag agg cgg      818
 Gly Gly Cys Ser Ser Ser Ser Asp Ser Gly Ser Ala Glu Lys Arg Arg
                 175                 180                 185

 aga aag tcc cca gga gga ggc ggc ggt ggc ggc agc ggt aac gac aac      866
 Arg Lys Ser Pro Gly Gly Gly Gly Gly Gly Gly Ser Gly Asn Asp Asn
             190                 195                 200

 aac cag gcg gcg aca aag agt ccc cgg aag gcg gcg gcg gcc gct gcc      914
 Asn Gln Ala Ala Thr Lys Ser Pro Arg Lys Ala Ala Ala Ala Ala Ala
         205                 210                 215

 cgc ctt aat cga ctg aag aag aag gag tac gtg atg ggg ctg gag agt      962
 Arg Leu Asn Arg Leu Lys Lys Lys Glu Tyr Val Met Gly Leu Glu Ser
     220                 225                 230

 cga gtc cgg ggt ctg gca gcc gag aac cag gag ctg cgg gcc gag aat     1010
 Arg Val Arg Gly Leu Ala Ala Glu Asn Gln Glu Leu Arg Ala Glu Asn
 235                 240                 245                 250

 cgg gag ctg ggc aaa cgc gta cag gca ctg cag gag gag agt cgc tac     1058
 Arg Glu Leu Gly Lys Arg Val Gln Ala Leu Gln Glu Glu Ser Arg Tyr
                 255                 260                 265

 cta cgg gca gtc tta gcc aac gag act gga ctg gct cgc ttg ctg agc     1106
 Leu Arg Ala Val Leu Ala Asn Glu Thr Gly Leu Ala Arg Leu Leu Ser
             270                 275                 280

 cgg ctg agc ggc gtg gga ctg cgg ctg acc acc tcg ctc ttc aga gac     1154
 Arg Leu Ser Gly Val Gly Leu Arg Leu Thr Thr Ser Leu Phe Arg Asp
         285                 290                 295

 tcg ccc gcc ggt gac cac gac tac gct ctg cca gtg gga aag cag aag     1202
 Ser Pro Ala Gly Asp His Asp Tyr Ala Leu Pro Val Gly Lys Gln Lys
     300                 305                 310

 cag gac ctg ctg gaa gag gac gac tcg gcg gga gga gtc tgt ctc cat     1250
 Gln Asp Leu Leu Glu Glu Asp Asp Ser Ala Gly Gly Val Cys Leu His
 315                 320                 325                 330

 gtg gac aag gat aag gtg tcg gtg gag ttc tgc tcg gcg tgc gcc cgg     1298
 Val Asp Lys Asp Lys Val Ser Val Glu Phe Cys Ser Ala Cys Ala Arg
                 335                 340                 345

 aag gcg tcg tct tct ctt aaa atg tag ggtca agtaatctgc tctttatccg     1350
 Lys Ala Ser Ser Ser Leu Lys Met 
             350

 cgtttacccc tttcaactcc cttacaccat gtcaaactta ccttagtggg acatcttcac   1410

 cggacacatt tcagaggaga gaaaaaaagt aatattgaat cttaaagtgt ttagctaaaa   1470

 gcatgaatgt gacacagtaa ccaactccta atgataacat gtgactatta aatctctctg   1530

 acagtttctt ttttaggtga tttccttcct gccaggctcc gttgtagggg ttacagaaca   1590

 gtcgttcccg cctcacaacc tgtggataca gctgttgggg cagaagagac gggaccagct   1650

 gctggccaca tttcctgctt tattttaaaa ggtagtataa aaaatgagga aaaagaggta   1710

 atatcagggc ttctgctgtt ttttattttt aacatgttca taattaaaaa gtattttcca   1770

 gcagtccaaa gatgtaagtt atcttacaca taaaatgttt tattttgtta tttggttatg   1830

 aaaatggaat ccttgttcgc acgcgtgggc ggacgcgtgg gtcgacccgg gaagtcc      1887




      <210> 114
      <211> 1242
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(780)

      <400> 114
 gaaaactctg aggac atg aat agt cgc cag gct tgg cgg ctc ttt ctc tcc      51
                  Met Asn Ser Arg Gln Ala Trp Arg Leu Phe Leu Ser
                    1               5                  10

 caa ggc aga gga gat cgt tgg gtt tca agg ccc cgc ggg cat ttc tcg       99
 Gln Gly Arg Gly Asp Arg Trp Val Ser Arg Pro Arg Gly His Phe Ser
          15                  20                  25

 ccg gcc ctg cgg aga gag ttc ttc act acc aca acc aag gag gga tat      147
 Pro Ala Leu Arg Arg Glu Phe Phe Thr Thr Thr Thr Lys Glu Gly Tyr
      30                  35                  40

 gat agg cgg cca gtg gat ata act cct tta gaa caa agg aaa tta act      195
 Asp Arg Arg Pro Val Asp Ile Thr Pro Leu Glu Gln Arg Lys Leu Thr
  45                  50                  55                  60

 ttt gat acc cat gca ttg gtt cag gac ttg gaa act cat gga ttt gac      243
 Phe Asp Thr His Ala Leu Val Gln Asp Leu Glu Thr His Gly Phe Asp
                  65                  70                  75

 aaa aca caa gca gaa aca att gta tca gcg tta act gct tta tca aat      291
 Lys Thr Gln Ala Glu Thr Ile Val Ser Ala Leu Thr Ala Leu Ser Asn
              80                  85                  90

 gtc agc ctg gat act atc tat aaa gag atg gtc act caa gct caa cag      339
 Val Ser Leu Asp Thr Ile Tyr Lys Glu Met Val Thr Gln Ala Gln Gln
          95                 100                 105

 gaa ata aca gta caa cag cta atg gct cat ttg gat gct atc agg aaa      387
 Glu Ile Thr Val Gln Gln Leu Met Ala His Leu Asp Ala Ile Arg Lys
     110                 115                 120

 gac atg gtc atc cta gag aaa agt gaa ttt gca aat ctg aga gca gag      435
 Asp Met Val Ile Leu Glu Lys Ser Glu Phe Ala Asn Leu Arg Ala Glu
 125                 130                 135                 140

 aat gag aaa atg aaa att gaa tta gac caa gtt aag caa caa cta atg      483
 Asn Glu Lys Met Lys Ile Glu Leu Asp Gln Val Lys Gln Gln Leu Met
                 145                 150                 155

 cat gaa acc agt cga atc aga gca gat aat aaa ctg gat atc aac tta      531
 His Glu Thr Ser Arg Ile Arg Ala Asp Asn Lys Leu Asp Ile Asn Leu
             160                 165                 170

 gaa agg agc aga gta aca gat atg ttt aca gat caa gaa aag caa ctt      579
 Glu Arg Ser Arg Val Thr Asp Met Phe Thr Asp Gln Glu Lys Gln Leu
         175                 180                 185

 atg gaa aca act aca gaa ttt aca aaa aag gat act caa acc aaa agt      627
 Met Glu Thr Thr Thr Glu Phe Thr Lys Lys Asp Thr Gln Thr Lys Ser
     190                 195                 200

 att att tca gag acc agt aat aaa att gac gct gaa att gct tcc tta      675
 Ile Ile Ser Glu Thr Ser Asn Lys Ile Asp Ala Glu Ile Ala Ser Leu
 205                 210                 215                 220

 aaa aca ctg atg gaa tct aac aaa ctt gag aca att cgt tat ctt gca      723
 Lys Thr Leu Met Glu Ser Asn Lys Leu Glu Thr Ile Arg Tyr Leu Ala
                 225                 230                 235

 gct tcg gtg ttt act tgc ctg gca ata gca ttg gga ttt tat aga ttc      771
 Ala Ser Val Phe Thr Cys Leu Ala Ile Ala Leu Gly Phe Tyr Arg Phe
             240                 245                 250

 tgg aag tag tattaat gctcatcctg ctgtggctgt tggcttctta gaacaccaaa      827
 Trp Lys 


 ccgggagaga tttactttga acattgtcag ttgcagcaaa aatttactac acaagattat    887

 tcgaagtgta tacggactaa aagaggaagt gttttagaat gagaagagat actgtgtctt    947

 tattgtgtgt gtgtgagtgc aggtgtgtgt ctttattata ttgaaaagct gtcactcaga   1007

 cctggtttga gatagaagag cattttgtcc ttttgatagt taatagaaat tgaaccagag   1067

 ttttcttatg tttgcttgaa cagttgtgta aatcatacag gattttgtgg gtattggttg   1127

 aatatttgta aaccattccc tagcctacat atttattact gaattaactt tcctgataac   1187

 cattgcataa ttacattttt ctataaaatg aaagattatt acaaaaaaaa aaaaa        1242




      <210> 115
      <211> 1441
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (799)..(1263)

      <400> 115
 agaaaattta tttctacttc tacagcagaa atacggaaat ggtacaggtt tgggcaaatc     60

 atactttatg aaatggatcc tcataccaca tcctttttaa tacaggcacg ttataacata    120

 attcctggat tttcaaaatc cagccaacac ggatacctct gctactctgt tttggccttc    180

 atagctgctt cctctttcag acgagctttc ttttctaagt tcaagcttgt taaagtctcg    240

 tgtctttggg cagccttctt gccctcaata accatgaaga tgcatcctac caccgtcagg    300

 gcaatcatta gatagctgat cttcactcgc atcttgttct ttgcagcatc aagcatctcc    360

 aacgagacag tctctgggat ttcatcttcc tttttgaagc gacctgacca tatgaggatc    420

 tttttctgcc aatccgtagg tttgtgtaaa ggcactctgt tgtaagtgcg ggatggagct    480

 ccgggacttt cctgtggttt tgtgcaaaat ccatttattc tcttcaaatc agagcttctg    540

 gtaagcctta gagatgagga aacatctctt tcacataacc taaaacagct tcctgctgcc    600

 aggcgcagac cgctgaggct ccccagcgcc acttgttact ccgccgacca gcgcagaact    660

 tcgccgggga cggtggcgct ggtgagctca acccacgcgt ccgcggacgc gtgggtgcgg    720

 acgcgtgggc ggacgcgtgg gaccagcgcc accgtccccg gcgaagttct gcgctggtcg    780

 gcggagtagc aagtggcc  atg ggg agc ctc agc ggt ctg cgc ctg gca gca     831
                      Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala
                        1               5                  10

 gga agc tgt ttt agg tta tgt gaa aga gat gtt tcc tca tct cta agg      879
 Gly Ser Cys Phe Arg Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg
              15                  20                  25

 ctt acc aga agc tct gat ttg aag aga ata aat gga ttt tgc aca aaa      927
 Leu Thr Arg Ser Ser Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys
          30                  35                  40

 cca cag gaa agt ccc gga gct cca tcc cgc act tac aac aga gtg cct      975
 Pro Gln Glu Ser Pro Gly Ala Pro Ser Arg Thr Tyr Asn Arg Val Pro
      45                  50                  55

 tta cac aaa cct acg gat tgg cag aaa aag atc ctc ata tgg tca ggt     1023
 Leu His Lys Pro Thr Asp Trp Gln Lys Lys Ile Leu Ile Trp Ser Gly
  60                  65                  70                  75

 cgc ttc aaa aag gaa gat gaa atc cca gag act gtc tcg ttg gag atg     1071
 Arg Phe Lys Lys Glu Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met
                  80                  85                  90

 ctt gat gct gca aag aac aag atg cga gtg aag atc agc tat cta atg     1119
 Leu Asp Ala Ala Lys Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met
              95                 100                 105

 att gcc ctg acg gtg gta gga tgc atc ttc atg gtt att gag ggc aag     1167
 Ile Ala Leu Thr Val Val Gly Cys Ile Phe Met Val Ile Glu Gly Lys
         110                 115                 120

 aag gct gcc caa aga cac gag act tta aca agc ttg aac tta gaa aag     1215
 Lys Ala Ala Gln Arg His Glu Thr Leu Thr Ser Leu Asn Leu Glu Lys
     125                 130                 135

 aaa gct cgt ctg aaa gag gaa gca gct atg aag gcc aaa aca gag tag     1263
 Lys Ala Arg Leu Lys Glu Glu Ala Ala Met Lys Ala Lys Thr Glu 
 140                 145                 150

 cagaggtatc cgtgttggct ggattttgaa aatccaggaa ttatgttata acgtgcctgt   1323

 attaaaaagg atgtggtatg aggatccatt tcataaagta tgatttgccc aaacctgtac   1383

 catttccgta tttctgctgt agaagtagaa ataaattttc ttaaataaaa aaaaaaaa     1441




      <210> 116
      <211> 978
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(312)

      <400> 116
 agttcaaaag gtaactacta tatttggaag tattattcac acatagtgtc ttgcatagag     60

 tagaccttca ataaaatata tgtgttaacg aagattatac tttcaaatga aagtaatatt    120

 tgcttgtttg tttttaaaca gatagccatc acaactcaat gtaactgc atg cac ttt     177
                                                      Met His Phe
                                                        1

 ctt gtc gtc att tgg aac cag gct tct atc aac tac tat act agt cga      225
 Leu Val Val Ile Trp Asn Gln Ala Ser Ile Asn Tyr Tyr Thr Ser Arg
       5                  10                  15

 ggg gct tta gac ctt tcc tct gag gag ggc tgg cat ctc ttc agg ttt      273
 Gly Ala Leu Asp Leu Ser Ser Glu Glu Gly Trp His Leu Phe Arg Phe
  20                  25                  30                  35

 aac aga gaa gaa ctc ctg gac atg gca tgg gaa gaa tga aagaggcttt       322
 Asn Arg Glu Glu Leu Leu Asp Met Ala Trp Glu Glu 
                  40                  45

 gtaacaactc atcccaacac agcctccaac atttgactgt cacctgagtc taacagcagt    382

 ttgactttgt tgtacaatac agcaagtgat catcacattc ttgtttgagc agatctttta    442

 ttttgaaaca gattttgtag ctctagtcaa ctttccatta tccaaaccaa tattctaacg    502

 gctagtagca gtagtgataa tccaaaagag cagataattt aaaagtcact tatacttagc    562

 tttgcgctat tttttaccta tcatatttca tcaaaattaa ggtgcttttc acaatttgac    622

 atatctgatg tcgggataaa tgtaatgatc aactggcagc attttttgtt tgtttgtttt    682

 tagaggcagg atcttgctat gttgctcagg ctggtctcaa acttttggcc tcaagcaatc    742

 ctcccacttc agcctcccag acacaagcaa ctctgctcag cctttttttt taaattaaag    802

 gtatatgata tgccctagac ttgatgaaat atgggtgttt gaatatattc agatctgagg    862

 tttaaaaaaa ttcatttcaa atactggaga taaactctga agagcctacc catgaaaaac    922

 tagcaagtaa actgcttccc taccctcgtg ccgaattctg ctctcgaggg tcaaat        978




      <210> 117
      <211> 2244
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (739)..(1053)

      <400> 117
 tgcatgtggt tagtcctctc ctcctgagat tcagaaccag ttgactgtcc ccttaggtgt     60

 ataaggagaa aagttgacat gtctgggacc tctgacatgt gtacacatgc ttgcacacat    120

 gcacacacag tgaatgtttt aagttataca aacataagac cttaagatgc aaagagccag    180

 aatattctaa agaggtgatg aacagagggg gtggaaactg catcacagat gttttccaag    240

 ggccagggtg gaatctgagc tctagtgtct gactttgaga tgcattatat ttttaacaca    300

 taaatgaggg gatccatatc acattctttc ttgtggacca ccaaattgaa ggctttcttg    360

 taattcacaa gcagcagctc tccagcatct ctccgtagcc tgggtgaagt cccagaagct    420

 ggtgtgcatc attttccaag gtggcagagc tgcttgctct gcagatcatt cctttgagag    480

 aggagtacaa gtgaagaaac aaggaggcac ttcctgtagg agcactgatg tgccttgtcc    540

 acactcccct ctgagcttta ctggtaagag agctccgact gaacatgctg agcagttgag    600

 cacttttcca tcagcaacaa cagcgaggat ggaaatggaa aggaaccgaa ctaaaatgca    660

 tttccctttg cagggcagag agctaagctc ttaggaatag tgttatagaa ataagcaccc    720

 taacttcaat tcctgaaa  atg ttg gtt aat gga gag aat ttt gga gtt tca     771
                      Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser
                        1               5                  10

 ctt aat att ttc cca tcg gtc gcc ata aat aag tct tca ggc gct cct      819
 Leu Asn Ile Phe Pro Ser Val Ala Ile Asn Lys Ser Ser Gly Ala Pro
              15                  20                  25

 aga aga gtc cca gcc caa ggc tcg att aag gac cac act gca ggt ctg      867
 Arg Arg Val Pro Ala Gln Gly Ser Ile Lys Asp His Thr Ala Gly Leu
          30                  35                  40

 agg ctc act gct ctg agt cct gaa cac cag agc cct gca gag agt ggt      915
 Arg Leu Thr Ala Leu Ser Pro Glu His Gln Ser Pro Ala Glu Ser Gly
      45                  50                  55

 gat aac aca tca tct ctg caa aga gga acc tct ccc ccg gcc gcc act      963
 Asp Asn Thr Ser Ser Leu Gln Arg Gly Thr Ser Pro Pro Ala Ala Thr
  60                  65                  70                  75

 tca ctc agg ctt cta ctg agc agc aag gac agc ctg ggt ttc aaa tgc     1011
 Ser Leu Arg Leu Leu Leu Ser Ser Lys Asp Ser Leu Gly Phe Lys Cys
                  80                  85                  90

 cac ttc ccc tgc ttt agg gat cca ggt gtc ctg ata gcg tga ccctgct     1060
 His Phe Pro Cys Phe Arg Asp Pro Gly Val Leu Ile Ala 
              95                 100

 gaggcaaggt atcaactccg agagtgactg agtcactgag cgtggcacat gaacaaacgt   1120

 catgacaaag attctctgag tgaagttaac accacgtatt ttacctttgc aaaaaacaaa   1180

 ctggcaccct gagttctaac tacggacgga cgatatcttt gcctccacac ccagattcct   1240

 ggaaatggct aacgtttcct ttctagggga agggtcgagg aatactcaag tgctagctta   1300

 gcagctttgt tcagtccaga tcagagctgt taggtaaagg cctaaccacc tccctgcagt   1360

 ctcttatatc tcaagcttta ggaacccatt tctaaatgta cactagcgga gaatttatat   1420

 tgtcagcctt gattaccata ggacaggcag aaaggcgata atttgtatct tttaatataa   1480

 aagaagcttt taacttttcc agcctattat aataactgag ttatattcac tgtggctcaa   1540

 actaattggc attgtggaac atttctttac cttcaaagtt ttctccacca atcatttcag   1600

 ttctattgca gtcctggtgc catatgtccc ctgcaaattg tgaaagtaat tagtgacaaa   1660

 atagcagcct gctccttttc aatggcgaaa ctgtcggcat tagcagtttt gggtaagctg   1720

 gcggtactat aacacgtact ggaaacctgt tcctcatcac cacctaccag attctggaaa   1780

 tgccgtcttc tagaaaacga tggcgtttgt ggtggtcttc ttttgaaagg aacagtaatt   1840

 tgtgtggata ttgttaaagt gtttaaagaa tattttgaca attaagttta cattttacaa   1900

 ttgctttatt ttttattaaa atagttgtat ataaatatta ccctatttca ctgttgttca   1960

 agtaaatcta aaccttgtag acaagtgagt catctgatat gtatagaagc tgtgatatat   2020

 agagtacatt tattgtgtaa atgtttatga atataattgt tcctgtgttt ttataagttg   2080

 gggatatttt gttgttttac ggcaacaaaa tttattgcat ttaaatggtt tttatgtaat   2140

 agaaatcacg caaaatagtg aaggatttaa aatatgtata tgatacatgt aaatgtacaa   2200

 actttagaaa gaaataaatc caacaaattt caaaaaaaaa aaaa                    2244




      <210> 118
      <211> 14785
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(11932)

      <400> 118
 taagcttgcg gccgcctggg tcccggcggc acggacgttg gcactctggt tagggacatg     60

 ctgaagatcc cggggaggca aagttggtac ttcaaacccg gctcttaaca catatctaca    120

 ccgcgagggg atcacggagc tgccgaggac tttagagccc agggccgagg actcggctag    180

 actgattccc gacagttaag ca atg ggg aga cat ttg gct ttg ctc ctg ctt     232
                          Met Gly Arg His Leu Ala Leu Leu Leu Leu
                            1               5                  10

 ctg ctc ctt ctc ttc caa cat ttt gga gac agt gat ggc agc caa cga      280
 Leu Leu Leu Leu Phe Gln His Phe Gly Asp Ser Asp Gly Ser Gln Arg
                  15                  20                  25

 ctt gaa cag act cct ctg cag ttt aca cac ctc gag tac aac gtc acc      328
 Leu Glu Gln Thr Pro Leu Gln Phe Thr His Leu Glu Tyr Asn Val Thr
              30                  35                  40

 gtg cag gag aac tct gca gct aag act tat gtg ggg cat cct gtc aag      376
 Val Gln Glu Asn Ser Ala Ala Lys Thr Tyr Val Gly His Pro Val Lys
          45                  50                  55

 atg ggt gtt tac att aca cat cca gcg tgg gaa gta agg tac aaa att      424
 Met Gly Val Tyr Ile Thr His Pro Ala Trp Glu Val Arg Tyr Lys Ile
      60                  65                  70

 gtt tcc gga gac agt gaa aac ctg ttc aaa gct gaa gag tac att ctc      472
 Val Ser Gly Asp Ser Glu Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu
  75                  80                  85                  90

 gga gac ttt tgc ttt cta aga ata agg acc aaa gga gga aat aca gct      520
 Gly Asp Phe Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala
                  95                 100                 105

 att ctt aat aga gaa gtg aag gat cac tac aca ttg ata gtg aaa gca      568
 Ile Leu Asn Arg Glu Val Lys Asp His Tyr Thr Leu Ile Val Lys Ala
             110                 115                 120

 ctt gaa aaa aat act aat gtg gag gcg cga aca aag gtc agg gtg cag      616
 Leu Glu Lys Asn Thr Asn Val Glu Ala Arg Thr Lys Val Arg Val Gln
         125                 130                 135

 gtg ctg gat aca aat gac ttg aga ccg tta ttc tca ccc acc tca tac      664
 Val Leu Asp Thr Asn Asp Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr
     140                 145                 150

 agc gtt tct tta cct gaa aac aca gct ata agg acc agt atc gca aga      712
 Ser Val Ser Leu Pro Glu Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg
 155                 160                 165                 170

 gtc agc gcc acg gat gca gac ata gga acc aac ggg gaa ttt tac tac      760
 Val Ser Ala Thr Asp Ala Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr
                 175                 180                 185

 agt ttt aaa gat cga aca gat atg ttt gct att cac cca acc agt ggt      808
 Ser Phe Lys Asp Arg Thr Asp Met Phe Ala Ile His Pro Thr Ser Gly
             190                 195                 200

 gtg ata gtg tta act ggt aga ctt gat tac cta gag acc aag ctc tat      856
 Val Ile Val Leu Thr Gly Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr
         205                 210                 215

 gag atg gaa atc ctc gct gcg gac cgt ggc atg aag ttg tat ggg agc      904
 Glu Met Glu Ile Leu Ala Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser
     220                 225                 230

 agt ggc atc agc agc atg gcc aag cta acg gtg cac atc gaa cag gcc      952
 Ser Gly Ile Ser Ser Met Ala Lys Leu Thr Val His Ile Glu Gln Ala
 235                 240                 245                 250

 aat gaa tgt gct ccg gtg ata aca gca gtg aca ttg tca cca tca gaa     1000
 Asn Glu Cys Ala Pro Val Ile Thr Ala Val Thr Leu Ser Pro Ser Glu
                 255                 260                 265

 ctg gac agg gac cca gca tat gca att gtg aca gtg gat gac tgc gat     1048
 Leu Asp Arg Asp Pro Ala Tyr Ala Ile Val Thr Val Asp Asp Cys Asp
             270                 275                 280

 cag ggt gcc aat ggt gac ata gca tct tta agc atc gtg gca ggt gac     1096
 Gln Gly Ala Asn Gly Asp Ile Ala Ser Leu Ser Ile Val Ala Gly Asp
         285                 290                 295

 ctt ctc cag cag ttt aga aca gtg agg tcc ttt cca ggg agt aag gag     1144
 Leu Leu Gln Gln Phe Arg Thr Val Arg Ser Phe Pro Gly Ser Lys Glu
     300                 305                 310

 tat aaa gtc aaa gcc atc ggt ggc att gat tgg gac agt cat cct ttc     1192
 Tyr Lys Val Lys Ala Ile Gly Gly Ile Asp Trp Asp Ser His Pro Phe
 315                 320                 325                 330

 ggc tac aat ctc aca cta cag gct aaa gat aaa gga act ccg ccc cag     1240
 Gly Tyr Asn Leu Thr Leu Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln
                 335                 340                 345

 ttc tct tct gtt aaa gtc att cac gtg act tct cca cag ttc aaa gcc     1288
 Phe Ser Ser Val Lys Val Ile His Val Thr Ser Pro Gln Phe Lys Ala
             350                 355                 360

 ggg cca gtc aag ttt gaa aag gat gtt tac aga gca gaa ata agt gaa     1336
 Gly Pro Val Lys Phe Glu Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu
         365                 370                 375

 ttt gct cct ccc aac aca cct gtg gtc atg gta aag gcc att cct gct     1384
 Phe Ala Pro Pro Asn Thr Pro Val Val Met Val Lys Ala Ile Pro Ala
     380                 385                 390

 tat tcc cat ttg agg tat gtt ttt aaa agg aca cct gga aaa gct aaa     1432
 Tyr Ser His Leu Arg Tyr Val Phe Lys Arg Thr Pro Gly Lys Ala Lys
 395                 400                 405                 410

 ttc agt tta aat tac aac act ggt ctc att tct att tta gaa cca gtt     1480
 Phe Ser Leu Asn Tyr Asn Thr Gly Leu Ile Ser Ile Leu Glu Pro Val
                 415                 420                 425

 aaa aga cag cag gca gcc cat ttt gaa ctt gaa gta aca aca agt gac     1528
 Lys Arg Gln Gln Ala Ala His Phe Glu Leu Glu Val Thr Thr Ser Asp
             430                 435                 440

 aga aaa gcg tcc acc aag gtc ttg gtg aaa gtc tta ggt gca aat agc     1576
 Arg Lys Ala Ser Thr Lys Val Leu Val Lys Val Leu Gly Ala Asn Ser
         445                 450                 455

 aat ccc cct gaa ttt acc cag aca gcg tac aaa gct gct ttt gat gag     1624
 Asn Pro Pro Glu Phe Thr Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu
     460                 465                 470

 aac gtg ccc att ggt act act atc atg agc ctg agt gcc gta gac cct     1672
 Asn Val Pro Ile Gly Thr Thr Ile Met Ser Leu Ser Ala Val Asp Pro
 475                 480                 485                 490

 gat gag ggt gag aat ggg tac gtg aca tac agt atc gca aat tta aat     1720
 Asp Glu Gly Glu Asn Gly Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn
                 495                 500                 505

 cat gtg ccg ttt gcg att gac cat ttc act ggt gcc gtg agt acg tca     1768
 His Val Pro Phe Ala Ile Asp His Phe Thr Gly Ala Val Ser Thr Ser
             510                 515                 520

 gaa aac ctg gac tac gaa ctg atg cct cgg gtt tat act ctg agg att     1816
 Glu Asn Leu Asp Tyr Glu Leu Met Pro Arg Val Tyr Thr Leu Arg Ile
         525                 530                 535

 cgt gca tca gac tgg ggc ttg ccg tac cgc cgg gaa gtc gaa gtc ctt     1864
 Arg Ala Ser Asp Trp Gly Leu Pro Tyr Arg Arg Glu Val Glu Val Leu
     540                 545                 550

 gct aca att act ctc aat aac ttg aat gac aac aca cct ttg ttt gag     1912
 Ala Thr Ile Thr Leu Asn Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu
 555                 560                 565                 570

 aaa ata aat tgt gaa ggg aca att ccc aga gat cta ggc gtg gga gag     1960
 Lys Ile Asn Cys Glu Gly Thr Ile Pro Arg Asp Leu Gly Val Gly Glu
                 575                 580                 585

 caa ata acc act gtt tct gct att gat gca gat gaa ctt cag ttg gta     2008
 Gln Ile Thr Thr Val Ser Ala Ile Asp Ala Asp Glu Leu Gln Leu Val
             590                 595                 600

 cag tat cag att gaa gct gga aat gaa ctg gat ttg ttt agt tta aac     2056
 Gln Tyr Gln Ile Glu Ala Gly Asn Glu Leu Asp Leu Phe Ser Leu Asn
         605                 610                 615

 ccc aac tcg ggg gta ttg tca tta aag cga tcg cta atg gat ggc tta     2104
 Pro Asn Ser Gly Val Leu Ser Leu Lys Arg Ser Leu Met Asp Gly Leu
     620                 625                 630

 ggt gca aag gtg tct ttc cac agt ctg aga atc aca gct aca gat gga     2152
 Gly Ala Lys Val Ser Phe His Ser Leu Arg Ile Thr Ala Thr Asp Gly
 635                 640                 645                 650

 gaa aat ttt gcc aca cca tta tat atc aac ata aca gtg gct gcc agt     2200
 Glu Asn Phe Ala Thr Pro Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser
                 655                 660                 665

 cac aag ctg gta aac ttg cag tgt gaa gag act ggt gtt gcc aaa atg     2248
 His Lys Leu Val Asn Leu Gln Cys Glu Glu Thr Gly Val Ala Lys Met
             670                 675                 680

 ctg gca gag aag ctc ctg cag gca aat aaa tta cac aac cag gga gag     2296
 Leu Ala Glu Lys Leu Leu Gln Ala Asn Lys Leu His Asn Gln Gly Glu
         685                 690                 695

 gtg gag gat att ttc ttc gat tct cac tct gtc aat gct cac ata ccg     2344
 Val Glu Asp Ile Phe Phe Asp Ser His Ser Val Asn Ala His Ile Pro
     700                 705                 710

 cag ttt aga agc act ctt ccg act ggt att cag gta aag gaa aac cag     2392
 Gln Phe Arg Ser Thr Leu Pro Thr Gly Ile Gln Val Lys Glu Asn Gln
 715                 720                 725                 730

 cct gtg ggt tcc agt gta att ttc atg aac tcc act gac ctt gac act     2440
 Pro Val Gly Ser Ser Val Ile Phe Met Asn Ser Thr Asp Leu Asp Thr
                 735                 740                 745

 ggc ttc aat gga aaa ctg gtc tat gct gtt tct gga gga aat gag gat     2488
 Gly Phe Asn Gly Lys Leu Val Tyr Ala Val Ser Gly Gly Asn Glu Asp
             750                 755                 760

 agt tgc ttc atg att gat atg gaa aca gga atg ctg aaa att tta tct     2536
 Ser Cys Phe Met Ile Asp Met Glu Thr Gly Met Leu Lys Ile Leu Ser
         765                 770                 775

 cct ctt gac cgt gaa aca aca gac aaa tac acc ctg aat att acc gtc     2584
 Pro Leu Asp Arg Glu Thr Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val
     780                 785                 790

 tat gac ctt ggg ata ccc cag aag gct gcg tgg cgt ctt cta cat gtc     2632
 Tyr Asp Leu Gly Ile Pro Gln Lys Ala Ala Trp Arg Leu Leu His Val
 795                 800                 805                 810

 gtg gtt gtc gat gcc aat gat aat cca ccc gag ttt tta cag gag agc     2680
 Val Val Val Asp Ala Asn Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser
                 815                 820                 825

 tat ttt gtg gaa gtg agt gaa gac aag gag gta cat agt gaa atc atc     2728
 Tyr Phe Val Glu Val Ser Glu Asp Lys Glu Val His Ser Glu Ile Ile
             830                 835                 840

 cag gtt gaa gcc aca gat aaa gac ctg ggg ccc aac gga cac gtg acg     2776
 Gln Val Glu Ala Thr Asp Lys Asp Leu Gly Pro Asn Gly His Val Thr
         845                 850                 855

 tac tca att ctt aca gac aca gac aca ttt tca att gac agc gtg acg     2824
 Tyr Ser Ile Leu Thr Asp Thr Asp Thr Phe Ser Ile Asp Ser Val Thr
     860                 865                 870

 ggt gtt gtt aac atc gca cgc cct ctg gat cga gag ctg cag cat gag     2872
 Gly Val Val Asn Ile Ala Arg Pro Leu Asp Arg Glu Leu Gln His Glu
 875                 880                 885                 890

 cac tcc tta aag att gag gcc agg gac caa gcc aga gaa gag cct cag     2920
 His Ser Leu Lys Ile Glu Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln
                 895                 900                 905

 ctg ttc tcc act gtc gtt gtg aaa gta tca cta gaa gat gtt aat gac     2968
 Leu Phe Ser Thr Val Val Val Lys Val Ser Leu Glu Asp Val Asn Asp
             910                 915                 920

 aac cca cct aca ttt att cca cct aat tat cgt gtg aaa gtc cga gag     3016
 Asn Pro Pro Thr Phe Ile Pro Pro Asn Tyr Arg Val Lys Val Arg Glu
         925                 930                 935

 gat ctt cca gaa gga acc gtc atc atg tgg tta gaa gcc cac gat cct     3064
 Asp Leu Pro Glu Gly Thr Val Ile Met Trp Leu Glu Ala His Asp Pro
     940                 945                 950

 gat tta ggt cag tct ggt cag gtg aga tac agc ctt ctg gac cac gga     3112
 Asp Leu Gly Gln Ser Gly Gln Val Arg Tyr Ser Leu Leu Asp His Gly
 955                 960                 965                 970

 gaa gga aac ttc gat gtg gat aaa ctc agt gga gca gtt agg atc gtc     3160
 Glu Gly Asn Phe Asp Val Asp Lys Leu Ser Gly Ala Val Arg Ile Val
                 975                 980                 985

 cag cag ttg gac ttt gag aag aag caa gtg tat aat ctc act gtg agg     3208
 Gln Gln Leu Asp Phe Glu Lys Lys Gln Val Tyr Asn Leu Thr Val Arg
             990                 995                1000

 gcc aaa gac aag gga aag cca gtt tct ctg tct tct act tgc tat gtt     3256
 Ala Lys Asp Lys Gly Lys Pro Val Ser Leu Ser Ser Thr Cys Tyr Val
        1005                1010                1015

 gaa gtt gag gtg gtt gat gtg aat gag aac ctg cac cca ccc gtg ttt     3304
 Glu Val Glu Val Val Asp Val Asn Glu Asn Leu His Pro Pro Val Phe
    1020                1025                1030

 tcc agc ttt gtg gaa aag ggg aca gtg aaa gaa gat gca cct gtt ggt     3352
 Ser Ser Phe Val Glu Lys Gly Thr Val Lys Glu Asp Ala Pro Val Gly
1035                1040                1045                1050

 tca ttg gta atg acg gtg tcg gct cat gat gag gac gcc gga aga gat     3400
 Ser Leu Val Met Thr Val Ser Ala His Asp Glu Asp Ala Gly Arg Asp
                1055                1060                1065

 ggg gag atc cga tac tcc att aga gat ggc tct ggc gtt ggt gtt ttc     3448
 Gly Glu Ile Arg Tyr Ser Ile Arg Asp Gly Ser Gly Val Gly Val Phe
            1070                1075                1080

 aaa ata ggt gaa gag aca ggt gtc ata gag acg tca gat cga ctg gac     3496
 Lys Ile Gly Glu Glu Thr Gly Val Ile Glu Thr Ser Asp Arg Leu Asp
        1085                1090                1095

 cgt gaa tcg acc tcc cat tat tgg cta aca gtc ttt gca acc gat cag     3544
 Arg Glu Ser Thr Ser His Tyr Trp Leu Thr Val Phe Ala Thr Asp Gln
    1100                1105                1110

 ggt gtc gtg cct ctt tca tcg ttc ata gag atc tac ata gag gtt gag     3592
 Gly Val Val Pro Leu Ser Ser Phe Ile Glu Ile Tyr Ile Glu Val Glu
1115                1120                1125                1130

 gat gtc aat gac aat gca cca cag aca tca gag cct gtt tat tac cca     3640
 Asp Val Asn Asp Asn Ala Pro Gln Thr Ser Glu Pro Val Tyr Tyr Pro
                1135                1140                1145

 gaa atc atg gaa aat tct cct aaa gat gta tct gtg gtc cag atc gag     3688
 Glu Ile Met Glu Asn Ser Pro Lys Asp Val Ser Val Val Gln Ile Glu
            1150                1155                1160

 gca ttt gat cca gat tcg agc tct aat gac aag ctc atg tac aaa att     3736
 Ala Phe Asp Pro Asp Ser Ser Ser Asn Asp Lys Leu Met Tyr Lys Ile
        1165                1170                1175

 aca agt gga aat cca caa gga ttc ttt tca ata cat cct aaa aca ggt     3784
 Thr Ser Gly Asn Pro Gln Gly Phe Phe Ser Ile His Pro Lys Thr Gly
    1180                1185                1190

 ctc atc aca act acg tca agg aag cta gac cga gaa cag caa gat gaa     3832
 Leu Ile Thr Thr Thr Ser Arg Lys Leu Asp Arg Glu Gln Gln Asp Glu
1195                1200                1205                1210

 cac ata tta gag gtt act gtg aca gac aat ggt agt ccc ccc aaa tca     3880
 His Ile Leu Glu Val Thr Val Thr Asp Asn Gly Ser Pro Pro Lys Ser
                1215                1220                1225

 acc att gca aga gtc att gtg aaa atc ctt gat gaa aat gac aac aaa     3928
 Thr Ile Ala Arg Val Ile Val Lys Ile Leu Asp Glu Asn Asp Asn Lys
            1230                1235                1240

 cct cag ttt ctg caa aag ttc tac aaa atc aga ctc cct gag cgg gaa     3976
 Pro Gln Phe Leu Gln Lys Phe Tyr Lys Ile Arg Leu Pro Glu Arg Glu
        1245                1250                1255

 aag cca gac cga gaa aga aat gcc aga cgg gag ccg ctc tat cgc gtc     4024
 Lys Pro Asp Arg Glu Arg Asn Ala Arg Arg Glu Pro Leu Tyr Arg Val
    1260                1265                1270

 ata gcc acc gac aag gat gag ggc ccc aat gca gaa atc tcc tac agc     4072
 Ile Ala Thr Asp Lys Asp Glu Gly Pro Asn Ala Glu Ile Ser Tyr Ser
1275                1280                1285                1290

 atc gaa gac ggg aat gag cat ggc aaa ttt ttc atc gaa ccg aaa act     4120
 Ile Glu Asp Gly Asn Glu His Gly Lys Phe Phe Ile Glu Pro Lys Thr
                1295                1300                1305

 gga gtg gtt tcg tcc aag agg ttt tca gca gct gga gaa tat gat att     4168
 Gly Val Val Ser Ser Lys Arg Phe Ser Ala Ala Gly Glu Tyr Asp Ile
            1310                1315                1320

 ctt tca att aag gca gtt gac aat ggt cgc cct caa aag tca tca acc     4216
 Leu Ser Ile Lys Ala Val Asp Asn Gly Arg Pro Gln Lys Ser Ser Thr
        1325                1330                1335

 acc aga ctc cat att gaa tgg atc tcc aag ccc aaa cag tcc ctg gag     4264
 Thr Arg Leu His Ile Glu Trp Ile Ser Lys Pro Lys Gln Ser Leu Glu
    1340                1345                1350

 ccc att tca ttt gaa gaa tca ttt ttt acc ttt act gtg atg gaa agt     4312
 Pro Ile Ser Phe Glu Glu Ser Phe Phe Thr Phe Thr Val Met Glu Ser
1355                1360                1365                1370

 gac ccc gtt gct cac atg att gga gta ata tct gtg gag cct cct ggc     4360
 Asp Pro Val Ala His Met Ile Gly Val Ile Ser Val Glu Pro Pro Gly
                1375                1380                1385

 ata ccc ctt tgg ttt gac atc act ggt ggc aac tac gac agt cac ttc     4408
 Ile Pro Leu Trp Phe Asp Ile Thr Gly Gly Asn Tyr Asp Ser His Phe
            1390                1395                1400

 gat gtg gac aag gga act gga acc atc att gtt gcc aaa cct ctt gat     4456
 Asp Val Asp Lys Gly Thr Gly Thr Ile Ile Val Ala Lys Pro Leu Asp
        1405                1410                1415

 gca gaa cag aag tca aac tac aac ctc aca gtc gag gct aca gat gga     4504
 Ala Glu Gln Lys Ser Asn Tyr Asn Leu Thr Val Glu Ala Thr Asp Gly
    1420                1425                1430

 acc acc act atc ctc act cag gta ttc atc aaa gta ata gac aca aat     4552
 Thr Thr Thr Ile Leu Thr Gln Val Phe Ile Lys Val Ile Asp Thr Asn
1435                1440                1445                1450

 gac cat cgt cct cag ttt tct aca tca aag tat gaa gtt gtt att cct     4600
 Asp His Arg Pro Gln Phe Ser Thr Ser Lys Tyr Glu Val Val Ile Pro
                1455                1460                1465

 gaa gat aca gcg cca gaa aca gaa att ttg caa atc agt gct gtg gat     4648
 Glu Asp Thr Ala Pro Glu Thr Glu Ile Leu Gln Ile Ser Ala Val Asp
            1470                1475                1480

 cag gat gag aaa aac aaa cta atc tac act ctg cag agc agt aga gat     4696
 Gln Asp Glu Lys Asn Lys Leu Ile Tyr Thr Leu Gln Ser Ser Arg Asp
        1485                1490                1495

 cca ctg agt ctc aag aaa ttt cgt ctt gat cct gca acc ggc tct ctc     4744
 Pro Leu Ser Leu Lys Lys Phe Arg Leu Asp Pro Ala Thr Gly Ser Leu
    1500                1505                1510

 tat act tct gag aaa ctg gat cat gaa gct gtt tca cca gca cac ctc     4792
 Tyr Thr Ser Glu Lys Leu Asp His Glu Ala Val Ser Pro Ala His Leu
1515                1520                1525                1530

 acg gtc atg gta cga gat caa gat gtg cct gta aaa cgc aac ttt gca     4840
 Thr Val Met Val Arg Asp Gln Asp Val Pro Val Lys Arg Asn Phe Ala
                1535                1540                1545

 agg att gtg gtc aat gtc agc gac acg aat gac cac gcc ccg tgg ttc     4888
 Arg Ile Val Val Asn Val Ser Asp Thr Asn Asp His Ala Pro Trp Phe
            1550                1555                1560

 acc gct tcc tcc tac aaa ggg cgg gtt tat gaa tcg gca gcc gtt ggc     4936
 Thr Ala Ser Ser Tyr Lys Gly Arg Val Tyr Glu Ser Ala Ala Val Gly
        1565                1570                1575

 tca gtt gtg ttg cag gtg acg gct ctg gac aag gac aaa ggg aaa aat     4984
 Ser Val Val Leu Gln Val Thr Ala Leu Asp Lys Asp Lys Gly Lys Asn
    1580                1585                1590

 gct gaa gtg ctg tac tcg atc gag tca gga aat att gga aat att gga     5032
 Ala Glu Val Leu Tyr Ser Ile Glu Ser Gly Asn Ile Gly Asn Ile Gly
1595                1600                1605                1610

 aat tct ttt atg att gat cct gtc ttg ggc tct att aaa act gcc aaa     5080
 Asn Ser Phe Met Ile Asp Pro Val Leu Gly Ser Ile Lys Thr Ala Lys
                1615                1620                1625

 gaa tta gat cga agt aac caa gcg gag tat gat tta atg gta aaa gct     5128
 Glu Leu Asp Arg Ser Asn Gln Ala Glu Tyr Asp Leu Met Val Lys Ala
            1630                1635                1640

 aca gat aag ggc agt cca cca atg agt gaa ata act tct gtg cgt atc     5176
 Thr Asp Lys Gly Ser Pro Pro Met Ser Glu Ile Thr Ser Val Arg Ile
        1645                1650                1655

 ttt gtc aca att gct gac aac gcc tct ccg aag ttt aca tca aaa gaa     5224
 Phe Val Thr Ile Ala Asp Asn Ala Ser Pro Lys Phe Thr Ser Lys Glu
    1660                1665                1670

 tat tct gtt gaa ctt agt gaa act gtc agc att ggg agt ttc gtt ggg     5272
 Tyr Ser Val Glu Leu Ser Glu Thr Val Ser Ile Gly Ser Phe Val Gly
1675                1680                1685                1690

 atg gtt aca gcc cat agt caa tca tca gtg gtg tat gaa ata aaa gat     5320
 Met Val Thr Ala His Ser Gln Ser Ser Val Val Tyr Glu Ile Lys Asp
                1695                1700                1705

 gga aat aca ggt gat gct ttt gat att aat cca cat tct gga act atc     5368
 Gly Asn Thr Gly Asp Ala Phe Asp Ile Asn Pro His Ser Gly Thr Ile
            1710                1715                1720

 atc act cag aaa gcc ctg gac ttt gaa act ttg ccc att tac aca ttg     5416
 Ile Thr Gln Lys Ala Leu Asp Phe Glu Thr Leu Pro Ile Tyr Thr Leu
        1725                1730                1735

 ata ata caa gga act aac atg gct ggt ttg tcc act aat aca acg gtt     5464
 Ile Ile Gln Gly Thr Asn Met Ala Gly Leu Ser Thr Asn Thr Thr Val
    1740                1745                1750

 cta gtt cac ttg cag gat gag aat gac aac gcg cca gtt ttt atg cag     5512
 Leu Val His Leu Gln Asp Glu Asn Asp Asn Ala Pro Val Phe Met Gln
1755                1760                1765                1770

 gca gaa tat aca gga ctc att agt gaa tca gcc tca att aac agc gtg     5560
 Ala Glu Tyr Thr Gly Leu Ile Ser Glu Ser Ala Ser Ile Asn Ser Val
                1775                1780                1785

 gtc cta aca gac agg aat gtc cca ctg gtg att cga gca gct gat gct     5608
 Val Leu Thr Asp Arg Asn Val Pro Leu Val Ile Arg Ala Ala Asp Ala
            1790                1795                1800

 gat aaa gac tca aat gct ttg ctt gta tat cac att gtt gaa cca tct     5656
 Asp Lys Asp Ser Asn Ala Leu Leu Val Tyr His Ile Val Glu Pro Ser
        1805                1810                1815

 gta cac aca tat ttt gct att gat tct agc act ggt gct att cat aca     5704
 Val His Thr Tyr Phe Ala Ile Asp Ser Ser Thr Gly Ala Ile His Thr
    1820                1825                1830

 gta cta agt ctg gac tat gaa gaa aca agt att ttt cac ttt acc gtc     5752
 Val Leu Ser Leu Asp Tyr Glu Glu Thr Ser Ile Phe His Phe Thr Val
1835                1840                1845                1850

 caa gtg cat gac atg gga acc cca cgt tta ttt gct gag tat gca gcg     5800
 Gln Val His Asp Met Gly Thr Pro Arg Leu Phe Ala Glu Tyr Ala Ala
                1855                1860                1865

 aat gta aca gta cat gta att gac att aat gac tgc ccc cct gtg ttt     5848
 Asn Val Thr Val His Val Ile Asp Ile Asn Asp Cys Pro Pro Val Phe
            1870                1875                1880

 gcc aag cca tta tat gaa gca tct ctt ttg tta cca aca tac aaa gga     5896
 Ala Lys Pro Leu Tyr Glu Ala Ser Leu Leu Leu Pro Thr Tyr Lys Gly
        1885                1890                1895

 gta aaa gtc atc aca gta aat gct aca gat gct gat tca agt gca ttc     5944
 Val Lys Val Ile Thr Val Asn Ala Thr Asp Ala Asp Ser Ser Ala Phe
    1900                1905                1910

 tca cag ttg att tac tcc atc acc gaa ggc aac atc ggg gag aag ttt     5992
 Ser Gln Leu Ile Tyr Ser Ile Thr Glu Gly Asn Ile Gly Glu Lys Phe
1915                1920                1925                1930

 tct atg gac tac aag act ggt gct ctc act gtc caa aac aca act cag     6040
 Ser Met Asp Tyr Lys Thr Gly Ala Leu Thr Val Gln Asn Thr Thr Gln
                1935                1940                1945

 tta aga agc cgc tac gag cta acc gtt aga gct tcc gat ggc aga ttt     6088
 Leu Arg Ser Arg Tyr Glu Leu Thr Val Arg Ala Ser Asp Gly Arg Phe
            1950                1955                1960

 gcc ggc ctt acc tct gtc aaa att aat gtg aaa gaa agc aaa gaa agt     6136
 Ala Gly Leu Thr Ser Val Lys Ile Asn Val Lys Glu Ser Lys Glu Ser
        1965                1970                1975

 cac cta aag ttt acc cag gat gtc tac tct gcg gta gtg aaa gag aat     6184
 His Leu Lys Phe Thr Gln Asp Val Tyr Ser Ala Val Val Lys Glu Asn
    1980                1985                1990

 tcc acc gag gcc gaa aca tta gct gtc att act gct att ggg agt cca     6232
 Ser Thr Glu Ala Glu Thr Leu Ala Val Ile Thr Ala Ile Gly Ser Pro
1995                2000                2005                2010

 atc aat gag cct ttg ttt tat cac atc ctc aac cca gat cgc aga ttt     6280
 Ile Asn Glu Pro Leu Phe Tyr His Ile Leu Asn Pro Asp Arg Arg Phe
                2015                2020                2025

 aaa ata agc cgc act tca ggg gtt ctg tca acc act ggc acg ccc ttc     6328
 Lys Ile Ser Arg Thr Ser Gly Val Leu Ser Thr Thr Gly Thr Pro Phe
            2030                2035                2040

 gat cgt gag cag cag gag gcg ttt gat gtg gtt gta gaa gtg ata gag     6376
 Asp Arg Glu Gln Gln Glu Ala Phe Asp Val Val Val Glu Val Ile Glu
        2045                2050                2055

 gaa cat aag cct tct gca gtg gcc cac gtt gtc gtg aag gtc att gta     6424
 Glu His Lys Pro Ser Ala Val Ala His Val Val Val Lys Val Ile Val
    2060                2065                2070

 gaa gac caa aat gat aat gcg ccg gtg ttt gtc aac ctt ccc tac tac     6472
 Glu Asp Gln Asn Asp Asn Ala Pro Val Phe Val Asn Leu Pro Tyr Tyr
2075                2080                2085                2090

 gcc gtt gtt aaa gtg gac act gag gtg ggc cat gtc att cgc tat gtc     6520
 Ala Val Val Lys Val Asp Thr Glu Val Gly His Val Ile Arg Tyr Val
                2095                2100                2105

 act gct gta gac aga gac agt ggc aga aac ggg gaa gtg cat tac tac     6568
 Thr Ala Val Asp Arg Asp Ser Gly Arg Asn Gly Glu Val His Tyr Tyr
            2110                2115                2120

 ctc aag gaa cat cat gaa cac ttt caa att gga ccc ttg ggt gaa att     6616
 Leu Lys Glu His His Glu His Phe Gln Ile Gly Pro Leu Gly Glu Ile
        2125                2130                2135

 tca ctg aaa aag caa ttt gag ctt gac acc tta aat aaa gaa tat ctt     6664
 Ser Leu Lys Lys Gln Phe Glu Leu Asp Thr Leu Asn Lys Glu Tyr Leu
    2140                2145                2150

 gtt aca gtg gtt gca aaa gat gga ggg aac ccg gcc ttt tca gcg gaa     6712
 Val Thr Val Val Ala Lys Asp Gly Gly Asn Pro Ala Phe Ser Ala Glu
2155                2160                2165                2170

 gtt atc gtt ccg atc act gtc atg aat aaa gcc atg cct gtg ttt gaa     6760
 Val Ile Val Pro Ile Thr Val Met Asn Lys Ala Met Pro Val Phe Glu
                2175                2180                2185

 aaa cct ttc tac agt gca gag att gca gag agc atc cag gtg cac agc     6808
 Lys Pro Phe Tyr Ser Ala Glu Ile Ala Glu Ser Ile Gln Val His Ser
            2190                2195                2200

 cct gtg gtc cac gtg cag gct aac agc ccg gaa ggc ctg aaa gtg ttc     6856
 Pro Val Val His Val Gln Ala Asn Ser Pro Glu Gly Leu Lys Val Phe
        2205                2210                2215

 tac agc atc aca gac gga gac cct ttc agc cag ttc act att aac ttc     6904
 Tyr Ser Ile Thr Asp Gly Asp Pro Phe Ser Gln Phe Thr Ile Asn Phe
    2220                2225                2230

 aat act gga gtt atc aat gtc ata gct cct ctg gac ttt gag gcc cac     6952
 Asn Thr Gly Val Ile Asn Val Ile Ala Pro Leu Asp Phe Glu Ala His
2235                2240                2245                2250

 ccg gca tat aag ctg agc ata cgc gca act gac tcc ttg acg ggc gct     7000
 Pro Ala Tyr Lys Leu Ser Ile Arg Ala Thr Asp Ser Leu Thr Gly Ala
                2255                2260                2265

 cat gct gaa gta ttt gtg gac atc ata gta gac gac atc aat gat aac     7048
 His Ala Glu Val Phe Val Asp Ile Ile Val Asp Asp Ile Asn Asp Asn
            2270                2275                2280

 cct cct gtg ttt gct cag cag tct tat gcg gtg acc ctg tct gag gca     7096
 Pro Pro Val Phe Ala Gln Gln Ser Tyr Ala Val Thr Leu Ser Glu Ala
        2285                2290                2295

 tct gta att gga acg tct gtt gtt caa gtt aga gcc acc gat tct gat     7144
 Ser Val Ile Gly Thr Ser Val Val Gln Val Arg Ala Thr Asp Ser Asp
    2300                2305                2310

 tca gaa cca aat aga gga atc tca tac cag atg ttt ggg aat cac agc     7192
 Ser Glu Pro Asn Arg Gly Ile Ser Tyr Gln Met Phe Gly Asn His Ser
2315                2320                2325                2330

 aag agt cat gat cat ttt cat gta gac agc agc act ggc ctc atc tca     7240
 Lys Ser His Asp His Phe His Val Asp Ser Ser Thr Gly Leu Ile Ser
                2335                2340                2345

 cta ctc aga acc ctg gat tac gag cag tcc cgg cag cac acg att ttt     7288
 Leu Leu Arg Thr Leu Asp Tyr Glu Gln Ser Arg Gln His Thr Ile Phe
            2350                2355                2360

 gtg agg gca gtt gat ggt ggt atg ccc acg ctg agc agt gat gtg att     7336
 Val Arg Ala Val Asp Gly Gly Met Pro Thr Leu Ser Ser Asp Val Ile
        2365                2370                2375

 gtc acg gtg gac gtt acc gac ctc aat ggt aat cca cca ctc ttt gaa     7384
 Val Thr Val Asp Val Thr Asp Leu Asn Gly Asn Pro Pro Leu Phe Glu
    2380                2385                2390

 caa cag att tat gaa gcc aga att agc gag cac gcc cct cat ggg cat     7432
 Gln Gln Ile Tyr Glu Ala Arg Ile Ser Glu His Ala Pro His Gly His
2395                2400                2405                2410

 ttc gtg acc tgt gta aaa gcc tat gat gca gac agt tca gac ata gac     7480
 Phe Val Thr Cys Val Lys Ala Tyr Asp Ala Asp Ser Ser Asp Ile Asp
                2415                2420                2425

 aag ttg cag tat tcc att ctg tct ggc aat gat cat aaa cat ttt gtc     7528
 Lys Leu Gln Tyr Ser Ile Leu Ser Gly Asn Asp His Lys His Phe Val
            2430                2435                2440

 att gac agt gca aca ggg att atc acc ctc tca aac ctg cac cgg cac     7576
 Ile Asp Ser Ala Thr Gly Ile Ile Thr Leu Ser Asn Leu His Arg His
        2445                2450                2455

 gcc ctg aag cca ttt tac agt ctt aac ctg tca gtg tct gat gga gtt     7624
 Ala Leu Lys Pro Phe Tyr Ser Leu Asn Leu Ser Val Ser Asp Gly Val
    2460                2465                2470

 ttt aga agt tcc acc cag gtt cat gta act gta att gga ggc aat ttg     7672
 Phe Arg Ser Ser Thr Gln Val His Val Thr Val Ile Gly Gly Asn Leu
2475                2480                2485                2490

 cac agt cct gct ttc ctt cag aac gaa tat gaa gtg gaa cta gct gaa     7720
 His Ser Pro Ala Phe Leu Gln Asn Glu Tyr Glu Val Glu Leu Ala Glu
                2495                2500                2505

 aac gct ccc cta cat acc ctg gtg atg gag gtg aaa act acg gat ggg     7768
 Asn Ala Pro Leu His Thr Leu Val Met Glu Val Lys Thr Thr Asp Gly
            2510                2515                2520

 gat tct ggt att tat ggt cac gtt act tac cat att gta aat gac ttt     7816
 Asp Ser Gly Ile Tyr Gly His Val Thr Tyr His Ile Val Asn Asp Phe
        2525                2530                2535

 gcc aaa gac aga ttt tac ata aat gag aga gga cag ata ttt act ttg     7864
 Ala Lys Asp Arg Phe Tyr Ile Asn Glu Arg Gly Gln Ile Phe Thr Leu
    2540                2545                2550

 gaa aaa ctt gat cga gaa acc ccg gcg gag aaa gtg atc tca gtc cgt     7912
 Glu Lys Leu Asp Arg Glu Thr Pro Ala Glu Lys Val Ile Ser Val Arg
2555                2560                2565                2570

 tta atg gct aag gat gct gga gga aaa gtt gct ttc tgc acc gtg aat     7960
 Leu Met Ala Lys Asp Ala Gly Gly Lys Val Ala Phe Cys Thr Val Asn
                2575                2580                2585

 gtc atc ctt aca gat gac aat gac aat gca cca caa ttt cga gca acc     8008
 Val Ile Leu Thr Asp Asp Asn Asp Asn Ala Pro Gln Phe Arg Ala Thr
            2590                2595                2600

 aaa tac gaa gtg aat atc ggg tcc agt gct gct aaa ggg act tca gtc     8056
 Lys Tyr Glu Val Asn Ile Gly Ser Ser Ala Ala Lys Gly Thr Ser Val
        2605                2610                2615

 gta aag tct gca agt gat gcc gat gag ggc tcc aat gcc gac atc acc     8104
 Val Lys Ser Ala Ser Asp Ala Asp Glu Gly Ser Asn Ala Asp Ile Thr
    2620                2625                2630

 tat gcc att gaa gca gac tct gaa agt gta aaa gag aat ttg gaa att     8152
 Tyr Ala Ile Glu Ala Asp Ser Glu Ser Val Lys Glu Asn Leu Glu Ile
2635                2640                2645                2650

 aac aaa ctg tcc ggc gta atc act aca aag gag agc ctc att ggc ttg     8200
 Asn Lys Leu Ser Gly Val Ile Thr Thr Lys Glu Ser Leu Ile Gly Leu
                2655                2660                2665

 gaa aat gaa ttc ttc act ttc ttt gtt aga gct gtg gat aat ggg tct     8248
 Glu Asn Glu Phe Phe Thr Phe Phe Val Arg Ala Val Asp Asn Gly Ser
            2670                2675                2680

 cca tca aaa gaa tct gtt gtt ctt gtc tat gtt aaa atc ctt cca ccg     8296
 Pro Ser Lys Glu Ser Val Val Leu Val Tyr Val Lys Ile Leu Pro Pro
        2685                2690                2695

 gaa atg cag ctt cca aaa ttt tca gaa cct ttc tat acc ttt aca gtg     8344
 Glu Met Gln Leu Pro Lys Phe Ser Glu Pro Phe Tyr Thr Phe Thr Val
    2700                2705                2710

 tca gag gac gtg cct gtt gga aca gag ata gat ctc atc cga gca gaa     8392
 Ser Glu Asp Val Pro Val Gly Thr Glu Ile Asp Leu Ile Arg Ala Glu
2715                2720                2725                2730

 cat agt ggg act gtt ctt tac agc ctg gtc aaa ggg aat act cca gaa     8440
 His Ser Gly Thr Val Leu Tyr Ser Leu Val Lys Gly Asn Thr Pro Glu
                2735                2740                2745

 agc aat agg gat gag tcc ttt gtg att gac aga cag agc ggg aga ctg     8488
 Ser Asn Arg Asp Glu Ser Phe Val Ile Asp Arg Gln Ser Gly Arg Leu
            2750                2755                2760

 aag ttg gag aag agt ctt gat cat gag aca act aag tgg tat cag ttt     8536
 Lys Leu Glu Lys Ser Leu Asp His Glu Thr Thr Lys Trp Tyr Gln Phe
        2765                2770                2775

 tcc ata ctg gcc agg tgc act caa gat gac cat gag atg gtg gct tct     8584
 Ser Ile Leu Ala Arg Cys Thr Gln Asp Asp His Glu Met Val Ala Ser
    2780                2785                2790

 gta gat gtt agt atc caa gtg aaa gat gca aat gac aac agc ccg gtc     8632
 Val Asp Val Ser Ile Gln Val Lys Asp Ala Asn Asp Asn Ser Pro Val
2795                2800                2805                2810

 ttt gaa tct agt cca tat gag gca ttc att gtt gaa aac ctg cca ggg     8680
 Phe Glu Ser Ser Pro Tyr Glu Ala Phe Ile Val Glu Asn Leu Pro Gly
                2815                2820                2825

 gga agt aga gta att cag atc agg gca tct gat gct gac tca gga acc     8728
 Gly Ser Arg Val Ile Gln Ile Arg Ala Ser Asp Ala Asp Ser Gly Thr
            2830                2835                2840

 aac ggc caa gtt atg tat agc ctg gat cag tca caa agt gtg gaa gtc     8776
 Asn Gly Gln Val Met Tyr Ser Leu Asp Gln Ser Gln Ser Val Glu Val
        2845                2850                2855

 att gaa tcc ttt gcc att aac atg gaa aca ggc tgg att aca act tta     8824
 Ile Glu Ser Phe Ala Ile Asn Met Glu Thr Gly Trp Ile Thr Thr Leu
    2860                2865                2870

 aag gaa ctt gac cat gaa aag aga gac aat tac cag att aaa gtg gtt     8872
 Lys Glu Leu Asp His Glu Lys Arg Asp Asn Tyr Gln Ile Lys Val Val
2875                2880                2885                2890

 gca tca gat cat ggt gaa aag atc cag cta tcc tcc aca gcc att gtg     8920
 Ala Ser Asp His Gly Glu Lys Ile Gln Leu Ser Ser Thr Ala Ile Val
                2895                2900                2905

 gat gtt acc gtc acc gat gtc aac gat agt cca cca cga ttc acg gcc     8968
 Asp Val Thr Val Thr Asp Val Asn Asp Ser Pro Pro Arg Phe Thr Ala
            2910                2915                2920

 gag atc tat aaa ggg act gtg agt gag gat gac ccc caa ggt ggg gtg     9016
 Glu Ile Tyr Lys Gly Thr Val Ser Glu Asp Asp Pro Gln Gly Gly Val
        2925                2930                2935

 att gcc atc tta agt acc acg gat gct gat tct gaa gag atc aac aga     9064
 Ile Ala Ile Leu Ser Thr Thr Asp Ala Asp Ser Glu Glu Ile Asn Arg
    2940                2945                2950

 caa gtt aca tat ttc ata aca gga ggg gat cct tta gga cag ttt gcc     9112
 Gln Val Thr Tyr Phe Ile Thr Gly Gly Asp Pro Leu Gly Gln Phe Ala
2955                2960                2965                2970

 gtt gaa act ata cag aat gaa tgg aag gta tat gtg aag aaa cct cta     9160
 Val Glu Thr Ile Gln Asn Glu Trp Lys Val Tyr Val Lys Lys Pro Leu
                2975                2980                2985

 gac agg gaa aaa agg gac aat tac ctt ctt act atc acg gca act gat     9208
 Asp Arg Glu Lys Arg Asp Asn Tyr Leu Leu Thr Ile Thr Ala Thr Asp
            2990                2995                3000

 ggc acc ttc tca tca aaa gcg ata gtt gaa gtg aaa gtt ctg gat gca     9256
 Gly Thr Phe Ser Ser Lys Ala Ile Val Glu Val Lys Val Leu Asp Ala
        3005                3010                3015

 aat gac aac agt cca gtt tgt gaa aag act tta tat tca gac act att     9304
 Asn Asp Asn Ser Pro Val Cys Glu Lys Thr Leu Tyr Ser Asp Thr Ile
    3020                3025                3030

 cct gaa gac gtc ctt cct gga aaa ttg atc atg cag atc tct gct aca     9352
 Pro Glu Asp Val Leu Pro Gly Lys Leu Ile Met Gln Ile Ser Ala Thr
3035                3040                3045                3050

 gac gca gac atc cgc tct aac gct gaa att act tac acg tta ttg ggt     9400
 Asp Ala Asp Ile Arg Ser Asn Ala Glu Ile Thr Tyr Thr Leu Leu Gly
                3055                3060                3065

 tca ggt gca gaa aaa ttc aaa cta aat cca gac aca ggt gaa ctg aaa     9448
 Ser Gly Ala Glu Lys Phe Lys Leu Asn Pro Asp Thr Gly Glu Leu Lys
            3070                3075                3080

 acg tca acc ccc ctt gat cgt gag gag caa gct gtt tat cat ctt ctc     9496
 Thr Ser Thr Pro Leu Asp Arg Glu Glu Gln Ala Val Tyr His Leu Leu
        3085                3090                3095

 gtc agg gcc aca gat gga gga gga aga ttc tgc caa gcc agt att gtc     9544
 Val Arg Ala Thr Asp Gly Gly Gly Arg Phe Cys Gln Ala Ser Ile Val
    3100                3105                3110

 gtc acg cta gaa gat gtg aac gat aac gcc ccc gaa ttc tct gcc gat     9592
 Val Thr Leu Glu Asp Val Asn Asp Asn Ala Pro Glu Phe Ser Ala Asp
3115                3120                3125                3130

 cct tat gcc atc acc gtg ttt gaa aac aca gag ccg gga acg ctg ctg     9640
 Pro Tyr Ala Ile Thr Val Phe Glu Asn Thr Glu Pro Gly Thr Leu Leu
                3135                3140                3145

 aca aga gtg cag gcc aca gat gcc gac gca gga tta aat cgg aag att     9688
 Thr Arg Val Gln Ala Thr Asp Ala Asp Ala Gly Leu Asn Arg Lys Ile
            3150                3155                3160

 tta tac tca ctg att gac tct gct gat ggg cag ttc tcc att aac gaa     9736
 Leu Tyr Ser Leu Ile Asp Ser Ala Asp Gly Gln Phe Ser Ile Asn Glu
        3165                3170                3175

 tta tct gga att att cag tta gaa aaa cct ttg gac aga gaa ctc cag     9784
 Leu Ser Gly Ile Ile Gln Leu Glu Lys Pro Leu Asp Arg Glu Leu Gln
    3180                3185                3190

 gca gta tac acc ctc tct ttg aaa gct gtg gat caa ggc ttg cca agg     9832
 Ala Val Tyr Thr Leu Ser Leu Lys Ala Val Asp Gln Gly Leu Pro Arg
3195                3200                3205                3210

 agg ctg act gcc act ggc act gtg att gta tca gtt ctt gac ata aat     9880
 Arg Leu Thr Ala Thr Gly Thr Val Ile Val Ser Val Leu Asp Ile Asn
                3215                3220                3225

 gac aac ccc cct gtg ttt gag tac cgt gaa tat ggt gcc acc gtg tct     9928
 Asp Asn Pro Pro Val Phe Glu Tyr Arg Glu Tyr Gly Ala Thr Val Ser
            3230                3235                3240

 gag gac att ctt gtt gga act gaa gtt ctt caa gtg tat gca gca agt     9976
 Glu Asp Ile Leu Val Gly Thr Glu Val Leu Gln Val Tyr Ala Ala Ser
        3245                3250                3255

 cgg gat att gaa gca aat gca gaa atc acc tac tca ata ata agt gga    10024
 Arg Asp Ile Glu Ala Asn Ala Glu Ile Thr Tyr Ser Ile Ile Ser Gly
    3260                3265                3270

 aat gaa cat ggg aaa ttc agc ata gat tct aaa aca ggg gcc gta ttt    10072
 Asn Glu His Gly Lys Phe Ser Ile Asp Ser Lys Thr Gly Ala Val Phe
3275                3280                3285                3290

 atc att gag aat ctg gat tat gag agc tct cat gag tat tac cta aca    10120
 Ile Ile Glu Asn Leu Asp Tyr Glu Ser Ser His Glu Tyr Tyr Leu Thr
                3295                3300                3305

 gta gag gcc act gat gga ggc acg cct tca ctg agc gac gtt gcc act    10168
 Val Glu Ala Thr Asp Gly Gly Thr Pro Ser Leu Ser Asp Val Ala Thr
            3310                3315                3320

 gtg aac gtt aat gta aca gat atc aac gat aat acc cct gtg ttc agc    10216
 Val Asn Val Asn Val Thr Asp Ile Asn Asp Asn Thr Pro Val Phe Ser
        3325                3330                3335

 caa gac acc tac acg aca gtc atc agt gaa gat gcc gtt ctt gag cag    10264
 Gln Asp Thr Tyr Thr Thr Val Ile Ser Glu Asp Ala Val Leu Glu Gln
    3340                3345                3350

 tct gtc atc acg gtt atg gcc gat gat gcc gat gga cct tcc aac agc    10312
 Ser Val Ile Thr Val Met Ala Asp Asp Ala Asp Gly Pro Ser Asn Ser
3355                3360                3365                3370

 cac atc cac tac tca att ata gat ggc aac caa gga agc tcg ttc aca    10360
 His Ile His Tyr Ser Ile Ile Asp Gly Asn Gln Gly Ser Ser Phe Thr
                3375                3380                3385

 att gac ccc gtc agg gga gaa gtc aaa gtg acc aaa ctt ctc gac cga    10408
 Ile Asp Pro Val Arg Gly Glu Val Lys Val Thr Lys Leu Leu Asp Arg
            3390                3395                3400

 gaa acg att tca ggt tac acg ctc acg gtt caa gct tct gat aat ggc    10456
 Glu Thr Ile Ser Gly Tyr Thr Leu Thr Val Gln Ala Ser Asp Asn Gly
        3405                3410                3415

 agt cca ccc aga gtc aac acg acg acc gtg aac atc gat gtg tcc gat    10504
 Ser Pro Pro Arg Val Asn Thr Thr Thr Val Asn Ile Asp Val Ser Asp
    3420                3425                3430

 gtc aat gac aac gcg ccc gtc ttc tcc agg gga aac tac agt gtc att    10552
 Val Asn Asp Asn Ala Pro Val Phe Ser Arg Gly Asn Tyr Ser Val Ile
3435                3440                3445                3450

 atc cag gaa aat aag cca gtg ggc ttc agc gtg ctg cag ctg gta gta    10600
 Ile Gln Glu Asn Lys Pro Val Gly Phe Ser Val Leu Gln Leu Val Val
                3455                3460                3465

 aca gat gag gat tct tcc cat aac ggt cca ccc ttc ttc ttt act att    10648
 Thr Asp Glu Asp Ser Ser His Asn Gly Pro Pro Phe Phe Phe Thr Ile
            3470                3475                3480

 gta act gga aat gat gag aag gct ttt gaa gtt aac ccg caa gga gtc    10696
 Val Thr Gly Asn Asp Glu Lys Ala Phe Glu Val Asn Pro Gln Gly Val
        3485                3490                3495

 ctc ctg aca tca tct gcc atc aag agg aag gag aaa gat cat tac tta    10744
 Leu Leu Thr Ser Ser Ala Ile Lys Arg Lys Glu Lys Asp His Tyr Leu
    3500                3505                3510

 ctg cag gtg aag gtg gca gat aat gga aag cct cag ttg tca tct ttg    10792
 Leu Gln Val Lys Val Ala Asp Asn Gly Lys Pro Gln Leu Ser Ser Leu
3515                3520                3525                3530

 aca tac att gac att agg gta att gag gag agc atc tat ccg cct gcg    10840
 Thr Tyr Ile Asp Ile Arg Val Ile Glu Glu Ser Ile Tyr Pro Pro Ala
                3535                3540                3545

 att ttg ccc ctg gag att ttc atc acc tct tct gga gaa gaa tac tca    10888
 Ile Leu Pro Leu Glu Ile Phe Ile Thr Ser Ser Gly Glu Glu Tyr Ser
            3550                3555                3560

 ggt ggc gtc att ggg aag atc cat gcc aca gac cag gac gtg tat gat    10936
 Gly Gly Val Ile Gly Lys Ile His Ala Thr Asp Gln Asp Val Tyr Asp
        3565                3570                3575

 act cta acc tac agt ctc gac cct cag atg gac aac ctg ttc tct gtt    10984
 Thr Leu Thr Tyr Ser Leu Asp Pro Gln Met Asp Asn Leu Phe Ser Val
    3580                3585                3590

 tcc agc aca ggg ggc aag ctg ata gca cac aaa aag cta gac ata ggg    11032
 Ser Ser Thr Gly Gly Lys Leu Ile Ala His Lys Lys Leu Asp Ile Gly
3595                3600                3605                3610

 caa tac ctt ctc aat gtc agc gta aca gat ggg aag ttc acg acg gtg    11080
 Gln Tyr Leu Leu Asn Val Ser Val Thr Asp Gly Lys Phe Thr Thr Val
                3615                3620                3625

 gcc gac atc aca gtg cat atc aga caa gtc aca cag gag atg ttg aac    11128
 Ala Asp Ile Thr Val His Ile Arg Gln Val Thr Gln Glu Met Leu Asn
            3630                3635                3640

 cac acc atc gcg atc cgc ttt gcc aac ctc act ccg gaa gaa ttc gtt    11176
 His Thr Ile Ala Ile Arg Phe Ala Asn Leu Thr Pro Glu Glu Phe Val
        3645                3650                3655

 ggt gac tac tgg cgc aac ttc cag cga gct tta cgg aac atc ctg ggt    11224
 Gly Asp Tyr Trp Arg Asn Phe Gln Arg Ala Leu Arg Asn Ile Leu Gly
    3660                3665                3670

 gtg agg agg aac gac ata cag att gtt agt ttg cag tcc tct gaa cct    11272
 Val Arg Arg Asn Asp Ile Gln Ile Val Ser Leu Gln Ser Ser Glu Pro
3675                3680                3685                3690

 cac cca cat ctg gac gtc tta ctt ttt gta gag aaa cca ggt agt gct    11320
 His Pro His Leu Asp Val Leu Leu Phe Val Glu Lys Pro Gly Ser Ala
                3695                3700                3705

 cag atc tca aca aaa caa ctt ctg cac aag att aac tct tcc gtg act    11368
 Gln Ile Ser Thr Lys Gln Leu Leu His Lys Ile Asn Ser Ser Val Thr
            3710                3715                3720

 gac att gag gaa atc att gga gtt agg ata ctg aat gta ttc cag aaa    11416
 Asp Ile Glu Glu Ile Ile Gly Val Arg Ile Leu Asn Val Phe Gln Lys
        3725                3730                3735

 ctc tgc gcg gga ctg gac tgc ccc tgg aag ttc tgc gat gaa aag gtg    11464
 Leu Cys Ala Gly Leu Asp Cys Pro Trp Lys Phe Cys Asp Glu Lys Val
    3740                3745                3750

 tct gtg gat gaa agt gtg atg tca aca cac agc aca gcc aga ctg agt    11512
 Ser Val Asp Glu Ser Val Met Ser Thr His Ser Thr Ala Arg Leu Ser
3755                3760                3765                3770

 ttt gtg act ccc cgc cac cac agg gca gcg gtg tgt ctc tgc aaa gag    11560
 Phe Val Thr Pro Arg His His Arg Ala Ala Val Cys Leu Cys Lys Glu
                3775                3780                3785

 gga agg tgc cca cct gtc cac cat ggc tgt gaa gat gat ccg tgc cct    11608
 Gly Arg Cys Pro Pro Val His His Gly Cys Glu Asp Asp Pro Cys Pro
            3790                3795                3800

 gag gga tcc gaa tgt gtg tct gat ccc tgg gag gag aaa cac acc tgt    11656
 Glu Gly Ser Glu Cys Val Ser Asp Pro Trp Glu Glu Lys His Thr Cys
        3805                3810                3815

 gtc tgt ccc agc ggc agg ttt ggt cag tgc cca ggg agt tca tct atg    11704
 Val Cys Pro Ser Gly Arg Phe Gly Gln Cys Pro Gly Ser Ser Ser Met
    3820                3825                3830

 aca ctg act gga aac agc tac gtg aaa tac cgt ctg acg gaa aat gaa    11752
 Thr Leu Thr Gly Asn Ser Tyr Val Lys Tyr Arg Leu Thr Glu Asn Glu
3835                3840                3845                3850

 aac aaa tta gag atg aaa ctg acc atg agg ctc aga aca tat tcc acg    11800
 Asn Lys Leu Glu Met Lys Leu Thr Met Arg Leu Arg Thr Tyr Ser Thr
                3855                3860                3865

 cat gcg gtt gtc atg tat gct cga gga act gac tat agc atc ttg gag    11848
 His Ala Val Val Met Tyr Ala Arg Gly Thr Asp Tyr Ser Ile Leu Glu
            3870                3875                3880

 att cat cat gga agg ctg cag tac aag ttt gac tgt gga acg tgg ccc    11896
 Ile His His Gly Arg Leu Gln Tyr Lys Phe Asp Cys Gly Thr Trp Pro
        3885                3890                3895

 tgg aat tgt ctc tgt tca gag cat tca ggt caa tga tggg cagtggcacg    11946
 Trp Asn Cys Leu Cys Ser Glu His Ser Gly Gln 
    3900                3905

 cagtggccct ggaagtgaat ggaaactatg ctcgcttggt tctagaccaa gttcatactg  12006

 catcgggcac agccccaggg actctgaaaa ccctgaacct ggataactat gtgttttttg  12066

 gtggccacat ccgtcagcag ggaacaaggc atggaagaag tcctcaagtt ggtaatggtt  12126

 tcaggggttg tatggactcc atttatttga atgggcagga gctcccttta aacagcaaac  12186

 ccagaagcta tgcacacatc gaagagtcgg tggatgtatc tccaggctgc ttcctgacgg  12246

 ccacggaaga ctgcgccagc aacccttgcc agaatggagg cgtttgcaat ccgtcacctg  12306

 ctggaggtta ttactgcaaa tgcagtgcct tgtacatagg gacccactgt gagataagcg  12366

 tcaatccgtg ttcctccaac ccatgcctct atgggggcac gtgtgttgtc gacaacggag  12426

 gctttgtttg ccagtgtaga ggattatata ctggtcagag gtgtcagctt agtccatact  12486

 gcaaagatga accctgtaag aatggcggaa catgctttga cagtttggat ggcgccgttt  12546

 gtcagtgtga ttcgggtttt aggggagaaa ggtgtcagag tgatatcgac gagtgctctg  12606

 gaaacccttg cctgcacggg gccctctgtg agaacacgca cggctcctat cactgcaact  12666

 gcagccacga gtacagggga cgtcactgcg aggatgctgc gcccaaccag tatgtgtcca  12726

 cgccgtggaa cattgggttg gcggaaggaa ttggaatcgt tgtgtttgtt gcagggatat  12786

 ttttactggt ggtggtgttt gttctctgcc gtaagatgat tagtcggaaa aagaagcatc  12846

 aggctgaacc taaagacaag cacctgggac ccgctacggc tttcttgcaa agaccgtatt  12906

 ttgattccaa gctaaataag aacatttact cagacatacc accccaggtg cctgtccggc  12966

 ctatttccta caccccgagt attccaagtg actcaagaaa caatctggac cgaaattcct  13026

 tcgaaggatc tgctatccca gagcatcccg aattcagcac ttttaacccc gagtctgtgc  13086

 acgggcaccg aaaagcagtg gcggtctgca gcgtggcgcc aaacctgcct cccccacccc  13146

 cttcaaactc cccttctgac agcgactcca tccagaagcc tagctgggac tttgactatg  13206

 acacaaaagt ggtggatctt gatccctgtc tttccaagaa gcctctagag gaaaagcctt  13266

 cccagccata cagtgcccgg gaaagcctgt ctgaagtgca gtccctgagc tccttccagt  13326

 ccgaatcgtg cgatgacaat gggtatcact gggatacatc agattggatg ccaagcgttc  13386

 ctctgccgga catacaagag ttccccaact atgaggtgat tgatgagcag acacccctgt  13446

 actcagcaga tccaaacgcc atcgatacgg actattaccc tggaggctac gacatcgaaa  13506

 gtgattttcc tccaccccca gaagacttcc ccgcagctga tgagctacca ccgttaccgc  13566

 ccgaattcag caatcagttt gaatccatcc accctcctag agacatgcct gccgcgggta  13626

 gcttgggttc ttcatcaaga aaccggcaga ggttcaactt gaatcagtat ttgcccaatt  13686

 tttatcccct cgatatgtct gaacctcaaa caaaaggcac tggtgagaat agtacttgta  13746

 gagaacccca tgccccttac ccgccagggt atcaaagaca cttcgaggcg cccgctgtcg  13806

 agagcatgcc catgtctgtg tacgcctcca ccgcctcctg ctctgacgtg tcagcctgct  13866

 gcgaagtgga gtccgaggtc atgatgagtg actatgagag cggggacgac ggccacttcg  13926

 aagaggtgac gatcccgccc ctggattccc agcagcacac ggaagtctga ctctcaactc  13986

 cccccaaagt gcctgacttt agtgaaccta gaggtgatgt gagtaatccg cgctgttctt  14046

 tgcagcagtg cttccaagct ttttttggtg agccgaatgg gcatggctgc gctggatcct  14106

 gtgcctctgg acgtgctagc catttccagt gtcccaacta ctgtcatcgt gaggttttca  14166

 tcggctgtgc catttcccaa cgtcttttgg gatttacatc tgtctgtgtt aaaataatca  14226

 aacgaaaaat cagtcctgtg ttgtcagcat gattcatgta tttatataga tttgattatt  14286

 ttaattttcc tgtctctttt ttttgtaaat tttatgtaca gatttgattt ttcatagttt  14346

 taactagatt tccaagatat tttgtgcatt tgtttcaact gaattttggt ggtgtcagtg  14406

 ccattatcta gcaccctgat tttttttttt ttactataac cagggtttca ttctgtcttt  14466

 ttccactgaa gtgtgacatt ttgttagtac atttcagtgt agtcattcat ttctagctgt  14526

 acataggatg aaggagagat cagatacatg aacatgtctt acatgggttg ctgtatttag  14586

 aattataaac atttttcatt attggaaagt gtaacgggga ccttctgcat acctgtttag  14646

 aaccaaaacc accatgacac agtttttata gtgtctgtat atttgtgatg caatggtctt  14706

 gtaaaggttt ttaatgaaaa ctaccattag ccagtctttc ttactgacaa taaattatta  14766

 ataaaataaa aaaaaaaaa                                               14785




      <210> 119
      <211> 1157
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1050)

      <400> 119
 gcc  atg ggt tcc cgg gcg ctg cgg ctc tgg ctg gtc gca ccc ggt ggc      48
      Met Gly Ser Arg Ala Leu Arg Leu Trp Leu Val Ala Pro Gly Gly
        1               5                  10                  15

 ggg atc aaa tgg aga ttt ata gca aca tcg cca gct tct cag ctg tca       96
 Gly Ile Lys Trp Arg Phe Ile Ala Thr Ser Pro Ala Ser Gln Leu Ser
                  20                  25                  30

 ccg aca gaa ttg aca gaa atg cgg aat gat ctc ttt aat aaa gag aaa      144
 Pro Thr Glu Leu Thr Glu Met Arg Asn Asp Leu Phe Asn Lys Glu Lys
              35                  40                  45

 gcc agg cag tta tca tta act ccc cga act gag aag ata gaa gtt aag      192
 Ala Arg Gln Leu Ser Leu Thr Pro Arg Thr Glu Lys Ile Glu Val Lys
          50                  55                  60

 cat gtt ggg aaa act gac ccc ggt act gtc ttc gtg atg aat aaa aac      240
 His Val Gly Lys Thr Asp Pro Gly Thr Val Phe Val Met Asn Lys Asn
      65                  70                  75

 att tca act ccc tac agt tgt gcc atg cat tta agc gag tgg tat tgc      288
 Ile Ser Thr Pro Tyr Ser Cys Ala Met His Leu Ser Glu Trp Tyr Cys
  80                  85                  90                  95

 agg aag tcc att ctg gct ctg gtg gat gga cag cct tgg gac atg tat      336
 Arg Lys Ser Ile Leu Ala Leu Val Asp Gly Gln Pro Trp Asp Met Tyr
                 100                 105                 110

 aag cct tta aca aag tcc tgt gaa att aaa ttt ctt act ttc aaa gat      384
 Lys Pro Leu Thr Lys Ser Cys Glu Ile Lys Phe Leu Thr Phe Lys Asp
             115                 120                 125

 tgt gat cca gga gaa gtg aat aag gca tat tgg cgt tcc tgt gct atg      432
 Cys Asp Pro Gly Glu Val Asn Lys Ala Tyr Trp Arg Ser Cys Ala Met
         130                 135                 140

 atg atg ggc tgt gtg ata gag agg gca ttc aaa gat gaa tat atg gtc      480
 Met Met Gly Cys Val Ile Glu Arg Ala Phe Lys Asp Glu Tyr Met Val
     145                 150                 155

 aat ttg gtc aga gct cca gaa gtt cct gta att tct ggt gcc ttc tgt      528
 Asn Leu Val Arg Ala Pro Glu Val Pro Val Ile Ser Gly Ala Phe Cys
 160                 165                 170                 175

 tat gac gta gtt ttg gat agc aaa ctt gat gag tgg atg cca aca aaa      576
 Tyr Asp Val Val Leu Asp Ser Lys Leu Asp Glu Trp Met Pro Thr Lys
                 180                 185                 190

 gag aac tta cgt tcc ttc aca aag gat gct cat gct tta att tat aaa      624
 Glu Asn Leu Arg Ser Phe Thr Lys Asp Ala His Ala Leu Ile Tyr Lys
             195                 200                 205

 gat ctt cca ttt gaa act ctg gaa gtt gaa gca aaa gtg gca ttg gaa      672
 Asp Leu Pro Phe Glu Thr Leu Glu Val Glu Ala Lys Val Ala Leu Glu
         210                 215                 220

 ata ttt caa cac agc aag tac aaa gta gat ttc ata gaa gag aag gca      720
 Ile Phe Gln His Ser Lys Tyr Lys Val Asp Phe Ile Glu Glu Lys Ala
     225                 230                 235

 tct cag aac cct gag aga ata gtc aag cta cac aga ata ggt gac ttc      768
 Ser Gln Asn Pro Glu Arg Ile Val Lys Leu His Arg Ile Gly Asp Phe
 240                 245                 250                 255

 att gat gtg agt gag ggc cct ctt att cca aga aca agt att tgt ttc      816
 Ile Asp Val Ser Glu Gly Pro Leu Ile Pro Arg Thr Ser Ile Cys Phe
                 260                 265                 270

 cag tat gaa gtg tca gca gtt cac aat ctt caa ccc acc cag cca agt      864
 Gln Tyr Glu Val Ser Ala Val His Asn Leu Gln Pro Thr Gln Pro Ser
             275                 280                 285

 ctc ata cga aga ttc cag ggt gtg tct tta cct gtt cac tta aga gca      912
 Leu Ile Arg Arg Phe Gln Gly Val Ser Leu Pro Val His Leu Arg Ala
         290                 295                 300

 cat ttt aca ata tgg gat aag cta ttg gaa aga tct cgg aaa atg act      960
 His Phe Thr Ile Trp Asp Lys Leu Leu Glu Arg Ser Arg Lys Met Thr
     305                 310                 315

 cca ttt ccc att ctc ctt cta ttt act acg cag tca ttc ttc act acc     1008
 Pro Phe Pro Ile Leu Leu Leu Phe Thr Thr Gln Ser Phe Phe Thr Thr
 320                 325                 330                 335

 tcg cct gag tcg tac ctc ctc cat gga aca gtc tca gag taa ctgaaga     1057
 Ser Pro Glu Ser Tyr Leu Leu His Gly Thr Val Ser Glu 
                 340                 345

 tcaaagtaaa gcaacagagg aatgtacatc tacctaataa ctttctaaaa tttaaatatg   1117

 tataataaaa taaatgtttt aaatataaaa aaaaaaaaaa                         1157




      <210> 120
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(644)

      <400> 120
 cgctgcttag gctccgcggc ctccaagctg tagct   atg acg gcg cgc ggg act      53
                                          Met Thr Ala Arg Gly Thr
                                            1               5

 ccg agc cgc ttc ttg gcc agc gtt ctc cac aac gga ctg ggt cgc tat      101
 Pro Ser Arg Phe Leu Ala Ser Val Leu His Asn Gly Leu Gly Arg Tyr
              10                  15                  20

 gtg cag cag ctg cag cgt ctg agc ttc agc gtc agc cgc gac ggc gcc      149
 Val Gln Gln Leu Gln Arg Leu Ser Phe Ser Val Ser Arg Asp Gly Ala
          25                  30                  35

 tcg tct cgc ggc gcc agg gag ttc gtg gag cgg gag gtg atc gac ttc      197
 Ser Ser Arg Gly Ala Arg Glu Phe Val Glu Arg Glu Val Ile Asp Phe
      40                  45                  50

 gcc cga cgg aat cca ggg gtc gta ata tat gta aac tcg cgt ccg tgc      245
 Ala Arg Arg Asn Pro Gly Val Val Ile Tyr Val Asn Ser Arg Pro Cys
  55                  60                  65                  70

 tgc gtg ccc aga gta gtg gcc gaa tac ctt aac ggg gct gtg cgc gag      293
 Cys Val Pro Arg Val Val Ala Glu Tyr Leu Asn Gly Ala Val Arg Glu
                  75                  80                  85

 gag agc atc cac tgc aag tcg gtc gag gag atc tcg acg ctg gtg cag      341
 Glu Ser Ile His Cys Lys Ser Val Glu Glu Ile Ser Thr Leu Val Gln
              90                  95                 100

 aag ctg gcc gac cag tcg ggc ttg gac gtg atc cgc atc cgc aag ccc      389
 Lys Leu Ala Asp Gln Ser Gly Leu Asp Val Ile Arg Ile Arg Lys Pro
         105                 110                 115

 ttc cac acc gac aac cct agc atc cag ggc cag tgg cac ccc ttc acc      437
 Phe His Thr Asp Asn Pro Ser Ile Gln Gly Gln Trp His Pro Phe Thr
     120                 125                 130

 aac aag ccg acc acg ttc cgc ggg cta cgc ccc cga gag gtt cag gat      485
 Asn Lys Pro Thr Thr Phe Arg Gly Leu Arg Pro Arg Glu Val Gln Asp
 135                 140                 145                 150

 cct gcc cca gcc cag gac act ggc ctg aga ctg tct gca gtt gca ccg      533
 Pro Ala Pro Ala Gln Asp Thr Gly Leu Arg Leu Ser Ala Val Ala Pro
                 155                 160                 165

 cag atc ctc ctg ccc ggc tgg ccc gac cca ata tca gtt cag tca tcc      581
 Gln Ile Leu Leu Pro Gly Trp Pro Asp Pro Ile Ser Val Gln Ser Ser
             170                 175                 180

 gat ctt cct tgg gga aat acc cat tac cgt cct gaa ccc ttg tca tcc      629
 Asp Leu Pro Trp Gly Asn Thr His Tyr Arg Pro Glu Pro Leu Ser Ser
         185                 190                 195

 act act tgg cta taa gctccagaag tgacaagaca cttcacatct taaatatgtt      684
 Thr Thr Trp Leu 
     200

 tcctagttta taattcattt gggcagtaaa tgtttgttga gcaaaaaaaa aaaaaaaaaa    744




      <210> 121
      <211> 1582
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(633)

      <400> 121
 ctgaaccccg cctgctggac cgcttcggaa ttcccgggtc gacccacgcg tccgcccccg     60

 cccagg   atg gcg gaa gtg gag gcg ccg acg gcg gcc gag acg gac atg     108
          Met Ala Glu Val Glu Ala Pro Thr Ala Ala Glu Thr Asp Met
            1               5                  10

 aag caa tat caa ggc tcc ggc ggc gtc gcc atg gat gtg gaa cgg agt      156
 Lys Gln Tyr Gln Gly Ser Gly Gly Val Ala Met Asp Val Glu Arg Ser
  15                  20                  25                  30

 cgc ttc ccc tac tgc gtg gtg tgg acg ccc atc ccg gtg ctc acg tgg      204
 Arg Phe Pro Tyr Cys Val Val Trp Thr Pro Ile Pro Val Leu Thr Trp
                  35                  40                  45

 ttt ttc ccc atc atc ggc cac atg ggc atc tgc aca tcc aca gga gtc      252
 Phe Phe Pro Ile Ile Gly His Met Gly Ile Cys Thr Ser Thr Gly Val
              50                  55                  60

 att cgg gac ttc gcg ggc ccc tac ttt gtc tca gag gac aac atg gcc      300
 Ile Arg Asp Phe Ala Gly Pro Tyr Phe Val Ser Glu Asp Asn Met Ala
          65                  70                  75

 ttt gga aag cct gcc aag tac tgg aag ttg gac cct gct cag gtc tat      348
 Phe Gly Lys Pro Ala Lys Tyr Trp Lys Leu Asp Pro Ala Gln Val Tyr
      80                  85                  90

 gct agc ggg ccc aac gca tgg gac acg gct gtg cac gac gcc tct gag      396
 Ala Ser Gly Pro Asn Ala Trp Asp Thr Ala Val His Asp Ala Ser Glu
  95                 100                 105                 110

 gag tac aag cac cgc atg cac aat ctc tgc tgt gac aac tgc cac tcg      444
 Glu Tyr Lys His Arg Met His Asn Leu Cys Cys Asp Asn Cys His Ser
                 115                 120                 125

 cac gtg gca ttg gcc ctg aat ctg atg cgc tac aac aac agc acc aac      492
 His Val Ala Leu Ala Leu Asn Leu Met Arg Tyr Asn Asn Ser Thr Asn
             130                 135                 140

 tgg aat atg gtg acg ctc tgc ttc ttc tgc ctg ctc tac ggg aag tac      540
 Trp Asn Met Val Thr Leu Cys Phe Phe Cys Leu Leu Tyr Gly Lys Tyr
         145                 150                 155

 gtc agc gtt ggg gcc ttc gtg aag acc tgg ctg ccc ttc atc ctt ctc      588
 Val Ser Val Gly Ala Phe Val Lys Thr Trp Leu Pro Phe Ile Leu Leu
     160                 165                 170

 ctg ggc atc atc ctc acc gtc agc ctg gtc ttt aac ctc cgg tga tgg      636
 Leu Gly Ile Ile Leu Thr Val Ser Leu Val Phe Asn Leu Arg 
 175                 180                 185

 ctgctcggtg gccccacacc caccagggtc ccgaggaaac agccgccatc ccttttggtt    696

 ccagattttt ttctcctcac cccaaaaggc agggttgggc ctgctgttgt ggaccggggg    756

 tcggggctgg caggatggaa ggactgagga ccagcatgaa gtgggggttt gttgtctccc    816

 tgcctctcag aagcaccctg tcccctcctc cccaggcctg tgactccggc cctggaagcc    876

 cctttgttct tctgttgaaa ggctttggct tccctctgta gagctgctcc cgccaccacc    936

 tgctggggtc ctgcctcagc ccagtgccca gtatggggag aggaggacat ttgggctcac    996

 ctgtcaaggt ggccctggga ccagagctgg tcccagcatg gggtgcaccg ggtacactta   1056

 acgtgtctct ataagccaag ttgcttcagg accttcacca ctggcctcta gaatggtcca   1116

 gaggggctgg ctgggtccct ttgtcagact cctgccggca gctgccctgg gggacatgtg   1176

 tgcccatctg gcatcctcca gcccgtgcag tccgctcttc actgttccac ggcctcccag   1236

 tgcctcccag cattggaccc atctccccct gcagtttgag gccagagagg tgagtggacc   1296

 tgacaagtgc cagagtaacc gtgtagacag agcagtgtag acagcgctca gccccagccc   1356

 caggtgtgga cctcatgctg gtgatggctc ccctgggtgg cctgccagca cagccagtgc   1416

 catcagggag ctgaaggggc tgtcccccac ctaactccag ctcccccttc acgttgtcac   1476

 caaggccctg tgccgcccgc ctcgcccccc tgctctgtgg attcctttgg gaagggctcc   1536

 ctgggcagga caataaagag ttttgactcc aaaaaaaaaa aaaaaa                  1582




      <210> 122
      <211> 834
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(550)

      <400> 122
 tttcgtctcc   atg gcc cgg gga ggc gtg agt gcc agg gtt ctg ctg cag      49
              Met Ala Arg Gly Gly Val Ser Ala Arg Val Leu Leu Gln
                1               5                  10

 gct gcc agg ggc acc tgg tgg aac aga cct ggg ggc act tcc ggg tcg       97
 Ala Ala Arg Gly Thr Trp Trp Asn Arg Pro Gly Gly Thr Ser Gly Ser
      15                  20                  25

 ggg gag ggg gtg gcg ctg ggg aca acc aga aag ttt caa gcg aca ggc      145
 Gly Glu Gly Val Ala Leu Gly Thr Thr Arg Lys Phe Gln Ala Thr Gly
  30                  35                  40                  45

 tcg cgc ccg gcg gga gag gag gac gcg ggc ggc ccg gag cgg ccc ggg      193
 Ser Arg Pro Ala Gly Glu Glu Asp Ala Gly Gly Pro Glu Arg Pro Gly
                  50                  55                  60

 gac gtg gtg aac gtg gtg ttc gta gac cgc tca ggc cag cgg atc cca      241
 Asp Val Val Asn Val Val Phe Val Asp Arg Ser Gly Gln Arg Ile Pro
              65                  70                  75

 gtg agt ggc aga gtc ggg gac aat gtt ctt cac ctg gcc cag cgc cac      289
 Val Ser Gly Arg Val Gly Asp Asn Val Leu His Leu Ala Gln Arg His
          80                  85                  90

 ggg gtg gac ctg gaa ggg gcc tgt gaa gcc tcc ctg gcc tgc tcc acc      337
 Gly Val Asp Leu Glu Gly Ala Cys Glu Ala Ser Leu Ala Cys Ser Thr
      95                 100                 105

 tgc cat gtg tat gtg agt gaa gac cac ctg gat ctc ctg cct cct ccc      385
 Cys His Val Tyr Val Ser Glu Asp His Leu Asp Leu Leu Pro Pro Pro
 110                 115                 120                 125

 gag gag agg gaa gac gac atg cta gac atg gcc ccc ctc ctc cag gag      433
 Glu Glu Arg Glu Asp Asp Met Leu Asp Met Ala Pro Leu Leu Gln Glu
                 130                 135                 140

 aac tcg cgg ctg ggc tgc cag att gtg ctg aca ccg gag ctg gaa gga      481
 Asn Ser Arg Leu Gly Cys Gln Ile Val Leu Thr Pro Glu Leu Glu Gly
             145                 150                 155

 gcg gaa ttc acc ctg ccc aag atc acc agg aac ttc tac gtg gat ggc      529
 Ala Glu Phe Thr Leu Pro Lys Ile Thr Arg Asn Phe Tyr Val Asp Gly
         160                 165                 170

 cat gtc ccc aag ccc cac tga ca tgaacacctg gaccattcca cattgccatg      582
 His Val Pro Lys Pro His 
     175

 gccccagggc ccagattgag ggaatagcca ggtgccagcc ctgcccagag tgcggacagg    642

 cccgggagag acgtggaagc ccctgtgaag gacaacaccc ctgcttggga gagagtccca    702

 tgtccaggct ctggtgggga cagggcccct agtggggtgg ccttccccag gcccctgaga    762

 atcagggttt gagtaggagt ggactcatat tggagctgca ataaatcgat aacacaggaa    822

 aaaaaaaaaa aa                                                        834




      <210> 123
      <211> 2000
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(801)

      <400> 123
 aaggatcctt aattaaatta atcccccccc ccccccccgg ggcgctggcg gcggcggagg     60

 agagggagca gcgtcacggg cgcccggccc gttaaaacgc tgctggctgg agccacctcc    120

 ctccctgcag cccgcaacgg gaatggagta aagggagacc cgtcgacctg gccacgggga    180

 tcagcg   atg gaa tta aag caa tct ttg tcc acc cat ctg gaa gcc gag     228
          Met Glu Leu Lys Gln Ser Leu Ser Thr His Leu Glu Ala Glu
            1               5                  10

 aag cct ctg agg cgc tat ggg gcg gtg gag gag acg gct tgg aaa acg      276
 Lys Pro Leu Arg Arg Tyr Gly Ala Val Glu Glu Thr Ala Trp Lys Thr
  15                  20                  25                  30

 gag aga ctg ggg aga aat cag ctg gac atc atc tcc atg gcg gag aca      324
 Glu Arg Leu Gly Arg Asn Gln Leu Asp Ile Ile Ser Met Ala Glu Thr
                  35                  40                  45

 acc atg atg cca gag gag att gag ctg gag atg gca aaa att cag cgt      372
 Thr Met Met Pro Glu Glu Ile Glu Leu Glu Met Ala Lys Ile Gln Arg
              50                  55                  60

 ctc cgg gaa gtc ttg gtc cgc cgg gag tct gag ctc agg ttc atg atg      420
 Leu Arg Glu Val Leu Val Arg Arg Glu Ser Glu Leu Arg Phe Met Met
          65                  70                  75

 gat gac atc cag ctc tgc aag gac atc atg gac ttg aag cag gag ctg      468
 Asp Asp Ile Gln Leu Cys Lys Asp Ile Met Asp Leu Lys Gln Glu Leu
      80                  85                  90

 cag aac ttg gtc gcc atc cca gaa aaa gaa aaa acc aaa ctg cag aag      516
 Gln Asn Leu Val Ala Ile Pro Glu Lys Glu Lys Thr Lys Leu Gln Lys
  95                 100                 105                 110

 cag aga gag gat gag cta atc cag aag atc cac aaa ctg gtg cag aag      564
 Gln Arg Glu Asp Glu Leu Ile Gln Lys Ile His Lys Leu Val Gln Lys
                 115                 120                 125

 aga gac ttc ctg gtg gac gat gcg gag gtc gag cgg tta agg gag caa      612
 Arg Asp Phe Leu Val Asp Asp Ala Glu Val Glu Arg Leu Arg Glu Gln
             130                 135                 140

 gaa gaa gac aag gaa atg gct gat ttc ctg aga atc aag tta aaa cct      660
 Glu Glu Asp Lys Glu Met Ala Asp Phe Leu Arg Ile Lys Leu Lys Pro
         145                 150                 155

 cta gac aaa gta acc aaa tct cca gcc agc tcc cgg gca gag aag aaa      708
 Leu Asp Lys Val Thr Lys Ser Pro Ala Ser Ser Arg Ala Glu Lys Lys
     160                 165                 170

 gca gag ccc cca cct agc aag ccc acg gtg gcc aag acg ggg ctg gca      756
 Ala Glu Pro Pro Pro Ser Lys Pro Thr Val Ala Lys Thr Gly Leu Ala
 175                 180                 185                 190

 ctg atc aag gat tgt tgc ggg gcc acc cag tgc aac atc atg tag ccc      804
 Leu Ile Lys Asp Cys Cys Gly Ala Thr Gln Cys Asn Ile Met 
                 195                 200

 ccacgtgggg tgccctgggc catggggacc cccccccacc ctcttgtctt tatagccccc    864

 atttcaccgg ggcccaagag ctctccaagg cagaaggggt tgaaggcaag cccgtgactg    924

 tcaccagagg ccatgggcac ggcaggcggg cctggccacc ctgtacagag tgtagcagta    984

 gggagtctct caccgtcgca tggtcctccc cagagcatgc cgaacccagg agtctgtctc   1044

 actgtttatc caaacaccag gaaaggtcct ccctcaaaaa agcatatctc cacttctctc   1104

 tagctgtatc taacccaccg tgtgaatgaa ctgggagagg ggcatgctcc ccagctgtgt   1164

 gtagtcgtga cttctcaaca atctagcacc atgtcggaca cgttccccat ccaccctcct   1224

 agctctgctc tcagagctag gcacatgggc acaggtcccc tcccgtctgt cctctcccag   1284

 caactgtgcc ctggagggct ccacatggcc cccgtgtctc tcgggcacca cccatatagc   1344

 agtcccagag ggcccatctg taaagatcga gcttgtgtgt ggtgtcgtgg tcacatctcc   1404

 cgcttccccc catcctgtgt ctgggcacag ttcacatcag gacagcgtcc attgtgctct   1464

 cagtctgcct caggtgtgtg cctggagggg gcctggactg gcatggatcc agtgtgcaga   1524

 agagccagca gggaaccgga agctctgatg tcaaggccag agcagttgag aatgggaccc   1584

 agagtagatg ctgacctggg cactccacca ttccggggcc accacagaga tgccagcagg   1644

 atgccacttt gccagcccga cacacggacc tttgtaaaga acagcaacag gcaggagagg   1704

 cagcgtgtga ccagattgtg tcccgtcatt gggtggcata tgttaactag ctgccaaaca   1764

 acttcaaccc gtgtaattca tgtacatttg caacagccag cccggtacag cctgtgtgac   1824

 ttctctgtat gtgtgtgtgt gtcgtgacca gcctaagtag ttagcataac tcaagatgct   1884

 gatgtgcagt cacccatcag agaaaataaa aatggaaacc acgttcacag cattttaaaa   1944

 gtttttactt tttttcttga ttatggaagt aatccatgta catagtaaat catttt       2000




      <210> 124
      <211> 2335
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(1604)

      <400> 124
 tggaatctgt ggtgcaagtg tctggtacag tcatttcccg tcctgcagga caagagaatc     60

 caaaa    atg cca aca ggt gag att gaa atc aaa gtt aaa aca gct gag     107
          Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys Thr Ala Glu
            1               5                  10

 ctt ctg aat gcc tgc aag aag ctg ccc ttt gaa att aag aac ttc gtg      155
 Leu Leu Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys Asn Phe Val
  15                  20                  25                  30

 aag aaa aca gag gct ctt cgg ttg cag tat cgc tac tta gac ttg cgt      203
 Lys Lys Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu Asp Leu Arg
                  35                  40                  45

 agt ttc caa atg cag tat aac ctg cga ctg agg tcc cag atg gtc atg      251
 Ser Phe Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln Met Val Met
              50                  55                  60

 aaa atg cgg gaa tat ctc tgt aat ctg cat ggg ttt gtg gat ata gaa      299
 Lys Met Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val Asp Ile Glu
          65                  70                  75

 acc ccc aca ttg ttt aag agg acc cca ggg ggt gcc aaa gag ttt tta      347
 Thr Pro Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys Glu Phe Leu
      80                  85                  90

 gta cca tcc agg gaa cct gga aag ttt tat tct ctc cct cag agt cct      395
 Val Pro Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro Gln Ser Pro
  95                 100                 105                 110

 caa cag ttt aag caa ctt ctg atg gtt ggc ggt tta gac aga tat ttt      443
 Gln Gln Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp Arg Tyr Phe
                 115                 120                 125

 cag gtt gcc cga tgt tat cga gat gaa ggt tca aga cca gac aga cag      491
 Gln Val Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro Asp Arg Gln
             130                 135                 140

 cct gag ttt act cag att gac ata gag atg tca ttt gta gac cag act      539
 Pro Glu Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val Asp Gln Thr
         145                 150                 155

 ggg atc cag agt tta att gag ggt ttg ctc cag tat tcc tgg ccc aat      587
 Gly Ile Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser Trp Pro Asn
     160                 165                 170

 gac aaa gat cct gtg gtt gtt cct ttt cct act atg act ttt gct gag      635
 Asp Lys Asp Pro Val Val Val Pro Phe Pro Thr Met Thr Phe Ala Glu
 175                 180                 185                 190

 gtg ctg gcc acc tat gga act gat aaa cct gac act cgc ttt gga atg      683
 Val Leu Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg Phe Gly Met
                 195                 200                 205

 aag att ata gat atc agt gat gtg ttt aga aac aca gag att gga ttt      731
 Lys Ile Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu Ile Gly Phe
             210                 215                 220

 ctt caa gat gca ctt agt aag ccc cat gga act gtg aaa gcc ata tgt      779
 Leu Gln Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys Ala Ile Cys
         225                 230                 235

 atc cct gaa gga gca aaa tac tta aaa agg aaa gac att gaa tcc att      827
 Ile Pro Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile Glu Ser Ile
     240                 245                 250

 aga aac ttt gca gct gac cat ttt aat cag gaa atc tta cct gta ttc      875
 Arg Asn Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu Pro Val Phe
 255                 260                 265                 270

 ctt aac gcc aat aga aac tgg aat tct cca gtt gct aat ttc ata atg      923
 Leu Asn Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn Phe Ile Met
                 275                 280                 285

 gag tca caa aga ctg gaa tta atc aga cta atg gag acc caa gag gaa      971
 Glu Ser Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr Gln Glu Glu
             290                 295                 300

 gat gtg gtc cta cta act gct gga gag cac aat aaa gca tgc tct ttg     1019
 Asp Val Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala Cys Ser Leu
         305                 310                 315

 tta gga aaa tta cga ctg gaa tgt gct gac ctt cta aaa aca aga gga     1067
 Leu Gly Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Lys Thr Arg Gly
     320                 325                 330

 gtg gtg ctc cgt gac ccc act ctg ttc tct ttc ctt tgg gtg gta gat     1115
 Val Val Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp Val Val Asp
 335                 340                 345                 350

 ttc cca ctc ttc ctg ccc aag gag gaa agt ccc aga gag ctg gaa tcg     1163
 Phe Pro Leu Phe Leu Pro Lys Glu Glu Ser Pro Arg Glu Leu Glu Ser
                 355                 360                 365

 gcc cac cac cca ttt act gct ccc cac ccc agt gac ata cat ctc ctg     1211
 Ala His His Pro Phe Thr Ala Pro His Pro Ser Asp Ile His Leu Leu
             370                 375                 380

 tac act gag ccc aaa aag gcc cgt agc caa cac tat gac ttg gtt tta     1259
 Tyr Thr Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp Leu Val Leu
         385                 390                 395

 aat ggc aat gaa ata gga ggt ggt tca att cga att cac aat gca gag     1307
 Asn Gly Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His Asn Ala Glu
     400                 405                 410

 ctg cag cgt tat atc ctg gca acc tta cta aag gag gat gtg aaa atg     1355
 Leu Gln Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp Val Lys Met
 415                 420                 425                 430

 ctc tcc cat ctg ctc cag gct tta gat tat ggg gca ccc cct cat gga     1403
 Leu Ser His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro Pro His Gly
                 435                 440                 445

 gga att gcc tta ggg tta gac aga ctg ata tgc ctt gtc act gga tct     1451
 Gly Ile Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val Thr Gly Ser
             450                 455                 460

 cca agc atc aga gat gtc ata gcc ttc cca aag tcc ttc cgg gga cat     1499
 Pro Ser Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe Arg Gly His
         465                 470                 475

 gac ctc atg agc aat acc cca gat tct gtc cct cct gag gaa ctg aag     1547
 Asp Leu Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu Glu Leu Lys
     480                 485                 490

 ccc tat cat atc cga gtc tcc aag cca aca gac tcc aaa gca gaa aga     1595
 Pro Tyr His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys Ala Glu Arg
 495                 500                 505                 510

 gct cat tga atcatgc ataccatgca gaaagttgag cttttaggtt ttgtcctctt     1651
 Ala His 


 tgcttcccca aggctaaagt cagatctaga gttctgccac aggtctaaca atcaagtctt   1711

 tagatggaag gaatccaggc aacattcttc accacaacga agaaacagat aaaagatacc   1771

 caattttgac ttgatttcat gcatcatttg gatttttttt ggttaggact ttttttgaag   1831

 ttccttttta cttaggtgtg aaagatggtt ctttgttgaa ataatatagt ggtttagtgt   1891

 tttcaaatca tgtttctcat acccagatag tagattattc acttaggaca gaggtaatca   1951

 aattatgtgt gaaatgtagg aaaatgcttg cccctgtaaa ctagtgagtt gatggagcat   2011

 ttgcttcatc atcctcatca agagaatcat ataaattaag ctttataatg acatttcaac   2071

 catcaacata atatagtgag gagtagcata atatttttta ataatgcaga aaacatcact   2131

 gaaatgagag tcacaaattt ttcttcagtg tttcagcctg agtaagttac ataaacctcg   2191

 cttagcctcc cttcctgcta atgtgtaaaa tacatacttg ccctggctac ctcaccgggc   2251

 tgttattgct ggaatcagag gagataacat atatggaaga taaagtgaat aaaagtactt   2311

 tgaaaaacta aaaaaaaaaa aaaa                                          2335




      <210> 125
      <211> 4101
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(2297)

      <400> 125
 gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aag   atg      56
                                                              Met
                                                                1

 gcg gac gag gcg gcc ctc gcc ctt cag ccc ggc ggc tcc ccc tcg gcg      104
 Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser Ala
               5                  10                  15

 gcg ggg gcc gac agg gag gcc gcg tcg tcc ccc gcc ggg gag ccg ctc      152
 Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro Leu
          20                  25                  30

 cgc aag agg ccg cgg aga gat ggt ccc ggc ctc gag cgg agc ccg ggc      200
 Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro Gly
      35                  40                  45

 gag ccc ggt ggg gcg gcc cca gag cgt gag gtg ccg gcg gcg gcc agg      248
 Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala Arg
  50                  55                  60                  65

 ggc tgc ccg ggt gcg gcg gcg gcg gcg ctg tgg cgg gag gcg gag gca      296
 Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu Ala
                  70                  75                  80

 gag gcg gcg gcg gca ggc ggg gag caa gag gcc cag gcg act gcg gcg      344
 Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala Ala
              85                  90                  95

 gct ggg gaa gga gac aat ggg ccg ggc ctg cag ggc cca tct cgg gag      392
 Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg Glu
         100                 105                 110

 cca ccg ctg gcc gac aac ttg tac gac gaa gac gac gac gac gag ggc      440
 Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu Gly
     115                 120                 125

 gag gag gag gaa gag gcg gcg gcg gcg gcg att ggg tac cga gat aac      488
 Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp Asn
 130                 135                 140                 145

 ctt ctg ttc ggt gat gaa att atc act aat ggt ttt cat tcc tgt gaa      536
 Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys Glu
                 150                 155                 160

 agt gat gag gag gat aga gcc tca cat gca agc tct agt gac tgg act      584
 Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp Thr
             165                 170                 175

 cca agg cca cgg ata ggt cca tat act ttt gtt cag caa cat ctt atg      632
 Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met
         180                 185                 190

 att ggc aca gat cct cga aca att ctt aaa gat tta ttg ccg gaa aca      680
 Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr
     195                 200                 205

 ata cct cca cct gag ttg gat gat atg aca ctg tgg cag att gtt att      728
 Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile
 210                 215                 220                 225

 aat atc ctt tca gaa cca cca aaa agg aaa aaa aga aaa gat att aat      776
 Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn
                 230                 235                 240

 aca att gaa gat gct gtg aaa tta ctg caa gag tgc aaa aaa att ata      824
 Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile
             245                 250                 255

 gtt cta act gga gct ggg gtg tct gtt tca tgt gga ata cct gac ttc      872
 Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe
         260                 265                 270

 agg tca agg gat ggt att tat gct cgc ctt gct gta gac ttc cca gat      920
 Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp
     275                 280                 285

 ctt cca gat cct caa gcg atg ttt gat att gaa tat ttc aga aaa gat      968
 Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp
 290                 295                 300                 305

 cca aga cca ttc ttc aag ttt gca aag gaa ata tat cct gga caa ttc     1016
 Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe
                 310                 315                 320

 cag cca tct ctc tgt cac aaa ttc ata gcc ttg tca gat aag gaa gga     1064
 Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly
             325                 330                 335

 aaa cta ctt cgc aac tat acc cag aac ata gac acg ctg gaa cag gtt     1112
 Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val
         340                 345                 350

 gcg gga atc caa agg ata att cag tgt cat ggt tcc ttt gca aca gca     1160
 Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala
     355                 360                 365

 tct tgc ctg att tgt aaa tac aaa gtt gac tgt gaa gct gta cga gga     1208
 Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly
 370                 375                 380                 385

 gat att ttt aat cag gta gtt cct cga tgt cct agg tgc cca gct gat     1256
 Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp
                 390                 395                 400

 gaa ccg ctt gct atc atg aaa cca gag att gtg ttt ttt ggt gaa aat     1304
 Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn
             405                 410                 415

 tta cca gaa cag ttt cat aga gcc atg aag tat gac aaa gat gaa gtt     1352
 Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val
         420                 425                 430

 gac ctc ctc att gtt att ggg tct tcc ctc aaa gta aga cca gta gca     1400
 Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala
     435                 440                 445

 cta att cca agt tcc ata ccc cat gaa gtg cct cag ata tta att aat     1448
 Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn
 450                 455                 460                 465

 aga gaa cct ttg cct cat ctg cat ttt gat gta gag ctt ctt gga gac     1496
 Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly Asp
                 470                 475                 480

 tgt gat gtc ata att aat gaa ttg tgt cat agg tta ggt ggt gaa tat     1544
 Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr
             485                 490                 495

 gcc aaa ctt tgc tgt aac cct gta aag ctt tca gaa att act gaa aaa     1592
 Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys
         500                 505                 510

 cct cca cga aca caa aaa gaa ttg gct tat ttg tca gag ttg cca ccc     1640
 Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro Pro
     515                 520                 525

 aca cct ctt cat gtt tca gaa gac tca agt tca cca gaa aga act tca     1688
 Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr Ser
 530                 535                 540                 545

 cca cca gat tct tca gtg att gtc aca ctt tta gac caa gca gct aag     1736
 Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala Lys
                 550                 555                 560

 agt aat gat gat tta gat gtg tct gaa tca aaa ggt tgt atg gaa gaa     1784
 Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu Glu
             565                 570                 575

 aaa cca cag gaa gta caa act tct agg aat gtt gaa agt att gct gaa     1832
 Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala Glu
         580                 585                 590

 cag atg gaa aat ccg gat ttg aag aat gtt ggt tct agt act ggg gag     1880
 Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly Glu
     595                 600                 605

 aaa aat gaa aga act tca gtg gct gga aca gtg aga aaa tgc tgg cct     1928
 Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp Pro
 610                 615                 620                 625

 aat aga gtg gca aag gag cag att agt agg cgg ctt gat ggt aat cag     1976
 Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn Gln
                 630                 635                 640

 tat ctg ttt ttg cca cca aat cgt tac att ttc cat ggc gct gag gta     2024
 Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu Val
             645                 650                 655

 tat tca gac tct gaa gat gac gtc tta tcc tct agt tct tgt ggc agt     2072
 Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly Ser
         660                 665                 670

 aac agt gat agt ggg aca tgc cag agt cca agt tta gaa gaa ccc atg     2120
 Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro Met
     675                 680                 685

 gag gat gaa agt gaa att gaa gaa ttc tac aat ggc tta gaa gat gag     2168
 Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp Glu
 690                 695                 700                 705

 cct gat gtt cca gag aga gct gga gga gct gga ttt ggg act gat gga     2216
 Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp Gly
                 710                 715                 720

 gat gat caa gag gca att aat gaa gct ata tct gtg aaa cag gaa gta     2264
 Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu Val
             725                 730                 735

 aca gac atg aac tat cca tca aac aaa tca tag tgtaataa ttgtgcaggt     2315
 Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
         740                 745

 acaggaattg ttccaccagc attaggaact ttagcatgtc aaaatgaatg tttacttgtg   2375

 aactcgatag agcaaggaaa ccagaaaggt gtaatattta taggttggta aaatagattg   2435

 tttttcatgg ataattttta acttcattat ttctgtactt gtacaaactc aacactaact   2495

 tttttttttt taaaaaaaaa aaggtactaa gtatcttcaa tcagctgttg gtcaagacta   2555

 actttctttt aaaggttcat ttgtatgata aattcatatg tgtatatata attttttttg   2615

 ttttgtctag tgagtttcaa catttttaaa gttttcaaaa agccatcgga atgttaaatt   2675

 aatgtaaagg gaacagctaa tctagaccaa agaatggtat tttcactttt ctttgtaaca   2735

 ttgaatggtt tgaagtactc aaaatctgtt acgctaaact tttgattctt taacacaatt   2795

 atttttaaac actggcattt tccaaaactg tggcagctaa ctttttaaaa tctcaaatga   2855

 catgcagtgt gagtagaagg aagtcaacaa tatgtgggga gagcactcgg ttgtctttac   2915

 ttttaaaagt aatacttggt gctaagaatt tcaggattat tgtatttacg ttcaaatgaa   2975

 gatggctttt gtacttcctg tggacatgta gtaatgtcta tattggctca taaaactaac   3035

 ctgaaaaaca aataaatgct ttggaaatgt ttcagttgct ttagaaacat tagtgcctgc   3095

 ctggatcccc ttagttttga aatatttgcc attgttgttt aaatacctat cactgtggta   3155

 gagcttgcat tgatcttttc cacaagtatt aaactgccaa aatgtgaata tgcaaagcct   3215

 ttctgaatct ataataatgg tacttctact ggggagagtg taatattttg gactgctgtt   3275

 ttccattaat gaggagagca acaggcccct gattatacag ttccaaagta ataagatgtt   3335

 aattgtaatt cagccagaaa gtacatgtct cccattggga ggatttggtg ttaaatacca   3395

 aactgctagc cctagtatta tggagatgaa catgatgatg taacttgtaa tagcagaata   3455

 gttaatgaat gaaactagtt cttataattt atctttattt aaaagcttag cctgccttaa   3515

 aactagagat caactttctc agctgcaaaa gcttctagtc tttcaagaag ttcatacttt   3575

 atgaaattgc acagtaagca tttatttttc agaccatttt tgaacatcac tcctaaatta   3635

 ataaagtatt cctctgttgc tttagtattt attacaataa aaagggtttg aaatatagct   3695

 gttctttatg cataaaacac ccagctagga ccattactgc cagagaaaaa aatcgtattg   3755

 aatggccatt tccctactta taagatgtct caatctgaat ttatttggct acactaaaga   3815

 atgcagtata tttagttttc catttgcatg atgtttgtgt gctatagatg atattttaaa   3875

 ttgaaaagtt tgttttaaat tatttttaca gtgaagactg ttttcagctc tttttatatt   3935

 gtacatagtc ttttatgtaa tttactggca tatgttttgt agactgttta atgactggat   3995

 atcttccttc aacttttgaa atacaaaacc agtgtttttt acttgtacac tgttttaaag   4055

 tctattaaaa ttgtcatttg acttttttct gttaaaaaaa aaaaaa                  4101




      <210> 126
      <211> 563
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(509)

      <400> 126
 gcacgagcgc aggctcagtt atgggttcct gtgtgcttag tcatcgggtc cgacacaggc     60

 tggactgatc tggggagccg cgaagggcct gccttcacaa agggacgtaa cgcaagtact    120

 gcgggcagtg tttgaat   atg gcc ctg aac aat gtg tcc ctg tcc tcc ggt     170
                      Met Ala Leu Asn Asn Val Ser Leu Ser Ser Gly
                        1               5                  10

 gat cag agg agc agg gtg gcc tac cgc tct tcc cat ggc gac ctc aga      218
 Asp Gln Arg Ser Arg Val Ala Tyr Arg Ser Ser His Gly Asp Leu Arg
              15                  20                  25

 ccg cgg gcg tca gcg ttg gcg atg gtc tcc gga gac ggc ttc ctc gtt      266
 Pro Arg Ala Ser Ala Leu Ala Met Val Ser Gly Asp Gly Phe Leu Val
          30                  35                  40

 tcc agg cct gaa gcg att cat cta gga cct cgg cag gcg gtg cga cca      314
 Ser Arg Pro Glu Ala Ile His Leu Gly Pro Arg Gln Ala Val Arg Pro
      45                  50                  55

 agc gtt cgg gcc gag agc cgt cga gtg gat ggt ggc ggc cgg agc cca      362
 Ser Val Arg Ala Glu Ser Arg Arg Val Asp Gly Gly Gly Arg Ser Pro
  60                  65                  70                  75

 agg gaa cca gat ggc cgg ggc cgg agc cgc caa gcc aga ttc tca cct      410
 Arg Glu Pro Asp Gly Arg Gly Arg Ser Arg Gln Ala Arg Phe Ser Pro
                  80                  85                  90

 tac cca atc cct gcc gtt gaa ccc gat ctc cta aga agt gtg ctg caa      458
 Tyr Pro Ile Pro Ala Val Glu Pro Asp Leu Leu Arg Ser Val Leu Gln
              95                 100                 105

 cag cgt ttg att gca tta gga ggt gtt atc gca gct cga att tca gtt      506
 Gln Arg Leu Ile Ala Leu Gly Gly Val Ile Ala Ala Arg Ile Ser Val
         110                 115                 120

 taa acga acacctttcc tctggccctc acttagcttg tgaacaggcc tttttaaaat      563
 






      <210> 127
      <211> 1721
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(1551)

      <400> 127
 cacgagttcc tgcatgaggt tccagcggcc agcgaggaaa tcttcaaaat tgcctca        57                                                                 
 atg gcc ccc ggg gcg ctg ctc ctg gag gct cag aag gag tat gag aaa      105
 Met Ala Pro Gly Ala Leu Leu Leu Glu Ala Gln Lys Glu Tyr Glu Lys
   1               5                  10                  15

 gag agc cag aag gcg gac gag tac ctg cgg gag atc cag gag ctg ggc      153
 Glu Ser Gln Lys Ala Asp Glu Tyr Leu Arg Glu Ile Gln Glu Leu Gly
              20                  25                  30

 cag ctg acc cag gcc gtg cag cag tgc att gag gct gca gga cat gag      201
 Gln Leu Thr Gln Ala Val Gln Gln Cys Ile Glu Ala Ala Gly His Glu
          35                  40                  45

 cac cag cca gac atg cag aag agt ctg ctc agg gcc gcc tcc ttc gga      249
 His Gln Pro Asp Met Gln Lys Ser Leu Leu Arg Ala Ala Ser Phe Gly
      50                  55                  60

 aag tgt ttc ctg gac aga ttt cca ccc gac agc ttc gtg cac atg tgt      297
 Lys Cys Phe Leu Asp Arg Phe Pro Pro Asp Ser Phe Val His Met Cys
  65                  70                  75                  80

 cag gac ctg cgt gtg ctc aat gct gtt cgg gac tat cac atc ggg atc      345
 Gln Asp Leu Arg Val Leu Asn Ala Val Arg Asp Tyr His Ile Gly Ile
                  85                  90                  95

 ccg ctc acc tat agc caa tat aag cag ctc acc atc cag gtg ctg ctg      393
 Pro Leu Thr Tyr Ser Gln Tyr Lys Gln Leu Thr Ile Gln Val Leu Leu
             100                 105                 110

 gac agg ctc gtg ttg cgg aga ctt tac ccc ctg gcc atc cag ata tgc      441
 Asp Arg Leu Val Leu Arg Arg Leu Tyr Pro Leu Ala Ile Gln Ile Cys
         115                 120                 125

 gag tac ttg cgc ctt cct gaa gta cag ggc gtc agc agg atc ctg gcc      489
 Glu Tyr Leu Arg Leu Pro Glu Val Gln Gly Val Ser Arg Ile Leu Ala
     130                 135                 140

 cac tgg gcc tgc tac aag gtg caa cag aag gat gtc tca gat gag gat      537
 His Trp Ala Cys Tyr Lys Val Gln Gln Lys Asp Val Ser Asp Glu Asp
 145                 150                 155                 160

 gtg gct cga gcc att aac cag aag ctg ggg gac acg cct ggt gtc tct      585
 Val Ala Arg Ala Ile Asn Gln Lys Leu Gly Asp Thr Pro Gly Val Ser
                 165                 170                 175

 tac tcc gac att gct gca cga gcc tat ggt tgt ggc cgc acg gag ctg      633
 Tyr Ser Asp Ile Ala Ala Arg Ala Tyr Gly Cys Gly Arg Thr Glu Leu
             180                 185                 190

 gcc atc aag ctg ctg gag tat gag cca cgc tca ggg gag cag gta ccc      681
 Ala Ile Lys Leu Leu Glu Tyr Glu Pro Arg Ser Gly Glu Gln Val Pro
         195                 200                 205

 ctt ctc cta aag atg aag agg agc aaa ctg gca cta agc aag gcc atc      729
 Leu Leu Leu Lys Met Lys Arg Ser Lys Leu Ala Leu Ser Lys Ala Ile
     210                 215                 220

 gag agc ggg gac act gac ctg gtg ttc acg gtg ttg ctg cac ctg aag      777
 Glu Ser Gly Asp Thr Asp Leu Val Phe Thr Val Leu Leu His Leu Lys
 225                 230                 235                 240

 aac gag ctg aac cga gga gat ttt ttc atg acc ctt cgg aat cag ccc      825
 Asn Glu Leu Asn Arg Gly Asp Phe Phe Met Thr Leu Arg Asn Gln Pro
                 245                 250                 255

 atg gcc ctc agt ttg tac cga cag ttc tgt aag cat cag gag cta gag      873
 Met Ala Leu Ser Leu Tyr Arg Gln Phe Cys Lys His Gln Glu Leu Glu
             260                 265                 270

 acg ctg aag gac ctt tac aat cag gat gac aat cac cag gaa ttg ggc      921
 Thr Leu Lys Asp Leu Tyr Asn Gln Asp Asp Asn His Gln Glu Leu Gly
         275                 280                 285

 agc ttc cac atc cga gcc agc tat gct gca gaa gag cgt att gag ggg      969
 Ser Phe His Ile Arg Ala Ser Tyr Ala Ala Glu Glu Arg Ile Glu Gly
     290                 295                 300

 cga gta gca gct ctg cag aca gcc gcc gat gcc ttc tac aag gcc aag     1017
 Arg Val Ala Ala Leu Gln Thr Ala Ala Asp Ala Phe Tyr Lys Ala Lys
 305                 310                 315                 320

 aat gag ttt gca gcc aag gct aca gag gat caa atg cgg ctc cta cgg     1065
 Asn Glu Phe Ala Ala Lys Ala Thr Glu Asp Gln Met Arg Leu Leu Arg
                 325                 330                 335

 ctg cag cgg cgc cta gaa gac gag ctg ggg ggc cag ttc cta gac ctg     1113
 Leu Gln Arg Arg Leu Glu Asp Glu Leu Gly Gly Gln Phe Leu Asp Leu
             340                 345                 350

 tct cta cat gac aca gtt acc acc ctc att ctt ggc ggt cac aac aag     1161
 Ser Leu His Asp Thr Val Thr Thr Leu Ile Leu Gly Gly His Asn Lys
         355                 360                 365

 cgt gca gag cag ctg gca cgt gac ttc cgc atc cct gac aag agg ctc     1209
 Arg Ala Glu Gln Leu Ala Arg Asp Phe Arg Ile Pro Asp Lys Arg Leu
     370                 375                 380

 tgg tgg ctg aag ctg act gcc ctg gca gat ttg gaa gat tgg gaa gag     1257
 Trp Trp Leu Lys Leu Thr Ala Leu Ala Asp Leu Glu Asp Trp Glu Glu
 385                 390                 395                 400

 cta gag aag ttt tcc aag agc aag aaa tca ccc att ggc tac ctg cct     1305
 Leu Glu Lys Phe Ser Lys Ser Lys Lys Ser Pro Ile Gly Tyr Leu Pro
                 405                 410                 415

 ttt gtg gag atc tgc atg aaa caa cat aac aaa tac gaa gcc aag aag     1353
 Phe Val Glu Ile Cys Met Lys Gln His Asn Lys Tyr Glu Ala Lys Lys
             420                 425                 430

 tat gct tcc cgc gtg ggt ccc gag cag aag gtc aag gct ttg ctt ctt     1401
 Tyr Ala Ser Arg Val Gly Pro Glu Gln Lys Val Lys Ala Leu Leu Leu
         435                 440                 445

 gtt ggc gat gtg gct cag gct gca gat gtg gcc atc gaa cac cgg aat     1449
 Val Gly Asp Val Ala Gln Ala Ala Asp Val Ala Ile Glu His Arg Asn
     450                 455                 460

 gag gct gag ctg agc ctc gta ttg tcc cac tgc acg gga gcc aca gat     1497
 Glu Ala Glu Leu Ser Leu Val Leu Ser His Cys Thr Gly Ala Thr Asp
 465                 470                 475                 480

 ggg gcc aca gct gac aag att caa cgg gcc agg gca caa gcc cag aag     1545
 Gly Ala Thr Ala Asp Lys Ile Gln Arg Ala Arg Ala Gln Ala Gln Lys
                 485                 490                 495

 aag tga ggagtccatc ctgtacatct caagcaaggg gttcctcccc tagcacctgg      1601
 Lys 


 gcttggcaga agggccatag ttcatccagc tcctccccta gagcaatgct gaggagcggg   1661

 ggcatggtag cagggctgtc tggttttaaa taaagttgga acacttcaaa aaaaaaaaaa   1721




      <210> 128
      <211> 2999
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (294)..(1079)

      <400> 128
 taagcttgcg gccgcgcagt gtggttcagc ccggactccg cggggcgagc tgcccttcct     60

 cccccgaccc ccgcgcaagt ggtgcattgg cgcgcggcgc cgaggggcgg ggcccgagcc    120

 gggcgcgcgc gggcgctgct ctataaatac cgggccgcac cgcccgctgc ttcgttcgct    180

 ccgcgccgcc cgcctgctac gagtagaacg ctgtccgcag cttgcgcatt tcgcagccgc    240

 tgccgcctcg ccgctgctcc ttcgtaaggc cacttccgca caccgacacc aac   atg     296
                                                              Met
                                                                1

 aac gga cag ctc aac ggc ttc cac gag gcg ttc atc gag gag ggc aca      344
 Asn Gly Gln Leu Asn Gly Phe His Glu Ala Phe Ile Glu Glu Gly Thr
               5                  10                  15

 ttc ctt ttc acc tca gag tcg gtc ggg gaa ggc cac cca gat aag att      392
 Phe Leu Phe Thr Ser Glu Ser Val Gly Glu Gly His Pro Asp Lys Ile
          20                  25                  30

 tgt gac caa atc agt gat gct gtc ctt gat gcc cac ctt cag cag gat      440
 Cys Asp Gln Ile Ser Asp Ala Val Leu Asp Ala His Leu Gln Gln Asp
      35                  40                  45

 cct gat gcc aaa gta gct tgt gaa act gtt gct aaa act gga atg atc      488
 Pro Asp Ala Lys Val Ala Cys Glu Thr Val Ala Lys Thr Gly Met Ile
  50                  55                  60                  65

 ctt ctt gct ggg gaa att aca tcc aga gct gct gtt gac tac cag aaa      536
 Leu Leu Ala Gly Glu Ile Thr Ser Arg Ala Ala Val Asp Tyr Gln Lys
                  70                  75                  80

 gtg gtt cgt gaa gct gtt aaa cac att gga tat gat gat tct tcc aaa      584
 Val Val Arg Glu Ala Val Lys His Ile Gly Tyr Asp Asp Ser Ser Lys
              85                  90                  95

 ggt ttt gac tac aag act tgt aac gtg ctg gta gcc ttg gag caa cag      632
 Gly Phe Asp Tyr Lys Thr Cys Asn Val Leu Val Ala Leu Glu Gln Gln
         100                 105                 110

 tca cca gat att gct caa ggt gtt cat ctt gac aga aat gaa gaa gac      680
 Ser Pro Asp Ile Ala Gln Gly Val His Leu Asp Arg Asn Glu Glu Asp
     115                 120                 125

 att ggt gct gga gac cag ggc tta atg ttt ggc tat gcc act gat gaa      728
 Ile Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Thr Asp Glu
 130                 135                 140                 145

 act gag gag tgt atg cct tta acc att gtc ttg gca cac aag cta aat      776
 Thr Glu Glu Cys Met Pro Leu Thr Ile Val Leu Ala His Lys Leu Asn
                 150                 155                 160

 gcc aaa ctg gca gaa cta cgc cgt aat ggc act ttg cct tgg tta cgc      824
 Ala Lys Leu Ala Glu Leu Arg Arg Asn Gly Thr Leu Pro Trp Leu Arg
             165                 170                 175

 cct gat tct aaa act caa gtt act gtg cag tat atg cag gat cga ggt      872
 Pro Asp Ser Lys Thr Gln Val Thr Val Gln Tyr Met Gln Asp Arg Gly
         180                 185                 190

 gct gtg ctt ccc atc aga gtc cac aca att gtt ata tct gtt cag cat      920
 Ala Val Leu Pro Ile Arg Val His Thr Ile Val Ile Ser Val Gln His
     195                 200                 205

 gat gaa gag gtt tgt ctt gat gaa atg agg gat gcc cta aag gag aaa      968
 Asp Glu Glu Val Cys Leu Asp Glu Met Arg Asp Ala Leu Lys Glu Lys
 210                 215                 220                 225

 gtc atc aaa gca gtt gtg cct gcg aaa tac ctt gat gag gat aca atc     1016
 Val Ile Lys Ala Val Val Pro Ala Lys Tyr Leu Asp Glu Asp Thr Ile
                 230                 235                 240

 tac cac cta cag cca agt ggc aga ttt gtt att ggt tgg gcc tca ggg     1064
 Tyr His Leu Gln Pro Ser Gly Arg Phe Val Ile Gly Trp Ala Ser Gly
             245                 250                 255

 gtg atg ctg gtt tga ctggacggaa aatcattgtg gacacttatg gcggttgggg     1119
 Val Met Leu Val 
         260

 gttgctcgag ggaggaggtg ccttttcagg aaaggattat accaaggtcg accgttcagc   1179

 tgcttatgct gctcgttggg tggcaaaatc ccttgttaaa ggaggtctgt gccggagggt   1239

 tcttgttcag gtctcttatg ctattggagt ttctcatcca ttatctatct ccattttcca   1299

 ttatggtacc tctcagaaga gtgagagaga gctattagag attgtgaaga agaatttcga   1359

 tctccgccct ggggtcattt cagggatctg gatctgaaga agccaattta tcagaggact   1419

 gcagcctatg gccactttgg tagggacagc ttcccatggg aagtgcccaa aaagcttaaa   1479

 tattgaaagt gttagccttt tttccccaga cttgttggcg taggctacag agaagccttc   1539

 aagctctgag ggaaagggcc ctccttccta aattttcctg tcctctttca gctcctgacc   1599

 agttgcagtc actctagtca atgacatgaa ttttagcttt tgtgggggac tgtaagttgg   1659

 gcttgctatt ctgtccctag gtgttttgtt caccattata atgaatttag tgagcatagg   1719

 tgatccatgt aactgcctag aaacaacact gtagtaaata atgctttgaa attgaacctt   1779

 tgtgccctat cacccaacgc tccaaagtca taattgcatt gactttcccc accagatgct   1839

 gaaaatgtcc ttgtgatgtg cacgtaaagt acttgtagtt ccacttatag cctctgtctg   1899

 gcaatgccac agccctgtca gcatgaattt gtaatgtctt gagctctatt atgaatgtga   1959

 agccttcccc ttatcctccc tgtaacttga tccatttcta attatgtagc tctttgtcag   2019

 ggagtgttcc ctatccaatc aatcttgcat gtaacgcaag ttcccagttg gagctccagc   2079

 ctgacatcaa aaaaggcagt taccattaaa ccatctccct ggtgcttatg ctcttaattg   2139

 ccacctctaa cagcaccaaa tcaaaatctc tccactttca gctgtctttt ggaggacgta   2199

 cgtaataagg ttttaattta gtaaaccaat cctatgcatg gtttcagcac tagccaaacc   2259

 tcaccaactc ctagttctag aaaaacaggc acttggcagc cttgtgatgt catacagaga   2319

 agtcacaggg cagtacctga gggtctgtag gttgcacact ttggtaccag ataacttttt   2379

 tttttcttta taagaaagcc tgagtactcc acactgcaca ataactcctc ccagggtttt   2439

 aactttgttt tattttcaaa accaggtcca atgagctttc tgaacagctg gtgtagctac   2499

 agagaaacca gcttccttca gagagcagtg cttttggcgg ggaggaggaa atcccttcat   2559

 acttgaacgt tttctaattg cttatttatt gtattctggg gtatggcgta agtacagaga   2619

 agccatcacc tcagatggca gcttttaaaa gatttttttt ttttctctca acaccatgat   2679

 tcctttaaca acatgtttcc agcattccca ggtaggccaa ggtgtcctac agaaaaacct   2739

 tgggttagac ctacaggggg tctggctggt gttaacagaa gggagggcag agctggtgcg   2799

 gctggccatg gagaaagctg acttggctgg tgtggtacag agaagccagc ttgtttacat   2859

 gcttattcca tgactgcttg ccctaagcag aaagtgcctt tcaggatcta tttttggagg   2919

 tttattacgt atgtctggtt ctcaattcca acagtttaat gaagatctaa ataaaatgct   2979

 aggttctaaa aaaaaaaaaa                                               2999




      <210> 129
      <211> 1292
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (424)..(1242)

      <400> 129
 tatattttat tagtttcatt aatgaaattt taatagcaat aaattcaggc ttttaaatat     60

 tacaaagtat tttcaaatat ctcatggggc cttgatgtta gcttcaggaa gtatctagca    120

 acctaatggc tgtttgatta gacttctcag actattatta tccttgtcac ataatagtgc    180

 tttagtccat gtatcatagg atcttcaagt attattcatt tgtttccaaa gcaaattgag    240

 ctattccact caaatgatta cagtaaatag aatagaaact tgtggaatca tcttcctctc    300

 tcgtaaatga agtaacagca aaatagcgca gcatctcagc tgttccaggt tcctcaaata    360

 agttttactt ttgcaaaacc aacctcaaac ttcctatatt ctctgttctg cattataagc    420

 aac  atg acc agc agc cac gtt tgt tgt aat ttt tta aat atg tgg aaa     468
      Met Thr Ser Ser His Val Cys Cys Asn Phe Leu Asn Met Trp Lys
        1               5                  10                  15

 aaa agc aag ata tca acc atg tat tac ctt aac caa gat gcc aaa tta      516
 Lys Ser Lys Ile Ser Thr Met Tyr Tyr Leu Asn Gln Asp Ala Lys Leu
                  20                  25                  30

 tct aac ttg ttt ctc cag gca agc agc cca aca aca ggg aca gct ccc      564
 Ser Asn Leu Phe Leu Gln Ala Ser Ser Pro Thr Thr Gly Thr Ala Pro
              35                  40                  45

 agg agc cag tca agg ttg tct gtc tgt cca tcc act cag gac atc tgc      612
 Arg Ser Gln Ser Arg Leu Ser Val Cys Pro Ser Thr Gln Asp Ile Cys
          50                  55                  60

 aga atc tgt cac tgc gaa ggg gat gaa gag agc ccc ctc atc aca ccc      660
 Arg Ile Cys His Cys Glu Gly Asp Glu Glu Ser Pro Leu Ile Thr Pro
      65                  70                  75

 tgt cgc tgc act ggg aca ctg cgc ttt gtc cac cag tcc tgc ctc cac      708
 Cys Arg Cys Thr Gly Thr Leu Arg Phe Val His Gln Ser Cys Leu His
  80                  85                  90                  95

 cag tgg ata aag agc tca gat aca cgc tgc tgt gag ctc tgc aag tat      756
 Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr
                 100                 105                 110

 gac ttc ata atg gag acc aag ctc aaa ccc ctc cgg aag tgg gag aaa      804
 Asp Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys
             115                 120                 125

 cta cag atg acc aca agt gaa agg agg aaa ata ttc tgc tct gtc aca      852
 Leu Gln Met Thr Thr Ser Glu Arg Arg Lys Ile Phe Cys Ser Val Thr
         130                 135                 140

 ttc cac gta atc gcg atc acc tgt gtg gtt tgg tct ttg tat gta ttg      900
 Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu
     145                 150                 155

 ata gac cgg aca gcg gag gaa atc aag caa ggc aat gac aat ggt gtc      948
 Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Asn Asp Asn Gly Val
 160                 165                 170                 175

 ctt gaa tgg cca ttt tgg aca aaa ctg gtt gtg gta gcc att ggc ttc      996
 Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe
                 180                 185                 190

 aca gga ggt ctt gtc ttc atg tac gta cag tgt aaa gtc tat gtt cag     1044
 Thr Gly Gly Leu Val Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln
             195                 200                 205

 ttg tgg cgc agg ctg aag gcc tac aac cgt gtg atc ttt gta caa aat     1092
 Leu Trp Arg Arg Leu Lys Ala Tyr Asn Arg Val Ile Phe Val Gln Asn
         210                 215                 220

 tgc cca gac act gcc aaa aaa ctg gag aag aac ttc tca tgt aat gta     1140
 Cys Pro Asp Thr Ala Lys Lys Leu Glu Lys Asn Phe Ser Cys Asn Val
     225                 230                 235

 aac aca gac atc aaa gat gct gtg gta gtg cct gta cca caa aca ggt     1188
 Asn Thr Asp Ile Lys Asp Ala Val Val Val Pro Val Pro Gln Thr Gly
 240                 245                 250                 255

 gca aat tca ctg cca tct gca gag ggt ggc ccc cct gaa gtt gta tca     1236
 Ala Asn Ser Leu Pro Ser Ala Glu Gly Gly Pro Pro Glu Val Val Ser
                 260                 265                 270

 gtc tga tggaacctgt tgggagtttc ttcaccgaag aatatctttc tagccctcag      1292
 Val 






      <210> 130
      <211> 1229
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (419)..(856)

      <400> 130
 taagcttgcg gccgcgtgcg gacagccatg cattaggcag ggcttcccta tgcgcccgga     60

 gagcgcggac cgctgcctcg ggccgccgcc gcctgccgcc gctcgcggag cccgagcccc    120

 agcccgagcc gccgcctgcc ccaggccggg gcgtcgagca gccggcggcc tggccatgtg    180

 gggctagccc tcgccgcgcc tggcctgcag caggaccagc aacatggagg ctgccgtcgg    240

 cgtccccgac ggcggggacc agggcggcgc ggggccccgc gaggacgcga cgcccatgga    300

 cgcctatctg cggaaactgg gcttgtatcg gaaactggtc gccaaggacg ggtcgtgcct    360

 gttccgggcc gtggcggagc aggtattgca ctctcagtct cgccatgttg aagtcaga      418                                                                 
 atg gcc tgt att cac tat ctt cga gag aac aga gag aaa ttt gaa gcg      466
 Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala
   1               5                  10                  15

 ttt ata gaa gga tca ttt gaa gaa tat tta aag cgt ttg gaa aat cca      514
 Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro
              20                  25                  30

 cag gaa tgg gta gga caa gtg gaa ata agt gcc ctt tct ctt atg tac      562
 Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr
          35                  40                  45

 agg aaa gat ttt ata att tat cgg gaa cca aat gtt tct cct tca caa      610
 Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln
      50                  55                  60

 gta aca gaa aat aat ttt cct gaa aag gtg tta ctg tgt ttt tca aat      658
 Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn
  65                  70                  75                  80

 gga aat cat tat gat att gtg tat ccc ata aag tat aaa gaa agc tct      706
 Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser
                  85                  90                  95

 gct atg tgt cag tct ctc ctt tat gaa ttg ctg tat gag aag gta ttt      754
 Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe
             100                 105                 110

 aaa act gat gtt agt aaa att gtg atg gaa cta gac acg ttg gaa gta      802
 Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val
         115                 120                 125

 gct gat gaa gat aac agt gaa ata tca gat tca gag gat gac agt tgc      850
 Ala Asp Glu Asp Asn Ser Glu Ile Ser Asp Ser Glu Asp Asp Ser Cys
     130                 135                 140

 aag taa gaatgaaatc ctaaaatacc tttcttagtg ccatacaagg aaagttaagt       906
 Lys 
 145

 aaatgtcttt acatttcagt aatgtctttc tataacatat attgaggtat taatggtatt    966

 cataaaatac agcagtctgc tgaagtttct ttatccctgt cactaatttt acctaatttc   1026

 tattatggga ctgtttgttt tgaaagttgg tgtttttggt tgatgagaat ttacgtctgc   1086

 aatctagatg catatttgta gaataaattt ggtcctacct atatgtgtgt gtattgtaaa   1146

 attttaaagt taacttgtca attgttcaca tacccagtaa tgaaataaaa tggccgtttg   1206

 gatttccttc aaaaaaaaaa aaa                                           1229




      <210> 131
      <211> 1252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(940)

      <400> 131
 gggcgcttta gggactggac ttgcagtgta aacagagacg ctgcaaattg cttgtggacg     60

 gtgtaggccg ctgcaggcca cc atg aac cgg ctt ccg gat gac tac gac ccc     112
                          Met Asn Arg Leu Pro Asp Asp Tyr Asp Pro
                            1               5                  10

 tac gcg gtt gaa gag cct agc gac gag gag ccg gct ttg agc agc tct      160
 Tyr Ala Val Glu Glu Pro Ser Asp Glu Glu Pro Ala Leu Ser Ser Ser
                  15                  20                  25

 gag gat gaa gtg gat gtg ctt tta cat gga act cct gac caa aaa cga      208
 Glu Asp Glu Val Asp Val Leu Leu His Gly Thr Pro Asp Gln Lys Arg
              30                  35                  40

 aaa ctc atc aga gaa tgt ctt acc gga gaa agt gaa tca tct agt gaa      256
 Lys Leu Ile Arg Glu Cys Leu Thr Gly Glu Ser Glu Ser Ser Ser Glu
          45                  50                  55

 gat gaa ttt gaa aag gag atg gaa gct gaa tta aat tct acc atg aaa      304
 Asp Glu Phe Glu Lys Glu Met Glu Ala Glu Leu Asn Ser Thr Met Lys
      60                  65                  70

 aca atg gag gac aag tta tcc tct ctg gga act gga tct tcc tca gga      352
 Thr Met Glu Asp Lys Leu Ser Ser Leu Gly Thr Gly Ser Ser Ser Gly
  75                  80                  85                  90

 aat gga aaa gtt gca aca gct ccg aca agg tac tac gat gat ata tat      400
 Asn Gly Lys Val Ala Thr Ala Pro Thr Arg Tyr Tyr Asp Asp Ile Tyr
                  95                 100                 105

 ttt gat tct gat tcc gag gat gaa gac aga gca gta cag gtg acc aag      448
 Phe Asp Ser Asp Ser Glu Asp Glu Asp Arg Ala Val Gln Val Thr Lys
             110                 115                 120

 aaa aaa aag aag aaa caa cac aag att cca aca aat gac gaa tta ctg      496
 Lys Lys Lys Lys Lys Gln His Lys Ile Pro Thr Asn Asp Glu Leu Leu
         125                 130                 135

 tat gat cct gaa aaa gat aac aga gat cag gcc tgg gtt gat gca cag      544
 Tyr Asp Pro Glu Lys Asp Asn Arg Asp Gln Ala Trp Val Asp Ala Gln
     140                 145                 150

 aga agg ggt tac cat ggt ttg gga cca cag aga tca cgt gaa caa cag      592
 Arg Arg Gly Tyr His Gly Leu Gly Pro Gln Arg Ser Arg Glu Gln Gln
 155                 160                 165                 170

 cct gtt cca aat agt gat gct gtc ttg aat tgt cct gcc tgc atg acc      640
 Pro Val Pro Asn Ser Asp Ala Val Leu Asn Cys Pro Ala Cys Met Thr
                 175                 180                 185

 aca ctt tgc ctt gat tgc caa agg cat gaa tca tac aaa act caa tat      688
 Thr Leu Cys Leu Asp Cys Gln Arg His Glu Ser Tyr Lys Thr Gln Tyr
             190                 195                 200

 aga gca atg ttt gta atg aat tgt tct att aac aaa gag gag gtt cta      736
 Arg Ala Met Phe Val Met Asn Cys Ser Ile Asn Lys Glu Glu Val Leu
         205                 210                 215

 aga tat aaa gcc tca gag aac agg aag aaa agg cgg gtc cat aag aag      784
 Arg Tyr Lys Ala Ser Glu Asn Arg Lys Lys Arg Arg Val His Lys Lys
     220                 225                 230

 atg agg tct aac cgg gaa gat gct gct gag aag gca gag aca gat gtg      832
 Met Arg Ser Asn Arg Glu Asp Ala Ala Glu Lys Ala Glu Thr Asp Val
 235                 240                 245                 250

 gaa gaa atc tat cac cca gtc atg tgc act gaa tgt tcc act gaa gtg      880
 Glu Glu Ile Tyr His Pro Val Met Cys Thr Glu Cys Ser Thr Glu Val
                 255                 260                 265

 gca gtc tac gac aag gat gaa gtc ttt cat ttt ttc aat gtt tta gca      928
 Ala Val Tyr Asp Lys Asp Glu Val Phe His Phe Phe Asn Val Leu Ala
             270                 275                 280

 agc cat tcc taa aca gcccaactgg catttaatta cccaatactg tatataaggc      983
 Ser His Ser 
         285

 aaatatggac agttactttc ctcttgcctg ttcatatcct tcagtgacat tgaggaagca   1043

 gtgtttctct ttttaaagga gaatagttgt caaccttcat tcatctctta catctctcac   1103

 cctctccttt ttttttttct ttgattttcc cccttattga tgggactgat attcattctg   1163

 tttttgatga acatttggaa actgtcgggc tttttattaa agctctgtag aattaaaatg   1223

 ttctggaatt ataagcaaaa aaaaaaaaa                                     1252




      <210> 132
      <211> 509
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(286)

      <220>
      <221> misc_feature
      <222> (1)...(509)
      <223> n = a,t,c or g

      <400> 132
 gggcgnacct ctggtggac atg gct gct tcc cgc tta ccc cca gcg acg cta      52
                      Met Ala Ala Ser Arg Leu Pro Pro Ala Thr Leu
                        1               5                  10

 acg tta aag cag ttc gta aga agg caa caa gtt ctt ctc ctc tac aga      100
 Thr Leu Lys Gln Phe Val Arg Arg Gln Gln Val Leu Leu Leu Tyr Arg
              15                  20                  25

 agg att ttg caa aca att cgg caa gtt cca aat gat tct gat cgc aaa      148
 Arg Ile Leu Gln Thr Ile Arg Gln Val Pro Asn Asp Ser Asp Arg Lys
          30                  35                  40

 tac ctg gaa gat tgg gca aga gaa gaa ttc aga aga aac aaa agt gcc      196
 Tyr Leu Glu Asp Trp Ala Arg Glu Glu Phe Arg Arg Asn Lys Ser Ala
      45                  50                  55

 acc gaa gag gat aca atc cgg atg atg att act caa ggc aat atg cag      244
 Thr Glu Glu Asp Thr Ile Arg Met Met Ile Thr Gln Gly Asn Met Gln
  60                  65                  70                  75

 ctc aag gag tta gaa aaa aca ctt gct tta gca aaa tct taa ctatagc      293
 Leu Lys Glu Leu Glu Lys Thr Leu Ala Leu Ala Lys Ser 
                  80                  85

 attattctga aggattttca aagtctccat gtgttttgtt gcatttagga ttaacaatgg    353

 acaacacaaa gcccagtctt actatttata tgtacagtat ttggtgatag agagcaaagg    413

 aaaaacacat cagaacagtt gccttaacac tgaaaaacat accctgcatt ttgaaaatgt    473

 ttatggatgt ctcagcagtt cttaaaaaaa aaaaaa                              509




      <210> 133
      <211> 2813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(2262)

      <400> 133
 agctccggaa ttcccgggtc gacttcgctg tcgacgattt cgtctgtcgt tgttctgaga     60

 ggtgaaagtc ttcaggatca ggaatcaatt catttacagc tttccagttt ttccagcctg    120

 caagaggagg ataaatctag gaaagatgac tctgaaagag aaaaagaaaa ggataaaaac    180

 aaagataaaa cctctgaaaa acccaagatc aga atg tta tca aaa gat tgc agc     234
                                      Met Leu Ser Lys Asp Cys Ser
                                        1               5

 caa gaa tac acg gat tct aca ggc ata gac tta cac gag ttt ctg att      282
 Gln Glu Tyr Thr Asp Ser Thr Gly Ile Asp Leu His Glu Phe Leu Ile
          10                  15                  20

 aac aca tta aag aat aat tcc agg gac agg atg ata ctt ttg aaa atg      330
 Asn Thr Leu Lys Asn Asn Ser Arg Asp Arg Met Ile Leu Leu Lys Met
      25                  30                  35

 gag cag gaa att att gat ttc att gct gac aac aat aat cat tat aaa      378
 Glu Gln Glu Ile Ile Asp Phe Ile Ala Asp Asn Asn Asn His Tyr Lys
  40                  45                  50                  55

 aag ttc cct cag atg tca tcg tat cag agg atg ctt gtc cat cga gtg      426
 Lys Phe Pro Gln Met Ser Ser Tyr Gln Arg Met Leu Val His Arg Val
                  60                  65                  70

 gca gct tat ttt gga ttg gat cac aat gtg gat caa aca gga aaa tct      474
 Ala Ala Tyr Phe Gly Leu Asp His Asn Val Asp Gln Thr Gly Lys Ser
              75                  80                  85

 gtt atc atc aac aag acc agc agc acc aga ata cca gag caa agg ttt      522
 Val Ile Ile Asn Lys Thr Ser Ser Thr Arg Ile Pro Glu Gln Arg Phe
          90                  95                 100

 tgt gaa cat tta aaa gat gaa aaa ggt gaa gaa tcc cag aag cgg ttt      570
 Cys Glu His Leu Lys Asp Glu Lys Gly Glu Glu Ser Gln Lys Arg Phe
     105                 110                 115

 atc ttg aag cga gat aac tct agt att gat aaa gaa gac aat cag tca      618
 Ile Leu Lys Arg Asp Asn Ser Ser Ile Asp Lys Glu Asp Asn Gln Ser
 120                 125                 130                 135

 gtt tgc tcc cag gaa agc ctt ttt gtg gaa aac agt agg ctc ttg gaa      666
 Val Cys Ser Gln Glu Ser Leu Phe Val Glu Asn Ser Arg Leu Leu Glu
                 140                 145                 150

 gac agt aac ata tgc aat gag acc tat aag aaa aga cag ctc ttt cgg      714
 Asp Ser Asn Ile Cys Asn Glu Thr Tyr Lys Lys Arg Gln Leu Phe Arg
             155                 160                 165

 ggc aac aga gat ggc tca ggg aga aca tct ggg agt cga cag agc agc      762
 Gly Asn Arg Asp Gly Ser Gly Arg Thr Ser Gly Ser Arg Gln Ser Ser
         170                 175                 180

 tca gaa aat gaa ctc aag tgg tct gac cac caa agg gcc tgg agc agc      810
 Ser Glu Asn Glu Leu Lys Trp Ser Asp His Gln Arg Ala Trp Ser Ser
     185                 190                 195

 aca gac tcc gac agt tcc aac cgc aat cta aag ccc gcc atg acc aag      858
 Thr Asp Ser Asp Ser Ser Asn Arg Asn Leu Lys Pro Ala Met Thr Lys
 200                 205                 210                 215

 acg gcg agt ttt ggg ggc atc acg gtg ctg acc agg ggt gac agc act      906
 Thr Ala Ser Phe Gly Gly Ile Thr Val Leu Thr Arg Gly Asp Ser Thr
                 220                 225                 230

 tcc agt act agg agt acc ggg aag ctg tcc aaa gca ggt tcc gag tct      954
 Ser Ser Thr Arg Ser Thr Gly Lys Leu Ser Lys Ala Gly Ser Glu Ser
             235                 240                 245

 tcc agc agt gca ggc tcc tca gga tcg ctg tcc cgc acc cat cca cct     1002
 Ser Ser Ser Ala Gly Ser Ser Gly Ser Leu Ser Arg Thr His Pro Pro
         250                 255                 260

 ctc cag agc aca ccc cta gtc tca ggt gtg gca gct ggc tct cca ggc     1050
 Leu Gln Ser Thr Pro Leu Val Ser Gly Val Ala Ala Gly Ser Pro Gly
     265                 270                 275

 tgt gtg cct tat cca gag aat gga ata ggg ggc cag gtt gct ccc agc     1098
 Cys Val Pro Tyr Pro Glu Asn Gly Ile Gly Gly Gln Val Ala Pro Ser
 280                 285                 290                 295

 agc acc agc tac atc ctc ctt cca ctt gaa gct gca aca ggc atc ccg     1146
 Ser Thr Ser Tyr Ile Leu Leu Pro Leu Glu Ala Ala Thr Gly Ile Pro
                 300                 305                 310

 cct gga agc atc ctt ctt aat cca cac aca ggc cag ccc ttt gtg aat     1194
 Pro Gly Ser Ile Leu Leu Asn Pro His Thr Gly Gln Pro Phe Val Asn
             315                 320                 325

 ccc gat gga act cct gca ata tac aac cca ccc acc agt cag cag ccc     1242
 Pro Asp Gly Thr Pro Ala Ile Tyr Asn Pro Pro Thr Ser Gln Gln Pro
         330                 335                 340

 ctg cga agc gcc atg gtg ggg cag tcc caa cag cag ccg cca cag cag     1290
 Leu Arg Ser Ala Met Val Gly Gln Ser Gln Gln Gln Pro Pro Gln Gln
     345                 350                 355

 cag ccc tcc ccg cag ccc caa cag cag gtc cag cca ccg cag cca cag     1338
 Gln Pro Ser Pro Gln Pro Gln Gln Gln Val Gln Pro Pro Gln Pro Gln
 360                 365                 370                 375

 atg gca ggc cct ctg gtc act cag tct gtc cag ggg ctg cag gct tcc     1386
 Met Ala Gly Pro Leu Val Thr Gln Ser Val Gln Gly Leu Gln Ala Ser
                 380                 385                 390

 tcc cag tca gtg caa tat cca gca gtc tct ttt cct ccc cag cac ctc     1434
 Ser Gln Ser Val Gln Tyr Pro Ala Val Ser Phe Pro Pro Gln His Leu
             395                 400                 405

 cta cct gtg tct cca acg cag cac ttt ccc atg aga gat gat gtg gca     1482
 Leu Pro Val Ser Pro Thr Gln His Phe Pro Met Arg Asp Asp Val Ala
         410                 415                 420

 aca cag ttt ggc cag atg acc ctg agc cgg cag tcc tcg ggg gag act     1530
 Thr Gln Phe Gly Gln Met Thr Leu Ser Arg Gln Ser Ser Gly Glu Thr
     425                 430                 435

 cct gaa ccc cca tca ggt cct gtc tac cca tcc tcc ctt atg cca cag     1578
 Pro Glu Pro Pro Ser Gly Pro Val Tyr Pro Ser Ser Leu Met Pro Gln
 440                 445                 450                 455

 ccg gcc cag cag ccc agc tat gta atc gcc tct aca ggc cag cag ctt     1626
 Pro Ala Gln Gln Pro Ser Tyr Val Ile Ala Ser Thr Gly Gln Gln Leu
                 460                 465                 470

 cct aca gga gga ttc tca ggc tct ggc cct ccc atc tcc cag cag gtc     1674
 Pro Thr Gly Gly Phe Ser Gly Ser Gly Pro Pro Ile Ser Gln Gln Val
             475                 480                 485

 ctc cag ccc cct ccc tca cca cag gga ttt gtg caa cag cct ccg cct     1722
 Leu Gln Pro Pro Pro Ser Pro Gln Gly Phe Val Gln Gln Pro Pro Pro
         490                 495                 500

 gca cag atg cct gta tat tat tac cca tct ggt cag tac cct acc tca     1770
 Ala Gln Met Pro Val Tyr Tyr Tyr Pro Ser Gly Gln Tyr Pro Thr Ser
     505                 510                 515

 acc acg caa cag tac cgg ccc atg gcc ccg gtt cag tac aac gct cag     1818
 Thr Thr Gln Gln Tyr Arg Pro Met Ala Pro Val Gln Tyr Asn Ala Gln
 520                 525                 530                 535

 agg agt caa cag atg cca cag gca gca cag caa gca ggt tac cag cca     1866
 Arg Ser Gln Gln Met Pro Gln Ala Ala Gln Gln Ala Gly Tyr Gln Pro
                 540                 545                 550

 gtc ttg tct ggt caa cag gga ttc caa ggc cta ata gga gtg cag cag     1914
 Val Leu Ser Gly Gln Gln Gly Phe Gln Gly Leu Ile Gly Val Gln Gln
             555                 560                 565

 cca cct cag agt cag aac gtg ata aat aac caa caa gga act ccg gtg     1962
 Pro Pro Gln Ser Gln Asn Val Ile Asn Asn Gln Gln Gly Thr Pro Val
         570                 575                 580

 caa agc gtg atg gtt tcc tac cca aca atg tct tct tat cag gtg cca     2010
 Gln Ser Val Met Val Ser Tyr Pro Thr Met Ser Ser Tyr Gln Val Pro
     585                 590                 595

 atg acc cag ggt tct caa gga ctg ccc cag cag tca tac caa cag cca     2058
 Met Thr Gln Gly Ser Gln Gly Leu Pro Gln Gln Ser Tyr Gln Gln Pro
 600                 605                 610                 615

 atc atg cta cct aac cag gca ggt caa ggg tca ctc cca gcc act gga     2106
 Ile Met Leu Pro Asn Gln Ala Gly Gln Gly Ser Leu Pro Ala Thr Gly
                 620                 625                 630

 atg cct gtt tac tgt aat gtc aca ccg ccc acc cct cag aac aac ctt     2154
 Met Pro Val Tyr Cys Asn Val Thr Pro Pro Thr Pro Gln Asn Asn Leu
             635                 640                 645

 agg ctg att ggc cca cac tgc ccc tcc agc act gtc cca gtg atg tca     2202
 Arg Leu Ile Gly Pro His Cys Pro Ser Ser Thr Val Pro Val Met Ser
         650                 655                 660

 gct agc tgc aga aca aac tgt gca agt atg agc aat gct ggt tgg cag     2250
 Ala Ser Cys Arg Thr Asn Cys Ala Ser Met Ser Asn Ala Gly Trp Gln
     665                 670                 675

 gtc aaa ttc tga gag ctctggctgt ggtacatttc ttcagatatt tctcatggcc     2305
 Val Lys Phe 
 680

 tttgatggaa gaggaacaag gtgggaaaac tggctgagga cttaagtatt cactcaacac   2365

 tcaaatgatt gctgctggta ttctgtaaaa aataaacaaa gactaatata cacgttagct   2425

 ggttaatggt gcatatttct gtcatgtctg ctaggtatgc ctttatagct tagctagtga   2485

 catgaattca tcaaggtaag attttctcct accactgaat accactgtgt agattataat   2545

 atccctaatt tggattagtt ttgtactttg tgttgagttt gtgatgctaa aagtatttaa   2605

 aaattatata ctaaatcaca ttgtaccaaa gctgtaatgg aaaagcaaag aagaattgat   2665

 gaattgaagg aataatttat atacattata gagttttctt ttttaatgga tatatactgt   2725

 attgtagtgt ttaatcaaaa taaaactatt tgaccttatg gaggaaggtc atgtttttac   2785

 caccagtttg gttcaaaaaa aaaaaaaa                                      2813




      <210> 134
      <211> 1167
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(977)

      <400> 134
 atttggccct cgacgggaat tcggcacgag gcacgtggcc tccgagcagc tcagggcgcc     60

 cttgaaagtt cttggatctg cgggtt atg gcc ggt ccc ttg cag ggc ggt ggg     113
                              Met Ala Gly Pro Leu Gln Gly Gly Gly
                                1               5

 gcc cgg gcc ctg gac cta ctc cgg ggc ctg ccg cgt gtg agc ctg gcc      161
 Ala Arg Ala Leu Asp Leu Leu Arg Gly Leu Pro Arg Val Ser Leu Ala
  10                  15                  20                  25

 aac tta aag ccg aat ccc ggc tcc aag aaa ccg gag aga aga cca aga      209
 Asn Leu Lys Pro Asn Pro Gly Ser Lys Lys Pro Glu Arg Arg Pro Arg
                  30                  35                  40

 ggt cgg aga aga ggt aga aaa tgt ggc aga ggc cat aaa gga gaa agg      257
 Gly Arg Arg Arg Gly Arg Lys Cys Gly Arg Gly His Lys Gly Glu Arg
              45                  50                  55

 caa aga gga acc cgg ccc cgc ttg ggc ttt gag gga ggc cag act cca      305
 Gln Arg Gly Thr Arg Pro Arg Leu Gly Phe Glu Gly Gly Gln Thr Pro
          60                  65                  70

 ttt tac atc cga atc cca aaa tac ggg ttt aac gaa gga cat agt ttc      353
 Phe Tyr Ile Arg Ile Pro Lys Tyr Gly Phe Asn Glu Gly His Ser Phe
      75                  80                  85

 aga cgc cag tat aag cct ttg agt ctc aat aga ctg cag tat ctt att      401
 Arg Arg Gln Tyr Lys Pro Leu Ser Leu Asn Arg Leu Gln Tyr Leu Ile
  90                  95                 100                 105

 gat ttg ggt cgt gtt gat cct agt caa cct att gac tta acc cag ctt      449
 Asp Leu Gly Arg Val Asp Pro Ser Gln Pro Ile Asp Leu Thr Gln Leu
                 110                 115                 120

 gtc aat ggg aga ggt gtg acc atc cag cca ctt aaa agg gat tat ggt      497
 Val Asn Gly Arg Gly Val Thr Ile Gln Pro Leu Lys Arg Asp Tyr Gly
             125                 130                 135

 gtc cag ctg gtt gag gag ggt gct gac acc ttt acg gca aaa gtt aat      545
 Val Gln Leu Val Glu Glu Gly Ala Asp Thr Phe Thr Ala Lys Val Asn
         140                 145                 150

 att gaa gta cag ttg gct tca gaa cta gct att gct gcc att gaa aaa      593
 Ile Glu Val Gln Leu Ala Ser Glu Leu Ala Ile Ala Ala Ile Glu Lys
     155                 160                 165

 aat ggt ggt gtt gtt act aca gcc ttc tat gat cca aga agt ctg gac      641
 Asn Gly Gly Val Val Thr Thr Ala Phe Tyr Asp Pro Arg Ser Leu Asp
 170                 175                 180                 185

 att gta tgc aaa cct gtt cca ttc ttt ctt cgt gga caa ccc att cca      689
 Ile Val Cys Lys Pro Val Pro Phe Phe Leu Arg Gly Gln Pro Ile Pro
                 190                 195                 200

 aaa aga atg ctt cca cca gaa gaa ctg gta cca tat tac act gat gca      737
 Lys Arg Met Leu Pro Pro Glu Glu Leu Val Pro Tyr Tyr Thr Asp Ala
             205                 210                 215

 aag aac cgt ggg tac ctg gcg gat cct gcc aaa ttt cct gaa gca cga      785
 Lys Asn Arg Gly Tyr Leu Ala Asp Pro Ala Lys Phe Pro Glu Ala Arg
         220                 225                 230

 ctt gaa ctc gcc agg aag tat ggt tat atc tta cct gat atc act aaa      833
 Leu Glu Leu Ala Arg Lys Tyr Gly Tyr Ile Leu Pro Asp Ile Thr Lys
     235                 240                 245

 gat gaa ctc ttc aaa atg ctc tgt act agg aag gat cca agg cag att      881
 Asp Glu Leu Phe Lys Met Leu Cys Thr Arg Lys Asp Pro Arg Gln Ile
 250                 255                 260                 265

 ttc ttt ggt ctt gct cca gga tgg gtg gtg aat atg gcc gat aag aaa      929
 Phe Phe Gly Leu Ala Pro Gly Trp Val Val Asn Met Ala Asp Lys Lys
                 270                 275                 280

 atc cta aaa cct aca gat gaa aat ctc ctt aag tat tat acc tca tga      977
 Ile Leu Lys Pro Thr Asp Glu Asn Leu Leu Lys Tyr Tyr Thr Ser 
             285                 290                 295

 attcccgtcc aaggaagcag agttgttaaa gagtactgga ataggggctg aaggatctat   1037

 attcccttat tgcattttcc ttatgtataa ttttccagat ggtgatgtta cttttcagtg   1097

 tactcatatg tctcattttc atctaaaatt aaatggcagg aaacaaggac tgcatagaaa   1157

 aaaaaaaaaa                                                          1167




      <210> 135
      <211> 1473
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(1430)

      <400> 135
 ctcgtgctgc ctaggagaca agacgcgagg ccggcagcgc ccacccggtc gca   atg      56
                                                              Met
                                                                1

 gag ctt ccc cta ggg cgg tgc gat gat tcc cgc acc tgg gac gat gac      104
 Glu Leu Pro Leu Gly Arg Cys Asp Asp Ser Arg Thr Trp Asp Asp Asp
               5                  10                  15

 tcg gac cca gag tca gag aca gac cca gac gcg cag gcc aag gcc tac      152
 Ser Asp Pro Glu Ser Glu Thr Asp Pro Asp Ala Gln Ala Lys Ala Tyr
          20                  25                  30

 gtg gcc cgc gtt ctc agt ccg cca aaa tcc ggg ctg gcg ttc tcg cgc      200
 Val Ala Arg Val Leu Ser Pro Pro Lys Ser Gly Leu Ala Phe Ser Arg
      35                  40                  45

 ccc tcg cag cta tcc aca ccc gcc gcg tcc ccg agc gct tcg gag cct      248
 Pro Ser Gln Leu Ser Thr Pro Ala Ala Ser Pro Ser Ala Ser Glu Pro
  50                  55                  60                  65

 cgg gcc gcg tcc agg gtt tcg gcc gta agt gag ccg ggc ctt ctg agc      296
 Arg Ala Ala Ser Arg Val Ser Ala Val Ser Glu Pro Gly Leu Leu Ser
                  70                  75                  80

 ctt ccc ccg gag ctg ctg ctc gag atc tgc tcc tac ctg gac gcc cgc      344
 Leu Pro Pro Glu Leu Leu Leu Glu Ile Cys Ser Tyr Leu Asp Ala Arg
              85                  90                  95

 ctc gtg ctc cac gtc ctg tcg cgg gtg tgc cac gcg ctc cgc gac ctc      392
 Leu Val Leu His Val Leu Ser Arg Val Cys His Ala Leu Arg Asp Leu
         100                 105                 110

 gtg tct gac cat gtc acc tgg agg cta cgc gcg cta cgc cgc gta cgc      440
 Val Ser Asp His Val Thr Trp Arg Leu Arg Ala Leu Arg Arg Val Arg
     115                 120                 125

 gcg ccc tac cca gtg gtg gaa gag aag aac ttt gac tgg ccg gca gcc      488
 Ala Pro Tyr Pro Val Val Glu Glu Lys Asn Phe Asp Trp Pro Ala Ala
 130                 135                 140                 145

 tgc att gcg ctg gag cag cac ctg tcc cgc tgg gca gag gat ggg cgc      536
 Cys Ile Ala Leu Glu Gln His Leu Ser Arg Trp Ala Glu Asp Gly Arg
                 150                 155                 160

 tgg gtc gaa tac ttc tgc ctg gcc gaa ggc cac gtg gct tcc gtt gac      584
 Trp Val Glu Tyr Phe Cys Leu Ala Glu Gly His Val Ala Ser Val Asp
             165                 170                 175

 tca gtg ctg ctg ctc cag ggt ggg tca ctc tgt ctg tcg ggc tcc cga      632
 Ser Val Leu Leu Leu Gln Gly Gly Ser Leu Cys Leu Ser Gly Ser Arg
         180                 185                 190

 gat cgc aac gtc aac ttg tgg gac ctg cgg cag ctg ggg acg gag tcc      680
 Asp Arg Asn Val Asn Leu Trp Asp Leu Arg Gln Leu Gly Thr Glu Ser
     195                 200                 205

 aac cag gtt ctg atc aag acc tta ggc act aag cga aat agt acc cat      728
 Asn Gln Val Leu Ile Lys Thr Leu Gly Thr Lys Arg Asn Ser Thr His
 210                 215                 220                 225

 gag ggc tgg gtg tgg tca ctg gca gcg cag gac cac cgc gtg tgc tcc      776
 Glu Gly Trp Val Trp Ser Leu Ala Ala Gln Asp His Arg Val Cys Ser
                 230                 235                 240

 ggc tcc tgg gac agc aca gtg aag ctc tgg gac atg gca gcg gat ggg      824
 Gly Ser Trp Asp Ser Thr Val Lys Leu Trp Asp Met Ala Ala Asp Gly
             245                 250                 255

 cag cag ttc ggc gag ata aag gcc agc tca gcc gtg ctg tgc ctc tcc      872
 Gln Gln Phe Gly Glu Ile Lys Ala Ser Ser Ala Val Leu Cys Leu Ser
         260                 265                 270

 tac ctg cct gac atc ctg gtg act ggc acc tat gac aag aag gtg acc      920
 Tyr Leu Pro Asp Ile Leu Val Thr Gly Thr Tyr Asp Lys Lys Val Thr
     275                 280                 285

 atc tac gac ccc aga gcc ggc cca gcc ctg ttg aag cac cag caa cta      968
 Ile Tyr Asp Pro Arg Ala Gly Pro Ala Leu Leu Lys His Gln Gln Leu
 290                 295                 300                 305

 cac tcc aga ccc gtg ctg acc ctg ctg gcg gat gac cgg cac atc atc     1016
 His Ser Arg Pro Val Leu Thr Leu Leu Ala Asp Asp Arg His Ile Ile
                 310                 315                 320

 tca ggc agc gag gac cac acc ctg gtg gtg gtg gac cgc cga gcc aac     1064
 Ser Gly Ser Glu Asp His Thr Leu Val Val Val Asp Arg Arg Ala Asn
             325                 330                 335

 agc gtc ctg cag cgt ctg cag ctg gac tcc tac ctg ctc tgc atg tcc     1112
 Ser Val Leu Gln Arg Leu Gln Leu Asp Ser Tyr Leu Leu Cys Met Ser
         340                 345                 350

 tac cag gaa ccc cag ctc tgg gct ggt gac aac cag ggc ctg ctg cac     1160
 Tyr Gln Glu Pro Gln Leu Trp Ala Gly Asp Asn Gln Gly Leu Leu His
     355                 360                 365

 gtc ttc gcc aac cgc aac ggc tgc ttc cag ctt atc cgg tcc ttt gat     1208
 Val Phe Ala Asn Arg Asn Gly Cys Phe Gln Leu Ile Arg Ser Phe Asp
 370                 375                 380                 385

 gtg ggc cac agc ttt ccc atc act ggg atc cag tac tcc gtg gga gcc     1256
 Val Gly His Ser Phe Pro Ile Thr Gly Ile Gln Tyr Ser Val Gly Ala
                 390                 395                 400

 ttg tac acc aca tcc act gac aag acc atc cgg gtg cac gtg ccc aca     1304
 Leu Tyr Thr Thr Ser Thr Asp Lys Thr Ile Arg Val His Val Pro Thr
             405                 410                 415

 gac cca cca agg acc att tgc acc cga agg cat gac aat ggg ctc aat     1352
 Asp Pro Pro Arg Thr Ile Cys Thr Arg Arg His Asp Asn Gly Leu Asn
         420                 425                 430

 agg gtc tgt gct gag ggc aac ctg gtg gtg gcc ggc tct gga gac ctg     1400
 Arg Val Cys Ala Glu Gly Asn Leu Val Val Ala Gly Ser Gly Asp Leu
     435                 440                 445

 tcg cta gag gtc tgg agg ctg cag gcc tga g caggtgggcg tggatgtgga     1451
 Ser Leu Glu Val Trp Arg Leu Gln Ala 
 450                 455

 tactgcctgc cggaggctgg gc                                            1473




      <210> 136
      <211> 1252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(475)

      <400> 136
 ccaactcagc agcaaggtgg attttctttg tgtttaaaga aaaaaaatgt ccctgtgtct     60

 gtagagatga tttgcagttc agcccggctg aagctgaccg aatgagact    atg ggc     115
                                                          Met Gly
                                                            1

 tgt gcc tcc gcc aag cat gtt gcc act gtt caa aat gaa gag gaa gcc      163
 Cys Ala Ser Ala Lys His Val Ala Thr Val Gln Asn Glu Glu Glu Ala
           5                  10                  15

 cag aaa ggg aaa aac tac cag aac gga gat gtg ttt ggc gat gag tat      211
 Gln Lys Gly Lys Asn Tyr Gln Asn Gly Asp Val Phe Gly Asp Glu Tyr
      20                  25                  30

 agg atc aaa cca gtg gaa gag gtc aaa tac atg aaa aat ggg gca gaa      259
 Arg Ile Lys Pro Val Glu Glu Val Lys Tyr Met Lys Asn Gly Ala Glu
  35                  40                  45                  50

 gaa gag cag aaa ata gca gcc agg aac caa gaa aac ttg gaa aaa agt      307
 Glu Glu Gln Lys Ile Ala Ala Arg Asn Gln Glu Asn Leu Glu Lys Ser
                  55                  60                  65

 gcc agc tca aat gta aga ctt aaa act aat aaa gag gtt ccg gga tta      355
 Ala Ser Ser Asn Val Arg Leu Lys Thr Asn Lys Glu Val Pro Gly Leu
              70                  75                  80

 gtt cat caa ccc aga gca aac atg cac atc tct gaa agc caa caa gaa      403
 Val His Gln Pro Arg Ala Asn Met His Ile Ser Glu Ser Gln Gln Glu
          85                  90                  95

 ttc ttc aga atg ctg gat gaa aaa att gaa aag ggt cgg gat tac tgt      451
 Phe Phe Arg Met Leu Asp Glu Lys Ile Glu Lys Gly Arg Asp Tyr Cys
     100                 105                 110

 tcg gaa gaa gag gat atc aca tag caccaatttt accactcaaa ccaggagcta     505
 Ser Glu Glu Glu Asp Ile Thr 
 115                 120

 ctactgtgta aataggttac accccagttg aaatctttgc aaaggtcggt tctattcagc    565

 gaacagcact atagcaaaag aagatcgttc catattgtac gccccattaa attacagtgt    625

 ttcttaatga acttgcaaag gaatattgct aaaaacaaac aaaaaaaact gttatcgaac    685

 tttctttgtt gctgctagtt aaaacttgtt gcaacttttc acttctcttg tgtccaggta    745

 tgcagcaaaa ttctgcaatt tcaccttaaa gatactgttg gttttacaga tgctctccaa    805

 cctattttct ataagatgag gtagtggtga actcagataa caaacttctc ttctaaactg    865

 gttctgcttc taagacaagc atctcctgcc ctctctcctt cctccccatc tctcgcacgc    925

 agtctagaga tggactgagc cttgcttctc actggcagtg ttgagctttg gagatgggat    985

 ggttgctatg ccaagccttg tttctctgct cagaagaagt agagaagcta ttatcaatta   1045

 aaagcatgct gtgatgtgac tcctggaagt gacgtaggag tgagtggcag gttgtttgat   1105

 ttaataggta tcttaatcaa gaattaagct tgcaacattg gctttgctca gatgcagatg   1165

 gaagtgtgat cacaatcatt ttgaatccct cttcctcact tttttttcta agaaaataaa   1225

 cattttactg tttttaaaaa aaaaaaa                                       1252




      <210> 137
      <211> 2491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (495)..(1808)

      <400> 137
 ttcccccgtc cgcgcttctc agccgccagt ctcctggccg cgcagtcccc gcggacggcc     60

 gggccgcgag accctcgcag aagaggcgct gcgccggcga ggactggccg gcggatccga    120

 ggcgcgcgcc ccaccgccac ccccacccgc ctgccagccg gtccctccgg ccgccgccat    180

 gtcctcctcc tcttcctgcc ccagagtaga cgtacgagga ggaccgggag tacgagagcc    240

 aggccaagcg tctcaagacc gaggaggggg agatcgacta ctcggccgag gaaggcgaga    300

 accgccggga agcgacgccc cggggcgggg gcgatggcgg cggcggcggc cggagcttct    360

 ctcagccgga ggcaggtgga agtcatcata aagtttctgt ttcacccgtc gtccatgttc    420

 gaggactctg tgaatctgtg gtggaagcag acctcgtgga agcgctggaa aaatttggga    480

 caatatgcta tgtg  atg atg atg cca ttt aaa cga cag gct cta gtg gaa     530
                  Met Met Met Pro Phe Lys Arg Gln Ala Leu Val Glu
                    1               5                  10

 ttt gaa aac ata gat agt gcc aaa gaa tgt gtg aca ttt gct gca gat      578
 Phe Glu Asn Ile Asp Ser Ala Lys Glu Cys Val Thr Phe Ala Ala Asp
          15                  20                  25

 gaa ccc gtg tac att gct ggt caa cag gct ttt ttc aac tat tct aca      626
 Glu Pro Val Tyr Ile Ala Gly Gln Gln Ala Phe Phe Asn Tyr Ser Thr
      30                  35                  40

 agc aaa agg atc act cgg cca gga aat act gat gat cca tca gga ggc      674
 Ser Lys Arg Ile Thr Arg Pro Gly Asn Thr Asp Asp Pro Ser Gly Gly
  45                  50                  55                  60

 aac aaa gtt ctt ctg ctc tca att cag aat ccg ctt tat cca att aca      722
 Asn Lys Val Leu Leu Leu Ser Ile Gln Asn Pro Leu Tyr Pro Ile Thr
                  65                  70                  75

 gtg gat gtt tta tat act gta tgc aac cct gtt ggc aaa gtg caa cgt      770
 Val Asp Val Leu Tyr Thr Val Cys Asn Pro Val Gly Lys Val Gln Arg
              80                  85                  90

 att gtt ata ttc aag aga aat ggg ata caa gca atg gtt gag ttt gaa      818
 Ile Val Ile Phe Lys Arg Asn Gly Ile Gln Ala Met Val Glu Phe Glu
          95                 100                 105

 tca gtc ctt tgt gcc cag aaa gct aaa gca gca ctc aat gga gct gat      866
 Ser Val Leu Cys Ala Gln Lys Ala Lys Ala Ala Leu Asn Gly Ala Asp
     110                 115                 120

 ata tat gct gga tgt tgc aca cta aaa att gaa tat gca cgg cca act      914
 Ile Tyr Ala Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Arg Pro Thr
 125                 130                 135                 140

 cgt cta aat gtt att agg aat gac aat gac agt tgg gac tac act aaa      962
 Arg Leu Asn Val Ile Arg Asn Asp Asn Asp Ser Trp Asp Tyr Thr Lys
                 145                 150                 155

 cca tat ttg gga aga cga gat aga gga aag ggt cgc cag aga caa gcc     1010
 Pro Tyr Leu Gly Arg Arg Asp Arg Gly Lys Gly Arg Gln Arg Gln Ala
             160                 165                 170

 att ttg gga gaa cac cct tct tcg ttt aga cat gat ggc tat gga tcc     1058
 Ile Leu Gly Glu His Pro Ser Ser Phe Arg His Asp Gly Tyr Gly Ser
         175                 180                 185

 cat ggt cca tta ttg cct tta cca agt cgt tac aga atg ggc tct cga     1106
 His Gly Pro Leu Leu Pro Leu Pro Ser Arg Tyr Arg Met Gly Ser Arg
     190                 195                 200

 gat aca cct gaa ctt gtt gct tat cca tta cca cag gct tct tcc tct     1154
 Asp Thr Pro Glu Leu Val Ala Tyr Pro Leu Pro Gln Ala Ser Ser Ser
 205                 210                 215                 220

 tac atg cat gga gga aat ccc tct ggt tca gtt gta atg gtt agt gga     1202
 Tyr Met His Gly Gly Asn Pro Ser Gly Ser Val Val Met Val Ser Gly
                 225                 230                 235

 tta cat caa cta aaa atg aat tgt tca aga gtc ttc aac ctg ttc tgc     1250
 Leu His Gln Leu Lys Met Asn Cys Ser Arg Val Phe Asn Leu Phe Cys
             240                 245                 250

 tta tat gga aat att gag aag gta aaa ttt atg aag acc att cct ggt     1298
 Leu Tyr Gly Asn Ile Glu Lys Val Lys Phe Met Lys Thr Ile Pro Gly
         255                 260                 265

 aca gca ctg gta gaa atg ggt gat gag tat gct gta gaa aga gct gtc     1346
 Thr Ala Leu Val Glu Met Gly Asp Glu Tyr Ala Val Glu Arg Ala Val
     270                 275                 280

 aca cac ctt aat aat gtc aaa tta ttt ggg aaa aga ctt aat gtt tgc     1394
 Thr His Leu Asn Asn Val Lys Leu Phe Gly Lys Arg Leu Asn Val Cys
 285                 290                 295                 300

 gtg tct aaa caa cat tca gtt gtt cca agt caa ata ttt gag ctg gag     1442
 Val Ser Lys Gln His Ser Val Val Pro Ser Gln Ile Phe Glu Leu Glu
                 305                 310                 315

 gat ggt acc agc agc tac aaa gat ttt gca atg agc aaa aat aat cgc     1490
 Asp Gly Thr Ser Ser Tyr Lys Asp Phe Ala Met Ser Lys Asn Asn Arg
             320                 325                 330

 ttt aca agt gct ggc caa gca tct aag aat ata atc cag cca ccc tcc     1538
 Phe Thr Ser Ala Gly Gln Ala Ser Lys Asn Ile Ile Gln Pro Pro Ser
         335                 340                 345

 tgt gtt ttg cat tat tat aat gtt cca ttg tgt gtc aca gaa gag acc     1586
 Cys Val Leu His Tyr Tyr Asn Val Pro Leu Cys Val Thr Glu Glu Thr
     350                 355                 360

 ttc aca aag ttg tgt aat gac cat gaa gtt ctt aca ttc atc aaa tat     1634
 Phe Thr Lys Leu Cys Asn Asp His Glu Val Leu Thr Phe Ile Lys Tyr
 365                 370                 375                 380

 aaa gtg ttt gat gca aaa cct tca gcc aaa aca ctt tct ggg cta tta     1682
 Lys Val Phe Asp Ala Lys Pro Ser Ala Lys Thr Leu Ser Gly Leu Leu
                 385                 390                 395

 gaa tgg gag tgc aaa act gat gca gta gaa gcc ctt acg gca ctg aat     1730
 Glu Trp Glu Cys Lys Thr Asp Ala Val Glu Ala Leu Thr Ala Leu Asn
             400                 405                 410

 cac tat cag ata aga gtg ccg aat ggt tcc aat ccc tat aca ttg aag     1778
 His Tyr Gln Ile Arg Val Pro Asn Gly Ser Asn Pro Tyr Thr Leu Lys
         415                 420                 425

 ctt tgc ttt tct aca tca tcc cat tta taa g aagagaagag catgttagaa     1829
 Leu Cys Phe Ser Thr Ser Ser His Leu 
     430                 435

 tttatgttca cctttattac aatttcaaag ctacacttca ttaaaaaaaa atctaaaatg   1889

 gttgatctca tgttgccttg cttactttaa gatcctgttc tgtaataaac atattttgcc   1949

 ttgagtaaat ttgttgtaag cttaaatatt gaattgtttt cattttaaga tagaatatca   2009

 taatgtagac tatctacagc ttcattgtag attatacaga tatatgattt ctaaccttat   2069

 tactggaatt tttcttccac agtaaaaata tatttgcatt cttaatgcta attatctgca   2129

 agtatttttt cattgtgtaa gagattaatg caggtgaaag tattgcattt taatatagaa   2189

 ttcctattat atgtttagat gtttaagtat gttgcagtta ctcatattaa acataacttg   2249

 tatatttatt attttaatga agtttgagaa taacgttaca tatgttgaat tttaagtact   2309

 acagatttaa ctgattttat atttctgaaa ggctaacaga catggataca cgtgtacagt   2369

 atgcattcaa acttatttaa attggtgtat ttttttttaa gtcactgtcc atttgtattg   2429

 acatgcctct gtttctagtc cagtttggag attttataaa gttataacaa tgaaaaaaaa   2489

 aa                                                                  2491




      <210> 138
      <211> 507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(453)

      <400> 138
 aaggatcctt aattaattaa tccccccccc ccgagtcgga gccagcgcga gccgccgccg     60

 ccatcactgc cgctgccaag tcctccaccc gctgcccccg cc   atg tct gct acc     114
                                                  Met Ser Ala Thr
                                                    1

 gct gcc acg gcc ccc cct gct gcc ccg gct ggg gag ggt ggt ccc cct      162
 Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu Gly Gly Pro Pro
   5                  10                  15                  20

 gca ccc cct cca aac ctc acc agt aac agg aga ctg cag cag acc cag      210
 Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln
                  25                  30                  35

 gcc cag gtg gat gag gtg gtg gac atc atg agg gtg aac gtg gac aag      258
 Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys
              40                  45                  50

 gtc ctg gag cga gac cag aag ctg tcg gag ctg gac gac cgt gca gat      306
 Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp
          55                  60                  65

 gca ctc cag gcg ggg gcc tcc cag ttt gaa aca agc gca gcc aag ctc      354
 Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu
      70                  75                  80

 aag cgc aaa tac tgg tgg aaa aac ctc aag atg atg atc atc ttg gga      402
 Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met Ile Ile Leu Gly
  85                  90                  95                 100

 gtg att tgc gcc atc atc ctc atc atc atc ata gtt tac ttc agc act      450
 Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val Tyr Phe Ser Thr
                 105                 110                 115

 taa atcc ccgaggagtc tgccctgcct agagaagggc ctctccccca accctcagcc      507
 






      <210> 139
      <211> 4098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(1522)

      <400> 139
 cctccggatt cccgggtcga cttcgctgtc gacgatttcg taaactgtat ctgaagaaaa     60

 caaaagcctt atctggacac tattgaaaca agtccgtcct ggc  atg gac cta tcc     115
                                                  Met Asp Leu Ser
                                                    1

 aag gtg gtt ctg cct aca ttt att ttg gaa ccc cgt tct ttc ctg gat      163
 Lys Val Val Leu Pro Thr Phe Ile Leu Glu Pro Arg Ser Phe Leu Asp
   5                  10                  15                  20

 aaa ctt tca gat tac tac tat cat gca gat ttc cta tct gag gca gct      211
 Lys Leu Ser Asp Tyr Tyr Tyr His Ala Asp Phe Leu Ser Glu Ala Ala
                  25                  30                  35

 ctt gaa gaa aat cct tat ttc cgt ttg aag aaa gta gtg aaa tgg tat      259
 Leu Glu Glu Asn Pro Tyr Phe Arg Leu Lys Lys Val Val Lys Trp Tyr
              40                  45                  50

 ttg tca gga ttc tat aaa aag cca aag gga ctg aag aaa cct tat aat      307
 Leu Ser Gly Phe Tyr Lys Lys Pro Lys Gly Leu Lys Lys Pro Tyr Asn
          55                  60                  65

 cct ata ctt ggc gag act ttc cgt tgt tta tgg att cat ccc aga aca      355
 Pro Ile Leu Gly Glu Thr Phe Arg Cys Leu Trp Ile His Pro Arg Thr
      70                  75                  80

 aac agc aaa act ttt tat att gct gaa cag gtg tcc cat cat cca cca      403
 Asn Ser Lys Thr Phe Tyr Ile Ala Glu Gln Val Ser His His Pro Pro
  85                  90                  95                 100

 ata tct gcc ttt tat gtt agt aat cga aaa gat gga ttt tgc ctt agc      451
 Ile Ser Ala Phe Tyr Val Ser Asn Arg Lys Asp Gly Phe Cys Leu Ser
                 105                 110                 115

 ggt agt atc ctg gct aag tct aag ttt tat gga aac tca tta tct gca      499
 Gly Ser Ile Leu Ala Lys Ser Lys Phe Tyr Gly Asn Ser Leu Ser Ala
             120                 125                 130

 ata tta gag gga gaa gca cgg tta act ttc ttg aat aga ggt gaa gat      547
 Ile Leu Glu Gly Glu Ala Arg Leu Thr Phe Leu Asn Arg Gly Glu Asp
         135                 140                 145

 tat gta atg aca atg cca tac gct cat tgt aaa gga att ctt tat ggt      595
 Tyr Val Met Thr Met Pro Tyr Ala His Cys Lys Gly Ile Leu Tyr Gly
     150                 155                 160

 aca atg aca ctg gag ctt ggt gga aca gtc aat att aca tgt caa aaa      643
 Thr Met Thr Leu Glu Leu Gly Gly Thr Val Asn Ile Thr Cys Gln Lys
 165                 170                 175                 180

 act gga tac agt gca ata ctt gaa ttt aaa cta aag cca ttc cta ggg      691
 Thr Gly Tyr Ser Ala Ile Leu Glu Phe Lys Leu Lys Pro Phe Leu Gly
                 185                 190                 195

 agt agt gac tgt gtt aat caa ata tca ggg aaa ctt aaa ctg gga aaa      739
 Ser Ser Asp Cys Val Asn Gln Ile Ser Gly Lys Leu Lys Leu Gly Lys
             200                 205                 210

 gaa gtc cta gct act ttg gaa ggt cat tgg gat agt gaa gtt ttt att      787
 Glu Val Leu Ala Thr Leu Glu Gly His Trp Asp Ser Glu Val Phe Ile
         215                 220                 225

 act gat aaa aag act gat aat tca gag gtt ttc tgg aat cca aca cct      835
 Thr Asp Lys Lys Thr Asp Asn Ser Glu Val Phe Trp Asn Pro Thr Pro
     230                 235                 240

 gac att aag caa tgg aga tta ata agg cac act gta aaa ttt gaa gaa      883
 Asp Ile Lys Gln Trp Arg Leu Ile Arg His Thr Val Lys Phe Glu Glu
 245                 250                 255                 260

 cag gga gat ttt gaa tca gag aaa ctc tgg caa cgg gta act cga gcc      931
 Gln Gly Asp Phe Glu Ser Glu Lys Leu Trp Gln Arg Val Thr Arg Ala
                 265                 270                 275

 ata aat gcc aaa gac caa act gaa gct acc caa gag aag tat gtt ttg      979
 Ile Asn Ala Lys Asp Gln Thr Glu Ala Thr Gln Glu Lys Tyr Val Leu
             280                 285                 290

 gaa gaa gct caa aga caa gct gcc agg gat cgg aaa aca aaa aat gaa     1027
 Glu Glu Ala Gln Arg Gln Ala Ala Arg Asp Arg Lys Thr Lys Asn Glu
         295                 300                 305

 gag tgg tct tgc aaa tta ttt gaa ctt gat cca ctc aca gga gaa tgg     1075
 Glu Trp Ser Cys Lys Leu Phe Glu Leu Asp Pro Leu Thr Gly Glu Trp
     310                 315                 320

 cat tac aag ttt gca gat acc cga cca tgg gac cca ctt aat gat atg     1123
 His Tyr Lys Phe Ala Asp Thr Arg Pro Trp Asp Pro Leu Asn Asp Met
 325                 330                 335                 340

 ata cag ttt gaa aaa gat ggt gtt att cag acc aaa gtg aaa cat cgt     1171
 Ile Gln Phe Glu Lys Asp Gly Val Ile Gln Thr Lys Val Lys His Arg
                 345                 350                 355

 act cca atg gtt agc gtc ccc aaa atg aaa cat aag cca acc agg caa     1219
 Thr Pro Met Val Ser Val Pro Lys Met Lys His Lys Pro Thr Arg Gln
             360                 365                 370

 cag aag aaa gta gca aaa ggc tat tcc tcc cca gaa cct gac att caa     1267
 Gln Lys Lys Val Ala Lys Gly Tyr Ser Ser Pro Glu Pro Asp Ile Gln
         375                 380                 385

 gac tcc tct gga agt gaa gct caa tca gta aaa cca agt aca aga aga     1315
 Asp Ser Ser Gly Ser Glu Ala Gln Ser Val Lys Pro Ser Thr Arg Arg
     390                 395                 400

 aag aaa gga ata gaa ctg gga gac att cag agt tcc atc gaa tct ata     1363
 Lys Lys Gly Ile Glu Leu Gly Asp Ile Gln Ser Ser Ile Glu Ser Ile
 405                 410                 415                 420

 aaa caa aca cag gaa gaa aaa aaa aaa aat att atg gct ctt cga aat     1411
 Lys Gln Thr Gln Glu Glu Lys Lys Lys Asn Ile Met Ala Leu Arg Asn
                 425                 430                 435

 cat tta gtt tca agc aca ccg gcc acg gat tat ttt ctg caa caa aaa     1459
 His Leu Val Ser Ser Thr Pro Ala Thr Asp Tyr Phe Leu Gln Gln Lys
             440                 445                 450

 gac tac ttc atc att ttc ctc ctg att ttg ctt caa gtc ata ata aac     1507
 Asp Tyr Phe Ile Ile Phe Leu Leu Ile Leu Leu Gln Val Ile Ile Asn
         455                 460                 465

 ttc atg ttc aag tag aagttctcta ccattgaatc agtgaactag aaagatctga     1562
 Phe Met Phe Lys 
     470

 tttggcctgg gaccagtgtt caagttggtt tggtctttat taaaaatcac aatattccga   1622

 aaacaaaaaa acctaggaga taaatgtaga ggtattgact tttcgtatct tttatcttca   1682

 cactgaaaca agagctatcc tatttgatta ttaaagtgag ctatgtgtta agtgccagga   1742

 catttctagc ttttgtgaga atgtgtctac atatgagtat aataaaccca catgtataca   1802

 caattgtctc ttatgtactc ctacctgaca gtagtctttg tattctatag tatgttctga   1862

 gatataatgt taacattgtt cataacaaaa aatgctatca atcttataaa tatatgtaat   1922

 ctattttctt cataaaacag gcacaaaagt tttatcagta aggaattaca gattgagaaa   1982

 tgatggaata atagacataa ttaattcaat acactactgt taaaatcatt tgcaaagcac   2042

 tcagctcaat tatcttctta gaaagaaaga aaaagtatga atggtcaaaa tgaatacatc   2102

 gagagagata aatggcaaat tgctttttta aaagtttaca taagtttttt ttaaccccta   2162

 gaatttaata tttgtagatg caggtaaata tatatactta cgtgtatttc aagtattaaa   2222

 aacactggtg tgcaattaat tggattgatt ataataccac cttaagcact tgcttgaaaa   2282

 aagtgtggtc aaaattgcat tgctgtcctt ttgtcttatt tttgtttttc ttaagtcagc   2342

 tggttcataa cataggccaa attctagaga tgtttataga gcatttgaag tgctgataat   2402

 ttatgttttt tcattatgaa aacttatttt agctttagac tccagtgtgt tcagtgaata   2462

 agtagaatat aaaaaaatat aaccagtatt ttacttcaaa agccaaaaag aggcaataag   2522

 aaaagacact ttgtggtggc ctttatgtgt gcattaaaat tggtttctgt aaaacgtgta   2582

 ataagttgag tatctacgaa gagtatcaag ttctgaagtt taattttttt attatcctcc   2642

 tctcttctta gtaacttctt tctgtggcaa aaccacaatt ctttaagatt cctattgttc   2702

 aggctaaggc aaattttttt gtttgtttct tcagtttaat attttgattt tgtgttttta   2762

 cgtaaatatt tatattcctt gaaagcaatt tttgccaagg tagttcagtt taggaatatg   2822

 ttgttctaaa atatgtctta gaatcctgaa agcatagatt ttgaaatgtt tttttaatga   2882

 aaatgaaggt cagagagaat aattgccctg accacatttg cctttcagta ggaggaggct   2942

 gtgaaatagt aaaattataa tcgtttatgc catgataaat acaagattgg taaataaata   3002

 cattgattgg taaattatga gaatcaaaat gataaaaaga gcctgctttt ttccctaacc   3062

 aatatagcta tcttaagtat ccttaggttt ctgtgaagaa ccatttccca tgttttcttg   3122

 gcaaaataat gctgtattcc atatgtacat gtgaaatgat gttttaaatt gataaaagct   3182

 taaataagat ctacctatac ccagtatttt catgatatta gaacaaatgg gtttttggtt   3242

 atattttata tttgtcaata taatttttgt attcacattc tgttacactc tgcctattca   3302

 ttgatataat gatattctgt aaatattgta caatttgatc ttttttatgg tttaaattag   3362

 ttaattacat acaaattgat tggcttatca caaaaatcat ttcatcagta aaccttgtta   3422

 acattttgta ctggtgaccc acctcttagg actttggtct tatccacgtg tatgttgttt   3482

 tcatttggtc caaataatat tttatttgta tgggtatctt ctaagactaa ataggtagtt   3542

 gtgttcttta tttttaaaat ttctttttag agcaaatgtt atgggttctt acccaaagag   3602

 tcaaaaacta tttcttaaga aagagcagag ttattcatga ctgttcttta tacactaaaa   3662

 gcatgcatct aatctaatag tcctcttatt atgcttttag ttgtatgagt ctctttctat   3722

 gaactgaaca caaaactcag gaattggtgg cttaatttta gatcagtgct tgtactaggc   3782

 ttagttatat gaatctttat aacacataat tactaacttt gtagccatat atgtaattga   3842

 ctttgaatgt tatttacctg aaattaatct tccttcacac atggaccgta aacggttccc   3902

 agttgtctga gagcctcatg agggtttcta ggatttatga ccttatgacc agtttttttc   3962

 atttaccaag attttatttt cctacatgaa aatttaattg agtaataatt attcacatgt   4022

 gcattttctt tttagctgtt aaatgtacta tgccatcatc caccatttag taaaatgtag   4082

 ctggcccagg acatgt                                                   4098




      <210> 140
      <211> 2032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(1519)

      <400> 140
 tggcgaattc ggcacgaggg gcggcgccgc agtcccgcga gcc  atg gcc cag tcc      55
                                                  Met Ala Gln Ser
                                                    1

 ggc ggt gag gct cgg ccc ggg ccc aag acg gcg gtg cag atc cgc gtc      103
 Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala Val Gln Ile Arg Val
   5                  10                  15                  20

 gcc atc cag gag gcc gag gac gtg gac gag ttg gag gac gag gag gag      151
 Ala Ile Gln Glu Ala Glu Asp Val Asp Glu Leu Glu Asp Glu Glu Glu
                  25                  30                  35

 ggg gcg gag act cgg ggc gcc ggg gac ccg gcc cgg tac ctc agc ccc      199
 Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala Arg Tyr Leu Ser Pro
              40                  45                  50

 ggc tgg ggc agc gcg agc gag gag gag ccg agc cgc ggg cac agt ggc      247
 Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser Arg Gly His Ser Gly
          55                  60                  65

 acc act gca agt gga ggt gag aac gag cgt gag gac ctg gag cag gag      295
 Thr Thr Ala Ser Gly Gly Glu Asn Glu Arg Glu Asp Leu Glu Gln Glu
      70                  75                  80

 tgg aag ccc ccg gat gag gag ttg atc aag aaa ctg gtg gat cag atc      343
 Trp Lys Pro Pro Asp Glu Glu Leu Ile Lys Lys Leu Val Asp Gln Ile
  85                  90                  95                 100

 gaa ttc tac ttt tct gat gaa aac ctg gag aag gac gcc ttt ttg cta      391
 Glu Phe Tyr Phe Ser Asp Glu Asn Leu Glu Lys Asp Ala Phe Leu Leu
                 105                 110                 115

 aaa cac gtg agg agg aac aag ctg gga tat gtg agc gtt aag cta ctc      439
 Lys His Val Arg Arg Asn Lys Leu Gly Tyr Val Ser Val Lys Leu Leu
             120                 125                 130

 aca tcc ttc aaa aag gtg aaa cat ctt aca cgg gac tgg aga acc aca      487
 Thr Ser Phe Lys Lys Val Lys His Leu Thr Arg Asp Trp Arg Thr Thr
         135                 140                 145

 gca cat gct ttg aag tat tca gtg gtc ctt gag ttg aat gag gac cac      535
 Ala His Ala Leu Lys Tyr Ser Val Val Leu Glu Leu Asn Glu Asp His
     150                 155                 160

 cgg aag gtg agg agg acc acc ccc gtc cca ctg ttc ccc aac gag aac      583
 Arg Lys Val Arg Arg Thr Thr Pro Val Pro Leu Phe Pro Asn Glu Asn
 165                 170                 175                 180

 ctc ccc agc aag atg ctc ctg gtc tat gat ctc tac ttg tct cct aag      631
 Leu Pro Ser Lys Met Leu Leu Val Tyr Asp Leu Tyr Leu Ser Pro Lys
                 185                 190                 195

 ctg tgg gct ctg gcc acc ccc cag aag aat gga agg gtg caa gag aag      679
 Leu Trp Ala Leu Ala Thr Pro Gln Lys Asn Gly Arg Val Gln Glu Lys
             200                 205                 210

 gtg atg gaa cac ctg ctc aag ctt ttt ggg act ttt gga gtc atc tca      727
 Val Met Glu His Leu Leu Lys Leu Phe Gly Thr Phe Gly Val Ile Ser
         215                 220                 225

 tca gtg cgg atc ctc aaa cct ggg aga gag ctg ccc cct gac atc cgg      775
 Ser Val Arg Ile Leu Lys Pro Gly Arg Glu Leu Pro Pro Asp Ile Arg
     230                 235                 240

 agg atc agc agc cgc tac agc caa gtg ggg acc cag gag tgc gcc atc      823
 Arg Ile Ser Ser Arg Tyr Ser Gln Val Gly Thr Gln Glu Cys Ala Ile
 245                 250                 255                 260

 gtg gag ttc gag gag gtg gaa gca gcc atc aaa gcc cat gag ttc atg      871
 Val Glu Phe Glu Glu Val Glu Ala Ala Ile Lys Ala His Glu Phe Met
                 265                 270                 275

 atc aca gaa tct cag ggc aaa gag aac atg aaa gct gtc ctg att ggt      919
 Ile Thr Glu Ser Gln Gly Lys Glu Asn Met Lys Ala Val Leu Ile Gly
             280                 285                 290

 atg aag cca ccc aaa aag aaa cct gcc aaa gac aaa aat cat gac gag      967
 Met Lys Pro Pro Lys Lys Lys Pro Ala Lys Asp Lys Asn His Asp Glu
         295                 300                 305

 gag ccc act gcg agc atc cac ctg aac aag tcc ctg aac aag aga gtc     1015
 Glu Pro Thr Ala Ser Ile His Leu Asn Lys Ser Leu Asn Lys Arg Val
     310                 315                 320

 gag gag ctt cag tac atg ggt gat gag tct tct gcc aac agc tcc tct     1063
 Glu Glu Leu Gln Tyr Met Gly Asp Glu Ser Ser Ala Asn Ser Ser Ser
 325                 330                 335                 340

 gac ccc gag agc aac ccc aca tcc cct atg gcg ggc cga cgg cac gcg     1111
 Asp Pro Glu Ser Asn Pro Thr Ser Pro Met Ala Gly Arg Arg His Ala
                 345                 350                 355

 gcc acc aac aag ctc agc ccg tct ggc cac cag aat ctc ttt ctg agt     1159
 Ala Thr Asn Lys Leu Ser Pro Ser Gly His Gln Asn Leu Phe Leu Ser
             360                 365                 370

 cca aat gcc tcc ccg tgc aca agt cct tgg agc agc ccc ttg gcc caa     1207
 Pro Asn Ala Ser Pro Cys Thr Ser Pro Trp Ser Ser Pro Leu Ala Gln
         375                 380                 385

 cgc aaa ggc gtt tcc aga aag tcc cca ctg gcg gag gaa ggt aga ctg     1255
 Arg Lys Gly Val Ser Arg Lys Ser Pro Leu Ala Glu Glu Gly Arg Leu
     390                 395                 400

 aac tgc agc acc agc cct gag atc ttc cgc aag tgt atg gat tat tcc     1303
 Asn Cys Ser Thr Ser Pro Glu Ile Phe Arg Lys Cys Met Asp Tyr Ser
 405                 410                 415                 420

 tct gac agc agc gtc act ccc tct ggc agc ccc tgg gtc cgg agg cgt     1351
 Ser Asp Ser Ser Val Thr Pro Ser Gly Ser Pro Trp Val Arg Arg Arg
                 425                 430                 435

 cgc caa gcc gag atg ggg acc cag gag aaa agc ccc ggt acg agt ccc     1399
 Arg Gln Ala Glu Met Gly Thr Gln Glu Lys Ser Pro Gly Thr Ser Pro
             440                 445                 450

 ctg ctc tcc cgg aag atg cag act gca gat ggg cta ccc gta ggg gtg     1447
 Leu Leu Ser Arg Lys Met Gln Thr Ala Asp Gly Leu Pro Val Gly Val
         455                 460                 465

 ctg agg ttg ccc agg ggt cct gac aac acc aga gga ttt cat ggc cat     1495
 Leu Arg Leu Pro Arg Gly Pro Asp Asn Thr Arg Gly Phe His Gly His
     470                 475                 480

 gag agg agc agg gcc tgt gta taa ataccttcta tttttaatac aagctccact    1549
 Glu Arg Ser Arg Ala Cys Val 
 485                 490

 gaaaaccacc ttcgttttca aggttctgac aaacacctgg catgacagaa tggaattcgt   1609

 tcccctttga gagatttttt attcatgtag acctcttaat ttatctatct gtaatataca   1669

 taaatcggta cgccatggtt tgaagaccac cttctagttc aggactcctg ttcttcccag   1729

 catggccact attttgatga tggctgatgt gtgtgagtgt gatggccctg aagggctgta   1789

 ggacggaggt tccctggggg aagtctgttc tttggtatgg aatttttctc tcttctttgg   1849

 tatggaattt ttcccttcag tgactgagct gtcctcgata ggccatgcaa gggcttcctg   1909

 agagttcagg aaagttctct tgtgcaacag caagtagcta agcctatagc atggtgtctt   1969

 gtaggaccaa atcgatgtta cctgtcaagt aaataaataa taaaacaccc aaaaaaaaaa   2029

 aaa                                                                 2032




      <210> 141
      <211> 1014
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(508)

      <400> 141
 gctgcgctca ggcccgtgga tctcatcgaa g   atg gcg gcg cga tct gtg tcg      52
                                      Met Ala Ala Arg Ser Val Ser
                                        1               5

 ggc att acc aga aga gtc ttc atg tgg aca gtc tca ggg aca cca tgt      100
 Gly Ile Thr Arg Arg Val Phe Met Trp Thr Val Ser Gly Thr Pro Cys
          10                  15                  20

 aga gaa ttt tgg tct cga ttc aga aaa gag aaa gag cca gtg gtt gtt      148
 Arg Glu Phe Trp Ser Arg Phe Arg Lys Glu Lys Glu Pro Val Val Val
      25                  30                  35

 gag aca gta gaa gag aaa aag gaa cct atc cta gtg tgt cca cct tta      196
 Glu Thr Val Glu Glu Lys Lys Glu Pro Ile Leu Val Cys Pro Pro Leu
  40                  45                  50                  55

 cga agc cga gca tac aca cca cct gaa gat ctc cag agt cgt ttg gaa      244
 Arg Ser Arg Ala Tyr Thr Pro Pro Glu Asp Leu Gln Ser Arg Leu Glu
                  60                  65                  70

 tct tac gtt aaa gaa gtt ttt ggt tca tct ctt cct agt aat tgg caa      292
 Ser Tyr Val Lys Glu Val Phe Gly Ser Ser Leu Pro Ser Asn Trp Gln
              75                  80                  85

 gac atc tcc ctg gaa gat agt cgt cta aag ttc aat ctt ctg gct cat      340
 Asp Ile Ser Leu Glu Asp Ser Arg Leu Lys Phe Asn Leu Leu Ala His
          90                  95                 100

 tta gct gat gac ttg ggt cat gta gtc cct aac tcc aga ctc cac cag      388
 Leu Ala Asp Asp Leu Gly His Val Val Pro Asn Ser Arg Leu His Gln
     105                 110                 115

 atg tgc agg gtt aga gat gtt ctt gat ttc tat aat gtc cct att caa      436
 Met Cys Arg Val Arg Asp Val Leu Asp Phe Tyr Asn Val Pro Ile Gln
 120                 125                 130                 135

 gat aga tct aaa ttt gat gaa ctc agt gcc agt aat ctg ccc ccc aat      484
 Asp Arg Ser Lys Phe Asp Glu Leu Ser Ala Ser Asn Leu Pro Pro Asn
                 140                 145                 150

 ttg aaa atc act tgg agt tac taa gcaattcgga agagaaacac attgaaatca     538
 Leu Lys Ile Thr Trp Ser Tyr 
             155

 ctgtctttcc ctgagcaagg gggctgctca ttagatcttt tgatacttta ccatgtgaaa    598

 tactaccaga actgttctct aaacccactt tttctgtaga ggaatgtatc atcttttttt    658

 ttctcatatt acaaatggac aaataacgga ctttctattt tcatatttgc tgaaaccatt    718

 ttttaaatga aattaggtca ttatttatga aaagttttga gagggcactg tcaacttggg    778

 tttaagacag gaggacattg caagttcaca cctttcataa gcataaagta gttgcaagaa    838

 agtattttca tcctgttagg attcatatct aagatagagt tatgcattgc acatacacaa    898

 ataaactttt attagataga tacctataaa agaaacataa aagtatgttg tgtattactg    958

 acagttctag attaatttct tttagaatta aagtagattt gttaaaaaaa aaaaaa       1014




      <210> 142
      <211> 1340
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (254)..(991)

      <400> 142
 gcctccgggt cgcggtcatt ttgagcccct gtctggatga cttcttgcgg ctgttctacc     60

 cctccccctc cccgcgtcgc ctgctgctgt cgtcgggagg tgggtgaggt gacgcaaaca    120

 gccccgttgt tgccctccgc gtatcccctc accacctttg cggccatcca cgactttcgc    180

 accttccgcc attttcctgc ctgtgagggt ggacagatcg cgctcgggtc tcggcctcct    240

 gagtgccgga aag   atg aat ggg agg gct gat ttt cga gag ccg aat gca     289
                  Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala
                    1               5                  10

 gag gtt cca aga cca att ccc cac ata ggg cct gat tac att cca aca      337
 Glu Val Pro Arg Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr
          15                  20                  25

 gag gaa gaa agg aga gtc ttc gca gaa tgc aat gat gaa agc ttc tgg      385
 Glu Glu Glu Arg Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp
      30                  35                  40

 ttc aga tct gtg cct ttg gct gca aca agt atg ttg att act caa gga      433
 Phe Arg Ser Val Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly
  45                  50                  55                  60

 tta att agt aaa gga ata ctt tca agt cat ccc aaa tat ggt tcc atc      481
 Leu Ile Ser Lys Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile
                  65                  70                  75

 cct aaa ctt ata ctt gct tgt atc atg gga tac ttt gct gga aaa ctt      529
 Pro Lys Leu Ile Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu
              80                  85                  90

 tct tat gtg aaa act tgc caa gag aaa ttc aag aaa ctt gaa aat tcc      577
 Ser Tyr Val Lys Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser
          95                 100                 105

 ccc ctt gga gaa gct tta cga tca gga caa gca cga cga tct tca cca      625
 Pro Leu Gly Glu Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro
     110                 115                 120

 cct ggg cac tat tat caa aag tca aaa tat gac tca agt gtg agt ggt      673
 Pro Gly His Tyr Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly
 125                 130                 135                 140

 caa tca tct ttt gtg aca tcc cca gca gca gac aac ata gaa atg ctt      721
 Gln Ser Ser Phe Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu
                 145                 150                 155

 cct cat tat gag cca att cca ttc agt tct tct atg aat gaa tct gct      769
 Pro His Tyr Glu Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala
             160                 165                 170

 ccc act ggt att act gat cat att gtc caa gga cct gat ccc aac ctt      817
 Pro Thr Gly Ile Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu
         175                 180                 185

 gaa gaa agt cct aaa aga aaa aat att aca tat gag gaa tta agg aat      865
 Glu Glu Ser Pro Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn
     190                 195                 200

 aag aac aga gag tca tat gaa gta tct tta aca caa aag act gac ccc      913
 Lys Asn Arg Glu Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro
 205                 210                 215                 220

 tca gtc agg cct atg cat gaa aga gtg cca aaa aaa gaa gtc aaa gta      961
 Ser Val Arg Pro Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val
                 225                 230                 235

 aac aag tat gga gat act tgg gat gag tga a aaattacatc attggacatg     1012
 Asn Lys Tyr Gly Asp Thr Trp Asp Glu 
             240                 245

 aaggagtttc aacatccagc ttcatctagg tggtcatgat tacctgcatg ctttgagctc   1072

 agcagcagtc ttcataaaca catttaaaac aagatcctgg gtttttgtgg tttgacttct   1132

 atggtgtttt aaagaaacac agatttttag gtgttaatat tgtgttaatg tactcacctt   1192

 agggattcat ttgaatgatg ggtttatacc atgattgtat acagtttgtg agattgttgc   1252

 cagggcaagt gtactcttta aaaccgtcgg ggttccgtgc tctggatccg catttaggta   1312

 ttaatgtatc tgctggacgt tggggagt                                      1340




      <210> 143
      <211> 1253
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (136)..(819)

      <400> 143
 tttcctgtcc tggaggaaga acggcacaga cggagggagg ctggggttgg cagagactgg     60

 gacggaagtc cctcagtccc ccaggattct cctttatgga cccggggatc ccaagagggg    120

 ctgcctcaac ttaag atg ggc aac tgt gtc aag tat cca ctg aga aat ctc     171
                  Met Gly Asn Cys Val Lys Tyr Pro Leu Arg Asn Leu
                    1               5                  10

 tca agg aag atg cgc cag gag gaa cag acc agc tac atg gtg gtg cag      219
 Ser Arg Lys Met Arg Gln Glu Glu Gln Thr Ser Tyr Met Val Val Gln
          15                  20                  25

 acg acc gag gag ggg ctg gcg gct gac gcc gag ctc ccg gga ccg ctc      267
 Thr Thr Glu Glu Gly Leu Ala Ala Asp Ala Glu Leu Pro Gly Pro Leu
      30                  35                  40

 ctg atg ctg gcc cag aac tgc gca gtc atg cac aac ctg ctg ggc cct      315
 Leu Met Leu Ala Gln Asn Cys Ala Val Met His Asn Leu Leu Gly Pro
  45                  50                  55                  60

 gcc tgc att ttc ctg cgc aag ggc ttc gct gag aac agg cag cct gat      363
 Ala Cys Ile Phe Leu Arg Lys Gly Phe Ala Glu Asn Arg Gln Pro Asp
                  65                  70                  75

 aga tca ctg cga cca gag gaa att gaa gag ctc cga gag gcc ttc aga      411
 Arg Ser Leu Arg Pro Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg
              80                  85                  90

 gaa ttc gac aag gac aag gat ggc tac atc aac tgc cgg gat ctg ggc      459
 Glu Phe Asp Lys Asp Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly
          95                 100                 105

 aac tgc atg cgc acc atg ggc tac atg ccc acc gag atg gag ctc atc      507
 Asn Cys Met Arg Thr Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile
     110                 115                 120

 gaa ctg tcc cag cag atc aac atg aac ctg ggt ggc cat gta gat ttt      555
 Glu Leu Ser Gln Gln Ile Asn Met Asn Leu Gly Gly His Val Asp Phe
 125                 130                 135                 140

 gat gac ttc gtg gag cta atg ggg cct aaa ctc ctg gca gag aca gca      603
 Asp Asp Phe Val Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala
                 145                 150                 155

 gat atg att ggt gta aag gaa ctg cga gat gct ttc cga gag ttt gac      651
 Asp Met Ile Gly Val Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp
             160                 165                 170

 acc aat ggt gat ggg gaa ata agc acc agt gag ctg cga gag gct atg      699
 Thr Asn Gly Asp Gly Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met
         175                 180                 185

 agg aag ctc ctg ggt cat cag gtg gga cac cga gac ata gag gaa att      747
 Arg Lys Leu Leu Gly His Gln Val Gly His Arg Asp Ile Glu Glu Ile
     190                 195                 200

 atc cga gat gtg gac ctc aat ggg gat gga cga gtg gac ttt gaa gag      795
 Ile Arg Asp Val Asp Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu
 205                 210                 215                 220

 ttt gtc cgg atg atg tcc cgc tga ggccgcgagg gcccctccag gactgccaag     849
 Phe Val Arg Met Met Ser Arg 
                 225

 ctcccaaagg cggggctaag aggagctaga gcttgcctca cccgctgtag ccgccgagag    909

 cccaggatgt actggcggat ggggcctgcc tgcaccccgg ggaggcgccc accccggacc    969

 cccacccctc cgcactgtga aagactaact cctgcaactg gaaagcgggg gcgcccgccg   1029

 acgaggaggc caccgtgcca agccggcaga ggtcatgcca ggcgccaagg gccatgtgcc   1089

 cagctgctgc tggctgggtg ggccagggag cccgccagca gaccccacac agcatgtccg   1149

 ccccagggca aagcctccca ccttcgctct gcgcccgtcc cagctcgcct cagccctgtt   1209

 atctcagaac caataaaaat atttccaaga gcaaaaaaaa aaaa                    1253




      <210> 144
      <211> 3020
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(2496)

      <400> 144
 gctgttacgc ctgcaggtac cggaccggaa ttcccgggtc gacgatttcg tccaggctct     60

 cctgcttctc cacggactct gcgggaagtt agagcctctg cgtgcgctcc ggggcccggc    120

 gagagg   atg cgc aag gtg gag agc cgc ggg gaa ggg ggc aga gag gaa     168
          Met Arg Lys Val Glu Ser Arg Gly Glu Gly Gly Arg Glu Glu
            1               5                  10

 ctg gga agt aac agc cct cca cag aga aac tgg aag gga att gct att      216
 Leu Gly Ser Asn Ser Pro Pro Gln Arg Asn Trp Lys Gly Ile Ala Ile
  15                  20                  25                  30

 gct ctg ctg gtg att tta gtt gta tgc tca ctc atc act atg tca gtc      264
 Ala Leu Leu Val Ile Leu Val Val Cys Ser Leu Ile Thr Met Ser Val
                  35                  40                  45

 atc ctc tta acc cca gat gaa ctc aca aat tcg tca gaa acc aga ttg      312
 Ile Leu Leu Thr Pro Asp Glu Leu Thr Asn Ser Ser Glu Thr Arg Leu
              50                  55                  60

 tct ttg gaa gac ctc ttt agg aaa gac ttt gtg ctt cac gat cca gag      360
 Ser Leu Glu Asp Leu Phe Arg Lys Asp Phe Val Leu His Asp Pro Glu
          65                  70                  75

 gct cgg tgg atc aat gat aca gat gtg gtg tat aaa agc gag aat gga      408
 Ala Arg Trp Ile Asn Asp Thr Asp Val Val Tyr Lys Ser Glu Asn Gly
      80                  85                  90

 cat gtc att aaa ctg aat ata gaa aca aat gct acc aca tta tta ttg      456
 His Val Ile Lys Leu Asn Ile Glu Thr Asn Ala Thr Thr Leu Leu Leu
  95                 100                 105                 110

 gaa aac aca act ttt gta acc ttc aaa gca tca aga cat tca gtt tca      504
 Glu Asn Thr Thr Phe Val Thr Phe Lys Ala Ser Arg His Ser Val Ser
                 115                 120                 125

 cca gat tta aaa tat gtc ctt ctg gca tat gat gtc aaa cag att ttt      552
 Pro Asp Leu Lys Tyr Val Leu Leu Ala Tyr Asp Val Lys Gln Ile Phe
             130                 135                 140

 cat tat tcg tat act gct tca tat gtg att tac aac ata cac act agg      600
 His Tyr Ser Tyr Thr Ala Ser Tyr Val Ile Tyr Asn Ile His Thr Arg
         145                 150                 155

 gaa gtt tgg gag tta aat cct cca gaa gta gag gac tcc gtc ttg cag      648
 Glu Val Trp Glu Leu Asn Pro Pro Glu Val Glu Asp Ser Val Leu Gln
     160                 165                 170

 tac gcg gcc tgg ggt gtc caa ggg cag cag ctg att tat att ttt gaa      696
 Tyr Ala Ala Trp Gly Val Gln Gly Gln Gln Leu Ile Tyr Ile Phe Glu
 175                 180                 185                 190

 aat aat atc tac tat caa cct gat ata aag agc agt tca ttg cga ctg      744
 Asn Asn Ile Tyr Tyr Gln Pro Asp Ile Lys Ser Ser Ser Leu Arg Leu
                 195                 200                 205

 aca tct tct gga aaa gaa gaa ata att ttt aat ggg att gct gac tgg      792
 Thr Ser Ser Gly Lys Glu Glu Ile Ile Phe Asn Gly Ile Ala Asp Trp
             210                 215                 220

 tta tat gaa gag gaa ctc ctg cat tct cac atc gcc cac tgg tgg tca      840
 Leu Tyr Glu Glu Glu Leu Leu His Ser His Ile Ala His Trp Trp Ser
         225                 230                 235

 cca gat gga gaa aga ctt gcc ttc ctg atg ata aat gac tct ttg gta      888
 Pro Asp Gly Glu Arg Leu Ala Phe Leu Met Ile Asn Asp Ser Leu Val
     240                 245                 250

 ccc acc atg gtt atc cct cgg ttt act gga gcg ttg tat ccc aaa gga      936
 Pro Thr Met Val Ile Pro Arg Phe Thr Gly Ala Leu Tyr Pro Lys Gly
 255                 260                 265                 270

 aag cag tat ccg tat cct aag gca ggt caa gtg aac cca aca ata aaa      984
 Lys Gln Tyr Pro Tyr Pro Lys Ala Gly Gln Val Asn Pro Thr Ile Lys
                 275                 280                 285

 tta tat gtt gta aac ctg tat gga cca act cac act ttg gag ctc atg     1032
 Leu Tyr Val Val Asn Leu Tyr Gly Pro Thr His Thr Leu Glu Leu Met
             290                 295                 300

 cca cct gac agc ttt aaa tca aga gaa tac tat atc act atg gtt aaa     1080
 Pro Pro Asp Ser Phe Lys Ser Arg Glu Tyr Tyr Ile Thr Met Val Lys
         305                 310                 315

 tgg gta agc aat acc aag act gtg gta aga tgg tta aac cga gct cag     1128
 Trp Val Ser Asn Thr Lys Thr Val Val Arg Trp Leu Asn Arg Ala Gln
     320                 325                 330

 aac atc tcc atc ctc aca gtc tgt gag acc act aca ggt gct tgt agt     1176
 Asn Ile Ser Ile Leu Thr Val Cys Glu Thr Thr Thr Gly Ala Cys Ser
 335                 340                 345                 350

 aaa aaa tat gag atg aca tca gat acg tgg ctc tct cag cgg aat gag     1224
 Lys Lys Tyr Glu Met Thr Ser Asp Thr Trp Leu Ser Gln Arg Asn Glu
                 355                 360                 365

 gag ccc gtg ttt tct aga gac ggc agc aaa ttc ttt atg aca gtg cct     1272
 Glu Pro Val Phe Ser Arg Asp Gly Ser Lys Phe Phe Met Thr Val Pro
             370                 375                 380

 gtt aag caa ggg gga cgt gga gaa ttt cac cac ata gct atg ttc ctc     1320
 Val Lys Gln Gly Gly Arg Gly Glu Phe His His Ile Ala Met Phe Leu
         385                 390                 395

 atc cag agt aaa agt gag caa att acc gtg cgg cat ctg aca tca gga     1368
 Ile Gln Ser Lys Ser Glu Gln Ile Thr Val Arg His Leu Thr Ser Gly
     400                 405                 410

 aac tgg gaa gtg ata aag atc ttg gca tac gat gaa act act caa aaa     1416
 Asn Trp Glu Val Ile Lys Ile Leu Ala Tyr Asp Glu Thr Thr Gln Lys
 415                 420                 425                 430

 att tac ttt ctg agc act gaa tct tct ccc aga gga agg cag ctg tac     1464
 Ile Tyr Phe Leu Ser Thr Glu Ser Ser Pro Arg Gly Arg Gln Leu Tyr
                 435                 440                 445

 agt gct tct act gaa gga tta ttg aat cgc caa tgc att tca tgt aat     1512
 Ser Ala Ser Thr Glu Gly Leu Leu Asn Arg Gln Cys Ile Ser Cys Asn
             450                 455                 460

 ttc atg aaa gaa caa tgt aca tat ttt gat gcc agt ttt agt ccc atg     1560
 Phe Met Lys Glu Gln Cys Thr Tyr Phe Asp Ala Ser Phe Ser Pro Met
         465                 470                 475

 aat caa cat ttc tta tta ttc tgt gaa ggt cca agg gtc cca gtg gtc     1608
 Asn Gln His Phe Leu Leu Phe Cys Glu Gly Pro Arg Val Pro Val Val
     480                 485                 490

 agc cta cat agt acg gac aac cca gca aaa tat ttt ata ttg gaa agc     1656
 Ser Leu His Ser Thr Asp Asn Pro Ala Lys Tyr Phe Ile Leu Glu Ser
 495                 500                 505                 510

 aat tct atg ctg aag gaa gct atc ctg aag aag aag ata gga aag cca     1704
 Asn Ser Met Leu Lys Glu Ala Ile Leu Lys Lys Lys Ile Gly Lys Pro
                 515                 520                 525

 gaa att aaa atc ctt cat att gac gac tat gaa ctt cct tta cag ttg     1752
 Glu Ile Lys Ile Leu His Ile Asp Asp Tyr Glu Leu Pro Leu Gln Leu
             530                 535                 540

 tcc ctt ccc aaa gat ttt atg gac cga aac cag tat gct ctt ctg tta     1800
 Ser Leu Pro Lys Asp Phe Met Asp Arg Asn Gln Tyr Ala Leu Leu Leu
         545                 550                 555

 ata atg gat gaa gaa cca gga ggc cag ctg gtt aca gat aag ttc cat     1848
 Ile Met Asp Glu Glu Pro Gly Gly Gln Leu Val Thr Asp Lys Phe His
     560                 565                 570

 att gac tgg gat tcc gta ctc att gac atg gat aat gtc att gta gca     1896
 Ile Asp Trp Asp Ser Val Leu Ile Asp Met Asp Asn Val Ile Val Ala
 575                 580                 585                 590

 aga ttt gat ggc aga gga agt gga ttc cag ggt ctg aaa att ttg cag     1944
 Arg Phe Asp Gly Arg Gly Ser Gly Phe Gln Gly Leu Lys Ile Leu Gln
                 595                 600                 605

 gag att cat cga aga tta ggt tca gta gaa gta aag gac caa ata aca     1992
 Glu Ile His Arg Arg Leu Gly Ser Val Glu Val Lys Asp Gln Ile Thr
             610                 615                 620

 gct gtg aaa ttt ttg ctg aaa ctg cct tac att gac tcc aaa aga tta     2040
 Ala Val Lys Phe Leu Leu Lys Leu Pro Tyr Ile Asp Ser Lys Arg Leu
         625                 630                 635

 agc att ttt gga aag ggt tat ggt ggc tat att gca tca atg atc tta     2088
 Ser Ile Phe Gly Lys Gly Tyr Gly Gly Tyr Ile Ala Ser Met Ile Leu
     640                 645                 650

 aaa tca gat gaa aag ctt ttt aaa tgt gga tcc gtg gtt gca cct atc     2136
 Lys Ser Asp Glu Lys Leu Phe Lys Cys Gly Ser Val Val Ala Pro Ile
 655                 660                 665                 670

 aca gac ttg aaa ttg tat gcc tca gct ttc tct gaa aga tac ctt ggg     2184
 Thr Asp Leu Lys Leu Tyr Ala Ser Ala Phe Ser Glu Arg Tyr Leu Gly
                 675                 680                 685

 atg cca tct aag gaa gaa agc act tac cag gca gcc agt gtg cta cat     2232
 Met Pro Ser Lys Glu Glu Ser Thr Tyr Gln Ala Ala Ser Val Leu His
             690                 695                 700

 aat gtt cat ggc ttg aaa gaa gaa aat ata tta ata att cat gga act     2280
 Asn Val His Gly Leu Lys Glu Glu Asn Ile Leu Ile Ile His Gly Thr
         705                 710                 715

 gct gac aca aaa gtt cat ttc caa cac tca gca gaa tta atc aag cac     2328
 Ala Asp Thr Lys Val His Phe Gln His Ser Ala Glu Leu Ile Lys His
     720                 725                 730

 cta ata aaa gct gga gtg aat tat act atg cag gtc tac cca gat gaa     2376
 Leu Ile Lys Ala Gly Val Asn Tyr Thr Met Gln Val Tyr Pro Asp Glu
 735                 740                 745                 750

 ggt cat aac gta tct gag aag agc aag tat cat ctc tac agc aca atc     2424
 Gly His Asn Val Ser Glu Lys Ser Lys Tyr His Leu Tyr Ser Thr Ile
                 755                 760                 765

 ctc aaa ttc ttc agt gat tgt ttg aag gaa gaa ata tct gtg cta cca     2472
 Leu Lys Phe Phe Ser Asp Cys Leu Lys Glu Glu Ile Ser Val Leu Pro
             770                 775                 780

 cag gaa cca gaa gaa gat gaa taa tggaccgtat ttatacagaa ctgaagggaa    2526
 Gln Glu Pro Glu Glu Asp Glu 
         785

 tattgaggct caatgaaacc tgacaaagag actgtaatat tgtagttgct ccagaatgtc   2586

 aagggcagct tacggagatg tcactggagc agcacgctca gagacagtga actagcattt   2646

 gaatacacaa gtccaagtct actgtgttgc taggggtgca gaacccgttt ctttgtatga   2706

 gagaggtcaa agggttggtt tcctgggaga aattagtttt gcattaaagt aggagtagtg   2766

 catgttttct tctgttatcc ccctgtttgt tctgtaacta gttgctctca ttttaatttc   2826

 actggccacc atcatctttg catataatgc acaatctatc atctgtccta cagtccctga   2886

 tctttcatgg ctgagctgca atctaacact ttactgtacc tttataataa gtgcaattct   2946

 ttcattgtct attattatgc ttaagaaaat attcagttaa taaaaaacag agtattttat   3006

 gtaaaaaaaa aaaa                                                     3020




      <210> 145
      <211> 1550
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(671)

      <400> 145
 aaggatcctt aattaaatta atcccccccc ccccgccggc ctccgcccgc ctcccgggtc     60

 agcggcgcgg gtgctgcgcc tagctgcgca cc  atg gcc ggg ttg ctg gcg ttg     113
                                      Met Ala Gly Leu Leu Ala Leu
                                        1               5

 ctg ggt ccg gca ggc agg gtg ggc gcc cgg gtc cgg cct cgc gcc acc      161
 Leu Gly Pro Ala Gly Arg Val Gly Ala Arg Val Arg Pro Arg Ala Thr
          10                  15                  20

 tgg ctc ctg ggc gcc acc gcc ccc tgc gcc ccg ccg ccc ctg gcc ctg      209
 Trp Leu Leu Gly Ala Thr Ala Pro Cys Ala Pro Pro Pro Leu Ala Leu
      25                  30                  35

 gcc ctg ctc ccg ccc agg cta gac gcc cgg ctg ctc cgc acg gcg cgc      257
 Ala Leu Leu Pro Pro Arg Leu Asp Ala Arg Leu Leu Arg Thr Ala Arg
  40                  45                  50                  55

 ggg gac tgc cgc ggc cac cag gac ccc agc cag gcc acg ggg aca aca      305
 Gly Asp Cys Arg Gly His Gln Asp Pro Ser Gln Ala Thr Gly Thr Thr
                  60                  65                  70

 ggc agc agc gtc agc tgc aca gag gag aaa aag caa agc aag tca cag      353
 Gly Ser Ser Val Ser Cys Thr Glu Glu Lys Lys Gln Ser Lys Ser Gln
              75                  80                  85

 caa ctg aaa aag att ttt caa gag tat ggc act gtt ggc gtg tca ttg      401
 Gln Leu Lys Lys Ile Phe Gln Glu Tyr Gly Thr Val Gly Val Ser Leu
          90                  95                 100

 cac att gga atc tca tta att tcc ttg ggc ata ttt tac atg gtt gtg      449
 His Ile Gly Ile Ser Leu Ile Ser Leu Gly Ile Phe Tyr Met Val Val
     105                 110                 115

 tca agt ggt gtg gac atg cct gca atc ctg ctg aaa ctc gga ttt aaa      497
 Ser Ser Gly Val Asp Met Pro Ala Ile Leu Leu Lys Leu Gly Phe Lys
 120                 125                 130                 135

 gag tcc ctg gta cag tca aaa atg gca gca ggc aca agt acc ttc gtg      545
 Glu Ser Leu Val Gln Ser Lys Met Ala Ala Gly Thr Ser Thr Phe Val
                 140                 145                 150

 gtg gcc tat gca atc cac aag ctg ttt gcg cca gtg aga atc agc att      593
 Val Ala Tyr Ala Ile His Lys Leu Phe Ala Pro Val Arg Ile Ser Ile
             155                 160                 165

 acg cta gtc tct gtg ccc ttg att gtc aga tat ttt cga aaa gtg gga      641
 Thr Leu Val Ser Val Pro Leu Ile Val Arg Tyr Phe Arg Lys Val Gly
         170                 175                 180

 ttt ttt aaa cct cca gct gca aaa cct taa t gaactcttca gtcgtacaca      692
 Phe Phe Lys Pro Pro Ala Ala Lys Pro 
     185                 190

 ctgaaaacct atttcttcta aattacatga tttggattgg ttttagggtt ttagggttgt    752

 agggtttctt ttggagaggt agggggctaa ttgctatgtt ctcatggata aactttgcca    812

 gcaaaaatca ggcttttgaa caattttaat tttttgcctc ataaattttg tgaatgctat    872

 tcattatagg gcttgtatat ataatctaaa atgtcagcaa ggcatcggag atgggttaac    932

 atctcaaaac aaaatagcct acaaatgttc cttgtgggag actttggcga gggtctgtgg    992

 gtaaaagcac cagggggtta atcttggctc agtttcctaa aaagcattga ttaatttaac   1052

 tggcttttaa atatcccctt ccgctgatat ttgttgtcag ctgcctacag tttaatatgc   1112

 agcgttcaca aaacagctgc cagtgctaca attaatgaag caaaacttaa tatgtaatca   1172

 caatctaaat tagcatcaat actttgacat tcattacatt ggtttggggg aagaaaagta   1232

 tttctggtat gtttcattga tccccagata ccttccaatc tggacatgat ggggctgatt   1292

 ccagatggtt tttctgaaat ttcattaagg taggtcagcg tcatttgtct ctgtttaggt   1352

 aaaatataaa aaccctgccc agtagcagtg gcatcgcttg gttcctgatg cccatgttcc   1412

 agaggaattc ggataccaca aacagctaag acaatctcag cttttcttag acaatcttct   1472

 atctcaaact tcagacattc cagaattgtc atgatgttta cactgtctga gttaaaaatc   1532

 ctgttcaaga aaaaaaaa                                                 1550




      <210> 146
      <211> 1783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(1487)

      <400> 146
 ccggactctg ccgcggaaga cccacgcgta cccacgcagg cgtacaccat ggtgaggtcc     60

 atgtgccgat gactgctgcc tctctgggct gatgatgctc ccccgcctgc tgttgctcct    120

 ccatctccag atcggatcac ggtgagggaa ag  atg agc gag gag acg gcg act     173
                                      Met Ser Glu Glu Thr Ala Thr
                                        1               5

 tct gac aac gac aat agt tat gca cga gtg cga gct gtg gtg atg acc      221
 Ser Asp Asn Asp Asn Ser Tyr Ala Arg Val Arg Ala Val Val Met Thr
          10                  15                  20

 cga gat gac tca agt ggt gga tgg tta cca ctt gga ggg agt gga cta      269
 Arg Asp Asp Ser Ser Gly Gly Trp Leu Pro Leu Gly Gly Ser Gly Leu
      25                  30                  35

 agc agc gtc act gtc ttc aaa gtc cct cat cag gaa gag aat ggc tgt      317
 Ser Ser Val Thr Val Phe Lys Val Pro His Gln Glu Glu Asn Gly Cys
  40                  45                  50                  55

 gct gac ttt ttt atc cgt gga gag cga ctc agg gac aaa atg gtg gtt      365
 Ala Asp Phe Phe Ile Arg Gly Glu Arg Leu Arg Asp Lys Met Val Val
                  60                  65                  70

 ttg gaa tgt atg ctt aaa aaa gac ctc att tat aat aag gtc act cca      413
 Leu Glu Cys Met Leu Lys Lys Asp Leu Ile Tyr Asn Lys Val Thr Pro
              75                  80                  85

 aca ttt cac cac tgg aag att gat gac aaa aag ttt ggt ctt acg ttt      461
 Thr Phe His His Trp Lys Ile Asp Asp Lys Lys Phe Gly Leu Thr Phe
          90                  95                 100

 caa agt cct gct gat gct agg gct ttt gat aga ggt atc cga aga gct      509
 Gln Ser Pro Ala Asp Ala Arg Ala Phe Asp Arg Gly Ile Arg Arg Ala
     105                 110                 115

 ata gag gat att tct caa gga tgc ccc gaa tca aaa aat gaa gct gaa      557
 Ile Glu Asp Ile Ser Gln Gly Cys Pro Glu Ser Lys Asn Glu Ala Glu
 120                 125                 130                 135

 ggg gca gat gac tta caa gca aat gaa gag gat tct tcc agt tct cta      605
 Gly Ala Asp Asp Leu Gln Ala Asn Glu Glu Asp Ser Ser Ser Ser Leu
                 140                 145                 150

 gtg aag gat cac ctt ttt cag caa gag aca gtt gtt acc agt gag cct      653
 Val Lys Asp His Leu Phe Gln Gln Glu Thr Val Val Thr Ser Glu Pro
             155                 160                 165

 tat aga agc tca aat ata aga cct tct ccc ttt gaa gat ctg aat gcc      701
 Tyr Arg Ser Ser Asn Ile Arg Pro Ser Pro Phe Glu Asp Leu Asn Ala
         170                 175                 180

 aga aga gtc tac atg caa agc caa gcc aat cag ata aca ttt ggt cag      749
 Arg Arg Val Tyr Met Gln Ser Gln Ala Asn Gln Ile Thr Phe Gly Gln
     185                 190                 195

 cca ggc ttg gac att cag agc aga agt atg gaa tac gta cag cgg caa      797
 Pro Gly Leu Asp Ile Gln Ser Arg Ser Met Glu Tyr Val Gln Arg Gln
 200                 205                 210                 215

 ata tcc aag gaa tgt gga agc cta aag tcc caa aat agg gtc cct ttg      845
 Ile Ser Lys Glu Cys Gly Ser Leu Lys Ser Gln Asn Arg Val Pro Leu
                 220                 225                 230

 aaa tca atc aga cat gtc agc ttt caa gat gag gat gag att gtc aga      893
 Lys Ser Ile Arg His Val Ser Phe Gln Asp Glu Asp Glu Ile Val Arg
             235                 240                 245

 ata aac cct cga gat atc tta ata cgt cgc tat gca gac tac aga cat      941
 Ile Asn Pro Arg Asp Ile Leu Ile Arg Arg Tyr Ala Asp Tyr Arg His
         250                 255                 260

 cct gac atg tgg aaa aat gac ttg gaa aga gat gat gct gat tcc agt      989
 Pro Asp Met Trp Lys Asn Asp Leu Glu Arg Asp Asp Ala Asp Ser Ser
     265                 270                 275

 att cag ttt tct aaa cca gac agt aaa aaa tca gac tat ctg tac tct     1037
 Ile Gln Phe Ser Lys Pro Asp Ser Lys Lys Ser Asp Tyr Leu Tyr Ser
 280                 285                 290                 295

 tgt ggg gat gag act aag tta agt tca ccc aaa gac tct gtg gta ttt     1085
 Cys Gly Asp Glu Thr Lys Leu Ser Ser Pro Lys Asp Ser Val Val Phe
                 300                 305                 310

 aag acg cag cct tcc tca tta aaa att aag aag tca aaa cga aga aaa     1133
 Lys Thr Gln Pro Ser Ser Leu Lys Ile Lys Lys Ser Lys Arg Arg Lys
             315                 320                 325

 gag gat ggt gaa cgt tct cgc tgc gta tac tgc cag gaa agg ttt aat     1181
 Glu Asp Gly Glu Arg Ser Arg Cys Val Tyr Cys Gln Glu Arg Phe Asn
         330                 335                 340

 cat gaa gaa aat gtc agg gga aaa tgt cag gat gct cca gac cct att     1229
 His Glu Glu Asn Val Arg Gly Lys Cys Gln Asp Ala Pro Asp Pro Ile
     345                 350                 355

 aaa aga tgc ata tat caa gtt agt tgc atg ctc tgt gca gag agc atg     1277
 Lys Arg Cys Ile Tyr Gln Val Ser Cys Met Leu Cys Ala Glu Ser Met
 360                 365                 370                 375

 ttg tat cat tgt atg tca gac tca gag gga gat ttt tct gat ccc tgt     1325
 Leu Tyr His Cys Met Ser Asp Ser Glu Gly Asp Phe Ser Asp Pro Cys
                 380                 385                 390

 tcg tgt gac act agc gac gac aag ttc tgc ttg cga tgg tta gcc ctg     1373
 Ser Cys Asp Thr Ser Asp Asp Lys Phe Cys Leu Arg Trp Leu Ala Leu
             395                 400                 405

 gta gct ttg tct ttc att gta cca tgt atg tgc tgg tac gtc cct ttg     1421
 Val Ala Leu Ser Phe Ile Val Pro Cys Met Cys Trp Tyr Val Pro Leu
         410                 415                 420

 aga atg tgc cat cgc tgt ggt gag gca tgt ggt tgc tgt ggt ggg aaa     1469
 Arg Met Cys His Arg Cys Gly Glu Ala Cys Gly Cys Cys Gly Gly Lys
     425                 430                 435

 cat aaa gct gct gga tga aatggt ccagtgccaa aatgagctta aaatctttgt     1523
 His Lys Ala Ala Gly 
 440

 tttcaggaat taagctaact tggatttgtg gaagcttttg gcaagcaata tggaatcttg   1583

 cctggtatca ttgagcccac acatggagga agcagaactc atcagttctt ggcgtttcac   1643

 gccatgccta acttttccct tgagtgcatg gcatgttttg ttacaggttg tagagtattt   1703

 gcagaaggaa accatttctg gttatttggc tataaaaagt cagcataaaa tatgatccaa   1763

 ctaaaaggga aaaaaaaaaa                                               1783




      <210> 147
      <211> 1906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(1856)

      <400> 147
 actagtccag agtggtggaa ttcgcgccga gcggtggcgt cgttgtcgcc ccctcctcgt     60

 cgggaagaat cgtttggtct cctgccgtgc ccggccggtg ctgctgtcgc tgctgctgcc    120

 cgcgcgggtt gtgg  atg ttg tcg gct ccg tgt tgt gat gac agg aga atg     170
                  Met Leu Ser Ala Pro Cys Cys Asp Asp Arg Arg Met
                    1               5                  10

 tgt gtg tgt ccc ggg ccc aga cga att gga atc cca gtc aga agt tcc      218
 Cys Val Cys Pro Gly Pro Arg Arg Ile Gly Ile Pro Val Arg Ser Ser
          15                  20                  25

 agc ctg cca ctg ttc tct gat gcc atg cca gca cca act caa ctg ttt      266
 Ser Leu Pro Leu Phe Ser Asp Ala Met Pro Ala Pro Thr Gln Leu Phe
      30                  35                  40

 ttt cct ctc atc cgt aac tgt gaa ctg agc agg atc tat ggc act gca      314
 Phe Pro Leu Ile Arg Asn Cys Glu Leu Ser Arg Ile Tyr Gly Thr Ala
  45                  50                  55                  60

 tgt tac tgc cac cac aaa cat ctc tgt tgt tcc tca tcg tac att cct      362
 Cys Tyr Cys His His Lys His Leu Cys Cys Ser Ser Ser Tyr Ile Pro
                  65                  70                  75

 cag agt cga ctg aga tac aca cct cat cca gca tat gct acc ttt tgc      410
 Gln Ser Arg Leu Arg Tyr Thr Pro His Pro Ala Tyr Ala Thr Phe Cys
              80                  85                  90

 agg cca aag gag aac tgg tgg cag tac acc caa gga agg aga tat gct      458
 Arg Pro Lys Glu Asn Trp Trp Gln Tyr Thr Gln Gly Arg Arg Tyr Ala
          95                 100                 105

 tcc aca cca cag aaa ttt tac ctc aca cct cca caa gtc aat agc atc      506
 Ser Thr Pro Gln Lys Phe Tyr Leu Thr Pro Pro Gln Val Asn Ser Ile
     110                 115                 120

 ctt aaa gct aat gaa tac agt ttc aaa gtg cca gaa ttt gac ggc aaa      554
 Leu Lys Ala Asn Glu Tyr Ser Phe Lys Val Pro Glu Phe Asp Gly Lys
 125                 130                 135                 140

 atg tca gtt cta tcc ttg gat ttg aca gca atc aag ctg cct gca aat      602
 Met Ser Val Leu Ser Leu Asp Leu Thr Ala Ile Lys Leu Pro Ala Asn
                 145                 150                 155

 gca ccc att gag gac cgg aga agt gca gca acc tgc ttg cag acc aga      650
 Ala Pro Ile Glu Asp Arg Arg Ser Ala Ala Thr Cys Leu Gln Thr Arg
             160                 165                 170

 ggg atg ctt ttg ggg gtt ttt gat ggc cat gca ggt tgt gct tgg tcc      698
 Gly Met Leu Leu Gly Val Phe Asp Gly His Ala Gly Cys Ala Trp Ser
         175                 180                 185

 cag gca gtc agt gaa aga ctc ttt tat tat att gct ggc tct ttg gta      746
 Gln Ala Val Ser Glu Arg Leu Phe Tyr Tyr Ile Ala Gly Ser Leu Val
     190                 195                 200

 ccc cat gag act ttg cta gag att gaa aat gca gtg gag agc ggc cgg      794
 Pro His Glu Thr Leu Leu Glu Ile Glu Asn Ala Val Glu Ser Gly Arg
 205                 210                 215                 220

 gca ctg cta ccc att ctc cag tgg cac aag cac ccc aat gat tac ttt      842
 Ala Leu Leu Pro Ile Leu Gln Trp His Lys His Pro Asn Asp Tyr Phe
                 225                 230                 235

 agt aag gag gca tcc aaa ttg tac ttt aac agc ttg agg act tac tgg      890
 Ser Lys Glu Ala Ser Lys Leu Tyr Phe Asn Ser Leu Arg Thr Tyr Trp
             240                 245                 250

 caa gag ctt ata gac ctc aac act ggt gag tcg act gat att gat gtt      938
 Gln Glu Leu Ile Asp Leu Asn Thr Gly Glu Ser Thr Asp Ile Asp Val
         255                 260                 265

 aag gag gct cta att aat gcc ttc aag agg ctt gat aat gac atc tcc      986
 Lys Glu Ala Leu Ile Asn Ala Phe Lys Arg Leu Asp Asn Asp Ile Ser
     270                 275                 280

 ttg gag gcg caa gtt ggt gat cct aat tct ttt ctc aac tac ctg gtg     1034
 Leu Glu Ala Gln Val Gly Asp Pro Asn Ser Phe Leu Asn Tyr Leu Val
 285                 290                 295                 300

 ctt cga gtg gca ttt tct gga gcc act gct tgt gtg gcc cat gtg gat     1082
 Leu Arg Val Ala Phe Ser Gly Ala Thr Ala Cys Val Ala His Val Asp
                 305                 310                 315

 ggt gtt gac ctt cat gtg gcc aat act ggc gat agc aga gcc atg ctg     1130
 Gly Val Asp Leu His Val Ala Asn Thr Gly Asp Ser Arg Ala Met Leu
             320                 325                 330

 ggt gtg cag gaa gag gac ggc tca tgg tca gca gtc acg ctg tct aat     1178
 Gly Val Gln Glu Glu Asp Gly Ser Trp Ser Ala Val Thr Leu Ser Asn
         335                 340                 345

 gac cac aat gct caa aat gaa aga gaa cta gaa cgg ctg aaa ttg gaa     1226
 Asp His Asn Ala Gln Asn Glu Arg Glu Leu Glu Arg Leu Lys Leu Glu
     350                 355                 360

 cat cca aag agt gag gcc aag agt gtc gtg aaa cag gat cgg ctg ctt     1274
 His Pro Lys Ser Glu Ala Lys Ser Val Val Lys Gln Asp Arg Leu Leu
 365                 370                 375                 380

 ggc ttg ctg atg cca ttt agg gca ttt gga gat gta aag ttc aaa tgg     1322
 Gly Leu Leu Met Pro Phe Arg Ala Phe Gly Asp Val Lys Phe Lys Trp
                 385                 390                 395

 agc att gac ctt caa aag aga gtg ata gaa tct ggc cca gac cag ttg     1370
 Ser Ile Asp Leu Gln Lys Arg Val Ile Glu Ser Gly Pro Asp Gln Leu
             400                 405                 410

 aat gac aat gaa tat acc aag ttt att cct cct aat tat cac aca cct     1418
 Asn Asp Asn Glu Tyr Thr Lys Phe Ile Pro Pro Asn Tyr His Thr Pro
         415                 420                 425

 cct tat ctc act gct gag cca gag gta act tac cac cga tta agg cca     1466
 Pro Tyr Leu Thr Ala Glu Pro Glu Val Thr Tyr His Arg Leu Arg Pro
     430                 435                 440

 cag gat aag ttt ctg gtg ttg gct act gat ggg ttg tgg gag act atg     1514
 Gln Asp Lys Phe Leu Val Leu Ala Thr Asp Gly Leu Trp Glu Thr Met
 445                 450                 455                 460

 cat agg cag gat gtg gtt agg att gtg ggt gag tac cta act ggc atg     1562
 His Arg Gln Asp Val Val Arg Ile Val Gly Glu Tyr Leu Thr Gly Met
                 465                 470                 475

 cat cac caa cag cca ata gct gtt ggt ggc tac aag gtg act ctg gga     1610
 His His Gln Gln Pro Ile Ala Val Gly Gly Tyr Lys Val Thr Leu Gly
             480                 485                 490

 cag atg cat ggc ctt tta aca gaa agg aga acc aaa atg tcc tcg gta     1658
 Gln Met His Gly Leu Leu Thr Glu Arg Arg Thr Lys Met Ser Ser Val
         495                 500                 505

 ttt gag gat cag aac gca gca acc cat ctc att cgc cac gct gtg ggc     1706
 Phe Glu Asp Gln Asn Ala Ala Thr His Leu Ile Arg His Ala Val Gly
     510                 515                 520

 aac aac gag ttt ggg act gtt gat cat gag cgc ctc tct aaa atg ctt     1754
 Asn Asn Glu Phe Gly Thr Val Asp His Glu Arg Leu Ser Lys Met Leu
 525                 530                 535                 540

 agt ctt cct gaa gag ctt gct cga atg tac aga gat gac att aca atc     1802
 Ser Leu Pro Glu Glu Leu Ala Arg Met Tyr Arg Asp Asp Ile Thr Ile
                 545                 550                 555

 att gta gtt cag ttc aat tct cat gtt gta ggg gcg tat caa aac caa     1850
 Ile Val Val Gln Phe Asn Ser His Val Val Gly Ala Tyr Gln Asn Gln
             560                 565                 570

 gaa tag tgagtggctc tttcactggc aattctcaaa tgatacacat ttaaagggca      1906
 Glu 






      <210> 148
      <211> 1651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (783)..(1604)

      <400> 148
 gtaattcttt ggtcgaccca cgcgtccgga gagagataaa agagagggag agggagtgag     60

 agagagattt agagggagag gggaagagag agaaagagag agaggagaga gaagaaacgg    120

 gaggagggga taaggaaatt aaacccttta agtcaatgca tattgtggtg acaccggcac    180

 aggcgccctc acggtggagt cggccagggc tgtgcgttcc caaaatatga ccaggggtgc    240

 ttggatgtgt cggcagtatg acgacggctt aaaaatctgg ttggcagcac cccgagagaa    300

 cgagaaaccg ttcatcgatt ccgagagggc tcagaaatgg cgactgtctc tggcatctct    360

 cttgtttttc acagtcctgc tctctgatca cttgtggttc tgcgccgagg ccaagctgac    420

 ccgggcccgg gacaaggagc accagcagca gcagcggcag cagcagcagc agcagcagca    480

 gcagaggcag cggcagcagc agcagcagca gcggcggcag caggagccct cctggcccgc    540

 gctcctggcg agcatggggg agtcctcgcc cgccgcccag gcacacagac tcctctccgc    600

 ctcctcgtcc cccaccctgc ccccctcccc gggagacggc ggcggcggcg gcggcaaggg    660

 caaccgaggc aaagacgacc ggggcaaggc tctttttcta ggaaactctg ccaagcccgt    720

 gtggcgcctg gagacttgtt acccccaggg cgcgtcctcg ggccagtgct tcacggtgga    780

 ga   atg cgg acg cgg tgt gcg cca gga act gga gtc ggg ggg cgg ccg     827
      Met Arg Thr Arg Cys Ala Pro Gly Thr Gly Val Gly Gly Arg Pro
        1               5                  10                  15

 ggg ggg gac ggg cag gag gtg agg agc aag cat ccc act ccg ctc tgg      875
 Gly Gly Asp Gly Gln Glu Val Arg Ser Lys His Pro Thr Pro Leu Trp
                  20                  25                  30

 aac ttg tcg gat ttt tac ctt tcg ttt tgt aat tcc tac aca ctt tgg      923
 Asn Leu Ser Asp Phe Tyr Leu Ser Phe Cys Asn Ser Tyr Thr Leu Trp
              35                  40                  45

 gag ttg ttc tcg ggg ttg tcc agt ccc aac act ttg aac tgc agt ctg      971
 Glu Leu Phe Ser Gly Leu Ser Ser Pro Asn Thr Leu Asn Cys Ser Leu
          50                  55                  60

 gat gtg gtg ctc aag gaa ggc ggc gag atg acc act tgc agg cag tgc     1019
 Asp Val Val Leu Lys Glu Gly Gly Glu Met Thr Thr Cys Arg Gln Cys
      65                  70                  75

 gtc gag gct tac cag gac tat gac cac cat gct cag gag aaa tac gaa     1067
 Val Glu Ala Tyr Gln Asp Tyr Asp His His Ala Gln Glu Lys Tyr Glu
  80                  85                  90                  95

 gag ttt gaa agc gtg ctc cac aaa tat tta cag tcg gag gag tac tcg     1115
 Glu Phe Glu Ser Val Leu His Lys Tyr Leu Gln Ser Glu Glu Tyr Ser
                 100                 105                 110

 gtg aaa tcc tgt cct gaa gac tgt aag att gtc tac aaa gcc tgg ctc     1163
 Val Lys Ser Cys Pro Glu Asp Cys Lys Ile Val Tyr Lys Ala Trp Leu
             115                 120                 125

 tgt tcc cag tat ttt gaa gtc aca cag ttt aac tgc aga aag aca att     1211
 Cys Ser Gln Tyr Phe Glu Val Thr Gln Phe Asn Cys Arg Lys Thr Ile
         130                 135                 140

 cct tgc aag caa tac tgt ttg gag gtt cag acg agg tgt cca ttt ata     1259
 Pro Cys Lys Gln Tyr Cys Leu Glu Val Gln Thr Arg Cys Pro Phe Ile
     145                 150                 155

 ttg ccc gac aat gat gaa gtc atc tac gga ggc ctc tcc agt ttc atc     1307
 Leu Pro Asp Asn Asp Glu Val Ile Tyr Gly Gly Leu Ser Ser Phe Ile
 160                 165                 170                 175

 tgt aca ggg ctt tat gaa acc ttt cta acc aat gat gaa cca gaa tgc     1355
 Cys Thr Gly Leu Tyr Glu Thr Phe Leu Thr Asn Asp Glu Pro Glu Cys
                 180                 185                 190

 tgt gac gtc agg aga gaa gaa aaa tca aat aac cca tcc aaa ggg acc     1403
 Cys Asp Val Arg Arg Glu Glu Lys Ser Asn Asn Pro Ser Lys Gly Thr
             195                 200                 205

 gta gag aaa agt ggc tcc tgt cac agg aca tcg ctc aca gtg tca tca     1451
 Val Glu Lys Ser Gly Ser Cys His Arg Thr Ser Leu Thr Val Ser Ser
         210                 215                 220

 gca aca aga ctg tgc aac agc aga ctc aag ctg tgt gtt ctt gta ctg     1499
 Ala Thr Arg Leu Cys Asn Ser Arg Leu Lys Leu Cys Val Leu Val Leu
     225                 230                 235

 att ctc tta cac aca gtg ctc aca gcc tcg gca gca cag aac aca gcc     1547
 Ile Leu Leu His Thr Val Leu Thr Ala Ser Ala Ala Gln Asn Thr Ala
 240                 245                 250                 255

 gga ctg agc ttt gga ggc atc aac acg ctg gaa gaa aac tca acc aat     1595
 Gly Leu Ser Phe Gly Gly Ile Asn Thr Leu Glu Glu Asn Ser Thr Asn
                 260                 265                 270

 gag gag taa cggaagg acgagtgtca ccacagcagc agctggcccg ccgtgaaaaa     1651
 Glu Glu 






      <210> 149
      <211> 1621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(1274)

      <400> 149
 ccgatccgga attcccgtgt cgacccacgc gtccgccgtc ctccgcccgc gcccgacgga     60

 gcctgttcgc gtcgactgcc cagagtccgc gaatcctccg ctccgagccc gtccggactc    120

 ccccgatccc agctttctct cctttgaaaa cactaagaat a    atg tca ctg cat     173
                                                  Met Ser Leu His
                                                    1

 cag ttt tta cta gag cca atc acc tgt cat gcc tgg aac agg gat cgt      221
 Gln Phe Leu Leu Glu Pro Ile Thr Cys His Ala Trp Asn Arg Asp Arg
   5                  10                  15                  20

 act cag att gcc ctc agt ccc aat aat cac gaa gtg cac atc tat aag      269
 Thr Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val His Ile Tyr Lys
                  25                  30                  35

 aag aac ggg agc cag tgg gtg aaa gct cat gaa ctc aag gag cac aac      317
 Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu Lys Glu His Asn
              40                  45                  50

 gga cac atc aca ggt att gac tgg gct ccc aag agc gac cgc att gtc      365
 Gly His Ile Thr Gly Ile Asp Trp Ala Pro Lys Ser Asp Arg Ile Val
          55                  60                  65

 act tgt ggg gca gac cgc aat gcc tat gtc tgg agt cag aaa gat ggt      413
 Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser Gln Lys Asp Gly
      70                  75                  80

 gtt tgg aag cca acc ctg gtg atc ctg aga att aat cgc gca gct act      461
 Val Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn Arg Ala Ala Thr
  85                  90                  95                 100

 ttt gtg aag tgg tcc ccc cta gag aac aaa ttt gct gtg gga agt gga      509
 Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala Val Gly Ser Gly
                 105                 110                 115

 gca cga ctc att tct gtt tgt tac ttt gag tct gaa aat gac tgg tgg      557
 Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu Ser Glu Asn Asp Trp Trp
             120                 125                 130

 gtg agc aag cac att aaa aag ccg att cgc tcc aca gtc ctc agc ttg      605
 Val Ser Lys His Ile Lys Lys Pro Ile Arg Ser Thr Val Leu Ser Leu
         135                 140                 145

 gat tgg cat ccc aac aac gtt ttg ctg gca gca gga tca tgt gac ttc      653
 Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly Ser Cys Asp Phe
     150                 155                 160

 aaa tgc aga gtg ttt tct gcc tac att aaa gaa gtg gat gaa aag cca      701
 Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys Glu Val Asp Glu Lys Pro
 165                 170                 175                 180

 gcc agc acg ccc tgg ggc agc aag atg cct ttt ggg cag ctg atg tca      749
 Ala Ser Thr Pro Trp Gly Ser Lys Met Pro Phe Gly Gln Leu Met Ser
                 185                 190                 195

 gag ttt ggt ggc agt ggc act ggt ggc tgg gtc cac ggg gta agc ttc      797
 Glu Phe Gly Gly Ser Gly Thr Gly Gly Trp Val His Gly Val Ser Phe
             200                 205                 210

 tct gcc agt ggg agc cgc ctg gcc tgg gtc agc cac gac agc acc gtg      845
 Ser Ala Ser Gly Ser Arg Leu Ala Trp Val Ser His Asp Ser Thr Val
         215                 220                 225

 tct gtt gct gat gcc tca aaa agt gtg cag gtc tcg act ctg aag aca      893
 Ser Val Ala Asp Ala Ser Lys Ser Val Gln Val Ser Thr Leu Lys Thr
     230                 235                 240

 gag ttc ctg ccg ctc cta agt gtg tca ttt gtc tca gag aac agc gtc      941
 Glu Phe Leu Pro Leu Leu Ser Val Ser Phe Val Ser Glu Asn Ser Val
 245                 250                 255                 260

 gtg gct gct ggc cat gac tgc tgc cca atg ctc ttt aac tac gat gac      989
 Val Ala Ala Gly His Asp Cys Cys Pro Met Leu Phe Asn Tyr Asp Asp
                 265                 270                 275

 cgc ggc tgc ctg acc ttc gtc tcc aag tta gat att cca aaa cag agc     1037
 Arg Gly Cys Leu Thr Phe Val Ser Lys Leu Asp Ile Pro Lys Gln Ser
             280                 285                 290

 atc caa cgc aac atg tct gcc atg gaa cgc ttc cgc aac atg gac aag     1085
 Ile Gln Arg Asn Met Ser Ala Met Glu Arg Phe Arg Asn Met Asp Lys
         295                 300                 305

 aga gcc aca act gag gac cgc aac acg gcc ttg gag acg ctg cac cag     1133
 Arg Ala Thr Thr Glu Asp Arg Asn Thr Ala Leu Glu Thr Leu His Gln
     310                 315                 320

 aat agc atc act caa gtc tct att tat gag gtg gac aag caa gat tgt     1181
 Asn Ser Ile Thr Gln Val Ser Ile Tyr Glu Val Asp Lys Gln Asp Cys
 325                 330                 335                 340

 cgc aaa ttt tgc act act ggc atc gat gga gcc atg aca att tgg gat     1229
 Arg Lys Phe Cys Thr Thr Gly Ile Asp Gly Ala Met Thr Ile Trp Asp
                 345                 350                 355

 ttc aag acc ctc gag tct tcc atc cag ggc ctc cgg ata atg tga agc     1277
 Phe Lys Thr Leu Glu Ser Ser Ile Gln Gly Leu Arg Ile Met 
             360                 365                 370

 tgagtgagcc tccgccatcc agcatgacaa actgtggccg accgcagctg tgccgtggca   1337

 cgatggcgag gaagccagcc ccaaggaaac actgaaaaca catatcacgc caatgccgtg   1397

 tggttttgtt tgaatataaa attggtgaaa gtgttggttt ttttaaggca gtaatttttt   1457

 tgtttgtttt tttgcgattt cattccattc ttgaccaaag cttctcttta agtagtttat   1517

 tatggaaaat tgtcacacta acttaaaaga cagggtgagg gagatatgta aattgtccac   1577

 tagaaaatta aataaaagaa ctgaatgtgg ttaaaaaaaa aaaa                    1621




      <210> 150
      <211> 3135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (349)..(954)

      <400> 150
 cgatgtttaa tatgatcact atagggaatt tggccctgcg aggcagagaa ttcggcacga     60

 gggcgagcgg cacgtgtcag gccaccgagg tccaagccgc acttgctgcc ccattgagga    120

 cgaggaggca gcaggagcag tgacggtgac tctaaggagc cggattcccg gcacgcagag    180

 ctgacctgcc tggcacccgc ggccctctcc tgtttccttc ccattgtgtt ggcaccctaa    240

 aaagaaagaa taaaacaaca acaggaaaaa aaggaaaata tttaaattgt gacaaaaacc    300

 cactgggttc tcttggttac aaactccttc ccttctggtg ctgcaaaa atg agt ggg     357
                                                      Met Ser Gly
                                                        1

 aaa tcc ctg ctc tta aag gtc att ctc ttg ggt gat ggt gga gtt ggg      405
 Lys Ser Leu Leu Leu Lys Val Ile Leu Leu Gly Asp Gly Gly Val Gly
       5                  10                  15

 aaa agt tcg ctt atg aac cgt tac gta acc aac aaa ttt gac tcc cag      453
 Lys Ser Ser Leu Met Asn Arg Tyr Val Thr Asn Lys Phe Asp Ser Gln
  20                  25                  30                  35

 gct ttt cac acc ata ggg gta gag ttc tta aat cga gat ctg gag gta      501
 Ala Phe His Thr Ile Gly Val Glu Phe Leu Asn Arg Asp Leu Glu Val
                  40                  45                  50

 gat gga cgc ttt gta acc ctc cag atc tgg gac act gca ggg cag gaa      549
 Asp Gly Arg Phe Val Thr Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu
              55                  60                  65

 cgt ttc aag agc ctt agg aca ccc ttc tac agg gga gca gac tgc tgc      597
 Arg Phe Lys Ser Leu Arg Thr Pro Phe Tyr Arg Gly Ala Asp Cys Cys
          70                  75                  80

 ctc ttg acc ttc agc gtg gat gat cgg cag agc ttc gag aat ctt ggt      645
 Leu Leu Thr Phe Ser Val Asp Asp Arg Gln Ser Phe Glu Asn Leu Gly
      85                  90                  95

 aac tgg cag aaa gaa ttt att tac tat gcg gat gtg aag gac cct gag      693
 Asn Trp Gln Lys Glu Phe Ile Tyr Tyr Ala Asp Val Lys Asp Pro Glu
 100                 105                 110                 115

 cat ttc ccc ttt gta gtt ctg ggt aac aag gta gac aaa gag gat agg      741
 His Phe Pro Phe Val Val Leu Gly Asn Lys Val Asp Lys Glu Asp Arg
                 120                 125                 130

 caa gtg act act gag gag gca caa acc tgg tgc atg gag aat ggg gat      789
 Gln Val Thr Thr Glu Glu Ala Gln Thr Trp Cys Met Glu Asn Gly Asp
             135                 140                 145

 tac cct tat tta gaa act agt gcc aaa gat gat act aat gtg aca gtg      837
 Tyr Pro Tyr Leu Glu Thr Ser Ala Lys Asp Asp Thr Asn Val Thr Val
         150                 155                 160

 gcc ttt gaa gaa gct gtc agg cag gtg ctg gct gta gag gaa cag ctg      885
 Ala Phe Glu Glu Ala Val Arg Gln Val Leu Ala Val Glu Glu Gln Leu
     165                 170                 175

 gag cat tgc atg ttg ggt cac acc att gac ttg aac agt ggc tcc aaa      933
 Glu His Cys Met Leu Gly His Thr Ile Asp Leu Asn Ser Gly Ser Lys
 180                 185                 190                 195

 gca ggg tct tcg tgc tgt taa ag atagggagcc ttttaaaaat gtgccccaaa      986
 Ala Gly Ser Ser Cys Cys 
                 200

 ttgatcagtc agtagtgtaa gaataactgt gcccctctaa gagtgcacac acacgcacac   1046

 aagagggtaa gagacaaggt tctgattgtg aaacagagcc tttcaaattg aagtgtagat   1106

 tgatttaaaa aaaaaaaaaa ttaaaaaaaa tgaagctcta tcaagccaag tgtattttgc   1166

 gtgatttctg ctatttcccc ttcttgtgtg tctcaggaca tatcagaaaa ttttagtcct   1226

 gagacagtta aatatttttt aaatcacagt ttaaacctag aacccagctg catgaaggag   1286

 ttaaagagct acaactattt cttaaagtgt tccattaatc aactaacaaa tgtcactatc   1346

 agactcttgc caagcagttt ctgacatttc tgccaaaggg gaaaaaaatc agactttgag   1406

 ctgtattaca ataaaaataa taatgcaaat aaggattcct aggcttgaat taaagaagtt   1466

 gtaatgatta ggagtgcaaa agtataatga tatacactga cttgtttaaa tccttatgta   1526

 tggttcgctc ccatctgagc ttttcaaaaa atcccatctc aataagagat actctaatga   1586

 cactggcaat tgattatact tcttgtgttt gaagtcatag gatactagtg aatggattat   1646

 gcttaaatat gccaaccacc tttgcaaata aatggttggt ctgcttttaa ttcctaagtc   1706

 tacttttgct gcatagagat gttgcttctc tgacaacctc ttaccaattt agcaatgctg   1766

 cttagtatat gaatttggat gcagtgctct ctgctcatca tttagatggt cctttgatcc   1826

 aacatgctgg gctcatggag aaggcttcat aaaagattgg gggataatga acttttctca   1886

 caaggctcct taactcaaat atttattgca gaagaaggaa ctggtttctt atatgttgca   1946

 ctgtatgttc aactagccta attaggacat tgaaagtgac agaagagcag atcttaaccc   2006

 agtgttagaa tgaatttccc ataaacagag ttgtccaaca gtggaatgga ctgccttaat   2066

 agtgagctcc ctgcctctga aaatattcac tggatgacca tctgttagaa taccataaaa   2126

 agattttctg tgctggctac atgttcaata taaagtcctt tctggctcta agttctatga   2186

 atatataaac tacatcagtg ccatgctgtg gttagattta tctgatgata acagctaaga   2246

 ctatggagag ggactttaaa aattctcaaa ccattctgtg atcaatcttt aacagcaact   2306

 acatagctct tccttttgct tttgcactgt ggcaggaaaa attcttgagc tctgagtaat   2366

 ctttatgtga ctgataaaaa acatcttaaa gctcccatgt taaaatataa aaatggtttg   2426

 acaatttttg attaccatga ctgtcagtta tatactatat tatgaatatg cagtgtggtt   2486

 cttgttggtt gatctgttta ccctgcatag attttaatct gtactttaaa acatctatga   2546

 taaaaatagt gacagacaga aattacccca aaaagagacc taggccagga agggggtggg   2606

 agctttcata ggaatacagc ctagaactct ccattgtagc cacgtatgga atcagcctta   2666

 cttacatgta ggacctttgt gctttaagag ctctgggaca tattggccaa atagaaaaga   2726

 agaggacagt atttcaactc agtcatactc aatatttcca attaagatat aatcctgaca   2786

 ccattgttca attaactttg acgccagaag tcaaagccag aactgggacc ccacagctct   2846

 taagtactgg tccctatcct gcctatgcct atagccagcc acactggttt ccaagttctg   2906

 tgatcatttt gctacaatca tgttagggtg aaaatctgta cgtcagaact gttaaatgct   2966

 aattattttt aagtgcatga gacctggggc cttctctttc tacttgcact ctgcttatac   3026

 tagtttctat ttgtagatct caggccttca tcataaagac ctctatcaac tcacaaaagt   3086

 atttgtctct attagagtgg catgtggtca tttgagtaaa aaaaaaaaa               3135




      <210> 151
      <211> 6921
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(4374)

      <400> 151
 ctggacgccg agctgggtgc gcagcagcgc gagctgcagg aggcgctggg cgcgcgcgcc     60

 gccctcgagg cgctgctggg ccgactgcag gccgagcgcc gaggcctcga cgcggcccac    120

 gaacgcgacg tgagggagct gcgcgcgcgc gccgccagcc ttacc    atg cat ttc     174
                                                      Met His Phe
                                                        1

 cgc gcc cgc gcc acc ggc ccc gcc gcg ccg ccg cca cgc ctg cgg gag      222
 Arg Ala Arg Ala Thr Gly Pro Ala Ala Pro Pro Pro Arg Leu Arg Glu
       5                  10                  15

 gtg cac gac agc tac gca ctg ctg gtg gcc gag tcg tgg cgg gag acg      270
 Val His Asp Ser Tyr Ala Leu Leu Val Ala Glu Ser Trp Arg Glu Thr
  20                  25                  30                  35

 gtg cag ctg tac gag gac gag gtg cgc gag ctg gag gag gcg ctg cgg      318
 Val Gln Leu Tyr Glu Asp Glu Val Arg Glu Leu Glu Glu Ala Leu Arg
                  40                  45                  50

 cgc ggc cag gag agc aga ctc cag gcg gag gaa gag acg cgg ctg tgc      366
 Arg Gly Gln Glu Ser Arg Leu Gln Ala Glu Glu Glu Thr Arg Leu Cys
              55                  60                  65

 gcg cag gag gca gag gcg ctg cgg cgc gag gcg ctc ggg ttg gag cag      414
 Ala Gln Glu Ala Glu Ala Leu Arg Arg Glu Ala Leu Gly Leu Glu Gln
          70                  75                  80

 ctg cgc gcg cgg ctg gag gac gcg ctg ctg cgg atg cgc gag gag tac      462
 Leu Arg Ala Arg Leu Glu Asp Ala Leu Leu Arg Met Arg Glu Glu Tyr
      85                  90                  95

 ggg ata cag gcc gag gag cgg cag aga gcg att gac tgc ctg gag gat      510
 Gly Ile Gln Ala Glu Glu Arg Gln Arg Ala Ile Asp Cys Leu Glu Asp
 100                 105                 110                 115

 gag aag gca acc ctc acc ttg gcc atg gct gac tgg ctg cgg gac tat      558
 Glu Lys Ala Thr Leu Thr Leu Ala Met Ala Asp Trp Leu Arg Asp Tyr
                 120                 125                 130

 cag gac ctc ctg cag gtg aag acc ggc ctc agt ctg gag gtg gcg acc      606
 Gln Asp Leu Leu Gln Val Lys Thr Gly Leu Ser Leu Glu Val Ala Thr
             135                 140                 145

 tac cgg gcc tta ttg gaa gga gaa agt aat cca gag ata gtg atc tgg      654
 Tyr Arg Ala Leu Leu Glu Gly Glu Ser Asn Pro Glu Ile Val Ile Trp
         150                 155                 160

 gct gag cac gtt gaa aac atg ccg tca gaa ttc aga aac aaa tcc tat      702
 Ala Glu His Val Glu Asn Met Pro Ser Glu Phe Arg Asn Lys Ser Tyr
     165                 170                 175

 cac tat acc gac tca cta cta cag agg gaa aat gaa tgg aat cta ttt      750
 His Tyr Thr Asp Ser Leu Leu Gln Arg Glu Asn Glu Trp Asn Leu Phe
 180                 185                 190                 195

 tca agg cag aaa gca cct ttg gca agt ttc aat cac agc tcg gca ctg      798
 Ser Arg Gln Lys Ala Pro Leu Ala Ser Phe Asn His Ser Ser Ala Leu
                 200                 205                 210

 tat tct aac ctg tca ggg cac cgt gga tct cag acg ggc aca tct att      846
 Tyr Ser Asn Leu Ser Gly His Arg Gly Ser Gln Thr Gly Thr Ser Ile
             215                 220                 225

 gga ggt gat gcc aga aga ggc ttc ttg ggc tcg gga tat tct tcc tcg      894
 Gly Gly Asp Ala Arg Arg Gly Phe Leu Gly Ser Gly Tyr Ser Ser Ser
         230                 235                 240

 gcc act acc cag cag gaa aac tca tac gga aaa gcc gtc agc agt caa      942
 Ala Thr Thr Gln Gln Glu Asn Ser Tyr Gly Lys Ala Val Ser Ser Gln
     245                 250                 255

 acc aac gtc aga act ttc tct cca acc tat ggc ctt tta aga aat act      990
 Thr Asn Val Arg Thr Phe Ser Pro Thr Tyr Gly Leu Leu Arg Asn Thr
 260                 265                 270                 275

 gag gct caa gtg aaa aca ttc cct gac aga cca aaa gcc gga gat aca     1038
 Glu Ala Gln Val Lys Thr Phe Pro Asp Arg Pro Lys Ala Gly Asp Thr
                 280                 285                 290

 agg gag gtc ccc gtt tac ata ggt gaa gat tcc aca att gcc cgc gag     1086
 Arg Glu Val Pro Val Tyr Ile Gly Glu Asp Ser Thr Ile Ala Arg Glu
             295                 300                 305

 tcg tac cgg gat cgc cga gac aag gtg gca gca ggt gct tcg gaa agc     1134
 Ser Tyr Arg Asp Arg Arg Asp Lys Val Ala Ala Gly Ala Ser Glu Ser
         310                 315                 320

 aca cgg tca aat gag agg acc gtc att ctg gga aag aaa aca gaa gtg     1182
 Thr Arg Ser Asn Glu Arg Thr Val Ile Leu Gly Lys Lys Thr Glu Val
     325                 330                 335

 aaa gcc acg agg gag caa gaa aga aac aga cca gaa acc atc cga aca     1230
 Lys Ala Thr Arg Glu Gln Glu Arg Asn Arg Pro Glu Thr Ile Arg Thr
 340                 345                 350                 355

 aag cca gaa gag aaa atg ttc gat tct aaa gag aag gct tcc gag gag     1278
 Lys Pro Glu Glu Lys Met Phe Asp Ser Lys Glu Lys Ala Ser Glu Glu
                 360                 365                 370

 aga aac cta aga tgg gaa gaa ttg aca aag tta gat aag gaa gcg aga     1326
 Arg Asn Leu Arg Trp Glu Glu Leu Thr Lys Leu Asp Lys Glu Ala Arg
             375                 380                 385

 cag aga gaa agc cag cag atg aag gag aag gct aag gag aag gac tca     1374
 Gln Arg Glu Ser Gln Gln Met Lys Glu Lys Ala Lys Glu Lys Asp Ser
         390                 395                 400

 ccg aag gag aag agc gtg cga gag aga gag gtg ccg att agt cta gaa     1422
 Pro Lys Glu Lys Ser Val Arg Glu Arg Glu Val Pro Ile Ser Leu Glu
     405                 410                 415

 gta tcc cag gac aga aga gca gag gtg tcc ccg aaa ggt ttg cag acg     1470
 Val Ser Gln Asp Arg Arg Ala Glu Val Ser Pro Lys Gly Leu Gln Thr
 420                 425                 430                 435

 cct gtg aag gat gct ggt ggt ggg acc ggt aga gag gca gaa gca aga     1518
 Pro Val Lys Asp Ala Gly Gly Gly Thr Gly Arg Glu Ala Glu Ala Arg
                 440                 445                 450

 gag cta cgg ttc agg ttg ggc acc agt gat gcc act ggt tct ctg caa     1566
 Glu Leu Arg Phe Arg Leu Gly Thr Ser Asp Ala Thr Gly Ser Leu Gln
             455                 460                 465

 ggc gat tcc atg aca gaa acc gta gca gaa aac atc gtt acc agt atc     1614
 Gly Asp Ser Met Thr Glu Thr Val Ala Glu Asn Ile Val Thr Ser Ile
         470                 475                 480

 ctg aag cag ttc act cag tct cca gag aca gaa gca tct gct gat tct     1662
 Leu Lys Gln Phe Thr Gln Ser Pro Glu Thr Glu Ala Ser Ala Asp Ser
     485                 490                 495

 ttt cca gac aca aaa gtc act tac gtg gac agg aaa gag ctt cct ggg     1710
 Phe Pro Asp Thr Lys Val Thr Tyr Val Asp Arg Lys Glu Leu Pro Gly
 500                 505                 510                 515

 gaa agg aaa aca aag act gaa ata gtt gtg gag tct aaa ctg act gag     1758
 Glu Arg Lys Thr Lys Thr Glu Ile Val Val Glu Ser Lys Leu Thr Glu
                 520                 525                 530

 gat gtt gat gtt tcc gat gaa gct ggc ctg gac tac ctt tta agc aag     1806
 Asp Val Asp Val Ser Asp Glu Ala Gly Leu Asp Tyr Leu Leu Ser Lys
             535                 540                 545

 gat att aag gaa gtg ggg ctg aaa ggc aag tca gcc gag cag atg ata     1854
 Asp Ile Lys Glu Val Gly Leu Lys Gly Lys Ser Ala Glu Gln Met Ile
         550                 555                 560

 gga gac atc atc aac ctc ggc ctg aaa ggg agg gag ggg aga gca aag     1902
 Gly Asp Ile Ile Asn Leu Gly Leu Lys Gly Arg Glu Gly Arg Ala Lys
     565                 570                 575

 gtc gtc aac gtg gag atc gtg gag gag ccc gtg agt tat gtc agc ggg     1950
 Val Val Asn Val Glu Ile Val Glu Glu Pro Val Ser Tyr Val Ser Gly
 580                 585                 590                 595

 gag aag ccg gag gag ttt tcc gtc cca ttc aaa gtg gag gag gtc gaa     1998
 Glu Lys Pro Glu Glu Phe Ser Val Pro Phe Lys Val Glu Glu Val Glu
                 600                 605                 610

 gat gtg tcg cca ggc ccc tgg ggg ttg gtt aag gag gag gaa ggt tat     2046
 Asp Val Ser Pro Gly Pro Trp Gly Leu Val Lys Glu Glu Glu Gly Tyr
             615                 620                 625

 gga gaa agc gat gtc aca ttc tca gtt aat cag cat cga agg acc aag     2094
 Gly Glu Ser Asp Val Thr Phe Ser Val Asn Gln His Arg Arg Thr Lys
         630                 635                 640

 cag ccc cag gag aac acg act cac gtg gaa gaa gtg aca gag gca ggt     2142
 Gln Pro Gln Glu Asn Thr Thr His Val Glu Glu Val Thr Glu Ala Gly
     645                 650                 655

 gat tca gag ggc gag cag agt tat ttt gtg tcc act cca gat gaa cac     2190
 Asp Ser Glu Gly Glu Gln Ser Tyr Phe Val Ser Thr Pro Asp Glu His
 660                 665                 670                 675

 ccc ggg ggg cac gac aga gat gac ggc tcg gtg tac ggg cag atc cac     2238
 Pro Gly Gly His Asp Arg Asp Asp Gly Ser Val Tyr Gly Gln Ile His
                 680                 685                 690

 atc gag gag gaa tcc acc atc agg tac tct tgg cag gat gaa atc gtg     2286
 Ile Glu Glu Glu Ser Thr Ile Arg Tyr Ser Trp Gln Asp Glu Ile Val
             695                 700                 705

 cag ggg act cga agg agg aca cag aag gac ggt gca gtg ggc gag aag     2334
 Gln Gly Thr Arg Arg Arg Thr Gln Lys Asp Gly Ala Val Gly Glu Lys
         710                 715                 720

 gtt gtg aag ccc ttg gat gtc cca gcg ccc tct ctg gag ggg gac ctg     2382
 Val Val Lys Pro Leu Asp Val Pro Ala Pro Ser Leu Glu Gly Asp Leu
     725                 730                 735

 ggt tcc act cac tgg aaa gaa caa gct aga agc ggt gaa ttt cat gcc     2430
 Gly Ser Thr His Trp Lys Glu Gln Ala Arg Ser Gly Glu Phe His Ala
 740                 745                 750                 755

 gaa ccc aca gtc att gaa aaa gaa att aaa ata ccc cac gaa ttc cac     2478
 Glu Pro Thr Val Ile Glu Lys Glu Ile Lys Ile Pro His Glu Phe His
                 760                 765                 770

 acc tcc atg aag ggc atc tcc tcc aag gag ccc cgg cag cag ctg gtg     2526
 Thr Ser Met Lys Gly Ile Ser Ser Lys Glu Pro Arg Gln Gln Leu Val
             775                 780                 785

 gag gtc atc ggg cag ctg gag gaa acc ctt ccc gag cgc atg agg gag     2574
 Glu Val Ile Gly Gln Leu Glu Glu Thr Leu Pro Glu Arg Met Arg Glu
         790                 795                 800

 gag ctg tcc gcc ctc acc aga gag ggg cag ggt ggg ccg ggg agc gtt     2622
 Glu Leu Ser Ala Leu Thr Arg Glu Gly Gln Gly Gly Pro Gly Ser Val
     805                 810                 815

 tcc gtg gat gtc aag aag gtc cag ggt gct ggt ggc agt tcc gtg acc     2670
 Ser Val Asp Val Lys Lys Val Gln Gly Ala Gly Gly Ser Ser Val Thr
 820                 825                 830                 835

 ctg gtt gct gaa gtc aac gtc tca caa act gtg gat gcc gat cgg tta     2718
 Leu Val Ala Glu Val Asn Val Ser Gln Thr Val Asp Ala Asp Arg Leu
                 840                 845                 850

 gac ctg gag gag ctg agc aaa gat gag gcc agt gag atg gag aag gct     2766
 Asp Leu Glu Glu Leu Ser Lys Asp Glu Ala Ser Glu Met Glu Lys Ala
             855                 860                 865

 gtg gag tcg gtg gtt cgg gag agc ctg agc agg caa cgc agc cca gcg     2814
 Val Glu Ser Val Val Arg Glu Ser Leu Ser Arg Gln Arg Ser Pro Ala
         870                 875                 880

 cct ggc agc cca gat gag gaa ggt gga gcg gag gcc ccg gct gct ggc     2862
 Pro Gly Ser Pro Asp Glu Glu Gly Gly Ala Glu Ala Pro Ala Ala Gly
     885                 890                 895

 att cgc ttc agg cgt tgg gcc acc cgg gag ctg tac atc cct tca ggc     2910
 Ile Arg Phe Arg Arg Trp Ala Thr Arg Glu Leu Tyr Ile Pro Ser Gly
 900                 905                 910                 915

 gag agc gag gtt gct ggt ggg gcc tct cac agc tcg gga cag cgc act     2958
 Glu Ser Glu Val Ala Gly Gly Ala Ser His Ser Ser Gly Gln Arg Thr
                 920                 925                 930

 ccc cag ggc cca gtg tcg gcc act gtg gag gtc agc agc ccc aca ggc     3006
 Pro Gln Gly Pro Val Ser Ala Thr Val Glu Val Ser Ser Pro Thr Gly
             935                 940                 945

 ttt gcc cag tca cag gtg ctg gag gat gtg agc cag gct gca agg cac     3054
 Phe Ala Gln Ser Gln Val Leu Glu Asp Val Ser Gln Ala Ala Arg His
         950                 955                 960

 ata aaa ctc ggc ccc tct gaa gtc tgg agg act gag cga atg tca tat     3102
 Ile Lys Leu Gly Pro Ser Glu Val Trp Arg Thr Glu Arg Met Ser Tyr
     965                 970                 975

 gaa gga ccc act gca gaa gtg gtg gag gta agt gcg gga ggt gac cta     3150
 Glu Gly Pro Thr Ala Glu Val Val Glu Val Ser Ala Gly Gly Asp Leu
 980                 985                 990                 995

 agt cag gca gcg agc ccg acc gga gcc agc cgg tct gtg agg cat gtc     3198
 Ser Gln Ala Ala Ser Pro Thr Gly Ala Ser Arg Ser Val Arg His Val
                1000                1005                1010

 acg ctg ggt ccc ggt caa agt cca ctg tcc aga gaa gtc atc ttc cta     3246
 Thr Leu Gly Pro Gly Gln Ser Pro Leu Ser Arg Glu Val Ile Phe Leu
            1015                1020                1025

 ggc cct gcc cct gcc tgt cca gag gca tgg ggc tcg cca gaa cct ggc     3294
 Gly Pro Ala Pro Ala Cys Pro Glu Ala Trp Gly Ser Pro Glu Pro Gly
        1030                1035                1040

 cca gca gag tct tct gca gat atg gac gga tca ggg agg cac agc aca     3342
 Pro Ala Glu Ser Ser Ala Asp Met Asp Gly Ser Gly Arg His Ser Thr
    1045                1050                1055

 ttt ggc tgc aga caa ttt cat gct gaa aag gag att att ttt cag ggc     3390
 Phe Gly Cys Arg Gln Phe His Ala Glu Lys Glu Ile Ile Phe Gln Gly
1060                1065                1070                1075

 ccc att tct gct gca ggg aag gtt ggt gat tat ttt gca aca gaa gag     3438
 Pro Ile Ser Ala Ala Gly Lys Val Gly Asp Tyr Phe Ala Thr Glu Glu
                1080                1085                1090

 tca gtg ggt acc cag act tct gtc agg caa ctc cag tta ggc cct aaa     3486
 Ser Val Gly Thr Gln Thr Ser Val Arg Gln Leu Gln Leu Gly Pro Lys
            1095                1100                1105

 gaa ggg ttc agt ggg caa atc cag ttc aca gct cca ctt tca gac aag     3534
 Glu Gly Phe Ser Gly Gln Ile Gln Phe Thr Ala Pro Leu Ser Asp Lys
        1110                1115                1120

 gtg gag ttg ggt gtc ata gga gat tct gta cac atg gaa ggg ttg cca     3582
 Val Glu Leu Gly Val Ile Gly Asp Ser Val His Met Glu Gly Leu Pro
    1125                1130                1135

 ggg agc agc aca tcc atc agg cac atc agc att ggg cct cag agg cat     3630
 Gly Ser Ser Thr Ser Ile Arg His Ile Ser Ile Gly Pro Gln Arg His
1140                1145                1150                1155

 cag acc acc cag cag ata gtt tac cat ggg ctg gtt ccc caa ctg ggg     3678
 Gln Thr Thr Gln Gln Ile Val Tyr His Gly Leu Val Pro Gln Leu Gly
                1160                1165                1170

 gaa tct ggt gac tca gag agc act gtg cac gga gag ggc tca gca gat     3726
 Glu Ser Gly Asp Ser Glu Ser Thr Val His Gly Glu Gly Ser Ala Asp
            1175                1180                1185

 gtg cac cag gcc act cac agt cat acc tcg ggt aga caa acc gtt atg     3774
 Val His Gln Ala Thr His Ser His Thr Ser Gly Arg Gln Thr Val Met
        1190                1195                1200

 act gaa aag agc acc ttc caa agt gtc gtt tct gaa tct ccc cag gag     3822
 Thr Glu Lys Ser Thr Phe Gln Ser Val Val Ser Glu Ser Pro Gln Glu
    1205                1210                1215

 gat agt gca ggg gac aca tca ggg gca gaa atg aca tcg ggt gtt agc     3870
 Asp Ser Ala Gly Asp Thr Ser Gly Ala Glu Met Thr Ser Gly Val Ser
1220                1225                1230                1235

 aga tcc ttt agg cac att cga cta ggt cct aca gaa acg gaa acc tct     3918
 Arg Ser Phe Arg His Ile Arg Leu Gly Pro Thr Glu Thr Glu Thr Ser
                1240                1245                1250

 gaa cac att gcc atc cgt gga ccc gtg tcc aga aca ttt gtg ctt gct     3966
 Glu His Ile Ala Ile Arg Gly Pro Val Ser Arg Thr Phe Val Leu Ala
            1255                1260                1265

 ggt tca gcg gac tcc cct gag cta ggc aag tta gca gac agc agc aga     4014
 Gly Ser Ala Asp Ser Pro Glu Leu Gly Lys Leu Ala Asp Ser Ser Arg
        1270                1275                1280

 acg cta agg cac att gca cca ggg ccc aaa gaa act tcg ttt acc ttt     4062
 Thr Leu Arg His Ile Ala Pro Gly Pro Lys Glu Thr Ser Phe Thr Phe
    1285                1290                1295

 cag atg gat gtg agt aac gta gag gcg atc cgc agc cgg aca cag gaa     4110
 Gln Met Asp Val Ser Asn Val Glu Ala Ile Arg Ser Arg Thr Gln Glu
1300                1305                1310                1315

 gcg gga gct ctc ggt gtg tct gac cgt ggt tcc tgg aga gac gcg gac     4158
 Ala Gly Ala Leu Gly Val Ser Asp Arg Gly Ser Trp Arg Asp Ala Asp
                1320                1325                1330

 agt agg aat gac cag gca gtt ggt gtg agc ttt aag gcc tct gct ggg     4206
 Ser Arg Asn Asp Gln Ala Val Gly Val Ser Phe Lys Ala Ser Ala Gly
            1335                1340                1345

 gaa gga gac cag gcc cac aga gaa cag ggc aag gag cag gcc atg ttt     4254
 Glu Gly Asp Gln Ala His Arg Glu Gln Gly Lys Glu Gln Ala Met Phe
        1350                1355                1360

 gat aag aag gtg cag ctc cag aga atg gta gac caa agg tcg gtg att     4302
 Asp Lys Lys Val Gln Leu Gln Arg Met Val Asp Gln Arg Ser Val Ile
    1365                1370                1375

 tca gat gaa aag aaa gtt gcc ctc ctc tat cta gac aat gag gag gag     4350
 Ser Asp Glu Lys Lys Val Ala Leu Leu Tyr Leu Asp Asn Glu Glu Glu
1380                1385                1390                1395

 gag aat gat ggg cat tgg ttt taa taagcagaaa cattttgttt taatggcagc    4404
 Glu Asn Asp Gly His Trp Phe 
                1400

 ctgttggcga cgtgccaaca tccaaaggcc ttaacttatt ttaagaggcc gagggagtct   4464

 atgaaaatct cccctttttt acttttttaa agagtactcc cggcatggtc aatttccttt   4524

 atagttaatc cgtaaaggtt tccagttaat tcatgcctta aaaggcactg caattttatt   4584

 tttgagttgg gacttttaca aaacactttt ttccctggag tcttctctcc acttctggag   4644

 atgaatttct atgttttgca cctggtcaca gacatggctt gcatctgttt gaaactacaa   4704

 ttaattatag atgtcaaaac attaaccaga ttaaagtaat atatttaaga gtaaattttg   4764

 cttgcatgtg ctaatatgaa ataacagact aacattttag gggaaaaata aatacaattt   4824

 agactctaaa aagtcttttc aaaaagaaat gggaaatagg cagactgttt atgttaaaaa   4884

 aattcttgct aaatgatttc atctttagga aaaaattact tgccatatag agctaaattc   4944

 atcttaagac ttgaatgaat tgctttctat gtacagaact ttaaacaata tagtatttat   5004

 ggcgaggaca gctgtagtct gttgtgatat ttcacattct atttgcacag gttccctggc   5064

 actggtaggg tagatgatta ttgggaatcg cttacagtac catttcattt tttggcacta   5124

 ggtcattaag tagcacacag tctgaatgcc cttttctgga gtggccagtt cctatcagac   5184

 tgtgcagact tgcgcttctc tgcaccttat cccttagcac ccaaacattt aatttcactg   5244

 gtgggaggta gaccttgaag acaatgaaga gaatgccgat actcagactg cagctggacc   5304

 ggcaagctgg ctgtgtacag gaaaattgga agcacacagt ggactgtgcc tcttaaagat   5364

 gcctttccca accctccatt catgggatgc aggtctttct gagctcaagg gtgaaagatg   5424

 aatacaataa caaccatgaa cccacctcac ggaagctttt tttgcacttt gaacagaagt   5484

 cattgcagtt ggggtgtttt gtccagggaa acagtttatt aaatagaagg atgttttggg   5544

 gaaggaactg gatatctctc ctgcagccca gcaccgagat acccaggacg ggcctggggg   5604

 gcgagaaagg cccccatgct catgggccgc ggagtgtgga cctgtagata ggcaccaccg   5664

 agtttaagat actgggatga gcatgcttca ttggattcat tttattttac acgtcagtat   5724

 tgttttaaag tttctgtctg taaagtgtag catcatatat aaaaagagtt tcgctagcag   5784

 cgcatttttt ttagttcagg ctagcttctt tcacataatg ctgtctcagc tgtatttcca   5844

 gtaacacagc atcatcgcac tgactgtggc gcactgggga ataacagtct gagctagcac   5904

 caccctcagc caggctacaa cgacagcact ggagggtctt ccctctcaga ttcacctgga   5964

 ggccctcaga cccccagggt gcacgtctcc ccaggtcctg ggagtggcta ccgcaggtag   6024

 tttctggaga gcacgttttc ttcattgata agtggaggag aaatgcagca cagctttcaa   6084

 gatactattt taaaaacacc atgaatcaga tagggaaaga aagttgattg gaatggcaag   6144

 tttaaacctt tgttgtccat ctgccaaatg aactagtgat tgtcagactg gtatggaggt   6204

 gactgctttg taaggttttg tcgtttctaa tacagacaga gatgtgctga ttttgtttta   6264

 gctgtaacag gtaatggttt ttggatagat gattgactgg tgagaatttg gtcaaggtga   6324

 cagcctcctg tctgatgaca ggacagactg gtggtgagga gtctaagtgg gcttagtttg   6384

 atgtcagtgt ctgggctcat gacttgtaaa tggaagctga tgtgaacagg taattaatat   6444

 tatgacccac ttctatttac tttgggaaat atcttggatc ttaattatca tctgcaagtt   6504

 tcaagaagta ttctgccaaa agtatttaca agtatggact catgagctat tgttggttgc   6564

 taaatgtgaa tcacgcggga gtgagtgtgc ccttcacact gtgacattgt gacattgtga   6624

 caagctccat gtcctttaaa atcagtcact ctgcacacaa gagaaatcaa cttcgtggtt   6684

 ggatggggcc ggaacacaac cagtcttttt gtatttattg ttactgagac aaaacagtac   6744

 tcactgagtg tttttcagtt tcctactggt ggttttgata ttgtttgttt aagatgtata   6804

 tttagaatga catcatctaa gaagctgatt ttgctaaact cctgttccct acaatgggaa   6864

 atgtcacaag aatgtgcaaa aataaaaatc tgaggaaaaa acccaaaaaa aaaaaaa      6921




      <210> 152
      <211> 2353
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (239)..(1705)

      <400> 152
 ggtatttttt ctacatgtga gatcaaatga atatgcagtc aaaaaaggag agtcagtaca     60

 tggagaaata ttccagacag taatgttgga aagacatgaa agccacgaca tacaagattt    120

 ttgcttcaga gaaacccaga aaaatgtaca tgactctcag tgtctgtgga aacatgattg    180

 aagacattat aagcgagtgc gtgtgaccta taaggaaagt ctcattggta gaagagac      238                                                                 
 atg cat ggg aga aag gat gat gca caa aag cag cct gtt aaa aat cag      286
 Met His Gly Arg Lys Asp Asp Ala Gln Lys Gln Pro Val Lys Asn Gln
   1               5                  10                  15

 ctt gga tta aac ccg cag tca cat cta cca gaa ctg cag cta ttt caa      334
 Leu Gly Leu Asn Pro Gln Ser His Leu Pro Glu Leu Gln Leu Phe Gln
              20                  25                  30

 gct gaa ggg aaa ata tat aaa tat gat cac atg gaa aaa tct gtc aac      382
 Ala Glu Gly Lys Ile Tyr Lys Tyr Asp His Met Glu Lys Ser Val Asn
          35                  40                  45

 agt agt tcc tta gtt tcc cca ccc caa cgt att tct tct act gtc aaa      430
 Ser Ser Ser Leu Val Ser Pro Pro Gln Arg Ile Ser Ser Thr Val Lys
      50                  55                  60

 acc cac att tct cat aca tat gaa tgt aat ttt gtg gat tca tta ttc      478
 Thr His Ile Ser His Thr Tyr Glu Cys Asn Phe Val Asp Ser Leu Phe
  65                  70                  75                  80

 aca caa aaa gag aaa gca aat att ggg aca gaa cac tac aaa tgt agt      526
 Thr Gln Lys Glu Lys Ala Asn Ile Gly Thr Glu His Tyr Lys Cys Ser
                  85                  90                  95

 gag cgt ggc aag gcc ttt cat caa ggc tta cat ttt act ata cat caa      574
 Glu Arg Gly Lys Ala Phe His Gln Gly Leu His Phe Thr Ile His Gln
             100                 105                 110

 ata atc cat act aaa gag acg caa ttt aaa tgt gat ata tgt ggc aag      622
 Ile Ile His Thr Lys Glu Thr Gln Phe Lys Cys Asp Ile Cys Gly Lys
         115                 120                 125

 atc ttc aat aaa aaa tca aac ctt gca agt cat caa aga att cat act      670
 Ile Phe Asn Lys Lys Ser Asn Leu Ala Ser His Gln Arg Ile His Thr
     130                 135                 140

 gga gag aag cca tat aaa tgt aat gaa tgt ggc aag gtc ttc cat aat      718
 Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe His Asn
 145                 150                 155                 160

 atg tca cac ctt gca cag cat cgc agg att cat act gga gag aaa cca      766
 Met Ser His Leu Ala Gln His Arg Arg Ile His Thr Gly Glu Lys Pro
                 165                 170                 175

 tat aaa tgt aat gaa tgt ggc aag gtc ttt aat caa att tca cac ctt      814
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Asn Gln Ile Ser His Leu
             180                 185                 190

 gca caa cat caa aga att cat acc gga gag aaa cct tat aaa tgt aat      862
 Ala Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
         195                 200                 205

 gaa tgt gga aag gtc ttc cat caa att tca cac ctt gca caa cat cgg      910
 Glu Cys Gly Lys Val Phe His Gln Ile Ser His Leu Ala Gln His Arg
     210                 215                 220

 aca att cat act gga gaa aaa cct tac gaa tgt aac aaa tgt ggc aag      958
 Thr Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Gly Lys
 225                 230                 235                 240

 gtg ttc agt cgc aat tcc tac ctt gta caa cat ctg atc att cat act     1006
 Val Phe Ser Arg Asn Ser Tyr Leu Val Gln His Leu Ile Ile His Thr
                 245                 250                 255

 gga gag aaa cct tac aga tgt aat gta tgt ggc aag gtc ttc agt cac     1054
 Gly Glu Lys Pro Tyr Arg Cys Asn Val Cys Gly Lys Val Phe Ser His
             260                 265                 270

 aag tca tcc cta gta aat cac tgg aga att cat act gga gag aaa cct     1102
 Lys Ser Ser Leu Val Asn His Trp Arg Ile His Thr Gly Glu Lys Pro
         275                 280                 285

 tac aaa tgt aat gag tgt ggc aag gtc ttc agt cac aag tca tcc cta     1150
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser His Lys Ser Ser Leu
     290                 295                 300

 gta aat cac tgg aga atc cac act gga gag aaa cct tac aaa tgt aat     1198
 Val Asn His Trp Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
 305                 310                 315                 320

 gaa tgt ggc aag gtc ttc agt cgc aat tca tac ctt gcc caa cat ctg     1246
 Glu Cys Gly Lys Val Phe Ser Arg Asn Ser Tyr Leu Ala Gln His Leu
                 325                 330                 335

 ata att cat gcc ggt gag aaa cct tat aag tgt gat gaa tgt gac aaa     1294
 Ile Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Asp Lys
             340                 345                 350

 gca ttc agt caa aat tca cat ctt gta caa cat cac aga atc cat act     1342
 Ala Phe Ser Gln Asn Ser His Leu Val Gln His His Arg Ile His Thr
         355                 360                 365

 gga gag aaa cct tac aaa tgt gat gaa tgt ggc aaa gtc ttc agt caa     1390
 Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Val Phe Ser Gln
     370                 375                 380

 aat tca tac ctt gca tat cat tgg aga att cat act gga gaa aaa gct     1438
 Asn Ser Tyr Leu Ala Tyr His Trp Arg Ile His Thr Gly Glu Lys Ala
 385                 390                 395                 400

 tat aaa tgt aat gaa tgt ggg aag gtc ttc ggt cta aac tca tcc cta     1486
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Gly Leu Asn Ser Ser Leu
                 405                 410                 415

 gca cat cat cgg aaa att cac act gga gag aaa cct ttc aaa tgt aat     1534
 Ala His His Arg Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn
             420                 425                 430

 gaa tgt ggc aaa gct ttt agt atg cgt tca agc ctc act aat cat cat     1582
 Glu Cys Gly Lys Ala Phe Ser Met Arg Ser Ser Leu Thr Asn His His
         435                 440                 445

 gcg atc cac act gga gag aaa cat ttc aaa tgt aat gaa tgt ggc aaa     1630
 Ala Ile His Thr Gly Glu Lys His Phe Lys Cys Asn Glu Cys Gly Lys
     450                 455                 460

 ctc ttc cgc gac aat tca tat ctt gta cgt cat cag aga ttt cat gcc     1678
 Leu Phe Arg Asp Asn Ser Tyr Leu Val Arg His Gln Arg Phe His Ala
 465                 470                 475                 480

 gga aag aaa tct aac aca tgt aat taa tgtgg cagagtgttc agttagcatt     1730
 Gly Lys Lys Ser Asn Thr Cys Asn 
                 485

 aaagccttgt aagacataca ataatttata ctggagaaaa actttgcaag tataatgaat   1790

 gtagcagagc ctttagtttt tgttcaaggc ttaataaccg ttagctagac catagaggac   1850

 agaaacttta ctaatgtact gaatgtggca aggtcttaag gtaaaatctg agaccaggat   1910

 ttttcaaaga attcttgctg gtgagaaacc taacaaatgt aatgaatgtg gcaaggtctt   1970

 ctggcacaat tctcacattg tacaatattg caaaaattca tgcttgagag aaacaaaaac   2030

 actgagagtg ggaaaccatt atgacttcaa acattcatca acatcagaga atccatacta   2090

 aagagcattt ataataatta tatgtgatag agattttccg caggccaaag tctcactagg   2150

 catcaaaaac ttttttgatg aaaccataca aatgtaacgt gcatgcttaa gcttttaccc   2210

 aggcatcaaa accggaacat cacagggttt atactggaga gtaactacac aaagataatg   2270

 taataagcct ttcagtgtaa tattcatgat tttgtcgtga gagatccact caataaaaac   2330

 caggcaaatg taaaaaaaaa aaa                                           2353




      <210> 153
      <211> 1598
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (718)..(1551)

      <400> 153
 tttttttgaa aaaagacatt tggaattgtt tgaaaaacta tttaccttct ataatcattt     60

 tcctaaaaat actacattgg aaattgaaaa aacaaaagat atcaaatata atgaatattt    120

 attcaaaaag attacaatgt gattttcttt ttctagtttc tcaactcatt ggatgctaaa    180

 gaaatatatt tggaagtaat acataatctt ccagattttg aactactttc ggcaaacaca    240

 ctagaggatc gtttggctca tcatcggtgg ctgttatttt ttcattttgg aaaaaatgaa    300

 aattcaaatg atcctgagct gaaaaaacta aaaactctac ttaaaaatga tcatattcaa    360

 gttggcaggt ttgactgttc ctctgcacca gacatctgta gtaatctgta tgtttttcag    420

 ccgtctctag cagtatttaa aggacaagga accaaagaat atgaaattca tcatggaaag    480

 aagattctat atgatatact tgcctttgcc aaagaaagtg tgaattctca tgttaccacg    540

 cttggacctc aaaattttcc tgccaatgac aaagaaccat ggcttgttga tttctttgcc    600

 ccctggtgtc caccatgtcg agctttacta ccagagttac gaagagcatc aaatcttctt    660

 tatggtcagc ttaagtttgg tacactagat tgtacagttc atgagggact ctgtaac       717                                                                 
 atg tat aac att cag gct tat cca aca aca gtg gta ttc aac cag tcc      765
 Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val Phe Asn Gln Ser
   1               5                  10                  15

 aac att cat gag tat gaa gga cat cac tct gct gaa caa atc ttg gag      813
 Asn Ile His Glu Tyr Glu Gly His His Ser Ala Glu Gln Ile Leu Glu
              20                  25                  30

 ttc ata gag gat ctt atg aat cct tca gtg gtc tcc ctt aca ccc acc      861
 Phe Ile Glu Asp Leu Met Asn Pro Ser Val Val Ser Leu Thr Pro Thr
          35                  40                  45

 acc ttc aac gaa cta gtt aca caa aga aaa cac aac gaa gtc tgg atg      909
 Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn Glu Val Trp Met
      50                  55                  60

 gtt gat ttc tat tct ccg tgg tgt cat cct tgc caa gtc tta atg cca      957
 Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln Val Leu Met Pro
  65                  70                  75                  80

 gaa tgg aaa aga atg gcc cgg aca tta act gga ctg atc aac gtg ggc     1005
 Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu Ile Asn Val Gly
                  85                  90                  95

 agt ata gat tgc caa cag tat cat tct ttt tgt gcc cag gaa aac gtt     1053
 Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala Gln Glu Asn Val
             100                 105                 110

 caa aga tac cct gag ata aga ttt ttt ccc cca aaa tca aat aaa gct     1101
 Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro Pro Lys Ser Asn Lys Ala
         115                 120                 125

 tat cag tat cac agt tac aat ggt tgg aat agg gat gct tat tcc ctg     1149
 Tyr Gln Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp Ala Tyr Ser Leu
     130                 135                 140

 aga atc tgg ggt cta gga ttt tta cct caa gta tcc aca gat cta aca     1197
 Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln Val Ser Thr Asp Leu Thr
 145                 150                 155                 160

 cct cag act ttc agt gaa aaa gtt cta caa ggg aaa aat cat tgg gtg     1245
 Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys Asn His Trp Val
                 165                 170                 175

 att gat ttc tat gct cct tgg tgt gga cct tgc cag aat ttt gct cca     1293
 Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln Asn Phe Ala Pro
             180                 185                 190

 gaa ttt gag ctc ttg gct agg atg att aaa gga aaa gtg aaa gct gga     1341
 Glu Phe Glu Leu Leu Ala Arg Met Ile Lys Gly Lys Val Lys Ala Gly
         195                 200                 205

 aaa gta gac tgt cag gct tat gct cag aca tgc cag aaa gct ggg atc     1389
 Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr Cys Gln Lys Ala Gly Ile
     210                 215                 220

 agg gcc tat cca act gtt aag ttt tat ttc tac gaa aga gca aag aga     1437
 Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe Tyr Glu Arg Ala Lys Arg
 225                 230                 235                 240

 aat ttt caa gaa gag cag ata aat acc aga gat gca aaa gca atc gct     1485
 Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg Asp Ala Lys Ala Ile Ala
                 245                 250                 255

 gcc tta ata agt gaa aaa ttg gaa act ctc cga aat caa ggc aag agg     1533
 Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu Arg Asn Gln Gly Lys Arg
             260                 265                 270

 aat aag gat gaa ctt tga taatgt tgaagatgaa gaaaaagttt aaaagaaatt     1587
 Asn Lys Asp Glu Leu 
         275

 ctgacagatg a                                                        1598




      <210> 154
      <211> 1901
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (627)..(1442)

      <400> 154
 tccgaaaggc cagtgtctta tctctccact tcaagtccag aggacttgct cagtctcctc     60

 cccttaagtc atttccacca tcctcaggca gctgtgggaa gccgagagtc ctggactgtt    120

 cgtccgggtg ccagcgctgg cagtcccagt ccgtccggtg cagcagcccg gcgcattccc    180

 ctctctccct ccctcttgct ctccctccct ttctgtcttc ctctctttcc tcctctactg    240

 ctccctccct ctcttgcctc ttaagtttcc tgcaccgtga atccaactgt gccaagcctt    300

 ggctcccgcg aaccaatcct gagcgcgacc cgggcactgg gacggcgact ccgccaaagc    360

 tggacgaggc agccggaccc gtctgcgctc gagcatggag acggagcgcc tgggagggca    420

 cgtccggggc gctggagacg ccaggcccga gtagcttctc catggagcct gcccagagcg    480

 gtcccttctc gcaggattcg ccccaagtcc tgtgcggctg ctgagagcgc tccttgctct    540

 gtaaagtgga tgtcaggtgg atctatgttt ctgaaggaac aaagactcaa agaaggcacc    600

 gccaaggaag tttgagacgc gggaga atg cag gct gcg tgc tgg tac gtg ctt     653
                              Met Gln Ala Ala Cys Trp Tyr Val Leu
                                1               5

 ttc ctc ctg cag ccc acc gtc tac ttg gtc aca tgt gcc aat tta acg      701
 Phe Leu Leu Gln Pro Thr Val Tyr Leu Val Thr Cys Ala Asn Leu Thr
  10                  15                  20                  25

 aac ggt gga aag tca gaa ctt ctg aaa tca gga agc agc aaa tcc aca      749
 Asn Gly Gly Lys Ser Glu Leu Leu Lys Ser Gly Ser Ser Lys Ser Thr
                  30                  35                  40

 cta aag cac ata tgg aca gaa agc agc aaa gac ttg tct atc agc cga      797
 Leu Lys His Ile Trp Thr Glu Ser Ser Lys Asp Leu Ser Ile Ser Arg
              45                  50                  55

 ctc ctg tca cag act ttt cgt ggc aaa gag aat gat aca gat ttg gac      845
 Leu Leu Ser Gln Thr Phe Arg Gly Lys Glu Asn Asp Thr Asp Leu Asp
          60                  65                  70

 ctg aga tat gac acc cca gaa cct tat tct gag caa gac ctc tgg gac      893
 Leu Arg Tyr Asp Thr Pro Glu Pro Tyr Ser Glu Gln Asp Leu Trp Asp
      75                  80                  85

 tgg ctg agg aac tcc aca gac ctt caa gag cct cgg ccc agg gcc aag      941
 Trp Leu Arg Asn Ser Thr Asp Leu Gln Glu Pro Arg Pro Arg Ala Lys
  90                  95                 100                 105

 aga agg ccc att gtt aaa acg ggc aag ttt aag aaa atg ttt gga tgg      989
 Arg Arg Pro Ile Val Lys Thr Gly Lys Phe Lys Lys Met Phe Gly Trp
                 110                 115                 120

 ggc gat ttt cat tcc aac atc aaa aca gtg aag ctg aac ctg ttg ata     1037
 Gly Asp Phe His Ser Asn Ile Lys Thr Val Lys Leu Asn Leu Leu Ile
             125                 130                 135

 act ggg aaa att gta gat cat ggc aat ggg aca ttt agt gtt tat ttc     1085
 Thr Gly Lys Ile Val Asp His Gly Asn Gly Thr Phe Ser Val Tyr Phe
         140                 145                 150

 agg cat aat tca act ggt caa ggg aat gta tct gtc agc ttg gta ccc     1133
 Arg His Asn Ser Thr Gly Gln Gly Asn Val Ser Val Ser Leu Val Pro
     155                 160                 165

 cct aca aaa atc gtg gaa ttt gac ttg gca caa caa acc gtg att gat     1181
 Pro Thr Lys Ile Val Glu Phe Asp Leu Ala Gln Gln Thr Val Ile Asp
 170                 175                 180                 185

 gcc aaa gat tcc aag tct ttt aat tgt cgc att gaa tat gaa aag gtt     1229
 Ala Lys Asp Ser Lys Ser Phe Asn Cys Arg Ile Glu Tyr Glu Lys Val
                 190                 195                 200

 gac aag gct acc aag aac aca ctc tgc aac tat gac cct tca aaa acc     1277
 Asp Lys Ala Thr Lys Asn Thr Leu Cys Asn Tyr Asp Pro Ser Lys Thr
             205                 210                 215

 tgt tac cag gag caa acc caa agt cat gta tcc tgg ctc tgc tcc aag     1325
 Cys Tyr Gln Glu Gln Thr Gln Ser His Val Ser Trp Leu Cys Ser Lys
         220                 225                 230

 ccc ttt aag gtg atc tgt att tac att tcc ttt tat agt aca gat tat     1373
 Pro Phe Lys Val Ile Cys Ile Tyr Ile Ser Phe Tyr Ser Thr Asp Tyr
     235                 240                 245

 aaa ctg gta cag aaa gtg tgc cct gac tac aac tac cac agt gac aca     1421
 Lys Leu Val Gln Lys Val Cys Pro Asp Tyr Asn Tyr His Ser Asp Thr
 250                 255                 260                 265

 cct tac ttt ccc tcg gga tga ag gtgaacatgg gggtgagact gaagcctgag     1474
 Pro Tyr Phe Pro Ser Gly 
                 270

 gaattaaagg tcatatgaca gggctgttac ctcaaagaag aaggtcacat ctgttgcctg   1534

 gaatgtgtct acactgctgc tcttgtcaac tggctgcaaa atacactagt ggaaaacact   1594

 ctgatgtaat ttctgcccag tcagcttcat ccctcagtat aattgtaaat catcacagat   1654

 tttgaagtca cacctgaaga catgctctca catatagagg tacacaaaca caccgtcatg   1714

 cacatttcag cttgcgtcta tcatgattca tgttgagagg gctttcattg tctgactcat   1774

 aatggttcag gatcaactat catcgaacgg aaggattata tagacagaga atgtttctca   1834

 cagttgctga aatggaaatc tcttttaaag taaagagtac atgataatca ataatctcca   1894

 ctcatgc                                                             1901




      <210> 155
      <211> 1763
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (745)..(906)

      <400> 155
 gcccgcacat tcccgggtcg acgatatcgt ccgggtcact gccgctgact gctggatgtg     60

 ccagcctgtg gccaggggct ttgtggtcct ccccatcaca gagttcctcg tgggggacct    120

 tgttgtcacc cagaacactt ccctaccctg gcccagctcc tatctcacta agaccgtcct    180

 gaaagtctcc ttcctcctcc acgacccgag caacttcctc aagaccgcct tgtttctcta    240

 cagctgggac ttcggggacg ggacccagat ggtgactgaa gactccgtgg tctattataa    300

 ctattccatc atcgggacct tcaccgtgaa gctcaaagtg gtggcggagt gggaagaggt    360

 ggagccggat gccacgaggg ctgtgaagca gaagaccggg gacttctccg cctcgctgaa    420

 gctgcaggaa acccttcgag gcatccaagt gttggggccc accctaattc agaccttcca    480

 aaagatgacc gtgaccttga acttcctggg gagccctcct ctgactgtgt gctggcgtct    540

 caagcctgag tgcctcccgc tggaggaagg ggagtgccac cctgtgtccg tggccagcac    600

 agcgtacaac ctgacccaca ccttcaggga ccctggggac tactgcttca gcatccgggc    660

 cgagaatatc atcagcaaga cacatcagta ccacaagatc caggtgtggc cctccagaat    720

 ccagccggct gtctttgctt tccc   atg tgc tac act tat cac tgt gat gtt     771
                              Met Cys Tyr Thr Tyr His Cys Asp Val
                                1               5

 ggc ctt cat cat gta cat gac cct gcg gaa tgc cac tca gca aaa gga      819
 Gly Leu His His Val His Asp Pro Ala Glu Cys His Ser Ala Lys Gly
  10                  15                  20                  25

 cat ggt gga gaa ccc gga gcc acc ctc tgg ggt cag gtg ctg ctg cca      867
 His Gly Gly Glu Pro Gly Ala Thr Leu Trp Gly Gln Val Leu Leu Pro
                  30                  35                  40

 gat gtg ctg tgg gcc ttt ctt gct gga gac tcc atc tga gtacctggaa       916
 Asp Val Leu Trp Ala Phe Leu Ala Gly Asp Ser Ile 
              45                  50

 attgttcgtg agaaccacgg gctgctcccg cccctctata agtctgtcaa aacttacacc    976

 gtgtgagcac tccccctccc caccccatct cagtgttaac tgactgctga cttggagttt   1036

 ccagcagggt ggtgtgcacc actgaccagg aggggttcat ttgcgtgggg ctgttggcct   1096

 ggatcatcca tccatctgta cagttcagcc actgccacaa gcccctccct ctctgtcacc   1156

 cctgacccca gccattcacc catctgtaca gtccagccac tgacataagc cccactcggt   1216

 taccaccccc ttgaccccct acctttgaag aggcttcgtg caggactttg atgcttgggg   1276

 tgttccgtgt tgactcccag gtgggcctgg ctgcccactg cccattcctc tcatattggc   1336

 acatctgctg tccattgggg gttctcagtt tcctccccca gacagcccta cctgtgccag   1396

 agagctagaa agaaggtcat aaagggttaa aaatccataa ctaaaggttg tacacataga   1456

 tgggcacact cacagagaga agtgtgcatg tacacacacc acacacacac acacacacac   1516

 acacagagaa atataaacac atgcgtcaca tgggcatttc agatgatcag ctctgtatct   1576

 ggttaagtcg ggtgctggga tgcaccctgc actagagctg aaaggaaatt tgacctccaa   1636

 gcagccctga caggttctgg gcccgggccc tccctttgtg ctttgtctct gcagttcttg   1696

 cgccctttat aaggccatcc tagtccctgc tggctggcag ggggctggat ggggggcagg   1756

 actaatt                                                             1763




      <210> 156
      <211> 1207
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (325)..(1110)

      <400> 156
 ttgccgttcg cctgacgtac cggtccggaa ttcccgggtc gacgatttcg tcccactccc     60

 gcggggctat tgtccccggt aaactgcagt ttctggttcg agactccaat cctgtttcga    120

 attgctgctt gctgcccctt gggctgggga taatggaagt tctttccctt cccaactctt    180

 tccagaccca agcactctgg gactcactcc atagtccagg agttccaggt tccggattat    240

 gttccatggc agcagtccaa gcaggaaacc aagccatcta ctctgcctcc agtccaacaa    300

 gccaacagcc ttcatacaag caaa   atg aag act ttg act agg gtc caa cca     351
                              Met Lys Thr Leu Thr Arg Val Gln Pro
                                1               5

 gtg ttt cac ttc aag ccc act acg gtg gtg aca agc tgc cag ccg aag      399
 Val Phe His Phe Lys Pro Thr Thr Val Val Thr Ser Cys Gln Pro Lys
  10                  15                  20                  25

 aat cca aga gaa cta cat aga agg cgg aag ttg gac cct ggg aag atg      447
 Asn Pro Arg Glu Leu His Arg Arg Arg Lys Leu Asp Pro Gly Lys Met
                  30                  35                  40

 cat gcc aaa atc tgg tta atg aag acg tcg ctc agg agc ggg agg gcc      495
 His Ala Lys Ile Trp Leu Met Lys Thr Ser Leu Arg Ser Gly Arg Ala
              45                  50                  55

 gct ctg cga gag ctc cga agc cgt gag aac ttc ctc agc aag ctc aac      543
 Ala Leu Arg Glu Leu Arg Ser Arg Glu Asn Phe Leu Ser Lys Leu Asn
          60                  65                  70

 cgg gag ctg atc gag acc atc cag gag atg gag aac agc acg acc ctg      591
 Arg Glu Leu Ile Glu Thr Ile Gln Glu Met Glu Asn Ser Thr Thr Leu
      75                  80                  85

 cac gtg cgg gcc ctg ctg cag cag cag gac acc ttg gcg acc atc atc      639
 His Val Arg Ala Leu Leu Gln Gln Gln Asp Thr Leu Ala Thr Ile Ile
  90                  95                 100                 105

 gac atc ttg gag tac tca aac aag aag agg ctg cag caa ttg aaa tct      687
 Asp Ile Leu Glu Tyr Ser Asn Lys Lys Arg Leu Gln Gln Leu Lys Ser
                 110                 115                 120

 gag ctt cag gag tgg gaa gaa aag aag aaa tgc aag atg agc tat ctt      735
 Glu Leu Gln Glu Trp Glu Glu Lys Lys Lys Cys Lys Met Ser Tyr Leu
             125                 130                 135

 gag cag cag gca gag cag ctg aat gcc aag att gag aag acc cag gag      783
 Glu Gln Gln Ala Glu Gln Leu Asn Ala Lys Ile Glu Lys Thr Gln Glu
         140                 145                 150

 gaa gtg aac ttc ctg agc act tac atg gac cat gag tat tcc atc aag      831
 Glu Val Asn Phe Leu Ser Thr Tyr Met Asp His Glu Tyr Ser Ile Lys
     155                 160                 165

 tct gtc cag atc tcc act ctt atg cgc cag ctg cag cag gtt aag gac      879
 Ser Val Gln Ile Ser Thr Leu Met Arg Gln Leu Gln Gln Val Lys Asp
 170                 175                 180                 185

 agc cag cag gat gag ctg gat gac ctc ggt gag atg cgc aca aag gtc      927
 Ser Gln Gln Asp Glu Leu Asp Asp Leu Gly Glu Met Arg Thr Lys Val
                 190                 195                 200

 ctg gaa tcc ttg tct gac aag att cag aag aag aag aaa aaa att ctg      975
 Leu Glu Ser Leu Ser Asp Lys Ile Gln Lys Lys Lys Lys Lys Ile Leu
             205                 210                 215

 agt tct gtg gtg gcg gaa acc cag cgt ccc tat gaa gag gct ctc cta     1023
 Ser Ser Val Val Ala Glu Thr Gln Arg Pro Tyr Glu Glu Ala Leu Leu
         220                 225                 230

 cag aag atg tgg gaa agc cag gac ttc ctg aaa tgc atg caa agg ttc     1071
 Gln Lys Met Trp Glu Ser Gln Asp Phe Leu Lys Cys Met Gln Arg Phe
     235                 240                 245

 aga gaa gtg cgt ggg caa gga agg tgg tgg tcc ctg tag ggaagcagtg      1120
 Arg Glu Val Arg Gly Gln Gly Arg Trp Trp Ser Leu 
 250                 255                 260

 gatgggcagt ccccacggcc tgtgggaatg agtcaggctt ctcctgatct ggcgctcaag   1180

 aggtctctga ctctggtgtt ggcctcc                                       1207




      <210> 157
      <211> 1324
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(1155)

      <400> 157
 aggggcagcg acgcggaaga tgactcaggg cccactttga acctcctggg tacttgagca     60

 agctcaaggg tgttcggacc tctagggaga cgttgcatca cgcagtttgg aaagaacttg    120

 ggaattctcc ctggggggct cgctgtattt actgggaact agtcttgcag gaaggcttat    180

 gtacagaagt acgtcgtgaa gaattatttc tactattacc tattccaatt ttcagctgct    240

 ttgggccaag aagtgttcta catcacgttt cttccattca ctcactggaa tattgaccct    300

 tatttatcca gaagattgat catcatatgg gttttggtg   atg tat att ggc caa     354
                                              Met Tyr Ile Gly Gln
                                                1               5

 gtg gcc aag gat gtc ttg aag tgg ccc cgt ccc tcc tcc cct cca gtt      402
 Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro Ser Ser Pro Pro Val
                  10                  15                  20

 gta aaa ctg gaa aag aga ctg atc gct gaa tat gga atg cca tcc acc      450
 Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr Gly Met Pro Ser Thr
              25                  30                  35

 cac gcc atg gcg gcc act gcc att gcc ttc acc ctc ctt atc tct act      498
 His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr Leu Leu Ile Ser Thr
          40                  45                  50

 atg gac aga tac cag tat cca ttt gtg ttg gga ctg gtg atg gcc gtg      546
 Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly Leu Val Met Ala Val
      55                  60                  65

 gtg ttt tcc acc ttg gtg tgt ctc agc agg ctc tac act ggg atg cat      594
 Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu Tyr Thr Gly Met His
  70                  75                  80                  85

 acg gtc ctg gat gtg ctg ggt ggc gtc ctg atc acc gca ctc ctc atc      642
 Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile Thr Ala Leu Leu Ile
                  90                  95                 100

 gtc ctc acc tac cct gcc tgg acc ttc atc gac tgc ctg gac tcg gcc      690
 Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp Cys Leu Asp Ser Ala
             105                 110                 115

 agc ccc ctc ttc ccc gtg tgt gtc ata gtt gtg cca ttc ttc ctg tgt      738
 Ser Pro Leu Phe Pro Val Cys Val Ile Val Val Pro Phe Phe Leu Cys
         120                 125                 130

 tac aat tac cct gtt tct gat tac tac agc cca acc cgg gcg gac acc      786
 Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro Thr Arg Ala Asp Thr
     135                 140                 145

 acc acc att ctg gct gcc ggg gct gga gtg acc ata gga ttc tgg atc      834
 Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr Ile Gly Phe Trp Ile
 150                 155                 160                 165

 aac cat ttc ttc cag ctt gta tcc aag ccc gct gaa tct ctc cct gtt      882
 Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala Glu Ser Leu Pro Val
                 170                 175                 180

 att cag aac atc cca ccg ctc acc acc tac atg tta gtt ttg ggt ctg      930
 Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met Leu Val Leu Gly Leu
             185                 190                 195

 acc aaa ttt gca gtg gga att gtg ttg atc ctc ttg gtt cgt cag ctt      978
 Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu Leu Val Arg Gln Leu
         200                 205                 210

 gta caa aat ctc tca ctg caa gta tta tac tca tgg ttc aag gtg gtc     1026
 Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser Trp Phe Lys Val Val
     215                 220                 225

 acc agg aac aag gag gcc agg cgg aga ctg gag att gaa gtg cct tac     1074
 Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu Ile Glu Val Pro Tyr
 230                 235                 240                 245

 aag ttt gtt acc tac aca tct gtt ggc atc tgc gct aca acc ttt gtg     1122
 Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Cys Ala Thr Thr Phe Val
                 250                 255                 260

 ccg atg ctt cac agg ttt ctg gga tta ccc tga gtctcaaa cagttggaaa     1173
 Pro Met Leu His Arg Phe Leu Gly Leu Pro 
             265                 270

 ctagcccact ggacatgaaa gccaagacat aggaaagtta ttggtaggca aatcttgaca   1233

 acttattttt ctttaacaac aacaaaaagt catacggctg tcttgctact accagataaa   1293

 tgatgctgct gtgtgaaagg aaaaaaaaaa a                                  1324




      <210> 158
      <211> 1399
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(553)

      <400> 158
 gcgaggctgc tgaaaccgaa accgctgtgc tgtgggcgca gcgccgagat tgattcacct     60

 tcacctgtgc tgcactccag ctgacccaag taggaagcca gacgagctgt aaaac atg     118
                                                              Met
                                                                1

 aac gga aga gtg gat tat ttg gtc act gag gaa gag atc aat ctt acc      166
 Asn Gly Arg Val Asp Tyr Leu Val Thr Glu Glu Glu Ile Asn Leu Thr
               5                  10                  15

 aga ggg ccc tca ggg ctg ggc ttc aac atc gtc ggt ggg aca gat cag      214
 Arg Gly Pro Ser Gly Leu Gly Phe Asn Ile Val Gly Gly Thr Asp Gln
          20                  25                  30

 cag tat gtc tcc aac gac agt ggc atc tac gtc agc cgc atc aaa gaa      262
 Gln Tyr Val Ser Asn Asp Ser Gly Ile Tyr Val Ser Arg Ile Lys Glu
      35                  40                  45

 aat ggg gct gcg gcc ctg gat ggg cgg ctc cag gag ggt gat aag atc      310
 Asn Gly Ala Ala Ala Leu Asp Gly Arg Leu Gln Glu Gly Asp Lys Ile
  50                  55                  60                  65

 ctt tcg gta aat ggc caa gac cta aag aac ctg ctg cac cag gat gct      358
 Leu Ser Val Asn Gly Gln Asp Leu Lys Asn Leu Leu His Gln Asp Ala
                  70                  75                  80

 gta gac ctc ttt cgt aat gca ggc tat gct gtg tct ctg aga gtg cag      406
 Val Asp Leu Phe Arg Asn Ala Gly Tyr Ala Val Ser Leu Arg Val Gln
              85                  90                  95

 cac agg tta cag gtg cag aat gga cct ata gga cat cga ggt gaa ggg      454
 His Arg Leu Gln Val Gln Asn Gly Pro Ile Gly His Arg Gly Glu Gly
         100                 105                 110

 gac cca agt ggt att ccc ata ttt atg gtg ctg gtg cca gtg ttt gcc      502
 Asp Pro Ser Gly Ile Pro Ile Phe Met Val Leu Val Pro Val Phe Ala
     115                 120                 125

 ctc acc atg gta gca gcc tgg gct ttc atg aga tac cgg caa caa ctt      550
 Leu Thr Met Val Ala Ala Trp Ala Phe Met Arg Tyr Arg Gln Gln Leu
 130                 135                 140                 145

 tga aaaa cttgctctct ttcaatactc ccaatgaaga tacatttcac tcaccctcca      607
 


 cccctgctat tctgccatgt ctttccctct ctctgcatag ccagatttga agtgactgat    667

 acccacccca aaccttgctg ttcacagtct ccaattcttc atattctaat gggaaagtaa    727

 aggtattgtt tgaaggaaaa ctgaagaaaa gacttggctt agaacaaatg aggagttata    787

 tattttacta ggacttttga tagaaattca gctacaaccc aaagagagaa agattgagtc    847

 ttcctgtcac cataggcaat accttttttc ttagctggca tgccataaag gccagctatg    907

 tgatattaga ggaagaaagg atttttcttt ttaatgatct tccttgggaa attattgtgg    967

 cctttattta atttctaact acgtacctgg gtgcctatat cgacaaagag tgagaagagc   1027

 atttttactt ttttaaaaaa gcaaatacat atatacacat acgtatgcaa atattatagt   1087

 ataatagtga tccctatgga gaattaaagg tgagaaagct actttgtggt gtctaggttt   1147

 ctgataaaag ggatgatctt aactgaagaa tttaaagaga tacttaaaca gagcaaatgt   1207

 agtaggaaca agggagtgag ccttataaga ggacgttcag tctcatttat taaaataata   1267

 actgagactg ggagaggtgg ctcatgcctg taaatcccag cactttggta gcctgaagtg   1327

 ggagattgct tgagtccagg agaccagcct gggcaacata gcaaaacctc atctctattt   1387

 aaaaaaaaaa aa                                                       1399




      <210> 159
      <211> 965
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(423)

      <400> 159
 gatatttgcg tcttttgccc acccccctgg cattcagctg gacccaacta ggccatc        57                                                                 
 atg agt ggc ttc tcc ctg tca tcc cca ggg gtc ata gga tat cta cac      105
 Met Ser Gly Phe Ser Leu Ser Ser Pro Gly Val Ile Gly Tyr Leu His
   1               5                  10                  15

 cgc ctt tct gac ccc acc ctg cac tcc cat cct ttc ctc tct ccc cgt      153
 Arg Leu Ser Asp Pro Thr Leu His Ser His Pro Phe Leu Ser Pro Arg
              20                  25                  30

 tca tgc cct gca cta cat agc aca gcc ggg atg ctt gga aca gag gcc      201
 Ser Cys Pro Ala Leu His Ser Thr Ala Gly Met Leu Gly Thr Glu Ala
          35                  40                  45

 ttg gct gct ccg cag tgc aca ggg ctt ccc tct ctc ggg gtt ggc ttc      249
 Leu Ala Ala Pro Gln Cys Thr Gly Leu Pro Ser Leu Gly Val Gly Phe
      50                  55                  60

 ttc cca ggc ctt gca tgg gcc ctg ccc aca agc aca ccc tca ggc cga      297
 Phe Pro Gly Leu Ala Trp Ala Leu Pro Thr Ser Thr Pro Ser Gly Arg
  65                  70                  75                  80

 ggg tgc aga ctg atg ctc ttc cct gat gga gac cct gag atc ttc ccc      345
 Gly Cys Arg Leu Met Leu Phe Pro Asp Gly Asp Pro Glu Ile Phe Pro
                  85                  90                  95

 acc ccc aat cat gat gtc ttc agt gtg gga ctg ggg tcc tct tgg ttc      393
 Thr Pro Asn His Asp Val Phe Ser Val Gly Leu Gly Ser Ser Trp Phe
             100                 105                 110

 tgc ctg cag cct gcc tgg ctc cgc ccc tag t gccccctcct caccacactg      444
 Cys Leu Gln Pro Ala Trp Leu Arg Pro 
         115                 120

 gccccaggtc tcaggagggg tgtcctgggc agggaaggtc agtgtcactg atggtttgct    504

 gtttggaagc cattggcagg gctgccgtgc atgtggctgt gagggctgca cagtcctgcc    564

 aaggggcttc ctccttgtca ccccgaacct tgtaatcgtg tgctggcgtg gcagccctgg    624

 ctaagttaat ccccaccgct ttcagtggta gaaagaattc cctgagtggg ccaggctggt    684

 gccctcctcc taccctggct tttctgagtg agctgcctgg agccctcatc ccctctccca    744

 ggctgggctg gccctgggcg gggccactgt gtgctggccc actgtgacct gacccgacct    804

 tgtgcagccc ccctgccctg gtgtcctggg ttttcgtgat gatctttgct ctgtttccag    864

 tggggtttga agcagagttc agggaaccct gcccaaggtc ctcctgttca gacattccta    924

 tgttgaataa agtatgtttg acttccccgg aaaaaaaaaa a                        965




      <210> 160
      <211> 4773
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4689)

      <400> 160
  atg cct ggg gag gct gcc cgc gcc gag ctg ctg ctg ccc gag gcg gac      48
  Met Pro Gly Glu Ala Ala Arg Ala Glu Leu Leu Leu Pro Glu Ala Asp
    1               5                  10                  15

 cga ccc ggg ccc cgc aca gat ctg tcc tgc gat gcg gcc gct gcc acc       96
 Arg Pro Gly Pro Arg Thr Asp Leu Ser Cys Asp Ala Ala Ala Ala Thr
              20                  25                  30

 acc atc ctg gga ggg gac cgg cgg gag ccc tgt gct ctg acc cca ggg      144
 Thr Ile Leu Gly Gly Asp Arg Arg Glu Pro Cys Ala Leu Thr Pro Gly
          35                  40                  45

 ccc agc cac ctg gcc ctc acg ttc ctg ccc agc aag ccg ggt gcc cgg      192
 Pro Ser His Leu Ala Leu Thr Phe Leu Pro Ser Lys Pro Gly Ala Arg
      50                  55                  60

 ccc cag ccc gag gga gcc agc tgg gat gca ggg cct ggt ggg gca ccc      240
 Pro Gln Pro Glu Gly Ala Ser Trp Asp Ala Gly Pro Gly Gly Ala Pro
  65                  70                  75                  80

 tcg gcc tgg gcg gac cca ggg gag ggc ggc cca agc ccc atg ctc ctc      288
 Ser Ala Trp Ala Asp Pro Gly Glu Gly Gly Pro Ser Pro Met Leu Leu
                  85                  90                  95

 cct gag ggc ctg tct tcc cag gct ctg tcc acg gag gct cct ctc ccg      336
 Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr Glu Ala Pro Leu Pro
             100                 105                 110

 gcc acc ctg gag ccc cgg att gtg atg gga gag gag acg tgc cag gcc      384
 Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu Glu Thr Cys Gln Ala
         115                 120                 125

 ctc ctg tca ccc aga gct gcc cgg aca gcg ctc agg gac cag gag ggt      432
 Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu Arg Asp Gln Glu Gly
     130                 135                 140

 ggg cac gca agc cca gac cca ccc ccc gag ctg tgt tct cag ggt gat      480
 Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu Cys Ser Gln Gly Asp
 145                 150                 155                 160

 ctt tct gtg cct tcc cct ccc cca gac cct gat tcc ttc ttc acg cct      528
 Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp Ser Phe Phe Thr Pro
                 165                 170                 175

 ccc tcc acc ccc acc aag acc acc tat gcc ctg ctt cct gcc tgt ggg      576
 Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu Leu Pro Ala Cys Gly
             180                 185                 190

 ccc cac ggg gac gcc agg gac tca gag gct gag ctg cgg gat gag ctg      624
 Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu Leu Arg Asp Glu Leu
         195                 200                 205

 ctg gac tcg ccc ccc gcc tca ccc tcg ggc tcc tac att acg gcc gat      672
 Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser Tyr Ile Thr Ala Asp
     210                 215                 220

 ggg gac agc tgg gcc tct tca ccc tcc tgt tcc ctc agc ctg ctg gct      720
 Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser Leu Ser Leu Leu Ala
 225                 230                 235                 240

 ccg gct gaa ggg ctg gac ttc ccc tca ggc tgg ggc ctg tcc ccg cag      768
 Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp Gly Leu Ser Pro Gln
                 245                 250                 255

 ggg tcc atg gtg gat gaa cga gag ctg cac cca gca ggg acc cca gag      816
 Gly Ser Met Val Asp Glu Arg Glu Leu His Pro Ala Gly Thr Pro Glu
             260                 265                 270

 ccc ccg tcc tct gag tcc agc ctc tct gca gac agc agc tcc tcc tgg      864
 Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp Ser Ser Ser Ser Trp
         275                 280                 285

 ggc cag gag ggc cac ttc ttc gac ctg gac ttc ctg gcc aat gac cca      912
 Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe Leu Ala Asn Asp Pro
     290                 295                 300

 atg atc ccc gca gcc ctc cta ccc ttc cag ggc agc ctc atc ttt cag      960
 Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly Ser Leu Ile Phe Gln
 305                 310                 315                 320

 gtg gag gca gtg gag gtg aca ccg cta tcc cca gag gaa gaa gaa gag     1008
 Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro Glu Glu Glu Glu Glu
                 325                 330                 335

 gag gct gtg gcg gat ccc gac cca ggt ggg gac ctg gct ggg gag ggt     1056
 Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp Leu Ala Gly Glu Gly
             340                 345                 350

 gag gag gac agc acg tct gcc tcc ttc ctg cag tca ctg tct gac ctg     1104
 Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln Ser Leu Ser Asp Leu
         355                 360                 365

 tcc atc acg gag ggc atg gac gag gct ttt gcc ttc cgg gac gac acc     1152
 Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala Phe Arg Asp Asp Thr
     370                 375                 380

 tct gca gcc tcc tct gat tca gac tca gcc tcc tac gca gag gca gat     1200
 Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser Tyr Ala Glu Ala Asp
 385                 390                 395                 400

 gat gag agg ctg tac agc ggg gag ccc cat gcc cag gcc act ttg ctc     1248
 Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala Gln Ala Thr Leu Leu
                 405                 410                 415

 cag gac agt gtc cag aag aca gag gag gag agc gga ggt ggg gcc aag     1296
 Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser Gly Gly Gly Ala Lys
             420                 425                 430

 ggg ctg cag gct cag gat ggg act gtg tcc tgg gcc gtg gag gct gct     1344
 Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp Ala Val Glu Ala Ala
         435                 440                 445

 cct cag acc tca gac aga ggg gcc tat ctg tcc cag aga cag gaa ttg     1392
 Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser Gln Arg Gln Glu Leu
     450                 455                 460

 atc tca gaa gta aca gaa gag ggc ctt gct tta ggc cag gag tcc act     1440
 Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu Gly Gln Glu Ser Thr
 465                 470                 475                 480

 gcc act gtg acc cct cac act ctg cag gta gcc cca ggc ctc cag gtg     1488
 Ala Thr Val Thr Pro His Thr Leu Gln Val Ala Pro Gly Leu Gln Val
                 485                 490                 495

 gag gtg gct acc aga gtg acc cca cag gct ggg gag gaa gaa aca gac     1536
 Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly Glu Glu Glu Thr Asp
             500                 505                 510

 tcc acc gct gga caa gaa tct gct gcc atg gca atg cct cag ccc tcc     1584
 Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala Met Pro Gln Pro Ser
         515                 520                 525

 cag gag ggc atc agc gag atc tta ggc caa gag tct gtc act gca gaa     1632
 Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu Ser Val Thr Ala Glu
     530                 535                 540

 aaa ctt cca act cca cag gaa gaa aca agc ctc aca ttg tgt cca gac     1680
 Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu Thr Leu Cys Pro Asp
 545                 550                 555                 560

 tct cct cag aac ttg aag gaa gaa gga ggg ctg gac ctc ccc tct ggc     1728
 Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu Asp Leu Pro Ser Gly
                 565                 570                 575

 aga aag cct gta gct gca gcc acg att gtc ccc agg cag gct gaa gag     1776
 Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro Arg Gln Ala Glu Glu
             580                 585                 590

 gac ctc acc tta ccc cag gac tcc gct atg aca ccg cct ctg ccc cta     1824
 Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         595                 600                 605

 caa gac aca gat ctc tca tca gcc cca aag cct gtg gct gca gcc acg     1872
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     610                 615                 620

 att gtg tcc cag cag gct gaa gag ggc ctc acc tta ccc cag gac tcc     1920
 Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 625                 630                 635                 640

 gtt atg aca ccg cct ctg ccc cta caa gac aca gat ctc tcg tca gcc     1968
 Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 645                 650                 655

 cca aag cct gtg gct gca gcc acg ctt gtg tcc cag cag gct gaa gag     2016
 Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu
             660                 665                 670

 ggc ctc acc tta ccc cag gac tcc gct atg aca ccg cct ctg ccc cta     2064
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         675                 680                 685

 caa gac aca gat ctc tcg tca gcc cca aag cct gtg gct gca gcc acg     2112
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     690                 695                 700

 ctt gtg tcc cag cag gct gaa gag ggc ctc acc tta ccc cag gac tcc     2160
 Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 705                 710                 715                 720

 gct atg aca ccg cct ctg ccc cta caa gac aca gat ctc tcg tca gcc     2208
 Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 725                 730                 735

 cca aag cct gtg gct gca gcc acg ctt gtg tcc cag cag gct gaa gag     2256
 Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu
             740                 745                 750

 ggc ctc acc tta ccc cag gac tcc gct atg aca ccg cct ctg ccc cta     2304
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         755                 760                 765

 caa gac aca gat ctc tcg tca gcc cca aag cct gtg gct gca gcc acg     2352
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     770                 775                 780

 att gtg tcc cag cag gct gaa gag ggc ctc acc tta ccc cag gac tcc     2400
 Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 785                 790                 795                 800

 gct atg aca ccg cct ctg ccc cta caa gac aca gat ctc tcg tca gcc     2448
 Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 805                 810                 815

 cca aag cct gtg gct gca gcc acg att gtg tcc cag cag gct gaa gag     2496
 Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu
             820                 825                 830

 ggc ctc acc tta ccc cag gac tcc gct atg aca ccg cct ctg ccc cta     2544
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         835                 840                 845

 caa gac aca gat ctc tcg tca gcc cca aag cct gtg gct gca gcc acg     2592
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     850                 855                 860

 cct gtg tcc cag cag gct gaa gag ggc ctc acc tta ccc cag gac tcc     2640
 Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 865                 870                 875                 880

 gct atg aca ccg cct ctg ccc cta caa gac aca gat ctc tcg tca gcc     2688
 Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 885                 890                 895

 cca aag cct gtg gct gca gcc acg cct gtg tcc cag cag gct gaa gag     2736
 Pro Lys Pro Val Ala Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu
             900                 905                 910

 ggc ctc acc tta ccc cag gac tcc gct atg aca gca cct ctg cct ctg     2784
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Ala Pro Leu Pro Leu
         915                 920                 925

 caa gac aca ggc ccc acc tca ggt cca gag cct ctg gct gtg gcc acc     2832
 Gln Asp Thr Gly Pro Thr Ser Gly Pro Glu Pro Leu Ala Val Ala Thr
     930                 935                 940

 cct caa acc ttg cag gca gaa gca ggc tgt gcc cca ggg aca gag cct     2880
 Pro Gln Thr Leu Gln Ala Glu Ala Gly Cys Ala Pro Gly Thr Glu Pro
 945                 950                 955                 960

 gtg gcc acc atg gct cag cag gaa gta ggt gag gcc tta ggc ccc agg     2928
 Val Ala Thr Met Ala Gln Gln Glu Val Gly Glu Ala Leu Gly Pro Arg
                 965                 970                 975

 cca gca cct gag gag aag aat gca gcc ctc cct aca gtc ccg gag cct     2976
 Pro Ala Pro Glu Glu Lys Asn Ala Ala Leu Pro Thr Val Pro Glu Pro
             980                 985                 990

 gca gcc ttg gac cag gtc caa cag gat gac cca cag cca gct gca gaa     3024
 Ala Ala Leu Asp Gln Val Gln Gln Asp Asp Pro Gln Pro Ala Ala Glu
         995                1000                1005

 gct ggg aca cct tgg gcc gca cag gaa gat gcg gat tcc act ttg ggc     3072
 Ala Gly Thr Pro Trp Ala Ala Gln Glu Asp Ala Asp Ser Thr Leu Gly
    1010                1015                1020

 atg gag gcc ctc agt ctc cct gag ccg gcc tct ggt gct ggg gag gaa     3120
 Met Glu Ala Leu Ser Leu Pro Glu Pro Ala Ser Gly Ala Gly Glu Glu
1025                1030                1035                1040

 ata gca gaa gcc ctt tct agg cct gga cgg gaa gca tgt ctg gaa gcg     3168
 Ile Ala Glu Ala Leu Ser Arg Pro Gly Arg Glu Ala Cys Leu Glu Ala
                1045                1050                1055

 cga gcg cac aca ggt gat ggg gct aag cct gac tca ccc caa aag gag     3216
 Arg Ala His Thr Gly Asp Gly Ala Lys Pro Asp Ser Pro Gln Lys Glu
            1060                1065                1070

 acc ctg gag gtt gag aac cag cag gaa gga ggc ctg aag cca ctg gca     3264
 Thr Leu Glu Val Glu Asn Gln Gln Glu Gly Gly Leu Lys Pro Leu Ala
        1075                1080                1085

 cag gaa cat gga ccc agg tca gca ctt gga ggt gca agg gag gtc ccc     3312
 Gln Glu His Gly Pro Arg Ser Ala Leu Gly Gly Ala Arg Glu Val Pro
    1090                1095                1100

 gat gcg cct cct gct gcc tgc cct gag gtc agc cag gcc cgg ctc ctg     3360
 Asp Ala Pro Pro Ala Ala Cys Pro Glu Val Ser Gln Ala Arg Leu Leu
1105                1110                1115                1120

 agc cca gcc agg gag gaa aga ggc ctg agt ggc aag tcc acc ccg gag     3408
 Ser Pro Ala Arg Glu Glu Arg Gly Leu Ser Gly Lys Ser Thr Pro Glu
                1125                1130                1135

 ccc acg ctt ccc tca gct gtg gcc aca gag gcc agt ctg gac tcc tgc     3456
 Pro Thr Leu Pro Ser Ala Val Ala Thr Glu Ala Ser Leu Asp Ser Cys
            1140                1145                1150

 cca gag tct tca gta ggg gct gtg tcc agt ctg gac aga ggc tgc cct     3504
 Pro Glu Ser Ser Val Gly Ala Val Ser Ser Leu Asp Arg Gly Cys Pro
        1155                1160                1165

 gac gcg cct gcc ccc acg tct gca cca acc tcc cag cag ccg gag cct     3552
 Asp Ala Pro Ala Pro Thr Ser Ala Pro Thr Ser Gln Gln Pro Glu Pro
    1170                1175                1180

 gta ctg ggt ctg ggc agt gtt gag caa ccc cac gaa gta ccc agt gtc     3600
 Val Leu Gly Leu Gly Ser Val Glu Gln Pro His Glu Val Pro Ser Val
1185                1190                1195                1200

 ctt ggc acc ccc ttg ctg cag ccc cca gaa aac ctt gcc aag ggt cag     3648
 Leu Gly Thr Pro Leu Leu Gln Pro Pro Glu Asn Leu Ala Lys Gly Gln
                1205                1210                1215

 ccc agc acg ccc gtg gac agg ccc ctg ggc cct gac cct tct gct cct     3696
 Pro Ser Thr Pro Val Asp Arg Pro Leu Gly Pro Asp Pro Ser Ala Pro
            1220                1225                1230

 ggt acc ctt gct ggg gca gcc cta ccc cca ctg gag ccc cca gcc ccc     3744
 Gly Thr Leu Ala Gly Ala Ala Leu Pro Pro Leu Glu Pro Pro Ala Pro
        1235                1240                1245

 tgc ctg tgc cag gac ccc cag gaa gac tct gtg gaa gac gag gag ccc     3792
 Cys Leu Cys Gln Asp Pro Gln Glu Asp Ser Val Glu Asp Glu Glu Pro
    1250                1255                1260

 cca ggc tct ctg ggc ctc cca ccg ccc cag gca gga gtc cag cct gcc     3840
 Pro Gly Ser Leu Gly Leu Pro Pro Pro Gln Ala Gly Val Gln Pro Ala
1265                1270                1275                1280

 gct gct gct gtc tca gga acc aca cag cct ctg ggg act ggg ccg cga     3888
 Ala Ala Ala Val Ser Gly Thr Thr Gln Pro Leu Gly Thr Gly Pro Arg
                1285                1290                1295

 gtc agc ctc tcg cct cac tcc cca ctc ctc agc ccc aag gtg gcc tcc     3936
 Val Ser Leu Ser Pro His Ser Pro Leu Leu Ser Pro Lys Val Ala Ser
            1300                1305                1310

 atg gat gcc aaa gac ctg gcc ttg cag atc ttg ccg cct tgc caa gtg     3984
 Met Asp Ala Lys Asp Leu Ala Leu Gln Ile Leu Pro Pro Cys Gln Val
        1315                1320                1325

 cct cct ccc tct ggg ccc cag agc cca gct ggc cct caa ggg ctc tca     4032
 Pro Pro Pro Ser Gly Pro Gln Ser Pro Ala Gly Pro Gln Gly Leu Ser
    1330                1335                1340

 gcc ccc gag cag caa gag gat gag gac agc ctg gag gaa gac tcg cct     4080
 Ala Pro Glu Gln Gln Glu Asp Glu Asp Ser Leu Glu Glu Asp Ser Pro
1345                1350                1355                1360

 cgg gcc ctg ggc tcg ggc cag cat tcg gat agc cac ggg gag tca tca     4128
 Arg Ala Leu Gly Ser Gly Gln His Ser Asp Ser His Gly Glu Ser Ser
                1365                1370                1375

 gcc gag ctg gac gag cag gac atc ttg gct cct cag acc gtg cag tgt     4176
 Ala Glu Leu Asp Glu Gln Asp Ile Leu Ala Pro Gln Thr Val Gln Cys
            1380                1385                1390

 cca gcc cag gcc cca gca ggc ggc agt gag gag acc atc gcc aaa gcc     4224
 Pro Ala Gln Ala Pro Ala Gly Gly Ser Glu Glu Thr Ile Ala Lys Ala
        1395                1400                1405

 aag cag agt cgc agt gag aag aag gcc cga aag gca atg tca aag ctg     4272
 Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met Ser Lys Leu
    1410                1415                1420

 ggc ttg cgg cag att cag gga gtc acc agg atc acc atc cag aag tcc     4320
 Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile Thr Ile Gln Lys Ser
1425                1430                1435                1440

 aag aac atc ctc ttt gtc atc gcc aag cct gat gtc ttc aag agc cca     4368
 Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp Val Phe Lys Ser Pro
                1445                1450                1455

 gcc tca gac act tat gtg gtc ttt ggc gag gcc aag att gag gac ctg     4416
 Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala Lys Ile Glu Asp Leu
            1460                1465                1470

 tcc cag caa gtg cac aaa gcc gca gct gag aag ttt aag gtg ccc tca     4464
 Ser Gln Gln Val His Lys Ala Ala Ala Glu Lys Phe Lys Val Pro Ser
        1475                1480                1485

 gag ccc tca gcc ttg gtc cct gag tca gca ccc agg ccc cgg gtg agg     4512
 Glu Pro Ser Ala Leu Val Pro Glu Ser Ala Pro Arg Pro Arg Val Arg
    1490                1495                1500

 ctg gag tgc aag gaa gag gaa gag gag gag gag gaa gag gtg gac gag     4560
 Leu Glu Cys Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Glu
1505                1510                1515                1520

 gcg ggg ctg gaa ctg cgt gac att gag ctg gtg atg gcg cag gcc aat     4608
 Ala Gly Leu Glu Leu Arg Asp Ile Glu Leu Val Met Ala Gln Ala Asn
                1525                1530                1535

 gtg tcc agg gcc aag gcc gtg cgg gct ctg aga gac aac cac agt gac     4656
 Val Ser Arg Ala Lys Ala Val Arg Ala Leu Arg Asp Asn His Ser Asp
            1540                1545                1550

 atc gtc aac gcc atc atg gaa ctg acc atg tag ccactgac cggaagctgg     4707
 Ile Val Asn Ala Ile Met Glu Leu Thr Met 
        1555                1560

 agccatccta cgccttccct cagctctgct actcaataaa tcggtgtccc ttcaaaaaaa   4767

 aaaaaa                                                              4773




      <210> 161
      <211> 961
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (525)..(815)

      <400> 161
 cggtaccgct ccggaattcc cgggaaatcg gacaacattt actgagtggt tgtatgtccc     60

 aggcactggg ctaaatactt ttaaaacatt atttaaccat cataataaac acattagctt    120

 aatactgtgg agaaagtaaa cagtttctcg cctggccata ggtgccagtg gcttcccgac    180

 tggccgaggc tgcgcgcctg attcctgttt tggcggctca accggttggt tcctggagat    240

 tgttttgtcc ggtactactg tgttatttct aaaaccctgc ccgctttttc catccccgca    300

 catgcacaac aacggatgca atcctggaca ttttaaaaag ttgatagttt tcattttcgc    360

 tcctcaaagg agcctggggt aggaggaatc cgcagtggga gctaacgatc ctaagcgttg    420

 tttctctgtt cttcttttct tctatagaac attataaaca tcactggttc ccagaaaagc    480

 catgcaaggg atcgggttac cgttgtattc gcatcaacca taaa atg gat cct ctg     536
                                                  Met Asp Pro Leu
                                                    1

 att gga cag gca gca cag cgg att gga ctg agc agt cag gag ctg ttc      584
 Ile Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe
   5                  10                  15                  20

 agg ctt ctc cca agt gaa ctc aca ctc tgg gtt gac ccc tat gaa gtg      632
 Arg Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val
                  25                  30                  35

 tcc tac aga att gga gag gat ggc tcc atc tgt gtg ctg tat gaa gcc      680
 Ser Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala
              40                  45                  50

 tca cca gca gga ggt agc act caa aac agc acc aac gtg caa atg gta      728
 Ser Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met Val
          55                  60                  65

 gac agc cga atc agc tgt aag gag gaa ctt ctc ttg ggc aga acg agc      776
 Asp Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser
      70                  75                  80

 cct tcc aaa aac tac aat atg atg act gta tca ggt taa gatatagtct       825
 Pro Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
  85                  90                  95

 gtggatggat catctgatga tgatggataa atttgatttt tgctttgggt gggctcctct    885

 tggggatgga ttatggaatt taaaccatgt cacagctgtg aagatctggc acaagataga    945

 atggtaaaaa aaaaaa                                                    961




      <210> 162
      <211> 1935
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(1896)

      <400> 162
 gcacgagtcc tccactgccg gggctgggcc cggccgcggg aaggaccgaa ggggatacag     60

 cgtgtccctg cggcggctgc aagaggacta agc atg aat ggc agc cgg aga gtc     114
                                      Met Asn Gly Ser Arg Arg Val
                                        1               5

 aga gca acc tct gtc ctt ccc aga tat ggt cca ccg tgc cta ttt aaa      162
 Arg Ala Thr Ser Val Leu Pro Arg Tyr Gly Pro Pro Cys Leu Phe Lys
          10                  15                  20

 gga cac ttg agc acc aaa agt aat gct ttt tgc act gac tcc tct tct      210
 Gly His Leu Ser Thr Lys Ser Asn Ala Phe Cys Thr Asp Ser Ser Ser
      25                  30                  35

 ctc aga cta agc act ctc cag ctg gtc aag aat cac atg gct gtt cac      258
 Leu Arg Leu Ser Thr Leu Gln Leu Val Lys Asn His Met Ala Val His
  40                  45                  50                  55

 tat aat aaa atc ctt tca gcc aaa gct gca gta gac tgc tcg gtt cca      306
 Tyr Asn Lys Ile Leu Ser Ala Lys Ala Ala Val Asp Cys Ser Val Pro
                  60                  65                  70

 gta agc gtg agt acc agc ata aag tat gca gac caa caa cga aga gag      354
 Val Ser Val Ser Thr Ser Ile Lys Tyr Ala Asp Gln Gln Arg Arg Glu
              75                  80                  85

 aaa ctc aaa aag gaa tta gca caa tgt gaa aaa gag ttc aaa tta act      402
 Lys Leu Lys Lys Glu Leu Ala Gln Cys Glu Lys Glu Phe Lys Leu Thr
          90                  95                 100

 aaa act gca atg cga gcc aat tat aaa aat aat tcc aag tca ctt ttt      450
 Lys Thr Ala Met Arg Ala Asn Tyr Lys Asn Asn Ser Lys Ser Leu Phe
     105                 110                 115

 aat acc tta caa aag ccc tca ggc gaa ccg caa att gag gat gac atg      498
 Asn Thr Leu Gln Lys Pro Ser Gly Glu Pro Gln Ile Glu Asp Asp Met
 120                 125                 130                 135

 tta aaa gaa gaa atg aat gga ttt tca tcc ttt gca agg tca cta gta      546
 Leu Lys Glu Glu Met Asn Gly Phe Ser Ser Phe Ala Arg Ser Leu Val
                 140                 145                 150

 ccc tct tca gag aga cta cac cta agt cta cat aaa tcc agt aaa gtc      594
 Pro Ser Ser Glu Arg Leu His Leu Ser Leu His Lys Ser Ser Lys Val
             155                 160                 165

 atc aca aat ggt cct gag aag aac tcc agt tcc tcc ccg tcc agt gtg      642
 Ile Thr Asn Gly Pro Glu Lys Asn Ser Ser Ser Ser Pro Ser Ser Val
         170                 175                 180

 gat tat gca gcc tcc ggg ccc cgg aaa ctg agc tct gga gcc ctg tat      690
 Asp Tyr Ala Ala Ser Gly Pro Arg Lys Leu Ser Ser Gly Ala Leu Tyr
     185                 190                 195

 ggc aga agg ccc aga agc aca ttc cca aat tcc cac cgg ttt cag tta      738
 Gly Arg Arg Pro Arg Ser Thr Phe Pro Asn Ser His Arg Phe Gln Leu
 200                 205                 210                 215

 gtc att tcg aaa gca ccc agt ggg gat ctt ttg gat aaa cat tct gaa      786
 Val Ile Ser Lys Ala Pro Ser Gly Asp Leu Leu Asp Lys His Ser Glu
                 220                 225                 230

 ctc ttt tct aac aaa caa ttg cca ttc act cct cgc act tta aaa aca      834
 Leu Phe Ser Asn Lys Gln Leu Pro Phe Thr Pro Arg Thr Leu Lys Thr
             235                 240                 245

 gaa gca aaa tct ttc ctg tca cag tat cgc tat tat aca cct gcc aaa      882
 Glu Ala Lys Ser Phe Leu Ser Gln Tyr Arg Tyr Tyr Thr Pro Ala Lys
         250                 255                 260

 aga aaa aag gat ttt aca gat caa cgg ata gaa gct gaa acc cag act      930
 Arg Lys Lys Asp Phe Thr Asp Gln Arg Ile Glu Ala Glu Thr Gln Thr
     265                 270                 275

 gaa tta agc ttt aaa tct gag ttg ggg aca gct gag act aaa aac atg      978
 Glu Leu Ser Phe Lys Ser Glu Leu Gly Thr Ala Glu Thr Lys Asn Met
 280                 285                 290                 295

 aca gat tca gaa atg aac ata aag cag gta gca tct aat tgt gtg aca     1026
 Thr Asp Ser Glu Met Asn Ile Lys Gln Val Ala Ser Asn Cys Val Thr
                 300                 305                 310

 tat gat gcc aaa gaa aaa ata gct cct tta cct tta gaa gag cat gac     1074
 Tyr Asp Ala Lys Glu Lys Ile Ala Pro Leu Pro Leu Glu Glu His Asp
             315                 320                 325

 tca aca tgg gat gag att aag gat gat gct ctt cag cat tcc tca cca     1122
 Ser Thr Trp Asp Glu Ile Lys Asp Asp Ala Leu Gln His Ser Ser Pro
         330                 335                 340

 agg gca atg tgt cag tat tcc ctg aag ccc cct tca act cgt aaa atc     1170
 Arg Ala Met Cys Gln Tyr Ser Leu Lys Pro Pro Ser Thr Arg Lys Ile
     345                 350                 355

 tac tct gat gaa gaa gaa ctg ttg tat ctg agt ttc att gaa gat gta     1218
 Tyr Ser Asp Glu Glu Glu Leu Leu Tyr Leu Ser Phe Ile Glu Asp Val
 360                 365                 370                 375

 aca gat gaa att ttg aaa ctt ggt tta ttt tca aac agg ttt tta gaa     1266
 Thr Asp Glu Ile Leu Lys Leu Gly Leu Phe Ser Asn Arg Phe Leu Glu
                 380                 385                 390

 cga ctg ttc gag cga cat ata aaa caa aat aaa cat ttg gag gag gaa     1314
 Arg Leu Phe Glu Arg His Ile Lys Gln Asn Lys His Leu Glu Glu Glu
             395                 400                 405

 aaa atg cgc cac ctg ctg cat gtc ctg aaa gta gac tta ggc tgc aca     1362
 Lys Met Arg His Leu Leu His Val Leu Lys Val Asp Leu Gly Cys Thr
         410                 415                 420

 tcg gag gaa aac tcg gta aag caa aat gat gtt gat atg ttg aat gta     1410
 Ser Glu Glu Asn Ser Val Lys Gln Asn Asp Val Asp Met Leu Asn Val
     425                 430                 435

 ttt gat ttt gaa aag gct ggg aat tca gaa cca aat gaa tta aaa aat     1458
 Phe Asp Phe Glu Lys Ala Gly Asn Ser Glu Pro Asn Glu Leu Lys Asn
 440                 445                 450                 455

 gaa agt gaa gta aca att cag cag gaa cgt caa caa tac caa aag gct     1506
 Glu Ser Glu Val Thr Ile Gln Gln Glu Arg Gln Gln Tyr Gln Lys Ala
                 460                 465                 470

 ttg gat atg tta ttg tcg gca cca aag gat gag aac gag ata ttc cct     1554
 Leu Asp Met Leu Leu Ser Ala Pro Lys Asp Glu Asn Glu Ile Phe Pro
             475                 480                 485

 tca cca act gaa ttt ttc atg cct att tat aaa tca aag cat tca gaa     1602
 Ser Pro Thr Glu Phe Phe Met Pro Ile Tyr Lys Ser Lys His Ser Glu
         490                 495                 500

 ggg gtt ata att caa cag gtg aat gat gaa aca aat ctt gaa act tca     1650
 Gly Val Ile Ile Gln Gln Val Asn Asp Glu Thr Asn Leu Glu Thr Ser
     505                 510                 515

 act ttg gat gaa aat cat cca agt att tca gac agt tta aca gat cgg     1698
 Thr Leu Asp Glu Asn His Pro Ser Ile Ser Asp Ser Leu Thr Asp Arg
 520                 525                 530                 535

 gaa act tct gtg aat gtc att gaa ggt gat agt gac cct gaa aag gtt     1746
 Glu Thr Ser Val Asn Val Ile Glu Gly Asp Ser Asp Pro Glu Lys Val
                 540                 545                 550

 gag att tca aat gga tta tgt ggt ctt aac aca tca ccc tcc caa tct     1794
 Glu Ile Ser Asn Gly Leu Cys Gly Leu Asn Thr Ser Pro Ser Gln Ser
             555                 560                 565

 gtt cag ttc tcc agt gtc aaa ggc gac aat aat cat gac atg gag tta     1842
 Val Gln Phe Ser Ser Val Lys Gly Asp Asn Asn His Asp Met Glu Leu
         570                 575                 580

 tca act ctt aaa atc atg gaa atg agc att gag gac tgc cct ttg gat     1890
 Ser Thr Leu Lys Ile Met Glu Met Ser Ile Glu Asp Cys Pro Leu Asp
     585                 590                 595

 gtt taa tcttcattaa taaatacctc aaatggccaa aaaaaaaaa                  1935
 Val 
 600





      <210> 163
      <211> 607
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (384)..(542)

      <400> 163
 gctactacta ctaaattcgc ggccgcgtcg actgacgacc tacgcacacg agaacatgcc     60

 tgtgagtgct ttggtccagg tttcggcgga gatctcgctg ttctgtccga actctcccct    120

 cacgctgatt tcggatcgta gagggtcctc atttaccctc tgcacttctt aggacattaa    180

 ctccagggac cgcagcggcc cacgggccac ccgcatagac gggagcggag aggagataag    240

 atggcggccc agctgcgcag acaccagggg cggcgagggg cgagctctcc ccgctcgcaa    300

 aggatctcct tcatccctct ccagaagagg agaagaggaa acacaagaag aaacgcctgg    360

 tgcagagccc caattcctac ttc    atg gat gtg aaa tgc cca gga tgc tat     410
                              Met Asp Val Lys Cys Pro Gly Cys Tyr
                                1               5

 aaa atc acc acg gtc ttt agc cat gca caa acg gta gtt ttg tgt gtt      458
 Lys Ile Thr Thr Val Phe Ser His Ala Gln Thr Val Val Leu Cys Val
  10                  15                  20                  25

 ggc tgc tcc act gtc ctc tgc cag cct aca gga gga aaa gca agg ctt      506
 Gly Cys Ser Thr Val Leu Cys Gln Pro Thr Gly Gly Lys Ala Arg Leu
                  30                  35                  40

 aca gaa gga tgt tcc ttc agg agg aag cag cac taa aagc actctgagtc      556
 Thr Glu Gly Cys Ser Phe Arg Arg Lys Gln His 
              45                  50

 aagatgagtg ggaaaccatc tcaataaaca cattttggat aaaaaaaaaa a             607




      <210> 164
      <211> 354
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(233)

      <220>
      <221> misc_feature
      <222> (1)...(354)
      <223> n = a,t,c or g

      <400> 164
 tttccact atg gct tcc agc act gtc ccg gtg agc gct gct ggc tcg gct      50
          Met Ala Ser Ser Thr Val Pro Val Ser Ala Ala Gly Ser Ala
            1               5                  10

 aat gaa act ccc gaa ata ccg gac aac gtg gga gat tgg ctt cgg ggc       98
 Asn Glu Thr Pro Glu Ile Pro Asp Asn Val Gly Asp Trp Leu Arg Gly
  15                  20                  25                  30

 gtc tac cgc ttt gcc act gat agg aat gac ttc cgg agg aac ttg ata      146
 Val Tyr Arg Phe Ala Thr Asp Arg Asn Asp Phe Arg Arg Asn Leu Ile
                  35                  40                  45

 cta aat ttg gga ctc ttt gct gcg gga gtt tgg ctg gcc agg aac ttg      194
 Leu Asn Leu Gly Leu Phe Ala Ala Gly Val Trp Leu Ala Arg Asn Leu
              50                  55                  60

 agt gac att gac ctc atg gca cct cag cca ggg gtg tag ccaagtagac       243
 Ser Asp Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
          65                  70

 aaatggaatc ctgtgctgaa cccgaatctt tccaaaaaac agcctacaat ctgtggacca    303

 ccacaaagat gtgcccttna ttggcagctt gaaagtttga ttcanatggg g             354




      <210> 165
      <211> 792
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(578)

      <400> 165
 tgactacgcc aagcttggca cgagggtgag ttacttcgct cggagcgggc gaggggacgc     60

 gtgggcggag cggggctggc cagcctcggc ccccatgacc cgctgtcctg tgccctttcc    120

 cagcg    atg ggc gtg cag ccc ccc aac ttc tcc tgg gtg ctt ccg ggc     167
          Met Gly Val Gln Pro Pro Asn Phe Ser Trp Val Leu Pro Gly
            1               5                  10

 cgg ctg gcg gga ctg gcg ctg ccg cgg ctc ccc gcc cac tac cag ttc      215
 Arg Leu Ala Gly Leu Ala Leu Pro Arg Leu Pro Ala His Tyr Gln Phe
  15                  20                  25                  30

 ctg ttg gac ctg ggc gtg cgg cac ctg gtg tcc ctg acg gag cgc ggg      263
 Leu Leu Asp Leu Gly Val Arg His Leu Val Ser Leu Thr Glu Arg Gly
                  35                  40                  45

 ccc cct cac agc gac agc tgc ccc ggc ctc acc ctg cac cgc ctg cgc      311
 Pro Pro His Ser Asp Ser Cys Pro Gly Leu Thr Leu His Arg Leu Arg
              50                  55                  60

 atc ccc gac ttc tgc ccg ccg gcc ccc gac cag atc gac cgc ttc gtg      359
 Ile Pro Asp Phe Cys Pro Pro Ala Pro Asp Gln Ile Asp Arg Phe Val
          65                  70                  75

 cag atc gtg gac gag gcc aac gca cgg gga gag gct gtg gga gtg cac      407
 Gln Ile Val Asp Glu Ala Asn Ala Arg Gly Glu Ala Val Gly Val His
      80                  85                  90

 tgt gct ctg ggc ttt ggc cgc act ggc acc atg ctg gcc tgt tac ctg      455
 Cys Ala Leu Gly Phe Gly Arg Thr Gly Thr Met Leu Ala Cys Tyr Leu
  95                 100                 105                 110

 gtg aag gag cgg ggc ttg gct gca gga gat gcc att gct gaa atc cga      503
 Val Lys Glu Arg Gly Leu Ala Ala Gly Asp Ala Ile Ala Glu Ile Arg
                 115                 120                 125

 cga cta cga ccc ggc tcc atc gag acc tat gag cag gag aaa gca gtc      551
 Arg Leu Arg Pro Gly Ser Ile Glu Thr Tyr Glu Gln Glu Lys Ala Val
             130                 135                 140

 ttc cag ttc tac cag cga acg aaa taa ggggc cttagtaccc ttctaccagg      603
 Phe Gln Phe Tyr Gln Arg Thr Lys 
         145                 150

 ccctcactcc ccttccccat gttgtcgatg gggccagaga tgaagggaag tggactaaag    663

 tattaaaccc tctagctccc attggctgaa gacactgaag tagcccaccc ctgcaggcag    723

 gtcctgattg aaggggaggc ttgtactgct ttgttgaata aatgagtttt acgaaccaaa    783

 aaaaaaaaa                                                            792




      <210> 166
      <211> 1863
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (451)..(1695)

      <400> 166
 cggtgggcac cgcgcgcagc tagggagccg agaaccgcgg cgagccccga ggacgcccag     60

 agcgcgaggg tcgctgcgcc tcgcagagcc ggagccgagt cgagccgggc gcccgggctg    120

 cctggccgcg gcggcatggg ggctgccccc gcggctctcc gcgctgcccg ccacctgcct    180

 cggccagtgg ccggaggcag gagcgcgtct gagcccatgg cgatggggac ccgccgccta    240

 ccgcctccac ccccgcctgc cccgtcaacg cgacagctcc cgggcaccat gcgaagccgc    300

 cccgagcctc cgccgctgcg tctgcctgct gctcgccgcg atcctggacc tggcgcgcgg    360

 tacctgacag tcaagcattg atgcctctcc cccctgtggt ggctggagac gccgtgagct    420

 ttgaagtgta acttcaggac agatgggcgc     atg cgg gag atc gtg tgg tac     471
                                      Met Arg Glu Ile Val Trp Tyr
                                        1               5

 cgg gtg acg gat ggt ggc acc atc aag caa aag atc ttc acc ttc gac      519
 Arg Val Thr Asp Gly Gly Thr Ile Lys Gln Lys Ile Phe Thr Phe Asp
          10                  15                  20

 gcc atg ttc tcc acc aac tac tca cac atg gag aac tac cgc aag cga      567
 Ala Met Phe Ser Thr Asn Tyr Ser His Met Glu Asn Tyr Arg Lys Arg
      25                  30                  35

 gag gac ctg gtg tac cag tcc act gtg agg ctg ccc gag gtc cgg atc      615
 Glu Asp Leu Val Tyr Gln Ser Thr Val Arg Leu Pro Glu Val Arg Ile
  40                  45                  50                  55

 tca gac aat ggt ccc tat gag tgc cat gtg ggc atc tac gac cgc gcc      663
 Ser Asp Asn Gly Pro Tyr Glu Cys His Val Gly Ile Tyr Asp Arg Ala
                  60                  65                  70

 acc agg gag aag gtg gtc ctg gca tca ggc aac atc ttc ctc aac gtc      711
 Thr Arg Glu Lys Val Val Leu Ala Ser Gly Asn Ile Phe Leu Asn Val
              75                  80                  85

 atg gct cct ccc acc tcc att gaa gtg gtg gct gct gac aca cca gcc      759
 Met Ala Pro Pro Thr Ser Ile Glu Val Val Ala Ala Asp Thr Pro Ala
          90                  95                 100

 ccc ttc agc cgc tac caa gcc cag aac ttc acg ctg gtc tgc atc gtg      807
 Pro Phe Ser Arg Tyr Gln Ala Gln Asn Phe Thr Leu Val Cys Ile Val
     105                 110                 115

 tct gga gga aaa cca gca ccc atg gtt tat ttc aaa cga gat ggg gaa      855
 Ser Gly Gly Lys Pro Ala Pro Met Val Tyr Phe Lys Arg Asp Gly Glu
 120                 125                 130                 135

 cca atc gac gca gtg ccc cta tca gag cca cca gct gcg agc tcc ggc      903
 Pro Ile Asp Ala Val Pro Leu Ser Glu Pro Pro Ala Ala Ser Ser Gly
                 140                 145                 150

 ccc cta cag gac agc agg ccc ttc cgc agc ctt ctg cac cgt gac ctg      951
 Pro Leu Gln Asp Ser Arg Pro Phe Arg Ser Leu Leu His Arg Asp Leu
             155                 160                 165

 gat gac acc aag atg cag aag tca ctg tcc ctc ctg gac gcc gag aac      999
 Asp Asp Thr Lys Met Gln Lys Ser Leu Ser Leu Leu Asp Ala Glu Asn
         170                 175                 180

 cgg ggt ggg cga ccc tac acg gag cgc ccc tcc cgt ggc ctg acc cca     1047
 Arg Gly Gly Arg Pro Tyr Thr Glu Arg Pro Ser Arg Gly Leu Thr Pro
     185                 190                 195

 gat ccc aac atc ctc ctc cag cca acc aca gag aac ata cca gag acg     1095
 Asp Pro Asn Ile Leu Leu Gln Pro Thr Thr Glu Asn Ile Pro Glu Thr
 200                 205                 210                 215

 gtc gtg agc cgt gag ttt ccc cgc tgg gtc cac agc gcc gag ccc acc     1143
 Val Val Ser Arg Glu Phe Pro Arg Trp Val His Ser Ala Glu Pro Thr
                 220                 225                 230

 tac ttc ctg cgc cac agc cgc acc ccg agc agt gac ggc act gtg gaa     1191
 Tyr Phe Leu Arg His Ser Arg Thr Pro Ser Ser Asp Gly Thr Val Glu
             235                 240                 245

 gta cgt gcc ctg ctc acc tgg acc ctc aac cca cag atc gac aac gag     1239
 Val Arg Ala Leu Leu Thr Trp Thr Leu Asn Pro Gln Ile Asp Asn Glu
         250                 255                 260

 gcc ctc ttc agc tgc gag gtc aag cac cca gct ctg tcg atg ccc atg     1287
 Ala Leu Phe Ser Cys Glu Val Lys His Pro Ala Leu Ser Met Pro Met
     265                 270                 275

 cag gca gag gtc acg ctg gtt gcc ccc aaa gga ccc aaa att gtg atg     1335
 Gln Ala Glu Val Thr Leu Val Ala Pro Lys Gly Pro Lys Ile Val Met
 280                 285                 290                 295

 acg ccc agc aga gcc cgg gta ggg gac aca gtg agg att ctg gtc cat     1383
 Thr Pro Ser Arg Ala Arg Val Gly Asp Thr Val Arg Ile Leu Val His
                 300                 305                 310

 ggg ttt cag aac gaa gtc ttc ccg gag ccc atg ttc acg tgg acg cgg     1431
 Gly Phe Gln Asn Glu Val Phe Pro Glu Pro Met Phe Thr Trp Thr Arg
             315                 320                 325

 gtt ggg agc cgc ctc ctg gac ggc agc gct gag ttc gac ggg aag gag     1479
 Val Gly Ser Arg Leu Leu Asp Gly Ser Ala Glu Phe Asp Gly Lys Glu
         330                 335                 340

 ctg gtg ctg gag cgg gtt ccc gcc gag ctc aat ggc tcc atg tat cgc     1527
 Leu Val Leu Glu Arg Val Pro Ala Glu Leu Asn Gly Ser Met Tyr Arg
     345                 350                 355

 tgc acc gcc cag aac cca ctg ggc tcc acc gac acg cac acc cgg ctc     1575
 Cys Thr Ala Gln Asn Pro Leu Gly Ser Thr Asp Thr His Thr Arg Leu
 360                 365                 370                 375

 atc gtg ttt gaa aac cca aat atc cca aga gga acg gag gac tct aat     1623
 Ile Val Phe Glu Asn Pro Asn Ile Pro Arg Gly Thr Glu Asp Ser Asn
                 380                 385                 390

 ggt tcc att ggc ccc act ggt gcc cgg ctc acc ttg gtg ctc gcc ctg     1671
 Gly Ser Ile Gly Pro Thr Gly Ala Arg Leu Thr Leu Val Leu Ala Leu
             395                 400                 405

 aca gtg att ctg gag ctg acg tga aggcacccgc cccggccact ccatcaggca    1725
 Thr Val Ile Leu Glu Leu Thr 
         410

 ctgacatctc cacgaccggt tttcatttct tttctaaact atttccagtc ttgttcttag   1785

 tctctttcca tctgtgtctt ggcttcttca gtcggtttaa ttaaaacaaa cagaacaatt   1845

 ttccccaaaa aaaaaaaa                                                 1863




      <210> 167
      <211> 945
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (336)..(713)

      <400> 167
 tgatctggat ctgaagggtc tgcggatctt cagaggctta actaccgggt ggaaaggatg     60

 ggttttgttc gggggtgatg agattatcta agagacggtg aagaggcatc atctgccgac    120

 actgtgtgca tgtggaaggc tgctggattc caccacatct gtgtgggttc ttcctccagc    180

 cccccaaaaa agagcccatg gaaagccaat ctgtgtactt ctatttttag aaactagatg    240

 atggccattt aaacaactct ttgagctctc cagttcaagc ggacgtgtac ttcccacgac    300

 tgatagttcc attttgtggg cacattaaag gtggc   atg aga cca ggc aag aag     353
                                          Met Arg Pro Gly Lys Lys
                                            1               5

 gtg tta gtg atg ggc atc gta gac ctc aac cca gag agc ttt gca atc      401
 Val Leu Val Met Gly Ile Val Asp Leu Asn Pro Glu Ser Phe Ala Ile
              10                  15                  20

 agc ttg acc tgt ggg gac tca gaa gac cct cct gcc gat gtg gca atc      449
 Ser Leu Thr Cys Gly Asp Ser Glu Asp Pro Pro Ala Asp Val Ala Ile
          25                  30                  35

 gaa ctc aaa gct gtg ttc aca gat cgg cag cta ctc aga aat tct tgt      497
 Glu Leu Lys Ala Val Phe Thr Asp Arg Gln Leu Leu Arg Asn Ser Cys
      40                  45                  50

 ata tct ggg gag agg ggt gaa gaa cag tca gca atc cct tac ttt cca      545
 Ile Ser Gly Glu Arg Gly Glu Glu Gln Ser Ala Ile Pro Tyr Phe Pro
  55                  60                  65                  70

 ttc att cca gac cag cca ttc agg gtg gaa att ctt tgt gag cac cca      593
 Phe Ile Pro Asp Gln Pro Phe Arg Val Glu Ile Leu Cys Glu His Pro
                  75                  80                  85

 cgt ttc cga gtg ttt gtg gat gga cac caa ctt ttt gat ttt tac cat      641
 Arg Phe Arg Val Phe Val Asp Gly His Gln Leu Phe Asp Phe Tyr His
              90                  95                 100

 cgc att caa acg tta tct gca att gac acc ata aag ata aat gga gac      689
 Arg Ile Gln Thr Leu Ser Ala Ile Asp Thr Ile Lys Ile Asn Gly Asp
         105                 110                 115

 ctc cag atc acc aag ctt ggc tga tttaaaccac ctctatttca aataggatca     743
 Leu Gln Ile Thr Lys Leu Gly 
     120                 125

 cgtgccacaa ctatctgact gttggtctgg aagaagtgtc ctagcaagat ctggagactt    803

 aaaaagaaaa caaaaacaaa tggcaagttt cacttaaggg tggtttgccc ttaagaagaa    863

 agctgttggg acaaagacac cgagccatta tacccagaat aaaataatac atttatgctg    923

 gattttattc aaaaaaaaaa aa                                             945




      <210> 168
      <211> 5714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (262)..(4755)

      <400> 168
 ccgggtacga cccacgcgtt cggacacacc tttgtcagga catgtttgga attttagagt     60

 tgaaagaaac aaggcggaga gaaagaaaag tgaacatttt tgaaagatca ctcagcttta    120

 acacaccttg gctgggtctg gataaaaaaa aagtgagcac tgcaaatttc tagaagaaaa    180

 catcaggaga agaaagagag agggggattt attcaaagtt gtttccaatt ccttcaaaac    240

 ctcaaaccag gtggctatgg t  atg gat gta acc aag aaa aac aaa cga gat     291
                          Met Asp Val Thr Lys Lys Asn Lys Arg Asp
                            1               5                  10

 gga act gaa gtc act gag aga att gtc act gaa aca gta acc aca aga      339
 Gly Thr Glu Val Thr Glu Arg Ile Val Thr Glu Thr Val Thr Thr Arg
                  15                  20                  25

 ctt aca tcc tta cca cca aaa ggc ggg acc agc aat ggc tat gct aaa      387
 Leu Thr Ser Leu Pro Pro Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys
              30                  35                  40

 aca gcc tct ctt ggt gga ggg agc cgg ctg gag aaa caa agc ctg act      435
 Thr Ala Ser Leu Gly Gly Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr
          45                  50                  55

 cat ggc agc agc ggc tac ata aac tca act gga agc aca cga ggc cat      483
 His Gly Ser Ser Gly Tyr Ile Asn Ser Thr Gly Ser Thr Arg Gly His
      60                  65                  70

 gcc tcc acc tct agt tac agg agg gct cac tca cct gcc tcc act ctg      531
 Ala Ser Thr Ser Ser Tyr Arg Arg Ala His Ser Pro Ala Ser Thr Leu
  75                  80                  85                  90

 ccc aac tcc cca ggc tca acc ttt gaa agg aaa act cac gtt acc cgc      579
 Pro Asn Ser Pro Gly Ser Thr Phe Glu Arg Lys Thr His Val Thr Arg
                  95                 100                 105

 cat gcg tat gaa ggg agc tcc agt ggc aac tct tct ccg gag tac cct      627
 His Ala Tyr Glu Gly Ser Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro
             110                 115                 120

 cgg aag gaa ttt gca tct tct tca acc aga gga cgg agt caa aca cga      675
 Arg Lys Glu Phe Ala Ser Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg
         125                 130                 135

 gag agt gaa att cga gtt cga ctg cag agt gcg tcc cca tcc acc cga      723
 Glu Ser Glu Ile Arg Val Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg
     140                 145                 150

 tgg aca gaa ttg gat gat gtt aag cgt ttg ctc aag ggg agt cga tcg      771
 Trp Thr Glu Leu Asp Asp Val Lys Arg Leu Leu Lys Gly Ser Arg Ser
 155                 160                 165                 170

 gca agt gtg agc ccc acc cgg aat tcc tcc aac aca ctc ccc atc ccc      819
 Ala Ser Val Ser Pro Thr Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro
                 175                 180                 185

 aag aaa ggc act gtg gag acc aaa att gtg aca gcg agc tcc cag tcg      867
 Lys Lys Gly Thr Val Glu Thr Lys Ile Val Thr Ala Ser Ser Gln Ser
             190                 195                 200

 gtg tca ggc acc tac gat gca atg atc ctg gat gcc aac ctt ccc tcc      915
 Val Ser Gly Thr Tyr Asp Ala Met Ile Leu Asp Ala Asn Leu Pro Ser
         205                 210                 215

 cat gtg tgg tcc tcc acc ctg ccc gcg ggg tcc tcc atg ggg acc tat      963
 His Val Trp Ser Ser Thr Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr
     220                 225                 230

 cac aac aac atg aca acc cag agc tca tcc ctc ctc aac acc aat gcc     1011
 His Asn Asn Met Thr Thr Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala
 235                 240                 245                 250

 tac tct gcg gga tca gtc ttc gga gtt cca aac aac atg gcg tcc tgc     1059
 Tyr Ser Ala Gly Ser Val Phe Gly Val Pro Asn Asn Met Ala Ser Cys
                 255                 260                 265

 tca ccc act ttg cac cct gga ctc agc aca tcc tcc tca gtg ttt ggc     1107
 Ser Pro Thr Leu His Pro Gly Leu Ser Thr Ser Ser Ser Val Phe Gly
             270                 275                 280

 atg cag aac aat ctg gcc ccc agc ttg acc acc ctg tcc cat ggc acc     1155
 Met Gln Asn Asn Leu Ala Pro Ser Leu Thr Thr Leu Ser His Gly Thr
         285                 290                 295

 acc acc act tcc aca gca tat ggg gtg aag aaa aac atg ccc cag agt     1203
 Thr Thr Thr Ser Thr Ala Tyr Gly Val Lys Lys Asn Met Pro Gln Ser
     300                 305                 310

 cct gcg gct gtg aac act ggc gtt tcc acc tcc gcc gcc tgc acc aca     1251
 Pro Ala Ala Val Asn Thr Gly Val Ser Thr Ser Ala Ala Cys Thr Thr
 315                 320                 325                 330

 agt gtg cag agc gat gac ctt ttg cac aag gac tgc aag ttc ctg atc     1299
 Ser Val Gln Ser Asp Asp Leu Leu His Lys Asp Cys Lys Phe Leu Ile
                 335                 340                 345

 cta gag aaa gac aac aca cct gct aag aag gag atg gag ctg ctc atc     1347
 Leu Glu Lys Asp Asn Thr Pro Ala Lys Lys Glu Met Glu Leu Leu Ile
             350                 355                 360

 atg acc aag gac agc ggg aag gtc ttt aca gcc tcc cct gcc agc atc     1395
 Met Thr Lys Asp Ser Gly Lys Val Phe Thr Ala Ser Pro Ala Ser Ile
         365                 370                 375

 gct gca act tct ttt tca gaa gac acc cta aaa aaa aaa aag caa gct     1443
 Ala Ala Thr Ser Phe Ser Glu Asp Thr Leu Lys Lys Lys Lys Gln Ala
     380                 385                 390

 gcc tac aat gct gac tca ggc cta aaa gcc gaa gct aat gga gac ctg     1491
 Ala Tyr Asn Ala Asp Ser Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu
 395                 400                 405                 410

 aag act gtg tcc aca aag ggc aag acc acc act gca gat atc cac agc     1539
 Lys Thr Val Ser Thr Lys Gly Lys Thr Thr Thr Ala Asp Ile His Ser
                 415                 420                 425

 tac agc agc agt ggt ggt ggt ggc agt gga gga ggt ggc ggt gtt ggt     1587
 Tyr Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Val Gly
             430                 435                 440

 ggc gct ggc ggc ggc cct tgg gga cca gcg cca gcc tgg tgc ccc tgc     1635
 Gly Ala Gly Gly Gly Pro Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys
         445                 450                 455

 ggc tcc tgc tgc agc tgg tgg aag tgg ctg ctg ggc ctg ctg ctc acc     1683
 Gly Ser Cys Cys Ser Trp Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr
     460                 465                 470

 tgg ctg cta ctc ctg ggg ctg ctc ttc ggc ctc att gct ctg gcg gag     1731
 Trp Leu Leu Leu Leu Gly Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu
 475                 480                 485                 490

 gag gtg agg aag ctg aag gcg cgt gtg gat gag ctg gag agg atc agg     1779
 Glu Val Arg Lys Leu Lys Ala Arg Val Asp Glu Leu Glu Arg Ile Arg
                 495                 500                 505

 agg agc ata ctg ccc tat ggg gac agc atg gat aga ata gaa aag gac     1827
 Arg Ser Ile Leu Pro Tyr Gly Asp Ser Met Asp Arg Ile Glu Lys Asp
             510                 515                 520

 cgc ctc cag ggc atg gca ccc gcg gcg gga gca gac ctg gac aaa att     1875
 Arg Leu Gln Gly Met Ala Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile
         525                 530                 535

 ggg ctg cac agt gac agc cag gag gag ctc tgg atg ttc gtg agg aag     1923
 Gly Leu His Ser Asp Ser Gln Glu Glu Leu Trp Met Phe Val Arg Lys
     540                 545                 550

 aag cta atg atg gaa cag gaa aat gga aat ctc cga gga agc cct ggc     1971
 Lys Leu Met Met Glu Gln Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly
 555                 560                 565                 570

 cct aaa ggt gac atg gga agt cca ggc cct aaa gga gat cga ggg ttc     2019
 Pro Lys Gly Asp Met Gly Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe
                 575                 580                 585

 cct ggg act cca ggt atc cct ggg ccc ttg ggc cac cca ggt cca caa     2067
 Pro Gly Thr Pro Gly Ile Pro Gly Pro Leu Gly His Pro Gly Pro Gln
             590                 595                 600

 gga cca aag ggt caa aaa ggc agc gtg gga gat cct ggc atg gaa ggc     2115
 Gly Pro Lys Gly Gln Lys Gly Ser Val Gly Asp Pro Gly Met Glu Gly
         605                 610                 615

 ccc atg ggc cag aga ggg cga gaa ggc ccc atg gga cct cgt ggt gag     2163
 Pro Met Gly Gln Arg Gly Arg Glu Gly Pro Met Gly Pro Arg Gly Glu
     620                 625                 630

 gca ggg cct cct gga tct gga gag aaa ggg gaa aga ggg gct gct ggt     2211
 Ala Gly Pro Pro Gly Ser Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly
 635                 640                 645                 650

 gaa cca ggt cct cat ggc cca cct ggt gtc cca ggt tct gtg ggt ccc     2259
 Glu Pro Gly Pro His Gly Pro Pro Gly Val Pro Gly Ser Val Gly Pro
                 655                 660                 665

 aaa ggt tcc agc ggc tct cct ggc cca cag ggc cct cca ggt cct gta     2307
 Lys Gly Ser Ser Gly Ser Pro Gly Pro Gln Gly Pro Pro Gly Pro Val
             670                 675                 680

 ggt ctc caa ggg ctc cga ggt gaa gta gga ctt cct ggt gtc aaa ggt     2355
 Gly Leu Gln Gly Leu Arg Gly Glu Val Gly Leu Pro Gly Val Lys Gly
         685                 690                 695

 gac aaa gga cca gtg gga cca cca gga ccc aaa ggt gac cag ggt gag     2403
 Asp Lys Gly Pro Val Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu
     700                 705                 710

 aaa gga cct cga ggc ctc aca ggc gag cct ggc atg aga ggt ttg cct     2451
 Lys Gly Pro Arg Gly Leu Thr Gly Glu Pro Gly Met Arg Gly Leu Pro
 715                 720                 725                 730

 ggt gct gtt ggt gag ccc ggg gct aaa gga gca atg ggt cct gct ggc     2499
 Gly Ala Val Gly Glu Pro Gly Ala Lys Gly Ala Met Gly Pro Ala Gly
                 735                 740                 745

 cca gac gga cac caa ggc cca aga ggt gaa caa ggt ctt act ggg atg     2547
 Pro Asp Gly His Gln Gly Pro Arg Gly Glu Gln Gly Leu Thr Gly Met
             750                 755                 760

 cct gga atc cgt ggc cca cca gga cct tct gga gac cca gga aag cca     2595
 Pro Gly Ile Arg Gly Pro Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro
         765                 770                 775

 ggt ctc aca gga ccc cag gga cct cag gga ctt ccc ggt acc cct ggc     2643
 Gly Leu Thr Gly Pro Gln Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly
     780                 785                 790

 cga cca gga ata aaa ggt gaa cca gga gct cca ggc aag atc gtg act     2691
 Arg Pro Gly Ile Lys Gly Glu Pro Gly Ala Pro Gly Lys Ile Val Thr
 795                 800                 805                 810

 tcg gag ggg tca tcg atg ctc act gtc cca ggc ccc cca gga cct cct     2739
 Ser Glu Gly Ser Ser Met Leu Thr Val Pro Gly Pro Pro Gly Pro Pro
                 815                 820                 825

 gga gcc atg gga ccc cca gga cct cca ggt gcc cca ggc cct gcc ggc     2787
 Gly Ala Met Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
             830                 835                 840

 cca gct ggt ctc cca gga cat caa gaa gtt ctt aat tta caa ggt ccc     2835
 Pro Ala Gly Leu Pro Gly His Gln Glu Val Leu Asn Leu Gln Gly Pro
         845                 850                 855

 cca ggc cca ccc ggc cca cgt ggg cca cca ggg cct tcc att cca ggc     2883
 Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly
     860                 865                 870

 cca cca gga ccc cga ggc cca cca ggg gag ggt ttg cca ggc cca cca     2931
 Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro
 875                 880                 885                 890

 ggc cca cca gga tcg ttc ctg tcc aac tca gaa acc ttc ctc tcc ggc     2979
 Gly Pro Pro Gly Ser Phe Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly
                 895                 900                 905

 ccc cca ggc cca cct ggc ccc cca ggt ccc aag gga gac caa ggt ccc     3027
 Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro
             910                 915                 920

 cca ggc ccc aga gga cac caa ggc gag caa ggc ctc cca ggt ttc tca     3075
 Pro Gly Pro Arg Gly His Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser
         925                 930                 935

 acc tca ggg tcc agt tct ttc gga ctc aac ctt cag gga cca cca ggc     3123
 Thr Ser Gly Ser Ser Ser Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly
     940                 945                 950

 cca cct ggc ccc cag gga cca aaa ggt gac aaa ggt gat ccg ggt gtt     3171
 Pro Pro Gly Pro Gln Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val
 955                 960                 965                 970

 cca ggg gct ctt ggc att cct agt ggt cct tct gaa ggg gga tca tca     3219
 Pro Gly Ala Leu Gly Ile Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser
                 975                 980                 985

 agt acc atg tac gtg tca ggc ccg cca ggg ccc cct ggg ccc cct ggg     3267
 Ser Thr Met Tyr Val Ser Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly
             990                 995                1000

 cct ccg ggc tct atc agc agc tct ggc cag gag att cag cag tac atc     3315
 Pro Pro Gly Ser Ile Ser Ser Ser Gly Gln Glu Ile Gln Gln Tyr Ile
        1005                1010                1015

 tct gag tac atg cag agt gac agt att aga tct tac cta tcc gga gtt     3363
 Ser Glu Tyr Met Gln Ser Asp Ser Ile Arg Ser Tyr Leu Ser Gly Val
    1020                1025                1030

 cag ggt ccc cca ggc cca cct ggt ccc cca gga cct gtc acc acc atc     3411
 Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Thr Thr Ile
1035                1040                1045                1050

 aca ggc gag act ttc gac tac tca gag ctg gca agc cac gtt gtg agc     3459
 Thr Gly Glu Thr Phe Asp Tyr Ser Glu Leu Ala Ser His Val Val Ser
                1055                1060                1065

 tac tta cgg act tcg ggg tac ggt gtc agc ttg ttc tcg tcc tcc atc     3507
 Tyr Leu Arg Thr Ser Gly Tyr Gly Val Ser Leu Phe Ser Ser Ser Ile
            1070                1075                1080

 tct tct gaa gac atc ctg gct gtg ctg cag cgg gat gac gtg cgt cag     3555
 Ser Ser Glu Asp Ile Leu Ala Val Leu Gln Arg Asp Asp Val Arg Gln
        1085                1090                1095

 tac cta cgt cag tac ttg atg ggc cct cgg ggt ccg cca ggg cca cca     3603
 Tyr Leu Arg Gln Tyr Leu Met Gly Pro Arg Gly Pro Pro Gly Pro Pro
    1100                1105                1110

 gga gcc agt gga gat ggg tcc ctc ctg tct ttg gac tat gca gag ctg     3651
 Gly Ala Ser Gly Asp Gly Ser Leu Leu Ser Leu Asp Tyr Ala Glu Leu
1115                1120                1125                1130

 agt agt cgc att ctc agc tac atg tcg agt tct ggg atc agc att ggg     3699
 Ser Ser Arg Ile Leu Ser Tyr Met Ser Ser Ser Gly Ile Ser Ile Gly
                1135                1140                1145

 ctt cct ggt ccc ccg ggg ccc cct ggc ttg ccg gga acc tcc tat gag     3747
 Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Thr Ser Tyr Glu
            1150                1155                1160

 gag ctc ctc tcc ttg ctg cga ggg tct gaa ttc aga ggc atc gtt gga     3795
 Glu Leu Leu Ser Leu Leu Arg Gly Ser Glu Phe Arg Gly Ile Val Gly
        1165                1170                1175

 ccc cca ggt ccc ccg ggt cca cca ggg atc cca ggc aat gtg tgg tcc     3843
 Pro Pro Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Asn Val Trp Ser
    1180                1185                1190

 agc atc agc gtg gag gac ctc tcg tct tac tta cat act gcc ggc ttg     3891
 Ser Ile Ser Val Glu Asp Leu Ser Ser Tyr Leu His Thr Ala Gly Leu
1195                1200                1205                1210

 tca ttc atc cca ggc cct cca gga cct cct ggt ccc cca ggg cct cga     3939
 Ser Phe Ile Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg
                1215                1220                1225

 ggg ccc ccg ggt gtc tca gga gcc ctg gca acc tat gca gct gaa aac     3987
 Gly Pro Pro Gly Val Ser Gly Ala Leu Ala Thr Tyr Ala Ala Glu Asn
            1230                1235                1240

 agc gac agc ttc cgg agc gag ctg atc agc tac ctc aca agt cct gat     4035
 Ser Asp Ser Phe Arg Ser Glu Leu Ile Ser Tyr Leu Thr Ser Pro Asp
        1245                1250                1255

 gtg cgc agc ttc att gtt ggc ccc cca ggc cct cct ggg ccg cag gga     4083
 Val Arg Ser Phe Ile Val Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly
    1260                1265                1270

 ccc cct ggg gac agc cgc ctc ctg tcc acg gat gcc tcc cac agt cgg     4131
 Pro Pro Gly Asp Ser Arg Leu Leu Ser Thr Asp Ala Ser His Ser Arg
1275                1280                1285                1290

 ggt agc agc tcc tcc tca cac agc tca tct gtc agg cgg ggc agc tcc     4179
 Gly Ser Ser Ser Ser Ser His Ser Ser Ser Val Arg Arg Gly Ser Ser
                1295                1300                1305

 tac agc tct tcc atg agc aca gga gga ggt ggt gca ggc tcc ctg ggt     4227
 Tyr Ser Ser Ser Met Ser Thr Gly Gly Gly Gly Ala Gly Ser Leu Gly
            1310                1315                1320

 gca ggc ggt gcc ttt ggt gaa gct gca gga gac agg ggt ccc tat ggc     4275
 Ala Gly Gly Ala Phe Gly Glu Ala Ala Gly Asp Arg Gly Pro Tyr Gly
        1325                1330                1335

 act gac atc ggc cca ggc gga ggc tat ggg gca gca gca gaa ggc ggc     4323
 Thr Asp Ile Gly Pro Gly Gly Gly Tyr Gly Ala Ala Ala Glu Gly Gly
    1340                1345                1350

 atg tat gct ggc aat ggc gga cta ttg gga gct gac ttt gct gga ggt     4371
 Met Tyr Ala Gly Asn Gly Gly Leu Leu Gly Ala Asp Phe Ala Gly Gly
1355                1360                1365                1370

 ctg gat tac aat gag ctg gct gtg agg gtg tca gag agc atg cag cgt     4419
 Leu Asp Tyr Asn Glu Leu Ala Val Arg Val Ser Glu Ser Met Gln Arg
                1375                1380                1385

 cag ggc cta ctg caa ggg atg gcc tac act gtc cag ggc cca cca ggc     4467
 Gln Gly Leu Leu Gln Gly Met Ala Tyr Thr Val Gln Gly Pro Pro Gly
            1390                1395                1400

 cag cct ggg cca cag ggg cca ccc ggc atc agc aag gtc ttc tct gcc     4515
 Gln Pro Gly Pro Gln Gly Pro Pro Gly Ile Ser Lys Val Phe Ser Ala
        1405                1410                1415

 tac agc aac gtg act gcg gac ctc atg gac ttc ttc caa act tat gga     4563
 Tyr Ser Asn Val Thr Ala Asp Leu Met Asp Phe Phe Gln Thr Tyr Gly
    1420                1425                1430

 gcc att caa gga ccc cct ggg caa aaa gga gag atg ggc act cca gga     4611
 Ala Ile Gln Gly Pro Pro Gly Gln Lys Gly Glu Met Gly Thr Pro Gly
1435                1440                1445                1450

 ccc aaa ggt gac agg ggc cct gct ggg cca cca ggt cat cct ggg cca     4659
 Pro Lys Gly Asp Arg Gly Pro Ala Gly Pro Pro Gly His Pro Gly Pro
                1455                1460                1465

 cct ggc cct cga gga cac aag gga gaa aaa gga gac aaa ggt gac caa     4707
 Pro Gly Pro Arg Gly His Lys Gly Glu Lys Gly Asp Lys Gly Asp Gln
            1470                1475                1480

 gtc tat gct ggg cgg aga agg aga aga agt att gct gtc aag ccg tga     4755
 Val Tyr Ala Gly Arg Arg Arg Arg Arg Ser Ile Ala Val Lys Pro 
        1485                1490                1495

 gctagccatg gcaggacagc tcctggacca ggtctcataa tgcatgtggc acttaggtcc   4815

 aaggtctcca gagggtgaaa gctggagtct gtcaatgtcc tactgagaca gcacagccaa   4875

 cctagctagc aacatttgtt ttagtctgaa caatatatac ttatagaatt cagtcaaaga   4935

 tacacaatct gaaacagctt catggggtgg actctaacag tagttgcaat gttttagaat   4995

 gagacttact tctctgctat ctagatctga actccttggc ttctttactt agttcaagcc   5055

 ccagcctagg aaagccagtt acataaaagt tggctcagga gtcttagagc tttacctaaa   5115

 tatgagccca gaaaacggag gatgggggtg gggcgccttc ctggaggtga cacttgatgg   5175

 gggtgtgttc tggttactgt tctaaggctg tgccatcagc tccttcctcc cctgttcatt   5235

 ctgcattctc tagtcagttg gctaagaagt gactcttgca actaaaaaaa ttaagaaatt   5295

 cacttcccct ctaggaggtg atgatagggt ttctaatggt tatatgtata tcacattccc   5355

 atttgcttag aaagtctgat tgtagctatg attgtccgta ggcccatact agagttcatg   5415

 gatatgttat actgaaccag gccagagcaa acagaaaaag aaggttgagg gcaatggaca   5475

 aggaaggaat aaagggagaa gagggaaaac agaaaacctg atgctgggga cacagcatca   5535

 gctcaagacg tcaccctcca ttctgcactc agaaaatggc acttggggga ctgggcgcag   5595

 ttggtcttta accacttttc aatgtctaaa aacatttgtt tgtggtctat aagatgaaac   5655

 atcatttcaa tcgtaaaatt tcccattaaa gaagtttttt tttctaataa aaaaaaaaa    5714




      <210> 169
      <211> 1587
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1146)..(1292)

      <400> 169
 cggccgcgtc gacctcacct gtcaaatggt aaataaccac tgtcctatgt agctggtaaa     60

 ctgatgagaa gacagacaac tttgtaatga ttggcgtttg tttggcattt tgtggatttc    120

 aaaacacttt tgacatcatt aattcattga accttaactg caatcttatg acttaggaaa    180

 tttccccaca atgtacagat gaggaaactg agagaggttg aggcttgttc atagtttcac    240

 agcttttgat taacaaaagt taggattata aatccaaatc ccgtgctctt attttgaaaa    300

 gtataaagat ggcaaccttt ctttctatcc cctacttagt ggcaaattat ccccttcccc    360

 ttttcacagt caccagaaat gcagagaatg tctgctgtgt ttgaaaagca gatctaagct    420

 gactggggag aaagaaagga gcttatttca ggtcttcttc aggctggact ctaaactttt    480

 aagatcatgt gcgcccgtgc tcccatcagc tcctgctgtt ccatctcatg ccatttacag    540

 agtgccattt actgagccac tacttcattg gctactcata gcaacttgtg gggtagacaa    600

 agtgcacttt acagatgggc aaactgaggt ccagagtccc tgaattgtac atgtcagaac    660

 caggattgaa tctagaagtc ttgggctcct gacaccaaac aggtgctctt aacttgcaga    720

 atgtaggttc ctttgattca gttcggttca aacaattctt gaatataacc catgtgccag    780

 agactttgct atgcaagaga gcctctagtt aggctcaaac cgtcttggtc tagtgcctta    840

 cttaagaaca gggacttgta ttatttactt ctctgtcccc aggcaggacc ttgatccaaa    900

 aatgctttgc tgttgttttt ggccttaatc tgccagaaac tagagggagc agatggccac    960

 agcaatgtgg gttatgagga tgtgatatca ggcagggttg aaggatgaat tgagagccct   1020

 gcacccaact acttctgtgt ctgtgcctag gcccttgtca gggtagtctc tatctgagag   1080

 tgtagctggt cagcctggtc ccatttctca tttccagtca cctccccctc ttgccatccc   1140

 atata    atg ggg tta gtc tcc tgg aca gat ctc ata cag agg ctg ctg    1187
          Met Gly Leu Val Ser Trp Thr Asp Leu Ile Gln Arg Leu Leu
            1               5                  10

 gga tct gct gtc caa atg acc ctt tgg acc tat ttc cca gcc atg ttc     1235
 Gly Ser Ala Val Gln Met Thr Leu Trp Thr Tyr Phe Pro Ala Met Phe
  15                  20                  25                  30

 caa gat gat ggt gag gag tct agc ccc aca gcc agt atg cta tct cta     1283
 Gln Asp Asp Gly Glu Glu Ser Ser Pro Thr Ala Ser Met Leu Ser Leu
                  35                  40                  45

 ttc aga taa ctcccag ctcacaggcc tcccaccagg ctctcaccca ctctgatgtt     1339
 Phe Arg 


 ttcactcctg actcctaaga agcagattgg caatttagtg tgagtctgtc agacagccta   1399

 gagagtaatc aatactgaga gaaatggaca tatttcctgt ttattcaaaa tcctgatgaa   1459

 aattttaagg agcactattt gggaagggat gactgggaac cttgcaagaa caaacagctt   1519

 aaaattcatg aacagaaata gcaacgttta ttcatgatgt ttcaaatgcc cctaatattc   1579

 acatcttt                                                            1587




      <210> 170
      <211> 1649
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(1538)

      <400> 170
 taagcttgcg gccgcggcgg cggcgcgggg cgctcgggct g    atg gcg gcg gcg      53
                                                  Met Ala Ala Ala
                                                    1

 gcc ggg ccc ggg gct gcg ctg tcc ccg cgg ccg tgc gac agc gac cca      101
 Ala Gly Pro Gly Ala Ala Leu Ser Pro Arg Pro Cys Asp Ser Asp Pro
   5                  10                  15                  20

 gcc acc ccc gga gcg cag tcc ccg aag gat gat aat gaa gat aat tca      149
 Ala Thr Pro Gly Ala Gln Ser Pro Lys Asp Asp Asn Glu Asp Asn Ser
                  25                  30                  35

 aat gat ggg acc cag cca tcc aaa agg agg cga atg ggc tca gga gat      197
 Asn Asp Gly Thr Gln Pro Ser Lys Arg Arg Arg Met Gly Ser Gly Asp
              40                  45                  50

 agt tct agg agt tgt gaa act tca agt caa gat ctt ggt ttt agt tac      245
 Ser Ser Arg Ser Cys Glu Thr Ser Ser Gln Asp Leu Gly Phe Ser Tyr
          55                  60                  65

 tat cca gca gaa aac ttg ata gag tac aaa tgg cca cct gat gaa aca      293
 Tyr Pro Ala Glu Asn Leu Ile Glu Tyr Lys Trp Pro Pro Asp Glu Thr
      70                  75                  80

 gga gaa tac tat atg ctt caa gaa caa gtc agt gaa tat ttg ggt gtg      341
 Gly Glu Tyr Tyr Met Leu Gln Glu Gln Val Ser Glu Tyr Leu Gly Val
  85                  90                  95                 100

 acc tcc ttt aaa agg aaa tat cca gat tta gag cga cga gat ttg tct      389
 Thr Ser Phe Lys Arg Lys Tyr Pro Asp Leu Glu Arg Arg Asp Leu Ser
                 105                 110                 115

 cac aag gag aaa ctc tac ctg aga gag cta aat gtc att act gaa act      437
 His Lys Glu Lys Leu Tyr Leu Arg Glu Leu Asn Val Ile Thr Glu Thr
             120                 125                 130

 cag tgc act cta ggc tta aca gca ttg cgc agt gat gaa gtg att gat      485
 Gln Cys Thr Leu Gly Leu Thr Ala Leu Arg Ser Asp Glu Val Ile Asp
         135                 140                 145

 tta atg ata aaa gaa tat cca gcc aaa cat gct gag tat tct gtt att      533
 Leu Met Ile Lys Glu Tyr Pro Ala Lys His Ala Glu Tyr Ser Val Ile
     150                 155                 160

 cta caa gaa aaa gaa cgt caa cga att aca gac cat tat aaa gag tat      581
 Leu Gln Glu Lys Glu Arg Gln Arg Ile Thr Asp His Tyr Lys Glu Tyr
 165                 170                 175                 180

 tcc caa atg caa caa cag aat act cag aaa gtt gaa gcc agt aaa gtg      629
 Ser Gln Met Gln Gln Gln Asn Thr Gln Lys Val Glu Ala Ser Lys Val
                 185                 190                 195

 cct gag tat att aag aaa gct gcc aaa aaa gca gca gaa ttt aat agc      677
 Pro Glu Tyr Ile Lys Lys Ala Ala Lys Lys Ala Ala Glu Phe Asn Ser
             200                 205                 210

 aac tta aac cgg gaa cgc atg gaa gaa aga aga gct tat ttt gac ttg      725
 Asn Leu Asn Arg Glu Arg Met Glu Glu Arg Arg Ala Tyr Phe Asp Leu
         215                 220                 225

 cag aca cat gtt atc cag gta cct caa ggg aag tac aaa gtt ttg cca      773
 Gln Thr His Val Ile Gln Val Pro Gln Gly Lys Tyr Lys Val Leu Pro
     230                 235                 240

 aca gag cga aca aag gtc agt tct tac cca gtg gct ctc atc ccc gga      821
 Thr Glu Arg Thr Lys Val Ser Ser Tyr Pro Val Ala Leu Ile Pro Gly
 245                 250                 255                 260

 cag ttc cag gaa tat tat aag agg tac tca cca gat gag ctg cgg tat      869
 Gln Phe Gln Glu Tyr Tyr Lys Arg Tyr Ser Pro Asp Glu Leu Arg Tyr
                 265                 270                 275

 ctg cca tta aac aca gcc ctg tat gag ccc cct ttg gat cct gag ctc      917
 Leu Pro Leu Asn Thr Ala Leu Tyr Glu Pro Pro Leu Asp Pro Glu Leu
             280                 285                 290

 cct gct cta gac agt gat ggt gat tca gat gat ggc gaa gat ggt cga      965
 Pro Ala Leu Asp Ser Asp Gly Asp Ser Asp Asp Gly Glu Asp Gly Arg
         295                 300                 305

 ggt gat gag aaa cgg aaa aat aaa ggc act tcg gac agc tcc tct ggc     1013
 Gly Asp Glu Lys Arg Lys Asn Lys Gly Thr Ser Asp Ser Ser Ser Gly
     310                 315                 320

 aat gta tct gaa ggg gaa agc cct cct gac agc cag gag gac tct ttc     1061
 Asn Val Ser Glu Gly Glu Ser Pro Pro Asp Ser Gln Glu Asp Ser Phe
 325                 330                 335                 340

 cag gga aga cag aaa tca aaa gac aaa gct gcc act cca aga aaa gat     1109
 Gln Gly Arg Gln Lys Ser Lys Asp Lys Ala Ala Thr Pro Arg Lys Asp
                 345                 350                 355

 ggt ccc aaa cgt tct gta ctg tcc aag tca gtt cct ggg tac aag cca     1157
 Gly Pro Lys Arg Ser Val Leu Ser Lys Ser Val Pro Gly Tyr Lys Pro
             360                 365                 370

 aag gtc att cca aat gct ata tgt gga att tgt ctg aag ggt aag gag     1205
 Lys Val Ile Pro Asn Ala Ile Cys Gly Ile Cys Leu Lys Gly Lys Glu
         375                 380                 385

 tcc aac aag aaa gga aag gct gaa tca ctt ata cac tgc tcc caa tgt     1253
 Ser Asn Lys Lys Gly Lys Ala Glu Ser Leu Ile His Cys Ser Gln Cys
     390                 395                 400

 gag aat agt ggc cat cct tct tgc ctg gat atg aca atg gag ctt gtt     1301
 Glu Asn Ser Gly His Pro Ser Cys Leu Asp Met Thr Met Glu Leu Val
 405                 410                 415                 420

 tct atg att aag acc tac cca tgg cag tgt atg gaa tgt aaa aca tgc     1349
 Ser Met Ile Lys Thr Tyr Pro Trp Gln Cys Met Glu Cys Lys Thr Cys
                 425                 430                 435

 att ata tgt gga caa ccc cac cat gaa gaa gaa atg atg ttc tgt gat     1397
 Ile Ile Cys Gly Gln Pro His His Glu Glu Glu Met Met Phe Cys Asp
             440                 445                 450

 atg tgt gac aga ggt tat cat act ttt tgt gtg ggc ctt ggt gct att     1445
 Met Cys Asp Arg Gly Tyr His Thr Phe Cys Val Gly Leu Gly Ala Ile
         455                 460                 465

 cca tca ggt cgc tgg att tgt gac tgt tgt cag cgg gcc ccc cca aca     1493
 Pro Ser Gly Arg Trp Ile Cys Asp Cys Cys Gln Arg Ala Pro Pro Thr
     470                 475                 480

 ccc agg aaa gtg ggc aga agg ggg aaa aac agc aaa gag gga taa aat     1541
 Pro Arg Lys Val Gly Arg Arg Gly Lys Asn Ser Lys Glu Gly 
 485                 490                 495

 agtttttgac tctaatactg tatatgcatt taagtggaat atttggtgcc atttacaaca   1601

 ttattttcat gccaataaaa gatttttttt gcaaattaaa aaaaaaaa                1649




      <210> 171
      <211> 831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(378)

      <400> 171
 taaaaaccaa aggaatgacc aatgagagcc acagtcccta ggaagaactg taaatgaaga     60

 cgaatccac    atg gca cag gat ttc tcc caa cat cct caa acg gga atc     108
              Met Ala Gln Asp Phe Ser Gln His Pro Gln Thr Gly Ile
                1               5                  10

 atc cga agg cat cga ttc tac agc cca aag cct ttg tcc aca act ccc      156
 Ile Arg Arg His Arg Phe Tyr Ser Pro Lys Pro Leu Ser Thr Thr Pro
      15                  20                  25

 agg ggt cag agc ttc ctt ctt tcg cgc cag gcc aaa gtt gct acg tgg      204
 Arg Gly Gln Ser Phe Leu Leu Ser Arg Gln Ala Lys Val Ala Thr Trp
  30                  35                  40                  45

 gat ccg atg ttg tcg cca gac ttt cag cca aaa tca gcc ttc aaa tta      252
 Asp Pro Met Leu Ser Pro Asp Phe Gln Pro Lys Ser Ala Phe Lys Leu
                  50                  55                  60

 acc tgg acc gcc caa cct ccg tgc ctt tcc gtt acg ccg tct caa ggg      300
 Thr Trp Thr Ala Gln Pro Pro Cys Leu Ser Val Thr Pro Ser Gln Gly
              65                  70                  75

 caa aca ttc cac cct aac tcg cca gag ggt gaa ctg ccc cca gat cta      348
 Gln Thr Phe His Pro Asn Ser Pro Glu Gly Glu Leu Pro Pro Asp Leu
          80                  85                  90

 act gaa aac act tgc cct tct caa gcc taa c gagctgggcc tgcagcgctt      399
 Thr Glu Asn Thr Cys Pro Ser Gln Ala 
      95                 100

 ttctgccacc actgactacg atgacatagc aaagaaaaaa atatacctat gaaatccttc    459

 gagatcttca ctctcaagat ccctgggaag cgcacataca ccaccacatg gaagctgacg    519

 ggaaaggaag agtcggtgtt ttagcaagaa aagagggtgc cctaacggca ggagctacgc    579

 tagatactgg cgcggccgcc ggtcccgcct ttccccgttc ttccggcttg gtcgcccagc    639

 cctccccacc cccggcgccc cgaggggaac tgcttcgcac ttggcaataa acacacacca    699

 ctgctgccga gtcggacaca caaggccgga ggctgaggga actctttgtc gcagcagcct    759

 ccccaaaaca ggtagaccct cagtgagccc agaaggtcga cgcggcagcg aattcggatc    819

 ctcgagagat ct                                                        831




      <210> 172
      <211> 1906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (225)..(1088)

      <400> 172
 ggtaccggtc cggaattccc gggtcgaatt cgcggtcgaa cgatttcgtt tcccgggtcg     60

 acgatttcgt gtgaggttgt tgctccttca gcgcctatcg ctggctcttg gggcgcagag    120

 aggggccgca gtctccgcgg ctgcgtcgag ctcccttgca gtcccctcca tgttccccgg    180

 cgccactact ccccttccta aggccgccgc ttaccccggg gtct atg gaa gta atg     236
                                                  Met Glu Val Met
                                                    1

 gaa gga ccc ctc aac ctg gct cat caa cag agc aga cga gca gac cgt      284
 Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg Arg Ala Asp Arg
   5                  10                  15                  20

 tta tta gct gca ggc aaa tac gaa gag gct att tct tgt cac aaa aag      332
 Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser Cys His Lys Lys
                  25                  30                  35

 gct gca gca tat ctt tct gaa gcc atg aag ctg aca cag tca gag cag      380
 Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr Gln Ser Glu Gln
              40                  45                  50

 gct cat ctt tca ctg gaa ttg caa agg gat agc cat atg aaa cag ctc      428
 Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His Met Lys Gln Leu
          55                  60                  65

 ctc ctc atc caa gag aga tgg aaa agg gcc cag cgt gaa gaa aga ttg      476
 Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg Glu Glu Arg Leu
      70                  75                  80

 aaa gcc cag cag aac aca gac aag gat gca gct gcc cat ctt cag aca      524
 Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala His Leu Gln Thr
  85                  90                  95                 100

 tct cac aaa ccc tct gca gag gat gca gag ggc cag agt ccc ctt tct      572
 Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln Ser Pro Leu Ser
                 105                 110                 115

 cag aag tac agc cct tcc aca gag aaa tgc ctg cct gag att cag ggg      620
 Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro Glu Ile Gln Gly
             120                 125                 130

 atc ttt gac agg gat cca gac aca cta ctt tat tta ctt cag caa aag      668
 Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu Leu Gln Gln Lys
         135                 140                 145

 agt gag cca gca gag cca tgt att gga agc aaa gcc cca aaa gat gat      716
 Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala Pro Lys Asp Asp
     150                 155                 160

 aaa aca att ata gag gag cag gca acc aaa att gca gat ttg aag agg      764
 Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala Asp Leu Lys Arg
 165                 170                 175                 180

 cat gtg gaa ttc ctt gtg gct gag aat gaa aga tta agg aaa gaa aat      812
 His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu Arg Lys Glu Asn
                 185                 190                 195

 aaa caa cta aag gct gaa aag gcc aga ctt cta aaa ggt cca ata gaa      860
 Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys Gly Pro Ile Glu
             200                 205                 210

 aag gag ctg gat gta gat gct gat ttt gta gaa acg tca gag tta tgg      908
 Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr Ser Glu Leu Trp
         215                 220                 225

 agc ttg cca cca cat gca gaa act gct aca gcc tcc tca acc tgg cag      956
 Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser Ser Thr Trp Gln
     230                 235                 240

 aag ttc gca gca aat act ggg aaa gcc aag gac att cca atc ccc aat     1004
 Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile Pro Ile Pro Asn
 245                 250                 255                 260

 ctt cct ccc ttg gat ttt cca tct cca gaa ctt cct ctt atg gag ctc     1052
 Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro Leu Met Glu Leu
                 265                 270                 275

 tct gag gat att ctg aaa gga ttt atg aat aat taa aatg gaaggccaca     1102
 Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn 
             280                 285

 gaaaagggga aaagaggaaa taataacagt aatcgttaat ccagcaaaaa gaaatgaaaa   1162

 gggaaaacca catagaaggg taatcccgga aatgcttcat ctggtggact gtgggagcag   1222

 aggcattgcc aggacttggg aaacagtcac tgtgaaatgc gctgcgtatc tcattcactc   1282

 acttcagcta atgattccga cttggcagac gctaaactca tggaggttcg gtttctcctg   1342

 atacaaacca aatggctacc tggaagaatt tctttcaagc aacagttatt tttcttatct   1402

 tcagggttaa aatgtataaa agttatgtgt aattaatcta taatgccata aatgataatg   1462

 caaaacctaa ataatatggt ggccggaggg gctgccttat atttgaaaca tgctttctat   1522

 catgcattga ctgtatgcat tttgttaatg cacattctgt ttgtttaagg tgtgtaagat   1582

 acacaccctt ctagatgaaa ctatatgtgc cacactttgc actactcata atgataacct   1642

 caagactatc agaagaaata tttaaatttc cattttatga agaaaggaac caaattatta   1702

 tgctttttaa aacaaattac cagtttacat aattaatcag ggtgcatttt aagttctaac   1762

 ttcgtttatt gtataatgca tcatttgaaa ataccaagga ggaaataccc tttgttttta   1822

 atgatgcaag agtggacgta atgctagttg gcagtatttt attgtaagaa atcaataaag   1882

 taattgtgtt ttaaaaaaaa aaaa                                          1906




      <210> 173
      <211> 3784
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(3082)

      <400> 173
 agcaattcga gtctatgtcc taaatcaaaa tgatccttca ttgaccagtt tggtggacta     60

 ctggcacttc aat   atg cat gac aat aat tat gga tgt att aaa agt att     109
                  Met His Asp Asn Asn Tyr Gly Cys Ile Lys Ser Ile
                    1               5                  10

 gct aat agc ttt gat gat cgt ttc ttg gtg act gct gga gca gat ggc      157
 Ala Asn Ser Phe Asp Asp Arg Phe Leu Val Thr Ala Gly Ala Asp Gly
          15                  20                  25

 aat atc ttt gtt ttc aac att ttt tct gaa ttt atg cta agg aaa gac      205
 Asn Ile Phe Val Phe Asn Ile Phe Ser Glu Phe Met Leu Arg Lys Asp
      30                  35                  40

 atg aag gcc aaa gtt cca tct ccc agg ttt gga att gaa aca gag cca      253
 Met Lys Ala Lys Val Pro Ser Pro Arg Phe Gly Ile Glu Thr Glu Pro
  45                  50                  55                  60

 att cca gaa gac att gaa gat ccc aaa gcc tac agt atc gag aat gct      301
 Ile Pro Glu Asp Ile Glu Asp Pro Lys Ala Tyr Ser Ile Glu Asn Ala
                  65                  70                  75

 agg aga aaa aga gaa cat gac aag tta atg aaa gaa gtg gga gaa ata      349
 Arg Arg Lys Arg Glu His Asp Lys Leu Met Lys Glu Val Gly Glu Ile
              80                  85                  90

 aag gca cgg aag aga gag caa atc aaa gct ttg agg agt gaa ttt tgt      397
 Lys Ala Arg Lys Arg Glu Gln Ile Lys Ala Leu Arg Ser Glu Phe Cys
          95                 100                 105

 aat cta tta gaa atg aat gaa aaa tta cca aag cat atg cag ttt aaa      445
 Asn Leu Leu Glu Met Asn Glu Lys Leu Pro Lys His Met Gln Phe Lys
     110                 115                 120

 cga aca gat ttt gat gta gat tcc caa atc cgt gct gag atg cac aga      493
 Arg Thr Asp Phe Asp Val Asp Ser Gln Ile Arg Ala Glu Met His Arg
 125                 130                 135                 140

 aaa aca gct ttc aaa att caa caa gtg gaa aag gaa tta gct tgg gaa      541
 Lys Thr Ala Phe Lys Ile Gln Gln Val Glu Lys Glu Leu Ala Trp Glu
                 145                 150                 155

 aaa gag aaa cat gaa ctc ggc cta atg aag cta aag aat cga ttt cga      589
 Lys Glu Lys His Glu Leu Gly Leu Met Lys Leu Lys Asn Arg Phe Arg
             160                 165                 170

 gat cca ctg gaa agt gat act att gtg gtt cat gcc ata ctg agt gac      637
 Asp Pro Leu Glu Ser Asp Thr Ile Val Val His Ala Ile Leu Ser Asp
         175                 180                 185

 cac aag ata tcc tct tac agg ctg gtg cag ccc tct aag tac tcc aaa      685
 His Lys Ile Ser Ser Tyr Arg Leu Val Gln Pro Ser Lys Tyr Ser Lys
     190                 195                 200

 ttc aaa cga gct agt caa tca gag aga aaa cca agc aaa ttg gac agg      733
 Phe Lys Arg Ala Ser Gln Ser Glu Arg Lys Pro Ser Lys Leu Asp Arg
 205                 210                 215                 220

 ttt gaa aaa gag gga cct gga aga aag gac agc cag aga gat gca ggt      781
 Phe Glu Lys Glu Gly Pro Gly Arg Lys Asp Ser Gln Arg Asp Ala Gly
                 225                 230                 235

 ggg agt gtt acc ata caa gaa gaa tca ata ata gaa aaa ggg aag aaa      829
 Gly Ser Val Thr Ile Gln Glu Glu Ser Ile Ile Glu Lys Gly Lys Lys
             240                 245                 250

 ttt cgg cct aaa acc cta agt gaa atc atc gtg gaa aat caa att gag      877
 Phe Arg Pro Lys Thr Leu Ser Glu Ile Ile Val Glu Asn Gln Ile Glu
         255                 260                 265

 aaa acg aga aaa ctt ata tta aaa gct gaa agg gca caa cta aag att      925
 Lys Thr Arg Lys Leu Ile Leu Lys Ala Glu Arg Ala Gln Leu Lys Ile
     270                 275                 280

 caa cag cga aaa aaa gaa tgg gag gaa cta tac aag agt aaa cct ggt      973
 Gln Gln Arg Lys Lys Glu Trp Glu Glu Leu Tyr Lys Ser Lys Pro Gly
 285                 290                 295                 300

 gat gac tat gaa gat ccc aaa gat ctt caa gcc atc aaa gaa gcc cag     1021
 Asp Asp Tyr Glu Asp Pro Lys Asp Leu Gln Ala Ile Lys Glu Ala Gln
                 305                 310                 315

 gtg tat atg gga gat ttc aat ctg aag aca gcc cca gac tac aag ata     1069
 Val Tyr Met Gly Asp Phe Asn Leu Lys Thr Ala Pro Asp Tyr Lys Ile
             320                 325                 330

 cct gag cac atg aga ata aat gct gcc aag aag gaa gag gaa cta gga     1117
 Pro Glu His Met Arg Ile Asn Ala Ala Lys Lys Glu Glu Glu Leu Gly
         335                 340                 345

 cac cta gat tct ttg gtc cat gga aat aaa agg cac atg aac aag tgc     1165
 His Leu Asp Ser Leu Val His Gly Asn Lys Arg His Met Asn Lys Cys
     350                 355                 360

 att ctc tct ctt aga gac ctt aaa gtg gct gtt gtt gag gaa ata cag     1213
 Ile Leu Ser Leu Arg Asp Leu Lys Val Ala Val Val Glu Glu Ile Gln
 365                 370                 375                 380

 tgc ctg gta caa gaa ctg aag aac att cag tcg act ctt cac ata tcc     1261
 Cys Leu Val Gln Glu Leu Lys Asn Ile Gln Ser Thr Leu His Ile Ser
                 385                 390                 395

 aag cac ata ccc att ccc aaa att cct cag ata cac cca gaa gaa gtt     1309
 Lys His Ile Pro Ile Pro Lys Ile Pro Gln Ile His Pro Glu Glu Val
             400                 405                 410

 cca gaa aag aga ttt cag tat gat gaa gaa act ctc cta aat ttt aag     1357
 Pro Glu Lys Arg Phe Gln Tyr Asp Glu Glu Thr Leu Leu Asn Phe Lys
         415                 420                 425

 caa cag caa atg aaa agt aaa gat gaa aag tcc ccc gga gtg gaa cag     1405
 Gln Gln Gln Met Lys Ser Lys Asp Glu Lys Ser Pro Gly Val Glu Gln
     430                 435                 440

 aca ggg tct gga ggc cca gtt gga gga ttc ctc aaa ctc tct tct aga     1453
 Thr Gly Ser Gly Gly Pro Val Gly Gly Phe Leu Lys Leu Ser Ser Arg
 445                 450                 455                 460

 aag gat ggg gat ttg aca acc cgt gat tca ata tct aga tca tca aag     1501
 Lys Asp Gly Asp Leu Thr Thr Arg Asp Ser Ile Ser Arg Ser Ser Lys
                 465                 470                 475

 gca tca aca ttc agc cta gat ata cca aag tgt ttg gaa ttt gaa aaa     1549
 Ala Ser Thr Phe Ser Leu Asp Ile Pro Lys Cys Leu Glu Phe Glu Lys
             480                 485                 490

 gca gag cca acg gat gtg gag ctg gaa att atg aag aga gac gag att     1597
 Ala Glu Pro Thr Asp Val Glu Leu Glu Ile Met Lys Arg Asp Glu Ile
         495                 500                 505

 aaa cac gtg tac atg caa cag tat ttg gtc aac agg atc aaa gaa ctg     1645
 Lys His Val Tyr Met Gln Gln Tyr Leu Val Asn Arg Ile Lys Glu Leu
     510                 515                 520

 gtt gtc act ttc gat gca gaa ctc cgt ctc ctt aga cat cag aaa cta     1693
 Val Val Thr Phe Asp Ala Glu Leu Arg Leu Leu Arg His Gln Lys Leu
 525                 530                 535                 540

 aaa cta gat act cag atg aaa tta tct gac ctg cac cat gtc acc tta     1741
 Lys Leu Asp Thr Gln Met Lys Leu Ser Asp Leu His His Val Thr Leu
                 545                 550                 555

 ttt caa gaa ata ctt ctc ctg aag aat ttt gaa aaa cag gag aac ata     1789
 Phe Gln Glu Ile Leu Leu Leu Lys Asn Phe Glu Lys Gln Glu Asn Ile
             560                 565                 570

 ctt caa gaa cgt gtt aat tcc tta gac aaa gag gaa cag tac atg caa     1837
 Leu Gln Glu Arg Val Asn Ser Leu Asp Lys Glu Glu Gln Tyr Met Gln
         575                 580                 585

 tgg aaa ata aat gaa act ctt aaa gag atg gaa gag aaa aag aat gaa     1885
 Trp Lys Ile Asn Glu Thr Leu Lys Glu Met Glu Glu Lys Lys Asn Glu
     590                 595                 600

 atc acc aaa ctc cag gag caa gaa aag gca ctc tat gct ggt ttt caa     1933
 Ile Thr Lys Leu Gln Glu Gln Glu Lys Ala Leu Tyr Ala Gly Phe Gln
 605                 610                 615                 620

 gca gcc att gga gaa aac aat aaa ttt gca aac ttc ctc atg aag gtc     1981
 Ala Ala Ile Gly Glu Asn Asn Lys Phe Ala Asn Phe Leu Met Lys Val
                 625                 630                 635

 cta aag aag aag att aaa cgg gta aag aaa aaa gaa gtt gaa gga gat     2029
 Leu Lys Lys Lys Ile Lys Arg Val Lys Lys Lys Glu Val Glu Gly Asp
             640                 645                 650

 gct gat gaa gat gag gag agt gag gaa tca agt gaa gaa gaa tct agc     2077
 Ala Asp Glu Asp Glu Glu Ser Glu Glu Ser Ser Glu Glu Glu Ser Ser
         655                 660                 665

 ttg gag agt gat gaa gat gag tct gaa tca gaa gat gag gtt ttt gat     2125
 Leu Glu Ser Asp Glu Asp Glu Ser Glu Ser Glu Asp Glu Val Phe Asp
     670                 675                 680

 gat tct att tgc cca aca aat tgt gat gtg gct ctt ttt gag ctg gcc     2173
 Asp Ser Ile Cys Pro Thr Asn Cys Asp Val Ala Leu Phe Glu Leu Ala
 685                 690                 695                 700

 ctt cac ctt cga gag aaa agg ctg gac att gag gag gct tta gtt gaa     2221
 Leu His Leu Arg Glu Lys Arg Leu Asp Ile Glu Glu Ala Leu Val Glu
                 705                 710                 715

 gaa aag aaa att gtt gat aac ctc aaa aag gaa tat gat aca ttg tca     2269
 Glu Lys Lys Ile Val Asp Asn Leu Lys Lys Glu Tyr Asp Thr Leu Ser
             720                 725                 730

 aaa aaa gtg aaa att gtg gca act aat ctg aat gca gca gag gag gcc     2317
 Lys Lys Val Lys Ile Val Ala Thr Asn Leu Asn Ala Ala Glu Glu Ala
         735                 740                 745

 ctg gag gct tat cag cga gag aag cag cag cgg ctg aat gaa ctg cta     2365
 Leu Glu Ala Tyr Gln Arg Glu Lys Gln Gln Arg Leu Asn Glu Leu Leu
     750                 755                 760

 gtt gtg att ccg ctc aag ccc cac cag ata gag tat gtg gta ttt gga     2413
 Val Val Ile Pro Leu Lys Pro His Gln Ile Glu Tyr Val Val Phe Gly
 765                 770                 775                 780

 gaa ata cct agc gat ctt tct ggt act ttg gtc ttc tct aac cat gcc     2461
 Glu Ile Pro Ser Asp Leu Ser Gly Thr Leu Val Phe Ser Asn His Ala
                 785                 790                 795

 ttg aga cgg ctg caa gaa cga atc cgt gag ctc cag gag gaa aat tcc     2509
 Leu Arg Arg Leu Gln Glu Arg Ile Arg Glu Leu Gln Glu Glu Asn Ser
             800                 805                 810

 aag cag caa aaa ctt aac aaa gaa tgg aga gag aga cgt aaa cag ctc     2557
 Lys Gln Gln Lys Leu Asn Lys Glu Trp Arg Glu Arg Arg Lys Gln Leu
         815                 820                 825

 atc cga gaa aag aga gaa atg aca aaa acc ata cac aaa atg gag gaa     2605
 Ile Arg Glu Lys Arg Glu Met Thr Lys Thr Ile His Lys Met Glu Glu
     830                 835                 840

 aca gtc cgg cag ctc atg atc agc aag ttt ggc cgt gtg gta aat cta     2653
 Thr Val Arg Gln Leu Met Ile Ser Lys Phe Gly Arg Val Val Asn Leu
 845                 850                 855                 860

 gaa gcc ctt caa atg ctt tct gtt aat aca aca ctt gaa gaa ctg aag     2701
 Glu Ala Leu Gln Met Leu Ser Val Asn Thr Thr Leu Glu Glu Leu Lys
                 865                 870                 875

 atc aga aaa ctt cga aag gag cta gca aat gcg aaa gag atg aag atg     2749
 Ile Arg Lys Leu Arg Lys Glu Leu Ala Asn Ala Lys Glu Met Lys Met
             880                 885                 890

 tgg gag gaa aag att gct caa atg cga tgg gaa ctg atg atg aag aca     2797
 Trp Glu Glu Lys Ile Ala Gln Met Arg Trp Glu Leu Met Met Lys Thr
         895                 900                 905

 aaa gaa cac acc aga aag ctt tat cag atg aat gat ttg tgt att gaa     2845
 Lys Glu His Thr Arg Lys Leu Tyr Gln Met Asn Asp Leu Cys Ile Glu
     910                 915                 920

 aag aag aaa ctt gat tct cgg ttg aat aca cta cag aat cag cag ggc     2893
 Lys Lys Lys Leu Asp Ser Arg Leu Asn Thr Leu Gln Asn Gln Gln Gly
 925                 930                 935                 940

 aat gcc ttc cag ggc cct cgg gaa gca gat gtt gtg gca aga gag gag     2941
 Asn Ala Phe Gln Gly Pro Arg Glu Ala Asp Val Val Ala Arg Glu Glu
                 945                 950                 955

 gtc act gaa ttg atc caa ctc cag gcg gaa agg att tcg gcc tta aag     2989
 Val Thr Glu Leu Ile Gln Leu Gln Ala Glu Arg Ile Ser Ala Leu Lys
             960                 965                 970

 gag gag att gct ctt ttg cgt agg aaa ggc ggt ctt atc ctc cca ccc     3037
 Glu Glu Ile Ala Leu Leu Arg Arg Lys Gly Gly Leu Ile Leu Pro Pro
         975                 980                 985

 att cag tct cca cga gag aaa gag ata cag ccc gca gac ctt tga gtt     3085
 Ile Gln Ser Pro Arg Glu Lys Glu Ile Gln Pro Ala Asp Leu 
     990                 995                1000

 tgctattttc tcaaacccat acaagatttc tgacataact cactggaagt tctgtctcct   3145

 catcacctcc aacaatctta ttactttaaa ctgaactcgc ctgaaagtgt aaaaccagat   3205

 ccagtcacgt taagtcactt taagaatctc tctacaattt ggttatctta gaactgactg   3265

 cagcacccaa cctctgttat gaaactgaat cattttagat gtttcgaacc tactagattg   3325

 aatatgaagt ctcggaaggc tgtgtttcat gattgcagca aatcacctgt aatatatttt   3385

 gttttaggaa aatttgattt gggggtatcc tgaattttta gcccttggca agaaaaacta   3445

 tcattcagca attcatgaga aaactttgtt ttcttgatcc ttagaaaata aacttagatg   3505

 ttattaagtg ttctctgaga ggatgcagga gaaaaggaca ttttgtcagc tatatcttag   3565

 aatagaaatg caaatttcag ttttggcatt gttgacttca taaagcagtg ttttgagggc   3625

 tcaggattca ggaaatacaa acagacatgg cagagcagtt tgctttgggt tggcagaaag   3685

 caggaaaata accagccttc ttggattgcc cacagttttt gtagactcct cagttctgag   3745

 tggagcagag gggcatgctt aataaaacag tcaataaag                          3784




      <210> 174
      <211> 2139
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(1821)

      <400> 174
 gaattcccgg gtcgacgatt tcgtggccgg ccggcgagac tgcacctccc agcatgcctt     60

 gcagccagga ctggagtcgg tacttaagag tgatggggtt ccctagatac tttaggccgt    120

 cgcatcgatt atagagattg aggtggaacc cggggcctgg gaactggacg cacgcggagg    180

 gcgaag   atg gaa gcc tgg cgc tgt gtg agg aag ggc tac ggc cac tgt     228
          Met Glu Ala Trp Arg Cys Val Arg Lys Gly Tyr Gly His Cys
            1               5                  10

 gtg gtg gga aga ggc cga tac ccc atg ttt ccc cat cac tcg agg agt      276
 Val Val Gly Arg Gly Arg Tyr Pro Met Phe Pro His His Ser Arg Ser
  15                  20                  25                  30

 ctg ggc aga gac tgg act aca ccg tgg gag aat ctg caa agg tgt tgc      324
 Leu Gly Arg Asp Trp Thr Thr Pro Trp Glu Asn Leu Gln Arg Cys Cys
                  35                  40                  45

 tgg aac aga cat att tct agt tgt atg agg tgg cct gga cat tac tct      372
 Trp Asn Arg His Ile Ser Ser Cys Met Arg Trp Pro Gly His Tyr Ser
              50                  55                  60

 cga gct cct tac cca tac ttc agt agt agg cat ttt tca cta aat tgg      420
 Arg Ala Pro Tyr Pro Tyr Phe Ser Ser Arg His Phe Ser Leu Asn Trp
          65                  70                  75

 aga cca ccc tgt ttg ttt gag tct aga act cag ttc cag tac tgt aac      468
 Arg Pro Pro Cys Leu Phe Glu Ser Arg Thr Gln Phe Gln Tyr Cys Asn
      80                  85                  90

 tgg aga cct gac aac ctg agc cag aca tct ttg att cat ctc tct agt      516
 Trp Arg Pro Asp Asn Leu Ser Gln Thr Ser Leu Ile His Leu Ser Ser
  95                 100                 105                 110

 tac gtc atg aac gct gag gga gat gag cct tca tca aaa cga aga aaa      564
 Tyr Val Met Asn Ala Glu Gly Asp Glu Pro Ser Ser Lys Arg Arg Lys
                 115                 120                 125

 cac caa ggt gtg ata aag cgg aat tgg gaa tat ata tgt agc cat gat      612
 His Gln Gly Val Ile Lys Arg Asn Trp Glu Tyr Ile Cys Ser His Asp
             130                 135                 140

 aaa gaa aaa acg aag atc cta gga gac aaa aat gtt gat ccc aaa tgt      660
 Lys Glu Lys Thr Lys Ile Leu Gly Asp Lys Asn Val Asp Pro Lys Cys
         145                 150                 155

 gaa gac agt gag aac aag ttt gac ttt tca gtg atg tcc tat aat ata      708
 Glu Asp Ser Glu Asn Lys Phe Asp Phe Ser Val Met Ser Tyr Asn Ile
     160                 165                 170

 ctt tca caa gat tta ctg gaa gat aac tct cac ctt tat aga cat tgc      756
 Leu Ser Gln Asp Leu Leu Glu Asp Asn Ser His Leu Tyr Arg His Cys
 175                 180                 185                 190

 cgg cgg cca gta tta cac tgg agt ttt agg ttt ccc aat att ctg aaa      804
 Arg Arg Pro Val Leu His Trp Ser Phe Arg Phe Pro Asn Ile Leu Lys
                 195                 200                 205

 gaa att aaa cat ttt gat gca gac gta ctt tgt ttg caa gaa gtt caa      852
 Glu Ile Lys His Phe Asp Ala Asp Val Leu Cys Leu Gln Glu Val Gln
             210                 215                 220

 gaa gat cat tat gga gca gag atc agg cca agt ttg gaa tca ctg ggt      900
 Glu Asp His Tyr Gly Ala Glu Ile Arg Pro Ser Leu Glu Ser Leu Gly
         225                 230                 235

 tat cac tgt gaa tat aag atg cgg aca gga agg aaa cct gat ggc tgt      948
 Tyr His Cys Glu Tyr Lys Met Arg Thr Gly Arg Lys Pro Asp Gly Cys
     240                 245                 250

 gct att tgc ttc aaa cat tcc aaa ttt tca ctc ttg tca gtg aac cca      996
 Ala Ile Cys Phe Lys His Ser Lys Phe Ser Leu Leu Ser Val Asn Pro
 255                 260                 265                 270

 gtg gaa ttc ttc cgc cct gat att tct ctg ttg gac aga gac aat gtt     1044
 Val Glu Phe Phe Arg Pro Asp Ile Ser Leu Leu Asp Arg Asp Asn Val
                 275                 280                 285

 gga tta gtt tta ctc tta cag ccc aaa att cca tat gct gcc tgc cct     1092
 Gly Leu Val Leu Leu Leu Gln Pro Lys Ile Pro Tyr Ala Ala Cys Pro
             290                 295                 300

 gca atc tgc gta gca aat acg cat ctg ttg tat aat cca agg cga ggt     1140
 Ala Ile Cys Val Ala Asn Thr His Leu Leu Tyr Asn Pro Arg Arg Gly
         305                 310                 315

 gat att aag ctg acg caa ttg gca atg cta ctg gca gag att tcc agt     1188
 Asp Ile Lys Leu Thr Gln Leu Ala Met Leu Leu Ala Glu Ile Ser Ser
     320                 325                 330

 gtt gcc cac cag aaa gat ggc agc ttc tgc cct att gtt atg tgt ggt     1236
 Val Ala His Gln Lys Asp Gly Ser Phe Cys Pro Ile Val Met Cys Gly
 335                 340                 345                 350

 gac ttt aat tct gtt cct ggt tct cca cta tat agt ttc ata aag gaa     1284
 Asp Phe Asn Ser Val Pro Gly Ser Pro Leu Tyr Ser Phe Ile Lys Glu
                 355                 360                 365

 gga aaa ttg aat tat gaa gga ctt ccc ata gga aag gta tct ggc cag     1332
 Gly Lys Leu Asn Tyr Glu Gly Leu Pro Ile Gly Lys Val Ser Gly Gln
             370                 375                 380

 gaa cag tct tca cgg gga caa aga att tta tct att cca att tgg ccc     1380
 Glu Gln Ser Ser Arg Gly Gln Arg Ile Leu Ser Ile Pro Ile Trp Pro
         385                 390                 395

 cca aac cta ggt atc tca cag aac tgt gtg tat gag gta cag cag gta     1428
 Pro Asn Leu Gly Ile Ser Gln Asn Cys Val Tyr Glu Val Gln Gln Val
     400                 405                 410

 cca aaa gta gaa aag aca gac agt gat ctg aca caa aca cag ctg aag     1476
 Pro Lys Val Glu Lys Thr Asp Ser Asp Leu Thr Gln Thr Gln Leu Lys
 415                 420                 425                 430

 caa aca gag gtc cta gtg aca gct gaa aaa ttg tct tca aat tta cag     1524
 Gln Thr Glu Val Leu Val Thr Ala Glu Lys Leu Ser Ser Asn Leu Gln
                 435                 440                 445

 cac cat ttc agt ttg gca tct gtt tat tca cat tac ttt cct gac act     1572
 His His Phe Ser Leu Ala Ser Val Tyr Ser His Tyr Phe Pro Asp Thr
             450                 455                 460

 gga att cca gaa gtg acc acc tgt cat tcc cga agt gcc ata act gtg     1620
 Gly Ile Pro Glu Val Thr Thr Cys His Ser Arg Ser Ala Ile Thr Val
         465                 470                 475

 gat tat att ttc tac tct gca gaa aag gaa gat gtt gct ggg cac cca     1668
 Asp Tyr Ile Phe Tyr Ser Ala Glu Lys Glu Asp Val Ala Gly His Pro
     480                 485                 490

 gga gct gaa gtt gct ttg gtt ggt ggc ttg aaa ctt cta gct aga ctg     1716
 Gly Ala Glu Val Ala Leu Val Gly Gly Leu Lys Leu Leu Ala Arg Leu
 495                 500                 505                 510

 tca ctt ctt aca gaa caa gac tta tgg act gtt aat gga ctt cca aac     1764
 Ser Leu Leu Thr Glu Gln Asp Leu Trp Thr Val Asn Gly Leu Pro Asn
                 515                 520                 525

 gaa aat aac tct tca gat cat ctg cct tta ttg gca aag ttc aga ctt     1812
 Glu Asn Asn Ser Ser Asp His Leu Pro Leu Leu Ala Lys Phe Arg Leu
             530                 535                 540

 gag ctc tga ctctctt tgatcacata ctaattttct ttccaatttg tattgttttt     1868
 Glu Leu 


 caaagaatgt aaagttctta agtgtatgca tgttgtttat ttttgcactg tggagattct   1928

 gaagcggtta tgttagatgc tttgaaactc catatcagaa gaaataactt tataacaatt   1988

 ttttttaata atgaaaaata ttttcctgac aagtgagctc taaattctct ttattgtaaa   2048

 agagatgtaa aggttttata ttctaaatcc tagtaaaatt gacagtgatt tttaaatata   2108

 atgcatcttc ctttgtctgc ttagtaaaaa a                                  2139




      <210> 175
      <211> 1031
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(813)

      <400> 175
 taagcttgcg gccgctctgc gcgttttccg atttcttgct ggttgaatac ctccctctcc     60

 actcccatct tcaggccagc agtatctgtt ggaaatgttg gccagcttgc a atg gat     117
                                                          Met Asp
                                                            1

 ctg att att tct aca ctg aat atg tct aag att ggt tac ttc tat acc      165
 Leu Ile Ile Ser Thr Leu Asn Met Ser Lys Ile Gly Tyr Phe Tyr Thr
           5                  10                  15

 gat tgt ctt gtg cca atg gtt gga aac aat cca tat gcg acc aca gaa      213
 Asp Cys Leu Val Pro Met Val Gly Asn Asn Pro Tyr Ala Thr Thr Glu
      20                  25                  30

 gga aat tca aca gaa ctt agc ata aat gct gaa gtg tat tca ttg cct      261
 Gly Asn Ser Thr Glu Leu Ser Ile Asn Ala Glu Val Tyr Ser Leu Pro
  35                  40                  45                  50

 tca aga aag ctg gtg gct cta cag tta aga tcc att ttt att aag tat      309
 Ser Arg Lys Leu Val Ala Leu Gln Leu Arg Ser Ile Phe Ile Lys Tyr
                  55                  60                  65

 aaa tca aag cca ttc tgt gaa aaa ctg ctt tcc tgg gtg aaa agc agt      357
 Lys Ser Lys Pro Phe Cys Glu Lys Leu Leu Ser Trp Val Lys Ser Ser
              70                  75                  80

 ggc tgt gcc aga gtc att gtt ctt tca agc agt cat tca tat cag cgt      405
 Gly Cys Ala Arg Val Ile Val Leu Ser Ser Ser His Ser Tyr Gln Arg
          85                  90                  95

 aat gat ctg cag ctt cgt agt act ccc ttc cgg tac cta ctt aca cct      453
 Asn Asp Leu Gln Leu Arg Ser Thr Pro Phe Arg Tyr Leu Leu Thr Pro
     100                 105                 110

 tcc atg caa aaa agt gtt caa aat aaa ata aag agc ctt aac tgg gaa      501
 Ser Met Gln Lys Ser Val Gln Asn Lys Ile Lys Ser Leu Asn Trp Glu
 115                 120                 125                 130

 gaa atg gaa aaa agc cgg tgc att cct gaa ata gat gat tcc gag ttt      549
 Glu Met Glu Lys Ser Arg Cys Ile Pro Glu Ile Asp Asp Ser Glu Phe
                 135                 140                 145

 tgt atc cgc att ccg gga gga ggt atc aca aaa aca ctc tat gat gaa      597
 Cys Ile Arg Ile Pro Gly Gly Gly Ile Thr Lys Thr Leu Tyr Asp Glu
             150                 155                 160

 agc tgt tct aaa gaa atc caa atg gca gtt ctg ctg aaa ttt gtt tca      645
 Ser Cys Ser Lys Glu Ile Gln Met Ala Val Leu Leu Lys Phe Val Ser
         165                 170                 175

 gaa ggg gac aac atc cca gat gca tta ggt ctt gtt gag tat ctt aat      693
 Glu Gly Asp Asn Ile Pro Asp Ala Leu Gly Leu Val Glu Tyr Leu Asn
     180                 185                 190

 gag tgg ctt cag ata ctc aaa cca ctt agc gat gac ccc aca gta tct      741
 Glu Trp Leu Gln Ile Leu Lys Pro Leu Ser Asp Asp Pro Thr Val Ser
 195                 200                 205                 210

 gcc tca cgg tgg aaa ata cca agt tct tgg aga tta ctc ttt ggc agt      789
 Ala Ser Arg Trp Lys Ile Pro Ser Ser Trp Arg Leu Leu Phe Gly Ser
                 215                 220                 225

 ggt ctt ccc cct gca ctt ttc tga tctaatttct gttttatacc ttatacccaa     843
 Gly Leu Pro Pro Ala Leu Phe 
             230

 aacacttact accaacacag ctgttaaaca ttctatacaa aaaaattgta tgatctggta    903

 ttaggaaatt actttcacag taaatatcaa agaaaaaaga ttaagggtct ctttgccatg    963

 cttttcatca tatgcaccaa atgtaaattt tgtacaataa aattttattt cctaagtaaa   1023

 aaaaaaaa                                                            1031




      <210> 176
      <211> 2093
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1923)

      <400> 176
 gggcctctta aaaaaaggag gcaggaaata gagagtgatt ctgaaagtga tggtgagctt     60

 caggacagaa agaaagttag agtggaggta gagcagggag agacatcagt gcccccaggt    120

 tcagcactgg ttgggccctc ctgtgtc    atg gat gac ttc agg gac cca cag     171
                                  Met Asp Asp Phe Arg Asp Pro Gln
                                    1               5

 cga tgg aag gaa tgt gcc aag caa ggg aaa atg cca tgt tac ttt gat      219
 Arg Trp Lys Glu Cys Ala Lys Gln Gly Lys Met Pro Cys Tyr Phe Asp
      10                  15                  20

 ctt att gaa gaa aat gtt tat tta aca gaa aga aag aag aat aaa tct      267
 Leu Ile Glu Glu Asn Val Tyr Leu Thr Glu Arg Lys Lys Asn Lys Ser
  25                  30                  35                  40

 cat cga gat att aag cga atg cag tgt gag tgt aca cct ctt tct aaa      315
 His Arg Asp Ile Lys Arg Met Gln Cys Glu Cys Thr Pro Leu Ser Lys
                  45                  50                  55

 gat gaa aga gct caa ggt gaa ata gca tgt ggg gaa gat tgt ctt aat      363
 Asp Glu Arg Ala Gln Gly Glu Ile Ala Cys Gly Glu Asp Cys Leu Asn
              60                  65                  70

 cgt ctt ctc atg att gaa tgt tct tct cgg tgt cca aat ggg gat tat      411
 Arg Leu Leu Met Ile Glu Cys Ser Ser Arg Cys Pro Asn Gly Asp Tyr
          75                  80                  85

 tgt tcc aat aga cgg ttt cag aga aaa cag cat gca gat gtg gaa gtc      459
 Cys Ser Asn Arg Arg Phe Gln Arg Lys Gln His Ala Asp Val Glu Val
      90                  95                 100

 ata ctc aca gaa aag aaa ggc tgg ggc ttg aga gct gcc aaa gac ctt      507
 Ile Leu Thr Glu Lys Lys Gly Trp Gly Leu Arg Ala Ala Lys Asp Leu
 105                 110                 115                 120

 cct tcg aac acc ttt gtc cta gaa tat tgt gga gag gta ctc gat cat      555
 Pro Ser Asn Thr Phe Val Leu Glu Tyr Cys Gly Glu Val Leu Asp His
                 125                 130                 135

 aaa gag ttt aaa gct cga gtg aag gag tat gca cga aac aaa aac atc      603
 Lys Glu Phe Lys Ala Arg Val Lys Glu Tyr Ala Arg Asn Lys Asn Ile
             140                 145                 150

 cat tac tat ttc atg gcc ctg aag aat gat gag ata ata gat gcc act      651
 His Tyr Tyr Phe Met Ala Leu Lys Asn Asp Glu Ile Ile Asp Ala Thr
         155                 160                 165

 caa aaa gga aat tgc tct cgt ttc atg aat cac agc tgt gaa cca aat      699
 Gln Lys Gly Asn Cys Ser Arg Phe Met Asn His Ser Cys Glu Pro Asn
     170                 175                 180

 tgt gaa acc caa aaa tgg act gtg aac gga caa ctg agg gtt ggg ttt      747
 Cys Glu Thr Gln Lys Trp Thr Val Asn Gly Gln Leu Arg Val Gly Phe
 185                 190                 195                 200

 ttt acc acc aaa ctg gtt cct tca ggc tca gag tta acg ttt gac tat      795
 Phe Thr Thr Lys Leu Val Pro Ser Gly Ser Glu Leu Thr Phe Asp Tyr
                 205                 210                 215

 cag ttc cag aga tat gga aaa gaa gcc cag aaa tgt ttc tgc gga tca      843
 Gln Phe Gln Arg Tyr Gly Lys Glu Ala Gln Lys Cys Phe Cys Gly Ser
             220                 225                 230

 gcc aat tgc cgg ggt tac ctg gga gga gaa aac aga gtc agc atc aga      891
 Ala Asn Cys Arg Gly Tyr Leu Gly Gly Glu Asn Arg Val Ser Ile Arg
         235                 240                 245

 gca gca gga ggg aaa atg aag aag gaa cga tct cgt aag aag gat tca      939
 Ala Ala Gly Gly Lys Met Lys Lys Glu Arg Ser Arg Lys Lys Asp Ser
     250                 255                 260

 gtg gat gga gag cta gaa gct ctg atg gaa aat ggt gag ggt ctc tct      987
 Val Asp Gly Glu Leu Glu Ala Leu Met Glu Asn Gly Glu Gly Leu Ser
 265                 270                 275                 280

 gat aaa aac cag gtg ctc agc tta tcc cgg cta atg gtt aga att gaa     1035
 Asp Lys Asn Gln Val Leu Ser Leu Ser Arg Leu Met Val Arg Ile Glu
                 285                 290                 295

 act ttg gag cag aaa ctt acc tgt ctg gaa ctc ata cag aac aca cac     1083
 Thr Leu Glu Gln Lys Leu Thr Cys Leu Glu Leu Ile Gln Asn Thr His
             300                 305                 310

 tca cag tcc tgc ctg aag tcc ttt ctg gaa cgt cat ggg ctg tct ttg     1131
 Ser Gln Ser Cys Leu Lys Ser Phe Leu Glu Arg His Gly Leu Ser Leu
         315                 320                 325

 ttg tgg atc tgg atg gca gag cta ggt gac ggc cgg gaa agt aac cag     1179
 Leu Trp Ile Trp Met Ala Glu Leu Gly Asp Gly Arg Glu Ser Asn Gln
     330                 335                 340

 aag ctt cag gaa gag att ata aag act ttg gaa cac ttg ccc att cct     1227
 Lys Leu Gln Glu Glu Ile Ile Lys Thr Leu Glu His Leu Pro Ile Pro
 345                 350                 355                 360

 act aaa aat atg ttg gag gaa agc aaa gta ctt cca att att caa cgc     1275
 Thr Lys Asn Met Leu Glu Glu Ser Lys Val Leu Pro Ile Ile Gln Arg
                 365                 370                 375

 tgg tct cag act aag act gct gtc cct ccg ttg agt gaa gga gat ggg     1323
 Trp Ser Gln Thr Lys Thr Ala Val Pro Pro Leu Ser Glu Gly Asp Gly
             380                 385                 390

 tat tct agt gag aat aca tcg cgt gct cat aca cca ctc aac aca cct     1371
 Tyr Ser Ser Glu Asn Thr Ser Arg Ala His Thr Pro Leu Asn Thr Pro
         395                 400                 405

 gat cct tcc acc aag ctg agc aca gaa gct gac aca gac act ccc aag     1419
 Asp Pro Ser Thr Lys Leu Ser Thr Glu Ala Asp Thr Asp Thr Pro Lys
     410                 415                 420

 aaa cta atg ttt cgc aga ctg aaa att ata agt gaa aat agc atg gac     1467
 Lys Leu Met Phe Arg Arg Leu Lys Ile Ile Ser Glu Asn Ser Met Asp
 425                 430                 435                 440

 agt gca atc tct gat gca acc agt gag cta gaa ggc aaa gga tgg caa     1515
 Ser Ala Ile Ser Asp Ala Thr Ser Glu Leu Glu Gly Lys Gly Trp Gln
                 445                 450                 455

 gag gat ctt gat caa tta gaa aat gtc cct gta gag gaa gag gaa gaa     1563
 Glu Asp Leu Asp Gln Leu Glu Asn Val Pro Val Glu Glu Glu Glu Glu
             460                 465                 470

 ttg cag tca caa cag cta ctc cca caa cag ctg cct gaa tgc aaa gtt     1611
 Leu Gln Ser Gln Gln Leu Leu Pro Gln Gln Leu Pro Glu Cys Lys Val
         475                 480                 485

 gat agt gaa acc aac ata gaa gct agt aag cta cct aca tct gaa cca     1659
 Asp Ser Glu Thr Asn Ile Glu Ala Ser Lys Leu Pro Thr Ser Glu Pro
     490                 495                 500

 gaa gct gac gct gaa ata gag ccc aaa gag agc aac ggc aca aaa cta     1707
 Glu Ala Asp Ala Glu Ile Glu Pro Lys Glu Ser Asn Gly Thr Lys Leu
 505                 510                 515                 520

 gaa gaa cct att aat gaa gaa aca cca tcc caa gat gaa gag gag ggt     1755
 Glu Glu Pro Ile Asn Glu Glu Thr Pro Ser Gln Asp Glu Glu Glu Gly
                 525                 530                 535

 gtg tct gat gtg gag agt gaa agg agc caa gaa cag cca gat aaa aca     1803
 Val Ser Asp Val Glu Ser Glu Arg Ser Gln Glu Gln Pro Asp Lys Thr
             540                 545                 550

 gtg gat ata agt gat ttg gcc acc aaa ctc ctg gac agt tgg aaa gac     1851
 Val Asp Ile Ser Asp Leu Ala Thr Lys Leu Leu Asp Ser Trp Lys Asp
         555                 560                 565

 cta aag gag gta tat cga att cca aag aaa agt caa act gaa aag gaa     1899
 Leu Lys Glu Val Tyr Arg Ile Pro Lys Lys Ser Gln Thr Glu Lys Glu
     570                 575                 580

 aac aca aga aat cag cct gaa taa atggaatgac ttgtctgcct cacatatttt    1953
 Asn Thr Arg Asn Gln Pro Glu 
 585                 590

 aaggtgcaga gtcagaatat gaactgttgc aactgaacga ggaagggatg ctgttggctt   2013

 cagagatcaa acacctgccc cgaagactcc taataggtca agagagagag acccagacaa   2073

 gcaaactcaa aaaaaaaaaa                                               2093




      <210> 177
      <211> 1378
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(920)

      <400> 177
 caaaa    atg gcg gag gct tcg gcg gcc ggg gcg gac tcg ggc gcc gct      47
          Met Ala Glu Ala Ser Ala Ala Gly Ala Asp Ser Gly Ala Ala
            1               5                  10

 gta gcc gcc cac cgg ttt ttc tgc cac ttt tgc aag ggc gag gtc agc       95
 Val Ala Ala His Arg Phe Phe Cys His Phe Cys Lys Gly Glu Val Ser
  15                  20                  25                  30

 ccc aaa cta ccg gaa tat ata tgt ccc aga tgt gaa tca ggc ttt att      143
 Pro Lys Leu Pro Glu Tyr Ile Cys Pro Arg Cys Glu Ser Gly Phe Ile
                  35                  40                  45

 gaa gaa gtg aca gat gat tcc agt ttt tta ggt ggt ggc ggc agt cgg      191
 Glu Glu Val Thr Asp Asp Ser Ser Phe Leu Gly Gly Gly Gly Ser Arg
              50                  55                  60

 ata gac aat acc aca aca aca cat ttt gca gag ctt tgg ggc cat ttg      239
 Ile Asp Asn Thr Thr Thr Thr His Phe Ala Glu Leu Trp Gly His Leu
          65                  70                  75

 gat cac acg atg ttt ttt caa gat ttt aga ccc ttt cta agt agc agt      287
 Asp His Thr Met Phe Phe Gln Asp Phe Arg Pro Phe Leu Ser Ser Ser
      80                  85                  90

 cca ctg gac caa gat aat aga gcc aat gaa agg ggt cac cag act cac      335
 Pro Leu Asp Gln Asp Asn Arg Ala Asn Glu Arg Gly His Gln Thr His
  95                 100                 105                 110

 act gac ttc tgg gga gca aga cct cca cgg ttg cca ttg ggt cgg aga      383
 Thr Asp Phe Trp Gly Ala Arg Pro Pro Arg Leu Pro Leu Gly Arg Arg
                 115                 120                 125

 tac aga tct cga gga agt tct cgt cct gac aga tct cca gct att gaa      431
 Tyr Arg Ser Arg Gly Ser Ser Arg Pro Asp Arg Ser Pro Ala Ile Glu
             130                 135                 140

 gga ata cta caa cac atc ttt gca gga ttc ttt gca aat tct gcc att      479
 Gly Ile Leu Gln His Ile Phe Ala Gly Phe Phe Ala Asn Ser Ala Ile
         145                 150                 155

 cct gga tct cca cac cct ttt tcc tgg agc ggg atg ctg cac tcc aac      527
 Pro Gly Ser Pro His Pro Phe Ser Trp Ser Gly Met Leu His Ser Asn
     160                 165                 170

 cct ggg gac tat gcc tgg ggt cag aca ggg ctt gat gcc att gta acc      575
 Pro Gly Asp Tyr Ala Trp Gly Gln Thr Gly Leu Asp Ala Ile Val Thr
 175                 180                 185                 190

 cag ctt tta gga caa ctg gaa aac aca ggc cct ccc cca gct gac aag      623
 Gln Leu Leu Gly Gln Leu Glu Asn Thr Gly Pro Pro Pro Ala Asp Lys
                 195                 200                 205

 gaa aag atc aca tct ctt cca aca gtg aca gta act cag gaa caa gtt      671
 Glu Lys Ile Thr Ser Leu Pro Thr Val Thr Val Thr Gln Glu Gln Val
             210                 215                 220

 gat atg ggt tta gag tgt cca gta tgc aaa gaa gat tac aca gtt gaa      719
 Asp Met Gly Leu Glu Cys Pro Val Cys Lys Glu Asp Tyr Thr Val Glu
         225                 230                 235

 gag gaa gtc cgg cag tta cct tgc aat cac ttc ttt cac agc agt tgt      767
 Glu Glu Val Arg Gln Leu Pro Cys Asn His Phe Phe His Ser Ser Cys
     240                 245                 250

 att gtg ccg tgg cta gaa ctg cat gac aca tgt cct gta tgt agg aag      815
 Ile Val Pro Trp Leu Glu Leu His Asp Thr Cys Pro Val Cys Arg Lys
 255                 260                 265                 270

 agc tta aat ggt gag gac tct act cgg caa agc cag agc act gag gcc      863
 Ser Leu Asn Gly Glu Asp Ser Thr Arg Gln Ser Gln Ser Thr Glu Ala
                 275                 280                 285

 tct gca agc aac aga ttt agc aat gac agt cag cta cat gac cga tgg      911
 Ser Ala Ser Asn Arg Phe Ser Asn Asp Ser Gln Leu His Asp Arg Trp
             290                 295                 300

 act ttc tga agctaaa gaccacacct gaatcagggc tgtggtaatc atcttaccat      967
 Thr Phe 


 agctgtaaat tgtatcaaaa caaaaaatta gtagatggat ttaggaatat gtaagaaact   1027

 caacacataa tataaatgca atgaatgttt ttcttcttta aatttaaagt tagtatctac   1087

 agatggaatt gtatctacaa ccaaatgcct cttatccctg aattcagagt gataatttta   1147

 taagtgtgaa acttaattat gtagggctcc ccccgtctga atagaattaa ttccttaaag   1207

 tctagttagg gtcctgctgt ctgtcatgtt gccttgtaac ggatgtttcc acctccttct   1267

 ccaacctcta ccccaccatt agtgtatttt actataaaaa cagtggaacc acagccctaa   1327

 agtcctgctg atataaagtc cttttgtctt aattgtattt aaaaaaaaaa a            1378




      <210> 178
      <211> 693
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(459)

      <400> 178
 ttc  atg gaa tct ggt gtt tat tac act cgg ggg aga gag gag gtc act      48
      Met Glu Ser Gly Val Tyr Tyr Thr Arg Gly Arg Glu Glu Val Thr
        1               5                  10                  15

 cgg tcc agc ggt ggc cgc agt gtg ggg ctg tca cac gta gta aag gcg       96
 Arg Ser Ser Gly Gly Arg Ser Val Gly Leu Ser His Val Val Lys Ala
                  20                  25                  30

 cat ggc gtc tcg gcc cgc gca ctg tgt gac tgg aag aac aca gcc tcc      144
 His Gly Val Ser Ala Arg Ala Leu Cys Asp Trp Lys Asn Thr Ala Ser
              35                  40                  45

 tgg tcc tcg cct cct ccg ctg tct ccc tgg agt tct tgc aag tcg gcc      192
 Trp Ser Ser Pro Pro Pro Leu Ser Pro Trp Ser Ser Cys Lys Ser Ala
          50                  55                  60

 agg atg tct cag gct gag ttt gag aaa gct gca gag gag gtt agg cac      240
 Arg Met Ser Gln Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His
      65                  70                  75

 ctt aag acc aag cca tcg gat gag gag atg ctg ttc atc tat ggc cac      288
 Leu Lys Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His
  80                  85                  90                  95

 tac aaa caa gca act gtg ggc gac ata aat aca gaa cgg ccc ggg atg      336
 Tyr Lys Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met
                 100                 105                 110

 ttg gac ttc acg ggc aag gcc aag tgg gat gcc tgg aat gag ctg aaa      384
 Leu Asp Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys
             115                 120                 125

 ggg act tcc aag gaa gat gcc atg aaa gct tac atc aac aaa gta gaa      432
 Gly Thr Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu
         130                 135                 140

 gag cta aag aaa aaa tac ggg ata tga gagac tggatttggt tactgtgcca      484
 Glu Leu Lys Lys Lys Tyr Gly Ile 
     145                 150

 tgtgtttatc ctaaactgag acaatgcctt gtttttttct aataccgtgg atggtgggaa    544

 ttcgggaaaa taaccagtta aaccagctac tcaaggctgc tcaccatacg gctctaacag    604

 attaggggct aaaacgatta ctgactttcc ttgagtagtt tttatctgaa atcaattaaa    664

 agtgtatttg ttactttaaa aaaaaaaaa                                      693




      <210> 179
      <211> 2655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(1455)

      <400> 179
 aaagcatgca aaggaagact ttattcagga tcatcgtgat aggtattgga agcacagcag     60

 tgagattttg caatgggtac aagagattgg gttcaactcc aaattcagca tgaacgagta    120

 ggaatttata gtcaaggagc aggttaggga tcactggatg acaaaatact aagaggaaat    180

 gtctgggata agtaggattc tggctaaacg cacctgttgg gattctttct gaagagagag    240

 acctggatga taagacatca tcgcctgggg gatagtggag gatggtgaac cctgattctg    300

 aagtcggtgt ctgctgcgtt cacggcagga ttcggttagg aggaacagca cagc  atg     357
                                                              Met
                                                                1

 ctg ggc tct gga ttt aaa gct gag cgc tta aga gtg aat ttg aga tta      405
 Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg Leu
               5                  10                  15

 gtc ata aat cgc ctt aaa cta ttg gag aaa aag aaa acg gaa ctg gcc      453
 Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu Ala
          20                  25                  30

 cag aaa gca agg aag gag att gct gac tat ctg gct gct ggg aaa gat      501
 Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys Asp
      35                  40                  45

 gaa cga gct cgg atc cgt gtg gag cac att atc cgg gaa gac tac ctc      549
 Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr Leu
  50                  55                  60                  65

 gtg gag gcc atg gag atc ctg gag ctg tac tgt gac ctg ctg ctg gct      597
 Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu Ala
                  70                  75                  80

 cgg ttt ggc ctt atc cag tct atg aag gaa cta gat tct ggt ctg gct      645
 Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu Ala
              85                  90                  95

 gaa tct gtg tct aca ttg atc tgg gct gct cct cga ctc cag tca gaa      693
 Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser Glu
         100                 105                 110

 gtg gct gag ttg aaa ata gtt gct gat cag ctc tgt gcc aag tat agc      741
 Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr Ser
     115                 120                 125

 aag gaa tat ggc aag cta tgt agg acc aac cag att gga act gtg aat      789
 Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val Asn
 130                 135                 140                 145

 gac agg cta atg cac aag ctg agt gtg gaa gcc cca ccc aaa atc ctg      837
 Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile Leu
                 150                 155                 160

 gtg gag aga tac ctg att gaa att gca aag aat tac aac gta ccc tat      885
 Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro Tyr
             165                 170                 175

 gaa cct gac tct gtg gtc atg gca gaa gct cct cct ggg gta gag aca      933
 Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu Thr
         180                 185                 190

 gat ctt att gat gtt gga ttc aca gat gat gtg aag aaa gga ggc cct      981
 Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly Pro
     195                 200                 205

 gga aga gga ggg agt ggt ggc ttc aca gca cca gtt ggt gga cct gat     1029
 Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro Asp
 210                 215                 220                 225

 gga acg gtg cca atg ccc atg ccc atg ccc atg cct atg cca tct gca     1077
 Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser Ala
                 230                 235                 240

 aat acg cct ttc tca tat cca ctg cca aag gga cca tca gat ttc aat     1125
 Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe Asn
             245                 250                 255

 gga ctg cca atg ggg act tat cag gcc ttt ccc aat att cat cca cct     1173
 Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro Pro
         260                 265                 270

 cag ata cca gca act ccc cca tcg tat gaa tct gta gat gac att aat     1221
 Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Val Asp Asp Ile Asn
     275                 280                 285

 gct gat aag aat atc tct tct gca cag att gtt ggt cct gga ccc aag     1269
 Ala Asp Lys Asn Ile Ser Ser Ala Gln Ile Val Gly Pro Gly Pro Lys
 290                 295                 300                 305

 cca gaa gcc tct gca aag ctt cct tcc aga cct gca gat aac tat gac     1317
 Pro Glu Ala Ser Ala Lys Leu Pro Ser Arg Pro Ala Asp Asn Tyr Asp
                 310                 315                 320

 aac ttt gtc cta cca gag ttg cca tct gtg cca gac aca cta cca act     1365
 Asn Phe Val Leu Pro Glu Leu Pro Ser Val Pro Asp Thr Leu Pro Thr
             325                 330                 335

 gca tct gct ggt gcc agc acc tca gca tct gaa gac att gac ttt gat     1413
 Ala Ser Ala Gly Ala Ser Thr Ser Ala Ser Glu Asp Ile Asp Phe Asp
         340                 345                 350

 gat ctt tcc cgg agg ttt gaa gag ctg aaa aag aaa aca tag gtctctt     1462
 Asp Leu Ser Arg Arg Phe Glu Glu Leu Lys Lys Lys Thr 
     355                 360                 365

 aaaccaggca actttcacgt tttgggagtt gagactgagc aatttctcct tgtaacaaag   1522

 aatctccatg aaattctgtt tcatctgtta accgtcactc agcacaacac tccctctggg   1582

 ctctcttcct gctcctccag attctgctgc tttccagttc tctgttgatc ctgagactaa   1642

 caattggaga ctgaggccag agcaactggc tcctggcagc tgtgcttgtc cgtttcctgt   1702

 cagagtgatc ccaggtttcc tcctggcccg tcccatggtc cctccacagg agtgtgagag   1762

 gatgggggaa gcactgtggg aagaccacca aagatggctg gacagtggga gagagcacgt   1822

 tgtgaagcat cccagcctcg tgttgaggtt ccagacttag aaacagaccc ctctgtacag   1882

 ggggattgtg gtgagtgaga atcaaggcca ccttgtgtgt tttctcactc tcgaatgcaa   1942

 gtgggagagg gaaaatgact cgggacgcca ttgtaacggt tcctggaagc tgggccctct   2002

 cattggcata tacagtactc ctcgctgcag ggcactgtcc caccgggatc cagttgcaaa   2062

 gtttgtcttg acagttgaag gcctcgctta gttgtactgg attctcaggg agccctctgt   2122

 ggccttttgc tttgcgtgct gtttcccttg taccagaggg cggcaccgtg gaaattctgt   2182

 tttccctgta gcatattgtg ttggattgca ttactggcag agaaaggaca aggtgccatt   2242

 caagtcctag ggtgggcttc cagctgcctt aatagaagta ctcaagtctt ttgggtagtg   2302

 agctggaaag cctacaggaa aagaggggta cctgttttca tttgaaaact ttgattcatg   2362

 gaacctttaa aactaatctc agaaaaattt ttggtgccca tgcagctgta gttgttcact   2422

 gctttcctgg atggatggga ctcttatgtc ataacttctg ttactccttt ggcccatagc   2482

 taaggtcatc cttccccaca ggggtggctt tgggattgga tgatacagct tttgcttctg   2542

 tgtagtatac ctgtacatac ttgtttcagg cagcctttct ttaatgtttt cagttggttt   2602

 gtattctgta gctcagtagc tgctaataaa gttaaagatc ctgaaaaaaa aaa          2655




      <210> 180
      <211> 1613
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(1563)

      <400> 180
 ggaccaagat ggcggcgccc tgtgagggac aagcgtttgc cgtaggggtt gaaaagaatt     60

 ggggtgcagt agttcgctcc ccagaaggga ccccccagaa aatccggcag ctgatag       117                                                                 
 atg agg gga ttg ccc cgg aag agg gag gcg tgg acg caa cca cac ccg      165
 Met Arg Gly Leu Pro Arg Lys Arg Glu Ala Trp Thr Gln Pro His Pro
   1               5                  10                  15

 ctt gag gct ctc tat gaa tct ctg aga gtc tta gag aag gac acg tct      213
 Leu Glu Ala Leu Tyr Glu Ser Leu Arg Val Leu Glu Lys Asp Thr Ser
              20                  25                  30

 gcc aca tcc cag tca gtt aat gga tca ccc caa gcg gaa caa cct tca      261
 Ala Thr Ser Gln Ser Val Asn Gly Ser Pro Gln Ala Glu Gln Pro Ser
          35                  40                  45

 ttg gaa tct aca agc aaa gaa gcc ttc ttt agc aga gtg gaa aca ttt      309
 Leu Glu Ser Thr Ser Lys Glu Ala Phe Phe Ser Arg Val Glu Thr Phe
      50                  55                  60

 tct tct ttg aaa tgg gca ggt aag ccc ttt gag ctg tct cca ctc gtc      357
 Ser Ser Leu Lys Trp Ala Gly Lys Pro Phe Glu Leu Ser Pro Leu Val
  65                  70                  75                  80

 tgt gca aaa tat ggc tgg gtc aca gtg gaa tgt gat atg ctc aag tgc      405
 Cys Ala Lys Tyr Gly Trp Val Thr Val Glu Cys Asp Met Leu Lys Cys
                  85                  90                  95

 tct agc tgt caa gct ttt ctc tgt gcc agt tta caa cca gct ttt gac      453
 Ser Ser Cys Gln Ala Phe Leu Cys Ala Ser Leu Gln Pro Ala Phe Asp
             100                 105                 110

 ttt gac aga tat aag caa cga tgt gct gag ctg aag aaa gcc ttg tgt      501
 Phe Asp Arg Tyr Lys Gln Arg Cys Ala Glu Leu Lys Lys Ala Leu Cys
         115                 120                 125

 act gcc cat gag aag ttc tgt ttc tgg cca gac agc cca tcc cca gac      549
 Thr Ala His Glu Lys Phe Cys Phe Trp Pro Asp Ser Pro Ser Pro Asp
     130                 135                 140

 cga ttt ggg atg ttg ccc ctg gat gag cct gct att ctt gtt agt gaa      597
 Arg Phe Gly Met Leu Pro Leu Asp Glu Pro Ala Ile Leu Val Ser Glu
 145                 150                 155                 160

 ttc cta gat cgt ttt caa agc ctt tgt cac ttg gac ctc cag ctt cct      645
 Phe Leu Asp Arg Phe Gln Ser Leu Cys His Leu Asp Leu Gln Leu Pro
                 165                 170                 175

 tcc cta agg ccg gag gac ttg aaa act atg tgc ttg aca gaa gac aag      693
 Ser Leu Arg Pro Glu Asp Leu Lys Thr Met Cys Leu Thr Glu Asp Lys
             180                 185                 190

 atc agt ctt ctc cta cac ttg ctt gaa gat gaa ctt gat cac cga act      741
 Ile Ser Leu Leu Leu His Leu Leu Glu Asp Glu Leu Asp His Arg Thr
         195                 200                 205

 gat gag aga aaa act aca atc aaa tta ggc tca gac atc caa gtc cac      789
 Asp Glu Arg Lys Thr Thr Ile Lys Leu Gly Ser Asp Ile Gln Val His
     210                 215                 220

 gtc act gcc tgt att ctc tct gtg tgt ggc tgg gcg tgt agt tcc tct      837
 Val Thr Ala Cys Ile Leu Ser Val Cys Gly Trp Ala Cys Ser Ser Ser
 225                 230                 235                 240

 ttg gaa tcc atg cag ctc tcc ctg ata gca tgt tcg caa tgt atg agg      885
 Leu Glu Ser Met Gln Leu Ser Leu Ile Ala Cys Ser Gln Cys Met Arg
                 245                 250                 255

 aag gtg ggg ctc tgg ggc ttc cag cag att gaa tcg tcc atg act gac      933
 Lys Val Gly Leu Trp Gly Phe Gln Gln Ile Glu Ser Ser Met Thr Asp
             260                 265                 270

 ctg gat gca tcc ttt ggc ctg acc agc tcc cca atc cca ggc ctt gag      981
 Leu Asp Ala Ser Phe Gly Leu Thr Ser Ser Pro Ile Pro Gly Leu Glu
         275                 280                 285

 ggg cga cca gag cgc tta cct ctg gtg cct gaa tct cct cgg agg atg     1029
 Gly Arg Pro Glu Arg Leu Pro Leu Val Pro Glu Ser Pro Arg Arg Met
     290                 295                 300

 atg acc cgg agc cag gat gcc act ttc tcc cca ggc tca gag cag gct     1077
 Met Thr Arg Ser Gln Asp Ala Thr Phe Ser Pro Gly Ser Glu Gln Ala
 305                 310                 315                 320

 gaa aag agc cct ggt ccc att gtc tct cga act cgg agc tgg gac tct     1125
 Glu Lys Ser Pro Gly Pro Ile Val Ser Arg Thr Arg Ser Trp Asp Ser
                 325                 330                 335

 tcc agt cct gtt gac cgt cct gag cca gag gct gct agc ccc acc acc     1173
 Ser Ser Pro Val Asp Arg Pro Glu Pro Glu Ala Ala Ser Pro Thr Thr
             340                 345                 350

 aga act cgc cca gtg acc cga agc atg gga aca gga gac acc cct ggc     1221
 Arg Thr Arg Pro Val Thr Arg Ser Met Gly Thr Gly Asp Thr Pro Gly
         355                 360                 365

 ctg gag gta cca tct agc cct ctg cgg aaa gcc aag cga gct cgc ctc     1269
 Leu Glu Val Pro Ser Ser Pro Leu Arg Lys Ala Lys Arg Ala Arg Leu
     370                 375                 380

 tgc tcc tcc agc agt tcg gac aca tct tcc cga agc ttc ttt gat ccc     1317
 Cys Ser Ser Ser Ser Ser Asp Thr Ser Ser Arg Ser Phe Phe Asp Pro
 385                 390                 395                 400

 acc tct cag cat aga gac tgg tgc cct tgg gtg aat atc aca ctt ggc     1365
 Thr Ser Gln His Arg Asp Trp Cys Pro Trp Val Asn Ile Thr Leu Gly
                 405                 410                 415

 aaa gaa agc agg gag aat ggt gga act gaa cca gat gcc agc gcc cca     1413
 Lys Glu Ser Arg Glu Asn Gly Gly Thr Glu Pro Asp Ala Ser Ala Pro
             420                 425                 430

 gca gag cca ggc tgg aaa gca gtg ctg acc atc ctc ttg gcg cac aaa     1461
 Ala Glu Pro Gly Trp Lys Ala Val Leu Thr Ile Leu Leu Ala His Lys
         435                 440                 445

 cag tct agc cag cca gct gaa acg gac tcc atg agt ctc tct gag aaa     1509
 Gln Ser Ser Gln Pro Ala Glu Thr Asp Ser Met Ser Leu Ser Glu Lys
     450                 455                 460

 tca agg aaa gta ttc cga ata ttt cgg cag tgg gaa tct ctg tgc tca     1557
 Ser Arg Lys Val Phe Arg Ile Phe Arg Gln Trp Glu Ser Leu Cys Ser
 465                 470                 475                 480

 tgc tga agatactcca gcgccttcct ggagatagct ggaatgagag tgactttttg      1613
 Cys 






      <210> 181
      <211> 3996
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(3949)

      <400> 181
 gttgaaaggt cccaaattca ag atg cct gag atg agc atc aaa gcc ccc aag      52
                          Met Pro Glu Met Ser Ile Lys Ala Pro Lys
                            1               5                  10

 atc tcc atg cct gat att gac tta aac ctg aaa gga ccc aaa gtg aag      100
 Ile Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys
                  15                  20                  25

 ggc gat gtg gat gtt acc ctt cct aaa gtg gaa ggt gac ctc aag ggc      148
 Gly Asp Val Asp Val Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly
              30                  35                  40

 cca gaa gct gac atc aag ggc cca aaa gtg gac atc aac acc cct gat      196
 Pro Glu Ala Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp
          45                  50                  55

 gtg gat gtt cat ggc cca gac tgg cac ctg aag atg ccc aag gtg aaa      244
 Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys
      60                  65                  70

 atg ccc aaa ttc agc atg cct ggc ttc aaa gga gaa ggt cca gat gtg      292
 Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val
  75                  80                  85                  90

 gat gtg aac ctg ccc aag gct gac att gat gtc tca gga ccc aaa gtg      340
 Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val
                  95                 100                 105

 gac gtt gat gtt cct gat gtg aat atc gaa ggt cca gat gcg aaa cta      388
 Asp Val Asp Val Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu
             110                 115                 120

 aag ggc ccc aag ttc aag atg cct gag atg agc atc aaa gcc ccc aag      436
 Lys Gly Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys Ala Pro Lys
         125                 130                 135

 atc tcc atg cct gat att gac tta aac ctg aaa gga ccc aaa gtg aag      484
 Ile Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys
     140                 145                 150

 ggc gat gtg gat gtt acc ctt cct aaa gtg gaa ggt gac ctc aag ggc      532
 Gly Asp Val Asp Val Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly
 155                 160                 165                 170

 cca gaa gct gac atc aag ggc cca aaa gtg gac atc aac acc cct gat      580
 Pro Glu Ala Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp
                 175                 180                 185

 gtg gat gtt cat ggc cca gac tgg cac ctg aag atg ccc aag gtg aaa      628
 Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys
             190                 195                 200

 atg ccc aaa ttc agc atg cct ggc ttc aaa gga gaa ggt cca gat gtg      676
 Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val
         205                 210                 215

 gat gtg agc ctg ccc aag gcc gac atc gat gtc tcg gga ccc aag gtg      724
 Asp Val Ser Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val
     220                 225                 230

 gac gtt gat att cca gat gtg aat atc gaa ggt cca gac gca aaa ctg      772
 Asp Val Asp Ile Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu
 235                 240                 245                 250

 aag ggc ccc aag ttc aag atg cct gaa ata aat atc aaa gct ccc aag      820
 Lys Gly Pro Lys Phe Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys
                 255                 260                 265

 atc tcc ata cct gat gtt gac ctg gat ttg aaa gga ccc aaa gta aaa      868
 Ile Ser Ile Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Val Lys
             270                 275                 280

 gga gat ttt gat gtg tct gtc cct aag gtt gaa ggg act ttg aaa ggc      916
 Gly Asp Phe Asp Val Ser Val Pro Lys Val Glu Gly Thr Leu Lys Gly
         285                 290                 295

 cca gaa gta gat ctt aaa ggt cca cgt ctg gat ttc gaa ggc cct gat      964
 Pro Glu Val Asp Leu Lys Gly Pro Arg Leu Asp Phe Glu Gly Pro Asp
     300                 305                 310

 gcc aaa ctc agt ggc cca tct ttg aag atg cca tcg ctg gag ata tct     1012
 Ala Lys Leu Ser Gly Pro Ser Leu Lys Met Pro Ser Leu Glu Ile Ser
 315                 320                 325                 330

 gct cct aaa gta act gct cct gat gtt gat ttg cat ctc aag gca cca     1060
 Ala Pro Lys Val Thr Ala Pro Asp Val Asp Leu His Leu Lys Ala Pro
                 335                 340                 345

 aaa att gga ttt tca ggt ccg aag tta gaa ggt ggt gaa gtg gac ctc     1108
 Lys Ile Gly Phe Ser Gly Pro Lys Leu Glu Gly Gly Glu Val Asp Leu
             350                 355                 360

 aag gga ccc aaa gtt gaa gct cca agc tta gat gta cac atg gac agc     1156
 Lys Gly Pro Lys Val Glu Ala Pro Ser Leu Asp Val His Met Asp Ser
         365                 370                 375

 cca gat att aac atc gaa ggg cca gat gtt aaa atc ccc aaa ttt aag     1204
 Pro Asp Ile Asn Ile Glu Gly Pro Asp Val Lys Ile Pro Lys Phe Lys
     380                 385                 390

 aaa ccc aag ttt gga ttt ggg cca aaa agc ccc aaa gct gac atc aag     1252
 Lys Pro Lys Phe Gly Phe Gly Pro Lys Ser Pro Lys Ala Asp Ile Lys
 395                 400                 405                 410

 tca cct tca ctg gat gtc act gtt cct gag gca gag ctg aac ctt gag     1300
 Ser Pro Ser Leu Asp Val Thr Val Pro Glu Ala Glu Leu Asn Leu Glu
                 415                 420                 425

 act cct gaa att agt gtt ggt ggc aag ggc aag aaa agt aag ttt aaa     1348
 Thr Pro Glu Ile Ser Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys
             430                 435                 440

 atg cct aaa att cat atg agt ggt cct aag att aag gcc aaa aaa cag     1396
 Met Pro Lys Ile His Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln
         445                 450                 455

 gga ttt gac ctg aat gtt cct ggg ggt gaa att gat gcc agc ctc aag     1444
 Gly Phe Asp Leu Asn Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys
     460                 465                 470

 gct ccg gat gta gat gtc aac atc gca ggg ccg gat gct gca ctc aaa     1492
 Ala Pro Asp Val Asp Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys
 475                 480                 485                 490

 gtc gac gtg aaa tcg ccc aaa acc aag aaa acg atg ttt gga aaa atg     1540
 Val Asp Val Lys Ser Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met
                 495                 500                 505

 tac ttc cca gat gta gag ttt gac att aaa tca cct aaa ttt aaa gct     1588
 Tyr Phe Pro Asp Val Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys Ala
             510                 515                 520

 gag gcc cct ctc cct agc ccc aaa ctg gag ggt gaa ctc cag gca cct     1636
 Glu Ala Pro Leu Pro Ser Pro Lys Leu Glu Gly Glu Leu Gln Ala Pro
         525                 530                 535

 gat ctg gaa ctt tct ttg cca gcg att cac gtc gaa ggt ctt gac atc     1684
 Asp Leu Glu Leu Ser Leu Pro Ala Ile His Val Glu Gly Leu Asp Ile
     540                 545                 550

 aag gcg aag gct ccc aag gtc aag atg cca gat gtg gac atc tca gtg     1732
 Lys Ala Lys Ala Pro Lys Val Lys Met Pro Asp Val Asp Ile Ser Val
 555                 560                 565                 570

 cca aaa ata gag ggt gac ctg aaa ggc ccc aaa gtg cag gca aac ttg     1780
 Pro Lys Ile Glu Gly Asp Leu Lys Gly Pro Lys Val Gln Ala Asn Leu
                 575                 580                 585

 ggt gca cct gac atc aac atc gaa ggc cta gat gct aaa gtc aaa aca     1828
 Gly Ala Pro Asp Ile Asn Ile Glu Gly Leu Asp Ala Lys Val Lys Thr
             590                 595                 600

 ccg tcc ttc ggc att tct gcc cct caa gtc tcc atc cct gat gtg aat     1876
 Pro Ser Phe Gly Ile Ser Ala Pro Gln Val Ser Ile Pro Asp Val Asn
         605                 610                 615

 gta aac ttg aaa gga cca aag ata aag ggt gat gtc ccc agc gtg gga     1924
 Val Asn Leu Lys Gly Pro Lys Ile Lys Gly Asp Val Pro Ser Val Gly
     620                 625                 630

 ctg gaa gga cca gat gta gat ctg caa ggt cca gaa gca aaa att aag     1972
 Leu Glu Gly Pro Asp Val Asp Leu Gln Gly Pro Glu Ala Lys Ile Lys
 635                 640                 645                 650

 ttc ccc aag ttt tcc atg ccc aag atc ggc atc cca ggt gtg aaa atg     2020
 Phe Pro Lys Phe Ser Met Pro Lys Ile Gly Ile Pro Gly Val Lys Met
                 655                 660                 665

 gag ggt ggg gga gcc gag gtc cat gcc cag cta ccc tct ctt gaa gga     2068
 Glu Gly Gly Gly Ala Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly
             670                 675                 680

 gac ttg aga gga cca gat gtt aag ctc gaa ggg ccc gat gtt tct cta     2116
 Asp Leu Arg Gly Pro Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu
         685                 690                 695

 aag ggg cca gga gta gac ttg cct tca gtg aac ctc tct atg cca aaa     2164
 Lys Gly Pro Gly Val Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys
     700                 705                 710

 gtc tct ggg cct gac ctt gat ctg aac ttg aaa gga cca agt ttg aag     2212
 Val Ser Gly Pro Asp Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys
 715                 720                 725                 730

 gga gac ctg gat gca tct gtt ccc agc atg aag gtg cat gct cca ggg     2260
 Gly Asp Leu Asp Ala Ser Val Pro Ser Met Lys Val His Ala Pro Gly
                 735                 740                 745

 ctc aac ctc agt ggt gtc ggt ggc aaa atg cag gtg gga gga gac ggt     2308
 Leu Asn Leu Ser Gly Val Gly Gly Lys Met Gln Val Gly Gly Asp Gly
             750                 755                 760

 gtg aaa gtg cca ggg atc gat gcc aca aca aag ctt aac gtt ggg gca     2356
 Val Lys Val Pro Gly Ile Asp Ala Thr Thr Lys Leu Asn Val Gly Ala
         765                 770                 775

 cca gat gtg aca ctg agg gga cca agc ctg cag gga gat ctg gct gtc     2404
 Pro Asp Val Thr Leu Arg Gly Pro Ser Leu Gln Gly Asp Leu Ala Val
     780                 785                 790

 tct ggt gac atc aaa tgc cct aaa gta tcc gta gga gct cct gat cta     2452
 Ser Gly Asp Ile Lys Cys Pro Lys Val Ser Val Gly Ala Pro Asp Leu
 795                 800                 805                 810

 agc ttg gag gca tcc gaa ggc agc att aaa ctt ccc aaa atg aag ctg     2500
 Ser Leu Glu Ala Ser Glu Gly Ser Ile Lys Leu Pro Lys Met Lys Leu
                 815                 820                 825

 ccc caa ttt ggc atc tct act ccg ggg tcc gac ttg cac gtc aat gcc     2548
 Pro Gln Phe Gly Ile Ser Thr Pro Gly Ser Asp Leu His Val Asn Ala
             830                 835                 840

 aag ggg cca cag gtt tct ggc gaa ctg aag ggg cca ggt gtg gat gtg     2596
 Lys Gly Pro Gln Val Ser Gly Glu Leu Lys Gly Pro Gly Val Asp Val
         845                 850                 855

 aac ctg aaa ggg cct cgg att tca gca ccg aat gtg gac ttt aac ttg     2644
 Asn Leu Lys Gly Pro Arg Ile Ser Ala Pro Asn Val Asp Phe Asn Leu
     860                 865                 870

 gaa gga cca aaa gtg aaa ggg agc ctt ggg gcc act ggt gag atc aaa     2692
 Glu Gly Pro Lys Val Lys Gly Ser Leu Gly Ala Thr Gly Glu Ile Lys
 875                 880                 885                 890

 ggc ccc act gtc gga gga ggt ctt cca ggc att ggt gtt caa ggc cta     2740
 Gly Pro Thr Val Gly Gly Gly Leu Pro Gly Ile Gly Val Gln Gly Leu
                 895                 900                 905

 gaa gga aac ctc cag atg cct gga att aag tcc tct gga tgt gat gtg     2788
 Glu Gly Asn Leu Gln Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val
             910                 915                 920

 aac ctg cca ggc gtg aat gtg aaa ctc cca act ggg cag att tct ggg     2836
 Asn Leu Pro Gly Val Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly
         925                 930                 935

 cct gaa atc aaa ggt ggt ctg aaa ggt tca gaa gta ggt ttc cat ggg     2884
 Pro Glu Ile Lys Gly Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly
     940                 945                 950

 gct gct cct gat atc agt gtg aag ggg cct gcc ttt aat atg gca tct     2932
 Ala Ala Pro Asp Ile Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser
 955                 960                 965                 970

 cct gag tca gat ttt ggc atc aac ttg aag ggc cca aaa atc aaa gga     2980
 Pro Glu Ser Asp Phe Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly
                 975                 980                 985

 ggt gcg gat gtt tca ggg ggt gtc agt gcc cca gac atc agc ctt ggt     3028
 Gly Ala Asp Val Ser Gly Gly Val Ser Ala Pro Asp Ile Ser Leu Gly
             990                 995                1000

 gaa ggg cat ttg agt gtt aaa ggt tcc ggg ggt gag tgg aag gga ccc     3076
 Glu Gly His Leu Ser Val Lys Gly Ser Gly Gly Glu Trp Lys Gly Pro
        1005                1010                1015

 caa gtc tcc tct gct ctc aac ttg gac aca tct aag ttt gct ggg ggc     3124
 Gln Val Ser Ser Ala Leu Asn Leu Asp Thr Ser Lys Phe Ala Gly Gly
    1020                1025                1030

 ctt cat ttc tca gga cca aag gtg gaa gga ggt gtg aaa gga ggt cag     3172
 Leu His Phe Ser Gly Pro Lys Val Glu Gly Gly Val Lys Gly Gly Gln
1035                1040                1045                1050

 att gga ctc cag gct cct ggg ctg agt gtg tct ggg cct caa ggt cac     3220
 Ile Gly Leu Gln Ala Pro Gly Leu Ser Val Ser Gly Pro Gln Gly His
                1055                1060                1065

 ttg gaa agt gga tct gga aaa gta aca ttc cct aaa atg aag atc ccc     3268
 Leu Glu Ser Gly Ser Gly Lys Val Thr Phe Pro Lys Met Lys Ile Pro
            1070                1075                1080

 aaa ttt acc ttc tct ggc cgt gag ctg gtt ggc aga gaa atg ggg gtg     3316
 Lys Phe Thr Phe Ser Gly Arg Glu Leu Val Gly Arg Glu Met Gly Val
        1085                1090                1095

 gat gtt cac ttc cct aaa gca gag gcc agc atc caa gct ggt gct gga     3364
 Asp Val His Phe Pro Lys Ala Glu Ala Ser Ile Gln Ala Gly Ala Gly
    1100                1105                1110

 gac ggc gag tgg gaa gag tct gaa gtc aaa ctg aaa aag tcc aag atc     3412
 Asp Gly Glu Trp Glu Glu Ser Glu Val Lys Leu Lys Lys Ser Lys Ile
1115                1120                1125                1130

 aaa atg ccc aag ttt aat ttt tcc aaa cct aaa ggg aaa ggt ggt gtc     3460
 Lys Met Pro Lys Phe Asn Phe Ser Lys Pro Lys Gly Lys Gly Gly Val
                1135                1140                1145

 act ggc tca cca gaa gca tca att tct ggg tcc aaa ggt gac ctg aaa     3508
 Thr Gly Ser Pro Glu Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys
            1150                1155                1160

 agt tca aag gcc agc ctg ggc tct ctg gaa gga gag gca gag gcc gaa     3556
 Ser Ser Lys Ala Ser Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu
        1165                1170                1175

 gcc tct tca ccg aaa ggc aaa ttc tcc tta ttt aaa agt aag aag cca     3604
 Ala Ser Ser Pro Lys Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro
    1180                1185                1190

 cgg cac cgc tca aat tca ttc agt gat gaa aga gag ttc tct gga cct     3652
 Arg His Arg Ser Asn Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro
1195                1200                1205                1210

 tcc acc ccg acg ggg acg ctg gag ttt gaa ggt ggg gaa gtg tct ctg     3700
 Ser Thr Pro Thr Gly Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu
                1215                1220                1225

 gaa ggt ggg aaa gtt aaa ggg aaa cac ggg aag ctg aaa ttc ggt acc     3748
 Glu Gly Gly Lys Val Lys Gly Lys His Gly Lys Leu Lys Phe Gly Thr
            1230                1235                1240

 ttt ggt gga ttg ggg tca aag agc aaa ggt cat tat gag gtg act ggg     3796
 Phe Gly Gly Leu Gly Ser Lys Ser Lys Gly His Tyr Glu Val Thr Gly
        1245                1250                1255

 agc gat gat gag aca ggc aag tta cag ggg agt ggg gtg tcc ctg gcc     3844
 Ser Asp Asp Glu Thr Gly Lys Leu Gln Gly Ser Gly Val Ser Leu Ala
    1260                1265                1270

 tct aag aag tcc cga ctg tcc tcc tct tct agc aat gac agt ggg aat     3892
 Ser Lys Lys Ser Arg Leu Ser Ser Ser Ser Ser Asn Asp Ser Gly Asn
1275                1280                1285                1290

 aag gtt ggc atc cag ctt ccc gag gtg gag ctg tca gtt tcc aca aag     3940
 Lys Val Gly Ile Gln Leu Pro Glu Val Glu Leu Ser Val Ser Thr Lys
                1295                1300                1305

 aaa gag tag caggcct ttgtatgtgt gtacatatat atatatataa caaaacatca     3996
 Lys Glu 






      <210> 182
      <211> 2238
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(1461)

      <400> 182
 gcc  atg cgt gac aac aga gct gta tcc ctc tgt cag caa gaa tgg atg      48
      Met Arg Asp Asn Arg Ala Val Ser Leu Cys Gln Gln Glu Trp Met
        1               5                  10                  15

 tgc cca ggc cct gca caa agg gcc ctc tac agg ggt gcc acc cag agg       96
 Cys Pro Gly Pro Ala Gln Arg Ala Leu Tyr Arg Gly Ala Thr Gln Arg
                  20                  25                  30

 aag gac agt cac gtc tcg ctg gca aca ggt gtg ccc tgg ggc tat gaa      144
 Lys Asp Ser His Val Ser Leu Ala Thr Gly Val Pro Trp Gly Tyr Glu
              35                  40                  45

 gag acc aag acg ctc ctg gct att ctt agt agt tct caa ttt tat gga      192
 Glu Thr Lys Thr Leu Leu Ala Ile Leu Ser Ser Ser Gln Phe Tyr Gly
          50                  55                  60

 aaa ctc cag acc tgt cag cag aac agc cag atc tac agg gcc atg gcg      240
 Lys Leu Gln Thr Cys Gln Gln Asn Ser Gln Ile Tyr Arg Ala Met Ala
      65                  70                  75

 gaa gga ctc tgg gag cag ggt ttt ctg cgg acc cca gaa cag tgt cgc      288
 Glu Gly Leu Trp Glu Gln Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg
  80                  85                  90                  95

 acc aag ttc aaa agc cta cag ttg agt tac cgc aaa gtg agg aga ggc      336
 Thr Lys Phe Lys Ser Leu Gln Leu Ser Tyr Arg Lys Val Arg Arg Gly
                 100                 105                 110

 cgt gtg cct gag cct tgt atc ttt cat gag gaa atg aat gct ctt tca      384
 Arg Val Pro Glu Pro Cys Ile Phe His Glu Glu Met Asn Ala Leu Ser
             115                 120                 125

 ggc tcc tgg gcc tct gca cct cct atg gca agc gat gct gtt cct ggc      432
 Gly Ser Trp Ala Ser Ala Pro Pro Met Ala Ser Asp Ala Val Pro Gly
         130                 135                 140

 caa gaa gga agt gat att gag gct gga gag ctg aat cac cag aat ggg      480
 Gln Glu Gly Ser Asp Ile Glu Ala Gly Glu Leu Asn His Gln Asn Gly
     145                 150                 155

 gaa ccc acg gag gta gaa gat ggc act gtg gat ggt gca gac agg gat      528
 Glu Pro Thr Glu Val Glu Asp Gly Thr Val Asp Gly Ala Asp Arg Asp
 160                 165                 170                 175

 gaa aag gac ttc agg aat cct ggc cag gaa gtc agg aaa cta gac ctg      576
 Glu Lys Asp Phe Arg Asn Pro Gly Gln Glu Val Arg Lys Leu Asp Leu
                 180                 185                 190

 cca gtg ctg ttc cca aac aga ctt ggt ttt gag ttc aag aac gag att      624
 Pro Val Leu Phe Pro Asn Arg Leu Gly Phe Glu Phe Lys Asn Glu Ile
             195                 200                 205

 aaa aaa gaa aat cta aaa tgg gat gat tca gag gaa gta gaa ata aac      672
 Lys Lys Glu Asn Leu Lys Trp Asp Asp Ser Glu Glu Val Glu Ile Asn
         210                 215                 220

 aag gct tta cag aga aag tcc aga gga gtt tat tgg cac tct gag cta      720
 Lys Ala Leu Gln Arg Lys Ser Arg Gly Val Tyr Trp His Ser Glu Leu
     225                 230                 235

 caa aaa ggc ttg gag agt gag cca aca tca aga agg caa tgt aga aat      768
 Gln Lys Gly Leu Glu Ser Glu Pro Thr Ser Arg Arg Gln Cys Arg Asn
 240                 245                 250                 255

 tct cca ggg gag agt gag gag aaa acc cca tcc cag gag aag atg agt      816
 Ser Pro Gly Glu Ser Glu Glu Lys Thr Pro Ser Gln Glu Lys Met Ser
                 260                 265                 270

 cac cag agt ttt tgt gcc agg gac aaa gcc tgt aca cat atc ctc tgt      864
 His Gln Ser Phe Cys Ala Arg Asp Lys Ala Cys Thr His Ile Leu Cys
             275                 280                 285

 ggg aaa aac tgc tct cag agt gtg cac tct ccc cac aag cca gcg ctc      912
 Gly Lys Asn Cys Ser Gln Ser Val His Ser Pro His Lys Pro Ala Leu
         290                 295                 300

 aaa ctg gaa aaa gta tct caa tgt cct gaa tgt ggg aaa acc ttt agc      960
 Lys Leu Glu Lys Val Ser Gln Cys Pro Glu Cys Gly Lys Thr Phe Ser
     305                 310                 315

 cga agt tct tat ctt gtt cgg cat caa aga atc cac aca ggc gag aag     1008
 Arg Ser Ser Tyr Leu Val Arg His Gln Arg Ile His Thr Gly Glu Lys
 320                 325                 330                 335

 cct cac aag tgc agt gag tgc ggg aag ggc ttt agt gag cgc tcc aac     1056
 Pro His Lys Cys Ser Glu Cys Gly Lys Gly Phe Ser Glu Arg Ser Asn
                 340                 345                 350

 ctc act gcc cac cta cga act cac aca ggg gag agg ccc tat cag tgt     1104
 Leu Thr Ala His Leu Arg Thr His Thr Gly Glu Arg Pro Tyr Gln Cys
             355                 360                 365

 ggg caa tgt ggg aaa agc ttc aac cag agt tcc agc ctc att gtc cac     1152
 Gly Gln Cys Gly Lys Ser Phe Asn Gln Ser Ser Ser Leu Ile Val His
         370                 375                 380

 cag agg acc cat acc ggg gaa aag cct tac cag tgc att gtc tgt gga     1200
 Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Ile Val Cys Gly
     385                 390                 395

 aag aga ttc aac aac agt tcc cag ttc agt gct cac cgg cgc atc cac     1248
 Lys Arg Phe Asn Asn Ser Ser Gln Phe Ser Ala His Arg Arg Ile His
 400                 405                 410                 415

 act ggg gag agc cca tac aag tgt gca gtg tgt ggg aaa atc ttc aat     1296
 Thr Gly Glu Ser Pro Tyr Lys Cys Ala Val Cys Gly Lys Ile Phe Asn
                 420                 425                 430

 aat agc tcc cac ttc agt gcc cac cga aaa acc cac act ggt gaa aag     1344
 Asn Ser Ser His Phe Ser Ala His Arg Lys Thr His Thr Gly Glu Lys
             435                 440                 445

 cct tac agg tgt tct cac tgt gag aga ggc ttc act aag aac tct gcc     1392
 Pro Tyr Arg Cys Ser His Cys Glu Arg Gly Phe Thr Lys Asn Ser Ala
         450                 455                 460

 ctc acc cgt cat cag aca gta cac atg aaa gca gta ctc tca tca cag     1440
 Leu Thr Arg His Gln Thr Val His Met Lys Ala Val Leu Ser Ser Gln
     465                 470                 475

 gaa gga aga gat gcg tta tga gt gtgtcggtaa actgtcagat taagttcctc     1493
 Glu Gly Arg Asp Ala Leu 
 480                 485

 aggtcagcat gtatgagctt tcttctgctg tggagagatc tagccagtcc ctgactttgc   1553

 aacagaccta ctgactactg gatcttaaga cccatgtcta ggaccaggag tcagcataag   1613

 gacgctgacc tctcctggct gtgcctgtga ctccagagtc ctatcttact gtgacttaaa   1673

 gtttgatgga gagaaagctg taggatccat aaattctacc aggaaaccag ggtcttcctg   1733

 ttcctagcac tgagaatggg cacccagtgg tccaagaaca ctttctgggc taacatagtc   1793

 ctcacacagg gctgagaaag aaagtgtctc ctttcctgga aagcacatgt aaaagttaag   1853

 ggcctgaatc tcttctaaac caataattga cctctaggca cccaccataa tactgctacc   1913

 ttcagggcag aagacactgc tctttgtaac ccagccacca ccaaaaagca aacagaaaga   1973

 aggaaggatg gttaagccat tggataatac tgaatctgtt tccctaagtg acttaacctt   2033

 agagcaagca caacatccag gttaattttt tgtaagattt ctccttttat tattgccctc   2093

 atcatagttc ctgattgtct cttaaagtaa gtggtttata gacattacta tttctgataa   2153

 taatttacaa actactataa acaaatttat aaacattact aatttctgat gaaaataaag   2213

 ttgtttctcc ctccaaaaaa aaaaa                                         2238




      <210> 183
      <211> 892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(842)

      <400> 183
 cgcacctcaa aacttaaggg ccaagcccca agaggccatt gacccccacc ctgcttccca     60

 cccaccctcc acaacaagag ccccatgagt cctgattcaa gagccagccg gtaacc        116                                                                 
 atg gaa acc atg aac tcc tcc tgg gtg agc gag ccc tgt ggc agt ggg      164
 Met Glu Thr Met Asn Ser Ser Trp Val Ser Glu Pro Cys Gly Ser Gly
   1               5                  10                  15

 ggc atg ctg ggt ttg ctg gcg tca gag gga tgg gac gct gga cct ggt      212
 Gly Met Leu Gly Leu Leu Ala Ser Glu Gly Trp Asp Ala Gly Pro Gly
              20                  25                  30

 cat tgt agc cca tca agg ccc gac ggc tgt tct tgg ggc cca gga acc      260
 His Cys Ser Pro Ser Arg Pro Asp Gly Cys Ser Trp Gly Pro Gly Thr
          35                  40                  45

 tat tca cca gca tgg tcc atc cga gag aga aat ggg ccc aac cga cag      308
 Tyr Ser Pro Ala Trp Ser Ile Arg Glu Arg Asn Gly Pro Asn Arg Gln
      50                  55                  60

 act atg ggg gct ccg gca acc agg cgc tgc gtg gag tgg ctg ctg ggc      356
 Thr Met Gly Ala Pro Ala Thr Arg Arg Cys Val Glu Trp Leu Leu Gly
  65                  70                  75                  80

 ctc tac ttc ctc agc cac atc ccc atc acc ctg ttc atg gac ctg cag      404
 Leu Tyr Phe Leu Ser His Ile Pro Ile Thr Leu Phe Met Asp Leu Gln
                  85                  90                  95

 gcg gtg ctg ccg cgc gag ctc tac cca gtc gag ttt aga aac ctg ctg      452
 Ala Val Leu Pro Arg Glu Leu Tyr Pro Val Glu Phe Arg Asn Leu Leu
             100                 105                 110

 aag tgg tat gct aag gag ttc aaa gac cca ctg cta cag gag ccc cca      500
 Lys Trp Tyr Ala Lys Glu Phe Lys Asp Pro Leu Leu Gln Glu Pro Pro
         115                 120                 125

 gcc tgg ttt aag tcc ttt ctg ttt tgc gag ctt gtg ttt cag ctg cct      548
 Ala Trp Phe Lys Ser Phe Leu Phe Cys Glu Leu Val Phe Gln Leu Pro
     130                 135                 140

 ttc ttt ccc att gca acg tat gcc ttc ctc aaa gga agc tgc aag tgg      596
 Phe Phe Pro Ile Ala Thr Tyr Ala Phe Leu Lys Gly Ser Cys Lys Trp
 145                 150                 155                 160

 att cga act cct gca atc atc tac tct gtt cac acc atg aca acc tta      644
 Ile Arg Thr Pro Ala Ile Ile Tyr Ser Val His Thr Met Thr Thr Leu
                 165                 170                 175

 att ccg ata ctc tcc aca ttt ctg ttt gag gat ttc tcc aaa gcc agt      692
 Ile Pro Ile Leu Ser Thr Phe Leu Phe Glu Asp Phe Ser Lys Ala Ser
             180                 185                 190

 ggt ttc aag gga caa aga cct gag act ttg cat gaa cgg tta acc ctt      740
 Gly Phe Lys Gly Gln Arg Pro Glu Thr Leu His Glu Arg Leu Thr Leu
         195                 200                 205

 gtg tct gtc tat gcc ccc tac tta ctc atc cca ttc ata ctt tta att      788
 Val Ser Val Tyr Ala Pro Tyr Leu Leu Ile Pro Phe Ile Leu Leu Ile
     210                 215                 220

 ttc atg ttg cgg agc ccc tac tac aag tat gaa gag aaa aga aaa aaa      836
 Phe Met Leu Arg Ser Pro Tyr Tyr Lys Tyr Glu Glu Lys Arg Lys Lys
 225                 230                 235                 240

 aaa tga aggaaacaac cactggccca gggtagagat gcctacaggg tggttgcttg       892
 Lys 






      <210> 184
      <211> 1875
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (400)..(813)

      <400> 184
 acagctgggc cctggggcca ggctgcgtgg caggactgcc agtgtgtgca gggtgctgcg     60

 tggccaagct gctgtctcag ctgcagcgct tcgatcgcac ccaccggtgc cccttccccc    120

 atgtggtgcg agctggcgcc atcttcgtgc ccattcacct ggtgaaggag cggctcttcc    180

 ctcggctgcc acccgcttct gtggaccatg tgctgcagga gcatcgtgtg gagctgcggc    240

 ccaccacgct gtcggaggag cgggcactgc gggagctcgc cctgccaggc tgcacctcac    300

 gcatgctgaa gttactggcg ctgcgccagc tgccggacat ttaccccgac cttctcggcc    360

 tgcagtggcg cgactgtgta cgccgccagc tgggtgagc   atg ggg cag ccc cag     414
                                              Met Gly Gln Pro Gln
                                                1               5

 tgg cca ccg gag ctg tgt gag caa gtg aca ggt gac ttt gac act gag      462
 Trp Pro Pro Glu Leu Cys Glu Gln Val Thr Gly Asp Phe Asp Thr Glu
                  10                  15                  20

 gct gga gct gtg tcc tcc tca gag ccc act gtg gcc aga gat gag cca      510
 Ala Gly Ala Val Ser Ser Ser Glu Pro Thr Val Ala Arg Asp Glu Pro
              25                  30                  35

 gag agc cta gcc ctg gct cag aag tca ccg gcc ccc aag gtc agg aag      558
 Glu Ser Leu Ala Leu Ala Gln Lys Ser Pro Ala Pro Lys Val Arg Lys
          40                  45                  50

 cca ggc agg aag cca cca acc cct ggc ccg gag aaa gca gag gca gct      606
 Pro Gly Arg Lys Pro Pro Thr Pro Gly Pro Glu Lys Ala Glu Ala Ala
      55                  60                  65

 gct ggg gaa gag tcc tgt ggt gcc tcc cct acc cct gct acc agt gcc      654
 Ala Gly Glu Glu Ser Cys Gly Ala Ser Pro Thr Pro Ala Thr Ser Ala
  70                  75                  80                  85

 agc cca cct ggc ccc aca ctg aag gcc cgc ttc cgc agt ctg ctg gag      702
 Ser Pro Pro Gly Pro Thr Leu Lys Ala Arg Phe Arg Ser Leu Leu Glu
                  90                  95                 100

 acc gcc tgg ctc aat ggc ctg gct ctg ccc acc tgg ggc cac aag tcc      750
 Thr Ala Trp Leu Asn Gly Leu Ala Leu Pro Thr Trp Gly His Lys Ser
             105                 110                 115

 tca aga cca gac cag ccc tca ccc tgc cca cag ctg ctg gac agc cag      798
 Ser Arg Pro Asp Gln Pro Ser Pro Cys Pro Gln Leu Leu Asp Ser Gln
         120                 125                 130

 agc cat cac ctg tag cactggttgc cagtgctgtg tgtatagcag tcactctcca      853
 Ser His His Leu 
     135

 cccttccctt ctgcctgccc agctgccccg gggccacgag tggatgctgg ggctgtggct    913

 gctcccctgg aggggttcca tctctgaccc tgtggcccat tcagggtggg ctgaagagcc    973

 cctgagcttt taacgtgagg gtctttattg gataggacta ctccctattt cttgcctaga   1033

 gaacacacat gggctttgga gcccgacaga cctgggcttg aatcccggct cgtgttcttg   1093

 ctgcaggacc tgggcaagaa acttcacctc tgctgagccc tcattcccca tgtgtaaaat   1153

 gggacaacgc aacctacctc acagggttgt tgtggggatg ctgcctgata cataccctgt   1213

 caccatttgg tctctgcttc ctctctggga cagggcctag aattggaggc agagaacctt   1273

 cctatagaaa gtcttcgtgt gtcctaggac ttggctatcg tagagtggta ccttaggcag   1333

 tggatgtgac tcacactttc aggagtcacc ccccagcatt tggggttggg ttggccctac   1393

 tccagcctgg agctccctga gggagcctgc actccctgct cccaatcccc gctactggtg   1453

 cagggatgca gcctggagct ggcgtccttg ttctgggcct gctgctgccg ccaccccagg   1513

 aggccccagg cctgtcctga attgacatca gtgcttccct gaactgcctc ccccacccct   1573

 ggcattatcc caggaaactt atgttttcta gaagctaagc agctgctggg actcagggac   1633

 tggtgcaggt aggctgagtg gcagctcagt cctagaaggt ctctgaagat ctggactgag   1693

 gaccctgcta ctccccaagc cagagcccat cagccaggcc tgctgtgagc cacctgcctg   1753

 tggagtgctg agctcaacca aaggctggca agctctgggc ctcatttaag ggattctgat   1813

 gagccgatgg gccctggagg cagcccatta aagcatctgg ctcgtttttg gaaaaaaaaa   1873

 aa                                                                  1875




      <210> 185
      <211> 1595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(639)

      <400> 185
 tagtctctgc acttgtctcc cattaaggtc ccatcc  atg ggg ggg cgg aag cgg      54
                                          Met Gly Gly Arg Lys Arg
                                            1               5

 gag cgc aag gct gcc gtc gag gag gac acc tcc ctg tcg gag agt gag      102
 Glu Arg Lys Ala Ala Val Glu Glu Asp Thr Ser Leu Ser Glu Ser Glu
              10                  15                  20

 ggg ccc cgc cag ccc gat ggg gat gag gag gag agc aca gcc ctc agc      150
 Gly Pro Arg Gln Pro Asp Gly Asp Glu Glu Glu Ser Thr Ala Leu Ser
          25                  30                  35

 atc aac gag gag atg cag cgc atg ctc aac cag ctg agg gag tat gat      198
 Ile Asn Glu Glu Met Gln Arg Met Leu Asn Gln Leu Arg Glu Tyr Asp
      40                  45                  50

 ttt gag gac gac tgt gac agc ctg act tgg gag gag act gag gag acc      246
 Phe Glu Asp Asp Cys Asp Ser Leu Thr Trp Glu Glu Thr Glu Glu Thr
  55                  60                  65                  70

 ctg ctg ctt tgg gag gat ttc tca ggc tat gcc atg gca gct gca gag      294
 Leu Leu Leu Trp Glu Asp Phe Ser Gly Tyr Ala Met Ala Ala Ala Glu
                  75                  80                  85

 gcc cag gga gag cag cag gaa gat agc ctg gag aag gtg att aaa gat      342
 Ala Gln Gly Glu Gln Gln Glu Asp Ser Leu Glu Lys Val Ile Lys Asp
              90                  95                 100

 acg gag tcc ctg ttc aaa acc cgg gag aag gag tat cag gag acc att      390
 Thr Glu Ser Leu Phe Lys Thr Arg Glu Lys Glu Tyr Gln Glu Thr Ile
         105                 110                 115

 gac cag ata gag ctg gag ttg gcc acg gcc aag aac gac atg aac cgg      438
 Asp Gln Ile Glu Leu Glu Leu Ala Thr Ala Lys Asn Asp Met Asn Arg
     120                 125                 130

 cac ctg cac gag tac atg gag atg tgc agc atg aag cgc ggc ctg gac      486
 His Leu His Glu Tyr Met Glu Met Cys Ser Met Lys Arg Gly Leu Asp
 135                 140                 145                 150

 gtg cag atg gag acc tgc cgc cgg ctc atc acc cag tct gga gac cga      534
 Val Gln Met Glu Thr Cys Arg Arg Leu Ile Thr Gln Ser Gly Asp Arg
                 155                 160                 165

 aag tct cct gct ttc act gcg gtc ccg ctt agc gac ccg ccg ccg ccg      582
 Lys Ser Pro Ala Phe Thr Ala Val Pro Leu Ser Asp Pro Pro Pro Pro
             170                 175                 180

 cca agc gag gct gag gac tcc gat cgc gat gtc tca tct gac agc tcc      630
 Pro Ser Glu Ala Glu Asp Ser Asp Arg Asp Val Ser Ser Asp Ser Ser
         185                 190                 195

 atg aga tag agacctg cctccccctt gcacccgagg ccctcgcagc agggagctca      686
 Met Arg 
     200

 gcgaggcaga gggtggggct gcacagaggg gaacatcagc tgcagctctg caccaggccg    746

 gtccctgggg actggggcgc tcctccctca ggctttctcc ctcagtcttg gcttctccag    806

 ggctctgggg tgtctggagc taggcttggc cctaccattc tggggccatt tccaccacag    866

 ttggggctct cctgccttca cgcgtgggtg tctgctactt ccccatcttt aaaatgctgc    926

 cagagcgatt gcggcccctc accttgtcca cgtatcagga atgtgaatgt gggacctttc    986

 ctccatccct gttgtccgga gccagctcag ctgtcttcca cactggtgct aactggccca   1046

 ggcactggag tggaatagaa tgcagctgga ggctacgcat ggcctctgca gcacacgcag   1106

 ctggagaggg cttctgtccc tgtcagcggc agagggcgtt ggggctggcc ggggcacctt   1166

 gtccctgcta tggtccacat gctcacgctg tccacctgcc aggtggagtg tatgtggctg   1226

 tggccctccc tcgtggaggt gccgtgcttt aaagaggcct tagtgcccgg gatgggcaca   1286

 gtgttttgaa gggaggtggg agctcttgct ctcctggtca ctgcagaatg acagagaagg   1346

 tgaagctcca tgcatgtgtg cgcgggtgta tgtgcgctca gggtctctgt ttaagtatca   1406

 gctaaagatg tgcttcctcc gtgtctgtca tacactgaga ccaacaggct acagtgtccc   1466

 tgattcttgg aaaagcctgg agaagctggg gagatgcggt tcacaatgcc tcggtatagg   1526

 aggctgtgtt gagctgacat tcaaatggat tctttaataa taatgaaact ggcgagtaaa   1586

 aaaaaaaaa                                                           1595




      <210> 186
      <211> 1684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(827)

      <400> 186
 gcgatagctg tggatgtttc caaggattgt cttcagtc    atg gcc ttg gga tta      53
                                              Met Ala Leu Gly Leu
                                                1               5

 aag tgc ttc cgc atg gtc cac cct acc ttt cgc aat tat ctt gca gcc      101
 Lys Cys Phe Arg Met Val His Pro Thr Phe Arg Asn Tyr Leu Ala Ala
                  10                  15                  20

 tct atc aga ccc gtt tca gaa gtt aca ctg aag aca gtg cat gaa aga      149
 Ser Ile Arg Pro Val Ser Glu Val Thr Leu Lys Thr Val His Glu Arg
              25                  30                  35

 caa cat ggc cat agg caa tac atg gcc tat tca gct gta cca gtc cgc      197
 Gln His Gly His Arg Gln Tyr Met Ala Tyr Ser Ala Val Pro Val Arg
          40                  45                  50

 cat ttt gct acc aag aaa gcc aaa gcc aaa ggg aaa gga cag tcc caa      245
 His Phe Ala Thr Lys Lys Ala Lys Ala Lys Gly Lys Gly Gln Ser Gln
      55                  60                  65

 acc aga gtg aat att aat gct gcc ttg gtt gag gat ata atc aac ttg      293
 Thr Arg Val Asn Ile Asn Ala Ala Leu Val Glu Asp Ile Ile Asn Leu
  70                  75                  80                  85

 gaa gag gtg aat gaa gaa atg aag tct gtg ata gaa gct ctc aag gat      341
 Glu Glu Val Asn Glu Glu Met Lys Ser Val Ile Glu Ala Leu Lys Asp
                  90                  95                 100

 aat ttc aat aag act ctc aat ata agg acc tca cca gga tcc ctt gac      389
 Asn Phe Asn Lys Thr Leu Asn Ile Arg Thr Ser Pro Gly Ser Leu Asp
             105                 110                 115

 aag att gct gtg gta act gct gac ggg aag ctt gct tta aac cag att      437
 Lys Ile Ala Val Val Thr Ala Asp Gly Lys Leu Ala Leu Asn Gln Ile
         120                 125                 130

 agc cag atc tcc atg aag tcg cca cag ctg att ttg gtg aat atg gcc      485
 Ser Gln Ile Ser Met Lys Ser Pro Gln Leu Ile Leu Val Asn Met Ala
     135                 140                 145

 agc ttc cca gag tgt aca gct gca gct atc aag gct ata aga gaa agt      533
 Ser Phe Pro Glu Cys Thr Ala Ala Ala Ile Lys Ala Ile Arg Glu Ser
 150                 155                 160                 165

 gga atg aat ctg aac cca gaa gtg gaa ggg acg cta att cgg gta ccc      581
 Gly Met Asn Leu Asn Pro Glu Val Glu Gly Thr Leu Ile Arg Val Pro
                 170                 175                 180

 att ccc caa gta acc aga gag cac aga gaa atg ctg gtg aaa ctg gcc      629
 Ile Pro Gln Val Thr Arg Glu His Arg Glu Met Leu Val Lys Leu Ala
             185                 190                 195

 aaa cag aac acc aac aag gcc aaa gac tct tta cgg aag gtt cgc acc      677
 Lys Gln Asn Thr Asn Lys Ala Lys Asp Ser Leu Arg Lys Val Arg Thr
         200                 205                 210

 aac tca atg aac aag ctg aag aaa tcc aag gat aca gtc tca gag gac      725
 Asn Ser Met Asn Lys Leu Lys Lys Ser Lys Asp Thr Val Ser Glu Asp
     215                 220                 225

 acc att agg cta ata gag aaa cag atc agc caa atg gcc gat gac aca      773
 Thr Ile Arg Leu Ile Glu Lys Gln Ile Ser Gln Met Ala Asp Asp Thr
 230                 235                 240                 245

 gtg gca gaa ctg gac agg cat ctg gca gtg aag acc aaa gaa ctc ctt      821
 Val Ala Glu Leu Asp Arg His Leu Ala Val Lys Thr Lys Glu Leu Leu
                 250                 255                 260

 gga tga aagtccactg gggccagcaa tactccagag cccagtttct gctggatccc       877
 Gly 


 atgggtggca cattgggact tctctccctc ccccatctac acagaagact gtcaccatgc    937

 tgacagaagc ctgtccttgt aaggcccagc cttccagggg aacactcaga catgttcatt    997

 ctcttcctgc ttctgctctg ggccggtggg tggctctcag aaaatacttg ctgctggcaa   1057

 aaggcctgta ctcaggcatt tgctttgact tgatgttgcc aagggactga ggccattggc   1117

 aggcttagta ccacctgctc ctcatcttag gagtctcctt ttcaaataat taggctctgt   1177

 tcccatttta aaactctgat attggccttc acctgtgact ggacacttta ctagaggccc   1237

 attttcacta aacaataaaa tctaaataaa ttggaaggaa taacaaccac aaaggaaaga   1297

 atagagttgg tctggattga tgatcactga ggatctgtat gtgaggcacc cataacagta   1357

 gttttgcctg tgagtcgtct tcacacatgc tgttttctct gcctggctct ctcttcccct   1417

 ccttacctgg ccagtcctgt ttatcatcag gccttgtctt ggatatcacg tcctctggga   1477

 agtcttcttt tcccctctaa cctaggaccc tcattaccgg ctctcatagc acagtctact   1537

 gctttgtacg aattctaagt attcttgttg cacttaatta gcctgtatat cctcagaact   1597

 ttgtgtaatg cctggagcat agtaggcagt catatgttgt atcgtgaata aattgcacat   1657

 agtagctacc cagcaaaaaa aaaaaaa                                       1684




      <210> 187
      <211> 1056
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(521)

      <400> 187
 gcaagggccg cagccagcac cgggcggaga gggctacc    atg ggg aaa atc gcg      53
                                              Met Gly Lys Ile Ala
                                                1               5

 ctg caa ctc aaa gcc acg ctg gag aac atc acc aac ctc cgg ccc gtg      101
 Leu Gln Leu Lys Ala Thr Leu Glu Asn Ile Thr Asn Leu Arg Pro Val
                  10                  15                  20

 ggc gag gac ttc cgg tgg tac ctg aag atg aaa tgt ggc aac tgt ggt      149
 Gly Glu Asp Phe Arg Trp Tyr Leu Lys Met Lys Cys Gly Asn Cys Gly
              25                  30                  35

 gag att tcg gac aag tgg cag tac atc cgg ctg atg gac agt gtg gca      197
 Glu Ile Ser Asp Lys Trp Gln Tyr Ile Arg Leu Met Asp Ser Val Ala
          40                  45                  50

 ctg aag ggg ggc cgt ggc agt gct tcc atg gtc cag aag tgc aag ctg      245
 Leu Lys Gly Gly Arg Gly Ser Ala Ser Met Val Gln Lys Cys Lys Leu
      55                  60                  65

 tgt gca aga gaa aat tcc atc gag att tta agc agc acc atc aag cct      293
 Cys Ala Arg Glu Asn Ser Ile Glu Ile Leu Ser Ser Thr Ile Lys Pro
  70                  75                  80                  85

 tac aat gct gaa gac aat gag aac ttc aag aca ata gtg gag ttt gag      341
 Tyr Asn Ala Glu Asp Asn Glu Asn Phe Lys Thr Ile Val Glu Phe Glu
                  90                  95                 100

 tgc cgg ggc ctt gaa cca gtt gat ttc cag ccg cag gct ggg ttt gct      389
 Cys Arg Gly Leu Glu Pro Val Asp Phe Gln Pro Gln Ala Gly Phe Ala
             105                 110                 115

 gct gaa ggt gtg gag tca ggg aca gcc ttc agt gac att aat ctg cag      437
 Ala Glu Gly Val Glu Ser Gly Thr Ala Phe Ser Asp Ile Asn Leu Gln
         120                 125                 130

 gag aag gac tgg act gac tat gat gaa aag gcc cag gag tct gtg gga      485
 Glu Lys Asp Trp Thr Asp Tyr Asp Glu Lys Ala Gln Glu Ser Val Gly
     135                 140                 145

 atc tat gag gtc acc cac cag ttt gtg aag tgc tga tccc tcttccttcc      535
 Ile Tyr Glu Val Thr His Gln Phe Val Lys Cys 
 150                 155                 160

 cagttgccct taagaactga gaaaggacaa agtactctaa gcagcagagc ccacagaggc    595

 tcgttccttt gacccttgtc tcctggtggc tatacgaaac cttcacaatc tgcatgctgg    655

 actttattac agcttcccaa gccccatcaa taaagcccct gttcacgctg cactggtgca    715

 tgaaggtgaa gtaaggaggc agctactccc tccacaaata agaattcgtg cagcagcagt    775

 tcactcctta ggaaaatgaa gagtattttt aaggagatgg tatctcccca gtcaagggca    835

 agtttacaga gatgaaaccg cgatcccacc atcactcaat gagccagaag ccaatggtga    895

 cgtactgtta cctgaactta ctgaacttgc tgttggaaag atctttgtga ggattaggaa    955

 ttaggttaaa agaaattaag aaccatcttc aagcaaaaat taaactttat ttctgcttaa   1015

 acaataaata cacctgagtt agttttccaa aaaaaaaaaa a                       1056




      <210> 188
      <211> 873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(304)

      <400> 188
 aggagaacgt aaaggaactg catgacatga ttacgccaag cttggcacga ggcgacaagg     60

 cacctcctgg tgtctaactc ccccaaagac aatgagttaa gggagagaat aagaacggcg    120

 gtaacagtta ttggcaaaaa gc atg aaa aga gaa agc act ttg aaa ttt att     172
                          Met Lys Arg Glu Ser Thr Leu Lys Phe Ile
                            1               5                  10

 act agc ttg cta ccc acg atg aaa tca aca acc tgt atc tgg tat cag      220
 Thr Ser Leu Leu Pro Thr Met Lys Ser Thr Thr Cys Ile Trp Tyr Gln
                  15                  20                  25

 gcc ggg aga cag atg agg cga gag gag gag gag gag gag gag aag gct      268
 Ala Gly Arg Gln Met Arg Arg Glu Glu Glu Glu Glu Glu Glu Lys Ala
              30                  35                  40

 ctg ggc tcc tct gca aaa ata aaa ata aaa aaa taa ataa aattttaaaa      318
 Leu Gly Ser Ser Ala Lys Ile Lys Ile Lys Lys 
          45                  50

 ataataaaaa ttcactatat acacatataa agaaataaaa agaagtctca gttgcagcta    378

 tttgtcaaaa ttaatatcca tttcttttta tatacggtga atattgcgca attatagatc    438

 tggattttga accacttaat gaagcggcaa caccaggtgt tttgaggtgt tggcattctt    498

 cgctgatttg gctgttccca atgtttacat tatttaatct tgcaaaaatg gttctgtgca    558

 cttggatgtg aaatgctgtc cagttttatt ttttttatgt tgttatcctt ggatgtacaa    618

 aaaattcaga aaatgatctc tgtagatatt ctgttttatt ttggtcatct ttagaagtta    678

 tcaggaatgt gtttaaaaca agacgagaac ttttctaagg aatgcataca tagcaaaaga    738

 ttttatttta aaatgagttg taaagcttgt gtttctttgt tgctgcaagc tatctgccca    798

 agttaatgca aatggacaca ttttttatgt cagaaaaaca cacacacaca cacacacaca    858

 cacacacaca cgaag                                                     873




      <210> 189
      <211> 1287
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(827)

      <220>
      <221> misc_feature
      <222> (1)...(1287)
      <223> n = a,t,c or g

      <400> 189
 ggcgggcgcg ggggctggct ggcgcggggg ctccgaccct gcccggcttg gcg   atg      56
                                                              Met
                                                                1

 gag ttt ccg gac ctc ggc gct cac tgt tcg gag ccg agc tgt cag cgc      104
 Glu Phe Pro Asp Leu Gly Ala His Cys Ser Glu Pro Ser Cys Gln Arg
               5                  10                  15

 ttg gat ttt ctg ccg ctt aag tgt gat gcc tgc tca ggc atc ttc tgc      152
 Leu Asp Phe Leu Pro Leu Lys Cys Asp Ala Cys Ser Gly Ile Phe Cys
          20                  25                  30

 gca gac cat gtg gcc tac gcc cag cat cac tgt gga tct gct tac caa      200
 Ala Asp His Val Ala Tyr Ala Gln His His Cys Gly Ser Ala Tyr Gln
      35                  40                  45

 aag gat atc cag gta cct gtg tgc cct ctc tgt aat gtg cct gtg cct      248
 Lys Asp Ile Gln Val Pro Val Cys Pro Leu Cys Asn Val Pro Val Pro
  50                  55                  60                  65

 gtg gcc aga ggg gag ccc cct gac cgt gct gtg gga gag cac att gac      296
 Val Ala Arg Gly Glu Pro Pro Asp Arg Ala Val Gly Glu His Ile Asp
                  70                  75                  80

 aga gac tgt cgc tct gat cca gca cag caa aaa cgt aag atc ttc acc      344
 Arg Asp Cys Arg Ser Asp Pro Ala Gln Gln Lys Arg Lys Ile Phe Thr
              85                  90                  95

 aat aag tgt gaa cgc gct ggc tgc cgg cag cga gaa atg atg aaa ctg      392
 Asn Lys Cys Glu Arg Ala Gly Cys Arg Gln Arg Glu Met Met Lys Leu
         100                 105                 110

 acc tgt gaa cgc tgt agc cga aac ttc tgc atc aag cac cgg cat cca      440
 Thr Cys Glu Arg Cys Ser Arg Asn Phe Cys Ile Lys His Arg His Pro
     115                 120                 125

 ctg gac cat gat tgc tct ggg gag ggg cac cca acc agc cgg gca gga      488
 Leu Asp His Asp Cys Ser Gly Glu Gly His Pro Thr Ser Arg Ala Gly
 130                 135                 140                 145

 ctt gct gcc atc tcc aga gca caa gct gtg gct tct aca agc act gtc      536
 Leu Ala Ala Ile Ser Arg Ala Gln Ala Val Ala Ser Thr Ser Thr Val
                 150                 155                 160

 ccc agc cca agt caa acc atg cct tcc tgt acc tct ccc agc aga gcc      584
 Pro Ser Pro Ser Gln Thr Met Pro Ser Cys Thr Ser Pro Ser Arg Ala
             165                 170                 175

 aca acc cga tct ccg tcc tgg aca gcc cct cca gtg att gct ttg cag      632
 Thr Thr Arg Ser Pro Ser Trp Thr Ala Pro Pro Val Ile Ala Leu Gln
         180                 185                 190

 aat ggc ctg agt gag gat gaa gct ctg cag cgg gcc ctg gaa atg tcc      680
 Asn Gly Leu Ser Glu Asp Glu Ala Leu Gln Arg Ala Leu Glu Met Ser
     195                 200                 205

 ctg gca gaa acc aaa ccc cag gtt cca agt tgt cag gag gaa gaa gac      728
 Leu Ala Glu Thr Lys Pro Gln Val Pro Ser Cys Gln Glu Glu Glu Asp
 210                 215                 220                 225

 cta gct tta gca caa gca ctg tca gcc agt gag gca gaa tac cag cgg      776
 Leu Ala Leu Ala Gln Ala Leu Ser Ala Ser Glu Ala Glu Tyr Gln Arg
                 230                 235                 240

 cac gag gcc cag agc cgc agc tcg aag ccg tcc aac tgc agc ctg tgc      824
 His Glu Ala Gln Ser Arg Ser Ser Lys Pro Ser Asn Cys Ser Leu Cys
             245                 250                 255

 tag ggcc ctgggcttgg ggagggaggt tcactgagga ggactgtggc ctcacacctc      881
 


 tagggtaaca gggagaggag cccggagcac ctggaggcag agacaacgga tgatgtgagg    941

 tccctgggac ctctgaagct tctagtctca cgtgcatgag aacggtaaac tgtcctgttg   1001

 gcctcatgat ctgcagccta tttacctcac agtattccta tatgctccgt gtgatttgaa   1061

 ggctgaaata gtcttgctta aaaaaaaatc gcgcatttct atggtattgt catccgttaa   1121

 ttatgacctt tcatatctaa tcatgaggat cagccaattc tcaaaatcgt aagccctgtg   1181

 cgantgtggg tgctatgttt tgttcaggaa catctttctt taagcgtacc aaaatgtcca   1241

 tttgattaac aatttgggga aaaactatgc ccacctcatt attttt                  1287




      <210> 190
      <211> 3936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (445)..(3882)

      <400> 190
 agtcatttat ttgcttatca ttctgcaatt tggacagtgc ttggaggggc catctcattt     60

 ctgctggcat cagctggggt agctcacctg gggctgggga gaccactccc aagatggctc    120

 atccacataa cctcagtggt tccagctgta aaatgggcac ttagatgggg tggttcttca    180

 gcatgtgacc tcccgtgtgg ctgggttgga ctcctcagaa gctgagttac aataaccaaa    240

 cagtgcattc cttggaaatt ccaaacctag atctcttgtt acatgcttgc caagcttgtc    300

 ctgaacgttc ctaagtgcag caggaaagaa gtggctcagc ttgtgctgtg tgtcccctga    360

 gtcttgacct gtgactaata actgtttcct ttgtgtgcag gggttctcta tctccagtat    420

 ggagatgaaa ccaagcagct cagg   atg ccg aat gaa atc aca agt gca gac     471
                              Met Pro Asn Glu Ile Thr Ser Ala Asp
                                1               5

 aca atc cgt gct ctc ttc gta agt gcc ttt cca cag cag ctc acc atg      519
 Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met
  10                  15                  20                  25

 aaa atg ctg gaa tcg ccc agt gtc gcc att tac atc aaa gat gaa agc      567
 Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser
                  30                  35                  40

 aga aat gtc tat tat gaa tta aat gat gta agg aac att caa gac aga      615
 Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg
              45                  50                  55

 tca ctc ctc aaa gtg tac aac aag gat cct gca cat gcg ttt aat cac      663
 Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His
          60                  65                  70

 aca cca aaa act atg aat gga gac atg agg atg cag aga gaa ctt gtt      711
 Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val
      75                  80                  85

 tat gca aga gga gat ggc cct ggg gcc cct cgc ccc gga tct act gct      759
 Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala
  90                  95                 100                 105

 cat cca ccc cat gcg att cca aat tcc cca ccg tct act cca gtg ccc      807
 His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro
                 110                 115                 120

 cat tcc atg ccc ccc tcc ccg tcc aga att cct tat ggg ggc acc cgc      855
 His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg
             125                 130                 135

 tcc atg gtt gtt cct ggc aat gcc acc atc ccc agg gac aga atc tcc      903
 Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser
         140                 145                 150

 agc ctg cca gtc tcc aga ccc atc tct cca agc cca agc gcc att tta      951
 Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu
     155                 160                 165

 gaa aga aga gat gtc aag cct gat gaa gac atg agt ggc aaa aac att      999
 Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile
 170                 175                 180                 185

 gca atg tac aga aat gag ggt ttc tat gct gat cct tac ctt tat cac     1047
 Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His
                 190                 195                 200

 gag gga cgg atg agc ata gcc tca tcc cat ggt gga cac cca ctg gat     1095
 Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp
             205                 210                 215

 gtc ccc gac cac atc att gca tat cac cgc acc gcc atc cgg tca gcg     1143
 Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala
         220                 225                 230

 agt gct tat tgt aac ccc tca atg caa gcg gaa atg cat atg gaa caa     1191
 Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln
     235                 240                 245

 tca ctg tac aga cag aaa tca agg aaa tat ccg gat agc cat ttg cct     1239
 Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro
 250                 255                 260                 265

 aca ctg ggc tcc aaa aca ccc cct gcc tct cct cac aga gtc agt gac     1287
 Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp
                 270                 275                 280

 ctg agg atg ata gac atg cac gct cac tat aat gcc cac ggc ccc cct     1335
 Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro
             285                 290                 295

 cac acc atg cag cca gac cgg gcc tct ccg agc cgc cag gcc ttt aaa     1383
 His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys
         300                 305                 310

 aag gag cca ggc acc ttg gtg tat ata gaa aag cca cgg agc gct gca     1431
 Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala
     315                 320                 325

 gga tta tcc agc ctt gta gac ctc ggc cct cct cta atg gag aag caa     1479
 Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln
 330                 335                 340                 345

 gtt ttt gcc tac agc acg gcg aca ata ccc aaa gac aga gag acc aga     1527
 Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Arg
                 350                 355                 360

 gag agg atg caa gcc atg gag aaa cag att gcc agt tta act ggc ctt     1575
 Glu Arg Met Gln Ala Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu
             365                 370                 375

 gtt cag tct gcg ctt ttt aaa ggg ccc att aca agt tat agc aaa gat     1623
 Val Gln Ser Ala Leu Phe Lys Gly Pro Ile Thr Ser Tyr Ser Lys Asp
         380                 385                 390

 gcg tct agc gag aaa atg atg aaa acc aca gcc aac agg agc cac aca     1671
 Ala Ser Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Ser His Thr
     395                 400                 405

 gat agt gca gga acg ccc cat gtg tct ggt ggg aag atg ctc agt gct     1719
 Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala
 410                 415                 420                 425

 ctg gag tcc acg gtg cct ccc agc cag cct cca cct gtg ggc acc tca     1767
 Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser
                 430                 435                 440

 gcc atc cac atg agc ctg ctt gag atg agg cgg agc gtg gcg gaa ctc     1815
 Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu
             445                 450                 455

 agg ctc cag ctc cag cag atg cgg cag ctc cag ctg cag aac cag gag     1863
 Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu
         460                 465                 470

 ttg ctg agg gca atg atg aag aag gcc gag ctg gaa atc agt ggc aaa     1911
 Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys
     475                 480                 485

 gtg atg gaa aca atg aag aga ctg gag gat ccc gtg cag cga cag cgc     1959
 Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg
 490                 495                 500                 505

 gtc cta gtg gag caa gag aga caa aaa tat ctt cat gag gaa gag aag     2007
 Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys
                 510                 515                 520

 atc gtc aag aag ttg tgc gag ttg gaa gac ttt gtt gaa gac ttg aag     2055
 Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys
             525                 530                 535

 aag gac tcc acg gca gcc agc cga ttg gtt act ctg aaa gac gtg gaa     2103
 Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu
         540                 545                 550

 gac ggg gct ttc ctc ctg cgt caa gtg gga gag gct gta gct acc ctg     2151
 Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu
     555                 560                 565

 aaa gga gaa ttt cca acc tta caa aac aag atg cga gcc atc ctg cgc     2199
 Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg
 570                 575                 580                 585

 ata gaa gtg gag gcc gtg cgg ttt ctg aag gag gag cca cac aag ctg     2247
 Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu
                 590                 595                 600

 gac agt ctc ctg aag cgt gtg cgc agc atg aca gac gtc ctg acc atg     2295
 Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met
             605                 610                 615

 ctg cgg aga cat gtc act gat ggg ctc ctg aaa ggc acg gac gca gcc     2343
 Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala
         620                 625                 630

 caa gcc gca cag tac atg gct atg gaa aag gcc aca gcc gca gaa gtc     2391
 Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val
     635                 640                 645

 ctg aag agt cag gag gag gca gcc cac acc tcc ggc cag ccc ttc cac     2439
 Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His
 650                 655                 660                 665

 agc aca ggt gcc cct ggc gat gcg aag tcg gaa gtg gtg cct ttg tcc     2487
 Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser
                 670                 675                 680

 ggc atg atg gtt cgc cac gcg cag agc tcc cct gtg gtc atc cag ccc     2535
 Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro
             685                 690                 695

 tcc cag cac tcc gtg gcc ctg ctg aac cct gct cag aac ttg cct cac     2583
 Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His
         700                 705                 710

 gtg gcc agc tcc cca gcc gtc ccc cag gaa gca acc tcc act ctg cag     2631
 Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln
     715                 720                 725

 atg tcg cag gct ccg cag tcc cca cag ata ccc atg aat ggg tct gcc     2679
 Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala
 730                 735                 740                 745

 atg cag agc ttg ttc att gaa gaa atc cac agt gtg agt gcc aag aac     2727
 Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn
                 750                 755                 760

 agg gca gtg tct atc gag aaa gca gaa aag aaa tgg gag gaa aaa agg     2775
 Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg
             765                 770                 775

 caa aat ctg gat cac tat aat ggg aaa gag ttt gag aag ctc cta gaa     2823
 Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu
         780                 785                 790

 gaa gct cag gcc aat atc atg aag tca ata cca aat ctg gag atg ccg     2871
 Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro
     795                 800                 805

 cca gcc aca ggc cca ctg cca agg gga gat gcc cca gtg gac aag gtg     2919
 Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val
 810                 815                 820                 825

 gaa ctt tca gaa gat tct cca aat tcg gaa cag gac ttg gaa aag ctg     2967
 Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu Glu Lys Leu
                 830                 835                 840

 ggg gga aag tcg ccc cct cct cct ccg cca cct cct cgt cga agc tac     3015
 Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg Arg Ser Tyr
             845                 850                 855

 ctg cca gga tcg gga ctc acc acc acg agg tca ggc gat gtg gtc tac     3063
 Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp Val Val Tyr
         860                 865                 870

 acc ggc aga aag gag aac atc acc gct aag gca agc agt gaa gat gct     3111
 Thr Gly Arg Lys Glu Asn Ile Thr Ala Lys Ala Ser Ser Glu Asp Ala
     875                 880                 885

 gga cca agc cca cag acc aga gct aca aaa tat cca gca gag gag cct     3159
 Gly Pro Ser Pro Gln Thr Arg Ala Thr Lys Tyr Pro Ala Glu Glu Pro
 890                 895                 900                 905

 gct tca gcc tgg acc cca tcc cca ccg cct gtc acc acc tcc tcc tca     3207
 Ala Ser Ala Trp Thr Pro Ser Pro Pro Pro Val Thr Thr Ser Ser Ser
                 910                 915                 920

 aag gat gag gag gaa gaa gaa gaa gaa gga gac aaa ata atg gca gaa     3255
 Lys Asp Glu Glu Glu Glu Glu Glu Glu Gly Asp Lys Ile Met Ala Glu
             925                 930                 935

 ctc cag ggc tcc agc ggg gcc cta cag acg agc agg atg cct gtc ccc     3303
 Leu Gln Gly Ser Ser Gly Ala Leu Gln Thr Ser Arg Met Pro Val Pro
         940                 945                 950

 atg agt gcc aag aac aga ccc gga acc ctg gac aaa ccc ggc aag cag     3351
 Met Ser Ala Lys Asn Arg Pro Gly Thr Leu Asp Lys Pro Gly Lys Gln
     955                 960                 965

 tcc aaa ctg cag gat ccc cgc caa tat cgt cag gct aat gga agt gct     3399
 Ser Lys Leu Gln Asp Pro Arg Gln Tyr Arg Gln Ala Asn Gly Ser Ala
 970                 975                 980                 985

 aag aaa tct ggt ggg gac ttt aag cct act tcc ccc tcc tta cct gct     3447
 Lys Lys Ser Gly Gly Asp Phe Lys Pro Thr Ser Pro Ser Leu Pro Ala
                 990                 995                1000

 tct aag att cca gcc ctt tct ccc agc tct ggg aaa agc agt tct ctg     3495
 Ser Lys Ile Pro Ala Leu Ser Pro Ser Ser Gly Lys Ser Ser Ser Leu
            1005                1010                1015

 ccc tct tct agt ggt gac agc tct aac ctc cct aat cca cct gct act     3543
 Pro Ser Ser Ser Gly Asp Ser Ser Asn Leu Pro Asn Pro Pro Ala Thr
        1020                1025                1030

 aaa cca tcg att gct tct aac cct ctc agc ccc caa aca gga cca cct     3591
 Lys Pro Ser Ile Ala Ser Asn Pro Leu Ser Pro Gln Thr Gly Pro Pro
    1035                1040                1045

 gct cac tct gcc tcc ctc atc cct tct gtc tct aat ggc tct ttg aag     3639
 Ala His Ser Ala Ser Leu Ile Pro Ser Val Ser Asn Gly Ser Leu Lys
1050                1055                1060                1065

 ttt cag agc ctc act cat aca ggt aaa ggt cac cat ctt tca ttc tca     3687
 Phe Gln Ser Leu Thr His Thr Gly Lys Gly His His Leu Ser Phe Ser
                1070                1075                1080

 ccg cag agt caa aat ggc cga gca ccc cct cct ttg tca ttt tcc tcc     3735
 Pro Gln Ser Gln Asn Gly Arg Ala Pro Pro Pro Leu Ser Phe Ser Ser
            1085                1090                1095

 tcc cct cct tct cct gcc tcc tcc gtc tca ctg aat caa ggt gcc aag     3783
 Ser Pro Pro Ser Pro Ala Ser Ser Val Ser Leu Asn Gln Gly Ala Lys
        1100                1105                1110

 ggc acc agg acc atc cat act ccc agc ctc acc agc tac aag gca cag     3831
 Gly Thr Arg Thr Ile His Thr Pro Ser Leu Thr Ser Tyr Lys Ala Gln
    1115                1120                1125

 aat gga agt tca agc aaa gcc acc cca tcc aca gca aaa gaa acc tct     3879
 Asn Gly Ser Ser Ser Lys Ala Thr Pro Ser Thr Ala Lys Glu Thr Ser
1130                1135                1140                1145

 taa aggt caaatcctat taggcacaag tcggagttac atttaaaaaa aattaacagt     3936
 






      <210> 191
      <211> 6034
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (225)..(3842)

      <400> 191
 attccccctc ctcccccggg agcggcggcg gcggccgggc cggggcccca gcgcgggccg     60

 ggagggggca cggcggaggc cacggaggca ggcgcgggag aagaccgcgc tccgcttccc    120

 gggccgcgcc gacctgctcg gcggcctgcc cgcccgcgcc caggggcccc gaacggtggg    180

 gccgggcagg cggctgaggc ctgtcccctc agttcccagg tgcc atg agg aag cct     236
                                                  Met Arg Lys Pro
                                                    1

 cgt cgg aag tcc cgg cag aat gcc gag ggc cgg cgt tcc ccg tcc ccc      284
 Arg Arg Lys Ser Arg Gln Asn Ala Glu Gly Arg Arg Ser Pro Ser Pro
   5                  10                  15                  20

 tac agt ctc aag tgc tca ccc acc cgg gag acc ctg aca tat gcc cag      332
 Tyr Ser Leu Lys Cys Ser Pro Thr Arg Glu Thr Leu Thr Tyr Ala Gln
                  25                  30                  35

 gcc cag cgg att gtc gag gta gac att gat gga cgc ctg cat cgt atc      380
 Ala Gln Arg Ile Val Glu Val Asp Ile Asp Gly Arg Leu His Arg Ile
              40                  45                  50

 agc atc tat gac cca ctc aaa atc att act gaa gat gag cta act gcc      428
 Ser Ile Tyr Asp Pro Leu Lys Ile Ile Thr Glu Asp Glu Leu Thr Ala
          55                  60                  65

 cag gat atc acc gaa tgc aat agt aac aag gaa aac agt gaa cag cct      476
 Gln Asp Ile Thr Glu Cys Asn Ser Asn Lys Glu Asn Ser Glu Gln Pro
      70                  75                  80

 cag ttc cct ggc aag tcc aag aaa ccc tca tcc aag ggc aaa aag aag      524
 Gln Phe Pro Gly Lys Ser Lys Lys Pro Ser Ser Lys Gly Lys Lys Lys
  85                  90                  95                 100

 gaa tcc tgc tcc aag cat gca tct ggt act tcc ttc cac ctc cca cag      572
 Glu Ser Cys Ser Lys His Ala Ser Gly Thr Ser Phe His Leu Pro Gln
                 105                 110                 115

 ccc agc ttc cgt atg gtg gac tca ggc atc cag cca gaa gca ccc ccg      620
 Pro Ser Phe Arg Met Val Asp Ser Gly Ile Gln Pro Glu Ala Pro Pro
             120                 125                 130

 ctg cct gct gcc tac tac cgc tac att gag aag cca cct gaa gac ctg      668
 Leu Pro Ala Ala Tyr Tyr Arg Tyr Ile Glu Lys Pro Pro Glu Asp Leu
         135                 140                 145

 gat gca gag gta gag tat gac atg gat gag gag gac ctt gcc tgg ctg      716
 Asp Ala Glu Val Glu Tyr Asp Met Asp Glu Glu Asp Leu Ala Trp Leu
     150                 155                 160

 gac atg gtg aat gaa aaa cgg cga gta gat ggg cac ggt ttg gtg tct      764
 Asp Met Val Asn Glu Lys Arg Arg Val Asp Gly His Gly Leu Val Ser
 165                 170                 175                 180

 gca gat acc ttt gag ctg ctg gta gac cgg ctt gag aaa gag tca tac      812
 Ala Asp Thr Phe Glu Leu Leu Val Asp Arg Leu Glu Lys Glu Ser Tyr
                 185                 190                 195

 ttg gag agt cgc agc agt ggg gcc caa cag tca ctc atc gat gaa gac      860
 Leu Glu Ser Arg Ser Ser Gly Ala Gln Gln Ser Leu Ile Asp Glu Asp
             200                 205                 210

 gct ttc tgc tgt gtg tgc ctg gat gat gaa tgt cac aat agc aat gtt      908
 Ala Phe Cys Cys Val Cys Leu Asp Asp Glu Cys His Asn Ser Asn Val
         215                 220                 225

 att ctc ttc tgt gac atc tgc aac ctg gct gta cac cag gag tgc tat      956
 Ile Leu Phe Cys Asp Ile Cys Asn Leu Ala Val His Gln Glu Cys Tyr
     230                 235                 240

 ggc gtc cca tac atc cct gag ggc cag tgg cta tgc cgc tgc tgc ctg     1004
 Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp Leu Cys Arg Cys Cys Leu
 245                 250                 255                 260

 cag tct ccc tcc cgg cct gtg gat tgc atc ctt tgc ccc aat aag ggt     1052
 Gln Ser Pro Ser Arg Pro Val Asp Cys Ile Leu Cys Pro Asn Lys Gly
                 265                 270                 275

 ggc gcc ttc aaa cag acc agt gat ggg cac tgg gcc cat gtg gtg tgt     1100
 Gly Ala Phe Lys Gln Thr Ser Asp Gly His Trp Ala His Val Val Cys
             280                 285                 290

 gcc atc tgg atc cct gaa gtc tgc ttt gct aac acc gtg ttc ttg gaa     1148
 Ala Ile Trp Ile Pro Glu Val Cys Phe Ala Asn Thr Val Phe Leu Glu
         295                 300                 305

 cct att gag ggc att gac aat atc ccg cct gcc cgc tgg aaa cta acc     1196
 Pro Ile Glu Gly Ile Asp Asn Ile Pro Pro Ala Arg Trp Lys Leu Thr
     310                 315                 320

 tgc tat atc tgc aag cag aaa ggg cta ggt gca gcc atc cag tgc cat     1244
 Cys Tyr Ile Cys Lys Gln Lys Gly Leu Gly Ala Ala Ile Gln Cys His
 325                 330                 335                 340

 aag gtg aac tgc tac aca gca ttc cat gtg aca tgt gca cag cgg gct     1292
 Lys Val Asn Cys Tyr Thr Ala Phe His Val Thr Cys Ala Gln Arg Ala
                 345                 350                 355

 ggg ctc ttc atg aag att gag ccc atg cgc gaa acc agc ctc aat ggc     1340
 Gly Leu Phe Met Lys Ile Glu Pro Met Arg Glu Thr Ser Leu Asn Gly
             360                 365                 370

 acc atc ttt aca gtg cgc aag act gcc tac tgt gag gcc cac tcg cca     1388
 Thr Ile Phe Thr Val Arg Lys Thr Ala Tyr Cys Glu Ala His Ser Pro
         375                 380                 385

 cca ggt gcg gcc act gct agg agg aag ggc gac tcc cct aga agc atc     1436
 Pro Gly Ala Ala Thr Ala Arg Arg Lys Gly Asp Ser Pro Arg Ser Ile
     390                 395                 400

 agt gag act ggc gat gag gaa ggg ctg aag gag ggt gat gga gag gag     1484
 Ser Glu Thr Gly Asp Glu Glu Gly Leu Lys Glu Gly Asp Gly Glu Glu
 405                 410                 415                 420

 gaa gaa gag gaa gag gtg gag gaa gaa gag cag gaa gct caa ggc ggg     1532
 Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Gln Glu Ala Gln Gly Gly
                 425                 430                 435

 gtg agt ggc tcc ctc aag gga gtg ccc aag aaa agc aag atg agt ttg     1580
 Val Ser Gly Ser Leu Lys Gly Val Pro Lys Lys Ser Lys Met Ser Leu
             440                 445                 450

 aag cag aag atc aag aag gag cca gag gaa gca ggc caa gac aca ccc     1628
 Lys Gln Lys Ile Lys Lys Glu Pro Glu Glu Ala Gly Gln Asp Thr Pro
         455                 460                 465

 tcc act ctc ccc atg ctt gct gtc cca cag ata ccc tct tac agg ttg     1676
 Ser Thr Leu Pro Met Leu Ala Val Pro Gln Ile Pro Ser Tyr Arg Leu
     470                 475                 480

 aac aag atc tgt agt ggt ctc tcc ttt cag agg aaa aac cag ttt atg     1724
 Asn Lys Ile Cys Ser Gly Leu Ser Phe Gln Arg Lys Asn Gln Phe Met
 485                 490                 495                 500

 cag cgg ctt cac aat tat tgg ctg ttg aag cgg cag gca cgg aat ggt     1772
 Gln Arg Leu His Asn Tyr Trp Leu Leu Lys Arg Gln Ala Arg Asn Gly
                 505                 510                 515

 gtc cct ctt atc cgg cgc ttg cac tcc cat ctg cag tcc caa aga aac     1820
 Val Pro Leu Ile Arg Arg Leu His Ser His Leu Gln Ser Gln Arg Asn
             520                 525                 530

 gct gag cag cga gag cag gat gag aag aca agt gca gtg aag gag gag     1868
 Ala Glu Gln Arg Glu Gln Asp Glu Lys Thr Ser Ala Val Lys Glu Glu
         535                 540                 545

 ctg aag tat tgg cag aag ctc cgg cat gac ttg gag cgg gcg cgg ctg     1916
 Leu Lys Tyr Trp Gln Lys Leu Arg His Asp Leu Glu Arg Ala Arg Leu
     550                 555                 560

 ctg att gag ctg att cgg aag aga gag aag ctc aaa cga gag cag gtc     1964
 Leu Ile Glu Leu Ile Arg Lys Arg Glu Lys Leu Lys Arg Glu Gln Val
 565                 570                 575                 580

 aaa gtc cag cag gct gcc atg gag ctg gag ctg atg cca ttc aat gtt     2012
 Lys Val Gln Gln Ala Ala Met Glu Leu Glu Leu Met Pro Phe Asn Val
                 585                 590                 595

 ctg ttg agg aca aca ctg gac ctg ctg cag gag aag gat cct gca cac     2060
 Leu Leu Arg Thr Thr Leu Asp Leu Leu Gln Glu Lys Asp Pro Ala His
             600                 605                 610

 atc ttc gca gaa cca gtc aac ttg agt gag gtt cca gat tac ctg gaa     2108
 Ile Phe Ala Glu Pro Val Asn Leu Ser Glu Val Pro Asp Tyr Leu Glu
         615                 620                 625

 ttc ata tcc aag cca atg gat ttt tct act atg agg cgg aag ctg gag     2156
 Phe Ile Ser Lys Pro Met Asp Phe Ser Thr Met Arg Arg Lys Leu Glu
     630                 635                 640

 tcc cac ctg tac cgc acc ttg gag gag ttt gag gag gac ttt aac ctt     2204
 Ser His Leu Tyr Arg Thr Leu Glu Glu Phe Glu Glu Asp Phe Asn Leu
 645                 650                 655                 660

 ata gtt acc aac tgc atg aag tat aat gct aaa gac aca att ttc cac     2252
 Ile Val Thr Asn Cys Met Lys Tyr Asn Ala Lys Asp Thr Ile Phe His
                 665                 670                 675

 cga gca gct gtc cgc ctg cgg gac ctg gga ggg gcc atc cta cgg cac     2300
 Arg Ala Ala Val Arg Leu Arg Asp Leu Gly Gly Ala Ile Leu Arg His
             680                 685                 690

 gcc cgg cgg cag gca gag aac atc ggc tat gac ccc gag agg ggc act     2348
 Ala Arg Arg Gln Ala Glu Asn Ile Gly Tyr Asp Pro Glu Arg Gly Thr
         695                 700                 705

 cac ctg ccc gag tca ccc aaa ttg gaa gac ttt tac cgc ttc tcc tgg     2396
 His Leu Pro Glu Ser Pro Lys Leu Glu Asp Phe Tyr Arg Phe Ser Trp
     710                 715                 720

 gaa gac gtg gac aac atc ctc atc cca gag aac cgg gcc cat ttg tcc     2444
 Glu Asp Val Asp Asn Ile Leu Ile Pro Glu Asn Arg Ala His Leu Ser
 725                 730                 735                 740

 cca gag gtg cag ctg aag gag ctg ctg gag aaa ctg gac ctg gtg agc     2492
 Pro Glu Val Gln Leu Lys Glu Leu Leu Glu Lys Leu Asp Leu Val Ser
                 745                 750                 755

 gcc atg cgg tcc agt ggg gcc cgc acc cgt cgt gtc cgc ctg cta cgc     2540
 Ala Met Arg Ser Ser Gly Ala Arg Thr Arg Arg Val Arg Leu Leu Arg
             760                 765                 770

 cgg gag atc aat gcc ctt cgg cag aag ctg gca cag cca cca cca cca     2588
 Arg Glu Ile Asn Ala Leu Arg Gln Lys Leu Ala Gln Pro Pro Pro Pro
         775                 780                 785

 cag cca cca tca ctc aac aag aca gta tcc aat ggg gag ctg cca gca     2636
 Gln Pro Pro Ser Leu Asn Lys Thr Val Ser Asn Gly Glu Leu Pro Ala
     790                 795                 800

 ggg ccc cag ggg gat gca gct gtg ctg gag cag gcc ttg cag gag gag     2684
 Gly Pro Gln Gly Asp Ala Ala Val Leu Glu Gln Ala Leu Gln Glu Glu
 805                 810                 815                 820

 cca gaa gac gat ggg gac aga gat gac tcc aaa ctg cct cct ccg cca     2732
 Pro Glu Asp Asp Gly Asp Arg Asp Asp Ser Lys Leu Pro Pro Pro Pro
                 825                 830                 835

 acc ctg gag ccc act ggg cct gca cct tcc ttg tct gag caa gaa tcc     2780
 Thr Leu Glu Pro Thr Gly Pro Ala Pro Ser Leu Ser Glu Gln Glu Ser
             840                 845                 850

 ccc ccg gag ccc cct act ctg aaa ccc att aat gat agc aaa cct cca     2828
 Pro Pro Glu Pro Pro Thr Leu Lys Pro Ile Asn Asp Ser Lys Pro Pro
         855                 860                 865

 agc agg ttc cta aag ccc aga aag gtg gaa gaa gat gag ctc ttg gaa     2876
 Ser Arg Phe Leu Lys Pro Arg Lys Val Glu Glu Asp Glu Leu Leu Glu
     870                 875                 880

 aaa tca cca ctg cag cta ggg aat gag cct ttg caa cgc ttg ctc agt     2924
 Lys Ser Pro Leu Gln Leu Gly Asn Glu Pro Leu Gln Arg Leu Leu Ser
 885                 890                 895                 900

 gac aat ggc atc aac aga cta tcc ctc atg gcc cct gac acc ccg gcc     2972
 Asp Asn Gly Ile Asn Arg Leu Ser Leu Met Ala Pro Asp Thr Pro Ala
                 905                 910                 915

 ggt acc cca ctt agt ggt gtg ggt cgc cgc aca tca gtc ctc ttc aag     3020
 Gly Thr Pro Leu Ser Gly Val Gly Arg Arg Thr Ser Val Leu Phe Lys
             920                 925                 930

 aag gcc aag aat ggg gtt aag cta cag aga agc ccg gac agg gtc ctg     3068
 Lys Ala Lys Asn Gly Val Lys Leu Gln Arg Ser Pro Asp Arg Val Leu
         935                 940                 945

 gag aat ggc gag gac cat ggt gtg gca ggc tct cct gcc tct cca gcc     3116
 Glu Asn Gly Glu Asp His Gly Val Ala Gly Ser Pro Ala Ser Pro Ala
     950                 955                 960

 agc atc gag gaa gag cgc cac tcc cgg aag cgg cca agg agc agg agc     3164
 Ser Ile Glu Glu Glu Arg His Ser Arg Lys Arg Pro Arg Ser Arg Ser
 965                 970                 975                 980

 tgt agt gag agc gaa ggg gag agg tcc ccc cag cag gag gaa gag aca     3212
 Cys Ser Glu Ser Glu Gly Glu Arg Ser Pro Gln Gln Glu Glu Glu Thr
                 985                 990                 995

 ggc atg acc aac ggc ttt gga aaa cac acc gaa agc ggg tct gac tct     3260
 Gly Met Thr Asn Gly Phe Gly Lys His Thr Glu Ser Gly Ser Asp Ser
            1000                1005                1010

 gaa tgt agt ttg ggt ctc agt ggt gga ctg gca ttt gaa gct tgc agt     3308
 Glu Cys Ser Leu Gly Leu Ser Gly Gly Leu Ala Phe Glu Ala Cys Ser
        1015                1020                1025

 ggt ctg acg ccc ccc aaa cgc agc cgt ggg aag cca gcc ctg tct cga     3356
 Gly Leu Thr Pro Pro Lys Arg Ser Arg Gly Lys Pro Ala Leu Ser Arg
    1030                1035                1040

 gtg ccc ttc ctg gaa ggt gtg aac gga gac tct gac tac aat ggc tca     3404
 Val Pro Phe Leu Glu Gly Val Asn Gly Asp Ser Asp Tyr Asn Gly Ser
1045                1050                1055                1060

 ggc aga agc ctc ctg ctg ccc ttt gaa gac cgc gga gac ctg gag ccc     3452
 Gly Arg Ser Leu Leu Leu Pro Phe Glu Asp Arg Gly Asp Leu Glu Pro
                1065                1070                1075

 ttg gag ctg gtg tgg gcc aag tgc cga ggc tac ccc tcc tac cct gcc     3500
 Leu Glu Leu Val Trp Ala Lys Cys Arg Gly Tyr Pro Ser Tyr Pro Ala
            1080                1085                1090

 ttg atc atc gat ccc aag atg ccc cgg gag ggc ctc ctg cac aat ggc     3548
 Leu Ile Ile Asp Pro Lys Met Pro Arg Glu Gly Leu Leu His Asn Gly
        1095                1100                1105

 gtt ccc atc cct gtc ccc ccg ctg gac gtg ctg aag ctg gga gag cag     3596
 Val Pro Ile Pro Val Pro Pro Leu Asp Val Leu Lys Leu Gly Glu Gln
    1110                1115                1120

 aaa cag gca gag gct gga gag aag ctc ttc ctt gtc ctc ttc ttt gac     3644
 Lys Gln Ala Glu Ala Gly Glu Lys Leu Phe Leu Val Leu Phe Phe Asp
1125                1130                1135                1140

 aac aag cgc acc tgg cag tgg ctt cca agg gac aaa gtc ctg ccc ttg     3692
 Asn Lys Arg Thr Trp Gln Trp Leu Pro Arg Asp Lys Val Leu Pro Leu
                1145                1150                1155

 ggt gtg gaa gac acc gtg gac aag ctc aag atg ctg gaa ggc cgc aag     3740
 Gly Val Glu Asp Thr Val Asp Lys Leu Lys Met Leu Glu Gly Arg Lys
            1160                1165                1170

 acc agc atc cgc aag tca gtg cag gtg gcc tat gac cgt gcg atg atc     3788
 Thr Ser Ile Arg Lys Ser Val Gln Val Ala Tyr Asp Arg Ala Met Ile
        1175                1180                1185

 cac ctg agc aga gtc cgg ggg ccc cac tcc ttc gtc act tcc agc tac     3836
 His Leu Ser Arg Val Arg Gly Pro His Ser Phe Val Thr Ser Ser Tyr
    1190                1195                1200

 ctg taa gggcagggct ggcctgcatc cgcttgccct gcccccatcc cgcagggcac      3892
 Leu 
1205

 agagaagcct cttctgcccc tgccagatgt atggccggca gcttccccct ctcatggtag   3952

 gccagggact gggctttctc cccactaagg gcaaggcccc agttttgacc aatcgcatgg   4012

 ttctcctggc aggcctgctg tgtgccaaaa actcccaccc aaggtccctc aggggatatt   4072

 tcactgaaga accagttaga agtagaaaca gctgtggggc ttgggcccag cttaggagat   4132

 tgcccagatg gcaagaggtc ctgggctcct tcttgagggg ctgcctggcc cgctccatcc   4192

 tactcccact aactacacct cagggcgggt gaggttccga cactgatccc agagatgccg   4252

 tggatacgcc agggtcccag ggggaatctc cccaagctca cactctctcc cgcttatcgc   4312

 ctattctcac acctcttctc ggtcccatct tctgcaccca ttgcccagtc ttgctttctc   4372

 tttcccatat tccttttctt tttctcttgt gccaaactga cagaaaccgt caccacactg   4432

 gtctttttct ttaatgtctc attccccttg aggccagctg ctatgccagg tggtgtctct   4492

 gccaggctcc tcaggcccag acagaggcca gcccacaacc tatgaccccc tcccccagga   4552

 caccacctcc cacccacaga ccttcccttt agctgttgac acaacttccc agctctgcaa   4612

 gtgtgccccc tggatcaagg cgggtcccct cttgtttttt tctttgctgc cacgaggtgg   4672

 tccaagcctt cagggtgggc tcctatcagg ctgggtgtgc gagtgtccat ctgtccacat   4732

 ggatgtcgag ggtggtttgt gtggagctgt gctcgtcagc tgggtctgcc ctcttccccc   4792

 ttttctcctt cttctctcct catggacttt ttctgcaatt gcagtcttaa gcttcactct   4852

 ccaccacctg gatggcatgg cgcctgccac caaacatctt cctggcctgc gctctgccct   4912

 gccctgccta gcctctgcta ctcccacttc ccaactccag ggaatgcatt acttttattt   4972

 caaaccctct gcctccttcc ttctttctct tcaaccccct ccccaccttc accttctcaa   5032

 aaatggaagg aaaaaaaaac tgtgaatggg gaatgctgac tgacaaacca acacaacttt   5092

 cagaggcttc agtgtctgtt ctctggacat ttcttttcac ctcctgagca ccaaagtcgc   5152

 agggccagtt gcaggccgct gattgccatg ttgattttta acctgatatt ctttttaatt   5212

 gttttaaatt tttcataggg gagttttgga caaaacagtc actggggaga tcactgccat   5272

 ttttacacac ttgacttttt aaaaatacaa ccaaccaacc accacaactt cttatacatt   5332

 tgggacatga gccagagttt aaaagggaac caacaaaaca ctataactta aaaggatggg   5392

 gttttggatt ttgtataata ataaaaacaa tacagcatat ggctagggaa ggacatggtg   5452

 tatataattg taaaatactg ttctaaatta ttcaggccta tagtttccat tactggagtc   5512

 ctccattgtg tggccacaca gtgtcgttga tttaaaggag ccagtgcttc ccctctcccc   5572

 aggtagttgg tcagctgtgg actctgtgac ctttgtctaa acctgtgttg taagatcttg   5632

 ggacttcctc tctttctatg tctatctctt ccccccaaca ctttctcttc ttagtctctc   5692

 tctttatttt tcaatctctg aatattttag tctctctctg agtctcattt tttaaaatgc   5752

 tcttttagaa cgggaaacgg ctcagatcct gctgtggcac ggggcctatg tgtctctgtc   5812

 gcgtctgctg tgaagcacat gatgctctat ttattgtaga gagtgacttt atttgctttc   5872

 tagaattgtt tataacagat ggtataagag aggtaataaa cagagaaaaa tctatgcttg   5932

 taaagaatac aaaagttaat tttacctact ataatatgac tgtctgaaac ttattttctc   5992

 tctgagaaat aaatgttcta atgggcaaaa aaaaaaaaaa aa                      6034




      <210> 192
      <211> 5878
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (323)..(2500)

      <400> 192
 ctttgaggtc ttgtggtctg attcttcaat aacatcagta accaaatctt cctctgaagt     60

 gacggaattt atttcaaagc tatgtcagct ctatcctgaa gagaacttgg agaaactcat    120

 tccttgctta gctggtccgg acgcatttta tgtggagcga aaccacgtgg atctggactc    180

 aggcctgagg tacctggcct cattaccttc tcacgtgttg aaaaatgacc atgtcaggag    240

 gtttctcagc acttcctctc ccccacagca gcttcagagt ccaagtcctg gcaatccctc    300

 cctttctaaa gtaggtaccg tg atg ggc gtg tct gga agg cct gtg tgt gga     352
                          Met Gly Val Ser Gly Arg Pro Val Cys Gly
                            1               5                  10

 gtg gct ggt atc ccg tcc tcg cag agc gga gcc cag cac cac ggg cag      400
 Val Ala Gly Ile Pro Ser Ser Gln Ser Gly Ala Gln His His Gly Gln
                  15                  20                  25

 cac ccg gcc ggc tcc gcc gcc ccc ttg cct cac tgc tcc cat gcg ggc      448
 His Pro Ala Gly Ser Ala Ala Pro Leu Pro His Cys Ser His Ala Gly
              30                  35                  40

 agc gcg ggc tca gcc ctg gcc tac cgg acc cag atg gac aca tca cct      496
 Ser Ala Gly Ser Ala Leu Ala Tyr Arg Thr Gln Met Asp Thr Ser Pro
          45                  50                  55

 gcc atc ctc atg cct tcc agt ctg cag acc cct cag acc cag gag cag      544
 Ala Ile Leu Met Pro Ser Ser Leu Gln Thr Pro Gln Thr Gln Glu Gln
      60                  65                  70

 aat ggg att cta gac tgg ctt agg aaa ctg cgt ttg cac aag tat tac      592
 Asn Gly Ile Leu Asp Trp Leu Arg Lys Leu Arg Leu His Lys Tyr Tyr
  75                  80                  85                  90

 ccc gtc ttt aag cag ctc tcc atg gag aag ttt ttg agc ctt act gaa      640
 Pro Val Phe Lys Gln Leu Ser Met Glu Lys Phe Leu Ser Leu Thr Glu
                  95                 100                 105

 gaa gat ctg aat aaa ttt gag tct ctt acc atg ggg gca aag aag aag      688
 Glu Asp Leu Asn Lys Phe Glu Ser Leu Thr Met Gly Ala Lys Lys Lys
             110                 115                 120

 ctc aag acc cag ctg gag ctg gaa aag gag aag tca gag aga cgg tgc      736
 Leu Lys Thr Gln Leu Glu Leu Glu Lys Glu Lys Ser Glu Arg Arg Cys
         125                 130                 135

 ctg aac ccc tcg gcc ccg ccg ctg gtc acc agc agt ggt gtg gct cga      784
 Leu Asn Pro Ser Ala Pro Pro Leu Val Thr Ser Ser Gly Val Ala Arg
     140                 145                 150

 gtg ccc ccc acc agc cac gtc ggg ccc gtg cag tcg ggg cgg ggc agc      832
 Val Pro Pro Thr Ser His Val Gly Pro Val Gln Ser Gly Arg Gly Ser
 155                 160                 165                 170

 cat gca gca gag ctg cgg gtg gaa gtg gag cag ccc cat cac cag ctg      880
 His Ala Ala Glu Leu Arg Val Glu Val Glu Gln Pro His His Gln Leu
                 175                 180                 185

 ccc cgg gaa ggc agt tcc tcg gag tac tcc agc tcc tcc tcc agc ccc      928
 Pro Arg Glu Gly Ser Ser Ser Glu Tyr Ser Ser Ser Ser Ser Ser Pro
             190                 195                 200

 atg ggg gta cag gcc cgg gaa gag agc tcc gac agc gct gag gag aat      976
 Met Gly Val Gln Ala Arg Glu Glu Ser Ser Asp Ser Ala Glu Glu Asn
         205                 210                 215

 gac aga cgt gtg gag att cac ttg gag agc tct gac aag gag aag ccg     1024
 Asp Arg Arg Val Glu Ile His Leu Glu Ser Ser Asp Lys Glu Lys Pro
     220                 225                 230

 gtg atg ctg ctg aat cac ttc act tcc agt tcc gcc aga ccc acg gcc     1072
 Val Met Leu Leu Asn His Phe Thr Ser Ser Ser Ala Arg Pro Thr Ala
 235                 240                 245                 250

 cag gtt ctc cct gtg cag aat gag gcc agc tcc aat cca tca ggc cac     1120
 Gln Val Leu Pro Val Gln Asn Glu Ala Ser Ser Asn Pro Ser Gly His
                 255                 260                 265

 cac ccc ctg ccc ccg cag atg ctg agc gca gcc tca cac atc aca ccc     1168
 His Pro Leu Pro Pro Gln Met Leu Ser Ala Ala Ser His Ile Thr Pro
             270                 275                 280

 atc cgc atg ctg aat tcc gtg cac aag cca gaa aga ggg agc gcg gac     1216
 Ile Arg Met Leu Asn Ser Val His Lys Pro Glu Arg Gly Ser Ala Asp
         285                 290                 295

 atg aag ctc ctc tcg tct tct gtg cac tca ctt ttg tct cta gaa gaa     1264
 Met Lys Leu Leu Ser Ser Ser Val His Ser Leu Leu Ser Leu Glu Glu
     300                 305                 310

 agg aat aaa gga tct gga cca aga agc agc atg aaa gtg gac aag agc     1312
 Arg Asn Lys Gly Ser Gly Pro Arg Ser Ser Met Lys Val Asp Lys Ser
 315                 320                 325                 330

 ttt ggc agc gcc atg atg gac gtg ctg ccc gcg tcc gca ccc cac cag     1360
 Phe Gly Ser Ala Met Met Asp Val Leu Pro Ala Ser Ala Pro His Gln
                 335                 340                 345

 cct gtg cag gtc ctc tct ggg ctt tcg gag agc agc tcc atg tca ccc     1408
 Pro Val Gln Val Leu Ser Gly Leu Ser Glu Ser Ser Ser Met Ser Pro
             350                 355                 360

 aca gtc tcc ttt ggt ccc cgg acc aaa gtc gtg cat gca tcc acg ctg     1456
 Thr Val Ser Phe Gly Pro Arg Thr Lys Val Val His Ala Ser Thr Leu
         365                 370                 375

 gac agg gtg ctg aag aca gca cag caa ccg gcc ctg gtc gtg gag acc     1504
 Asp Arg Val Leu Lys Thr Ala Gln Gln Pro Ala Leu Val Val Glu Thr
     380                 385                 390

 agc acg gcc gcc acg ggg acg ccc agc aca gtc ctc cac gcc gcc cgt     1552
 Ser Thr Ala Ala Thr Gly Thr Pro Ser Thr Val Leu His Ala Ala Arg
 395                 400                 405                 410

 ccg ccc atc aaa ctg ctg ctg tcg tca tct gtt cct gct gat tct gcc     1600
 Pro Pro Ile Lys Leu Leu Leu Ser Ser Ser Val Pro Ala Asp Ser Ala
                 415                 420                 425

 att tct ggg caa act tcc tgt cct aat aat gtg caa ata agt gtg ccc     1648
 Ile Ser Gly Gln Thr Ser Cys Pro Asn Asn Val Gln Ile Ser Val Pro
             430                 435                 440

 cct gca ata ata aac ccc cgg act gct ctg tac aca gcc aac acc aaa     1696
 Pro Ala Ile Ile Asn Pro Arg Thr Ala Leu Tyr Thr Ala Asn Thr Lys
         445                 450                 455

 gtt gcc ttt tct gca atg agc agt atg cca gtg ggc ccc ctg cag ggt     1744
 Val Ala Phe Ser Ala Met Ser Ser Met Pro Val Gly Pro Leu Gln Gly
     460                 465                 470

 ggc ttc tgt gca aac agc aac act gcc tct ccc agc agc cac ccc tcc     1792
 Gly Phe Cys Ala Asn Ser Asn Thr Ala Ser Pro Ser Ser His Pro Ser
 475                 480                 485                 490

 acg tcc ttt gcc aac atg gcc acg ttg ccc agc tgc cca gcc ccc agc     1840
 Thr Ser Phe Ala Asn Met Ala Thr Leu Pro Ser Cys Pro Ala Pro Ser
                 495                 500                 505

 tcc agc ccg gcg ctg tcc tcc gtc cct gaa agc agt ttc tat agc agc     1888
 Ser Ser Pro Ala Leu Ser Ser Val Pro Glu Ser Ser Phe Tyr Ser Ser
             510                 515                 520

 agt ggc ggt ggc ggc tcc aca gga aac att cct gcc tcg aat ccg aac     1936
 Ser Gly Gly Gly Gly Ser Thr Gly Asn Ile Pro Ala Ser Asn Pro Asn
         525                 530                 535

 cac cac cac cac cac cac cat cag cag ccc ccg gca ccc ccg cag ccc     1984
 His His His His His His His Gln Gln Pro Pro Ala Pro Pro Gln Pro
     540                 545                 550

 gcc cca ccc ccg cca ggc tgc att gtg tgc acg tcc tgt ggc tgc agc     2032
 Ala Pro Pro Pro Pro Gly Cys Ile Val Cys Thr Ser Cys Gly Cys Ser
 555                 560                 565                 570

 ggc agc tgc ggc tcg agt ggc ctg act gtc agc tac gcc aac tac ttc     2080
 Gly Ser Cys Gly Ser Ser Gly Leu Thr Val Ser Tyr Ala Asn Tyr Phe
                 575                 580                 585

 cag cac ccg ttc tcc ggt ccg tcc gtg ttc acc ttc ccc ttc ttg ccc     2128
 Gln His Pro Phe Ser Gly Pro Ser Val Phe Thr Phe Pro Phe Leu Pro
             590                 595                 600

 ttc agt ccc atg tgc agc agc ggc tac gtc agc gcc cag cag tac ggc     2176
 Phe Ser Pro Met Cys Ser Ser Gly Tyr Val Ser Ala Gln Gln Tyr Gly
         605                 610                 615

 ggc ggc tcc acc ttc ccc gtc gtg cac gcc cct tac agc agc agc ggg     2224
 Gly Gly Ser Thr Phe Pro Val Val His Ala Pro Tyr Ser Ser Ser Gly
     620                 625                 630

 acc cca gac cct gtc ctg agt ggg cag tcc acg ttt gcc gtg cca ccc     2272
 Thr Pro Asp Pro Val Leu Ser Gly Gln Ser Thr Phe Ala Val Pro Pro
 635                 640                 645                 650

 atg cag aac ttc atg gca ggg aca gca ggg gtg tac cag acc caa gga     2320
 Met Gln Asn Phe Met Ala Gly Thr Ala Gly Val Tyr Gln Thr Gln Gly
                 655                 660                 665

 ctg gtg ggc agt agc aat ggt tcc agt cac aaa aag agc ggg aac cta     2368
 Leu Val Gly Ser Ser Asn Gly Ser Ser His Lys Lys Ser Gly Asn Leu
             670                 675                 680

 tct tgt tac aac tgc ggg gcc act ggt cac cgc gcc cag gac tgc aaa     2416
 Ser Cys Tyr Asn Cys Gly Ala Thr Gly His Arg Ala Gln Asp Cys Lys
         685                 690                 695

 cag ccg tcc atg gac ttc aac cgg cca ggt act ttt agg ttg aaa tac     2464
 Gln Pro Ser Met Asp Phe Asn Arg Pro Gly Thr Phe Arg Leu Lys Tyr
     700                 705                 710

 gcc cct cca gca gaa agt ctg gac tcc aca gat tga tatt tttctctggc     2514
 Ala Pro Pro Ala Glu Ser Leu Asp Ser Thr Asp 
 715                 720                 725

 aacagaacgt tattaagcca tggagacata aggaaaatta aatacaaaac tgagaagtct   2574

 agttgctgtt gagcttaatc tttttaatcc aaaggtgctt tacttttcct agactggata   2634

 gaaaatctag cgtagaagtg catcaaactc gatttattgc caaaacccta gattggagct   2694

 tggtgtcaga actcgcctag tgggcatctc tgtggctggt gagatcggcc acctccactt   2754

 ttggttgcag tgcagagacg ccatgtctcc cgaagagcat tgccatcact ggccctccta   2814

 ggctcacacg tcaattccag ggcagctaca cgtggtctga atcgagaacc gagcttggag   2874

 ttctccaagt ggagttccac ccgccggact cctgacaccc ctgggctagg gaaaatgtcg   2934

 actttgtttt gttctgttcc taaagtgatt agcactaatc tctgggattt ttaaggattg   2994

 cactacagaa gaatgtaccc tgatgtaaat ctctgcggtt ctgggagcca aactcctctg   3054

 agaacagtca gtgcaagaga ctccaataat ccatattgaa agagtcagca ccagcagagg   3114

 ctactcgact taggacgcaa cagaggtttt agtatttcct tccctcctcc aagcacttgt   3174

 agcagtttca ggtttttaat ttttttctgc aaataaatct aaactacgtt attaaataga   3234

 aatagtttac tcgcaacaac ttaatttcta agggtccaag tcccagagaa tccatagtcg   3294

 tcaaagcttt gagagtatct ttcttcccag ccagtcagtg gctttgagcc ctatcttcca   3354

 ctacaaatga cctctcgagg ggggacggcg acagcgcggc tctgtgagtg gctgtgagga   3414

 tgctgcacgt cctcagcaga gtttgcaagt tgctttatct cccacgggct ccccaagaac   3474

 ctccaacccc gaggcttatc gctagcggat tcacacctga gacagacatt tcaacaatga   3534

 tacagtcctg tcatttatca gcaaaagatt gggaattttc tcctgtcaac ttcttttgta   3594

 ttaggctgtg tattgatagt taattccgtt aaaaattact tggaaaacag tgggaagtgg   3654

 taggactctg gaagaggcca cacacccgag agctgcgaga tctgtgcaag tctggttttg   3714

 gttaggtagt aataaaagtc ctcactgtag atctctaaat ttcaacccac ggaaatgaaa   3774

 gccttttgtc tgaaatttac ggacttaaat cttcaaggtt aaagggaatt ttctgctcaa   3834

 ataatactct tatcgaaaat gctaaagtct tcaatgttaa aatactgatt ggtaaaatct   3894

 tgcagttggg attttgcagt tggatattta ttttaaaaaa aattataata ttcagactat   3954

 tcttaaaatg ggacaatcag cctcatgaaa aattgatgta aatcagaaga ataccctaga   4014

 atgaggcctt gtgatgtgag cgttcaattt gaagagcagt tcctaacttc atagaaacta   4074

 aagcagaaag ttgttacatt ttttttatga caggctttta gtagaatttt ttagttttat   4134

 tttagttgaa ttttatttct atgcaatgca gaattaacag acctcttctc ctcatggtac   4194

 acagtattac agtgttgaag taatggtgat gcttattaca acagctattt aggggaatgt   4254

 tacgttgatc tcttaaattg taaacactac aaaatgtcaa aataatgaga actgacacaa   4314

 ctttgcctta aagagtacta gactggacct tctcatatta cgtttaagga agacttagag   4374

 tgttcattga tgtttacgat tttaatattt ctgaaggcca ttacagtggc ctggatatgt   4434

 gctgaaagcc aaacttttaa attttttggt ttttttaagc aaagaaatat tttaaataaa   4494

 tcctatttca acactgaaat tgttgaaaac cgtctcataa caaaaggaaa aaacattgga   4554

 atttttgttt tagtggtcag tataggggaa tgaaagcgtc tgttgttacc cacgtaacta   4614

 ttttgataag tattagaggt taaccttaaa tccagcaaaa cattaaaaca gaaacttttc   4674

 aacttggagc ctgccattca gcgttgaggt agatgagttc cgacactgtc acggctgtgt   4734

 tcccagcagc gaaggcctct gcggagctgc cagtcgtctt gaacgtgcat gggcggcgtg   4794

 tgacatctcc agggaggccg tccgaagtcg agaatcgtca gctgtaagta ggagctacac   4854

 agcgcagaga aaatggaacc acccatccgt gaggcctctt tccggaggga gccgcacact   4914

 tggacttgag agtttgccag cagcgagctc ggatgcatct ctccaaaagc caccaaggtc   4974

 ggcgcgtctg aagagcgttt tgcggtcatc agacttcctc atctgaaaac acagaacata   5034

 ctgacccttt caagtactta gtcattttcc tgaaagtgtg gtctgtttca gaatgctgtg   5094

 gcaaccagtg ttttatttta tgccttgctc gttgtacatc atgatgactg atggtcttca   5154

 aggttgtgag gaaagccgtc tccctgcttg actcgactgc tgtcccagag gagagtcctg   5214

 tgcgacctga gcgggggtgg ctgccatttc cagcatgcag gtgacttcca aagaatgagt   5274

 caggtggcac tgaaagccat gggttctgaa gaggcgaatt tgttgaaaag tcccaagggt   5334

 ctgaatgaaa gcatctttaa tcaacactca acactcgcaa tattctagaa aaccatatac   5394

 tgtgctggtt gaggccaaag gttaacattg ctccactgtt caccaaggaa gggggcagtg   5454

 gccatccgcc gcggcctcac gtgcgttgta acaagccctc atcacatgtg tgagtcttac   5514

 gtgcacaaaa agagaaggct ttggtactga aactggacac cttgtgtact cgataccttc   5574

 acagcttcta ttggacatat tttcttttta ggaatgaagg aaaattctcc catttttgag   5634

 ccattctttt gtcaattcta caaaattgca tgtaacttta taaatatttt taaaagatat   5694

 agttttgtaa atatttaata ttccgctaat ttgattttga attgtaaatg tcaagtattc   5754

 tgtttttggg gtttttatgt tttattatac tttgttaaaa aggacaaatt gtacattttt   5814

 agaatgtttt tatgagtaaa tttaatgtac tgaaaataaa aattttaaaa aagaaaaaaa   5874

 aaaa                                                                5878




      <210> 193
      <211> 2592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(2537)

      <400> 193
 accaccaccc gtgcgggggg atatctgagc catttctctg tgggcttttg tttttcaaag     60

 actgggcagg ttgttgttga ggtgtgtgtg ggctgccacg attttgtgga agtataatac    120

 tttgtcatta tgag  atg tcg tct ctc ggt gcc tcc ttt gtg caa att aaa     170
                  Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys
                    1               5                  10

 ttt gat gac ttg cag ttt ttt gaa aac tgc ggt gga gga agt ttt ggg      218
 Phe Asp Asp Leu Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly
          15                  20                  25

 agt gtt tat cga gcc aaa tgg ata tca cag gac aag gag gtg gct gta      266
 Ser Val Tyr Arg Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val
      30                  35                  40

 aag aag ctc ctc aaa ata gag aaa gag gca gaa ata ctc agt gtc ctc      314
 Lys Lys Leu Leu Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu
  45                  50                  55                  60

 agt cac aga aac atc atc cag ttt tat gga gta att ctt gaa cct ccc      362
 Ser His Arg Asn Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro
                  65                  70                  75

 aac tat ggc att gtc aca gaa tat gct tct ctg gga tca ctc tat gat      410
 Asn Tyr Gly Ile Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp
              80                  85                  90

 tac att aac agt aac aga agt gag gag atg gat atg gat cac att atg      458
 Tyr Ile Asn Ser Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met
          95                 100                 105

 acc tgg gcc act gat gta gcc aaa gga atg cat tat tta cat atg gag      506
 Thr Trp Ala Thr Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu
     110                 115                 120

 gct cct gtc aag gtg att cac aga gac ctc aag tca aga aac gtt gtt      554
 Ala Pro Val Lys Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val
 125                 130                 135                 140

 ata gct gct gat gga gta ttg aag atc tgt gac ttt ggt gcc tct cgg      602
 Ile Ala Ala Asp Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg
                 145                 150                 155

 ttc cat aac cat aca aca cac atg tcc ttg gtt gga act ttc cca tgg      650
 Phe His Asn His Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp
             160                 165                 170

 atg gct cca gaa gtt atc cag agt ctc cct gtg tca gaa act tgt gac      698
 Met Ala Pro Glu Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp
         175                 180                 185

 aca tat tcc tat ggt gtg gtt ctc tgg gag atg cta aca agg gag gtc      746
 Thr Tyr Ser Tyr Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val
     190                 195                 200

 ccc ttt aaa ggt ttg gaa gga tta caa gta gct tgg ctt gta gtg gaa      794
 Pro Phe Lys Gly Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu
 205                 210                 215                 220

 aaa aac gag aga tta acc att cca agc agt tgc ccc aga agt ttt gct      842
 Lys Asn Glu Arg Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala
                 225                 230                 235

 gaa ctg tta cat cag tgt tgg gaa gct gat gcc aag aaa cgg cca tca      890
 Glu Leu Leu His Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser
             240                 245                 250

 ttc aag caa atc att tca atc ctg gag tcc atg tca aat gac acg agc      938
 Phe Lys Gln Ile Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser
         255                 260                 265

 ctt cct gac aag tgt aac tca ttc cta cac aac aag gcg gag tgg agg      986
 Leu Pro Asp Lys Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg
     270                 275                 280

 tgc gaa att gag gca act ctt gag agg cta aag aaa cta gag cgt gat     1034
 Cys Glu Ile Glu Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp
 285                 290                 295                 300

 ctc agc ttt aag gag cag gag ctt aaa gaa cga gaa aga cgt tta aag     1082
 Leu Ser Phe Lys Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys
                 305                 310                 315

 atg tgg gag caa aag ctg aca gag cag tcc aac acc ccg ctg ctg cct     1130
 Met Trp Glu Gln Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro
             320                 325                 330

 tcc ttt gag att ggt gca tgg acg gaa gac gat gtg tat tgt tgg gtt     1178
 Ser Phe Glu Ile Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val
         335                 340                 345

 cag cag ctc gtc aga aaa ggt gac tct tca gca gag atg agt gta tat     1226
 Gln Gln Leu Val Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr
     350                 355                 360

 gca agc ttg ttt aaa gaa aac aac att aca ggg aag cgg ctg ctg ctg     1274
 Ala Ser Leu Phe Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu
 365                 370                 375                 380

 ctg gag gaa gaa gac ctg aaa gac atg ggc att gtc tcc aag ggg cat     1322
 Leu Glu Glu Glu Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His
                 385                 390                 395

 atc att cac ttc aag tca gcc att gag aaa tta acc cat gat tac ata     1370
 Ile Ile His Phe Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile
             400                 405                 410

 aat ttg ttt cac ttc cca cca cta att aag gac tca gga ggt gaa cct     1418
 Asn Leu Phe His Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro
         415                 420                 425

 gaa gaa aat gag gaa aaa ata gtg aac ctg gaa ctg gtt ttt ggt ttt     1466
 Glu Glu Asn Glu Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe
     430                 435                 440

 cac ttg aaa cca gga act ggc cca cag gat tgt aag tgg aaa atg tat     1514
 His Leu Lys Pro Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr
 445                 450                 455                 460

 atg gag atg gat ggg gat gaa att gca ata acc tac ata aaa gat gtg     1562
 Met Glu Met Asp Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val
                 465                 470                 475

 aca ttc aac act aac cta cct gat gcg gag att tta aag atg aca aag     1610
 Thr Phe Asn Thr Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys
             480                 485                 490

 cca cca ttt gta atg gag aag tgg att gta gga ata gca aaa agt cag     1658
 Pro Pro Phe Val Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln
         495                 500                 505

 act gtg gag tgc act gtc aca tat gag agt gat gtt aga act cca aaa     1706
 Thr Val Glu Cys Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys
     510                 515                 520

 agc act aaa cat gtc cat ttg att cag tgg agt aga aca aaa cct cag     1754
 Ser Thr Lys His Val His Leu Ile Gln Trp Ser Arg Thr Lys Pro Gln
 525                 530                 535                 540

 gat gaa gtg aaa gca gtc caa ctt gcc att cag aca tta ttc acc aat     1802
 Asp Glu Val Lys Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn
                 545                 550                 555

 tca gat ggc aac cct gga agc agg tcc gac tca agt gct gat tgc cag     1850
 Ser Asp Gly Asn Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln
             560                 565                 570

 tgg tta gat act ctg agg atg cgg cag att gca tcc aac act tct tta     1898
 Trp Leu Asp Thr Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu
         575                 580                 585

 cag cgt tcc cag agc aat cct att ctg ggg tca ccg ttc ttc tca cac     1946
 Gln Arg Ser Gln Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His
     590                 595                 600

 ttt gat ggc cag gat tcc tac gct gct gct gtg aga cgg ccc cag gtg     1994
 Phe Asp Gly Gln Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val
 605                 610                 615                 620

 ccc att aag tat caa cag att aca cct gtg aac cag tcc aga agc tcg     2042
 Pro Ile Lys Tyr Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser
                 625                 630                 635

 tct cct act cag tat gga ctg acc aaa aac ttc tct tcc cta cat ctc     2090
 Ser Pro Thr Gln Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu
             640                 645                 650

 aac tct agg gac agt ggc ttt tcc agt ggc aat act gac acc tct tca     2138
 Asn Ser Arg Asp Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser
         655                 660                 665

 gag agg ggt cga tac tca gac aga agc agg aac aaa tat gga cgt ggt     2186
 Glu Arg Gly Arg Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly
     670                 675                 680

 agt ata tca ctc aat tct tct cct aga gga aga tac agt gga aag agt     2234
 Ser Ile Ser Leu Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser
 685                 690                 695                 700

 cag cat tcc act cct tca aga gga aga tac cct gga aag ttc tac agg     2282
 Gln His Ser Thr Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg
                 705                 710                 715

 gtt tct cag tca gca ctc aat cct cac cag tcg cct gac ttc aag aga     2330
 Val Ser Gln Ser Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg
             720                 725                 730

 agc ccc agg gac ctc cac caa ccc aac acc ata cca ggg atg cct ttg     2378
 Ser Pro Arg Asp Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu
         735                 740                 745

 cac cct gag act gac tca aga gcc agt gaa gag gac agc aaa gtc agc     2426
 His Pro Glu Thr Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser
     750                 755                 760

 gaa ggg ggc tgg aca aaa gtg gaa tac cgg aaa aag ccc cac agg cca     2474
 Glu Gly Gly Trp Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro
 765                 770                 775                 780

 tct ccc gcc aaa acc aat aaa gag aga gcc aga ggg gac cac cgt gga     2522
 Ser Pro Ala Lys Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly
                 785                 790                 795

 tgg aga aac ttt tga tgaattgaac tacatagctt ttctaagcag gttaaaaaaa     2577
 Trp Arg Asn Phe 
             800

 aaaaaaaaaa aaaaa                                                    2592




      <210> 194
      <211> 1833
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(1595)

      <400> 194
 gagtccatcg cccgtccctt cggaacggcg ctcgcccatc tctcaggacc gactgaccc      59                                                                 
 atg ttc aac tgc tgt tca cat gga acc ctt ctc cac ttc ggc ctt caa      107
 Met Phe Asn Cys Cys Ser His Gly Thr Leu Leu His Phe Gly Leu Gln
   1               5                  10                  15

 agt tcc gtt gaa gcc gtc acg gct tca acg gaa ctt ttg ggc agg tgt      155
 Ser Ser Val Glu Ala Val Thr Ala Ser Thr Glu Leu Leu Gly Arg Cys
              20                  25                  30

 cag cgc ccg tgt cac cgc cac gtc gcg gac atg gtg att tca gaa agt      203
 Gln Arg Pro Cys His Arg His Val Ala Asp Met Val Ile Ser Glu Ser
          35                  40                  45

 atg gat ata ctc ttc aga ata aga gga ggc ctt gat ttg gct ttt cag      251
 Met Asp Ile Leu Phe Arg Ile Arg Gly Gly Leu Asp Leu Ala Phe Gln
      50                  55                  60

 cta gct act cct aat gaa att ttt ctc aag aag gca ctg aaa cat gtg      299
 Leu Ala Thr Pro Asn Glu Ile Phe Leu Lys Lys Ala Leu Lys His Val
  65                  70                  75                  80

 ttg agt gac ctg tca act aag ctg tct tca aac gcc ctt gtg ttc aga      347
 Leu Ser Asp Leu Ser Thr Lys Leu Ser Ser Asn Ala Leu Val Phe Arg
                  85                  90                  95

 att tgc cac agt tca gtg tat ata tgg cct agc agt gac ata aac acc      395
 Ile Cys His Ser Ser Val Tyr Ile Trp Pro Ser Ser Asp Ile Asn Thr
             100                 105                 110

 att cct gga gaa ctg act gat gct tct gct tgt aag aac ata ctg cgc      443
 Ile Pro Gly Glu Leu Thr Asp Ala Ser Ala Cys Lys Asn Ile Leu Arg
         115                 120                 125

 ttt att caa ttt gag cca gaa gaa gat ata aaa aga aaa ttc atg aga      491
 Phe Ile Gln Phe Glu Pro Glu Glu Asp Ile Lys Arg Lys Phe Met Arg
     130                 135                 140

 aag aag gac aaa aag tta tca gac atg cat caa ata gta aat ata gat      539
 Lys Lys Asp Lys Lys Leu Ser Asp Met His Gln Ile Val Asn Ile Asp
 145                 150                 155                 160

 ctt atg ctg gaa atg tca acc tcc ctg gca gct gta acg ccc atc att      587
 Leu Met Leu Glu Met Ser Thr Ser Leu Ala Ala Val Thr Pro Ile Ile
                 165                 170                 175

 gaa agg gaa agc gga gga cac cat tat gtt aat atg act tta cct gtc      635
 Glu Arg Glu Ser Gly Gly His His Tyr Val Asn Met Thr Leu Pro Val
             180                 185                 190

 gat gca gtt ata tct gtt gct cca gaa gaa aca tgg gga aaa gtt cgt      683
 Asp Ala Val Ile Ser Val Ala Pro Glu Glu Thr Trp Gly Lys Val Arg
         195                 200                 205

 aaa ctc ctg gtt gat gca att cat aat caa cta act gac atg gaa aaa      731
 Lys Leu Leu Val Asp Ala Ile His Asn Gln Leu Thr Asp Met Glu Lys
     210                 215                 220

 tgt att ttg aaa tat atg aaa gga aca tct att gtg gtc cct gaa cca      779
 Cys Ile Leu Lys Tyr Met Lys Gly Thr Ser Ile Val Val Pro Glu Pro
 225                 230                 235                 240

 ctg cac ttt tta tta cca ggg aaa aaa aat ctt gta aca att tca tat      827
 Leu His Phe Leu Leu Pro Gly Lys Lys Asn Leu Val Thr Ile Ser Tyr
                 245                 250                 255

 cct tca gga ata cca gat ggc cag ctg cag gcc tat agg aag gag tta      875
 Pro Ser Gly Ile Pro Asp Gly Gln Leu Gln Ala Tyr Arg Lys Glu Leu
             260                 265                 270

 cat gat ctt ttc aat ctg cct cac gac aga ccc tat ttc aaa agg tct      923
 His Asp Leu Phe Asn Leu Pro His Asp Arg Pro Tyr Phe Lys Arg Ser
         275                 280                 285

 aat gct tat cac ttt cca gat gag cca tac aaa gat ggt tac att aga      971
 Asn Ala Tyr His Phe Pro Asp Glu Pro Tyr Lys Asp Gly Tyr Ile Arg
     290                 295                 300

 aat cca cat act tac ctt aat cca cct aac atg gag act ggt atg att     1019
 Asn Pro His Thr Tyr Leu Asn Pro Pro Asn Met Glu Thr Gly Met Ile
 305                 310                 315                 320

 tat gtg gtc cag ggc ata tat ggc tat cat cat tat atg cag gat cgc     1067
 Tyr Val Val Gln Gly Ile Tyr Gly Tyr His His Tyr Met Gln Asp Arg
                 325                 330                 335

 ata gat gac aat ggc tgg ggc tgt gct tat cga tct ctg cag act atc     1115
 Ile Asp Asp Asn Gly Trp Gly Cys Ala Tyr Arg Ser Leu Gln Thr Ile
             340                 345                 350

 tgc tct tgg ttc aaa cat cag gga tac aca gag agg tcc att cca aca     1163
 Cys Ser Trp Phe Lys His Gln Gly Tyr Thr Glu Arg Ser Ile Pro Thr
         355                 360                 365

 cac aga gaa att cag cag gct cta gtc gat gcc ggg gac aaa cca gca     1211
 His Arg Glu Ile Gln Gln Ala Leu Val Asp Ala Gly Asp Lys Pro Ala
     370                 375                 380

 aca ttt gtc gga tcg cgg caa tgg att gga tct att gag gtg cag ctg     1259
 Thr Phe Val Gly Ser Arg Gln Trp Ile Gly Ser Ile Glu Val Gln Leu
 385                 390                 395                 400

 gta cta aac caa ttg atc ggt ata acg tca aaa atc ctg ttt gtc agc     1307
 Val Leu Asn Gln Leu Ile Gly Ile Thr Ser Lys Ile Leu Phe Val Ser
                 405                 410                 415

 caa ggt tca gaa att gcc tct caa gga cgg gaa ctg gct aat cat ttc     1355
 Gln Gly Ser Glu Ile Ala Ser Gln Gly Arg Glu Leu Ala Asn His Phe
             420                 425                 430

 caa agt gaa gga act cca gtt atg atc ggg gga gga gtt ttg gcc cac     1403
 Gln Ser Glu Gly Thr Pro Val Met Ile Gly Gly Gly Val Leu Ala His
         435                 440                 445

 aca ata cta gga gtt gca tgg aat gag att aca ggg cag ata aag ttt     1451
 Thr Ile Leu Gly Val Ala Trp Asn Glu Ile Thr Gly Gln Ile Lys Phe
     450                 455                 460

 ctg att cta gat cca cat tat acc ggt gct gaa gac ctg caa gtt att     1499
 Leu Ile Leu Asp Pro His Tyr Thr Gly Ala Glu Asp Leu Gln Val Ile
 465                 470                 475                 480

 ttg gaa aag ggc tgg tgc gga tgg aag ggc cca gat ttt tgg aac aag     1547
 Leu Glu Lys Gly Trp Cys Gly Trp Lys Gly Pro Asp Phe Trp Asn Lys
                 485                 490                 495

 gat gca tac tat aac tta tgt ctt cct cag cga cca aat atg att taa     1595
 Asp Ala Tyr Tyr Asn Leu Cys Leu Pro Gln Arg Pro Asn Met Ile 
             500                 505                 510

 aatatcttgg agtcaaagac tgcagtagag tggtattata aatttgtgaa taaagaatca   1655

 gtttaatttt tcacattaaa tcctggttct agtttgacca tttaaattat gacctttttc   1715

 aaaggttgta aatactgcac ggagaatgta ttttttagac gttcctttaa taacttaaaa   1775

 gacaaagcat acccaaccag catattatag gcatgtaaat acatgtgttc ttaaatgg     1833




      <210> 195
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(1115)

      <400> 195
 ctggaaggtt tcctgtggag atagccaatg agatagatgg aacgttttct tcctctggtt     60

 gcctaaatgg aagtttttta gctgttagca atgatgatca ctatagaaca ggtaccagat    120

 tttcaggggt tgat  atg aat gct gct agg ctt tta ttc cac aaa ctt ata     170
                  Met Asn Ala Ala Arg Leu Leu Phe His Lys Leu Ile
                    1               5                  10

 caa cct gat cat ccg cag ata tct cag cag gtg gca gct agt ttg gaa      218
 Gln Pro Asp His Pro Gln Ile Ser Gln Gln Val Ala Ala Ser Leu Glu
          15                  20                  25

 aag aat ctt att cct aaa ctg act agc tcc tta cct gat gtt gag gca      266
 Lys Asn Leu Ile Pro Lys Leu Thr Ser Ser Leu Pro Asp Val Glu Ala
      30                  35                  40

 ttg agg ttt tat ctt act cta cca gaa tgt ccc ctg atg agt gat tcc      314
 Leu Arg Phe Tyr Leu Thr Leu Pro Glu Cys Pro Leu Met Ser Asp Ser
  45                  50                  55                  60

 aac aat ttc aca aca ata gca att ccc ttt ggt aca gct ctt gtg aac      362
 Asn Asn Phe Thr Thr Ile Ala Ile Pro Phe Gly Thr Ala Leu Val Asn
                  65                  70                  75

 cta gaa aag gca cca ctg aaa gta ctt gaa aac tgg tgg tca gta ctt      410
 Leu Glu Lys Ala Pro Leu Lys Val Leu Glu Asn Trp Trp Ser Val Leu
              80                  85                  90

 gaa cct cca cta ttc ctc aag ata gta gaa ctt ttt aag gaa gtt gtg      458
 Glu Pro Pro Leu Phe Leu Lys Ile Val Glu Leu Phe Lys Glu Val Val
          95                 100                 105

 gta cat ctt ttg aaa ctc tac aag atc ggt att ccc cct tct gaa aga      506
 Val His Leu Leu Lys Leu Tyr Lys Ile Gly Ile Pro Pro Ser Glu Arg
     110                 115                 120

 aga att ttc aac agt ttt ctt cat act gca tta aag gtt tta gaa ata      554
 Arg Ile Phe Asn Ser Phe Leu His Thr Ala Leu Lys Val Leu Glu Ile
 125                 130                 135                 140

 cta cat agg gta aat gag aaa atg gga cag att ata cag tat gat aaa      602
 Leu His Arg Val Asn Glu Lys Met Gly Gln Ile Ile Gln Tyr Asp Lys
                 145                 150                 155

 ttt tat ata cat gaa gta caa gaa ttg ata gac ata aga aat gat tat      650
 Phe Tyr Ile His Glu Val Gln Glu Leu Ile Asp Ile Arg Asn Asp Tyr
             160                 165                 170

 atc aac tgg gtc caa cag cag gcc tat gga atg ttg gca gat atc cct      698
 Ile Asn Trp Val Gln Gln Gln Ala Tyr Gly Met Leu Ala Asp Ile Pro
         175                 180                 185

 gtt aca atc tgt aca tat cca ttt gta ttt gat gcc caa gca aaa act      746
 Val Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr
     190                 195                 200

 act ctg tta cag acc gat gca gtc tta cag atg cag atg gct att gat      794
 Thr Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp
 205                 210                 215                 220

 cag gcc cac agg cag aat gtc tcc tct ctt ttt ctc cca gtg att gaa      842
 Gln Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu
                 225                 230                 235

 tct gtg aat ccc tgc tta att cta gtg gtg cgt aga gaa aat att gta      890
 Ser Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val
             240                 245                 250

 gga gat gca atg gaa gtc ctt agg aaa aca aag aac ata gat tac aag      938
 Gly Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys
         255                 260                 265

 aag cca ctc aag gtt ata ttt gtt gga gaa gat gct gtg gat gca gga      986
 Lys Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly
     270                 275                 280

 ggg gtg cgc aaa gaa ttt ttc ttg ctc atc atg agg gaa tta ttg gat     1034
 Gly Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp
 285                 290                 295                 300

 cct aaa tac ggc atg ttt agg tat tat gaa gat tcc agg ctc att tgg     1082
 Pro Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp
                 305                 310                 315

 ttt tct gat aag gta aaa tgt cca acc atc taa attacttc tgtgtatata     1133
 Phe Ser Asp Lys Val Lys Cys Pro Thr Ile 
             320                 325

 cccatgtatt tatacctgta tgtatcaagt taattcagta aataaggaat tactactgga   1193

 tccctaacat ataagatctg ctttattaca atttgagaaa ttataaactt tggacttgga   1253

 gttgtcaaaa tacatttgat gcttaccaca cattttaaat taacaaaata aattaagaga   1313

 tggttagcca gaaaataatg ttgactattc cttctgctga tttcaatttg aggattgaat   1373

 aataatcacc agattaactt ttctgttggg aaaaattaat ttatcattag ggatcattga   1433

 tttatctacc ttgtcattta gagcaggtca gcggactata gcccattaat ctc          1486




      <210> 196
      <211> 1147
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(1097)

      <400> 196
 tactactact aaattcgcgg ccgctcgacc tgaccagcac c    atg gcg gtt ggc      53
                                                  Met Ala Val Gly
                                                    1

 aag aac aag cgc ctt acg aaa ggc ggc aaa aag gga gcc aag aag aaa      101
 Lys Asn Lys Arg Leu Thr Lys Gly Gly Lys Lys Gly Ala Lys Lys Lys
   5                  10                  15                  20

 gtg gtt gat cca ttt tct aag aaa gat tgg tat gat gtg aaa gca cct      149
 Val Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Val Lys Ala Pro
                  25                  30                  35

 gct atg ttc aat ata aga aat att gga aag acg ctc gtc acc agg acc      197
 Ala Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Leu Val Thr Arg Thr
              40                  45                  50

 caa gga acc aaa att gca tct gat ggt ctc aag ggt cgt gtg ttt gaa      245
 Gln Gly Thr Lys Ile Ala Ser Asp Gly Leu Lys Gly Arg Val Phe Glu
          55                  60                  65

 gtg agt ctt gct gat ttg cag aat gat gaa gtt gca ttt aga aaa ttc      293
 Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Val Ala Phe Arg Lys Phe
      70                  75                  80

 aag ctg att act gaa gat gtt cag ggt aaa aac tgc ctg act aac ttc      341
 Lys Leu Ile Thr Glu Asp Val Gln Gly Lys Asn Cys Leu Thr Asn Phe
  85                  90                  95                 100

 cat ggc atg gat ctt acc cgt gac aaa atg tgt tcc atg gtc aaa aaa      389
 His Gly Met Asp Leu Thr Arg Asp Lys Met Cys Ser Met Val Lys Lys
                 105                 110                 115

 tgg cag aca atg att gaa gct cac gtt gat gtc aag act acc gat ggt      437
 Trp Gln Thr Met Ile Glu Ala His Val Asp Val Lys Thr Thr Asp Gly
             120                 125                 130

 tac ttg ctt cgt ctg ttc tgt gtt ggt ttt act aaa aaa cgc aac aat      485
 Tyr Leu Leu Arg Leu Phe Cys Val Gly Phe Thr Lys Lys Arg Asn Asn
         135                 140                 145

 cag ata cgg aag acc tct tat gct cag cac caa cag gtc cgc caa atc      533
 Gln Ile Arg Lys Thr Ser Tyr Ala Gln His Gln Gln Val Arg Gln Ile
     150                 155                 160

 cgg aag aag atg atg gaa atc atg acc cga gag gtg cag aca aat gac      581
 Arg Lys Lys Met Met Glu Ile Met Thr Arg Glu Val Gln Thr Asn Asp
 165                 170                 175                 180

 ttg aaa gaa gtg gtc aat aaa ttg att cca gac agc att gga aaa gac      629
 Leu Lys Glu Val Val Asn Lys Leu Ile Pro Asp Ser Ile Gly Lys Asp
                 185                 190                 195

 ata gaa aag gct tgc caa tct att tat cct ctc cat gat gtc ttc gtt      677
 Ile Glu Lys Ala Cys Gln Ser Ile Tyr Pro Leu His Asp Val Phe Val
             200                 205                 210

 aga aaa gta aaa atg ctg aag aag ccc aag ttt gaa ttg gga aag ctc      725
 Arg Lys Val Lys Met Leu Lys Lys Pro Lys Phe Glu Leu Gly Lys Leu
         215                 220                 225

 atg gag ctt cat ggt gaa ggc agt agt tct gga aaa gcc act ggg gac      773
 Met Glu Leu His Gly Glu Gly Ser Ser Ser Gly Lys Ala Thr Gly Asp
     230                 235                 240

 gag aca ggt gct aaa gtt gaa cga gct gat gga tat gaa cca cca gtc      821
 Glu Thr Gly Ala Lys Val Glu Arg Ala Asp Gly Tyr Glu Pro Pro Val
 245                 250                 255                 260

 caa gaa tct gtt aaa ggt aga att cac tgg gcg cct ata agg cgt att      869
 Gln Glu Ser Val Lys Gly Arg Ile His Trp Ala Pro Ile Arg Arg Ile
                 265                 270                 275

 gcg ggg gtg aca aga aca aaa ggg ggg ggc gcc aaa aat acc ccc cgg      917
 Ala Gly Val Thr Arg Thr Lys Gly Gly Gly Ala Lys Asn Thr Pro Arg
             280                 285                 290

 ggg ggc cac gaa tat gta cca cgt ttg tgt aac agg ccc caa aga gcg      965
 Gly Gly His Glu Tyr Val Pro Arg Leu Cys Asn Arg Pro Gln Arg Ala
         295                 300                 305

 gtg ata aca aca agc aag cgg ggg tac aca acc tgg aaa aaa tca cag     1013
 Val Ile Thr Thr Ser Lys Arg Gly Tyr Thr Thr Trp Lys Lys Ser Gln
     310                 315                 320

 gcc tta atg aga acc acc tgg gtg tat gtg aac aca cca act aac ctc     1061
 Ala Leu Met Arg Thr Thr Trp Val Tyr Val Asn Thr Pro Thr Asn Leu
 325                 330                 335                 340

 gat aac ata cag cac gac att tgc acg cta acg tag ctat ataagaatcg     1111
 Asp Asn Ile Gln His Asp Ile Cys Thr Leu Thr 
                 345                 350

 acaagacacc agttaatcat ataacgaata gtaagt                             1147




      <210> 197
      <211> 807
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(568)

      <400> 197
 taagcttgcg gccgccggac gggccgctcc cggcctcgcg gcctcgcctc cccacactac     60

 aactcccacg gggcagcggg cgcggctccc cgtacccacc agctggccgg gcagggcagc    120

 cacttcgcgg tcgggcccgc cggctgcggg cacccgcgcg acgggcggga ag    atg     175
                                                              Met
                                                                1

 gcg gac gtg gtc gtg ggt aaa gac aag ggc ggg gag caa cgg ctc atc      223
 Ala Asp Val Val Val Gly Lys Asp Lys Gly Gly Glu Gln Arg Leu Ile
               5                  10                  15

 tcg ctg cct cta tcc cgc atc cgg gtc atc atg aag agc tcc ccc gag      271
 Ser Leu Pro Leu Ser Arg Ile Arg Val Ile Met Lys Ser Ser Pro Glu
          20                  25                  30

 gtg tcc agc atc aac cag gag gcg ttg gtg ctc acg gcc aag gcc acg      319
 Val Ser Ser Ile Asn Gln Glu Ala Leu Val Leu Thr Ala Lys Ala Thr
      35                  40                  45

 gag ctc ttt gtt caa tgc cta gcc acc tat tcc tac aga cac ggc agt      367
 Glu Leu Phe Val Gln Cys Leu Ala Thr Tyr Ser Tyr Arg His Gly Ser
  50                  55                  60                  65

 gga aag gaa aag aaa gta ctg act tac agt gat tta gca aac act gca      415
 Gly Lys Glu Lys Lys Val Leu Thr Tyr Ser Asp Leu Ala Asn Thr Ala
                  70                  75                  80

 cag caa tca gaa act ttt cag ttt ctt gca gat ata tta cca aag aag      463
 Gln Gln Ser Glu Thr Phe Gln Phe Leu Ala Asp Ile Leu Pro Lys Lys
              85                  90                  95

 att tta gct agt aaa tac ctg aaa atg ctt aaa gag gaa aag agg gaa      511
 Ile Leu Ala Ser Lys Tyr Leu Lys Met Leu Lys Glu Glu Lys Arg Glu
         100                 105                 110

 gaa gat gag gag aat gac aat gat aat gaa agt gac cat gat gaa gct      559
 Glu Asp Glu Glu Asn Asp Asn Asp Asn Glu Ser Asp His Asp Glu Ala
     115                 120                 125

 gac tcc taa accaaaa gtgctttaaa aaccagcctg gcgaggacag ccctggaccc      615
 Asp Ser 
 130

 actccactgt ctctaagtaa acacagcact gcccgctttt agcgtcttca cttcttcaca    675

 gagttccagt gcgtggtatt ctttcgaggt attctttcca ggccgagatt gagcacctca    735

 tgtacctacg ccacagacag ccagagggaa agcgacccag acagcagccc ctcctcgaca    795

 ggcccacctt gc                                                        807




      <210> 198
      <211> 2811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(2764)

      <400> 198
 taagcttgcg gccgccggcg aggaatggcg gtatttgtga gaggagtcgg cgtttgaaga     60

 ggtggaactc ctagggcttt tttgagagtg ctgatttaga agaatacaaa tc    atg     115
                                                              Met
                                                                1

 gct gaa aat agt gta tta aca tcc act act ggg agg act agc ttg gca      163
 Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu Ala
               5                  10                  15

 gac tct tcc att ttt gat tct aaa gtt act gag att tcc aag gaa aac      211
 Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu Asn
          20                  25                  30

 tta ctt att gga tct act tca tat gta gaa gaa gag atg cct cag att      259
 Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln Ile
      35                  40                  45

 gaa aca aga gtg ata ttg gtt caa gaa gct gga aaa caa gaa gaa ctt      307
 Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu Leu
  50                  55                  60                  65

 ata aaa gcc tta aag gac att aaa gtg ggc ttt gta aag atg gag tca      355
 Ile Lys Ala Leu Lys Asp Ile Lys Val Gly Phe Val Lys Met Glu Ser
                  70                  75                  80

 gtg gaa gaa ttt gaa ggt ttg gat tct ccg gaa ttt gaa aat gta ttt      403
 Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val Phe
              85                  90                  95

 gta gtc acg gac ttt cag gat tct gtc ttt aat gac ctc tac aag gct      451
 Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys Ala
         100                 105                 110

 gat tgt aga gtt att gga cca cca gtt gta tta aat tgt tca caa aaa      499
 Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln Lys
     115                 120                 125

 gga gag cct ttg cca ttt tca tgt cgc ccg ttg tat tgt aca agt atg      547
 Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys Thr Ser Met
 130                 135                 140                 145

 atg aat cta gta cta tgc ttt act gga ttt aga aaa aaa gaa gaa cta      595
 Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu Leu
                 150                 155                 160

 gtc agg ttg gtg aca ttg gtc cat cac atg ggt gga gtt att cga aaa      643
 Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg Lys
             165                 170                 175

 gac ttt aat tca aaa gtt aca cat ttg gtg gca aat tgt aca caa gga      691
 Asp Phe Asn Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln Gly
         180                 185                 190

 gaa aaa ttc agg gtt gct gtg agt cta ggt act cca att atg aag cca      739
 Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys Pro
     195                 200                 205

 gaa tgg att tat aaa gct tgg gaa agg cgg aat gaa cag gat ttc tat      787
 Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe Tyr
 210                 215                 220                 225

 gca gca gtt gat gac ttt aga aat gaa ttt aaa gtt cct cca ttt caa      835
 Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe Gln
                 230                 235                 240

 gat tgt att tta agt ttc ctg gga ttt tca gat gaa gag aaa acc aat      883
 Asp Cys Ile Leu Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr Asn
             245                 250                 255

 atg gaa gaa atg act gaa atg caa gga ggt aaa tat tta ccg ctt gga      931
 Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu Gly
         260                 265                 270

 gat gaa aga tgc act cac ctt gta gtt gaa gag aat ata gta aaa gat      979
 Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys Asp
     275                 280                 285

 ctt ccc ttt gaa cct tca aag aaa ctt tat gtt gtc aag caa gag tgg     1027
 Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu Trp
 290                 295                 300                 305

 ttc tgg gga agc att caa atg gat gcc cga gct gga gaa act atg tat     1075
 Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met Tyr
                 310                 315                 320

 tta tat gaa aag gca aat act cct gag ctc aag aaa tca gtg tca atg     1123
 Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser Met
             325                 330                 335

 ctt tct cta aat acc cct aac agc aat cgc aaa cga cgt cgt tta aaa     1171
 Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu Lys
         340                 345                 350

 gaa aca ctt gct cag ctt tca aga gag aca gac gtg tca cca ttt cca     1219
 Glu Thr Leu Ala Gln Leu Ser Arg Glu Thr Asp Val Ser Pro Phe Pro
     355                 360                 365

 ccc cgt aag cgc cca tca gct gag cat tcc ctt tcc ata ggg tca ctc     1267
 Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser Leu
 370                 375                 380                 385

 cta gat atc tcc aac aca cca gag tct agc att aac tat gga gac acc     1315
 Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp Thr
                 390                 395                 400

 cca aag tct tgt act aag tct tct aaa agc tcc act cca gtt cct tca     1363
 Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro Ser
             405                 410                 415

 aag cag tca gca agg tgg caa gtt gca aaa gag ctt tat caa act gaa     1411
 Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr Glu
         420                 425                 430

 agt aat tat gtt aat ata ttg gca aca att att cag tta ttt caa gta     1459
 Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln Val
     435                 440                 445

 cca ttg gaa gag gaa gga caa cgt ggt gga cct atc ctt gca cca gag     1507
 Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro Glu
 450                 455                 460                 465

 gag att aag act att ttt ggt agc atc cca gat atc ttt gat gta cac     1555
 Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val His
                 470                 475                 480

 act aag ata aag gat gat ctt gaa gac ctt ata gtt aat tgg gat gag     1603
 Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp Glu
             485                 490                 495

 agc aaa agc att ggt gac att ttt ctg aaa tat tca aaa gat ttg gta     1651
 Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu Val
         500                 505                 510

 aaa acc tac cct ccc ttt gta aac ttc ttt gaa atg agc aag gaa aca     1699
 Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu Thr
     515                 520                 525

 att att aaa tgt gaa aaa cag aaa cca aga ttt cat gct ttt ctc aag     1747
 Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu Lys
 530                 535                 540                 545

 ata aac caa gca aaa cca gaa tgt gga cgg cag agc ctt gtt gaa ctt     1795
 Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu Leu
                 550                 555                 560

 ctt atc cga cca gta cag agg tta ccc agt gtt gca tta ctt tta aat     1843
 Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu Asn
             565                 570                 575

 gat ctt aag aag cat aca gct gat gaa aat cca gac aaa agc act tta     1891
 Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr Leu
         580                 585                 590

 gaa aaa gct att gga tca ctg aag gaa gta atg acg cat att aat gag     1939
 Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn Glu
     595                 600                 605

 gat aag aga aaa aca gaa gct caa aag caa att ttt gat gtt gtt tat     1987
 Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val Tyr
 610                 615                 620                 625

 gaa gta gat gga tgc cca gct aat ctt tta tct tct cac cga agc tta     2035
 Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser Leu
                 630                 635                 640

 gta cag cgg gtt gaa aca att tct cta ggt gag cac ccc tgt gac aga     2083
 Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp Arg
             645                 650                 655

 gga gaa caa gta act ctc ttc ctc ttc aat gat tgc cta gag ata gca     2131
 Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile Ala
         660                 665                 670

 aga aaa cgg cac aag gtt att ggc act ttt agg agt cct cat ggc caa     2179
 Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly Gln
     675                 680                 685

 acc cga ccc cca gct tct ctt aag cat att cac cta atg cct ctt tct     2227
 Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu Ser
 690                 695                 700                 705

 cag att aag aag gta ttg gac ata aga gag aca gaa gat tgc cat aat     2275
 Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His Asn
                 710                 715                 720

 gct ttt gcc ttg ctt gtg agg cca cca aca gag cag gca aat gtg cta     2323
 Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val Leu
             725                 730                 735

 ctc agt ttc cag atg aca tca gat gaa ctt cca aaa gaa aac tgg cta     2371
 Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp Leu
         740                 745                 750

 aag atg ctg tgt cga cat gta gct aac acc att tgt aaa gca gat gct     2419
 Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp Ala
     755                 760                 765

 gag aat ctt att tat act gct gat cca gaa tcc ttt gaa gta aat aca     2467
 Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn Thr
 770                 775                 780                 785

 aaa gat atg gac agt aca ttg agt aga gca tca aga gca ata aaa aag     2515
 Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala Ile Lys Lys
                 790                 795                 800

 act tca aaa aag gtt aca aga gca ttc tct ttc tcc aaa act cca aaa     2563
 Thr Ser Lys Lys Val Thr Arg Ala Phe Ser Phe Ser Lys Thr Pro Lys
             805                 810                 815

 aga gct ctt cga agg gct ctt atg aca tcc cac ggc tca gtg gag gga     2611
 Arg Ala Leu Arg Arg Ala Leu Met Thr Ser His Gly Ser Val Glu Gly
         820                 825                 830

 aga agt cct tcc agc aat gat aag cat gta atg agt cgt ctt tct agc     2659
 Arg Ser Pro Ser Ser Asn Asp Lys His Val Met Ser Arg Leu Ser Ser
     835                 840                 845

 aca tca tca tta gca ggt atc cct tct ccc tcc ctt gtc agc ctt cct     2707
 Thr Ser Ser Leu Ala Gly Ile Pro Ser Pro Ser Leu Val Ser Leu Pro
 850                 855                 860                 865

 tcc ttc ttt gaa agg aga agt cat acg tta agt aga tct aca act cat     2755
 Ser Phe Phe Glu Arg Arg Ser His Thr Leu Ser Arg Ser Thr Thr His
                 870                 875                 880

 ttg ata tga agcgtta ccaaaatctt aaattataga aatgtataga cacctcatac     2811
 Leu Ile 






      <210> 199
      <211> 1338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1256)

      <400> 199
 aatggactct gacactgggc atctcgtctt tcgtactgat cacgggctgc gccaac         56                                                                 
 atg ctt ctc atg gct gcc ctg tgg ggc ctc tac atg tcc ctg gtt aat      104
 Met Leu Leu Met Ala Ala Leu Trp Gly Leu Tyr Met Ser Leu Val Asn
   1               5                  10                  15

 gtg ggc cat gtc tgg tac tct ttc gga tgg gag tcc cag ctt ctg gag      152
 Val Gly His Val Trp Tyr Ser Phe Gly Trp Glu Ser Gln Leu Leu Glu
              20                  25                  30

 acg ggg ttc ctg ggg atc ttc ctg tgc cct ctg tgg acg ctg tca agg      200
 Thr Gly Phe Leu Gly Ile Phe Leu Cys Pro Leu Trp Thr Leu Ser Arg
          35                  40                  45

 ctg ccc cag cat acc ccc aca tcc cgg att gtc ctg tgg ggc ttc cgg      248
 Leu Pro Gln His Thr Pro Thr Ser Arg Ile Val Leu Trp Gly Phe Arg
      50                  55                  60

 tgg ctg atc ttc agg atc atg ctt gga gca ggc ctg atc aag atc cgg      296
 Trp Leu Ile Phe Arg Ile Met Leu Gly Ala Gly Leu Ile Lys Ile Arg
  65                  70                  75                  80

 ggg gac cgg tgc tgg cga gac ctc acc tgc atg gac ttc cac tat gag      344
 Gly Asp Arg Cys Trp Arg Asp Leu Thr Cys Met Asp Phe His Tyr Glu
                  85                  90                  95

 acc cag ccg atg ccc aat cct gtg gcg tac tac ctg cac cac tca ccc      392
 Thr Gln Pro Met Pro Asn Pro Val Ala Tyr Tyr Leu His His Ser Pro
             100                 105                 110

 tgg tgg ttc cat cgc ttc gag acg ctc agc aac cac ttc atc gag ctc      440
 Trp Trp Phe His Arg Phe Glu Thr Leu Ser Asn His Phe Ile Glu Leu
         115                 120                 125

 ctg gtg ccc ttc ttc ctc ttc ctc ggc cgg cgg gcg tgc atc atc cac      488
 Leu Val Pro Phe Phe Leu Phe Leu Gly Arg Arg Ala Cys Ile Ile His
     130                 135                 140

 ggg gtg ctg cag atc ctg ttc cag gcc gtc ctc atc gtc agc ggg aac      536
 Gly Val Leu Gln Ile Leu Phe Gln Ala Val Leu Ile Val Ser Gly Asn
 145                 150                 155                 160

 ctc agc ttc ctg aac tgg ctg act atg gtg ccc agc ctg gcc tgc ttt      584
 Leu Ser Phe Leu Asn Trp Leu Thr Met Val Pro Ser Leu Ala Cys Phe
                 165                 170                 175

 gat gac gcc acc ctg gga ttc ttg ttc ccc tct ggg cca ggc agc ctg      632
 Asp Asp Ala Thr Leu Gly Phe Leu Phe Pro Ser Gly Pro Gly Ser Leu
             180                 185                 190

 aag gac cga gtt ctg cag atg cag agg gac atc cga ggg gcc cgg ccc      680
 Lys Asp Arg Val Leu Gln Met Gln Arg Asp Ile Arg Gly Ala Arg Pro
         195                 200                 205

 gag ccc aga ttc ggc tcc gtg gtg cgg cgt gca gcc aac gtc tcg ctg      728
 Glu Pro Arg Phe Gly Ser Val Val Arg Arg Ala Ala Asn Val Ser Leu
     210                 215                 220

 ggc gtc ctg ctg gcc tgg ctc agc gtg ccc gtg gtc ctc aac ttg ctg      776
 Gly Val Leu Leu Ala Trp Leu Ser Val Pro Val Val Leu Asn Leu Leu
 225                 230                 235                 240

 agc tcc agg cag gtc atg aac acc cac ttc aac tct ctt cac atc gtc      824
 Ser Ser Arg Gln Val Met Asn Thr His Phe Asn Ser Leu His Ile Val
                 245                 250                 255

 aac act tac ggg gcc ttc gga agc atc acc aag gag cgg gcg gag gtg      872
 Asn Thr Tyr Gly Ala Phe Gly Ser Ile Thr Lys Glu Arg Ala Glu Val
             260                 265                 270

 atc ctg cag ggc aca gcc agc tcc aac gcc agc gcc ccc gat gcc atg      920
 Ile Leu Gln Gly Thr Ala Ser Ser Asn Ala Ser Ala Pro Asp Ala Met
         275                 280                 285

 tgg gag gac tac gag ttc aag tgc aag cca gac cta cga gca caa cga      968
 Trp Glu Asp Tyr Glu Phe Lys Cys Lys Pro Asp Leu Arg Ala Gln Arg
     290                 295                 300

 ctg gat cat cca cct ggc tgg caa gct cct ggc cag cga cgc cga ggc     1016
 Leu Asp His Pro Pro Gly Trp Gln Ala Pro Gly Gln Arg Arg Arg Gly
 305                 310                 315                 320

 ctt gtc cct gct ggc aca caa ccc ctt cgc ggg cag gcc ccc gcc cag     1064
 Leu Val Pro Ala Gly Thr Gln Pro Leu Arg Gly Gln Ala Pro Ala Gln
                 325                 330                 335

 gtg ggt ccg agg aga gca cta cag gta caa gtt cag ccg tcc tgg ggg     1112
 Val Gly Pro Arg Arg Ala Leu Gln Val Gln Val Gln Pro Ser Trp Gly
             340                 345                 350

 cag gca cgc cgc cga ggg caa gtg gtg ggt gcg gaa gag gat cgg agc     1160
 Gln Ala Arg Arg Arg Gly Gln Val Val Gly Ala Glu Glu Asp Arg Ser
         355                 360                 365

 cta ctt ccc tcc gct cag cct gga gga gct gag gcc cta ctt cag gga     1208
 Leu Leu Pro Ser Ala Gln Pro Gly Gly Ala Glu Ala Leu Leu Gln Gly
     370                 375                 380

 ccg tgg gtg gcc tct gcc cgg gcc cct cta gac gtg cac cag aaa taa     1256
 Pro Trp Val Ala Ser Ala Arg Ala Pro Leu Asp Val His Gln Lys 
 385                 390                 395

 aggcgaagac ccagcccctc ggcggctcag caacgtttgc ccttccctgc gcccagccca   1316

 agctgggcat cgccaagaga ga                                            1338




      <210> 200
      <211> 2899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (547)..(1353)

      <400> 200
 cattgttaac ttgtgatctt caaactctct acatgatctt agctcctcaa actctctggt     60

 ggtccagtgt ctgtctttga agaaattagt gctatttctt ttgtaaaaaa gatcccaatt    120

 tttctgagcc tcttgttcca atttctgctg tttaaaatca gacaccaaag tttggtctct    180

 tttcagtttc tcctcttctt cagaggtgag aatccttgcc tgcagccctt tcctttgcaa    240

 agaagccatc tctgaaactg acggtaacac ttaacacagc tgaagattct ccatcaccaa    300

 ataatatgaa tccacgctaa tggatcagat acatttcctg aggtgagttt cacgcctcaa    360

 acagcacagg gggccccacg cagaggagag aacttgcttc tggacccggg tgggtgccgg    420

 ctcggctctc cttgtcttcc agagcggtgg cccggaagca cagtcctccc agacgccagc    480

 gccagaagct cggatcgcgg ctgcaccggg agagcgccga tctgggtgcg aggcaggtgc    540

 ggggcc   atg aat ggg acc gca aac ccg ctg ctg gac cgc gag gaa cat     588
          Met Asn Gly Thr Ala Asn Pro Leu Leu Asp Arg Glu Glu His
            1               5                  10

 tgc ctg agg ctc ggg gag agc ttc gag aag cgg ccg cgg gcc tcc ttc      636
 Cys Leu Arg Leu Gly Glu Ser Phe Glu Lys Arg Pro Arg Ala Ser Phe
  15                  20                  25                  30

 cac act att cgt tat gat ttt aaa cca gca tct ata gac act tcc tgt      684
 His Thr Ile Arg Tyr Asp Phe Lys Pro Ala Ser Ile Asp Thr Ser Cys
                  35                  40                  45

 gaa gga gag ctt caa gtt ggc aaa gga gat gaa gtc aca att aca ctg      732
 Glu Gly Glu Leu Gln Val Gly Lys Gly Asp Glu Val Thr Ile Thr Leu
              50                  55                  60

 cca cat atc cct gga tcc aca cca ccc atg act gtg ttc aag ggg aac      780
 Pro His Ile Pro Gly Ser Thr Pro Pro Met Thr Val Phe Lys Gly Asn
          65                  70                  75

 aaa cgg cct tac cag aaa gac tgt gtg ctt att att aat cat gac act      828
 Lys Arg Pro Tyr Gln Lys Asp Cys Val Leu Ile Ile Asn His Asp Thr
      80                  85                  90

 ggt gaa tat gtg ctg gaa aaa ctc agt agc agc att cag gtg aag aaa      876
 Gly Glu Tyr Val Leu Glu Lys Leu Ser Ser Ser Ile Gln Val Lys Lys
  95                 100                 105                 110

 aca aga gct gag ggc agc agt aaa atc cag gcc cga atg gaa cag cag      924
 Thr Arg Ala Glu Gly Ser Ser Lys Ile Gln Ala Arg Met Glu Gln Gln
                 115                 120                 125

 ccc act cgt cct cca cag acg tca cag cca cca cca cct cca cca cct      972
 Pro Thr Arg Pro Pro Gln Thr Ser Gln Pro Pro Pro Pro Pro Pro Pro
             130                 135                 140

 atg cca ttc aga gct cca acg aag cct cca gtt gga ccc aaa act tct     1020
 Met Pro Phe Arg Ala Pro Thr Lys Pro Pro Val Gly Pro Lys Thr Ser
         145                 150                 155

 ccc ttg aaa gat aac ccc tca cct gaa cct cag ttg gat gac atc aaa     1068
 Pro Leu Lys Asp Asn Pro Ser Pro Glu Pro Gln Leu Asp Asp Ile Lys
     160                 165                 170

 aga gag ctg agg gct gaa gtt gac att att gaa caa atg agc agc agc     1116
 Arg Glu Leu Arg Ala Glu Val Asp Ile Ile Glu Gln Met Ser Ser Ser
 175                 180                 185                 190

 agt ggg agc agc tct tca gac tct gag agc tct tcg gga agt gat gac     1164
 Ser Gly Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Asp
                 195                 200                 205

 gat agc tcc agc agt gga ggc gag gac aat ggc cca gcc tct cct ccg     1212
 Asp Ser Ser Ser Ser Gly Gly Glu Asp Asn Gly Pro Ala Ser Pro Pro
             210                 215                 220

 cag cct tca cac cag cag ccc tac aac agt agg cct gcc gtt gcc aat     1260
 Gln Pro Ser His Gln Gln Pro Tyr Asn Ser Arg Pro Ala Val Ala Asn
         225                 230                 235

 gga acc agc cgg cca caa gga agc aac cag ctc atg aac acc ctc aga     1308
 Gly Thr Ser Arg Pro Gln Gly Ser Asn Gln Leu Met Asn Thr Leu Arg
     240                 245                 250

 aat gac ttg cag ttg agt gag tct ggc agt gac agt gat gac tag tgc     1356
 Asn Asp Leu Gln Leu Ser Glu Ser Gly Ser Asp Ser Asp Asp 
 255                 260                 265

 tggatctttc gaaacctact ttttggtgca caaacatgcc gcaagactga gctactttgg   1416

 cgtggagtcc attgcaagag gaaaatgtta tggatcagtg actgtagtag gagtttgagg   1476

 ctctggaact ctcacatatt caagtcttta acttagtggt gatgggtgat tttctcgtgt   1536

 catttttgaa caatctcatc tttcaaagtt taagtagacc tgtagaagag ctaacagaat   1596

 tatatttcta tttagttaaa attgttaatg aaaaacagat aaatgtgccc tggtctaagt   1656

 tactcaaagg ccatatcttc accaggccag agattcagtt ttaaacctca gcagccatca   1716

 gtttggccaa gtggttggta ccagtggaat gaagtctttg atgggtagga gagagaggga   1776

 aaacctcaaa ctacatcata gaagtatgtt aaaaccactt taaattgttg acacaaagtg   1836

 gtaaggaagt tttgtctgac tcagcctgac aagcctggat agaaatggac ctcagaatac   1896

 agaatggagt ccttgagtgt cagttggtga ggaccatgga gtcctgccag ctcaacctgt   1956

 catttacaga ctaagaaagg gaagtacaca cctggcttgt ggccagtctc ctgccccctc   2016

 tctgggcttt cctcactgtt ctctcccttg aatctcattt gtaggaatca agagattcct   2076

 atacatggga cttttagatg tacattggca cttggattag attccaaaag acaaaagtgt   2136

 tgggtgcttc tagcttgaat tcagtcccta aatacatgag gctgggtgag cagatgaaac   2196

 cggtagccac tgtgctgatg catgtgactc cattcagttg gggattttgg ttccatgtgg   2256

 atccatacta agtattcttc agtcagtgga ttttagcaag gggaggtagg agtggaagag   2316

 aggtgtgaag aaacctctcc gaacaaatga accagcagta agtttctaaa aatcagaatc   2376

 tagatagaag ttctgcaata tgaaatgagc acattctttg ataaggcgta tctattcatg   2436

 cttttgtacc actgttttgt acctgactcc ctgaccgatt tgtatttttt atatacaact   2496

 agaaggaagt cacaagattg ccttctacag tgtgccattt ccaaatggat ctgttgttgg   2556

 aggaaactgg ttgctagtca atgttctata tttaatgaat gtgtgataaa tcatcctgta   2616

 atcagtatgg agtaacctgt ttttgtagtt tggatgaata tgtcctgaga aatttccatc   2676

 cactttggtt cagcggacat caaggtagta ataataattt ttcctccaca ggtccctcca   2736

 ctcatatggc ctctccctcc ccagctagtg gaggggaagc agtctggact tagaaaggaa   2796

 ataggtggtc tgtcataggg gctttcatta tagttaaact tcatatagtt aactgtatct   2856

 tcatcatatt gagcccaaat agcccctgcc caacagtatg ctc                     2899




      <210> 201
      <211> 2504
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1602)

      <220>
      <221> misc_feature
      <222> (1)...(2504)
      <223> n = a,t,c or g

      <400> 201
 ggagggagcg acaatggaaa aatcacctga aaactgggac agaggaagga agctacagtt     60

 acgaaggaga gctgcaaaag ttgcagcaga aaggttggga gtcccgacag gttccgtagc    120

 ccacagaaaa gaagcaaggg acggcaggac tgtttcacac ttttctgctt ctggaaggtg    180

 ctggacaaaa ac    atg gaa cta att tcc cca aca gtg att ata atc ctg     228
                  Met Glu Leu Ile Ser Pro Thr Val Ile Ile Ile Leu
                    1               5                  10

 ggt tgc ctt gct ctg ttc tta ctc ctt cag cgg aag aat ttg cgt aga      276
 Gly Cys Leu Ala Leu Phe Leu Leu Leu Gln Arg Lys Asn Leu Arg Arg
          15                  20                  25

 ccc ccg tgc atc aag ggc tgg att cct tgg att gga gtt gga ttt gag      324
 Pro Pro Cys Ile Lys Gly Trp Ile Pro Trp Ile Gly Val Gly Phe Glu
      30                  35                  40

 ttt ggg aaa gcc cct cta gaa ttt ata gag aaa gca aga atc aag tat      372
 Phe Gly Lys Ala Pro Leu Glu Phe Ile Glu Lys Ala Arg Ile Lys Tyr
  45                  50                  55                  60

 gga cca ata ttt aca gtc ttt gct atg gga aac cga atg acc ttt gtt      420
 Gly Pro Ile Phe Thr Val Phe Ala Met Gly Asn Arg Met Thr Phe Val
                  65                  70                  75

 act gaa gaa gaa gga att aat gtg ttt cta aaa tcc aaa aaa gta gat      468
 Thr Glu Glu Glu Gly Ile Asn Val Phe Leu Lys Ser Lys Lys Val Asp
              80                  85                  90

 ttt gaa cta gca gtg caa aat atc gtt tat cgt aca gca tca att cca      516
 Phe Glu Leu Ala Val Gln Asn Ile Val Tyr Arg Thr Ala Ser Ile Pro
          95                 100                 105

 aag aat gtc ttt tta gca ctg cat gaa aaa ctc tat att atg ttg aaa      564
 Lys Asn Val Phe Leu Ala Leu His Glu Lys Leu Tyr Ile Met Leu Lys
     110                 115                 120

 ggg aaa atg ggg act gtc aat ctc cat cag ttt act ggg caa ctg act      612
 Gly Lys Met Gly Thr Val Asn Leu His Gln Phe Thr Gly Gln Leu Thr
 125                 130                 135                 140

 gaa gaa tta cat gaa caa ctg gag aat tta ggc act cat ggg aca atg      660
 Glu Glu Leu His Glu Gln Leu Glu Asn Leu Gly Thr His Gly Thr Met
                 145                 150                 155

 gac ctg aac aac tta gta aga cat ctc ctt tat cca gtc aca gtg aat      708
 Asp Leu Asn Asn Leu Val Arg His Leu Leu Tyr Pro Val Thr Val Asn
             160                 165                 170

 atg ctc ttt aat aaa agt ttg ttt tcc aca aac aag aaa aaa atc aag      756
 Met Leu Phe Asn Lys Ser Leu Phe Ser Thr Asn Lys Lys Lys Ile Lys
         175                 180                 185

 gag ttc cat cag tat ttt caa gtt tat gat gaa gat ttt gag tat ggg      804
 Glu Phe His Gln Tyr Phe Gln Val Tyr Asp Glu Asp Phe Glu Tyr Gly
     190                 195                 200

 tcc cag ttg cca gag tgt ctt cta aga aac tgg tca aaa tcc aaa aag      852
 Ser Gln Leu Pro Glu Cys Leu Leu Arg Asn Trp Ser Lys Ser Lys Lys
 205                 210                 215                 220

 tgg ttc ctg gaa ctg ttt gag aaa aac att cca gat ata aaa gca tgt      900
 Trp Phe Leu Glu Leu Phe Glu Lys Asn Ile Pro Asp Ile Lys Ala Cys
                 225                 230                 235

 aaa tct gca aaa gat aat tcc atg aca tta ttg caa gct acg ctg gat      948
 Lys Ser Ala Lys Asp Asn Ser Met Thr Leu Leu Gln Ala Thr Leu Asp
             240                 245                 250

 att gta gag acg gaa aca agt aag gaa aac tca ccc aat tat ggg ctc      996
 Ile Val Glu Thr Glu Thr Ser Lys Glu Asn Ser Pro Asn Tyr Gly Leu
         255                 260                 265

 tta ctg ctt tgg gct tct ctg tct aat gct gtt cct gtt gca ttt tgg     1044
 Leu Leu Leu Trp Ala Ser Leu Ser Asn Ala Val Pro Val Ala Phe Trp
     270                 275                 280

 aca ctt gca tac gtc ctt tct cat cct gat atc cac aag gcc att atg     1092
 Thr Leu Ala Tyr Val Leu Ser His Pro Asp Ile His Lys Ala Ile Met
 285                 290                 295                 300

 gaa ggc ata tct tct gtg ttt ggc aaa gca ggc aaa gat aag att aaa     1140
 Glu Gly Ile Ser Ser Val Phe Gly Lys Ala Gly Lys Asp Lys Ile Lys
                 305                 310                 315

 gtg tct gag gat gac ctg gag aaa ctc ctt cta att aaa tgg tgt gtt     1188
 Val Ser Glu Asp Asp Leu Glu Lys Leu Leu Leu Ile Lys Trp Cys Val
             320                 325                 330

 ttg gaa acc att cgt tta aaa gct cct ggt gtc att act aga aaa gtg     1236
 Leu Glu Thr Ile Arg Leu Lys Ala Pro Gly Val Ile Thr Arg Lys Val
         335                 340                 345

 gtg aag cct gtg gaa att ttg aat tac atc att cct tct ggt gac ttg     1284
 Val Lys Pro Val Glu Ile Leu Asn Tyr Ile Ile Pro Ser Gly Asp Leu
     350                 355                 360

 ttg atg ttg tct cca ttt tgg ctg cat aga aat cca aag tat ttt cct     1332
 Leu Met Leu Ser Pro Phe Trp Leu His Arg Asn Pro Lys Tyr Phe Pro
 365                 370                 375                 380

 gag cct gaa ttg ttc aaa cct gaa cgt tgg aaa aag gca aat tta gag     1380
 Glu Pro Glu Leu Phe Lys Pro Glu Arg Trp Lys Lys Ala Asn Leu Glu
                 385                 390                 395

 aag cac tct ttc ttg gac tgc ttc atg gca ttt gga agc ggg aag ttc     1428
 Lys His Ser Phe Leu Asp Cys Phe Met Ala Phe Gly Ser Gly Lys Phe
             400                 405                 410

 cag tgt cct gca agg tgg ttt gct ctg tta gag gtt cag atg tgt att     1476
 Gln Cys Pro Ala Arg Trp Phe Ala Leu Leu Glu Val Gln Met Cys Ile
         415                 420                 425

 att tta ata ctt tat aaa tat gac tgt agt ctt ctg gac cca tta ccc     1524
 Ile Leu Ile Leu Tyr Lys Tyr Asp Cys Ser Leu Leu Asp Pro Leu Pro
     430                 435                 440

 aaa cag agt tat ctc cat ttg gtg ggt gtc ccc cag ccg gaa ggg caa     1572
 Lys Gln Ser Tyr Leu His Leu Val Gly Val Pro Gln Pro Glu Gly Gln
 445                 450                 455                 460

 tgc cga att gaa tat aaa caa aga ata tga c atctgttggg cctcacaagg     1623
 Cys Arg Ile Glu Tyr Lys Gln Arg Ile 
                 465

 accagggcct tctggaggag tggcactacc ccacctggca gcacctagac ctgagctcta   1683

 caaaaacaca ctgcttcact ttgttttagg acttagttca agaacacatt caaatggtgc   1743

 atgtgtttgg tatcttcaac agtagaccaa gaatctaaca tcactctcag taatatagag   1803

 accggaatac atggtttata ggaaatgatc aaatgatcca aaaaaactcc acatttttta   1863

 agaagttgga atttgatttc atgcataact gtattaaaac attaaataga aataatgtca   1923

 tttgaatgaa aatcttatca cattaaattc actgtgaagg cagcatactt aaaggaattt   1983

 gatttcatgc ataactgtat taaaacatta aatagaaata atgtcatttg aatgaaaatc   2043

 ttatcacatt aaattcactg tgaaggcagc atacttaaat ttttattttg aaaagtctaa   2103

 aaggcttaga tttttaaaat ttaataatta tttctacaaa ttttctattt ttcttgaggt   2163

 gattctcaac tagcaattgg aactcctagg ctctattaac ataattcttt attgtaaacg   2223

 tatctaatgc taaaagtaat aaaatggtag ttttctgaga cctgtgagga caggaatggt   2283

 gtcttacatt catttctaca ctttattatg ctcaggattg caccttcttt acagagtata   2343

 ttcaataaat gtatgttgat tgatgtattg atttatattt taattaacct ggaagcattg   2403

 ttttgactca aagtgtttgc aattatagtt tggcagatac catatttttg ctaatgcata   2463

 gaaacacaaa tatancggta tgccaagaca aaaaaaaaaa a                       2504




      <210> 202
      <211> 2325
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(1036)

      <400> 202
 gggatatggc tccggaattc ccgggtcgac gatttcgtgg cgagccgtga ag    atg      55
                                                              Met
                                                                1

 gcg gca gtg gtg gag gtg gag gtt gga ggt ggt gct gct ggg gaa cgg      103
 Ala Ala Val Val Glu Val Glu Val Gly Gly Gly Ala Ala Gly Glu Arg
               5                  10                  15

 gag ctg gat gag gtt gat atg tca gat ctc tct cca gaa gag caa tgg      151
 Glu Leu Asp Glu Val Asp Met Ser Asp Leu Ser Pro Glu Glu Gln Trp
          20                  25                  30

 agg gtc gag cac gca cgc atg cat gcc aag cac cgt ggc cat gaa gct      199
 Arg Val Glu His Ala Arg Met His Ala Lys His Arg Gly His Glu Ala
      35                  40                  45

 atg cat gct gaa atg gtc ctc atc ctc atc gca acc ttg gtg gtg gcc      247
 Met His Ala Glu Met Val Leu Ile Leu Ile Ala Thr Leu Val Val Ala
  50                  55                  60                  65

 cag ctg ctc ctg gtg cag tgg aag cag agg cac cca cgc tcc tac aat      295
 Gln Leu Leu Leu Val Gln Trp Lys Gln Arg His Pro Arg Ser Tyr Asn
                  70                  75                  80

 atg gtg acc ctc ttt cag atg tgg gtt gtt ccc ctc tat ttc aca gtg      343
 Met Val Thr Leu Phe Gln Met Trp Val Val Pro Leu Tyr Phe Thr Val
              85                  90                  95

 aag ctg cac tgg tgg agg ttc cta gtg atc tgg atc ttg ttc tct gct      391
 Lys Leu His Trp Trp Arg Phe Leu Val Ile Trp Ile Leu Phe Ser Ala
         100                 105                 110

 gtc aca gcc ttt gtt acc ttc cga gcc acc cga aaa cct cta gta cag      439
 Val Thr Ala Phe Val Thr Phe Arg Ala Thr Arg Lys Pro Leu Val Gln
     115                 120                 125

 aca acc cca agg ttg gtt tat aag tgg ttc ctg cta atc tat aaa atc      487
 Thr Thr Pro Arg Leu Val Tyr Lys Trp Phe Leu Leu Ile Tyr Lys Ile
 130                 135                 140                 145

 agc tat gcc act ggc att gtt ggc tac atg gct gtc atg ttt acc ctc      535
 Ser Tyr Ala Thr Gly Ile Val Gly Tyr Met Ala Val Met Phe Thr Leu
                 150                 155                 160

 ttt ggt ctt aac tta tta ttc aag atc aaa cca gaa gat gcc atg gac      583
 Phe Gly Leu Asn Leu Leu Phe Lys Ile Lys Pro Glu Asp Ala Met Asp
             165                 170                 175

 ttt ggc atc tcc ctt ctc ttc tat ggc ctc tac tat gga gtt ctg gaa      631
 Phe Gly Ile Ser Leu Leu Phe Tyr Gly Leu Tyr Tyr Gly Val Leu Glu
         180                 185                 190

 cgg gac ttt gca gaa atg tgt gca gac tac atg gca tct acc ata ggg      679
 Arg Asp Phe Ala Glu Met Cys Ala Asp Tyr Met Ala Ser Thr Ile Gly
     195                 200                 205

 ttc tac agc gag tcg ggc atg cct acc aaa cat ctt tca gac agt gtg      727
 Phe Tyr Ser Glu Ser Gly Met Pro Thr Lys His Leu Ser Asp Ser Val
 210                 215                 220                 225

 tgt gct gtg tgt ggg cag cag atc ttt gtg gac gtc agt gaa gag ggg      775
 Cys Ala Val Cys Gly Gln Gln Ile Phe Val Asp Val Ser Glu Glu Gly
                 230                 235                 240

 atc att gag aac acg tat agg ctg tcc tgc aat cat gtc ttc cac gag      823
 Ile Ile Glu Asn Thr Tyr Arg Leu Ser Cys Asn His Val Phe His Glu
             245                 250                 255

 ttc tgc atc cgt ggc tgg tgc atc gtg gga aag aag caa acg tgt ccc      871
 Phe Cys Ile Arg Gly Trp Cys Ile Val Gly Lys Lys Gln Thr Cys Pro
         260                 265                 270

 tac tgc aaa gag aag gta gac ctc aag agg atg ttc agc aat ccc tgg      919
 Tyr Cys Lys Glu Lys Val Asp Leu Lys Arg Met Phe Ser Asn Pro Trp
     275                 280                 285

 gag agg cct cac gtc atg tat ggg caa ctg ctg gac tgg ctt cga tac      967
 Glu Arg Pro His Val Met Tyr Gly Gln Leu Leu Asp Trp Leu Arg Tyr
 290                 295                 300                 305

 ttg gta gcc tgg cag cct gtc atc att ggt gta gtc caa ggc atc aac     1015
 Leu Val Ala Trp Gln Pro Val Ile Ile Gly Val Val Gln Gly Ile Asn
                 310                 315                 320

 tac atc ctg ggc ctg gaa tag tg atgaagagca tcagtggaaa acccacccca     1068
 Tyr Ile Leu Gly Leu Glu 
             325

 cacgccatgg acctcagggc actctcctcc ctgcccacaa agacctcctg ggtgggaaag   1128

 actcaaaggg gcgcttgggc cactcaggac ccctccggct gtgtcggact ggggagggat   1188

 atgatggaga gccagccagt ggggctgtca gcagtggggg gctttttaaa agaaaactat   1248

 tttgatgaat atatttaaaa aacctttttt tattgtggag cataggaatt gcccccctcc   1308

 aggcttcacc ctccctgcct aagcaggttg ggggcagagc catgacattt ttggtttaaa   1368

 ggagccttct catctctggc cgagaacact gctgggctcc caggtagctg aaggcctcag   1428

 cccacccact cccttcttcc ctgtgtgggg ctcaagcctg gtgcacttag tatagaagag   1488

 ctaacgtact caggcttgtg ccacgggtga gcactgaggc cccaggtgtc ctccctcccc   1548

 cactgtctgg gacacaggac aggtgttgcg tctgactctg tctccccctg tccaagagct   1608

 ataggctggt tgaggcaagt ggaaccttat cagtgacttg gccaacaagg gaagccttgg   1668

 ggcctcagaa ttcattgaaa atttgttttg ggacaactgg aagaatcagc accatggata   1728

 ctcgcccgtg ggcagggctg tggtcagcca agaatagagg tcatatagtt gggccatggg   1788

 gcaattgttg gcagccatga ctgacggccc cttgtgcaag ctcattcttc agtggatcct   1848

 tcagtggagt ggtgacacgt gccagcggtc actctgccac atcacttcct tcttgaaagc   1908

 ctaagagtgc gtatgcgtgt gtgtgtgtgt gtgtgtgtac gtgaggcaga agaatatgac   1968

 agatgtcagc ttctccctgt gtcagatgat atgtccttga agctggcagg ggattcccag   2028

 tccagggaat atccctacat gatttttgtc attcatgggt cctccctggg cctgacaacg   2088

 ggagtggtgg gtgggtgaga acaggttctg agagggggct tctaggaagg ccccagccct   2148

 agtcctaggc gacttgaata aagtgggagg tcaaacatgg gccttcggca ttgggtttct   2208

 agggaatatg gctcagtagg gcctgcccct tcaagggcag caagaacgaa gcaggatgtt   2268

 gtcactcccg tctgaataaa gctccatgag ctgggttgga aagctgaaaa aaaaaaa      2325




      <210> 203
      <211> 5845
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(3000)

      <400> 203
 taagcttgcg gccgcagcag ccctgtttga tctgtggatg aa   atg aat cat gat      54
                                                  Met Asn His Asp
                                                    1

 ttt caa gct ctt gca tta gaa tct cgg gga atg gga gag ctt ttg cct      102
 Phe Gln Ala Leu Ala Leu Glu Ser Arg Gly Met Gly Glu Leu Leu Pro
   5                  10                  15                  20

 acc aaa aag ttt tgg gaa cct gat gat tca aca aaa gat gga caa aaa      150
 Thr Lys Lys Phe Trp Glu Pro Asp Asp Ser Thr Lys Asp Gly Gln Lys
                  25                  30                  35

 ggc ata ttt ctt ggg gat gat gaa tgg aga gag act gca tgg gga gct      198
 Gly Ile Phe Leu Gly Asp Asp Glu Trp Arg Glu Thr Ala Trp Gly Ala
              40                  45                  50

 tct cac cat tca atg tcc cag cct att atg gta cag aga aga tct gga      246
 Ser His His Ser Met Ser Gln Pro Ile Met Val Gln Arg Arg Ser Gly
          55                  60                  65

 cag ggt ttt cat gga aac agt gaa gta aat gca ata ctg tct ccg cga      294
 Gln Gly Phe His Gly Asn Ser Glu Val Asn Ala Ile Leu Ser Pro Arg
      70                  75                  80

 tca gaa agt gga ggc ctt ggt gtg agc atg gta gaa tat gta tta agt      342
 Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu Tyr Val Leu Ser
  85                  90                  95                 100

 tct tct cct gct gat aaa ttg gat tct cga ttt agg aag gga aat ttt      390
 Ser Ser Pro Ala Asp Lys Leu Asp Ser Arg Phe Arg Lys Gly Asn Phe
                 105                 110                 115

 ggc act aga gat gct gaa aca gat gga cct gag aaa gga gat caa aaa      438
 Gly Thr Arg Asp Ala Glu Thr Asp Gly Pro Glu Lys Gly Asp Gln Lys
             120                 125                 130

 ggc aag gct tct cca ttt gag gag gac caa aac aga gat ctt aaa caa      486
 Gly Lys Ala Ser Pro Phe Glu Glu Asp Gln Asn Arg Asp Leu Lys Gln
         135                 140                 145

 gga gat gat gat gat tct aaa ata aat ggc aga ggt ttg cca aat gga      534
 Gly Asp Asp Asp Asp Ser Lys Ile Asn Gly Arg Gly Leu Pro Asn Gly
     150                 155                 160

 atg gat gcc gat tgc aaa gat ttt aat cgt act cct gga agt cgt caa      582
 Met Asp Ala Asp Cys Lys Asp Phe Asn Arg Thr Pro Gly Ser Arg Gln
 165                 170                 175                 180

 gcc tct cca act gaa gta gtt gag cgc ttg ggc ccc aat act aat ccc      630
 Ala Ser Pro Thr Glu Val Val Glu Arg Leu Gly Pro Asn Thr Asn Pro
                 185                 190                 195

 tca gaa gga ctg ggg cct ctt cct aat cct aca gct aat aaa cca ctt      678
 Ser Glu Gly Leu Gly Pro Leu Pro Asn Pro Thr Ala Asn Lys Pro Leu
             200                 205                 210

 gtt gaa gaa ttt tca aat cct gaa act cag aat ctg gat gcc atg gaa      726
 Val Glu Glu Phe Ser Asn Pro Glu Thr Gln Asn Leu Asp Ala Met Glu
         215                 220                 225

 caa gtt ggt ctg gaa tcc tta cag ttt gac tat cct ggt aat cag gta      774
 Gln Val Gly Leu Glu Ser Leu Gln Phe Asp Tyr Pro Gly Asn Gln Val
     230                 235                 240

 cca atg gac tct tca gga gct act gta ggc ctt ttt gac tac aat tcc      822
 Pro Met Asp Ser Ser Gly Ala Thr Val Gly Leu Phe Asp Tyr Asn Ser
 245                 250                 255                 260

 cag cag cag ctc ttt cag agg act aat gca cta aca gtt caa cag tta      870
 Gln Gln Gln Leu Phe Gln Arg Thr Asn Ala Leu Thr Val Gln Gln Leu
                 265                 270                 275

 act gca gct caa cag cag caa tat gca tta gca gca gct cag cag cca      918
 Thr Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala Ala Gln Gln Pro
             280                 285                 290

 cat ata gct ggt gta ttc tca gca ggc ctt gct cca gct gca ttt gtg      966
 His Ile Ala Gly Val Phe Ser Ala Gly Leu Ala Pro Ala Ala Phe Val
         295                 300                 305

 cca aat cca tac att att agt gct gct cct cca ggg acc gat ccg tat     1014
 Pro Asn Pro Tyr Ile Ile Ser Ala Ala Pro Pro Gly Thr Asp Pro Tyr
     310                 315                 320

 act gca gca gga ttg gct gca gca gct aca tta gca ggt cca gca gtg     1062
 Thr Ala Ala Gly Leu Ala Ala Ala Ala Thr Leu Ala Gly Pro Ala Val
 325                 330                 335                 340

 gtt cca cct cag tat tac ggc gtt cca tgg ggg gtg tat cca gcc aac     1110
 Val Pro Pro Gln Tyr Tyr Gly Val Pro Trp Gly Val Tyr Pro Ala Asn
                 345                 350                 355

 tta ttt cag cag caa gct gca gct gcg gca aat aac aca gcc agt cag     1158
 Leu Phe Gln Gln Gln Ala Ala Ala Ala Ala Asn Asn Thr Ala Ser Gln
             360                 365                 370

 caa gca gca tca caa gct cag cct gga cag caa cag gtt ctc cgt gct     1206
 Gln Ala Ala Ser Gln Ala Gln Pro Gly Gln Gln Gln Val Leu Arg Ala
         375                 380                 385

 gga gca ggt cag cgt cct ctt act ccc aat cag ggt cag caa ggg cag     1254
 Gly Ala Gly Gln Arg Pro Leu Thr Pro Asn Gln Gly Gln Gln Gly Gln
     390                 395                 400

 caa gca gaa tca ctt gcg gca gct gca gca gca aat cca aca ttg gct     1302
 Gln Ala Glu Ser Leu Ala Ala Ala Ala Ala Ala Asn Pro Thr Leu Ala
 405                 410                 415                 420

 ttt ggt cag ggt ctt gct act ggc atg cca ggc tat caa gta cta gct     1350
 Phe Gly Gln Gly Leu Ala Thr Gly Met Pro Gly Tyr Gln Val Leu Ala
                 425                 430                 435

 cca act gcc tat tat gat cag act ggt gcc tta gtg gtt ggc cct gga     1398
 Pro Thr Ala Tyr Tyr Asp Gln Thr Gly Ala Leu Val Val Gly Pro Gly
             440                 445                 450

 gca agg act ggc ctt gga gct cca gtt cgg tta atg gct cca aca cct     1446
 Ala Arg Thr Gly Leu Gly Ala Pro Val Arg Leu Met Ala Pro Thr Pro
         455                 460                 465

 gtt tta att agt tca gca gca gca caa gct gca gca gca gca gca gct     1494
 Val Leu Ile Ser Ser Ala Ala Ala Gln Ala Ala Ala Ala Ala Ala Ala
     470                 475                 480

 gga gga act gca agt agc ctt aca ggc agc aca aat ggt ctg ttt cgg     1542
 Gly Gly Thr Ala Ser Ser Leu Thr Gly Ser Thr Asn Gly Leu Phe Arg
 485                 490                 495                 500

 cca att ggc act cag cca cca cag cag cag caa cag cag cca agc act     1590
 Pro Ile Gly Thr Gln Pro Pro Gln Gln Gln Gln Gln Gln Pro Ser Thr
                 505                 510                 515

 aat ctg caa tct aat tca ttt tat gga agc agt tct ttg act aat agc     1638
 Asn Leu Gln Ser Asn Ser Phe Tyr Gly Ser Ser Ser Leu Thr Asn Ser
             520                 525                 530

 tcc cag agt agt tct tta ttt tct cat gga cct ggt caa cct gga agt     1686
 Ser Gln Ser Ser Ser Leu Phe Ser His Gly Pro Gly Gln Pro Gly Ser
         535                 540                 545

 aca tct ctt ggc ttt gga agt ggt aac tct ttg ggt gct gct ata ggc     1734
 Thr Ser Leu Gly Phe Gly Ser Gly Asn Ser Leu Gly Ala Ala Ile Gly
     550                 555                 560

 tca gcc ctc agt gga ttt ggt tca tca gga gga ctg aca aat ggt agt     1782
 Ser Ala Leu Ser Gly Phe Gly Ser Ser Gly Gly Leu Thr Asn Gly Ser
 565                 570                 575                 580

 ggt cga tat atc tct gca gca cct gga gca gaa gca aaa tat cga agt     1830
 Gly Arg Tyr Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys Tyr Arg Ser
                 585                 590                 595

 gct tca agc act tcc agt cta ttt agc tcc agc agc cag ctc ttt cct     1878
 Ala Ser Ser Thr Ser Ser Leu Phe Ser Ser Ser Ser Gln Leu Phe Pro
             600                 605                 610

 cct tcc cgg ctt cgg tat aat agg tct gat att atg cct tct ggc cgc     1926
 Pro Ser Arg Leu Arg Tyr Asn Arg Ser Asp Ile Met Pro Ser Gly Arg
         615                 620                 625

 agt aga tta ttg gaa gat ttc aga aac aac cgc ttc cca aac ctt cag     1974
 Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Phe Pro Asn Leu Gln
     630                 635                 640

 ctt aga gac ttg att gga cat ata gtt gag ttt tct caa gac cag cat     2022
 Leu Arg Asp Leu Ile Gly His Ile Val Glu Phe Ser Gln Asp Gln His
 645                 650                 655                 660

 ggt tct aga ttc ata cag caa aaa cta gag aga gct act cca gct gag     2070
 Gly Ser Arg Phe Ile Gln Gln Lys Leu Glu Arg Ala Thr Pro Ala Glu
                 665                 670                 675

 cga cag atg gta ttt aat gaa att ctg caa gca gcc tat caa tta atg     2118
 Arg Gln Met Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met
             680                 685                 690

 act gat gtt ttt ggc aac tat gtt ata cag aag ttt ttt gag ttt ggg     2166
 Thr Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly
         695                 700                 705

 agt ctg gat caa aaa tta gcc ctg gct act cgt att cgt ggt cat gtt     2214
 Ser Leu Asp Gln Lys Leu Ala Leu Ala Thr Arg Ile Arg Gly His Val
     710                 715                 720

 cta ccc tta gcc ttg cag atg tat ggc tgc cgc gtt att cag aaa gca     2262
 Leu Pro Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala
 725                 730                 735                 740

 tta gaa tct att tct tct gac cag cag agt gaa atg gta aag gag ctg     2310
 Leu Glu Ser Ile Ser Ser Asp Gln Gln Ser Glu Met Val Lys Glu Leu
                 745                 750                 755

 gat ggt cat gtg ctc aaa tgt gtg aaa gat cag aat gga aac cat gtt     2358
 Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val
             760                 765                 770

 gta caa aaa tgt atc gaa tgt gtt cag cca cag tca cta cag ttc atc     2406
 Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile
         775                 780                 785

 att gat gct ttc aag gga caa gta ttt gtg ctt tca act cat cct tat     2454
 Ile Asp Ala Phe Lys Gly Gln Val Phe Val Leu Ser Thr His Pro Tyr
     790                 795                 800

 ggc tgc aga gta att cag cgc atc cta gag cat tgc act gca gaa cag     2502
 Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys Thr Ala Glu Gln
 805                 810                 815                 820

 acc tta cct atc tta gaa gaa ctc cac caa cat aca gag cag ttg gta     2550
 Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr Glu Gln Leu Val
                 825                 830                 835

 cag gat cag tat ggc aat tat gtt att cag cat gta ctg gaa cac ggt     2598
 Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val Leu Glu His Gly
             840                 845                 850

 cga cct gaa gac aag agc aaa att gtt tcc gaa atc agg gga aag gtt     2646
 Arg Pro Glu Asp Lys Ser Lys Ile Val Ser Glu Ile Arg Gly Lys Val
         855                 860                 865

 tta gcc ctg agt caa cac aaa ttt gcc agc aat gta gta gaa aag tgt     2694
 Leu Ala Leu Ser Gln His Lys Phe Ala Ser Asn Val Val Glu Lys Cys
     870                 875                 880

 gtt act cat gcc tcc cgt gct gag aga gct tta ctg att gac gag gtt     2742
 Val Thr His Ala Ser Arg Ala Glu Arg Ala Leu Leu Ile Asp Glu Val
 885                 890                 895                 900

 tgc tgc cag aat gat ggt cct cac agt gcc tta tac acc atg atg aag     2790
 Cys Cys Gln Asn Asp Gly Pro His Ser Ala Leu Tyr Thr Met Met Lys
                 905                 910                 915

 gcc cag tat gcc aat tac gtg gtt caa aag atg att gat atg gct gaa     2838
 Ala Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile Asp Met Ala Glu
             920                 925                 930

 cct gct cag aga aag ata atc atg cac aag att cga cct cac att act     2886
 Pro Ala Gln Arg Lys Ile Ile Met His Lys Ile Arg Pro His Ile Thr
         935                 940                 945

 act ttg cgc aaa tac aca tac ggg aag cat ata ctg gcc aag ttg gaa     2934
 Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu Ala Lys Leu Glu
     950                 955                 960

 aag tat tat ttg aag aat agc ccg gac cta gga cct att gga gga cca     2982
 Lys Tyr Tyr Leu Lys Asn Ser Pro Asp Leu Gly Pro Ile Gly Gly Pro
 965                 970                 975                 980

 cca aat gga atg ctg taa attaca ggagcaagag aaagaagata atttaaccat     3036
 Pro Asn Gly Met Leu 
                 985

 gtgaaaagaa tttttttgtg cgtgaattat caaaacacaa ctcaactatg aatcttcaat   3096

 ttttttttaa agcaaaacta tttattgact ttattcatcc atttgtaaat tttttaaggt   3156

 tcttgtgtat atttgggggg tgggggatga attataaatt atattcagcc ctgagtggag   3216

 acctatcaga ttggattgct ggcaaagcac agaatgcctg tatatgatgt aactgtatca   3276

 aaaataaaaa gctgtcacat attttgtaaa tttttacctt gtaaagtcac aaaaatagtt   3336

 tttaaaggaa aaagtacagt attcttttaa taaactggct cacagtctgg taggtctaca   3396

 accccatagc acaacaggtt tatagagatg tatatagaat tatagtcctt atttttttcc   3456

 tttgcgtgaa accttttata acagattaac aatcaactgc ataaatatta ttaatatttt   3516

 aaaaagagtt aagttgtatt ttgataattc acaaactatc atgcaaataa cgagtaagta   3576

 gacaagaata aagtggtttg agatgaaaag aacctaacat tatttacagt agatgtggtt   3636

 ttaatacaat tactgcccta aaatgtctct ggcaatgtac agaaatattg tatatactta   3696

 catatgtaat tgttgtaaga gttaaataca aaatcatggt gacacttcca attaagtgca   3756

 ctaaatgaaa agttaagtca cttattaact tttcagtttg gtttgcaatg agaaagagtg   3816

 gaaatttgta ttttgttttg cttatagaat tacagacatg ttgaggaagt gttgagcttt   3876

 attttgcttt ttcatagagg cagaaagtag gaaccagata gagatgaaaa ggggccactg   3936

 aaaagtgaat ttgatagctc agcatttaag catgattaca tattcagata gctctttttg   3996

 ctttctataa atatatgcat tgtgtgtgta gtaatagatg taagtttaca ctttgaaagg   4056

 aaatcttgtt tcaatgttta ttataaaagc cttgctaatt tagtagtgat gctttccttg   4116

 gttgtacagg tgtacatttg taaaccttca tgctgtaaat ggaatttgtt ttatctcttt   4176

 gggatacatt tgcattttag tgtacattta cgtccctgcc ctctttgacc tggcaatata   4236

 gtgttgtata atgtaaattt atttctccaa atcgagagtg attttttaaa aattttttat   4296

 ctttatatgg tttcagaagt atgaaccagc tttcttttta ttattgtgag atcattttgt   4356

 tttataacat agttgttgac tgttaatatg gacctgctag aatttggatc actttcaatt   4416

 gaagtcaggg tattgtgcat aatagaaagt attggactga gatatttggt taccatggag   4476

 gccaatgctt ttttcatctt attaaatgtg atgtgacttt tttctttgta cagaagagta   4536

 ctgtattttt gaatagccta ctcccaagta agagcaaatc tgtatgataa cattttttcc   4596

 tctggacata agacataaca gtaacacgat gtacatttac aagcggcctt atgtacattt   4656

 cccaacaatc tttttaaggc aaaattgtga ccatatgtgt ataattaaaa tcgtttttaa   4716

 tcctttgcct atgaaaatat tttggaaaaa aacttgctgt gtatattcag tttctgaaag   4776

 ataaagaaag tgctttgtat tttgttgaag tcagtatttt gtataaacat ttatgttgac   4836

 ccacttatgt tcagtgctga aaactaaaat gaacatgcta ttctgtcagc tgaatatgga   4896

 agagatcttt ttttactaga gatctgcaga agaaacgcaa tcttctgagc acaatatgga   4956

 atctaaaggt tttatcactt agttgttcat attatgaacc taaaaataat ggcataaagt   5016

 ttggggatgc caggcatact ttttcatgtt tggtgttgag ttattttact tttctaaccc   5076

 aacattcctt ggtgagacca ttaaatccaa acacttgtca ccgttccttc tcatagtcac   5136

 tctgggtcat cagcatgtcc cagtcactgc agcaacgcct tgtgtttgtt tcattttttt   5196

 aaaacccaca caaagccgct gtctcacttt ttcctacttt accaacctca gagtatttcg   5256

 gcccgtatcg aacttttgtt ctcagtatca gcccatggtt tcaggatcaa agctgtcatg   5316

 ttggagattg gtaatggctt tcctgtcttt gtacagttga attcctagtc ttccttcatc   5376

 cttgccctct gttggcacag gcattatctc tgcaatttta gaaaatgaca agtagagaat   5436

 actacattga gaaactaaac cctcttcttg gggtcctgat actcattccc atttgtccca   5496

 gtgctgacaa cccaatcttc ccaatacttt caggcctgct ctacaaaagt acctgttctt   5556

 gtagaaattt tacagtctgc cattttgggt gcccacccca atttttacct tttagtaagt   5616

 tggcatgaaa ttttggtaaa atctgaaaat cacatttcag aataaaacaa ttgggcaaaa   5676

 ctacctaggc tttactcttg agtgtctcct tttgataggg attgtttctg gaccagtttg   5736

 tctaagtcct ggctcttatt ggttcatatg aaataatgtt aacttcactt ctttgtatat   5796

 tatgtataaa ttagaaaatg aaaaatgtgt gaataacatt gtatgaaat               5845




      <210> 204
      <211> 6581
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (446)..(1423)

      <400> 204
 gaattcttgg gtcgacgatt tcgtcttcgg ttggtgtgtg tcgaagaaac ctgactgcgc     60

 cctgaggaga acagcggaga aggtccaccg agcctggcga aaggtccgct gagcgggctg    120

 tcgtccggag ccactccggg ctgcggagca cccagtggag accgcgcctg gctcaggtgt    180

 gggaccccat ccttcctgtc ttcgcagagg agtcctcgcg tgaaataagc gggttttgaa    240

 aacaaaaaaa agaaggagtg gaagaggggg ccaggatcca ggcctccatc cccacagaag    300

 tgaagctaca gctgggaggt ctcctcccac cccaaccgtc accctgggtc ccgactgccc    360

 acctcctcct cctccccctc cccccaacaa caacaacaac aacaactcca agcacaccgg    420

 ccataagagt gcgtgtgtcc ccaac  atg acc gaa cga aga agg gac gag ctc     472
                              Met Thr Glu Arg Arg Arg Asp Glu Leu
                                1               5

 tct gaa gag atc aac aac tta aga gag aag gtc atg aag cag tcg gag      520
 Ser Glu Glu Ile Asn Asn Leu Arg Glu Lys Val Met Lys Gln Ser Glu
  10                  15                  20                  25

 gag aac aac aac ctg cag agc cag gtg cag aag ctc aca gag gag aac      568
 Glu Asn Asn Asn Leu Gln Ser Gln Val Gln Lys Leu Thr Glu Glu Asn
                  30                  35                  40

 acc acc ctt cga gag caa gtg gaa ccc acc cct gag gat gag gat gat      616
 Thr Thr Leu Arg Glu Gln Val Glu Pro Thr Pro Glu Asp Glu Asp Asp
              45                  50                  55

 gac atc gag ctc cgc ggt gct gca gca gct gct gcc cca ccc cct cca      664
 Asp Ile Glu Leu Arg Gly Ala Ala Ala Ala Ala Ala Pro Pro Pro Pro
          60                  65                  70

 ata gag gaa gag tgc cca gaa gac ctc cca gag aag ttc gat ggc aac      712
 Ile Glu Glu Glu Cys Pro Glu Asp Leu Pro Glu Lys Phe Asp Gly Asn
      75                  80                  85

 cca gac atg ctg gct cct ttc atg gcc cag tgc cag atc ttc atg gaa      760
 Pro Asp Met Leu Ala Pro Phe Met Ala Gln Cys Gln Ile Phe Met Glu
  90                  95                 100                 105

 aag agc acc agg gat ttc tca gtt gat cgt gtc cgt gtc tgc ttc gtg      808
 Lys Ser Thr Arg Asp Phe Ser Val Asp Arg Val Arg Val Cys Phe Val
                 110                 115                 120

 aca agc atg atg acc ggc cgt gct gcc cgt tgg gcc tca gca aag ctg      856
 Thr Ser Met Met Thr Gly Arg Ala Ala Arg Trp Ala Ser Ala Lys Leu
             125                 130                 135

 gag cgc tcc cac tac ctg atg cac aac tac cca gct ttc atg atg gaa      904
 Glu Arg Ser His Tyr Leu Met His Asn Tyr Pro Ala Phe Met Met Glu
         140                 145                 150

 atg aag cat gtc ttt gaa gac cct cag agg cga gag gtt gcc aaa cgc      952
 Met Lys His Val Phe Glu Asp Pro Gln Arg Arg Glu Val Ala Lys Arg
     155                 160                 165

 aag atc aga cgc ctg cgc caa ggc atg ggg tct gtc atc gac tac tcc     1000
 Lys Ile Arg Arg Leu Arg Gln Gly Met Gly Ser Val Ile Asp Tyr Ser
 170                 175                 180                 185

 aat gct ttc cag atg att gcc cag gac ctg gat tgg aac gag cct gcg     1048
 Asn Ala Phe Gln Met Ile Ala Gln Asp Leu Asp Trp Asn Glu Pro Ala
                 190                 195                 200

 ctg att gac cag tac cac gag ggc ctc agc gac cac att cag gag gag     1096
 Leu Ile Asp Gln Tyr His Glu Gly Leu Ser Asp His Ile Gln Glu Glu
             205                 210                 215

 ctc tcc cac ctc gag gtc gcc aag tcg ctg tct gct ctg att ggg cag     1144
 Leu Ser His Leu Glu Val Ala Lys Ser Leu Ser Ala Leu Ile Gly Gln
         220                 225                 230

 tgc att cac att gag aga agg ctg gcc agg gct gct gca gct cgc aag     1192
 Cys Ile His Ile Glu Arg Arg Leu Ala Arg Ala Ala Ala Ala Arg Lys
     235                 240                 245

 cca cgc tcg cca ccc cgg gcg ctg gtg ttg cct cac att gca agc cac     1240
 Pro Arg Ser Pro Pro Arg Ala Leu Val Leu Pro His Ile Ala Ser His
 250                 255                 260                 265

 cac cag gta gat cca acc gag ccg gtg gga ggt gcc cgc atg cgc ctg     1288
 His Gln Val Asp Pro Thr Glu Pro Val Gly Gly Ala Arg Met Arg Leu
                 270                 275                 280

 acg cag gaa gaa aaa gaa aga cgc aga aag ctg aac ctg tgc ctc tac     1336
 Thr Gln Glu Glu Lys Glu Arg Arg Arg Lys Leu Asn Leu Cys Leu Tyr
             285                 290                 295

 tgt gga aca gga ggt cac tac gct gac aat tgt cct gcc aag gcc tca     1384
 Cys Gly Thr Gly Gly His Tyr Ala Asp Asn Cys Pro Ala Lys Ala Ser
         300                 305                 310

 aag tct tcg ccg gcg gga aac tcc ccg gcc ccg ctg tag agggaccttc      1433
 Lys Ser Ser Pro Ala Gly Asn Ser Pro Ala Pro Leu 
     315                 320                 325

 agcgaccggg ccagaaataa taaggtcccc acaagatgat gcctcatctc cacacttgca   1493

 agtgatgctc cagattcatc ttccgggcag acacaccctg ttcgtccgag ccatgatcga   1553

 ttctggtgct tctggcaact tcattgatca cgaatatgtt gctcaaaatg gaattcctct   1613

 aagaatcaag gactggccaa tacttgtgga agcaattgat gggcgcccca tagcatcggg   1673

 cccagttgtc cacgaaactc acgacctgat agttgacctg ggagatcacc gagaggtgct   1733

 gtcatttgat gtgactcagt ctccattctt ccctgtcgtc ctaggggttc gctggctgag   1793

 cacacatgat cccaatatca catggagcac tcgatctatc gtctttgatt ctgaatactg   1853

 ccgctaccac tgccggatgt attctccaat accaccatcg ctcccaccac cagcaccaca   1913

 accgccactc tattatccag tagatggata cagagtttac caaccagtga ggtattacta   1973

 tgtccagaat gtgtacactc cagtagatga gcacgtctac ccagatcacc gcctggttga   2033

 ccctcacata gaaatgatac ctggagcaca cagtattccc agtggacatg tgtattcact   2093

 gtccgaacct gaaatggcag ctcttcgaga ttttgtggca agaaatgtaa aagatgggct   2153

 aattactcca acgattgcac ctaatggagc ccaagttctc caggtgaaga gggggtggaa   2213

 actgcaagtt tcttatgatt gccgagctcc aaacaatttt actatccaga atcagtatcc   2273

 tcgcctatct attccaaatt tagaagacca agcacacctg gcaacgtaca ctgaattcgt   2333

 acctcaaata cctggatacc aaacataccc cacatatgcc gcgtacccga cctacccagt   2393

 aggattcgcc tggtacccag tgggacgaga cggacaagga agatcactat atgtacctgt   2453

 gatgatcact tggaatccac actggtaccg ccagcctccg gtaccacagt acccgccgcc   2513

 acagccgccg cctccaccac caccaccgcc gccgcctcca tcttacagta ccctgtaaat   2573

 acctgtcatg tccttcagga tctctgccct caaaatttat tcctgttcag cttctcaatc   2633

 agtgactgtg tgctaaattt taggctactg tatcttcagg ccacctgagg cacatcctct   2693

 ctgaaacggc tatggaaggt tagggccact ctggactggc acacatccta aagcaccaaa   2753

 agaccttcaa cattttctga gagcaacaga gtatttgcca ataaatgatc tctcattttt   2813

 ccaccttgac tgccaatcta actaaaataa ttaataagtt tactttccag ccagtcctgg   2873

 aagtctgggt tttacctgcc aaaacctcca tcaccatcta aattataggc tgccaaattt   2933

 gctgtttaac atttacagag aagctgatac aaacgcagga aatgctgatt tctttatgga   2993

 gggggagacg aggaggagga ggacatgact tttcttgcgg tttcggtacc ctctttttaa   3053

 atcactggag gactgaggcc ttattaagga agccaaaatt atcggtgcag tgtggaaagg   3113

 cttccgtgat cctctcgctg cacccttaga aacttcaccg tcttcaaact ccatttccat   3173

 ggttctgtta attctcaagg agcagcaact cgactggttc tcccaggagc aggaaaaacc   3233

 cttgtgacat gaaacatctc aggcctgaaa agaaagtgct ctctcagatg gactcttgca   3293

 tgttaagact atgtcttcac atcatggtgc aaatcacatg tacccaatga ctccggcttt   3353

 gacacaacac cttaccatca tcatgccatg atggcttcca caaagcatta aacctggtaa   3413

 ccagagatta ctggtggctc cagcgttgtt agatgttcat gaaatgtgac cacctctcaa   3473

 tcacctttga gggctaaaga gtagcacatc aaaaggactc caaaatccca tacccaactc   3533

 ttaagagatt tgtcctggta cttcagaaag aattttcatg agtgttctta attggctgga   3593

 aaagcaccag ctgacgtttt ggaagaatct atccatgtgt ctgcctccat atgcatctgg   3653

 gcatttcatc ttcagtcccc tcattagact gtagcattag gatgtgtgga gagaggagaa   3713

 atgatttagc acccagattc acactcctat gcctggaagg gggacatctt tgaagaagag   3773

 gaattagggc tgtggacact gtcttgagga tgtggacttc cttagtgagc tccacattac   3833

 ttgatggtaa ccacttcaaa aggatcagaa tccacgtaat gaaaaaggtc cctctagagg   3893

 atggagctga tgtgaagctg ccaatggatg aaaagcctca gaaagcaact caaaggactc   3953

 aaagcaacgg acaacacaag agttgtcttc agcccagtga cacctctgat gtcccctgga   4013

 agctttgtgc taacctggga ctgcctgact tcctttagcc tggtcccttg ctactacctt   4073

 gaactgtttt atctaacctc tctttttctg tttaattctt tgctactgcc attgaccctg   4133

 ctgcaggatt tgtgtcattt tcctgcctgg ttgctgagac tccattttgc tgccacacac   4193

 agagatgtaa gaggcaggct ttaattgcca aagcacagtt tgagcagtag aaaacaacat   4253

 ggtgtatatc tcaaattgcc tgacatgaag aggagtctaa cggtgaagtt tcacttttca   4313

 tcagcatcat ctttcacatg ttcattatca tccgctctta ttcttgcatg tttaaacact   4373

 taaaattttt agtataattt ttagtgtgtt ttgaagtggt gactaggctt tcaaaaactt   4433

 ccattgaatt acaaagcact atccagttct tattgttaaa ctaagtaaaa atgataagta   4493

 acatagtgta aaatattcct ttactgtgaa cttcttacaa tgctgtgaat gagaggctcc   4553

 tcagaactgg agcatttgta taataattca tcctgttcat cttcaatttt aacatcatat   4613

 ataatttcaa ttctatcaat tgggccttta aaaatcatat aaaaggatat aaaatttgaa   4673

 aagagaaacc taattggcta tttaatccaa aacaactttt ttttttcctt caatggaatc   4733

 agaaagcttg tcaatcactc atgtgtttta gagtaattac ttttaaaatg gtgcatttgt   4793

 gcttctgaac tattttgaag agtcacttct gtttacctca agtatcaatt catcctccat   4853

 acatttgaat tcaagttgtt ttttgtcaaa tttacagttg tcaattgatc ttcaagctgc   4913

 agggtgccta gaaatgggcc gttgtctgta gccctggcat gtgcacacgg acatttgcca   4973

 ccactgcaag caaaagtctg gagaagttca ccaacgacaa gaacgattag ggaaaatatg   5033

 ctgctgtggg ttaacaactc agaaagtccc tgatccacat ttggctgttt actaaagctt   5093

 gtgattaact ttttggcagt gtgtactatg ctctattgct atatatgcta tctataaatg   5153

 tagatgttaa ggataagtaa ttctaaattt attattctat agttttgaag tttggttaag   5213

 tttcctttca ctcaattgat ttattttgtt gttaatcaaa tttatgttaa ttggatcctt   5273

 taaatttttt ttggcatttt ccaacaaaaa tggctttatt cataagaaag gaaaaaaatc   5333

 aatggaattt gatatctaaa gaagttagaa agggagcaaa ataaaaaaca taaaggagat   5393

 agatgaatta gtaagcaaat cagtagtcga gtttttcaaa ctggcaaaat taattaattg   5453

 acttttagcc caaatttaca ttgttaatta aatcaagaag gaagaagatc taagagctcc   5513

 cattgatagg caagcctaga gagaactagc taaatttatc atgctaggat attgaaacac   5573

 agaaagttta catacattta tgaagggtca atttagtttg gacagtgagg tatttgtctt   5633

 agtggaaaaa aggagaatta gtctgatcaa atcgtgaagt aatacagtga acttgcaggt   5693

 gcacaaaata agagggccac atctatatgg tgcagtctgg aattctgttt aagtttgtag   5753

 gtacctcttg gacttctgaa ttgatccagt tgtcatccac cacagacatc tcacatcaga   5813

 tacagacagt tccaagattg acaacagaga acaacctgct ggaaagacct gggcagaaat   5873

 ggagagccct gcgggaacca tgctacattt tcatctaaag agagaatgca catctgatga   5933

 gactgaaagt tctttgttgt tttagattgt agaatggtat tgaattggtc tgtggaaaat   5993

 tgcattgctt ttatttcttt gtgtaatcaa gtttaagtaa taggggatat ataatcataa   6053

 gcattttagg gtgggaggga ctattaagta attttaagtg ggtggggtta tttagaatgt   6113

 tagaataata ttatgtatta gatatcgcta taagtggaca tgcgtactta cttgtaaccc   6173

 tttaccctat aattgctatc cttaaagatt tcaaataaac tcggagggaa ctgcagggag   6233

 accaacttat ttagagcgaa ttggacatgg ataaaaaccc cagtgggaga aagttcaaag   6293

 gtgattagat taataattta atagaggatg agtgacctct gataaattac tgctagaatg   6353

 aacttgtcaa tgatggatgg taaattttca tggaagttat aaaagtgata aataaaaacc   6413

 cttgctttta cccctgtcag tagccctcct cctaccactg aaccccattg cccctacccc   6473

 tccttctaac tttattgctg tattctcttc actctatatt tctctctatt tgctaatatt   6533

 gcattgctgt tacaataaaa attcaataaa gatttagtgg ttaagtgc                6581




      <210> 205
      <211> 995
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(945)

      <400> 205
 ggcaccggtc cggaattccc gggtcgactt cgctgtcgac gatttcgtgg tcgacccacg     60

 cgtccgaaaa gcgagtggga tatcccaatc tttggactgc atcctggttg cctctactgt    120

 ggtcaccttt gggaagaa  atg tct tct gta aaa aga agt ctg aag caa gaa     171
                      Met Ser Ser Val Lys Arg Ser Leu Lys Gln Glu
                        1               5                  10

 ata gtt act cag ttt cac tgt tca gct gct gaa gga gat att gcc aag      219
 Ile Val Thr Gln Phe His Cys Ser Ala Ala Glu Gly Asp Ile Ala Lys
              15                  20                  25

 tta aca gga ata ctc agt cat tct cca tct ctt ctc aat gaa act tct      267
 Leu Thr Gly Ile Leu Ser His Ser Pro Ser Leu Leu Asn Glu Thr Ser
          30                  35                  40

 gaa aat ggc tgg act gct tta atg tat gcg gca agg aat ggg cac cca      315
 Glu Asn Gly Trp Thr Ala Leu Met Tyr Ala Ala Arg Asn Gly His Pro
      45                  50                  55

 gag ata gtc caa ttt ctg ctt gag aaa ggg tgt gac aga tca att gtc      363
 Glu Ile Val Gln Phe Leu Leu Glu Lys Gly Cys Asp Arg Ser Ile Val
  60                  65                  70                  75

 aat aaa tca agg cag act gca ctg gac att gct ata ttt tgg ggt tat      411
 Asn Lys Ser Arg Gln Thr Ala Leu Asp Ile Ala Ile Phe Trp Gly Tyr
                  80                  85                  90

 aag cat ata gct aat tta cta gct act gct aaa ggt ggg aag aag cct      459
 Lys His Ile Ala Asn Leu Leu Ala Thr Ala Lys Gly Gly Lys Lys Pro
              95                 100                 105

 tgg ttc cta acg aat gaa gtg gaa gaa tgt gaa aat tat ttt agc aaa      507
 Trp Phe Leu Thr Asn Glu Val Glu Glu Cys Glu Asn Tyr Phe Ser Lys
         110                 115                 120

 aca cta ctg gac cgg aaa agt gaa aag aga aat aat tct gac tgg ctg      555
 Thr Leu Leu Asp Arg Lys Ser Glu Lys Arg Asn Asn Ser Asp Trp Leu
     125                 130                 135

 cta gct aaa gaa agc cat cca gcc aca gtt ttt att ctt ttc tca gat      603
 Leu Ala Lys Glu Ser His Pro Ala Thr Val Phe Ile Leu Phe Ser Asp
 140                 145                 150                 155

 tta aat ccc ttg gtt act cta ggt ggc aat aaa gaa agt ttc caa cag      651
 Leu Asn Pro Leu Val Thr Leu Gly Gly Asn Lys Glu Ser Phe Gln Gln
                 160                 165                 170

 cca gaa gtt agg ctt tgt cag ctg aac tac aca gat ata aag gat tat      699
 Pro Glu Val Arg Leu Cys Gln Leu Asn Tyr Thr Asp Ile Lys Asp Tyr
             175                 180                 185

 ttg gcc cag cct gag aag atc acc ttg att ttt ctt gga gta gaa ctt      747
 Leu Ala Gln Pro Glu Lys Ile Thr Leu Ile Phe Leu Gly Val Glu Leu
         190                 195                 200

 gaa ata aaa gac aaa cta ctt aat tat gct ggt gaa gtc ccg aga gag      795
 Glu Ile Lys Asp Lys Leu Leu Asn Tyr Ala Gly Glu Val Pro Arg Glu
     205                 210                 215

 gag gaa gat gga ttg gtt gcc tgg ttt gct cta ggt ata gat cct att      843
 Glu Glu Asp Gly Leu Val Ala Trp Phe Ala Leu Gly Ile Asp Pro Ile
 220                 225                 230                 235

 gct gct gaa gaa ttc aag caa aga cat gaa aat tgt tac ttt ctt cat      891
 Ala Ala Glu Glu Phe Lys Gln Arg His Glu Asn Cys Tyr Phe Leu His
                 240                 245                 250

 cct cct atg cca gcc ctt ctg caa ttg aaa gaa aaa gaa gct ggt aag      939
 Pro Pro Met Pro Ala Leu Leu Gln Leu Lys Glu Lys Glu Ala Gly Lys
             255                 260                 265

 aaa tga atgctgcttt tcattggtaa aatcctggtt tttagacttg agttggagtt       995
 Lys 






      <210> 206
      <211> 786
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(498)

      <400> 206
 gttctggtgg caaacgactg ctgtgggatt ctggtgtgtg atgggaatga gccacctcag     60
                                                                 
 atg tgg agg gcc ctg aag aat cca aca gca cat ccg gtg tgg tcg acg      108
 Met Trp Arg Ala Leu Lys Asn Pro Thr Ala His Pro Val Trp Ser Thr
   1               5                  10                  15

 ggt cct cca aga gtt tgg ggc gcg gac cgg agt acc ttg cgt gca gtt      156
 Gly Pro Pro Arg Val Trp Gly Ala Asp Arg Ser Thr Leu Arg Ala Val
              20                  25                  30

 atg tcg gcg tcg gta gtg tct gtc att tcg cgg ttc tta gaa gag tac      204
 Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr
          35                  40                  45

 ttg agc tcc act ccg cag cgt ctg aag ttg ctg gac gcg tac ctg ctg      252
 Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu
      50                  55                  60

 tat ata ctg ctg acc ggg gcg ctg cag ttc ggt tac tgt ctc ctc gtg      300
 Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val
  65                  70                  75                  80

 ggg acc ttc ccc ttc aac tct ttt ctc tcg ggc ttc atc tct tgt gtg      348
 Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val
                  85                  90                  95

 ggg agt ttc atc cta gcg gtt tgc ctg aga ata cag atc aac cca cag      396
 Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln
             100                 105                 110

 aac aaa gcg gat ttc caa ggc atc tcc cca gag cga gcc ttt gct gat      444
 Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp
         115                 120                 125

 ttt ctc ttt gcc agc acc atc ctg cac ctt gtt gtc atg aac ttt gtt      492
 Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val
     130                 135                 140

 ggc tga ctcattctca tttacttaat tgaggagtag gagactaaaa gaatgttcac       548
 Gly 
 145

 tctttgaatt tcctggataa gagttctgga gatggcagct tattggacac atggattttc    608

 ttcagatttg cacttactgc tagctctgct ttttatgcag gagaaaagcc cagagttcac    668

 tgtgtgtcag aacaactttc taacaaacat ttattaatcc agcctctgcc tttcattaaa    728

 tgtaaccttt tgccttccaa attaaagaac tccatgccac tcctccaaaa aaaaaaaa      786




      <210> 207
      <211> 1735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (322)..(1593)

      <400> 207
 ggccgtgggc tggcgttgcc gcgctacggt catgccgggt ccgcacgacc ccagagttcg     60

 gagccgggtg cccggaagcc gcactggagg actgtgcggc ggcgatgggg cgtccagccg    120

 tcgcggcgag acgcagaggg accaccccat tgcacaggcg cggagactga ggcccgcagg    180

 ggccgcgcct ggcacgatcg cccgtcggga cctggagccc cggacagaga ggtgaagaag    240

 gaggggccgg cgtcagtgac gtcagcgaga ccgaggtgag cgtgggcgtt gccagtggtg    300

 ctctgtcagt gcctatggat t  atg gca ggg aaa gta aaa tgg gtc act gat     351
                          Met Ala Gly Lys Val Lys Trp Val Thr Asp
                            1               5                  10

 atc gag aag tca gtg ctg atc aat aac ttt gaa aag aga gga tgg gtc      399
 Ile Glu Lys Ser Val Leu Ile Asn Asn Phe Glu Lys Arg Gly Trp Val
                  15                  20                  25

 caa gtg aca gaa aac gag gac tgg aat ttt tac tgg atg agt gtg caa      447
 Gln Val Thr Glu Asn Glu Asp Trp Asn Phe Tyr Trp Met Ser Val Gln
              30                  35                  40

 acc atc cga aat gtg ttc agc gtt gaa gct gga tat cgg ctc tca gat      495
 Thr Ile Arg Asn Val Phe Ser Val Glu Ala Gly Tyr Arg Leu Ser Asp
          45                  50                  55

 gac caa ata gtc aac cat ttt cca aac cac tat gaa ctg acc cgg aag      543
 Asp Gln Ile Val Asn His Phe Pro Asn His Tyr Glu Leu Thr Arg Lys
      60                  65                  70

 gac ctg atg gtg aag aac atc aaa aga tac agg aag gag ctg gag aaa      591
 Asp Leu Met Val Lys Asn Ile Lys Arg Tyr Arg Lys Glu Leu Glu Lys
  75                  80                  85                  90

 gaa ggg agt cct ctg gca gaa aaa gat gaa aat gga aaa tac ctc tat      639
 Glu Gly Ser Pro Leu Ala Glu Lys Asp Glu Asn Gly Lys Tyr Leu Tyr
                  95                 100                 105

 ctg gac ttt gtt cca gtc acc tat atg ctg ccc gct gac tac aac ctg      687
 Leu Asp Phe Val Pro Val Thr Tyr Met Leu Pro Ala Asp Tyr Asn Leu
             110                 115                 120

 ttt gta gag gag ttc cgg aag agc ccg tcc agc acc tgg atc atg aag      735
 Phe Val Glu Glu Phe Arg Lys Ser Pro Ser Ser Thr Trp Ile Met Lys
         125                 130                 135

 cct tgt ggc aag gcc cag gga aag ggc atc ttc ctt atc aac aag ctc      783
 Pro Cys Gly Lys Ala Gln Gly Lys Gly Ile Phe Leu Ile Asn Lys Leu
     140                 145                 150

 tca cag atc aaa aag tgg tcc cgg gac agc aag aca tct tcg ttt gtg      831
 Ser Gln Ile Lys Lys Trp Ser Arg Asp Ser Lys Thr Ser Ser Phe Val
 155                 160                 165                 170

 tct caa tct aat aag gaa gcc tac gtg atc tct ctc tat att aac aac      879
 Ser Gln Ser Asn Lys Glu Ala Tyr Val Ile Ser Leu Tyr Ile Asn Asn
                 175                 180                 185

 ccg tta cta att ggc ggg agg aag ttc gac ctg cgc ttg tac gtt ctg      927
 Pro Leu Leu Ile Gly Gly Arg Lys Phe Asp Leu Arg Leu Tyr Val Leu
             190                 195                 200

 gtg tcc acg tac cgt cca ctg cgc tgt tac atg tac aag ctt ggg ttt      975
 Val Ser Thr Tyr Arg Pro Leu Arg Cys Tyr Met Tyr Lys Leu Gly Phe
         205                 210                 215

 tgc cgg ttc tgc aca gtg aaa tac acc ccg agt acc agt gag ctg gac     1023
 Cys Arg Phe Cys Thr Val Lys Tyr Thr Pro Ser Thr Ser Glu Leu Asp
     220                 225                 230

 aac atg ttc gtt cat ctt acc aac gtc gcc atc cag aaa cac ggg gaa     1071
 Asn Met Phe Val His Leu Thr Asn Val Ala Ile Gln Lys His Gly Glu
 235                 240                 245                 250

 gac tac aac cac atc cat ggg ggc aag tgg aca gtg agt aac ctg cgg     1119
 Asp Tyr Asn His Ile His Gly Gly Lys Trp Thr Val Ser Asn Leu Arg
                 255                 260                 265

 ctc tac ctg gag agc acc cgc ggc aag gag gtg acc agc aag ctg ttc     1167
 Leu Tyr Leu Glu Ser Thr Arg Gly Lys Glu Val Thr Ser Lys Leu Phe
             270                 275                 280

 gac gag atc cac tgg atc atc gtg cag tcc ctg aag gct gtg gcg ccg     1215
 Asp Glu Ile His Trp Ile Ile Val Gln Ser Leu Lys Ala Val Ala Pro
         285                 290                 295

 gtg atg aac aat gac aag cac tgc ttt gaa tgc tat ggc tac gac atc     1263
 Val Met Asn Asn Asp Lys His Cys Phe Glu Cys Tyr Gly Tyr Asp Ile
     300                 305                 310

 atc atc gac gac aag ctg aag ccc tgg ctg atc gag gtg aat gcg tcc     1311
 Ile Ile Asp Asp Lys Leu Lys Pro Trp Leu Ile Glu Val Asn Ala Ser
 315                 320                 325                 330

 ccg tct ctc acg tcc agc act gcc aat gac cga atc ctc aag tac aac     1359
 Pro Ser Leu Thr Ser Ser Thr Ala Asn Asp Arg Ile Leu Lys Tyr Asn
                 335                 340                 345

 ctg att aat gac acc ctc aac atc gcc gtc ccg aat ggt gaa atc cca     1407
 Leu Ile Asn Asp Thr Leu Asn Ile Ala Val Pro Asn Gly Glu Ile Pro
             350                 355                 360

 gac tgc aaa tgg aac aag tcg cca cct aag gaa gtc ctc ggc aat tac     1455
 Asp Cys Lys Trp Asn Lys Ser Pro Pro Lys Glu Val Leu Gly Asn Tyr
         365                 370                 375

 gag att ctg tat gat gaa gaa ttg gcc cag ggt gac ggg gct gac cgg     1503
 Glu Ile Leu Tyr Asp Glu Glu Leu Ala Gln Gly Asp Gly Ala Asp Arg
     380                 385                 390

 gag ctg aga agc cgt cag ggt cag tct ctg ggg ccc aga gca ggc cga     1551
 Glu Leu Arg Ser Arg Gln Gly Gln Ser Leu Gly Pro Arg Ala Gly Arg
 395                 400                 405                 410

 tcg aga gac tca ggg aga gcg gtc ctc acc acc tgg aag tga gtcccac     1600
 Ser Arg Asp Ser Gly Arg Ala Val Leu Thr Thr Trp Lys 
                 415                 420

 ctggacctta tcaaaactac tcactccacc tgggcccctg ctgaagccct attttgaaat   1660

 ttcccttttg tagagctttt ttcctttcct aagccctgta aataaacgaa ggcacttctt   1720

 tggaaaaaaa aaaaa                                                    1735




      <210> 208
      <211> 1200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(926)

      <400> 208
 ggagccccgg cagcaggagc gtcgcaggtc cttggccctt gccagacatt agcacc         56                                                                 
 atg agc ttc gtg gca tac gag gag ctg atc aag gag ggt gac acg gcc      104
 Met Ser Phe Val Ala Tyr Glu Glu Leu Ile Lys Glu Gly Asp Thr Ala
   1               5                  10                  15

 atc ctg tca ctg ggc cat ggt gca atg gtg gca gtg cgt gtg cag cgt      152
 Ile Leu Ser Leu Gly His Gly Ala Met Val Ala Val Arg Val Gln Arg
              20                  25                  30

 ggg gca cag acc cag acc cgg cat ggt gtc ctg cgg cac tca gtt gac      200
 Gly Ala Gln Thr Gln Thr Arg His Gly Val Leu Arg His Ser Val Asp
          35                  40                  45

 ctt atc ggc cgc ccc ttc ggc tcc aag gtg acg tgc ggc cga ggt ggc      248
 Leu Ile Gly Arg Pro Phe Gly Ser Lys Val Thr Cys Gly Arg Gly Gly
      50                  55                  60

 tgg gtg tat gtg ctg cac ccc acg ccc gag ctc tgg acg ctg aac ctg      296
 Trp Val Tyr Val Leu His Pro Thr Pro Glu Leu Trp Thr Leu Asn Leu
  65                  70                  75                  80

 ccg cac cgc acg cag atc ctc tac tcc aca gac atc gcc ctc atc acc      344
 Pro His Arg Thr Gln Ile Leu Tyr Ser Thr Asp Ile Ala Leu Ile Thr
                  85                  90                  95

 atg atg ttg gag ctt cgg ccc ggc tct gtg gtc tgt gag tct ggc acc      392
 Met Met Leu Glu Leu Arg Pro Gly Ser Val Val Cys Glu Ser Gly Thr
             100                 105                 110

 ggc agt ggc tct gtg tcc cac gcc atc atc cgc acc att gca ccc acg      440
 Gly Ser Gly Ser Val Ser His Ala Ile Ile Arg Thr Ile Ala Pro Thr
         115                 120                 125

 ggt cac ctg cac acg gtg gag ttc cac cag cag cgg gca gag aag gcc      488
 Gly His Leu His Thr Val Glu Phe His Gln Gln Arg Ala Glu Lys Ala
     130                 135                 140

 cgg gag gag ttc cag gag cac cgt gtg ggc cgc tgg gtg act gtg cgc      536
 Arg Glu Glu Phe Gln Glu His Arg Val Gly Arg Trp Val Thr Val Arg
 145                 150                 155                 160

 acc cag gac gtg tgc cgc agt ggc ttt ggc gtg agc cac gtg gcc gac      584
 Thr Gln Asp Val Cys Arg Ser Gly Phe Gly Val Ser His Val Ala Asp
                 165                 170                 175

 gcc gtc ttc ctg gac atc cca tca ccc tgg gag gcc gtg ggc cac gcc      632
 Ala Val Phe Leu Asp Ile Pro Ser Pro Trp Glu Ala Val Gly His Ala
             180                 185                 190

 tgg gac gcc ctc aag gtc gaa ggc ggg cgc ttc tgc tcc ttc tca ccg      680
 Trp Asp Ala Leu Lys Val Glu Gly Gly Arg Phe Cys Ser Phe Ser Pro
         195                 200                 205

 tgc atc gag cag gtg caa cgc aca tgc cag gcg ctg gca gcg cgc ggc      728
 Cys Ile Glu Gln Val Gln Arg Thr Cys Gln Ala Leu Ala Ala Arg Gly
     210                 215                 220

 ttc tca gag ctg agc acc ctg gag gtg ctg cca cag gtc tac aac gtg      776
 Phe Ser Glu Leu Ser Thr Leu Glu Val Leu Pro Gln Val Tyr Asn Val
 225                 230                 235                 240

 cgc act gtc agc ctg cca ccg ccc gac ctg ggc aca ggc aca gat ggc      824
 Arg Thr Val Ser Leu Pro Pro Pro Asp Leu Gly Thr Gly Thr Asp Gly
                 245                 250                 255

 cct gcc ggc tcc gac acc agc ccc ttc cgc agc ggc acg ccc atg aag      872
 Pro Ala Gly Ser Asp Thr Ser Pro Phe Arg Ser Gly Thr Pro Met Lys
             260                 265                 270

 gag gcc gtg ggc cac acc ggc tac ctg acc ttc gcc acc aag acc cca      920
 Glu Ala Val Gly His Thr Gly Tyr Leu Thr Phe Ala Thr Lys Thr Pro
         275                 280                 285

 ggc tag ggggccgcct cccagggcac cagggagctg ggagcactga agggctgggc       976
 Gly 


 agggaggcca gaggcacctt atatggtcag cgatgcctgc cagacacaga cggtggggtg   1036

 gggcttgggg gcctcctggg tggccagagt gggacagcag gaagggcggc tgtgatggag   1096

 gagcagtgct ggggctgggc ctcagccatt cctgtccagc cctgtggccc atcccagctg   1156

 ctgtttgttg ccaatatgaa gtatccactg ccaaaaaaaa aaaa                    1200




      <210> 209
      <211> 1725
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(1236)

      <400> 209
 gcggaagcgg aagagcaggt ctccagggga gcg atg gca gcc ggg ggt ctg agc      54
                                      Met Ala Ala Gly Gly Leu Ser
                                        1               5

 cgc tcc gag cgc aaa gcg gcg gag cgg gtc cgg agg ttg cgg gag gag      102
 Arg Ser Glu Arg Lys Ala Ala Glu Arg Val Arg Arg Leu Arg Glu Glu
          10                  15                  20

 cag cag agg gag cgc ctc cgc cag gtg tcg cgc atc ctg agg aag gcg      150
 Gln Gln Arg Glu Arg Leu Arg Gln Val Ser Arg Ile Leu Arg Lys Ala
      25                  30                  35

 gcg gcg gag cgc agc gcc gag gag ggc cgg ctg ctg gcc gag agc gcg      198
 Ala Ala Glu Arg Ser Ala Glu Glu Gly Arg Leu Leu Ala Glu Ser Ala
  40                  45                  50                  55

 gac ctg gta acg gag ctg cag ggc cgg agc cgg cgg cgc gag ggc ctg      246
 Asp Leu Val Thr Glu Leu Gln Gly Arg Ser Arg Arg Arg Glu Gly Leu
                  60                  65                  70

 aag cgg cgg cag gag gag gtg tgc gac gac ccg gag gag ctg cgg ggg      294
 Lys Arg Arg Gln Glu Glu Val Cys Asp Asp Pro Glu Glu Leu Arg Gly
              75                  80                  85

 aag gtc cgg gag ctg gcc agc gcc gtc cgg aac gcc aaa tac ttg gtc      342
 Lys Val Arg Glu Leu Ala Ser Ala Val Arg Asn Ala Lys Tyr Leu Val
          90                  95                 100

 gtc tac aca ggc gcg gga atc agc acg gca gcg tct atc cca gac tac      390
 Val Tyr Thr Gly Ala Gly Ile Ser Thr Ala Ala Ser Ile Pro Asp Tyr
     105                 110                 115

 cgg ggc cct aat gga gtg tgg aca ctg ctt cag aaa ggg aga agc gtt      438
 Arg Gly Pro Asn Gly Val Trp Thr Leu Leu Gln Lys Gly Arg Ser Val
 120                 125                 130                 135

 agt gct gcc gac ctg agc gag gcc gag cca acc ctc acc cac atg agc      486
 Ser Ala Ala Asp Leu Ser Glu Ala Glu Pro Thr Leu Thr His Met Ser
                 140                 145                 150

 atc acc cgt ctg cat gag cag aag ctg gtg cag cat gtg gtg tct cag      534
 Ile Thr Arg Leu His Glu Gln Lys Leu Val Gln His Val Val Ser Gln
             155                 160                 165

 aac tgt gac ggg ctc cac ctg agg agt ggg ctg ccg cgc acg gcc atc      582
 Asn Cys Asp Gly Leu His Leu Arg Ser Gly Leu Pro Arg Thr Ala Ile
         170                 175                 180

 tcc gag ctc cac ggg aac atg tac att gaa gtc tgt acc tcc tgc gtt      630
 Ser Glu Leu His Gly Asn Met Tyr Ile Glu Val Cys Thr Ser Cys Val
     185                 190                 195

 ccc aac agg gag tac gtg cgg gtg ttc gat gtg acg gag cgc act gcc      678
 Pro Asn Arg Glu Tyr Val Arg Val Phe Asp Val Thr Glu Arg Thr Ala
 200                 205                 210                 215

 ctc cac aga cac cag aca ggc cgg acc tgc cac aag tgt ggg acc cag      726
 Leu His Arg His Gln Thr Gly Arg Thr Cys His Lys Cys Gly Thr Gln
                 220                 225                 230

 ctg cgg gac acc att gtg cac ttt ggg gag agg ggg acg ttg ggg cag      774
 Leu Arg Asp Thr Ile Val His Phe Gly Glu Arg Gly Thr Leu Gly Gln
             235                 240                 245

 cct ctg aac tgg gaa gcg gcg acc gag gct gcc agc aga gca gac acc      822
 Pro Leu Asn Trp Glu Ala Ala Thr Glu Ala Ala Ser Arg Ala Asp Thr
         250                 255                 260

 atc ctg tgt cta ggg tcc agc ctg aag gtt cta aag aag tac cca cgc      870
 Ile Leu Cys Leu Gly Ser Ser Leu Lys Val Leu Lys Lys Tyr Pro Arg
     265                 270                 275

 ctc tgg tgc atg acc aag ccc cct agc cgg cgg ccg aag ctt tac atc      918
 Leu Trp Cys Met Thr Lys Pro Pro Ser Arg Arg Pro Lys Leu Tyr Ile
 280                 285                 290                 295

 gtg aac ctg cag tgg acc ccg aag gat gac tgg gct gcc ctg aag cta      966
 Val Asn Leu Gln Trp Thr Pro Lys Asp Asp Trp Ala Ala Leu Lys Leu
                 300                 305                 310

 cat ggg aag tgt gat gac gtc atg cgg ctc ctc atg gcc gag ctg ggc     1014
 His Gly Lys Cys Asp Asp Val Met Arg Leu Leu Met Ala Glu Leu Gly
             315                 320                 325

 ttg gag atc ccc gcc tat agc agg tgg cag gat ccc att ttc tca ctg     1062
 Leu Glu Ile Pro Ala Tyr Ser Arg Trp Gln Asp Pro Ile Phe Ser Leu
         330                 335                 340

 gcg act ccc ctg cgt gct ggt gaa gaa ggc agc cac agt cgg aag tcg     1110
 Ala Thr Pro Leu Arg Ala Gly Glu Glu Gly Ser His Ser Arg Lys Ser
     345                 350                 355

 ctg tgc aga agc aga gag gag gcc ccg cct ggg gac cgg ggt gca ccg     1158
 Leu Cys Arg Ser Arg Glu Glu Ala Pro Pro Gly Asp Arg Gly Ala Pro
 360                 365                 370                 375

 ctt agc tcg gcc ccc atc cta ggg ggc tgg ttt ggc agg ggc tgc aca     1206
 Leu Ser Ser Ala Pro Ile Leu Gly Gly Trp Phe Gly Arg Gly Cys Thr
                 380                 385                 390

 aaa cgc aca aaa agg aag aaa gtg acg taa t cacgtgctcg atgaagaaca     1257
 Lys Arg Thr Lys Arg Lys Lys Val Thr 
             395                 400

 gttggcactt tgcagatggc cagtgtcacg gtgaaggctg ggttgccccc acgggtctag   1317

 ggagaacgaa ctctttgggg atgacatttt caccgtgaca tttttagcca tttgtccttg   1377

 aggaagcccc ttgcactgct gcggttgtac cctgatacgg cctggccatc gaggacacct   1437

 gcccatccgg cctctgtgtc aagaggtggc agccgcacct ttctgtgaga acggaactcg   1497

 ggttatttca gccccggcct gcagagtgga agcgcccagc ggcctttcct cgctcaccag   1557

 gccagtctca gggcctcacc gtatttctac tactacttaa tgaaaaagtg tgaactttat   1617

 agaatcctct ctgtactgga tgtgcggcag aggggtggct ccgagcctcg gctctatgca   1677

 gaccttttta tttctattaa acgtttctgc actggcaaaa aaaaaaaa                1725




      <210> 210
      <211> 1096
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(1046)

      <400> 210
 aggcagtagc taaggaaata ttgtggcgtc aaattgtcgg tagcatcaac acttcgtagg     60

 atttgctgca tgtgtgggtg ctgagccgcc cgccgcctgg agggggagac agcttcagga    120

 cacgcaggcc gcagcgaggg cccgggccct ggggatccca ggcc atg gat gct ccc     176
                                                  Met Asp Ala Pro
                                                    1

 cac tcc aaa gca gcc ctg gac agc att aac gag ctg ccc gag aac atc      224
 His Ser Lys Ala Ala Leu Asp Ser Ile Asn Glu Leu Pro Glu Asn Ile
   5                  10                  15                  20

 ctg ctg gag ctg ttc acg cac gtg ccc gcc cgc cag ctg ctg ctg aac      272
 Leu Leu Glu Leu Phe Thr His Val Pro Ala Arg Gln Leu Leu Leu Asn
                  25                  30                  35

 tgc cgc ctg gtc tgc agc ctc tgg cgg gac ctc atc gac ctc atg acc      320
 Cys Arg Leu Val Cys Ser Leu Trp Arg Asp Leu Ile Asp Leu Met Thr
              40                  45                  50

 ctc tgg aaa cgc aag tgc ctg cga gag ggc ttc atc acc aag gac tgg      368
 Leu Trp Lys Arg Lys Cys Leu Arg Glu Gly Phe Ile Thr Lys Asp Trp
          55                  60                  65

 gac cag ccc gtg gcc gac tgg aaa atc ttc tac ttc cta cgg agc ctg      416
 Asp Gln Pro Val Ala Asp Trp Lys Ile Phe Tyr Phe Leu Arg Ser Leu
      70                  75                  80

 cat agg aac ctc ctg cgc aac ccg tgt gct gaa gag gat atg ttt gca      464
 His Arg Asn Leu Leu Arg Asn Pro Cys Ala Glu Glu Asp Met Phe Ala
  85                  90                  95                 100

 tgg caa att gat ttc aat ggt ggg gac cgc tgg aag gtg gag agc ctc      512
 Trp Gln Ile Asp Phe Asn Gly Gly Asp Arg Trp Lys Val Glu Ser Leu
                 105                 110                 115

 cct gga gcc cac ggg aca gat ttt cct gac ccc aaa gtc aag aag tat      560
 Pro Gly Ala His Gly Thr Asp Phe Pro Asp Pro Lys Val Lys Lys Tyr
             120                 125                 130

 ttt gtc aca tcc tac gaa atg tgc ctc aag tcc cag ctg gtg gac ctt      608
 Phe Val Thr Ser Tyr Glu Met Cys Leu Lys Ser Gln Leu Val Asp Leu
         135                 140                 145

 gta gcc gag ggc tac tgg gag gag cta cta gac aca ttc cgg ccg gac      656
 Val Ala Glu Gly Tyr Trp Glu Glu Leu Leu Asp Thr Phe Arg Pro Asp
     150                 155                 160

 atc gtg gtt aag gac tgg ttt gct gcc aga gcc gac tgt ggc tgc acc      704
 Ile Val Val Lys Asp Trp Phe Ala Ala Arg Ala Asp Cys Gly Cys Thr
 165                 170                 175                 180

 tac caa ctc aaa gtg cag ctg gcc tcg gct gac tac ttc gtg ttg gcc      752
 Tyr Gln Leu Lys Val Gln Leu Ala Ser Ala Asp Tyr Phe Val Leu Ala
                 185                 190                 195

 tcc ttc gag ccc cca cct gtg acc atc caa cag tgg aac aat gcc aca      800
 Ser Phe Glu Pro Pro Pro Val Thr Ile Gln Gln Trp Asn Asn Ala Thr
             200                 205                 210

 tgg aca gag gtc tcc tac acc ttc tca gac tac ccc cgg ggt gtc cgc      848
 Trp Thr Glu Val Ser Tyr Thr Phe Ser Asp Tyr Pro Arg Gly Val Arg
         215                 220                 225

 tac atc ctc ttc cag cat ggg ggc agg gac acc cag tac tgg gca ggc      896
 Tyr Ile Leu Phe Gln His Gly Gly Arg Asp Thr Gln Tyr Trp Ala Gly
     230                 235                 240

 tgg tat ggg ccc cga gtc acc aac agc agc att gtc gtc agc ccc aag      944
 Trp Tyr Gly Pro Arg Val Thr Asn Ser Ser Ile Val Val Ser Pro Lys
 245                 250                 255                 260

 atg acc agg aac cag gcc tcc tcc gag gct cag cct ggg cag aag cat      992
 Met Thr Arg Asn Gln Ala Ser Ser Glu Ala Gln Pro Gly Gln Lys His
                 265                 270                 275

 gga cag gag gag gct gcc caa tcg ccc tac cga gct gtt gtc cag att     1040
 Gly Gln Glu Glu Ala Ala Gln Ser Pro Tyr Arg Ala Val Val Gln Ile
             280                 285                 290

 ttc tga cagctgtcca tcctgtgtct gggtcagcca gaggttcctc caggcaggag      1096
 Phe 






      <210> 211
      <211> 1827
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(1777)

      <400> 211
 gcacgagccc tatgagtgct gtgaatgtgg gaaagtcttc agtaggaaag accagcttgt     60

 ttcacaccag aaaactcatt caggacagaa accatatgtg tgtaatgaat gtgggaaagc    120

 ttttggttta aaatcacagc tcattataca tgaaagaatt catacaggag agaaaccata    180

 tgaatgcaat gaatgtcaga aagcctttaa tacaaagtca aacctt   atg gta cat     235
                                                      Met Val His
                                                        1

 cag aga acc cat aca ggg gag aaa cct tat gtt tgt agt gat tgt gga      283
 Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp Cys Gly
       5                  10                  15

 aaa gcc ttt aca ttc aag tca cag ctc att gta cat cag ggg att cac      331
 Lys Ala Phe Thr Phe Lys Ser Gln Leu Ile Val His Gln Gly Ile His
  20                  25                  30                  35

 aca gga gta aag ccc tat ggg tgt att cag tgt ggt aaa gga ttc agt      379
 Thr Gly Val Lys Pro Tyr Gly Cys Ile Gln Cys Gly Lys Gly Phe Ser
                  40                  45                  50

 ttg aaa tca cag ctc att gta cat cag aga agt cac aca gga atg aaa      427
 Leu Lys Ser Gln Leu Ile Val His Gln Arg Ser His Thr Gly Met Lys
              55                  60                  65

 cct tat gta tgc aat gaa tgt ggc aaa gcc ttc agg agc aag tca tac      475
 Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Arg Ser Lys Ser Tyr
          70                  75                  80

 ctt att ata cat aca agg act cat aca gga gaa aaa ctc cat gaa tgc      523
 Leu Ile Ile His Thr Arg Thr His Thr Gly Glu Lys Leu His Glu Cys
      85                  90                  95

 aac aat tgt ggg aaa gcc ttc agt ttt aaa tca cag ctc att ata cat      571
 Asn Asn Cys Gly Lys Ala Phe Ser Phe Lys Ser Gln Leu Ile Ile His
 100                 105                 110                 115

 cag agg att cat aca gga gag aac ccc tat gaa tgc cat gaa tgt ggg      619
 Gln Arg Ile His Thr Gly Glu Asn Pro Tyr Glu Cys His Glu Cys Gly
                 120                 125                 130

 aaa gcc ttc agt cgg aaa tac cag ctt att tca cac cag aga act cat      667
 Lys Ala Phe Ser Arg Lys Tyr Gln Leu Ile Ser His Gln Arg Thr His
             135                 140                 145

 gca gga gag aag cct tat gaa tgc acc gac tgt gga aag gct ttt ggt      715
 Ala Gly Glu Lys Pro Tyr Glu Cys Thr Asp Cys Gly Lys Ala Phe Gly
         150                 155                 160

 tta aag tca cag ctt att ata cac cag aga act cat aca ggg gag aaa      763
 Leu Lys Ser Gln Leu Ile Ile His Gln Arg Thr His Thr Gly Glu Lys
     165                 170                 175

 cca ttt gaa tgt agt gag tgt cag aaa gcc ttt aat aca aag tca aac      811
 Pro Phe Glu Cys Ser Glu Cys Gln Lys Ala Phe Asn Thr Lys Ser Asn
 180                 185                 190                 195

 ctg att gta cat cag aga act cat aca gga gag aaa ccc tat agt tgt      859
 Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ser Cys
                 200                 205                 210

 aat gaa tgt gga aaa gcc ttt acg ttc aaa tca cag ctc att gta cat      907
 Asn Glu Cys Gly Lys Ala Phe Thr Phe Lys Ser Gln Leu Ile Val His
             215                 220                 225

 aaa gga gtg cac act gga gta aaa ccc tat gga tgc agt caa tgt gca      955
 Lys Gly Val His Thr Gly Val Lys Pro Tyr Gly Cys Ser Gln Cys Ala
         230                 235                 240

 aaa acc ttt agt ttg aag tcc cag ctc att gta cat cag aga agt cac     1003
 Lys Thr Phe Ser Leu Lys Ser Gln Leu Ile Val His Gln Arg Ser His
     245                 250                 255

 aca gga gta aaa cca tat gga tgc agt gag tgt ggg aaa gcc ttc agg     1051
 Thr Gly Val Lys Pro Tyr Gly Cys Ser Glu Cys Gly Lys Ala Phe Arg
 260                 265                 270                 275

 agc aag tca tac ctt att ata cat atg aga act cat aca gga gag aaa     1099
 Ser Lys Ser Tyr Leu Ile Ile His Met Arg Thr His Thr Gly Glu Lys
                 280                 285                 290

 cca cat gag tgc agg gaa tgc ggg aaa tcc ttt agt ttc aat tca caa     1147
 Pro His Glu Cys Arg Glu Cys Gly Lys Ser Phe Ser Phe Asn Ser Gln
             295                 300                 305

 ctc att gtg cat cag aga att cac aca gga gaa aat ccc tat gaa tgc     1195
 Leu Ile Val His Gln Arg Ile His Thr Gly Glu Asn Pro Tyr Glu Cys
         310                 315                 320

 agt gaa tgt ggg aaa gcc ttt aat agg aaa gac cag ctc att tca cat     1243
 Ser Glu Cys Gly Lys Ala Phe Asn Arg Lys Asp Gln Leu Ile Ser His
     325                 330                 335

 cag cga act cat gca ggg gaa aag cct tat ggg tgc agt gaa tgt ggg     1291
 Gln Arg Thr His Ala Gly Glu Lys Pro Tyr Gly Cys Ser Glu Cys Gly
 340                 345                 350                 355

 aaa gct ttt agc agc aag tca tac cta att ata cac atg aga act cat     1339
 Lys Ala Phe Ser Ser Lys Ser Tyr Leu Ile Ile His Met Arg Thr His
                 360                 365                 370

 tca ggt gaa aaa cca tat gaa tgt aat gaa tgt ggg aaa gcc ttc att     1387
 Ser Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ile
             375                 380                 385

 tgg aaa tca cta ctc att gta cat gag cga act cat gca ggg gtc aac     1435
 Trp Lys Ser Leu Leu Ile Val His Glu Arg Thr His Ala Gly Val Asn
         390                 395                 400

 cct tat aaa tgc agt caa tgt gag aaa tcc ttc agt ggg aaa tta cgc     1483
 Pro Tyr Lys Cys Ser Gln Cys Glu Lys Ser Phe Ser Gly Lys Leu Arg
     405                 410                 415

 ctt ctt gta cac cag aga atg cac aca aca gag aaa cca tat gaa tgc     1531
 Leu Leu Val His Gln Arg Met His Thr Thr Glu Lys Pro Tyr Glu Cys
 420                 425                 430                 435

 agt gag tgt gga aaa gcc ttc att agg aat tct caa ctc att gta cat     1579
 Ser Glu Cys Gly Lys Ala Phe Ile Arg Asn Ser Gln Leu Ile Val His
                 440                 445                 450

 caa aga act cat tca gga gag aaa ccc tat ggg tgc aat gaa tgt ggg     1627
 Gln Arg Thr His Ser Gly Glu Lys Pro Tyr Gly Cys Asn Glu Cys Gly
             455                 460                 465

 aaa acc ttc tct caa aaa tca att ctc agt gca cat cag aga aca cat     1675
 Lys Thr Phe Ser Gln Lys Ser Ile Leu Ser Ala His Gln Arg Thr His
         470                 475                 480

 aca gga gag aag cct tgt aag tgc act gaa tgt ggg aaa gcc ttt tgt     1723
 Thr Gly Glu Lys Pro Cys Lys Cys Thr Glu Cys Gly Lys Ala Phe Cys
     485                 490                 495

 tgg aag tca cag ctc att atg cat cag aga act cat gta gat gac aaa     1771
 Trp Lys Ser Gln Leu Ile Met His Gln Arg Thr His Val Asp Asp Lys
 500                 505                 510                 515

 cat tga taattttacg aaactctgaa aagtggattc acaagagata gaaacaatca      1827
 His 






      <210> 212
      <211> 1475
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(812)

      <400> 212
 gctatcttaa tgagctcaag tggtcctttg ctgttgctac catcacagaa atcccccccg     60

 ttatcttcct ccccaacttc cttgtgcaga ggaaggtgct gaggcccctt cggacccaga    120

 caggaggaac cata  atg gcg ggg aag ctg gct gtg gag cga ggc tgg gcc     170
                  Met Ala Gly Lys Leu Ala Val Glu Arg Gly Trp Ala
                    1               5                  10

 atc aac gtg ggg ggt ggc ttc cac cac tgc tcc agc gac cgt ggc ggg      218
 Ile Asn Val Gly Gly Gly Phe His His Cys Ser Ser Asp Arg Gly Gly
          15                  20                  25

 ggc ttc tgt gcc tat gcg gac atc acg ctc gcc atc aag ttt ctg ttt      266
 Gly Phe Cys Ala Tyr Ala Asp Ile Thr Leu Ala Ile Lys Phe Leu Phe
      30                  35                  40

 gag cgt gtg gag ggc atc tcc agg gct acc atc att gat ctt gat gcc      314
 Glu Arg Val Glu Gly Ile Ser Arg Ala Thr Ile Ile Asp Leu Asp Ala
  45                  50                  55                  60

 cat cag ggc aat ggg cat gag cga gac ttc atg gac gac aag cgt gtg      362
 His Gln Gly Asn Gly His Glu Arg Asp Phe Met Asp Asp Lys Arg Val
                  65                  70                  75

 tac atc atg gat gtc tac aac cgc cac atc tac cca ggg gac cgc ttt      410
 Tyr Ile Met Asp Val Tyr Asn Arg His Ile Tyr Pro Gly Asp Arg Phe
              80                  85                  90

 gcc aag cag gcc atc agg cgg aag gtg gag ctg gag tgg ggc aca gag      458
 Ala Lys Gln Ala Ile Arg Arg Lys Val Glu Leu Glu Trp Gly Thr Glu
          95                 100                 105

 gat gat gag tac ctg gat aag gtg gag agg aac atc aag aaa tcc ctc      506
 Asp Asp Glu Tyr Leu Asp Lys Val Glu Arg Asn Ile Lys Lys Ser Leu
     110                 115                 120

 cag gag cac ctg ccc gac gtg gtg gta tac aat gca ggc acc gac atc      554
 Gln Glu His Leu Pro Asp Val Val Val Tyr Asn Ala Gly Thr Asp Ile
 125                 130                 135                 140

 ctc gag ggg gac cgc ctt ggg ggg ctg tcc atc agc cca gcg ggc atc      602
 Leu Glu Gly Asp Arg Leu Gly Gly Leu Ser Ile Ser Pro Ala Gly Ile
                 145                 150                 155

 gtg aag cgg gat gag ctg gtg ttc cgg atg gtc cgt ggc cgc cgg gtg      650
 Val Lys Arg Asp Glu Leu Val Phe Arg Met Val Arg Gly Arg Arg Val
             160                 165                 170

 ccc atc ctt atg gtg acc tca ggc ggg tac cag aag cgc aca gcc cgc      698
 Pro Ile Leu Met Val Thr Ser Gly Gly Tyr Gln Lys Arg Thr Ala Arg
         175                 180                 185

 atc att gct gac tcc ata ctt aat ctg ttt ggc ctg ggg ctc att ggg      746
 Ile Ile Ala Asp Ser Ile Leu Asn Leu Phe Gly Leu Gly Leu Ile Gly
     190                 195                 200

 cct gag tca ccc agc gtc tcc gca cag aac tca gac aca ccg ctg ctt      794
 Pro Glu Ser Pro Ser Val Ser Ala Gln Asn Ser Asp Thr Pro Leu Leu
 205                 210                 215                 220

 ccc cct gca gtg ccc tga cccttg ctgccctgcc tgtcacgtgg ccctgcctat      848
 Pro Pro Ala Val Pro 
                 225

 ccgcccctta gtgctttttg ttttctaacc tcatggggtg gtggaggcag ccttcagtga    908

 gcatggaggg gcagggccat ccctggctgg ggcctggagc tggcccttcc tctacttttc    968

 cctgctggaa gccagaaggg cttgaggcct ctatgggtgg gggcagaagg cagagcctgt   1028

 gtcccagggg gacccacacg aagtcaccag cccataggtc cagggaggca ggcagttaac   1088

 tgagaattgg agaggacagg ctaggtccca ggcacagcga gggccctggg cttggggtgt   1148

 tctggttttg agaacggcag acccaggtcg gagtgaggaa gcttccacct ccatcctgac   1208

 taggcctgca tcctaactgg gcctccctcc ctccccttgg tcatgggatt tgctgccctc   1268

 tttgccccag agctgaagag ctataggcac tggtgtggat ggcccaggag gtgctggagc   1328

 taggtctcca ggtgggcctg gttcccaggc agcaggtggg aaccctgggc ctggatgtga   1388

 ggggcggtca ggaaggggta caggtgggtt ccctcatctg gagttccccc tcaataaagc   1448

 aaggtctgga cctgcaaaaa aaaaaaa                                       1475




      <210> 213
      <211> 754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(685)

      <400> 213
 gccattaggt accggcccgg aattctcggg tcgacccacg cgtccgcaga acacaactgc     60

 cagtgggtgt gagctc    atg cac act gag atg cag gcc ctg cgt gcc gac     109
                      Met His Thr Glu Met Gln Ala Leu Arg Ala Asp
                        1               5                  10

 tgg aag cag tgg gaa gac agt gta ttc caa acg cag agc tgt ttg gag      157
 Trp Lys Gln Trp Glu Asp Ser Val Phe Gln Thr Gln Ser Cys Leu Glu
              15                  20                  25

 aac ctg gtc agc cag atg gcc ctt tcg gag cag gaa ttc tca ggc caa      205
 Asn Leu Val Ser Gln Met Ala Leu Ser Glu Gln Glu Phe Ser Gly Gln
          30                  35                  40

 gtg gct caa ctg gag cag gcc ctg gaa cag ttc agt gcc ctt ctg aaa      253
 Val Ala Gln Leu Glu Gln Ala Leu Glu Gln Phe Ser Ala Leu Leu Lys
      45                  50                  55

 acc tgg gct cag cag tta acc ctc ctg gaa ggc aag aac acg gat gag      301
 Thr Trp Ala Gln Gln Leu Thr Leu Leu Glu Gly Lys Asn Thr Asp Glu
  60                  65                  70                  75

 gag ata gtg gaa tgc tgg cac aaa gga caa gag ata ctg gat gct ttg      349
 Glu Ile Val Glu Cys Trp His Lys Gly Gln Glu Ile Leu Asp Ala Leu
                  80                  85                  90

 caa aaa gca gag cct aga aca gag gat ctc aag tct cag ctg aat gaa      397
 Gln Lys Ala Glu Pro Arg Thr Glu Asp Leu Lys Ser Gln Leu Asn Glu
              95                 100                 105

 ctt tgt cga ttt tcc aga gac ctg agt acc tac agt gga aaa gtt tct      445
 Leu Cys Arg Phe Ser Arg Asp Leu Ser Thr Tyr Ser Gly Lys Val Ser
         110                 115                 120

 ggc ttg att aaa gag tat aat tgt ctt tgt ttg caa gca tcc aag ggc      493
 Gly Leu Ile Lys Glu Tyr Asn Cys Leu Cys Leu Gln Ala Ser Lys Gly
     125                 130                 135

 tgc cag aat aaa gaa cag att tta cag caa aga ttt cga aag gcc ttc      541
 Cys Gln Asn Lys Glu Gln Ile Leu Gln Gln Arg Phe Arg Lys Ala Phe
 140                 145                 150                 155

 agg gat ttc cag cag tgg ttg gtt aat gca aaa atc act acc gcc aag      589
 Arg Asp Phe Gln Gln Trp Leu Val Asn Ala Lys Ile Thr Thr Ala Lys
                 160                 165                 170

 tgt ttt gat ata cct caa aat ata agt gaa gtt tca act agt ctt cag      637
 Cys Phe Asp Ile Pro Gln Asn Ile Ser Glu Val Ser Thr Ser Leu Gln
             175                 180                 185

 aaa ata cag gag ttt ttg tcg aaa gtg aag atg tgc agc aca ggc taa      685
 Lys Ile Gln Glu Phe Leu Ser Lys Val Lys Met Cys Ser Thr Gly 
         190                 195                 200

 acatgatgct gtctaagggg acttctgagt acccgctgac caagggaagc taaagggtca    745

 ggccaattt                                                            754




      <210> 214
      <211> 546
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(546)

      <400> 214
 cccagtgcca ctgcc atg atg gat gtg agt gaa ctt ggg gag tct gcc cgc      51
                  Met Met Asp Val Ser Glu Leu Gly Glu Ser Ala Arg
                    1               5                  10

 tac ctc cgc cag ggc tac cag gag atg acg aag gtg cac act atc cca       99
 Tyr Leu Arg Gln Gly Tyr Gln Glu Met Thr Lys Val His Thr Ile Pro
          15                  20                  25

 tgg gac ggg aag aag cga gtc tgg gtg cct gat gaa cag gac gcc tac      147
 Trp Asp Gly Lys Lys Arg Val Trp Val Pro Asp Glu Gln Asp Ala Tyr
      30                  35                  40

 gtg gag gcc gag gtc aag tcg gag gct acc ggg ggc aga gtc acc gtg      195
 Val Glu Ala Glu Val Lys Ser Glu Ala Thr Gly Gly Arg Val Thr Val
  45                  50                  55                  60

 gag acc aaa gac cag aag gtg ctg atg gtg cgt gaa gcc gag ctg cag      243
 Glu Thr Lys Asp Gln Lys Val Leu Met Val Arg Glu Ala Glu Leu Gln
                  65                  70                  75

 ccc atg aac ccg cct cgc ttc gac tta ctg gag gac atg gcc atg atg      291
 Pro Met Asn Pro Pro Arg Phe Asp Leu Leu Glu Asp Met Ala Met Met
              80                  85                  90

 acg cac ctg aac gag gcc tct gtg ctg cac aac ctg cgc cag cgc tat      339
 Thr His Leu Asn Glu Ala Ser Val Leu His Asn Leu Arg Gln Arg Tyr
          95                 100                 105

 gcc cgc tgg atg atc tat acc tac tca ggc ctc ttc tgt gtc acc atc      387
 Ala Arg Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Ile
     110                 115                 120

 aac ccc tac aaa tgg ctc cca gtc tat acg gcc tcc gta gtg gct gct      435
 Asn Pro Tyr Lys Trp Leu Pro Val Tyr Thr Ala Ser Val Val Ala Ala
 125                 130                 135                 140

 tac aag gga aag cgc cgc tca gat tcc ccg ccc cat ata tat gcg gtg      483
 Tyr Lys Gly Lys Arg Arg Ser Asp Ser Pro Pro His Ile Tyr Ala Val
                 145                 150                 155

 gcg gac aac gcc tac aac gac atg ctg cgc aac cga gac aac cag tcc      531
 Ala Asp Asn Ala Tyr Asn Asp Met Leu Arg Asn Arg Asp Asn Gln Ser
             160                 165                 170

 atg ctg atc acg tga                                                  546
 Met Leu Ile Thr 
         175





      <210> 215
      <211> 4269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2288)..(3871)

      <400> 215
 aaggagaaaa gagtgacagt acaattgcct acagaatcca tacagaagaa ccaggaagat     60

 aagctcaaga tggttcccag gaagcaaaga gaatttagcg gatctgacag agggaaactt    120

 ccaggaagtg aagaaaaaaa tcagggacca tcaatgattg gtcgaaaaga agagagatta    180

 ataactgaaa gaaaacacga acatctgaag aataaatcag caccaaaggt cgtcaagcaa    240

 aaggttatcg atgcacatct tgattcacag actcagaatt ttcagcaaac acaaatacag    300

 accgctgaaa gtaaagctga acataaaaaa ttgccccagc catataatag tctgcaggaa    360

 gaaaaatgtc tcgaagtcaa gggcatacaa gagaaacaag tcttctctaa tactaaagat    420

 tcaaagcaag agattacaca gaacaaatct ttcttttcct ctgtgaaaga atcccagcgg    480

 gatgatggaa aaggtgcctt aaatatagtg gaattcttga gaaaacgtga agaactgcaa    540

 cagattttgt cgagagtgaa acagtttgaa gcagagccaa ataaaagtgg ccttaaaaca    600

 tttcagacac tattaaatac tatcccagga tggctgataa gtgaagataa gagagaatat    660

 gcagttcaca ttgccatgga gaataattta gaaaaagtaa aagaagaaat aacacatatt    720

 aaaactcaag cggaagatat gcttgtgtcc tatgaaaata taattcagac agccatgatg    780

 tcctccaaaa caggaaaacc gggaaataaa cccactagtc ttgatgaaac atcatccaaa    840

 gtatctaatg ttcatgtcag caataataaa aatagtgaac agaaagaaaa taaaattgcc    900

 aaagagaaaa cagtacagca ccaagtaaca gctcatcatg aagcaactgt tcgtagtcac    960

 gtgaaaaccc atcaggaaat taaacttgat gatagcaaca ttcctcctcc ctctttaaaa   1020

 acacgcccac cgtcaccaac ttttatcaca atagaatcta ctgcccgacg aacagaaaac   1080

 cctactaaga acgagctttc tcagtcccct aaaaaggaca gttatgttga acccccacca   1140

 agaaggccca tgtcgcaaaa atctgaaatt cacagagcaa acacttcccc ttctccaccc   1200

 aggagtcgct ctgaacaact tgtcagactc aaagacacca ctgcaaagtt atccaaaggg   1260

 gccatcccat gtccagcagc aaccccggtt ccaattgtag agaagaggtc tgaaatcatc   1320

 atgtctcctg caacacttcg tcgtcaaatt aagatagaaa ctcgcggtac ggactctcca   1380

 cctacaatca caataccagt aaatataaat catgctgcta gtggttcctt cagagaatct   1440

 gtggacgctc aagaggaaat caggaaagtg gagaagagag ctacttatgt tcataaagat   1500

 ggactaaatt ccactgatca catggtgccc gacactgaaa gttatgatgc agttgaaatc   1560

 atccgcaagg ttgcagtgcc tcctcgcctg tcagagcaca cacagagata tgaagcggcc   1620

 aaccgaactg ttcaaatggc tgaaaatttc gtgaatgacc ctgaaaatga aataaacaga   1680

 tggttcaggg aatttgagca tggcccagtt tctgaagcaa agtcaaatag aagagtttat   1740

 gcaaagggag aaacaaacca taacatacaa caagaaagtc gtacattttg taaggaggaa   1800

 tttggattaa catctttagg aaacacgagt tttacagact tttcttgcaa acatcctaga   1860

 gaactgcgag aaaagattcc tgttaagcag cccaggatct gctctgaaac caggtctcta   1920

 agtgaacatt tctcaggcat ggatgcattt gagagtcaaa ttgttgagtc gaagatgaaa   1980

 acctcttcat cacatagctc agaagctggc aaatctggct gtgacttcaa gcatgcccca   2040

 ccaacctatg aggatgtcat tgctggacat attttagata tctctgattc acctaaagaa   2100

 gtaagaaaaa attttcaaaa gacgtggcaa gagagtggaa gagtttttaa aggcctggga   2160

 tatgcaaccg cagatgcttc tgcaactgag atgagaacca ccttccaaga ggaatctgca   2220

 tttataagtg aagctgctgc tccaagacaa ggaaatatgt atactttgtc aaaagacagt   2280

 ttatcca  atg gag tgc cta gtg gca gac aag cag aat ttt cat aag tcc    2329
          Met Glu Cys Leu Val Ala Asp Lys Gln Asn Phe His Lys Ser
            1               5                  10

 tgc ttc cga tgc cac cat tgc aac agt aaa cta agt ttg gga aat tat     2377
 Cys Phe Arg Cys His His Cys Asn Ser Lys Leu Ser Leu Gly Asn Tyr
  15                  20                  25                  30

 gca tca ctt cat gga caa ata tac tgt aaa cct cac ttt aaa caa ctt     2425
 Ala Ser Leu His Gly Gln Ile Tyr Cys Lys Pro His Phe Lys Gln Leu
                  35                  40                  45

 ttc aaa tcc aaa gga aat tat gat gaa ggt ttt gga cat aag cag cat     2473
 Phe Lys Ser Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Lys Gln His
              50                  55                  60

 aaa gat aga tgg aac tgc aaa aac caa agc aga tca gtg gac ttt att     2521
 Lys Asp Arg Trp Asn Cys Lys Asn Gln Ser Arg Ser Val Asp Phe Ile
          65                  70                  75

 cct aat gaa gaa cca aat atg tgt aaa aat att gca gaa aac acc ctt     2569
 Pro Asn Glu Glu Pro Asn Met Cys Lys Asn Ile Ala Glu Asn Thr Leu
      80                  85                  90

 gta cct gga gat cgt aat gaa cat tta gat gct ggt aac agt gaa ggg     2617
 Val Pro Gly Asp Arg Asn Glu His Leu Asp Ala Gly Asn Ser Glu Gly
  95                 100                 105                 110

 caa agg aat gat ttg aga aaa tta ggg gaa agg gga aaa tta aaa gtc     2665
 Gln Arg Asn Asp Leu Arg Lys Leu Gly Glu Arg Gly Lys Leu Lys Val
                 115                 120                 125

 att tgg cct cct tcc aag gag atc cct aag aaa acc tta ccc ttt gag     2713
 Ile Trp Pro Pro Ser Lys Glu Ile Pro Lys Lys Thr Leu Pro Phe Glu
             130                 135                 140

 gaa gag ctc aaa atg agt aaa cct aag tgg cca cct gaa atg aca acc     2761
 Glu Glu Leu Lys Met Ser Lys Pro Lys Trp Pro Pro Glu Met Thr Thr
         145                 150                 155

 ctg cta tcc cct gaa ttt aaa agt gaa tct ctg cta gaa gat gtt aga     2809
 Leu Leu Ser Pro Glu Phe Lys Ser Glu Ser Leu Leu Glu Asp Val Arg
     160                 165                 170

 act cca gaa aat aaa gga caa aga caa gat cac ttt cca ttt ttg cag     2857
 Thr Pro Glu Asn Lys Gly Gln Arg Gln Asp His Phe Pro Phe Leu Gln
 175                 180                 185                 190

 cct tat cta cag tcc acc cat gtt tgt cag aaa gag gat gtt ata gga     2905
 Pro Tyr Leu Gln Ser Thr His Val Cys Gln Lys Glu Asp Val Ile Gly
                 195                 200                 205

 atc aaa gaa atg aaa atg cct gaa gga aga aaa gat gaa aag aag gaa     2953
 Ile Lys Glu Met Lys Met Pro Glu Gly Arg Lys Asp Glu Lys Lys Glu
             210                 215                 220

 gga agg aag aat gtg caa gat agg ccg agt gaa gct gaa gac aca aag     3001
 Gly Arg Lys Asn Val Gln Asp Arg Pro Ser Glu Ala Glu Asp Thr Lys
         225                 230                 235

 agt aac agg aaa agt gct atg gat ctt aat gac aac aat aat gtg att     3049
 Ser Asn Arg Lys Ser Ala Met Asp Leu Asn Asp Asn Asn Asn Val Ile
     240                 245                 250

 gtg cag agt gct gaa aag gag aaa aat gaa aaa act aac caa act aat     3097
 Val Gln Ser Ala Glu Lys Glu Lys Asn Glu Lys Thr Asn Gln Thr Asn
 255                 260                 265                 270

 ggt gca gaa gtt tta cag gtt act aac act gat gat gag atg atg cca     3145
 Gly Ala Glu Val Leu Gln Val Thr Asn Thr Asp Asp Glu Met Met Pro
                 275                 280                 285

 gaa aat cat aaa gaa aat ttg aat aag aat aat aat aac aat tat gta     3193
 Glu Asn His Lys Glu Asn Leu Asn Lys Asn Asn Asn Asn Asn Tyr Val
             290                 295                 300

 gca gtc tca tat ctg aat aat tgc agg cag aag aca tct att tta gaa     3241
 Ala Val Ser Tyr Leu Asn Asn Cys Arg Gln Lys Thr Ser Ile Leu Glu
         305                 310                 315

 ttt ctt gat cta tta ccc ttg tcg agt gaa gca aat gac act gca aat     3289
 Phe Leu Asp Leu Leu Pro Leu Ser Ser Glu Ala Asn Asp Thr Ala Asn
     320                 325                 330

 gaa tat gaa att gag aag tta gaa aat aca tct aga atc tca gag tta     3337
 Glu Tyr Glu Ile Glu Lys Leu Glu Asn Thr Ser Arg Ile Ser Glu Leu
 335                 340                 345                 350

 ctt ggt ata ttt gaa tct gaa aag act tat tcg agg aat gta cta gca     3385
 Leu Gly Ile Phe Glu Ser Glu Lys Thr Tyr Ser Arg Asn Val Leu Ala
                 355                 360                 365

 atg gct ctg aag aaa cag act gac aga gca gct gct ggc agt cct gtg     3433
 Met Ala Leu Lys Lys Gln Thr Asp Arg Ala Ala Ala Gly Ser Pro Val
             370                 375                 380

 cag cct gct cca aaa cca agc ctc agc aga ggc ctt atg gta aag ggg     3481
 Gln Pro Ala Pro Lys Pro Ser Leu Ser Arg Gly Leu Met Val Lys Gly
         385                 390                 395

 gga agt tca atc atc tct cct gat aca aat ctc tta aac att aaa gga     3529
 Gly Ser Ser Ile Ile Ser Pro Asp Thr Asn Leu Leu Asn Ile Lys Gly
     400                 405                 410

 agc cat tca aag agc aaa aat tta cac ttt ttc ttt tct aac acc gtg     3577
 Ser His Ser Lys Ser Lys Asn Leu His Phe Phe Phe Ser Asn Thr Val
 415                 420                 425                 430

 aaa atc act gca ttt tcc aag aaa aat gag aac att ttc aat tgt gat     3625
 Lys Ile Thr Ala Phe Ser Lys Lys Asn Glu Asn Ile Phe Asn Cys Asp
                 435                 440                 445

 tta ata gat tct gta gat caa att aaa aat atg cca tgc ttg gat tta     3673
 Leu Ile Asp Ser Val Asp Gln Ile Lys Asn Met Pro Cys Leu Asp Leu
             450                 455                 460

 agg gaa ttt gga aag gat gtt aaa cct tgg cat gtt gaa aca aca gaa     3721
 Arg Glu Phe Gly Lys Asp Val Lys Pro Trp His Val Glu Thr Thr Glu
         465                 470                 475

 gct gcc cgc aat aat gaa aac aca ggt ttt gat gct ctg agc cat gaa     3769
 Ala Ala Arg Asn Asn Glu Asn Thr Gly Phe Asp Ala Leu Ser His Glu
     480                 485                 490

 tgt aca gct aag cct ttg ttt ccc aga gtg gag gtg cag tca gaa caa     3817
 Cys Thr Ala Lys Pro Leu Phe Pro Arg Val Glu Val Gln Ser Glu Gln
 495                 500                 505                 510

 ctc acg gtg gaa gag cag att aaa aga aac agg tgc tac agt gac act     3865
 Leu Thr Val Glu Glu Gln Ile Lys Arg Asn Arg Cys Tyr Ser Asp Thr
                 515                 520                 525

 gag taa aatatctatg gccactgaca gtccacactt aggcactgag agatattgat      3921
 Glu 


 gttctgaaat aagattttat gaatttggat acccttttga ggaacttgat gtaaacatgg   3981

 tgttcagaaa tctcgtgtct atctcaatgg gatatttctt gtattacacc ttgtcatttt   4041

 tttcacaatt tatttacatc tacttttgtt tgaactggaa tgaagagatg aaacactatg   4101

 gatatgtttt ccattcaaat ggcactttag catattgttc tgttttcctg taaaacatca   4161

 tgggtgtgat ttttatactg ctgctgcttg tcacaattat tataacttct ctgtaatttc   4221

 ctctgaaata aaattgaatc acctgaggtg caaaccaaaa aaaaaaaa                4269




      <210> 216
      <211> 1975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (773)..(1831)

      <400> 216
 aaaagttagc tatatttata caaggaaaac caaaagaaat acttaaatga gacttttaaa     60

 attcgaggct ctccactgag acttgttccc tggcgccagc tccgggagtt ccgcagagcc    120

 tcgccccctg ccagggcgcc cggggcgaag gaccgcacgg cgcatgcgcg cctcctccag    180

 cagtcccttt ccccttcttc cccaagatcc agcgcgtgct cggttgccct tctccgttcc    240

 ttgcaggccc ttgggtcagg acccaccacc tgccggacca tcattttccg agtccctccg    300

 gcctagtcgg agtgctcgct cgcgcctcct aaagctctca gccgagcgcg ccgagacccc    360

 tcagggcggc cgcaattaat ggatgcctcg aagttgacgt acatatatat tcagaaatgt    420

 tttgccacct gagacctatg aggaggttat gtctagagaa gatatttcca cactggtttc    480

 ccttttcaag agctttatcg ggagctgaag cagtcaatgc cttgaggcct ttctattttg    540

 cagtacatcc agatttcttt ggacagcacc ccgtagaaag ggaaatcaat gaaaattctc    600

 ttaaaaggtt aagtgtctac ctagaaaacc tccagaaacc aggcttcaag tctttgaaac    660

 caactcagct tacattttat gtaagagaaa cagaccagag ttcctccgat ggccaggaac    720

 cttttagtac ttccgtttat ctgttgaaca tatccaaagc ttgaatacta at    atg     775
                                                              Met
                                                                1

 cat acc cag cct ctc aaa gaa gct aaa agg atg cct gac agg ccc atc      823
 His Thr Gln Pro Leu Lys Glu Ala Lys Arg Met Pro Asp Arg Pro Ile
               5                  10                  15

 aaa tgg gac aag tct tat tac tcc ttt act gga ttc aag gac cct gat      871
 Lys Trp Asp Lys Ser Tyr Tyr Ser Phe Thr Gly Phe Lys Asp Pro Asp
          20                  25                  30

 gaa gac ctt gaa caa gtc tcg aga gtg gaa aca act ctc aca tcc tgg      919
 Glu Asp Leu Glu Gln Val Ser Arg Val Glu Thr Thr Leu Thr Ser Trp
      35                  40                  45

 tta gat aac aat ggg aaa agt gct gtt aaa aag cta aag aac agt ttg      967
 Leu Asp Asn Asn Gly Lys Ser Ala Val Lys Lys Leu Lys Asn Ser Leu
  50                  55                  60                  65

 cca ctt aga aaa gaa cta gat cgt tta aaa gat gaa ctg tct cat caa     1015
 Pro Leu Arg Lys Glu Leu Asp Arg Leu Lys Asp Glu Leu Ser His Gln
                  70                  75                  80

 ttg caa ctc tca gat atc agg tgg cag agg agc tgg ggc atc gcc cac     1063
 Leu Gln Leu Ser Asp Ile Arg Trp Gln Arg Ser Trp Gly Ile Ala His
              85                  90                  95

 cgc tgt agc cag ctg cat agt tta agc cgc tta gca cag cag aat ttg     1111
 Arg Cys Ser Gln Leu His Ser Leu Ser Arg Leu Ala Gln Gln Asn Leu
         100                 105                 110

 gaa aca ctt aaa aaa gca aaa ggg tgt aca atc ata ttt aca gac cgt     1159
 Glu Thr Leu Lys Lys Ala Lys Gly Cys Thr Ile Ile Phe Thr Asp Arg
     115                 120                 125

 tct ggc atg agt gca gtg ggc cat gtg atg cta gga aca atg gat gtc     1207
 Ser Gly Met Ser Ala Val Gly His Val Met Leu Gly Thr Met Asp Val
 130                 135                 140                 145

 cat cac cac tgg aca aaa ctt ttt gaa aga ttg cca agt tat ttt gac     1255
 His His His Trp Thr Lys Leu Phe Glu Arg Leu Pro Ser Tyr Phe Asp
                 150                 155                 160

 ctt cag agg agg ctg atg att tta gaa gac caa ata agc tat ctt tta     1303
 Leu Gln Arg Arg Leu Met Ile Leu Glu Asp Gln Ile Ser Tyr Leu Leu
             165                 170                 175

 ggt ggc ata caa gtt gtt tat att gaa gaa tta cag cca gta ttg aca     1351
 Gly Gly Ile Gln Val Val Tyr Ile Glu Glu Leu Gln Pro Val Leu Thr
         180                 185                 190

 ctt gaa gaa tat tac tct ctt ctt gat gtg ttt tat aat aga ctg ttg     1399
 Leu Glu Glu Tyr Tyr Ser Leu Leu Asp Val Phe Tyr Asn Arg Leu Leu
     195                 200                 205

 aaa agt aga ata cta ttt cac cct cga agt ttg cgt ggt tta caa atg     1447
 Lys Ser Arg Ile Leu Phe His Pro Arg Ser Leu Arg Gly Leu Gln Met
 210                 215                 220                 225

 atc ctt aac agt gac aga tat gct cca agc ttg cat gaa ctc ggg cat     1495
 Ile Leu Asn Ser Asp Arg Tyr Ala Pro Ser Leu His Glu Leu Gly His
                 230                 235                 240

 ttt aat att cca aca ctc tgt gat cca gca aat ctc cag tgg ttt att     1543
 Phe Asn Ile Pro Thr Leu Cys Asp Pro Ala Asn Leu Gln Trp Phe Ile
             245                 250                 255

 ctc acc aaa gct cag cag gca aga gag aac atg aaa aga aag gaa gag     1591
 Leu Thr Lys Ala Gln Gln Ala Arg Glu Asn Met Lys Arg Lys Glu Glu
         260                 265                 270

 tta aag gtt att gaa aat gaa ttg ata cag gca tca aca aag aaa ttt     1639
 Leu Lys Val Ile Glu Asn Glu Leu Ile Gln Ala Ser Thr Lys Lys Phe
     275                 280                 285

 tct ttg gag aag tta tat aaa gag ccc agc att tct agt ata caa atg     1687
 Ser Leu Glu Lys Leu Tyr Lys Glu Pro Ser Ile Ser Ser Ile Gln Met
 290                 295                 300                 305

 gtg gat tgt tgt aag aga ctt cta gaa caa tca ctg cct tac cta cat     1735
 Val Asp Cys Cys Lys Arg Leu Leu Glu Gln Ser Leu Pro Tyr Leu His
                 310                 315                 320

 ggg atg cac ctc tgc att tca cat ttt tac tct gtt atg caa gat gga     1783
 Gly Met His Leu Cys Ile Ser His Phe Tyr Ser Val Met Gln Asp Gly
             325                 330                 335

 gac ctt tgt att cct tgg aat tgg aag aat gga gaa gcc att aag taa     1831
 Asp Leu Cys Ile Pro Trp Asn Trp Lys Asn Gly Glu Ala Ile Lys 
         340                 345                 350

 cacagaaatc tgttttattt ttttaagaga taagaaagga acttaaatta aaaatattta   1891

 aatccacaat ttgatataac agtattattt acataagaac aaagtttcta actgctgctt   1951

 taaaagtaga cttttttaaa aaaa                                          1975




      <210> 217
      <211> 426
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(296)

      <400> 217
 tgtacacatc gcaaagcgac atcccacgta tatgacatca catctgcaga gcattatacc     60

 gactccgagg ggacaacagg gggagcgaaa aaagcgcata caggacccta aacagaatcc    120

 tcact    atg gat ggg ctc att gag gac att aag cat cgg cgg tat tat     167
          Met Asp Gly Leu Ile Glu Asp Ile Lys His Arg Arg Tyr Tyr
            1               5                  10

 gag aag cca tgc cgc cgg cga cag agg gaa agc tat gaa agg tgc cgg      215
 Glu Lys Pro Cys Arg Arg Arg Gln Arg Glu Ser Tyr Glu Arg Cys Arg
  15                  20                  25                  30

 cgg atc tac aac atg gaa atg gct cgc aag atc aac ttc ttg atg cga      263
 Arg Ile Tyr Asn Met Glu Met Ala Arg Lys Ile Asn Phe Leu Met Arg
                  35                  40                  45

 aag aat cgg gca gat ccg tgg cag ggc tgc tga ggcctgtg ggtgggacac      314
 Lys Asn Arg Ala Asp Pro Trp Gln Gly Cys 
              50                  55

 ccagtgcgaa accctcatcc agttttctct ccatctcttt tctttgtaca atcccatttc    374

 ctattaccat tctctgcaat aaactcaaat cacatgtctg caaaaaaaaa aa            426




      <210> 218
      <211> 673
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(422)

      <400> 218
 gaccggctcc gcagcaagat ggcggacgag aaggacaggg aagagagatt ggaacaatta     60

 tcaggtcatt aggatgctgt cctacggaag gagagctgca tgatctgatt gcagaggtag    120

 aggaagaaga acccactgga tacattcgat tcgaaaaatt tcttccggtg   atg aca     176
                                                          Met Thr
                                                            1

 gaa ata cta cta gaa aga aaa tac aga cca att cca gaa gat gtc ctt      224
 Glu Ile Leu Leu Glu Arg Lys Tyr Arg Pro Ile Pro Glu Asp Val Leu
           5                  10                  15

 ctt cga gct ttt gag gtt tta gat tca gct aaa cgt ggg ttt ctt act      272
 Leu Arg Ala Phe Glu Val Leu Asp Ser Ala Lys Arg Gly Phe Leu Thr
      20                  25                  30

 aag gac gag ctg atc aag tat atg act gaa gaa ggt gag cct ttt tct      320
 Lys Asp Glu Leu Ile Lys Tyr Met Thr Glu Glu Gly Glu Pro Phe Ser
  35                  40                  45                  50

 caa gag gaa atg gaa gaa atg ttg tct gct gca att gat cca gaa tca      368
 Gln Glu Glu Met Glu Glu Met Leu Ser Ala Ala Ile Asp Pro Glu Ser
                  55                  60                  65

 aat tca att aat tac aag gac tat ata aca atg atg gtg ata gat gaa      416
 Asn Ser Ile Asn Tyr Lys Asp Tyr Ile Thr Met Met Val Ile Asp Glu
              70                  75                  80

 aat taa atgttctaaa gataatttct gattgaaaga acaattttag aaattgcttg       472
 Asn 


 ttcttgttaa tttcacatct tatcttagga ttcctatatg tgatatttaa taccttgtga    532

 cataactatt ttaagacact ttgtttttaa agatgatcgt aacactttaa accaaattta    592

 gtatgtctag ccttacagaa tgataaatta ctatttattt aaaaactatt cttaaaacat    652

 tttaacatta aaaaaaaaaa a                                              673




      <210> 219
      <211> 2349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(2105)

      <400> 219
 gtaccgctcc ggatttcccg ggtcgacgat ttcgtggg    atg gca aca gcc tcc      53
                                              Met Ala Thr Ala Ser
                                                1               5

 ggg gcc tcg gac ttg tct ggc tcc gga gcg ccc ccg ccc ggt gtg gga      101
 Gly Ala Ser Asp Leu Ser Gly Ser Gly Ala Pro Pro Pro Gly Val Gly
                  10                  15                  20

 gct cag gcg gcg gtg gcc gct gag gag gag gag cga gag gtg gtg cgg      149
 Ala Gln Ala Ala Val Ala Ala Glu Glu Glu Glu Arg Glu Val Val Arg
              25                  30                  35

 gtc cga gtc aag aaa tgt gag agc ttc ttg ccg cca gag ttc cgc tct      197
 Val Arg Val Lys Lys Cys Glu Ser Phe Leu Pro Pro Glu Phe Arg Ser
          40                  45                  50

 ttt gct gta gat ccc cag atc acc tcg ctc gac gtg ttg cag cac atc      245
 Phe Ala Val Asp Pro Gln Ile Thr Ser Leu Asp Val Leu Gln His Ile
      55                  60                  65

 ctc atc cga gcc ttt gat ttg agt ggg aag aag aac ttt ggc atc agc      293
 Leu Ile Arg Ala Phe Asp Leu Ser Gly Lys Lys Asn Phe Gly Ile Ser
  70                  75                  80                  85

 tac ctg ggc cgg gac cgg cta gga cag gaa gtt tac ctc tca ctt cta      341
 Tyr Leu Gly Arg Asp Arg Leu Gly Gln Glu Val Tyr Leu Ser Leu Leu
                  90                  95                 100

 tct gac tgg gac ctc agc aca gcc ttt gcc act gcc tcc aaa cct tac      389
 Ser Asp Trp Asp Leu Ser Thr Ala Phe Ala Thr Ala Ser Lys Pro Tyr
             105                 110                 115

 ctg caa ttg cgt gta gat att cgg ccc tcg gag gac agc cca ttg cta      437
 Leu Gln Leu Arg Val Asp Ile Arg Pro Ser Glu Asp Ser Pro Leu Leu
         120                 125                 130

 gaa gac tgg gac ata atc agc ccc aaa gat gtc att ggc tcc gac gtg      485
 Glu Asp Trp Asp Ile Ile Ser Pro Lys Asp Val Ile Gly Ser Asp Val
     135                 140                 145

 ttg ctg gct gag aaa cgg tca tca ctg acg act gcc gcc ctg ccc ttt      533
 Leu Leu Ala Glu Lys Arg Ser Ser Leu Thr Thr Ala Ala Leu Pro Phe
 150                 155                 160                 165

 aca cag tcc atc ctc act cag gtg ggc cgt acc ttg tct aag gtc caa      581
 Thr Gln Ser Ile Leu Thr Gln Val Gly Arg Thr Leu Ser Lys Val Gln
                 170                 175                 180

 caa gtg ctg agc tgg tcg tat ggg gaa gat gtc aag ccc ttc aag cca      629
 Gln Val Leu Ser Trp Ser Tyr Gly Glu Asp Val Lys Pro Phe Lys Pro
             185                 190                 195

 ccc ctg agc gat gct gag ttt cac acg tac ctg aac cac gag ggc cag      677
 Pro Leu Ser Asp Ala Glu Phe His Thr Tyr Leu Asn His Glu Gly Gln
         200                 205                 210

 ctc tcc cga ccc gag gag ttg cgc ctg cgg atc tat cat ggc ggt gtg      725
 Leu Ser Arg Pro Glu Glu Leu Arg Leu Arg Ile Tyr His Gly Gly Val
     215                 220                 225

 gag ccc tcg ctg cga aag gtg gtg tgg cgg tac ctg ctg aac gtg tat      773
 Glu Pro Ser Leu Arg Lys Val Val Trp Arg Tyr Leu Leu Asn Val Tyr
 230                 235                 240                 245

 cca gat gga ctg aca ggc cga gag cgg atg gac tac atg aaa cgc aag      821
 Pro Asp Gly Leu Thr Gly Arg Glu Arg Met Asp Tyr Met Lys Arg Lys
                 250                 255                 260

 agc cgc gag tat gag cag ctc aag agc gag tgg gcc cag cga gcg agc      869
 Ser Arg Glu Tyr Glu Gln Leu Lys Ser Glu Trp Ala Gln Arg Ala Ser
             265                 270                 275

 cct gag gac ctg gaa ttc atc cgc agc acg gtc ctc aag gat gta ctg      917
 Pro Glu Asp Leu Glu Phe Ile Arg Ser Thr Val Leu Lys Asp Val Leu
         280                 285                 290

 cgc act gac cgg gcc cac ccc tac tat gcg ggg cct gag gat ggc cca      965
 Arg Thr Asp Arg Ala His Pro Tyr Tyr Ala Gly Pro Glu Asp Gly Pro
     295                 300                 305

 cat cta cgg gcg ctg cac gac ctg ctc acc acc tat gcc gtt acc cac     1013
 His Leu Arg Ala Leu His Asp Leu Leu Thr Thr Tyr Ala Val Thr His
 310                 315                 320                 325

 cca cag gtg tcc tac tgc cag ggc atg agt gac ctt gcc tca ccc atc     1061
 Pro Gln Val Ser Tyr Cys Gln Gly Met Ser Asp Leu Ala Ser Pro Ile
                 330                 335                 340

 ctc gct gtc atg gac cat gag ggc cat gcc ttt gtt tgc ttt tgt ggc     1109
 Leu Ala Val Met Asp His Glu Gly His Ala Phe Val Cys Phe Cys Gly
             345                 350                 355

 atc atg aaa cgc ctg gcc gcc aac ttc cac cct gac ggc cgc gcc atg     1157
 Ile Met Lys Arg Leu Ala Ala Asn Phe His Pro Asp Gly Arg Ala Met
         360                 365                 370

 gcc acc aag ttt gca cac ttg aag ctg ttg ctg cga cac gct gac cct     1205
 Ala Thr Lys Phe Ala His Leu Lys Leu Leu Leu Arg His Ala Asp Pro
     375                 380                 385

 gac ttt tat caa tac ctg caa gag gca ggc gct gat gac ctc ttc ttc     1253
 Asp Phe Tyr Gln Tyr Leu Gln Glu Ala Gly Ala Asp Asp Leu Phe Phe
 390                 395                 400                 405

 tgt tac cgc tgg ctg ctg ctg gaa ctc aag cgt gag ttc gcc ttc gac     1301
 Cys Tyr Arg Trp Leu Leu Leu Glu Leu Lys Arg Glu Phe Ala Phe Asp
                 410                 415                 420

 gat gcc ctc cgc atg ctt gag gtc act tgg agt tcg ctg ccc cct gat     1349
 Asp Ala Leu Arg Met Leu Glu Val Thr Trp Ser Ser Leu Pro Pro Asp
             425                 430                 435

 cct cct gaa cat gag gta gag ctg gtt gga ccc ccc agc caa gtg gca     1397
 Pro Pro Glu His Glu Val Glu Leu Val Gly Pro Pro Ser Gln Val Ala
         440                 445                 450

 gac act ggt ttt ggt ggc cac agg ggg tgg ccc gtg cga cag agg cac     1445
 Asp Thr Gly Phe Gly Gly His Arg Gly Trp Pro Val Arg Gln Arg His
     455                 460                 465

 atg ctg agg cct gct ggt gga gga ggt agt acc ttt gaa gat gct gtt     1493
 Met Leu Arg Pro Ala Gly Gly Gly Gly Ser Thr Phe Glu Asp Ala Val
 470                 475                 480                 485

 gac cac ctg gcc aca gcc agt cag ggg cct ggt ggt ggg ggg cgt ctc     1541
 Asp His Leu Ala Thr Ala Ser Gln Gly Pro Gly Gly Gly Gly Arg Leu
                 490                 495                 500

 ctg aga cag gcc agc ttg gat ggc ctc cag caa ctc agg gat aac atg     1589
 Leu Arg Gln Ala Ser Leu Asp Gly Leu Gln Gln Leu Arg Asp Asn Met
             505                 510                 515

 ggc tcc agg agg gac cct ctg gtc cag ctg ccc cac cca gct gcc ctt     1637
 Gly Ser Arg Arg Asp Pro Leu Val Gln Leu Pro His Pro Ala Ala Leu
         520                 525                 530

 atc agc tcc aag tcc ctc tct gag cct tta ttg aac tcc cca gac cca     1685
 Ile Ser Ser Lys Ser Leu Ser Glu Pro Leu Leu Asn Ser Pro Asp Pro
     535                 540                 545

 ctg ctc tcc tcc ttt tcc cac cct gat tcc cca tct tcc tca tct cca     1733
 Leu Leu Ser Ser Phe Ser His Pro Asp Ser Pro Ser Ser Ser Ser Pro
 550                 555                 560                 565

 cca tcc acc cag gag gcc tct ccc act ggt gat atg gct gta gga tcc     1781
 Pro Ser Thr Gln Glu Ala Ser Pro Thr Gly Asp Met Ala Val Gly Ser
                 570                 575                 580

 ccc ttg atg caa gag gta ggc tcc ccg aaa gac cct gga aag tcc ctg     1829
 Pro Leu Met Gln Glu Val Gly Ser Pro Lys Asp Pro Gly Lys Ser Leu
             585                 590                 595

 cca cct gta cca cca atg ggc ctg ccc cca ccc cag gag ttt ggc cgg     1877
 Pro Pro Val Pro Pro Met Gly Leu Pro Pro Pro Gln Glu Phe Gly Arg
         600                 605                 610

 ggg aac cca ttc atg ctg ttc ctc tgc ctg gcc atc ctg ctg gag cac     1925
 Gly Asn Pro Phe Met Leu Phe Leu Cys Leu Ala Ile Leu Leu Glu His
     615                 620                 625

 cgc gac cac atc atg cgc aat ggg ctg gat tat aat gag ctg gcc atg     1973
 Arg Asp His Ile Met Arg Asn Gly Leu Asp Tyr Asn Glu Leu Ala Met
 630                 635                 640                 645

 cac ttt gac cgc ctt gtg cga aaa cac cac ctg ggg cgc gtc ctg cgc     2021
 His Phe Asp Arg Leu Val Arg Lys His His Leu Gly Arg Val Leu Arg
                 650                 655                 660

 cgg gct agg gct ctc ttt gct gat tac ctg cag tca gag gtg tgg gac     2069
 Arg Ala Arg Ala Leu Phe Ala Asp Tyr Leu Gln Ser Glu Val Trp Asp
             665                 670                 675

 tca gag gag ggg gct gag gcc aca gcc gca tct tga tcag gctttctcaa     2119
 Ser Glu Glu Gly Ala Glu Ala Thr Ala Ala Ser 
         680                 685

 gccctccatc ggccccacca gatctccatt ctttgccatg agggccaaca catgagaccc   2179

 cacctccctc cctgcctgcc agccctagac ttgttggagc atagagccct tcctccccag   2239

 gcctaagtat gtggagctct gctttggcac tgccccgcag aggccacgcc tatttattct   2299

 gtttctgttg ttttgttttt aacaactata ctttgcacaa aaaaaaaaaa              2349




      <210> 220
      <211> 1578
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(947)

      <400> 220
 aagatcccct aaaacatgct ggtgtctaca cggcagaaga agtggccctg att   atg      56
                                                              Met
                                                                1

 cgt gaa aag cta att cgt ttg cag tcg ttg tat att gat cag ttt aaa      104
 Arg Glu Lys Leu Ile Arg Leu Gln Ser Leu Tyr Ile Asp Gln Phe Lys
               5                  10                  15

 cga ctt cag cat ctg ctc aag gag aag aag cgc cga tac tta cat aat      152
 Arg Leu Gln His Leu Leu Lys Glu Lys Lys Arg Arg Tyr Leu His Asn
          20                  25                  30

 cgc aaa gtg gaa cat gaa gct cta ggc agt agt ctc ctg act ggc cca      200
 Arg Lys Val Glu His Glu Ala Leu Gly Ser Ser Leu Leu Thr Gly Pro
      35                  40                  45

 gag gga ctt ttg gcc aaa gaa cga gag aac tta aag cga tta aaa tgt      248
 Glu Gly Leu Leu Ala Lys Glu Arg Glu Asn Leu Lys Arg Leu Lys Cys
  50                  55                  60                  65

 ctg cga cga tac cgc cag cgc tat gga gtg gaa gcc tta ctg cat agg      296
 Leu Arg Arg Tyr Arg Gln Arg Tyr Gly Val Glu Ala Leu Leu His Arg
                  70                  75                  80

 cag ttg aag gaa cgg aga atg ctg gcc aca gat ggt gct gcc caa cag      344
 Gln Leu Lys Glu Arg Arg Met Leu Ala Thr Asp Gly Ala Ala Gln Gln
              85                  90                  95

 gcc cat acc act cgt tcc agt cag agg tgc ttg gcc ttt gtg gat gat      392
 Ala His Thr Thr Arg Ser Ser Gln Arg Cys Leu Ala Phe Val Asp Asp
         100                 105                 110

 gtt cgt tgt tcc aat cag tct ctt cca atg acc aga cac tgc ctt acc      440
 Val Arg Cys Ser Asn Gln Ser Leu Pro Met Thr Arg His Cys Leu Thr
     115                 120                 125

 cat att tgt cag gat acg aat cag gtt ctc ttc aag tgc tgc cag gga      488
 His Ile Cys Gln Asp Thr Asn Gln Val Leu Phe Lys Cys Cys Gln Gly
 130                 135                 140                 145

 tct gaa gag gta ccc tgc aac aaa cct gtt cct gta agc ctc tct gag      536
 Ser Glu Glu Val Pro Cys Asn Lys Pro Val Pro Val Ser Leu Ser Glu
                 150                 155                 160

 gat ccc tgc tgc cca ctg cat ttc cag ttg cct cct cag atg tat aag      584
 Asp Pro Cys Cys Pro Leu His Phe Gln Leu Pro Pro Gln Met Tyr Lys
             165                 170                 175

 ccc gag cag gta ctg tct gtg cca gac gat ctg gaa gcc ggc ccc atg      632
 Pro Glu Gln Val Leu Ser Val Pro Asp Asp Leu Glu Ala Gly Pro Met
         180                 185                 190

 gat ctg tac ttg agt gct gct gag ctt cag ccc act gag agt tta cct      680
 Asp Leu Tyr Leu Ser Ala Ala Glu Leu Gln Pro Thr Glu Ser Leu Pro
     195                 200                 205

 ctg gag ttc agt gat gac ttg gat gtt gtg ggt gat ggt atg cag tgt      728
 Leu Glu Phe Ser Asp Asp Leu Asp Val Val Gly Asp Gly Met Gln Cys
 210                 215                 220                 225

 cct cct tca cct ttg ctt ttt gat cct tca cta acc ctt gaa gat cat      776
 Pro Pro Ser Pro Leu Leu Phe Asp Pro Ser Leu Thr Leu Glu Asp His
                 230                 235                 240

 tta gtc aaa gaa att gct gaa gac cca gtg gat att ttg ggc cag atg      824
 Leu Val Lys Glu Ile Ala Glu Asp Pro Val Asp Ile Leu Gly Gln Met
             245                 250                 255

 cag atg gct gga gat ggg tgc aga tcc cag gga tct cga aat tct gag      872
 Gln Met Ala Gly Asp Gly Cys Arg Ser Gln Gly Ser Arg Asn Ser Glu
         260                 265                 270

 aaa gcc tct gca cca ttg tct cag agt gga ttg gct act gca aat ggg      920
 Lys Ala Ser Ala Pro Leu Ser Gln Ser Gly Leu Ala Thr Ala Asn Gly
     275                 280                 285

 aag cca gaa ccc act tct att agt tga tagtt tggggaacca ttttactttg      972
 Lys Pro Glu Pro Thr Ser Ile Ser 
 290                 295

 gtggatttaa atttctcgtt cttcaaagaa gtatttctga tcatctctca caaaacacag   1032

 gcaacccaga ctaccttgtt tttcttctgg attgagtatt atagtcaaac gtaaagccaa   1092

 attttgagga cgtggaccgt gggtttcttc ccactcaggg caaggaagag aaagagagat   1152

 aatccctatc aaagcttctg ggattatttg ggactatacc taaaaggaaa gtgacatctt   1212

 tgtaatggga tttcccaagt catggataga aatccactta agtagctagg tgggagctgt   1272

 ctttgtgagt ggtgtctttg agatactgat ggccctaata tcggttatct ctatctgaag   1332

 acctgcagtt tagcttttct tcacctctac ttaattgggc agtctttaac ccctttccct   1392

 ggtgaactct ggctttttat cctctgagaa aacagcccac aggactgggt cctccttatc   1452

 cgtcttgctt ttaacctatg taaatttctg tggttgctat cttatgtaaa atatagtaaa   1512

 aatttattgt atatagtttc tattaaatgt taaagaaaat gttatgaaaa tatcaaaaaa   1572

 aaaaaa                                                              1578




      <210> 221
      <211> 944
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(649)

      <400> 221
 atttggccct cgaggcccag aattccgcac gaggagcgat cgaggctgca acgcggccgc     60

 cgggcgcagc   atg act gcc gtc ggc gtg cag gcc cag agg cct ttg ggc     109
              Met Thr Ala Val Gly Val Gln Ala Gln Arg Pro Leu Gly
                1               5                  10

 caa agg cag ccc cgc cgg tcc ttc ttt gaa tcc ttc atc cgg acc ctc      157
 Gln Arg Gln Pro Arg Arg Ser Phe Phe Glu Ser Phe Ile Arg Thr Leu
      15                  20                  25

 atc atc acg tgt gtg gcc ctg gct gtg gtc ctg tcc tcg gtc tcc att      205
 Ile Ile Thr Cys Val Ala Leu Ala Val Val Leu Ser Ser Val Ser Ile
  30                  35                  40                  45

 tgt gat ggg cac tgg ctc ctg gct gag gac cgc ctc ttc ggg ctc tgg      253
 Cys Asp Gly His Trp Leu Leu Ala Glu Asp Arg Leu Phe Gly Leu Trp
                  50                  55                  60

 cac ttc tgc acc acc acc aac cag agt gtg ccg atc tgc ttc aga gac      301
 His Phe Cys Thr Thr Thr Asn Gln Ser Val Pro Ile Cys Phe Arg Asp
              65                  70                  75

 ctg ggc cag gcc cat gtg ccc ggg ctg gcc gtg ggc atg ggc ctg gta      349
 Leu Gly Gln Ala His Val Pro Gly Leu Ala Val Gly Met Gly Leu Val
          80                  85                  90

 cgc agc gtg ggc gcc ttg gcc gtg gtg gcc gcc att ttt ggc ctg gag      397
 Arg Ser Val Gly Ala Leu Ala Val Val Ala Ala Ile Phe Gly Leu Glu
      95                 100                 105

 ttc ctc atg gtg tcc cag ttg tgc gag gac aaa cac tca cag tgc aag      445
 Phe Leu Met Val Ser Gln Leu Cys Glu Asp Lys His Ser Gln Cys Lys
 110                 115                 120                 125

 tgg gtc atg ggt tcc atc ctc ctc ctg gtg tct ttc gtc ctc tcc tcc      493
 Trp Val Met Gly Ser Ile Leu Leu Leu Val Ser Phe Val Leu Ser Ser
                 130                 135                 140

 ggc ggg ctc ctg ggt ttt gtg atc ctc ctc agg aac caa gtc aca ctc      541
 Gly Gly Leu Leu Gly Phe Val Ile Leu Leu Arg Asn Gln Val Thr Leu
             145                 150                 155

 atc ggc ttc acc cta atg ttt tgg tgc gaa ttc act gcc tcc ttc ctc      589
 Ile Gly Phe Thr Leu Met Phe Trp Cys Glu Phe Thr Ala Ser Phe Leu
         160                 165                 170

 ctc ttc ctg aac gcc atc agc ggc ctt cac atc aac agc atc acc cat      637
 Leu Phe Leu Asn Ala Ile Ser Gly Leu His Ile Asn Ser Ile Thr His
     175                 180                 185

 ccc tgg gaa tga ccg tggaaatttt aggccccctc cagggacatc agattccaca      692
 Pro Trp Glu 
 190

 agaaaatatg gtcaaaatgg gacttttcca gcatgtggcc tctggtgggg ctgggttgga    752

 caagggcctt gaaacggctg cctgtttgcc gataacttgt gggtggtcag ccagaaatgg    812

 ccggggggcc tctgcacctg gtctgcaggg ccagaggcca ggagggtgcc tcagtgccac    872

 caactgcaca ggcttagcca gatgttgatt ttagaggaag aaaaaaacat tttaaaactc    932

 aaaaaaaaaa aa                                                        944




      <210> 222
      <211> 1105
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (570)..(1055)

      <400> 222
 ccacgctcaa cctttggccc agccatcgcc gagattcgag ggtcaactgg aagtggcgtt     60

 ggtgctccct gtggacttgc gtcggcaccc agaggccttg gagggacaag gcactgggcg    120

 gtgtgactgg tcatggcact tgctggcctt ctggccagag gtcctcctgg aagcccctcc    180

 tttcagtgcc tggctgcagc ggtgctagcc aggctggagt ccagcacctc tcgccggtgt    240

 ctgtgtgagt gagcgcatgt gcgcatttat gagcatctac ttgcggctgc actcagggcc    300

 atttgaaccc agtgcagagt tatctctatg aggaggcccc gggtctccag ccccctccat    360

 ctcccctggg gtttggcata tttgacatgg agccccatgc caagggatgc agctgttggt    420

 gtctgtccag tccattcaag gctagcctgc ccatgcactg tggcaggggt tggattggag    480

 ggagagaaca gagttgggaa aaacaacagg tttgagtcct ataaagccat aatttaactc    540

 cagtagctga tgtcagacaa gcttgtcct  atg tcc tat ttg agt ggc agc agc     593
                                  Met Ser Tyr Leu Ser Gly Ser Ser
                                    1               5

 gcc agc cca gca aga agg ctg ggg gtt gtc aag gtt gtc ccc aga cct      641
 Ala Ser Pro Ala Arg Arg Leu Gly Val Val Lys Val Val Pro Arg Pro
      10                  15                  20

 tgc ttg cag tgg ttg gag aac cca ggg ggc tgc ctt ggg ccc tct ggc      689
 Cys Leu Gln Trp Leu Glu Asn Pro Gly Gly Cys Leu Gly Pro Ser Gly
  25                  30                  35                  40

 cag agg gaa gcg ggc agc tct agc cct gga gat tgt ggt cac att ggg      737
 Gln Arg Glu Ala Gly Ser Ser Ser Pro Gly Asp Cys Gly His Ile Gly
                  45                  50                  55

 gct tgt tta gga ttg gag ggc cag gtc acc tcc cca gcc acc ctc cct      785
 Ala Cys Leu Gly Leu Glu Gly Gln Val Thr Ser Pro Ala Thr Leu Pro
              60                  65                  70

 tct ctc ctc tgg ggt ccc cac ttt agg gcg act ttg ccc gag gcc cac      833
 Ser Leu Leu Trp Gly Pro His Phe Arg Ala Thr Leu Pro Glu Ala His
          75                  80                  85

 gca tcc atc cac tcc ttt agt gcc ttg aat ctc att cac aag cag ccc      881
 Ala Ser Ile His Ser Phe Ser Ala Leu Asn Leu Ile His Lys Gln Pro
      90                  95                 100

 cct ccc ttc ccc tcc cct tct cac tct gtt gat gta atc ctc cca ccc      929
 Pro Pro Phe Pro Ser Pro Ser His Ser Val Asp Val Ile Leu Pro Pro
 105                 110                 115                 120

 cca gtg tcc atc cta aga cag gca tca aaa gag gcc cta act tta ctt      977
 Pro Val Ser Ile Leu Arg Gln Ala Ser Lys Glu Ala Leu Thr Leu Leu
                 125                 130                 135

 ccc aaa tgg tgc ttt tta aaa aac acc atc act aca tta ggg gca att     1025
 Pro Lys Trp Cys Phe Leu Lys Asn Thr Ile Thr Thr Leu Gly Ala Ile
             140                 145                 150

 ttt tca cac ctc cct gtc ttc aga atg taa a gggtggggat tatgtctctg     1076
 Phe Ser His Leu Pro Val Phe Arg Met 
         155                 160

 tttaatatgc agccccctgc actgtgggg                                     1105




      <210> 223
      <211> 1219
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1059)

      <400> 223
 aattcccggg tcgacccacg cgtccgcagg taccccgccg cctccctcct tcccgcagga     60

 ctcgtgcctc ctggccctgg gccccaacgg tgcccgcctg cccggcggac ggtcagcgca    120

 cagggcacgg cttcctctgc ttctctcgga ccacttagtc tcaacccgga atgaaat       177                                                                 
 atg act gag gac tct cag aga aac ttt cgt tca gta tat tat gag aaa      225
 Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys
   1               5                  10                  15

 gtg ggg ttt cgt gga gtt gaa gaa aag aaa tca tta gaa att ctc cta      273
 Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu
              20                  25                  30

 aaa gat gac cgt ctg gat act gag aaa ctt tgt act ttt agt cag agg      321
 Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg
          35                  40                  45

 ttc cct ctc ccg tcc atg tac cgt gca ttg gta tgg aag gtg ctt cta      369
 Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu
      50                  55                  60

 gga atc ttg cct cca cac cac gag tcc cat gcc aag gtg atg atg tat      417
 Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr
  65                  70                  75                  80

 cgt aag gag cag tac ttg gat gtc ctt cat gcc ctg aaa gtc gtt cgc      465
 Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg
                  85                  90                  95

 ttt gtt agt gat gcc aca cct cag gct gaa gtc tat ctc cgc atg tat      513
 Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr
             100                 105                 110

 cag ctg gag tct ggg aag tta cct cga agt ccc tct ttt cca ctg gag      561
 Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu
         115                 120                 125

 cca gat gat gaa gtg ttt ctt gcc ata gct aaa gcc atg gag gaa atg      609
 Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met
     130                 135                 140

 gtg gaa gat agt gtc gac tgt tac tgg atc acc cga cgc ttt gtg aac      657
 Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn
 145                 150                 155                 160

 caa tta aat acc aag tac cgg gat tcc ttg ccc cag ttg cca aaa gcg      705
 Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala
                 165                 170                 175

 ttt gaa caa tac ttg aat ctg gaa gat ggc aga ctg ctg act cat ctg      753
 Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu
             180                 185                 190

 agg atg tgt tcc gcg gcg ccc aaa ctt cct tat gat ctc tgg ttc aag      801
 Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys
         195                 200                 205

 agg tgc ttt gcg gga tgt ttg cct gaa tcc agt tta cag agg gtt tgg      849
 Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp
     210                 215                 220

 gat aaa gtt gtg agt gga tcc tgt aag atc cta gtt ttt gta gct gtc      897
 Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val
 225                 230                 235                 240

 gaa att tta tta acc ttt aaa ata aaa gtt atg gca ctg aac agt gca      945
 Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala
                 245                 250                 255

 gag aag ata aca aag ttt ctg gaa aat att ccc cag gac agc tca gac      993
 Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp
             260                 265                 270

 gcg atc gtg agc aag gcc att gac ttg tgg cac aaa cac tgt ggg acc     1041
 Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr
         275                 280                 285

 ccg gtc cat tca agc tga acgcac ccgctggttg tggaccgtct gccaggcacc     1095
 Pro Val His Ser Ser 
     290

 acagtgagca ttgtgttctt ggcatgtgat ctgggaaact gattgaataa tacacttttc   1155

 ttgctttggt gctcaaagtg gtttttttcc cccaataaaa ttatttaatt gaaaaaaaaa   1215

 aaaa                                                                1219




      <210> 224
      <211> 1138
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(978)

      <400> 224
 aattcccggg tcgacccacg cgtccgcagg taccccgccg cctccctcct tcccgcagga     60

 ctcgtgcctc ctggccctgg gccccaacgg tgcccgcctg cccggcggac ggtcagcgca    120

 cagggcacgg cttcctctgc ttctctcgga ccacttagtc tcaacccgga atgaaat       177                                                                 
 atg act gag gac tct cag aga aac ttt cgt tca gta tat tat gag aaa      225
 Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys
   1               5                  10                  15

 gtg ggg ttt cgt gga gtt gaa gaa aag aaa tca tta gaa att ctc cta      273
 Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu
              20                  25                  30

 aaa gat gac cgt ctg gga atc ttg cct cca cac cac gag tcc cat gcc      321
 Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala
          35                  40                  45

 aag gtg atg atg tat cgt aag gag cag tac ttg gat gtc ctt cat gcc      369
 Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala
      50                  55                  60

 ctg aaa gtc gtt cgc ttt gtt agt gat gcc aca cct cag gct gaa gtc      417
 Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val
  65                  70                  75                  80

 tat ctc cgc atg tat cag ctg gag tct ggg aag tta cct cga agt ccc      465
 Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro
                  85                  90                  95

 tct ttt cca ctg gag cca gat gat gaa gtg ttt ctt gcc ata gct aaa      513
 Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys
             100                 105                 110

 gcc atg gag gaa atg gtg gaa gat agt gtc gac tgt tac tgg atc acc      561
 Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr
         115                 120                 125

 cga cgc ttt gtg aac caa tta aat acc aag tac cgg gat tcc ttg ccc      609
 Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro
     130                 135                 140

 cag ttg cca aaa gcg ttt gaa caa tac ttg aat ctg gaa gat ggc aga      657
 Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg
 145                 150                 155                 160

 ctg ctg act cat ctg agg atg tgt tcc gcg gcg ccc aaa ctt cct tat      705
 Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr
                 165                 170                 175

 gat ctc tgg ttc aag agg tgc ttt gcg gga tgt ttg cct gaa tcc agt      753
 Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser
             180                 185                 190

 tta cag agg gtt tgg gat aaa gtt gtg agt gga tcc tgt aag atc cta      801
 Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu
         195                 200                 205

 gtt ttt gta gct gtc gaa att tta tta acc ttt aaa ata aaa gtt atg      849
 Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met
     210                 215                 220

 gca ctg aac agt gca gag aag ata aca aag ttt ctg gaa aat att ccc      897
 Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro
 225                 230                 235                 240

 cag gac agc tca gac gcg atc gtg agc aag gcc att gac ttg tgg cac      945
 Gln Asp Ser Ser Asp Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His
                 245                 250                 255

 aaa cac tgt ggg acc ccg gtc cat tca agc tga acgcaccc gctggttgtg      996
 Lys His Cys Gly Thr Pro Val His Ser Ser 
             260                 265

 gaccgtctgc caggcaccac agtgagcatt gtgttcttgg catgtgatct gggaaactga   1056

 ttgaataata cacttttctt gctttggtgc tcaaagtggt ttttttcccc caataaaatt   1116

 atttaattga aaaaaaaaaa aa                                            1138




      <210> 225
      <211> 2343
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (669)..(1661)

      <400> 225
 agcttaacaa gaccatggcc tctggacccg cgatcagctc gctgtgtggt cctgagcagc     60

 cacccaacat ctctgggcct tggattccta cctggccttt cttctggatg catcattttt    120

 gcctttaggt atctggacca ttccccccca tggatgataa agtctttgct tcacaccctc    180

 aggattacct taaaggcctg aaaagaacag aggaggagtc tgaggaggtg aattccagcc    240

 gtgctcttgc aggctggctg ggcagtgtgc tggggaggag agggagcctc tggctgggcc    300

 tcctccaccg ggcctggtgt gctgggaaca ccccgcattg tcccaaggcc tcagatttga    360

 ctttcaaagg gaaaacagct ctcctgataa aggacaccat tggagaaact gggcatttta    420

 ccaaggattt gactggaatg gcatgcttcc tttaaagatg aaagttgact tttagagcca    480

 attaaagccc tttggggaat ctggcctcat accttgtcca cacagagttc ctgtacaagg    540

 ttcctgacct gtgggaagcg gcacagcacc agctaggcag agacgcccca ggccatgtta    600

 gagctttgag tgaggcctgg taacagggag gcgctgtcac ctactggcct tgccaatcca    660

 gctccaag atg ctg agc ctg aag ctc ccc agg ctg ttt agc ata gac cag     710
          Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln
            1               5                  10

 ata ccc cag gtg ttc cat gag caa ggc atc ctg ttc ggc tac cgc cat      758
 Ile Pro Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His
  15                  20                  25                  30

 cca cag agt tct gcc act gcc tgc atc ctc agc ctt ttc caa atg acc      806
 Pro Gln Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr
                  35                  40                  45

 aat gag act ctc aac att tgg act cac ttg ctg ccc ttc tgg ttc ttt      854
 Asn Glu Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe
              50                  55                  60

 gca tgg agg ttt gtg act gca ctg tat atg aca gac atc aag aat gac      902
 Ala Trp Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp
          65                  70                  75

 agc tac tcc tgg ccc atg ctt gtg tac atg tgc acc agc tgc gtg tac      950
 Ser Tyr Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr
      80                  85                  90

 cca ctt gtg tcc agc tgt gcg cac acc ttc agc tct atg tcc aag aat      998
 Pro Leu Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn
  95                 100                 105                 110

 gcc cgg cac att tgc tac ttc ctg gac tat ggt gcc gtc aac ctc ttc     1046
 Ala Arg His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe
                 115                 120                 125

 agc ctg ggc tca gcc att gcc tac tct gca tac acg ttc ccg gat gcg     1094
 Ser Leu Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala
             130                 135                 140

 ctc atg tgc acc act ttc cat gac tac tac gtg gcc ctg gct gta ctg     1142
 Leu Met Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu
         145                 150                 155

 aac acc atc ctc agc aca ggc ctc tcc tgc tac tcc agg ttt ctt gaa     1190
 Asn Thr Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu
     160                 165                 170

 gtc cag aag ccc aga ctc tgt aag gtg att cgt gtc ctc gcc ttt gct     1238
 Val Gln Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala
 175                 180                 185                 190

 tat ccg tac acc tgg gac tcc ctc ccc atc ttc tac agg cta ttc ctg     1286
 Tyr Pro Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu
                 195                 200                 205

 ttc cca ggg gag agt gca caa aat gaa gcc acc tcg tac cac cag aag     1334
 Phe Pro Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys
             210                 215                 220

 cac atg atc atg acc ctc ctg gcc tct ttc ttg tac tct gca cat ctg     1382
 His Met Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu
         225                 230                 235

 cca gaa cgc cta gcc cct gga cgc ttt gac tac atc ggt cac agt cac     1430
 Pro Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His
     240                 245                 250

 cag ctg ttt cac gtg tgt gtg atc ctg gcc acg cac atg cag atg gaa     1478
 Gln Leu Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu
 255                 260                 265                 270

 gcc ata ctt ctg gac aag act ctg agg aag gaa tgg ctc ctg gcc acc     1526
 Ala Ile Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr
                 275                 280                 285

 tcc aag ccc ttc tct ttc tct cag ata gct gga gcc ata ctt ctg tgc     1574
 Ser Lys Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys
             290                 295                 300

 atc atc ttc agc ctc agc aac ata att tat ttc tca gct gct ctg tat     1622
 Ile Ile Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr
         305                 310                 315

 cgg att ccc aag cca gaa tta cat aaa aaa gaa aca tga ctcagaccat      1671
 Arg Ile Pro Lys Pro Glu Leu His Lys Lys Glu Thr 
     320                 325                 330

 aagcttttca tgccagatgt caacattaag ctgcaacatc ctaaccacca taagccggag   1731

 gtggttacag cttatcacgg cctaaaatat tcataatggt tggtgtcttt tgaatgaatt   1791

 catgtcaaaa atgttattca gctggggaaa tttctctaaa tgtacactga ttctgtgtgt   1851

 gtgattttaa aaggagaaca tggttcaagc aagtccttgt taaggcaaac tattgatatt   1911

 tcattaattt taaatttact taaaatgtgg ttttaaattc tatttaaaca tttggattaa   1971

 gcatattact ctggagcttt gtattattct ttaaaaatga atcttgcttc atttgatgaa   2031

 tttcatgtca caaagcttct ctcaagagct ctcgtagtgg cctgtcaacc actttcggag   2091

 aatgagccag gtcagtcact gggaggacct gtgaaagaaa gttggtcact gagtgccttg   2151

 gggactggca aaacattcca gaatgaagag agctgtctgg ggagagccct tcttcccttc   2211

 tccacctagt gaagggagaa cagaagggga gtcctctctt cccacaagtc cattctgcct   2271

 tcaaagtgta agttctcatg tcattatgga tttggagttt gtcagttttt ttcttaaaag   2331

 tccacagcgg gg                                                       2343




      <210> 226
      <211> 2255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(1539)

      <400> 226
 atagaaccct gtggtaccgt tccggacttc ccgggtcgac ccacgcgtcc gcccacgcgt     60

 ccggagcggt ggaggcggat ttcctgggcc cggccctctg gcgctacc atg gcg ttt     117
                                                      Met Ala Phe
                                                        1

 ggc aag agt cac cgg gat ccc tac gcg acc tcc gtg ggc cac ctc ata      165
 Gly Lys Ser His Arg Asp Pro Tyr Ala Thr Ser Val Gly His Leu Ile
       5                  10                  15

 gaa aag gct aca ttt gct gga gtt cag act gaa gat tgg ggc cag ttc      213
 Glu Lys Ala Thr Phe Ala Gly Val Gln Thr Glu Asp Trp Gly Gln Phe
  20                  25                  30                  35

 atg cac atc tgt gac ata att aac act acc cag gat ggg cca aaa gat      261
 Met His Ile Cys Asp Ile Ile Asn Thr Thr Gln Asp Gly Pro Lys Asp
                  40                  45                  50

 gca gtg aaa gct ttg aag aaa agg att tcc aaa aac tac aat cat aaa      309
 Ala Val Lys Ala Leu Lys Lys Arg Ile Ser Lys Asn Tyr Asn His Lys
              55                  60                  65

 gaa atc caa ctt acc ttg tca ctt att gac atg tgt gtg cag aac tgt      357
 Glu Ile Gln Leu Thr Leu Ser Leu Ile Asp Met Cys Val Gln Asn Cys
          70                  75                  80

 ggt cca agt ttc cag tct ctg att gtg aag aag gaa ttt gtt aaa gag      405
 Gly Pro Ser Phe Gln Ser Leu Ile Val Lys Lys Glu Phe Val Lys Glu
      85                  90                  95

 aat tta gtt aag cta ctg aat ccc aga tac aac ttg cca tta gac att      453
 Asn Leu Val Lys Leu Leu Asn Pro Arg Tyr Asn Leu Pro Leu Asp Ile
 100                 105                 110                 115

 cag aat aga atc ttg aat ttc att aag act tgg tca cag ggc ttc cca      501
 Gln Asn Arg Ile Leu Asn Phe Ile Lys Thr Trp Ser Gln Gly Phe Pro
                 120                 125                 130

 gga ggt gtg gat gta agc gaa gtc aaa gaa gta tac ctc gac ctg gtt      549
 Gly Gly Val Asp Val Ser Glu Val Lys Glu Val Tyr Leu Asp Leu Val
             135                 140                 145

 aag aaa ggc gtt cag ttt cct ccc tca gaa gca gag gct gaa aca gca      597
 Lys Lys Gly Val Gln Phe Pro Pro Ser Glu Ala Glu Ala Glu Thr Ala
         150                 155                 160

 aga caa gag act gct caa atc tca tca aat cct cca aca tct gtc cct      645
 Arg Gln Glu Thr Ala Gln Ile Ser Ser Asn Pro Pro Thr Ser Val Pro
     165                 170                 175

 act gca cca gct ctt tct tct gta att gct cca aag aac tcg act gtt      693
 Thr Ala Pro Ala Leu Ser Ser Val Ile Ala Pro Lys Asn Ser Thr Val
 180                 185                 190                 195

 aca ttg gtc cca gaa cag att gga aaa ctg cac agt gaa ttg gat atg      741
 Thr Leu Val Pro Glu Gln Ile Gly Lys Leu His Ser Glu Leu Asp Met
                 200                 205                 210

 gtg aaa atg aat gtg cga gtg atg tcc gcc ata ttg atg gag aat act      789
 Val Lys Met Asn Val Arg Val Met Ser Ala Ile Leu Met Glu Asn Thr
             215                 220                 225

 cct ggg tct gaa aac cat gaa gac ata gag ctt ctg cag aaa ctc tat      837
 Pro Gly Ser Glu Asn His Glu Asp Ile Glu Leu Leu Gln Lys Leu Tyr
         230                 235                 240

 aaa aca ggt cgg gag atg cag gag agg atc atg gac ctg ctt gtg gtg      885
 Lys Thr Gly Arg Glu Met Gln Glu Arg Ile Met Asp Leu Leu Val Val
     245                 250                 255

 gtg gag aac gaa gat gta act gtt gag cta att cag gtg aat gag gat      933
 Val Glu Asn Glu Asp Val Thr Val Glu Leu Ile Gln Val Asn Glu Asp
 260                 265                 270                 275

 ttg aat aat gct atc ctt gga tat gag agg ttt act aga aac caa caa      981
 Leu Asn Asn Ala Ile Leu Gly Tyr Glu Arg Phe Thr Arg Asn Gln Gln
                 280                 285                 290

 agg att ttg gag caa aat aag aac cag aag gaa gcc acc aat act acc     1029
 Arg Ile Leu Glu Gln Asn Lys Asn Gln Lys Glu Ala Thr Asn Thr Thr
             295                 300                 305

 agt gag cct tct gcc cca tct caa gat ctc ctc gac cta agt ccc agt     1077
 Ser Glu Pro Ser Ala Pro Ser Gln Asp Leu Leu Asp Leu Ser Pro Ser
         310                 315                 320

 ccc cgg atg cct agg gcc act ctg gga gaa ctc aac acc atg aat aat     1125
 Pro Arg Met Pro Arg Ala Thr Leu Gly Glu Leu Asn Thr Met Asn Asn
     325                 330                 335

 caa ctt tca ggc tta aat ttc agc ctt cca agt tct gat gta aca aac     1173
 Gln Leu Ser Gly Leu Asn Phe Ser Leu Pro Ser Ser Asp Val Thr Asn
 340                 345                 350                 355

 aac tta aaa ccc agt ctt cat cca cag atg aac ttg cta gcc ttg gag     1221
 Asn Leu Lys Pro Ser Leu His Pro Gln Met Asn Leu Leu Ala Leu Glu
                 360                 365                 370

 aat aca gag ata ccc ccg ttt gcc caa agg acc agc caa aac ctc acc     1269
 Asn Thr Glu Ile Pro Pro Phe Ala Gln Arg Thr Ser Gln Asn Leu Thr
             375                 380                 385

 tca agc cac gca tat gat aat ttt ctg gaa cat tca aat tca gtg ttt     1317
 Ser Ser His Ala Tyr Asp Asn Phe Leu Glu His Ser Asn Ser Val Phe
         390                 395                 400

 cta cag cca gtt agt cta caa acc att gca gca gca cca tca aac cag     1365
 Leu Gln Pro Val Ser Leu Gln Thr Ile Ala Ala Ala Pro Ser Asn Gln
     405                 410                 415

 agt ctg cca cct ttg ccc agc aat cat cca gcg atg aca aaa agt gat     1413
 Ser Leu Pro Pro Leu Pro Ser Asn His Pro Ala Met Thr Lys Ser Asp
 420                 425                 430                 435

 ctc cag cca cct aat tac tac gag gta atg gag ttt gat ccc tta gct     1461
 Leu Gln Pro Pro Asn Tyr Tyr Glu Val Met Glu Phe Asp Pro Leu Ala
                 440                 445                 450

 cct gct gtc act aca gaa gct att tat gaa gaa att gat gct cac cag     1509
 Pro Ala Val Thr Thr Glu Ala Ile Tyr Glu Glu Ile Asp Ala His Gln
             455                 460                 465

 cac aaa gga gct caa aat gat ggt gac tga g aagaaagtgg atgatcagct     1560
 His Lys Gly Ala Gln Asn Asp Gly Asp 
         470                 475

 cactaccaca tcaaaggtgc caactctcta aaacgtagac tctgtgcagc tttgaagcct   1620

 ggaagacaat acctaccaac atgtcaaagc catggtggca catttctgct ataatgaaga   1680

 ttaaatagaa taacagttcc aggataacac tgattcctga caacagcgtg agatttcaac   1740

 agaacttgtt tggaacaaat actcacttaa aacttcagca gaagaaaaat tacttagtcc   1800

 ttaggccaac caatttaact gcagtgtcat gtttcacagg ccttcctaca tttagaaatc   1860

 gtcacacagc tgtgataaga gtagattatt ttactatgaa ataattctga atagatgaaa   1920

 gcataaaatg tgagaaactg aatgtattat tcaggaagaa tactgagtgc cttcatttaa   1980

 ctaaagttga atgtaaaagt caatttgcac ttctttataa tcctctggtt tagaattata   2040

 aattgttaaa accttgataa ttgtcattta attatatttc aggtgtcctg aacaggtcac   2100

 tagactctac attgggcagc ctttaaatat gattctttgt aatgctaaat agcctttttt   2160

 tctcttttta ctgcaactta atatttctat ttagaacaca gaaaatgaaa atatttagaa   2220

 taagttgtac atttgatgac aaataaatca ctatt                              2255




      <210> 227
      <211> 1757
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(1041)

      <400> 227
 atagaaccct gtggtaccgt tccggacttc ccgggtcgac ccacgcgtcc gcccacgcgt     60

 ccggagcggt ggaggcggat ttcctgggcc cggccctctg gcgctacc atg gcg ttt     117
                                                      Met Ala Phe
                                                        1

 ggc aag agt cac cgg gat ccc tac gcg acc tcc gtg ggc cac ctc ata      165
 Gly Lys Ser His Arg Asp Pro Tyr Ala Thr Ser Val Gly His Leu Ile
       5                  10                  15

 gaa aag gct aca ttt gct gga gtt cag act gaa gat tgg ggc cag ttc      213
 Glu Lys Ala Thr Phe Ala Gly Val Gln Thr Glu Asp Trp Gly Gln Phe
  20                  25                  30                  35

 atg cac atc tgt gac ata att aac act acc cag gat ggg cca aaa gat      261
 Met His Ile Cys Asp Ile Ile Asn Thr Thr Gln Asp Gly Pro Lys Asp
                  40                  45                  50

 gca gtg aaa gct ttg aag aaa agg att tcc aaa aac tac aat cat aaa      309
 Ala Val Lys Ala Leu Lys Lys Arg Ile Ser Lys Asn Tyr Asn His Lys
              55                  60                  65

 gaa atc caa ctt acc ttg tca aaa ctc tat aaa aca ggt cgg gag atg      357
 Glu Ile Gln Leu Thr Leu Ser Lys Leu Tyr Lys Thr Gly Arg Glu Met
          70                  75                  80

 cag gag agg atc atg gac ctg ctt gtg gtg gtg gag aac gaa gat gta      405
 Gln Glu Arg Ile Met Asp Leu Leu Val Val Val Glu Asn Glu Asp Val
      85                  90                  95

 act gtt gag cta att cag gtg aat gag gat ttg aat aat gct atc ctt      453
 Thr Val Glu Leu Ile Gln Val Asn Glu Asp Leu Asn Asn Ala Ile Leu
 100                 105                 110                 115

 gga tat gag agg ttt act aga aac caa caa agg att ttg gag caa aat      501
 Gly Tyr Glu Arg Phe Thr Arg Asn Gln Gln Arg Ile Leu Glu Gln Asn
                 120                 125                 130

 aag aac cag aag gaa gcc acc aat act acc agt gag cct tct gcc cca      549
 Lys Asn Gln Lys Glu Ala Thr Asn Thr Thr Ser Glu Pro Ser Ala Pro
             135                 140                 145

 tct caa gat ctc ctc gac cta agt ccc agt ccc cgg atg cct agg gcc      597
 Ser Gln Asp Leu Leu Asp Leu Ser Pro Ser Pro Arg Met Pro Arg Ala
         150                 155                 160

 act ctg gga gaa ctc aac acc atg aat aat caa ctt tca ggc tta aat      645
 Thr Leu Gly Glu Leu Asn Thr Met Asn Asn Gln Leu Ser Gly Leu Asn
     165                 170                 175

 ttc agc ctt cca agt tct gat gta aca aac aac tta aaa ccc agt ctt      693
 Phe Ser Leu Pro Ser Ser Asp Val Thr Asn Asn Leu Lys Pro Ser Leu
 180                 185                 190                 195

 cat cca cag atg aac ttg cta gcc ttg gag aat aca gag ata ccc ccg      741
 His Pro Gln Met Asn Leu Leu Ala Leu Glu Asn Thr Glu Ile Pro Pro
                 200                 205                 210

 ttt gcc caa agg acc agc caa aac ctc acc tca agc cac gca tat gat      789
 Phe Ala Gln Arg Thr Ser Gln Asn Leu Thr Ser Ser His Ala Tyr Asp
             215                 220                 225

 aat ttt ctg gaa cat tca aat tca gtg ttt cta cag cca gtt agt cta      837
 Asn Phe Leu Glu His Ser Asn Ser Val Phe Leu Gln Pro Val Ser Leu
         230                 235                 240

 caa acc att gca gca gca cca tca aac cag agt ctg cca cct ttg ccc      885
 Gln Thr Ile Ala Ala Ala Pro Ser Asn Gln Ser Leu Pro Pro Leu Pro
     245                 250                 255

 agc aat cat cca gcg atg aca aaa agt gat ctc cag cca cct aat tac      933
 Ser Asn His Pro Ala Met Thr Lys Ser Asp Leu Gln Pro Pro Asn Tyr
 260                 265                 270                 275

 tac gag gta atg gag ttt gat ccc tta gct cct gct gtc act aca gaa      981
 Tyr Glu Val Met Glu Phe Asp Pro Leu Ala Pro Ala Val Thr Thr Glu
                 280                 285                 290

 gct att tat gaa gaa att gat gct cac cag cac aaa gga gct caa aat     1029
 Ala Ile Tyr Glu Glu Ile Asp Ala His Gln His Lys Gly Ala Gln Asn
             295                 300                 305

 gat ggt gac tga gaa gaaagtggat gatcagctca ctaccacatc aaaggtgcca     1084
 Asp Gly Asp 
         310

 actctctaaa acgtagactc tgtgcagctt tgaagcctgg aagacaatac ctaccaacat   1144

 gtcaaagcca tggtggcaca tttctgctat aatgaagatt aaatagaata acagttccag   1204

 gataacactg attcctgaca acagcgtgag atttcaacag aacttgtttg gaacaaatac   1264

 tcacttaaaa cttcagcaga agaaaaatta cttagtcctt aggccaacca atttaactgc   1324

 agtgtcatgt ttcacaggcc ttcctacatt tagaaatcgt cacacagctg tgataagagt   1384

 agattatttt actatgaaat aattctgaat agatgaaagc ataaaatgtg agaaactgaa   1444

 tgtattattc aggaagaata ctgagtgcct tcatttaact aaagttgaat gtaaaagtca   1504

 atttgcactt ctttataatc ctctggttta gaattataaa ttgttaaaac cttgataatt   1564

 gtcatttaat tatatttcag gtgtcctgaa caggtcacta gactctacat tgggcagcct   1624

 ttaaatatga ttctttgtaa tgctaaatag cctttttttc tctttttact gcaacttaat   1684

 atttctattt agaacacaga aaatgaaaat atttagaata agttgtacat ttgatgacaa   1744

 ataaatcact att                                                      1757




      <210> 228
      <211> 1385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (312)..(1325)

      <400> 228
 tgcttggtca tgagctgctg ggaagttgtg actttcactt tccctttcga attccagggt     60

 atatctggga ggccggagga cgtgtctggt tattacacag atgcacagct ggacgtggga    120

 tccacacagc tcagaacagt tggatcttgc tcagtctctg tcagaggaag atcccttgga    180

 caagaggacc ctgccttggt gtgagagtga gggaagagga agctggaacg agggttaagg    240

 aaaaccttcc agtctggaca gtgactggag agctccaagg aaagcccctc ggtaacccag    300

 ccgctggcac c atg aac cca gag agc agt atc ttt att gag gat tac ctt     350
              Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu
                1               5                  10

 aag tat ttc cag gac caa gtg agc aga gag aat ctg cta caa ctg ctg      398
 Lys Tyr Phe Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu
      15                  20                  25

 act gat gat gaa gcc tgg aat gga ttc gtg gct gct gct gaa ctg ccc      446
 Thr Asp Asp Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro
  30                  35                  40                  45

 agg gat gag gca gat gag ctc cgt aaa gct ctg aac aag ctt gca agt      494
 Arg Asp Glu Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser
                  50                  55                  60

 cac atg gtc atg aag gac aaa aac cgc cac gat aaa gac cag cag cac      542
 His Met Val Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His
              65                  70                  75

 agg cag tgg ttt ttg aaa gag ttt cct cgg ttg aaa agg gag ctt gag      590
 Arg Gln Trp Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu
          80                  85                  90

 gat cac ata agg aag ctc cgt gcc ctt gca gag gag gtt gag cag gtc      638
 Asp His Ile Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val
      95                 100                 105

 cac aga ggc acc acc att gcc aat gtg gtg tcc aac tct gtt ggc act      686
 His Arg Gly Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr
 110                 115                 120                 125

 acc tct ggc atc ctg acc ctc ctc ggc ctg ggt ctg gca ccc ttc aca      734
 Thr Ser Gly Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr
                 130                 135                 140

 gaa gga atc agt ttt gtg ctc ttg gac act ggc atg ggt ctg gga gca      782
 Glu Gly Ile Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala
             145                 150                 155

 gca gct gct gtg gct ggg att acc tgc agt gtg gta gaa cta gta aac      830
 Ala Ala Ala Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn
         160                 165                 170

 aaa ttg cgg gca cga gcc caa gcc cgc aac ttg gac caa agc ggc acc      878
 Lys Leu Arg Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr
     175                 180                 185

 aat gta gca aag gtg atg aag gag ttt gtg ggt ggg aac aca ccc aat      926
 Asn Val Ala Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn
 190                 195                 200                 205

 gtt ctt acc tta gtt gac aat tgg tac caa gtc aca caa ggg att ggg      974
 Val Leu Thr Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly
                 210                 215                 220

 agg aac atc cgt gcc atc aga cga gcc aga gcc aac cct cag tta gga     1022
 Arg Asn Ile Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly
             225                 230                 235

 gcg tat gcc cca ccc ccg cat gtc att ggg cga atc tca gct gaa ggc     1070
 Ala Tyr Ala Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly
         240                 245                 250

 ggt gaa cag gtt gag agg gtt gtt gaa ggc ccc gcc cag gca atg agc     1118
 Gly Glu Gln Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser
     255                 260                 265

 aga gga acc atg atc gtg ggt gca gcc act gga ggc atc ttg ctt ctg     1166
 Arg Gly Thr Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu
 270                 275                 280                 285

 ctg gat gtg gtc agc ctt gca tat gag tca aag cac ttg ctt gag ggg     1214
 Leu Asp Val Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly
                 290                 295                 300

 gca aag tca gag tca gct gag gag ctg aag aag cgg gct cag gag ctg     1262
 Ala Lys Ser Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu
             305                 310                 315

 gag ggg aag ctc aac ttt ctc acc aag atc cat gag atg ctg cag cca     1310
 Glu Gly Lys Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro
         320                 325                 330

 ggc caa gac caa tga ccccagagca gtgcagccac cagggcagaa atgccgggca     1365
 Gly Gln Asp Gln 
     335

 caggccagga caaaatgcag                                               1385




      <210> 229
      <211> 2433
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(1496)

      <400> 229
 aaaaagcggc ggtcgttgta ggtggctgcg gcagctgatg tggcctc  atg gat gag      56
                                                      Met Asp Glu
                                                        1

 ctg gta cac gac tta gcc tca gcc ttg gag cag aca tct gag cag aat      104
 Leu Val His Asp Leu Ala Ser Ala Leu Glu Gln Thr Ser Glu Gln Asn
       5                  10                  15

 aag ctt ggt gaa ctg tgg gag gag atg gcg ctg agc ccc cga cag cag      152
 Lys Leu Gly Glu Leu Trp Glu Glu Met Ala Leu Ser Pro Arg Gln Gln
  20                  25                  30                  35

 agg cgg cag ctt cgg aaa cgc cga ggt cgg aag cgt cgt tct gac ttc      200
 Arg Arg Gln Leu Arg Lys Arg Arg Gly Arg Lys Arg Arg Ser Asp Phe
                  40                  45                  50

 act cac ctg gca gag cat acc tgc tgc tac agc gag gcc tct gag tca      248
 Thr His Leu Ala Glu His Thr Cys Cys Tyr Ser Glu Ala Ser Glu Ser
              55                  60                  65

 agt ctg gat gag gcc act aag gac tgt cga gaa gtg gct ccg gtg acc      296
 Ser Leu Asp Glu Ala Thr Lys Asp Cys Arg Glu Val Ala Pro Val Thr
          70                  75                  80

 aat ttt agt gac tct gat gac aca atg gta gcc aaa cga cac cca gct      344
 Asn Phe Ser Asp Ser Asp Asp Thr Met Val Ala Lys Arg His Pro Ala
      85                  90                  95

 ctc aat gcc att gtc aag agt aag caa cat tct tgg cat gaa tct gac      392
 Leu Asn Ala Ile Val Lys Ser Lys Gln His Ser Trp His Glu Ser Asp
 100                 105                 110                 115

 tcc ttt act gaa aat gca cct tgt cga cca ctc agg cgc agg cgg aag      440
 Ser Phe Thr Glu Asn Ala Pro Cys Arg Pro Leu Arg Arg Arg Arg Lys
                 120                 125                 130

 gtg aag cga gtg aca tca gag gtg gct gct agc ctt cag cag aag ctg      488
 Val Lys Arg Val Thr Ser Glu Val Ala Ala Ser Leu Gln Gln Lys Leu
             135                 140                 145

 aag gtg tca gat tgg agc tat gag aga ggc tgc agg ttc aag tct gct      536
 Lys Val Ser Asp Trp Ser Tyr Glu Arg Gly Cys Arg Phe Lys Ser Ala
         150                 155                 160

 aag aag cag cgt ctg tcc cgc tgg aag gag aat act ccc tgg acc tca      584
 Lys Lys Gln Arg Leu Ser Arg Trp Lys Glu Asn Thr Pro Trp Thr Ser
     165                 170                 175

 tca ggc cac gga ttg tgt gaa tta gca gaa aat agg act ttc cta agc      632
 Ser Gly His Gly Leu Cys Glu Leu Ala Glu Asn Arg Thr Phe Leu Ser
 180                 185                 190                 195

 aaa aca gga agg aaa gaa agg atg gag tgt gaa aca gat gaa caa aaa      680
 Lys Thr Gly Arg Lys Glu Arg Met Glu Cys Glu Thr Asp Glu Gln Lys
                 200                 205                 210

 cag ggc tct gat gag aac atg tca gaa tgt gaa acc agc agt gtg tgt      728
 Gln Gly Ser Asp Glu Asn Met Ser Glu Cys Glu Thr Ser Ser Val Cys
             215                 220                 225

 agc agc agt gac act ggg ctc ttt acc aat gat gaa ggg cga caa ggt      776
 Ser Ser Ser Asp Thr Gly Leu Phe Thr Asn Asp Glu Gly Arg Gln Gly
         230                 235                 240

 gat gac gaa cag agt gat tgg ttc tat gaa gga gaa tgt gtc cca gga      824
 Asp Asp Glu Gln Ser Asp Trp Phe Tyr Glu Gly Glu Cys Val Pro Gly
     245                 250                 255

 ttc act gtc cct aat ctt ctg ccc aag tgg gct cct gat cat tgt tct      872
 Phe Thr Val Pro Asn Leu Leu Pro Lys Trp Ala Pro Asp His Cys Ser
 260                 265                 270                 275

 gaa gta gaa aga atg gat tct gga ttg gat aaa ttt tca gat tcc aca      920
 Glu Val Glu Arg Met Asp Ser Gly Leu Asp Lys Phe Ser Asp Ser Thr
                 280                 285                 290

 ttc ctt tta cct tct cgg cca gct caa aga ggg tac cat act cgc ttg      968
 Phe Leu Leu Pro Ser Arg Pro Ala Gln Arg Gly Tyr His Thr Arg Leu
             295                 300                 305

 aat cgt cta cct gga gct gca gct cga tgc ctc aga aag ggg cga aga     1016
 Asn Arg Leu Pro Gly Ala Ala Ala Arg Cys Leu Arg Lys Gly Arg Arg
         310                 315                 320

 agg ctg gtt ggg aag gag acc agc ata aac act ttg ggg act gag agg     1064
 Arg Leu Val Gly Lys Glu Thr Ser Ile Asn Thr Leu Gly Thr Glu Arg
     325                 330                 335

 ata agc cat atc att agt gac cct cgg cag aaa gaa aag aat aaa gcg     1112
 Ile Ser His Ile Ile Ser Asp Pro Arg Gln Lys Glu Lys Asn Lys Ala
 340                 345                 350                 355

 ttg gct tct gat ttt cct cac att tct gct tgt gca cat gag ttc aat     1160
 Leu Ala Ser Asp Phe Pro His Ile Ser Ala Cys Ala His Glu Phe Asn
                 360                 365                 370

 ccc ctg tct ccc ctt tac tcc ctg gat gtt ctt gcc gat gct tct cac     1208
 Pro Leu Ser Pro Leu Tyr Ser Leu Asp Val Leu Ala Asp Ala Ser His
             375                 380                 385

 cga agg tgt tca cca gca cac tgc tct gcc aga cag gca aat gta cac     1256
 Arg Arg Cys Ser Pro Ala His Cys Ser Ala Arg Gln Ala Asn Val His
         390                 395                 400

 tgg gga cca cca tgt tca cgt gac atc aag agg aag cgg aaa cca gtg     1304
 Trp Gly Pro Pro Cys Ser Arg Asp Ile Lys Arg Lys Arg Lys Pro Val
     405                 410                 415

 gcc aca gca tct ttg tct agc ccc agt gca gtt cac atg gat gca gtg     1352
 Ala Thr Ala Ser Leu Ser Ser Pro Ser Ala Val His Met Asp Ala Val
 420                 425                 430                 435

 gag cca acc aca cca gca tca caa gcc ccc aaa tca ccc agc tct gag     1400
 Glu Pro Thr Thr Pro Ala Ser Gln Ala Pro Lys Ser Pro Ser Ser Glu
                 440                 445                 450

 tgg ttg gtg agg acc tct gca gca gag aaa gcc aca gac gca act act     1448
 Trp Leu Val Arg Thr Ser Ala Ala Glu Lys Ala Thr Asp Ala Thr Thr
             455                 460                 465

 gct aca ttt ttt aaa atg cca caa gaa aag agc cct gga tac agc tag     1496
 Ala Thr Phe Phe Lys Met Pro Gln Glu Lys Ser Pro Gly Tyr Ser 
         470                 475                 480

 agagcaggac ttcaccctcc aggagctgac tgggtgttgc tgaagcaaat gttggacttt   1556

 gtgttagata gtcttgcata tcttaatcga cattcccagt cctttcacca ccagaaccaa   1616

 ctcctctttc aaacacagca gtggattctt tctctcagaa ggtcatgttg tgggaatctt   1676

 ttttttaaat agtgaaatat tgaggcagca attttttaca aaaaggtcat cctctgctct   1736

 atttgttacc ttgttattgc tgtctcaaca tttactacag ctccatttac agaactgttg   1796

 cttttttgca gttgtctttg ttcttgaaaa accagtaact gcttctgcat accttttgtg   1856

 tagagctttt aatatcattt gaggaagttc caaatttgta gccagttcca aacaaattta   1916

 aatattgagt tgagacctgt atggaattgt gttcgcagga gataaggctt gcctttgagc   1976

 ctactcttga ttcatgcaga gtgccaataa gataaatcaa ccaagttttg gggcctcaaa   2036

 agagacacca gcaactgggc cttgagaact tccatttttt tgcagattgt ctgcagaaac   2096

 tcagacagct catcagcagc agcagctgta ttgtatttta cctcatcttc agagtttatg   2156

 ttctactgaa agaggacgtg tgtatacaca cacacacaca cacacacaca cagattggta   2216

 taatggagaa gatggtttag gtgtacagca aatttaaaat agtcagtgga ttgtgtctta   2276

 ctacttcatg tcccagtgta agcctttatg tcctaagcag gactttattg ttagtattat   2336

 aggctaataa cctgcagcag aaattcatac tctattataa taatggcttc ttggggccat   2396

 gctttgggga agtaaaatgt ctttttgaca tgccttt                            2433




      <210> 230
      <211> 1268
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1221)

      <400> 230
 cacagggact gcgctccctt gcccctagcg ctcccgcgct gctgctccag ccgcccggca     60

 gctctgagg    atg gag agg agg gcg cgg agc tcc tcc agg gag tcc cgc     108
              Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg
                1               5                  10

 ggg cga ggc ggc agg act ccg cac aag gag aac aag agg gca aag gcc      156
 Gly Arg Gly Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala
      15                  20                  25

 gag agg agc ggc ggg ggc cgc ggg cgc cag gag gct ggg ccc gag ccg      204
 Glu Arg Ser Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro
  30                  35                  40                  45

 tcg ggc tcc gga cgg gcg ggg acc ccg ggg gag ccc cga gcg ccc gcc      252
 Ser Gly Ser Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala
                  50                  55                  60

 gcc acg gtg gtg gac gtg gat gag gtc cga ggc tcc ggc gag gag ggc      300
 Ala Thr Val Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly
              65                  70                  75

 acc gag gtg gtg gcg ctg ttg gag agc gag cgg ccc gag gaa ggt acc      348
 Thr Glu Val Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr
          80                  85                  90

 aaa tcc tcc ggc tta ggg gcc tgt gag tgg ctt ctt gtc ctc att tcc      396
 Lys Ser Ser Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser
      95                 100                 105

 ctg ctc ttc atc atc atg acc ttc cct ttt tcc atc tgg ttc tgc gta      444
 Leu Leu Phe Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val
 110                 115                 120                 125

 aag gtt gta caa gag tat gaa aga gta att ata ttc cga ctg gga cat      492
 Lys Val Val Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His
                 130                 135                 140

 ctg ctt cct gga aga gcc aaa ggc cct ggt ctt ttc ttt ttt ttg ccc      540
 Leu Leu Pro Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro
             145                 150                 155

 tgc ctg gat acc tac cac aag gtt gac ctt cgt ctc caa act ctg gag      588
 Cys Leu Asp Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu
         160                 165                 170

 ata cct ttt cat gag atc gtg acc aaa gac atg ttt ata atg gag ata      636
 Ile Pro Phe His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile
     175                 180                 185

 gat gcc att tgc tac tac cga atg gaa aat gcc tct ctt ctc cta agc      684
 Asp Ala Ile Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser
 190                 195                 200                 205

 agt ctt gct cat gta tct aaa gct gtg caa ttc ctt gtg caa acc act      732
 Ser Leu Ala His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr
                 210                 215                 220

 atg aag cgt ctc cta gca cat cga tcc ctc act gaa att ctt cta gag      780
 Met Lys Arg Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu
             225                 230                 235

 agg aag agc atc gcc caa gat gca aag gtt gcc ttg gat tca gtg acc      828
 Arg Lys Ser Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr
         240                 245                 250

 tgt att tgg gga atc aaa gtg gag aga ata gaa att aaa gat gtg agg      876
 Cys Ile Trp Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg
     255                 260                 265

 ttg cca gct ggg ctt cag cac tca ctg gct gtg gag gct gaa gcg caa      924
 Leu Pro Ala Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln
 270                 275                 280                 285

 aga caa gcc aaa gtg cgg atg att gct gca gaa gcg gaa aag gct gct      972
 Arg Gln Ala Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala
                 290                 295                 300

 tct gag tcc ctg agg atg gca gct gag att ctg tca ggc acc cct gct     1020
 Ser Glu Ser Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala
             305                 310                 315

 gct gtt cag ctt cga tac ctc cac acc ctt cag tct ctg tcc aca gag     1068
 Ala Val Gln Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu
         320                 325                 330

 aag cct tcc act gtg gtt tta cct ttg cca ttt gac cta ctg aat tgc     1116
 Lys Pro Ser Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys
     335                 340                 345

 ctg tct tct ccc agc aac aga act cag gga agc ctc ccc ttc cca agt     1164
 Leu Ser Ser Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser
 350                 355                 360                 365

 cct tcc aaa cct gtt gag cca cta aat cct aaa aag aaa gac tct ccc     1212
 Pro Ser Lys Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro
                 370                 375                 380

 atg tta tag gaaggat ggggcataat gtgactgtaa aggggcctgc catagaaaag     1268
 Met Leu 






      <210> 231
      <211> 2806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (725)..(1153)

      <400> 231
 tggagtaaac actgcctttg ttccctagcg cctcgtcttt cgtcgccccg tgccctcacg     60

 ccgccgggct ctggccggcc cgccctcggt ccttgaaccc catttcggct cgtgccgtgc    120

 ggatgcagct gccgggcctg ggtttgggca ttgagcggga ggaggaggag gagcggcggc    180

 gcctgggcgg catgcgatgg ggaactgctg ctggacgcag tgcttcggac tgcttcgcaa    240

 ggaagcgggg cggctgcagc gagtaggcgg cggcggagga tccaagtatt ttagaacatg    300

 ctcaagaggt gagcacttaa caatagagtt tgagaatcta gtagaaagtg atgaagggga    360

 gagcccagga agcagtcata gtttagcaaa catttattaa gcaactgtcg tgtgccaagc    420

 accgtgctag acactgggat tttaaaaatc agacatagtc tctccattag aagaaagaac    480

 atcctggtct gggagataga ttctcgagat gactaatttc aatatgaggc ctcttactga    540

 ggaagaaatt gttgacctaa gagaaaggca ttatgattcc attgccgaaa aacaaaaaga    600

 tcttgataag aaaattcaaa aagagcaaga aaggcagaga attgtgcagc aatatcatcc    660

 ttccaacaat ggagaatatc aaagttcagg accagaagat gacttcgaat cttgtttgag    720

 aaat atg aag tca cag tat gaa gtt ttt cga agt agt aga ctc tca tca     769
      Met Lys Ser Gln Tyr Glu Val Phe Arg Ser Ser Arg Leu Ser Ser
        1               5                  10                  15

 gat gct aca gtt ttg aca cca aat aca gaa agc agt tgt gat tta atg      817
 Asp Ala Thr Val Leu Thr Pro Asn Thr Glu Ser Ser Cys Asp Leu Met
                  20                  25                  30

 acc aaa act aaa tca act agt gga aat gac gac agc aca tcc tta gat      865
 Thr Lys Thr Lys Ser Thr Ser Gly Asn Asp Asp Ser Thr Ser Leu Asp
              35                  40                  45

 cta gag tgg gaa gat gaa gaa gga atg aat aga atg ctt cca atg aga      913
 Leu Glu Trp Glu Asp Glu Glu Gly Met Asn Arg Met Leu Pro Met Arg
          50                  55                  60

 gaa cgt tcc aaa aca gag gaa gac att cta cgg gca gca ctt aag tat      961
 Glu Arg Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala Ala Leu Lys Tyr
      65                  70                  75

 agc aac aag aag act gga agt aat cct aca tca gcc tct gat gat tcc     1009
 Ser Asn Lys Lys Thr Gly Ser Asn Pro Thr Ser Ala Ser Asp Asp Ser
  80                  85                  90                  95

 aat ggg ctg gag tgg gaa aat gat ttt gtt agt gcc gaa atg gat gat     1057
 Asn Gly Leu Glu Trp Glu Asn Asp Phe Val Ser Ala Glu Met Asp Asp
                 100                 105                 110

 aat gga aat tcc gag tat tct gga ttt gta aat cct gta tta gaa ctg     1105
 Asn Gly Asn Ser Glu Tyr Ser Gly Phe Val Asn Pro Val Leu Glu Leu
             115                 120                 125

 tct gat tct ggc ata agg cat tct gac aca gat caa cag act cga tag     1153
 Ser Asp Ser Gly Ile Arg His Ser Asp Thr Asp Gln Gln Thr Arg 
         130                 135                 140

 ggtaaaattg tgtgaccttg tttatcagtt atgaccaaat gttaaaaacc aactagaatg   1213

 tataagtgat tgtgcttagc ctttttgtaa gggagatgtg taagaaacca tgttgtaaat   1273

 gcttatttta ttacaaagga gtagggatga taggatctga attgatacag aattaagtgc   1333

 aatttcatca tctgccttct gcttttcaag accaatttaa tggtcctgtc atgttactga   1393

 ttaaatttac tttgtcttgt ctttatagca tttctgttta ctatggtaga tttccacttt   1453

 caatttttaa aattaatttt actttgaatg atttatgaag cctatttcat tgtctaacta   1513

 tgaaaatatt aagacttttt tgttaattct cagccgatgt gaaggaagca tgaggaggga   1573

 tcgtcagatt cagatttaga atagtgttcc cgtttccagc attatttatt tctatgactt   1633

 ctttggattt tattatctaa tagtaagtac agttgatgtg ggtagatgac tctaagaaat   1693

 gctgaagtat cggcattaca tgtgtttatt tacatgtcct agtatgataa tgttgattca   1753

 atctgaacaa aagataatat aaaaataacc cttcagagtt tggacatttc aagttggtaa   1813

 taataaaaaa taatatttaa gaagatatat atatatatat atatttagtt ttttccgctt   1873

 cattttacat gccactatat tgactttaat tgatatacag tattaagttt ttaggtgcca   1933

 ttatttttaa aaaattctat atttccaatg aacgatgtta gattttacac agaacatatt   1993

 ctctgcatga tttcagaaaa gaaaatctaa aaaggtaata cgggtatttc aaataaaatc   2053

 ctttctggta tgaaaggctc cattgatttt attaagcctt cctttacctt gtagtacaag   2113

 gtgctttaat gggatagaac taagcatatc aatatctata actgcatttt gtgctagaca   2173

 attactgttc ttttctctaa aatgtatatg tcaatttaca aggccaggga tagaaaacac   2233

 tccataattg ctttccttga ttttgctgag gatttggtat gattttagta agcaaactgt   2293

 tttttggttt ttccttaatg tttttaattt tttttcctct tgcaacaatg acggtgcatg   2353

 ttcttataaa tataggaagg tccagatata aatagtaacc taaagttctt gctgtgctta   2413

 aaaaaaaaaa tcatgtggcc ctttcaatat ttgaactgct aagcaatgac atctgtagtt   2473

 ttatctcctt ttttatgtca tagaaattaa tatgatactt taaatatgta aatataatac   2533

 attaggtaat gctattattt atatctgtct taacataatt taagttgtag ctgtgtcttg   2593

 gaaatatttt taaggtaatc tatattcaca ttgcctgtgt taatgctttt taaagtttgt   2653

 atacatcaga tgtatatttt tggtttggca taagctacga ttgtaatttt tcttggcttt   2713

 ttgttcataa agaatttttt gaaggaatgg taacaaatgg taatttacaa atggttgtga   2773

 ataaacacat ttttacactt aaaaaaaaaa aaa                                2806




      <210> 232
      <211> 1307
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (791)..(988)

      <400> 232
 aaacaaaaaa ctaaataaat ttattccata aagattttaa acttctacaa ttcattaaaa     60

 agacataaat tcaaaagtca aaatggtaaa aatattcaca acatatgaca atcaaatggt    120

 taatttcctt ttataaagag tttataggaa taaatgagaa agaagtaaac ccaaataaaa    180

 gtagacaaag gtcatgagca gttcatttaa aaagaaatac aaatatctat aaacatacga    240

 aaagataatc accttaatat cattaataat taatattttc tcccacatca gcaaaaatct    300

 gcatgtttgt taaagctgag tgttttaagg gtgtgatgaa atggacacca ttacacagga    360

 ctgcctttca ggaaggttct ctgccactgg aaaagggtac agcttttcta gagggcaata    420

 ggtgatttct attaaaatat caaagacaca ctccttgccc ttgtacttca actatttatc    480

 tgggcttagt acaagttctc ctagctacat gtacaaggat gctactgcaa catcatgcct    540

 tagagaaaaa ggcatagtat atttggtatt gtaccaatgt caatttccca gaattgatat    600

 tatactacag ttgtcaccac tgggggaaga gtactcaggg actctatgta ctacttttgc    660

 aacttcctat gagactataa ttacttcaaa ataaaaagtg tttctttaaa aaaatcatgg    720

 tgcataagta tttatggttt cttacaaagt atgaaaaggt aagggcaatc cttgtttaat    780

 taaattcaaa   atg agt gag cag aac ata tgt aac cag aag gac aaa tcc     829
              Met Ser Glu Gln Asn Ile Cys Asn Gln Lys Asp Lys Ser
                1               5                  10

 acc ctt ccc ttt tgt caa gca cat ctg tgt gaa gag acc acc aac agg      877
 Thr Leu Pro Phe Cys Gln Ala His Leu Cys Glu Glu Thr Thr Asn Arg
      15                  20                  25

 ctt tgt gtg agc aac aag gct gtt tat tca ctt gag tgc aag tgg gct      925
 Leu Cys Val Ser Asn Lys Ala Val Tyr Ser Leu Glu Cys Lys Trp Ala
  30                  35                  40                  45

 gag tct gaa aac aga gtc agt gaa ggg aga tgg gga agg ggt tgc ttt      973
 Glu Ser Glu Asn Arg Val Ser Glu Gly Arg Trp Gly Arg Gly Cys Phe
                  50                  55                  60

 ata gga gtt ggg tag gtaatggaaa attacagtaa aaagtggtta tctattgtta     1028
 Ile Gly Val Gly 
              65

 gcagaggagg gggtcacaag gtacatggtg gggagatgat aagacccatt gtccagaaga   1088

 agactgtcac aaggtcgatt gatcagttaa ggtaggacag ggacaggtca caatggtgga   1148

 atgttgtaat gttggttaat cagttaaggc aggaactggc tgttttactt cttgtgtggt   1208

 ttttcagctg ccccagactt cttggctcct gcaggccatc tggacatata tgtgcaggtc   1268

 acaggggtta caatggctga gcttcggctc agaggcctg                          1307




      <210> 233
      <211> 736
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (470)..(703)

      <400> 233
 aattcactag gaacactata gggaattagg ccctcgaggc aagaaattcg gcacgaggca     60

 cccatgtatt gggcttagtc aggattgaca gatacattct cagctggcct gtcatataaa    120

 acatactgtc attgagctta agctccgctt gttctgaggt ttcacctcca tgtgtttcat    180

 tggtgcaaaa gtggatctct tagttggtca cttaattctt tctttttcag aaagatagta    240

 tgttcactgg tatatttggt cactcttaga accttccttc acattgtttt ttatgggacc    300

 catgaatggt tagcctttct tttctattgt agaaggaaat aaataggagt aaaaagacca    360

 ttgtagtaaa taagttcaag gggaacttgg gaccagaaac cactgttatg tacaaaaaaa    420

 tggcaaattc aataaactca aatttaaaat aatttttaaa ttaacagtt    atg ata     475
                                                          Met Ile
                                                            1

 aat ttt ata ttt tat aca aat aga ttg ctt aga atg gtt ctc aag aat      523
 Asn Phe Ile Phe Tyr Thr Asn Arg Leu Leu Arg Met Val Leu Lys Asn
           5                  10                  15

 tat aag aga aat gaa ctc aca gta caa aaa ttt tat aat tac tat act      571
 Tyr Lys Arg Asn Glu Leu Thr Val Gln Lys Phe Tyr Asn Tyr Tyr Thr
      20                  25                  30

 tgt gtt ttg ttt ggg ggc tgg gaa atg tat ttt tac att gta gcc aat      619
 Cys Val Leu Phe Gly Gly Trp Glu Met Tyr Phe Tyr Ile Val Ala Asn
  35                  40                  45                  50

 cat ttt ata ttt gtc aat tta aat ctt atg ggt ctt ttt ttt ttt atc      667
 His Phe Ile Phe Val Asn Leu Asn Leu Met Gly Leu Phe Phe Phe Ile
                  55                  60                  65

 tct ctt gat gtc aga ttt tat agt ctt ttt aaa taa atcc atttaattaa      717
 Ser Leu Asp Val Arg Phe Tyr Ser Leu Phe Lys 
              70                  75

 aacgttaaaa aaaaaaaaa                                                 736




      <210> 234
      <211> 1973
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (268)..(783)

      <400> 234
 ccggaattcc cgggtcgacg atttcgtcgc tcaagcatgg cggcggcggc attgggcagc     60

 tcctcaggct cggcgtcccc ggccgtggct gagctctgcc agaacacccc ggagaccttt    120

 ttggaggcct ccaagctgct gctcacctat gctgacaaca tcctcagaaa ccctaatgat    180

 gaaaaatata gatccatccg gattggaaac acagcctttt ctactagact cttgcctgtc    240

 agaggagctg ttgaatgttt atttgaa    atg ggc ttt gaa gag gga gaa aca     291
                                  Met Gly Phe Glu Glu Gly Glu Thr
                                    1               5

 cat ctc atc ttt cct aaa aaa gct tca gtg gag cag ctg caa aaa att      339
 His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu Gln Leu Gln Lys Ile
      10                  15                  20

 cgt gac ctg att gcc ata gag aga agt agc aga ctg gat ggc tca aat      387
 Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg Leu Asp Gly Ser Asn
  25                  30                  35                  40

 aag agc cac aaa gta aag tca tct cag caa cct gca gcc agt acc cag      435
 Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro Ala Ala Ser Thr Gln
                  45                  50                  55

 ctt cct aca aca cca tct tca aat ccc agt ggg tta aac cag cac aca      483
 Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly Leu Asn Gln His Thr
              60                  65                  70

 agg aac cgt caa ggg cag tca tca gat cca cca tct gct tca acg gtt      531
 Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro Ser Ala Ser Thr Val
          75                  80                  85

 gct gct gac tca gcc att cta gaa gtt ctt cag tcc aac att cag cat      579
 Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln Ser Asn Ile Gln His
      90                  95                 100

 gtg ctg gtc tat gaa aat cct gct ctt cag gag aaa gcg ttg gct tgt      627
 Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu Lys Ala Leu Ala Cys
 105                 110                 115                 120

 att ccg gtc caa gaa cta aaa agg aaa tca caa gaa aag tta tcg aga      675
 Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln Glu Lys Leu Ser Arg
                 125                 130                 135

 gct aga aaa ttg gat aaa gat ata ata acc ctg aga aac ttt tgg aaa      723
 Ala Arg Lys Leu Asp Lys Asp Ile Ile Thr Leu Arg Asn Phe Trp Lys
             140                 145                 150

 caa gat gtg gac ggt gtg gcg agt ggg cca att gtt tta cac tgt gct      771
 Gln Asp Val Asp Gly Val Ala Ser Gly Pro Ile Val Leu His Cys Ala
         155                 160                 165

 gcc gag ctg tag ggt ttgaagctcg ctatgtttgg gattacgcag accatgtctg      826
 Ala Glu Leu 
     170

 gacagaagtc tattctcctt ctcagcagcg gtggctgcac tgtgatgcat gtgaagatgt    886

 ctgtgacaag ccactccttt atgaaatagg atggggcaag aagctttcct atgtcatagc    946

 attttcaaaa gatgaggtag ttgatgtcac ttggcgatat tcctgcaaac atgaagaggt   1006

 gattgccaga agaactaagg ttaaagaagc attacttcga gacactatta atgggcttaa   1066

 taagcagagg caactgtttt tgtcagaaaa cagaaggaaa gaacttctcc agaggataat   1126

 tgtggagctt gttgaattta tatctcccaa aacccctaaa cctggagaac ttgggggaag   1186

 aatatctggg tcagtggctt ggagagtagc ccgaggtgaa atgggtctac agagaaaaga   1246

 aaccttgttt attccctgtg aaaatgagaa gatttctaaa cagctccacc tttgttacaa   1306

 tattgtgaaa gatcgttatg ttcgagtttc aaataacaat caaaccattt ctggatggga   1366

 gaatggcgtg tggaaaatgg aatctatatt cagaaaagtt gaaacagact ggcacatggt   1426

 atatttggcc cgaaaggaag gatcatcttt tgcttatatt tcctggaagt ttgagtgtgg   1486

 gtcagttggc ctaaaagtag atagcatttc tattagaaca agtagtcaaa cttttcagac   1546

 tggaacagta gaatggaaat tgcgatctga tacagcacaa gtagaactga caggcgataa   1606

 cagtcttcac tcctatgctg atttttctgg tgccactgaa gttattttgg aagcagaatt   1666

 aagcagagga gatggtgatg tcgcttggca acacacccag ctgtttagac aaagcttaaa   1726

 tgaccatgaa gaaaattgtt tggagataat tataaaattc agtgaccttt gagaacctga   1786

 acattataga aaagctggca ataatcaagg acttactgaa gtagtctgtt ggttcagtgc   1846

 atgcttagtt ggcagttacc accctgtgct agcatatttc ttttgctagc tatccatcat   1906

 gtaaccctca tgaaaattat ctttatacgt ggactataat aaaatattga attaaaacct   1966

 ttcttcc                                                             1973




      <210> 235
      <211> 1602
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (358)..(1248)

      <400> 235
 aagggaaggg cggagctggg gtgagggtcc aaggggccca ggacttggcc ggcgtgatct     60

 cagctctgca gaccctgcgg tgctgggagc caccatggag agtaggtgct acggctgcgc    120

 tgtcaagttc accctcttca agaaggaggc tgcctaagct tcagtgcagc agtgcctcgg    180

 actgggaaca cccaacagaa agtctgcaag caatgccatg aggtcctgac cagagggtct    240

 tctgccaatg cctccaagtg gtcaccacct cagaactata agaagcgtgt ggcagccttg    300

 gaagccaagc aaaagcccag cacttcccag agccagggac tgacacgaca agaccag       357                                                                 
 atg att gct gag cgc cta gca cga ctc cgc cag gag aac aag ccc aag      405
 Met Ile Ala Glu Arg Leu Ala Arg Leu Arg Gln Glu Asn Lys Pro Lys
   1               5                  10                  15

 tta gtc ccc tca cag gca gag ata gag gca cgg ctg gct gcc cta aag      453
 Leu Val Pro Ser Gln Ala Glu Ile Glu Ala Arg Leu Ala Ala Leu Lys
              20                  25                  30

 gat gaa cgt cag ggt tcc atc cct tcc acc cag gaa atg gag gca cga      501
 Asp Glu Arg Gln Gly Ser Ile Pro Ser Thr Gln Glu Met Glu Ala Arg
          35                  40                  45

 ctt gca gcg ttg cag ggc aga gtt cta cct tct caa acc ccc cag ccg      549
 Leu Ala Ala Leu Gln Gly Arg Val Leu Pro Ser Gln Thr Pro Gln Pro
      50                  55                  60

 gca cat cac aca ccg gac acc agg acc caa gcc cag cag aca cag gat      597
 Ala His His Thr Pro Asp Thr Arg Thr Gln Ala Gln Gln Thr Gln Asp
  65                  70                  75                  80

 ctg cta acg cag ctg gca gct gag gtg gct atc gat gaa agc tgg aaa      645
 Leu Leu Thr Gln Leu Ala Ala Glu Val Ala Ile Asp Glu Ser Trp Lys
                  85                  90                  95

 gga gga ggc cca gct gcc tct ctc cag aat gat ctc aac cag ggt ggc      693
 Gly Gly Gly Pro Ala Ala Ser Leu Gln Asn Asp Leu Asn Gln Gly Gly
             100                 105                 110

 cca ggg agc act aat tcc aag agg cag gcc aac tgg tcc ttg gag gag      741
 Pro Gly Ser Thr Asn Ser Lys Arg Gln Ala Asn Trp Ser Leu Glu Glu
         115                 120                 125

 gag aag agc aga ctg ctg gct gag gca gca ctt gag ttg cgg gag gag      789
 Glu Lys Ser Arg Leu Leu Ala Glu Ala Ala Leu Glu Leu Arg Glu Glu
     130                 135                 140

 aac acg agg cag gaa cgg att ctg gcc ctg gcc aag cga cta gcc atg      837
 Asn Thr Arg Gln Glu Arg Ile Leu Ala Leu Ala Lys Arg Leu Ala Met
 145                 150                 155                 160

 ctg cgg gga cag gac ccc gag aga gtg acc ctc cag gac tat cgc ctc      885
 Leu Arg Gly Gln Asp Pro Glu Arg Val Thr Leu Gln Asp Tyr Arg Leu
                 165                 170                 175

 cca gac agt gat gac gac cag gat gag gag aca gcc atc caa aga gtc      933
 Pro Asp Ser Asp Asp Asp Gln Asp Glu Glu Thr Ala Ile Gln Arg Val
             180                 185                 190

 ctg cag cag ctc act gaa gaa gct gcc ctg gat gag gca agt ggc ttt      981
 Leu Gln Gln Leu Thr Glu Glu Ala Ala Leu Asp Glu Ala Ser Gly Phe
         195                 200                 205

 aac atc cct gca gag cag gct tct cga ccc tgg acg caa ccc cgc ggg     1029
 Asn Ile Pro Ala Glu Gln Ala Ser Arg Pro Trp Thr Gln Pro Arg Gly
     210                 215                 220

 cca gag cct gag gcc cag gat gtg gac ccc agg cct gag gct gag gaa     1077
 Pro Glu Pro Glu Ala Gln Asp Val Asp Pro Arg Pro Glu Ala Glu Glu
 225                 230                 235                 240

 gag gag ctc ccc tgg tgc tgc atc tgc aat gag gat gcc acc cta cgc     1125
 Glu Glu Leu Pro Trp Cys Cys Ile Cys Asn Glu Asp Ala Thr Leu Arg
                 245                 250                 255

 tgc gct gga tgc gat ggg gac ctc ttc tgt gcc cgc tgc ttc cga gag     1173
 Cys Ala Gly Cys Asp Gly Asp Leu Phe Cys Ala Arg Cys Phe Arg Glu
             260                 265                 270

 ggc cat gat gcc ttt gag ctt aaa gag cac cag aca tct gcc tac tct     1221
 Gly His Asp Ala Phe Glu Leu Lys Glu His Gln Thr Ser Ala Tyr Ser
         275                 280                 285

 cct cca cgt gca ggc caa gag cac tga agata ccctggtcct cccggaaggg     1273
 Pro Pro Arg Ala Gly Gln Glu His 
     290                 295

 cagtcccaca ggcagcggca cccatttctg ggccccgcca caggacgtcc gatgggagag   1333

 cttgtctggc tctactgatg atggataggc cccttcctga gccttggtgt ccctggaatg   1393

 aggaaagatt ctccattcga gagaatgact gggagggaag aagtcggggc cctcctatta   1453

 gaagcccaga ctggaagtga gaggcatgat ggggagagac cagactgaat ctacgggtga   1513

 gccctgtaac ctggctctag ggcacaggcc cctcccctgg cacttagtgg gtctaataaa   1573

 gtatgttgat tcattggaaa aaaaaaaaa                                     1602




      <210> 236
      <211> 1999
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(453)

      <400> 236
 cctctgcctt cgcccctgtc ccgggagggt gggaagcttt gaccccgccc tgcccactcg     60

 cgtctccgca gccgtagccg cgcctgtccc aat atg aat agg gtc aac gac cca     114
                                      Met Asn Arg Val Asn Asp Pro
                                        1               5

 ctt att ttt ata aga gat att aag ccc gga ctg aaa aac tta aat gtc      162
 Leu Ile Phe Ile Arg Asp Ile Lys Pro Gly Leu Lys Asn Leu Asn Val
          10                  15                  20

 gtc ttt att gtc ctg gag ata gga cgc gtg acc aaa acc aaa gac ggc      210
 Val Phe Ile Val Leu Glu Ile Gly Arg Val Thr Lys Thr Lys Asp Gly
      25                  30                  35

 cat gaa gtg aga tcg tgc aaa gta gca gat aaa acg ggc agc atc act      258
 His Glu Val Arg Ser Cys Lys Val Ala Asp Lys Thr Gly Ser Ile Thr
  40                  45                  50                  55

 att tcc gtg tgg gat gag atc gga ggt ctt ata cag cca ggg gat att      306
 Ile Ser Val Trp Asp Glu Ile Gly Gly Leu Ile Gln Pro Gly Asp Ile
                  60                  65                  70

 att cgg ttg acc aga ggg tat gca tcc atg tgg aaa gga tgt ctg aca      354
 Ile Arg Leu Thr Arg Gly Tyr Ala Ser Met Trp Lys Gly Cys Leu Thr
              75                  80                  85

 ctt tat act gga agg ggt ggt gaa ctt caa aaa att ggg gat cta ggt      402
 Leu Tyr Thr Gly Arg Gly Gly Glu Leu Gln Lys Ile Gly Asp Leu Gly
          90                  95                 100

 gcg gtg cag gca gcc gca atg cga gat tcc ata cac tac tac cct ggg      450
 Ala Val Gln Ala Ala Ala Met Arg Asp Ser Ile His Tyr Tyr Pro Gly
     105                 110                 115

 taa tgat ctccaccctg acctggagga gccatcctct ctaggggtgt aagattttgt      507
 


 atggtttatt cagaagtgcc aaatttcagt gaacccaacc cagattatcg aggacagcag    567

 aacaaagggg cacagagtga acagaagaat aattccatga atagtaatat gggtacaggt    627

 acatttggac cagtgggaaa tggtgttcac actggccctg aatcaaggga acaccagttt    687

 tcacatgctg gcagaagcaa tggccgggga cttataaatc cacaactaca aggaacagct    747

 agtaatcaaa cagtgatgac cacaataagt aatggcaggg accctcggag agcctttaaa    807

 agatgaccta tgctaaatac tcatgtgtag tttttatact acatgcccta cttgaacact    867

 tattgcactt ttatttattg ttaactgtga aaagtacgtc ctttattggg tttcctttta    927

 tattcttggt ttgttaagaa gaatggtttg tttttatagc aaaactgtta agctgctcga    987

 gtctcctgtt gaagaatggg aacactgaaa agtaggggca tttattttta gagtaaaaag   1047

 attattggat agcctttaaa aaacctgcac ccatttcatg ggtgagttac ttaagacatc   1107

 agctttatag cctctatgag tctatcttct gtataagttt tgtaatattt aacataaggc   1167

 ttaatgggag atgttctttt gtcttgtatt cagatattgc caactaaagc aataaccatc   1227

 aaaaaacaca agaacttgtc aatgctagca gtaatttttg agtgtttgtg gctctcggaa   1287

 tgattgactt cgttcagtga ctactattaa gattttccaa ggactgactc atcccaaatt   1347

 tttgttgtat taccaaaaaa acagattcct tatcagaatt tggaatagaa tgtgatctct   1407

 attgcaacaa gtaattttaa aagaaagcta catttatttt agagtagtgc tcctaacatg   1467

 tattatcaac tttgtggatt acattggagg aaaatttaaa actggggcct tgaatattta   1527

 ttttttgaaa ctaccatgtt aaatactgaa gtataatttg ggggagttat aaagttatga   1587

 taaacattca tctgattatt ttaaacaata gttgtggtag ataaacatac tggaggtgag   1647

 tcaaattgaa ttcatatagt aacatgcagt ctgaagtcct agttacttaa taggtactca   1707

 gcctggagtg aaaatcctgg gtactgactt tgagaggagt gagtgtgcat gttgtcaaag   1767

 tttctgaaca cagttcacat agccttatta gcaaaagttt taagaaatgg ctctatcaaa   1827

 gaagcaattg cagctttatt cagaaatata aaagtggaat ttatgtacat gtcataagtg   1887

 gtacccactt ccccttttta ctgtagggtg gataactctt aggatttaac tctttgaata   1947

 ttatctcttg aataaagcat gtgttaatgt taacaaacct aaaaaaaaaa aa           1999




      <210> 237
      <211> 2633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(1172)

      <400> 237
 ccgtacgcct gaggcaccgg accggaattc ccgggtcgac gatttcgtcg cagcccaaga     60

 aaagaaagct tgagtctggg ggcggcggcg aaggagggga gggaactgaa gagcaagatg    120

 gcgcggagcg ggaggcggcc ctggagcgac cccggaggac taagcgggaa cgggaccagc    180

 tgtactacga gtgctactcg gacgtttcgg tccacgagga g    atg atc gcg gac     233
                                                  Met Ile Ala Asp
                                                    1

 cgc gtc cgc acc gat gcc tac cgc ctg ggt atc ctt cgg aac tgg gca      281
 Arg Val Arg Thr Asp Ala Tyr Arg Leu Gly Ile Leu Arg Asn Trp Ala
   5                  10                  15                  20

 gca ctg cga ggc aag acg gta ctg gac gtg ggc gcg ggc acc ggc att      329
 Ala Leu Arg Gly Lys Thr Val Leu Asp Val Gly Ala Gly Thr Gly Ile
                  25                  30                  35

 ctg agc atc ttc tgt gcc cag gcc ggg gcc cgg cgc gtg tac gcg gta      377
 Leu Ser Ile Phe Cys Ala Gln Ala Gly Ala Arg Arg Val Tyr Ala Val
              40                  45                  50

 gag gcc agc gcc atc tgg caa cag gcc cgg gag gtg gtg cgg ttc aac      425
 Glu Ala Ser Ala Ile Trp Gln Gln Ala Arg Glu Val Val Arg Phe Asn
          55                  60                  65

 ggg ctg gag gac cgg gtg cac gtc ctg ccg gga cca gtg gag act gta      473
 Gly Leu Glu Asp Arg Val His Val Leu Pro Gly Pro Val Glu Thr Val
      70                  75                  80

 gag ttg ccg gaa cag gtg gat gcc atc gtg agc gag tgg atg ggc tac      521
 Glu Leu Pro Glu Gln Val Asp Ala Ile Val Ser Glu Trp Met Gly Tyr
  85                  90                  95                 100

 gga ctc ctg cac gag tcc atg ctg agc tcc gtc ctc cac gcg cga acc      569
 Gly Leu Leu His Glu Ser Met Leu Ser Ser Val Leu His Ala Arg Thr
                 105                 110                 115

 aag tgg ctg aag gag ggc ggt ctt ctc ctg ccg gcc tcc gcc gag ctc      617
 Lys Trp Leu Lys Glu Gly Gly Leu Leu Leu Pro Ala Ser Ala Glu Leu
             120                 125                 130

 ttc ata gcc ccc atc agc gac cag atg ctg gaa tgg cgc ctg ggc ttc      665
 Phe Ile Ala Pro Ile Ser Asp Gln Met Leu Glu Trp Arg Leu Gly Phe
         135                 140                 145

 tgg agc cag gtg aag cag cac tat ggt gtg gac atg agc tgc ctg gag      713
 Trp Ser Gln Val Lys Gln His Tyr Gly Val Asp Met Ser Cys Leu Glu
     150                 155                 160

 ggc ttc gcc acg cgc tgt ctc atg ggc cac tcg gag atc gtt gtg cag      761
 Gly Phe Ala Thr Arg Cys Leu Met Gly His Ser Glu Ile Val Val Gln
 165                 170                 175                 180

 gga ttg tcc ggc gag gac gtg ctg gcc cgg ccg cag cgc ttt gct cag      809
 Gly Leu Ser Gly Glu Asp Val Leu Ala Arg Pro Gln Arg Phe Ala Gln
                 185                 190                 195

 cta gag ctc tcc cgc gcc ggc ttg gag cag gag ctg gag gcc gga gtg      857
 Leu Glu Leu Ser Arg Ala Gly Leu Glu Gln Glu Leu Glu Ala Gly Val
             200                 205                 210

 ggc ggg cgc ttc cgc tgc agc tgc tat ggc tcg gcg ccc atg cat ggc      905
 Gly Gly Arg Phe Arg Cys Ser Cys Tyr Gly Ser Ala Pro Met His Gly
         215                 220                 225

 ttt gcc atc tgg ttc cag gtg acc ttc cct gga ggg gag tcg gag aaa      953
 Phe Ala Ile Trp Phe Gln Val Thr Phe Pro Gly Gly Glu Ser Glu Lys
     230                 235                 240

 ccc ctg gtg ctg tcc acc tcg cct ttt cac ccg gcc act cac tgg aaa     1001
 Pro Leu Val Leu Ser Thr Ser Pro Phe His Pro Ala Thr His Trp Lys
 245                 250                 255                 260

 cag gcg ctc ctc tac ctg aac gag ccg gtg caa gtg gag caa gac acg     1049
 Gln Ala Leu Leu Tyr Leu Asn Glu Pro Val Gln Val Glu Gln Asp Thr
                 265                 270                 275

 gac gtt tca gga gag atc acg ctg ctg ccc tcc cgg gac aac ccc cgt     1097
 Asp Val Ser Gly Glu Ile Thr Leu Leu Pro Ser Arg Asp Asn Pro Arg
             280                 285                 290

 cgc ctg cgc gtg ctg ctg cgc tac aaa gtg gga gac cag gag gag aag     1145
 Arg Leu Arg Val Leu Leu Arg Tyr Lys Val Gly Asp Gln Glu Glu Lys
         295                 300                 305

 acc aaa gac ttt gcc atg gag gac tga gcgtt gccttttctc ccagctacct     1197
 Thr Lys Asp Phe Ala Met Glu Asp 
     310                 315

 cccaaagcag cctgacctgc gtgggagagg cgtagcgagg tcggagggga aagggagatc   1257

 ccacgtgcaa gtagggggaa tatctccccc ttttccctca tagcctctag ggagggagag   1317

 tgacttcatt ctccatttga agagattctt ctggtgatgt ttacttaaaa agtgatcccc   1377

 ctcaacaacg gatacagcgt gcttattatt gggcatttag cctcaaaagc atgtagtacc   1437

 aagcacttgt atttccgtat attttgtttc gcgggggagt gagggggaag aacacggatg   1497

 aaaatgtcag tttttgaagg gtccatgcac atccctgaca cctcacacct tatctaagtc   1557

 tgaagctggg gagaaagggg ttcatttaga cttcatacat ttccagtacg actttagtat   1617

 ctctccagag ccatattttc tcagtccgaa ttaattcccc ctccctaggt gcctgtaggc   1677

 tatggtactt cttcctcatt gttttctagg taaacttcac tactggtaat taaggggaag   1737

 gatatgagga agcagtttaa atagccctgt tctcattact ctgaccacat acatcatagg   1797

 gtgctaaagt tgatgaacac attaatccgt taagtaaaat ggactttgta attgtacagc   1857

 atacctaaga aactcagaag gtgcatttaa gagagagacc tgaaagaaat agtatggatt   1917

 tttaaaaatt cttgtctcta ctattataac caaaaaatat ttcttgtatg tcccataaaa   1977

 atatttgtgt aattcttatg aaacaggctg gtagaggagg tttctgagcc tagcccaagg   2037

 gcttattcat caccatgggt aaattattta aactcactta attaaggaaa atattttccc   2097

 agctagaaaa gtatactcat tctcatttaa actctctcat ttggagggat catgtgagtt   2157

 ggcctactta caagtagtga aagttccctt ttcagttttg ttttgttttg ttttgttttt   2217

 ctctttcact cagccaaatg tgaaagttgt gaatttagga aaatcacttg taatgaagtg   2277

 tgaatcttgt tatcaaattt atttctctga tgtttccttc cttatccttg tagccaataa   2337

 aacattgaca ttctcacgtt ttatagatga ggtaaaaagt cttgtgtgct gtgagttata   2397

 atgcttttgc ctttttaata ttattagttc ttaagtgtta cagccccttc agaatataac   2457

 ttcaggacaa ttcaaactat gcttaatgta tgattttcga gcttctgtat gctaagaaaa   2517

 taggtgtgaa aaactggtgt tctgaaatag cctaacattt attgtaattc tgaattttct   2577

 gcccttttat tcattgcata ttaaagtatt agagtataaa aactaaaaaa aaaaaa       2633




      <210> 238
      <211> 1126
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(876)

      <400> 238
 tcgccccggc aacagccgcc tccctcgcgt cccccactcc ccctctgtct ctccaaggaa     60

 aactaggccc ctgcgcggcc aacgcccagg atccgcaagc tgcgcgccca cgagtttcag    120

 cacccatttg gactttcaca atcagag    atg gca gcg gta aag gca tca aca     171
                                  Met Ala Ala Val Lys Ala Ser Thr
                                    1               5

 tcg aaa gct acc agg cct tgg tat tct cat ccg gta tat gca aga tac      219
 Ser Lys Ala Thr Arg Pro Trp Tyr Ser His Pro Val Tyr Ala Arg Tyr
      10                  15                  20

 tgg caa cat tat cat caa gca atg gct tgg atg caa agc cat cac aat      267
 Trp Gln His Tyr His Gln Ala Met Ala Trp Met Gln Ser His His Asn
  25                  30                  35                  40

 gcc tac agg aag gcc gtg gaa tcc tgt ttc aat ctt cca tgg tac tta      315
 Ala Tyr Arg Lys Ala Val Glu Ser Cys Phe Asn Leu Pro Trp Tyr Leu
                  45                  50                  55

 cct tct gcg ctt ctt ccc caa agc tct tac gat aat gag gct gcg tat      363
 Pro Ser Ala Leu Leu Pro Gln Ser Ser Tyr Asp Asn Glu Ala Ala Tyr
              60                  65                  70

 cct cag tcc ttc tat gac cat cat gtg gcc tgg cag gac tac ccc tgc      411
 Pro Gln Ser Phe Tyr Asp His His Val Ala Trp Gln Asp Tyr Pro Cys
          75                  80                  85

 agt tct tca cat ttc aga aga tct ggg cag cat cca cgt tac agc agt      459
 Ser Ser Ser His Phe Arg Arg Ser Gly Gln His Pro Arg Tyr Ser Ser
      90                  95                 100

 agg atc cag gca tcc aca aaa gaa gac caa gct ttg tcc aaa gag gaa      507
 Arg Ile Gln Ala Ser Thr Lys Glu Asp Gln Ala Leu Ser Lys Glu Glu
 105                 110                 115                 120

 gag atg gag act gag tca gat gca gag gta gaa tgt gac ctg agc aat      555
 Glu Met Glu Thr Glu Ser Asp Ala Glu Val Glu Cys Asp Leu Ser Asn
                 125                 130                 135

 atg gaa atc act gaa gag ctc cgc cag tac ttt gca gag acc gag agg      603
 Met Glu Ile Thr Glu Glu Leu Arg Gln Tyr Phe Ala Glu Thr Glu Arg
             140                 145                 150

 cat aga gaa gaa cga cgg cgg cag cag cag ctg gat gca gag cgc ctg      651
 His Arg Glu Glu Arg Arg Arg Gln Gln Gln Leu Asp Ala Glu Arg Leu
         155                 160                 165

 gac agc tat gtg aac gct gac cac gac ctg tac tgc aac acc cgc cgg      699
 Asp Ser Tyr Val Asn Ala Asp His Asp Leu Tyr Cys Asn Thr Arg Arg
     170                 175                 180

 tcg gta gaa gcc cca act gag agg cct ggt gag cgg cgc cag gcc gag      747
 Ser Val Glu Ala Pro Thr Glu Arg Pro Gly Glu Arg Arg Gln Ala Glu
 185                 190                 195                 200

 atg aag cgt ttg tac ggg gac agt gct gcc aag atc caa gcc atg gag      795
 Met Lys Arg Leu Tyr Gly Asp Ser Ala Ala Lys Ile Gln Ala Met Glu
                 205                 210                 215

 gcc gcg gtg cag ctg agc ttt gac aag cac tgt gac cga aag cag ccc      843
 Ala Ala Val Gln Leu Ser Phe Asp Lys His Cys Asp Arg Lys Gln Pro
             220                 225                 230

 aag tac tgg ccg gtc atc ccc ctg aag ttc tga gctcaggg cacagggtac      894
 Lys Tyr Trp Pro Val Ile Pro Leu Lys Phe 
         235                 240

 ccagcctctc cttcttcctt ttgggtacac gctctttatc tctccttctg tacatttctt    954

 agggaaaggg gactttgtac tggggtacag gcatgttcac cacagtccca gtgggcctgt   1014

 cacggggtgg atgtactatg ccagccactt ggaggtctgc aggacatgtt ctgttgccaa   1074

 catgataaat tttctcctga cataaaataa ttttgcatat aaaaaaaaaa aa           1126




      <210> 239
      <211> 1398
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(956)

      <400> 239
 cgccgccttc aggagacaga attggccaag gcctgaaggc cccggagtgc accagcggc      59                                                                 
 atg tac aaa gag acc gtc tac tcc gcc ttc aat ctg ctc atg cat tac      107
 Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr
   1               5                  10                  15

 cca ccc ccc tcg gga gca ggg cag cac ccc cag ccg cag ccc ccg ctg      155
 Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu
              20                  25                  30

 cac aag gcc aat cag ccc ccc cac ggt gtc ccc caa ctc tct ctc tac      203
 His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr
          35                  40                  45

 gaa cat ttc aac agc cca cat ccc acc cct gca cct gcg gac atc agc      251
 Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser
      50                  55                  60

 cag aag caa gtt cac agg cct ctg cag acc cct gac ctc tct ggc ttc      299
 Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe
  65                  70                  75                  80

 tac tcc ctg acc tca ggc agc atg ggg cag ctc ccc cac act gtg agc      347
 Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser
                  85                  90                  95

 tgg ttc acc cac cca tcc ttg atg cta ggt tct ggt gta cct ggt cac      395
 Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His
             100                 105                 110

 cca gca gcc atc ccc cac ccg gcc att gtg ccc ccc tca ggg aag cag      443
 Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln
         115                 120                 125

 gag ctg cag ccc ttc gac cgc aac ctg aag aca caa gca gag tcc aag      491
 Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys
     130                 135                 140

 gca gag aag gag gcc aag aag cca acc atc aag aag ccc ctc aat gcc      539
 Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala
 145                 150                 155                 160

 ttc atg ctg tac atg aag gag atg aga gcc aag gtc att gca gag tgc      587
 Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys
                 165                 170                 175

 aca ctt aag gag agc gct gcc atc aac cag atc ctg ggc cgc agg tgg      635
 Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp
             180                 185                 190

 cac gcg ctg tcg cga gaa gag cag gcc aag tac tat gag ctg gcc cgc      683
 His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg
         195                 200                 205

 aag gag agg cag ctg cac atg cag cta tac cca ggc tgg tca gcg cgg      731
 Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg
     210                 215                 220

 gac aac tac ggg aag aag aag agg cgg tcg agg gaa aag cac caa gaa      779
 Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu
 225                 230                 235                 240

 tcc acc aca gag aca aac tgg ccc aga gaa ctc aag gaa gga ctg gga      827
 Ser Thr Thr Glu Thr Asn Trp Pro Arg Glu Leu Lys Glu Gly Leu Gly
                 245                 250                 255

 tgg ctg ggc aag gaa gcc ata ggc att gcg gcc cct tgc ctt ggt gca      875
 Trp Leu Gly Lys Glu Ala Ile Gly Ile Ala Ala Pro Cys Leu Gly Ala
             260                 265                 270

 gat gtg agt ccc aca aac aca tct gga gaa gct caa agg ccg gga ctg      923
 Asp Val Ser Pro Thr Asn Thr Ser Gly Glu Ala Gln Arg Pro Gly Leu
         275                 280                 285

 gga gat gac tcc ctt gga aga cag gag aga tga ctcccttg gaagacagat      974
 Gly Asp Asp Ser Leu Gly Arg Gln Glu Arg 
     290                 295

 gacagcccat aggcctagtg acaaaaggcc cctttgccac cttgtggctg ttctgggaac   1034

 tgcacctgtc ctaggtctgg gccagaccaa gcagaatggc agtctgagga cactgactta   1094

 ccacccaagt cccaggaaga gaggacaagg aatcagccag gcctgtgcaa aggcagcatt   1154

 ttttggttgt ggtgtatgac tatgaattca ccctctgttt acagataact ctcttcacta   1214

 ttcctaggag gaaaaagaaa tgcattcggt acttacccgg agaaggccgc tgccccagcc   1274

 ccgttccttc cgatgacagt gctctaggct gccccgggtc cccagctccc caggactcac   1334

 cctcatacca tccgctgccc cagccccgtt ccttccgatg acagtgctct aggctgcccc   1394

 ggcg                                                                1398




      <210> 240
      <211> 2659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(942)

      <400> 240
 gcgctccagg ccggtcgctc caccccccgg ctcccgggac tgtggactcc acgaccctgt     60

 cctcggccct gtccgcgccg aagcagcccg ggactgcgca gcgccccgcg tgccgac       117                                                                 
 atg gga aag tct ctt tct cat ttg cct ttg cat tca agc aaa gaa gat      165
 Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp
   1               5                  10                  15

 gct tat gat gga gtc aca tct gaa aac atg agg aat gga ctg gtt aat      213
 Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn
              20                  25                  30

 agt gaa gtc cat aat gaa gat gga aga aat gga gat gtc tct cag ttt      261
 Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe
          35                  40                  45

 cca tat gtg gaa ttt aca gga aga gat agt gtc acc tgc cct act tgt      309
 Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys
      50                  55                  60

 cag gga aca gga aga att cct agg ggg caa gaa aac caa ctg gtg gca      357
 Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala
  65                  70                  75                  80

 ttg att cca tat agt gat cag aga tta agg cca aga aga aca aag ctg      405
 Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu
                  85                  90                  95

 tat gtg atg gct tct gtg ttt gtc tgt cta ctc ctt tct gga ttg gct      453
 Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala
             100                 105                 110

 gtg ttt ttc ctt ttc cct cgc tct atc gac gtg aaa tac att ggt gta      501
 Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val
         115                 120                 125

 aaa tca gcc tat gtc agt tat gat gtt cag aag cgt aca att tat tta      549
 Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu
     130                 135                 140

 aat atc aca aac aca cta aat ata aca aac aat aac tat tac tct gtc      597
 Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val
 145                 150                 155                 160

 gaa gtt gaa aac atc act gcc caa gtt caa ttt tca aaa aca gtt att      645
 Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile
                 165                 170                 175

 gga aag gca cgc tta aac aac ata agc att att ggt cca ctt gat atg      693
 Gly Lys Ala Arg Leu Asn Asn Ile Ser Ile Ile Gly Pro Leu Asp Met
             180                 185                 190

 aaa caa att gat tac aca gta cct acc gtt ata gca gag gaa atg agt      741
 Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser
         195                 200                 205

 tat atg tat gat ttc tgt act ctg ata tcc atc aaa gtg cat aac ata      789
 Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile
     210                 215                 220

 gta ctc atg atg caa gtt act gtg aca aca aca tac ttt ggc cac tct      837
 Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser
 225                 230                 235                 240

 gaa cag ata tcc cag gag agg tat cag tat gtc gac tgt gga aga aac      885
 Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn
                 245                 250                 255

 aca act tat cag ttg ggg cag tct gaa tat tta aat gta ctt cag cca      933
 Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro
             260                 265                 270

 caa cag taa aaactgg aagagatgga tttaaagaag aaatatctat tgatatttcc      989
 Gln Gln 


 tatactctca atgaagaggt atttcctaat aggagacctt aaattgaaca aacctaaagt   1049

 ttacacttct aagagtacag ttaaaagtat gtggacctgc agttcttgta actctccact   1109

 ctgtgttaat gatatatttg tactaggatc ttttacttga atctaaattt actggttgat   1169

 ttccttctcc agcctatccc ctacagggaa aagctgatac ttcccctata gtacaataaa   1229

 taattattta aaagtcatag ctccagtcac tactgaaaac ataattttgg tgataaacat   1289

 aatttgagaa acttaatttc tgaatgtttt tatagaaaat tactgaaaat ctattactca   1349

 tggaagactt ttaaagagta accttttttc ctgttttata aattcccatt gttatatggt   1409

 agtatttcag ctacacaata ttttagcttt tagctagaca tttataggtt ttcatttgtt   1469

 gaaatggtaa tcatctgcat gtttttgtca cttatttcag gttagtgatt gcctaacact   1529

 tataagccaa aataatcttt gcaaaattcc atacctaaaa ttttgaaagc ccctaatgtt   1589

 ttcacacatc tttctgtatt agttatagtt ttgtgaaatc tttgtgtgat cttcaaacat   1649

 tatcatttaa tgtacaatac tgtaaataaa ctgtgcatgg cttttataca gctttagtaa   1709

 atgtcaaata aagtggtaca gactcattac aacaagtttc tcataaaaat acaataaata   1769

 ggaaaatgaa attcagaaac ccatagactg ggaataggtt ccagttacag cttggatctg   1829

 gcataaaata aatttgaaat aaaatatttt gatgctccat ttttttatgt tgcttttcat   1889

 actaaagaat ggtgtagact tgttttgcaa ctgttaggta cccagttatc aattttatca   1949

 atgttttaga ggaggaaatt atttttttgg tagaaattgt tcaagaaatc cttaattgaa   2009

 tgtcattaaa tgatggtggc caaaataaaa cctatttaga aatttaatca ctttgcacat   2069

 cacttggaat atgatgcctc tagtagttac ttttttatag ttttctactt ttggttttat   2129

 ttaaaattgt tttcaaatat agattattga cttattcaac tttgctgttt tatattttca   2189

 gtatcatttt tcatttgttt tttttttttt tgtcttttca cttaccaagt tctagggaca   2249

 tttaaaatat gtactaagtg taggagtggt tatgatacca aaaaatgtag ctgggttgag   2309

 attaatttcg ttctgttttc tcatgacaga aatcaggttt ccctttcccc acccctaagt   2369

 gcctaactta ggtctgaaac agcctgttta ttagtctgac tctctcaacc ataaaacata   2429

 agctttattt aattctgcct ttaaacacac tcaggtttcc ccttaatttt catattattt   2489

 tctgcaagtt ttcttgagta tcttcaattc gttgaatgtg gtttttggtt tttttttgtt   2549

 ttaacactag tcttccctta attcattgct aactcaagcc atccttacta ttaaacccaa   2609

 atcagtcctt taagttcatt atggcctttc tagtatttaa aaaaaaaaaa              2659




      <210> 241
      <211> 2034
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(608)

      <400> 241
 cgctgcggcg ccttgtgatt ggaggaggca acggtcactt ggcagcgccg ttgggattgg     60

 gggaagagga ccccggctgt aggtgacgct gaggcggcga gggtgagtcg gcgccggccg    120

 ctaccgcact tcgggcgctc gtccctcatt tctctgtggt gaatggcgac ggg   atg     176
                                                              Met
                                                                1

 gag cgc gag ggg agc ggc ggc agc ggc ggg tcg gcc ggg ctc ctg cag      224
 Glu Arg Glu Gly Ser Gly Gly Ser Gly Gly Ser Ala Gly Leu Leu Gln
               5                  10                  15

 cag atc ctg agc ctg aag gtt gtg ccg cgg gtg ggc aac ggg acc ctg      272
 Gln Ile Leu Ser Leu Lys Val Val Pro Arg Val Gly Asn Gly Thr Leu
          20                  25                  30

 tgc ccc aac tct act tcc ctc tgc tcc ttc cca gag atg tgg tat ggt      320
 Cys Pro Asn Ser Thr Ser Leu Cys Ser Phe Pro Glu Met Trp Tyr Gly
      35                  40                  45

 gta ttc ctg tgg gca ctg gtg tct tct ctc ttc ttt cat gtc cct gct      368
 Val Phe Leu Trp Ala Leu Val Ser Ser Leu Phe Phe His Val Pro Ala
  50                  55                  60                  65

 gga tta ctg gcc ctc ttc acc ctc aga cat cac aaa tat ggt agg ttc      416
 Gly Leu Leu Ala Leu Phe Thr Leu Arg His His Lys Tyr Gly Arg Phe
                  70                  75                  80

 atg tct gta agc atc ctg ttg atg ggc atc gtg gga cca att act gct      464
 Met Ser Val Ser Ile Leu Leu Met Gly Ile Val Gly Pro Ile Thr Ala
              85                  90                  95

 gga atc ttg aca agt gca gct att gct gga gtt tac cga gca gca ggg      512
 Gly Ile Leu Thr Ser Ala Ala Ile Ala Gly Val Tyr Arg Ala Ala Gly
         100                 105                 110

 aag gaa atg ata cca ttt gaa gcc ctc aca ctg ggc act gga cag aca      560
 Lys Glu Met Ile Pro Phe Glu Ala Leu Thr Leu Gly Thr Gly Gln Thr
     115                 120                 125

 ttt tgc gtc ttg gtg gtc tcc ttt tta cgg att tta gct act cta tag      608
 Phe Cys Val Leu Val Val Ser Phe Leu Arg Ile Leu Ala Thr Leu 
 130                 135                 140

 catacatcct tatgctgaga tgttgaactt aaactttatg gaatcctcca aaagaataca    668

 ttatggagtg tagtgttttc ttagttcttc aaagggaagc aacttggatg aacaggaaca    728

 tgaaggacaa cacatctcag ccttttcttc attttgaagc tcctagaatt gaagacttat    788

 gtggactcct attgttctca accaaaacaa gtcttttggc tttctttttt gtagatattt    848

 aatttaagca gttttcatgt gtacctttac ccaagccaag tcaacagtgt ctctggggtg    908

 gcatcctttg cactgaaatt tacagtattc tgtgagatgt cgcatatttt gaagaaaccg    968

 tggaagatac tggtttattt caaatgagca gagtatgttg tattaaaatc ttatctaatc   1028

 ttgattaaaa tttggcaaac tcttttcttt gctacatctt agtgacaata aatgccaaat   1088

 aggttttggt tgagtatagt tttgaaaaca aatttggtga aataaagcag gaaaaaaaat   1148

 ttaagtataa ctcaagtagt ggctttggtt ccactgttta taaataaaaa gtagataaca   1208

 atgaataatg tgacattttc tggacaactg tcttgacttc tgattaagat attttaagag   1268

 atgtgaattt gttattttgt atgttttatc aaaataagct agctaattta gactttttag   1328

 attttctgta ccacctttcc ctatcacttt taattctctt aattttattt catttaattg   1388

 gaaacataca taccctatta aatggcttga gttggaaatt ttaagccaga tttgtttgga   1448

 cattgaggca cacataagat actttaggca ttctgtcata gtttttctta gtgactttgg   1508

 tatactaatg acccttgaga aactatagaa gtgcatctga aactagagtt agtggttatt   1568

 gattttttag cttaatgtgt ttacctagtg gtaactcttc agcccacttt tacagtattg   1628

 ggtatcaact cccagaaagt gcctaaagtt taatgttcag atatgtaccc actctcccct   1688

 ttacattttt attcaaaaga atttatatct ttaaagagat ttaaatatca agagtttttt   1748

 taaaacttaa ttttagctat ttaaattttt attctactgc ctaactttct ttttcattaa   1808

 aaggcctgaa aactgtgact ctttgagagg gaaagaatcg cagaaattaa gtatttaatg   1868

 tgatcctttc cacctaaact gttttgtatg gaatacaatc agtgtggtgg tagtggcggt   1928

 ggatatctgc gccatagtct ctggtgacta aatccgactc ttttttttcc ctccgccccc   1988

 cagcagccgg gtcccccacc ccttttccct ggccctggct ccgaaa                  2034




      <210> 242
      <211> 687
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (372)..(626)

      <400> 242
 ctgcggaatt ccgcacgagg caggagccgc ggagccggcg ctgagagggg ctgcggccgg     60

 agcgggcggc tgagacaaag gcgacgacta tctgttatag tccctgggtc aagacaacaa    120

 tttttatacc ttcgtcgtgg ttcagaaagg agtctctgta gaaccagaag caaagaaagg    180

 aaacaatcca aatttttctt tattaaatcg actgtgtaag atacttgact tccaggaaca    240

 aaaacacggt gaaataataa aatttcatct tggcatcact ggacatcatc gtattgagga    300

 gcgtattttt ggaacttccc gagttgagat ttggaacctt cattggtgct catttactgt    360

 ggactgtaag c atg agt gaa ttc tgg ttg tgt ttc aac tgc tgt att gca     410
              Met Ser Glu Phe Trp Leu Cys Phe Asn Cys Cys Ile Ala
                1               5                  10

 gaa cag cct cag cct aaa agg cga cgg cgg att gac aga agt atg att      458
 Glu Gln Pro Gln Pro Lys Arg Arg Arg Arg Ile Asp Arg Ser Met Ile
      15                  20                  25

 gga gag ccc aca aac ttt gtg cat aca gct cat gtt gga tca gga gac      506
 Gly Glu Pro Thr Asn Phe Val His Thr Ala His Val Gly Ser Gly Asp
  30                  35                  40                  45

 ctg ttc agt gga atg aat tca gtt agc tcc att cag aac caa atg cag      554
 Leu Phe Ser Gly Met Asn Ser Val Ser Ser Ile Gln Asn Gln Met Gln
                  50                  55                  60

 tcc aag gga ggt tat gga ggt gga atg cct gcc aat gtc cag atg cag      602
 Ser Lys Gly Gly Tyr Gly Gly Gly Met Pro Ala Asn Val Gln Met Gln
              65                  70                  75

 ctc gtg gac acg aag gcg gga tag ccctggtcct ttctccaggt tattgtgaat     656
 Leu Val Asp Thr Lys Ala Gly 
          80

 ttctatattt tctctgtcca ctattctgta a                                   687




      <210> 243
      <211> 2404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (508)..(1947)

      <400> 243
 ggtagacatc tcgcgtggcc ctgcgagcag cagtgccgag atgaacccca gtgctcccta     60

 gctacgtcct cgctgtacgt gggggacctc catcccgacg tgaccgaggc gatgctctac    120

 aagaagttca gcgcggccgg gctcatcctc tccatccggg tctgcaggga catgatcacc    180

 cacggctcct tgggctacgc gtatgtgaac ttccagtagc ccgcggacgc ggagcatgct    240

 gtgaacacta tgaattttga tgttataaag ggcaagccag tacgcatcgt gtagtctcag    300

 cgtgatccat cacttcgcaa aagtggagtg ggctacatat tcattaaaaa tctggacaaa    360

 tccattgata ataaagcact gtatgataca gtttctgctt ttggtaacat cctttcgtgt    420

 aacgtggttt gtgatgaaaa tggttccaag ggttatggat ttgtacactt tgagacacac    480

 gaagcagctg aaagagctat taaaaaa    atg aac gga atg ctc cta aat ggt     531
                                  Met Asn Gly Met Leu Leu Asn Gly
                                    1               5

 cgc aaa gta ttt gtt gga caa ttt aag tct cgt aaa gaa cga gaa gct      579
 Arg Lys Val Phe Val Gly Gln Phe Lys Ser Arg Lys Glu Arg Glu Ala
      10                  15                  20

 gaa ctt gga gct agg gca aaa gag ttc ccc aat gtt tac atc aag aat      627
 Glu Leu Gly Ala Arg Ala Lys Glu Phe Pro Asn Val Tyr Ile Lys Asn
  25                  30                  35                  40

 ttt gga gaa gac atg gat gat gag cgc ctt aag gat ctc ttt ggc aag      675
 Phe Gly Glu Asp Met Asp Asp Glu Arg Leu Lys Asp Leu Phe Gly Lys
                  45                  50                  55

 ttc ggg ccc gcc tta agt gtg aaa gta atg act gat gaa agt gga aaa      723
 Phe Gly Pro Ala Leu Ser Val Lys Val Met Thr Asp Glu Ser Gly Lys
              60                  65                  70

 tcc aaa gga ttt gga ttt gta agc ttt gaa agg cat gaa gat gca cag      771
 Ser Lys Gly Phe Gly Phe Val Ser Phe Glu Arg His Glu Asp Ala Gln
          75                  80                  85

 aaa gct gtg gat gag atg aac gga aag gag ctc aat gga aaa caa att      819
 Lys Ala Val Asp Glu Met Asn Gly Lys Glu Leu Asn Gly Lys Gln Ile
      90                  95                 100

 tat gtt ggt cga gct cag aaa aag gtg gaa cgg cag acg gaa ctt aag      867
 Tyr Val Gly Arg Ala Gln Lys Lys Val Glu Arg Gln Thr Glu Leu Lys
 105                 110                 115                 120

 cgc aaa ttt gaa cag atg aaa caa gat agg atc acc aga tac cag ggt      915
 Arg Lys Phe Glu Gln Met Lys Gln Asp Arg Ile Thr Arg Tyr Gln Gly
                 125                 130                 135

 gtt aat ctt tat gtg aaa aat ctt gat gat ggt att gat gat gaa cgt      963
 Val Asn Leu Tyr Val Lys Asn Leu Asp Asp Gly Ile Asp Asp Glu Arg
             140                 145                 150

 ctc cgg aaa gag ttt tct cca ttt ggt aca atc act agt gca aag gtt     1011
 Leu Arg Lys Glu Phe Ser Pro Phe Gly Thr Ile Thr Ser Ala Lys Val
         155                 160                 165

 atg atg gag ggt ggt cgc agc aaa ggg ttt ggt ttt gta tgt ttc tcc     1059
 Met Met Glu Gly Gly Arg Ser Lys Gly Phe Gly Phe Val Cys Phe Ser
     170                 175                 180

 tcc cca gaa gaa gcc act aaa gca gtt aca gaa atg aac ggt aga att     1107
 Ser Pro Glu Glu Ala Thr Lys Ala Val Thr Glu Met Asn Gly Arg Ile
 185                 190                 195                 200

 gtg gcc aca aag cca ttg tat gta gct tta gct cag cgc aaa gaa gag     1155
 Val Ala Thr Lys Pro Leu Tyr Val Ala Leu Ala Gln Arg Lys Glu Glu
                 205                 210                 215

 cgc cag gct cac ctc act aac cag tat atg cag aga atg gca agt gta     1203
 Arg Gln Ala His Leu Thr Asn Gln Tyr Met Gln Arg Met Ala Ser Val
             220                 225                 230

 cga gct gtt ccc aac cct gta atc aac ccc tac cag cca gca cct cct     1251
 Arg Ala Val Pro Asn Pro Val Ile Asn Pro Tyr Gln Pro Ala Pro Pro
         235                 240                 245

 tca ggt tac ttc atg gca gct atc cca cag act cag aac cgt gct gca     1299
 Ser Gly Tyr Phe Met Ala Ala Ile Pro Gln Thr Gln Asn Arg Ala Ala
     250                 255                 260

 tac tat cct cct agc caa att gct caa cta aga cca agt cct cgc tgg     1347
 Tyr Tyr Pro Pro Ser Gln Ile Ala Gln Leu Arg Pro Ser Pro Arg Trp
 265                 270                 275                 280

 act gct cag ggt gcc aga cct cat cca ttc caa aat atg ccc ggt gct     1395
 Thr Ala Gln Gly Ala Arg Pro His Pro Phe Gln Asn Met Pro Gly Ala
                 285                 290                 295

 atc cgc cca gct gct cct aga cca cca ttt agt act atg aga cca gct     1443
 Ile Arg Pro Ala Ala Pro Arg Pro Pro Phe Ser Thr Met Arg Pro Ala
             300                 305                 310

 tct tca cag gtt cca cga gtc atg tca aca cag cgt gtt gct aac aca     1491
 Ser Ser Gln Val Pro Arg Val Met Ser Thr Gln Arg Val Ala Asn Thr
         315                 320                 325

 tca aca cag aca atg ggt cca cgt cct gca gct gca gcc gct gca gct     1539
 Ser Thr Gln Thr Met Gly Pro Arg Pro Ala Ala Ala Ala Ala Ala Ala
     330                 335                 340

 act cct gct gtc cgc acc gtt cca cag tat aaa tat gct gca gga gtt     1587
 Thr Pro Ala Val Arg Thr Val Pro Gln Tyr Lys Tyr Ala Ala Gly Val
 345                 350                 355                 360

 cgc aat cct cag caa cat ctt aat gca cag cca caa gtt aca atg caa     1635
 Arg Asn Pro Gln Gln His Leu Asn Ala Gln Pro Gln Val Thr Met Gln
                 365                 370                 375

 cag cct gct gtt cat gta caa ggt cag gaa cct ttg act gct tcc atg     1683
 Gln Pro Ala Val His Val Gln Gly Gln Glu Pro Leu Thr Ala Ser Met
             380                 385                 390

 ttg gca tct gcc cct cct caa gag caa aag caa atg ttg ggt gaa cgg     1731
 Leu Ala Ser Ala Pro Pro Gln Glu Gln Lys Gln Met Leu Gly Glu Arg
         395                 400                 405

 ctg ttt cct ctt att caa gcc atg cac cct act ctt gct ggt aaa atc     1779
 Leu Phe Pro Leu Ile Gln Ala Met His Pro Thr Leu Ala Gly Lys Ile
     410                 415                 420

 act ggc atg ttg ttg gag att gat aat tca gaa ctt ctt cat atg ctc     1827
 Thr Gly Met Leu Leu Glu Ile Asp Asn Ser Glu Leu Leu His Met Leu
 425                 430                 435                 440

 gag tct cca gag tca ctc cgt tct aag gtt gat gaa gct gta gct gta     1875
 Glu Ser Pro Glu Ser Leu Arg Ser Lys Val Asp Glu Ala Val Ala Val
                 445                 450                 455

 cta caa gcc cac caa gct aaa gag gct gcc cag aaa gca gtt aac agt     1923
 Leu Gln Ala His Gln Ala Lys Glu Ala Ala Gln Lys Ala Val Asn Ser
             460                 465                 470

 gcc acc ggt gtt cca act gtt taa aattgatcag ggaccatgaa aagaaacttg    1977
 Ala Thr Gly Val Pro Thr Val 
         475

 tgcttcaccg aagaaaaata tctaaacatc gaaaaactta aatattatgg aaaaaaaaca   2037

 ttgcaaaata taaaataaat aaaaaaagga aaggaaactt tgaaccttat gtaccgagca   2097

 aatgccaggt ctagcaaaca taatgctagt cctagattac ttattgattt aaaaacaaaa   2157

 aaacacaaaa aaatagtaaa atataaaaac aaattaatgt tttatagacc ctgggaaaaa   2217

 gaattttcag caaagtacaa aaatttaaag cattcctttc tttaattttg taattcttta   2277

 ctgtggaata gctcagaatg tcagttctgt tttaagtaac agaattgata actgagcaag   2337

 gaaacgtaat ttggattata aaattcttgc tttaataaaa attccttaaa cagtgaaaaa   2397

 aaaaaaa                                                             2404




      <210> 244
      <211> 4387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(1681)

      <400> 244
 agcccgttca gggccgcggg agtgcgccag cgccgcgcgt ggggctgtgg tggccgcggc     60

 tctcagatat atttttgcca tc atg gat cag ttt gga gat ata tta gaa ggt     112
                          Met Asp Gln Phe Gly Asp Ile Leu Glu Gly
                            1               5                  10

 gaa gtg gac cat tct ttc ttt gac agt gac ttt gaa gaa gga aag aaa      160
 Glu Val Asp His Ser Phe Phe Asp Ser Asp Phe Glu Glu Gly Lys Lys
                  15                  20                  25

 tgt gaa act aac tca gtt ttt gac aag caa aat gat gac cca aag gaa      208
 Cys Glu Thr Asn Ser Val Phe Asp Lys Gln Asn Asp Asp Pro Lys Glu
              30                  35                  40

 aga ata gat aaa gat aca aaa aat gta aat tcg aac act gga atg caa      256
 Arg Ile Asp Lys Asp Thr Lys Asn Val Asn Ser Asn Thr Gly Met Gln
          45                  50                  55

 aca aca gaa aat tat ctt act gag aag gga aat gaa aga aac gtg aaa      304
 Thr Thr Glu Asn Tyr Leu Thr Glu Lys Gly Asn Glu Arg Asn Val Lys
      60                  65                  70

 ttt ccc cca gaa cac ccc gta gag aat gat gtt aca caa act gta agt      352
 Phe Pro Pro Glu His Pro Val Glu Asn Asp Val Thr Gln Thr Val Ser
  75                  80                  85                  90

 tct ttc tca ttg cca gcc tct tca aga tca aaa aaa ttg tgt gat gtt      400
 Ser Phe Ser Leu Pro Ala Ser Ser Arg Ser Lys Lys Leu Cys Asp Val
                  95                 100                 105

 aca aca gga ctt aaa ata cac gtg tcc att cca aat aga att ccc aaa      448
 Thr Thr Gly Leu Lys Ile His Val Ser Ile Pro Asn Arg Ile Pro Lys
             110                 115                 120

 att gta aaa gaa ggt gaa gat gat tac tac aca gat gga gag gaa agc      496
 Ile Val Lys Glu Gly Glu Asp Asp Tyr Tyr Thr Asp Gly Glu Glu Ser
         125                 130                 135

 agt gat gat ggg aag aaa tac cat gtg aag tcc aag tcc gct aaa cca      544
 Ser Asp Asp Gly Lys Lys Tyr His Val Lys Ser Lys Ser Ala Lys Pro
     140                 145                 150

 tct act aac gtt aaa aaa agc ata agg aaa aag tat tgc aaa gtt agc      592
 Ser Thr Asn Val Lys Lys Ser Ile Arg Lys Lys Tyr Cys Lys Val Ser
 155                 160                 165                 170

 tcc tct tcc tcc tcc tct tta tct tcc tca tct tca ggt tca ggt aca      640
 Ser Ser Ser Ser Ser Ser Leu Ser Ser Ser Ser Ser Gly Ser Gly Thr
                 175                 180                 185

 gat tgt tta gat gca ggg tct gat agc cat cta tct gat tcg tct ccg      688
 Asp Cys Leu Asp Ala Gly Ser Asp Ser His Leu Ser Asp Ser Ser Pro
             190                 195                 200

 tca tct aag tca tct aag aaa cat gta tct ggt ata acc ctc ctg tca      736
 Ser Ser Lys Ser Ser Lys Lys His Val Ser Gly Ile Thr Leu Leu Ser
         205                 210                 215

 cca aaa cac aag tat aaa tca gga ata aaa tcg aca gaa aca cag cct      784
 Pro Lys His Lys Tyr Lys Ser Gly Ile Lys Ser Thr Glu Thr Gln Pro
     220                 225                 230

 tca agt act aca cca aaa tgt ggc cac tac cct gag gag tct gaa gat      832
 Ser Ser Thr Thr Pro Lys Cys Gly His Tyr Pro Glu Glu Ser Glu Asp
 235                 240                 245                 250

 act gtg act gac gta agt ccc tta tca act cca gac att agc cct ctt      880
 Thr Val Thr Asp Val Ser Pro Leu Ser Thr Pro Asp Ile Ser Pro Leu
                 255                 260                 265

 cag tct ttt gaa ctg ggc ata gca aat gat caa aaa gtg aaa att aaa      928
 Gln Ser Phe Glu Leu Gly Ile Ala Asn Asp Gln Lys Val Lys Ile Lys
             270                 275                 280

 aag caa gaa aat gtg agc caa gaa ata tat gaa gat gtt gag gat ttg      976
 Lys Gln Glu Asn Val Ser Gln Glu Ile Tyr Glu Asp Val Glu Asp Leu
         285                 290                 295

 aaa aat aat tca aaa tat ttg aaa gca gcc aaa aaa ggg aaa gaa aaa     1024
 Lys Asn Asn Ser Lys Tyr Leu Lys Ala Ala Lys Lys Gly Lys Glu Lys
     300                 305                 310

 cat gag cct gat gtc tcc tca aag tcg tct tca gtg tta gac tcc agt     1072
 His Glu Pro Asp Val Ser Ser Lys Ser Ser Ser Val Leu Asp Ser Ser
 315                 320                 325                 330

 tta gac cac aga cat aaa cag aaa gtc tta cat gac aca atg gat ctg     1120
 Leu Asp His Arg His Lys Gln Lys Val Leu His Asp Thr Met Asp Leu
                 335                 340                 345

 aat cat ctc ttg aaa gct ttt ctg caa tta gat aaa aaa gga cca caa     1168
 Asn His Leu Leu Lys Ala Phe Leu Gln Leu Asp Lys Lys Gly Pro Gln
             350                 355                 360

 aaa cat cac ttt gat cag cct tca gta gca ccc ggg aaa aac tac tct     1216
 Lys His His Phe Asp Gln Pro Ser Val Ala Pro Gly Lys Asn Tyr Ser
         365                 370                 375

 ttc aca aga gaa gag gtg aga cag atc gat cgg gaa aat cag agg ctt     1264
 Phe Thr Arg Glu Glu Val Arg Gln Ile Asp Arg Glu Asn Gln Arg Leu
     380                 385                 390

 ttg aaa gaa ctg tca aga cag gcg gaa aag cca gga agc aaa agt aca     1312
 Leu Lys Glu Leu Ser Arg Gln Ala Glu Lys Pro Gly Ser Lys Ser Thr
 395                 400                 405                 410

 att cct aga tcg gct gat cat ccc cca aag tta tat cac agt gct ctc     1360
 Ile Pro Arg Ser Ala Asp His Pro Pro Lys Leu Tyr His Ser Ala Leu
                 415                 420                 425

 aac aga cag aag gaa caa caa agg att gag aga gaa aac ttg gct tta     1408
 Asn Arg Gln Lys Glu Gln Gln Arg Ile Glu Arg Glu Asn Leu Ala Leu
             430                 435                 440

 ttg aaa agg ctt gag gcc gtg aaa cca aca gtt ggt atg aaa cgt tca     1456
 Leu Lys Arg Leu Glu Ala Val Lys Pro Thr Val Gly Met Lys Arg Ser
         445                 450                 455

 gaa caa ctg atg gac tat cat cgc aat atg ggc tat ctc aac tca tca     1504
 Glu Gln Leu Met Asp Tyr His Arg Asn Met Gly Tyr Leu Asn Ser Ser
     460                 465                 470

 cca ttg tca aga cgg gcc aga tcc act ctt ggc caa tat agc cca tta     1552
 Pro Leu Ser Arg Arg Ala Arg Ser Thr Leu Gly Gln Tyr Ser Pro Leu
 475                 480                 485                 490

 aga gct tcc agg aca tcc agt gct acg agt ggt ctc agt tgt agg agt     1600
 Arg Ala Ser Arg Thr Ser Ser Ala Thr Ser Gly Leu Ser Cys Arg Ser
                 495                 500                 505

 gag cga tca gcg gtt gac ccc tcc agt ggc cac cct cga aga aga cct     1648
 Glu Arg Ser Ala Val Asp Pro Ser Ser Gly His Pro Arg Arg Arg Pro
             510                 515                 520

 aaa ccc cct aat gtc cgt aca gct tgg tta taa aacacttt tttactttaa     1699
 Lys Pro Pro Asn Val Arg Thr Ala Trp Leu 
         525                 530

 acattgttca cacaactttt cttgaagtgc tcgtgcatat tcctataatt ctctgtgtaa   1759

 acatctagaa taccgtttta gcaattgaag gtgtacaaca gtgagttgta atgtattgtt   1819

 attcagtgca aaattattgt caaaaaacga tttaatgtaa aaagtgtttc ctgaggatgt   1879

 atttatatga gatgtatgtg ttcttaatag agaaatagtg gtatgcatgt gtatcttcta   1939

 attattcagt tgtcatgctg tcaaaatagt agtgatagta tcattgcatg tcgtacccaa   1999

 gatggtcact atagttttca atttgtgtta ttttcatttc tttataagtg ttataccatg   2059

 agctcagctc ctaaatttgg ctggctttgt ttttcatttg ctttagaact tatgtggcat   2119

 gacatagctc gattgtatga gatttaacac ttattatgaa acaaatcttg aaatttgttt   2179

 tcactggtag agctgatcta gatttgatga gcagattgag agacgcttct attggagcaa   2239

 ttcttgtaat tcaccagagg tatctagttg ttgtataagt gcactgagtt agatcttaaa   2299

 agtttgatca atcattccaa accatttcaa atatgaatat tagaaagttc aacttagaag   2359

 cttccctttt gtgttttcat gcattcaggt aaagtcctat ttatgactct tagaaatgag   2419

 gtaggtttta gagctagtct tctaactcgt gaatagttta aggaccacat cagttgcaaa   2479

 ccaagtattt gttgaatcag taaaatggca ctatcagcat gaagagccga gaagcagatc   2539

 ctgaggtgtg tcggacagtg ttttaggtaa ttcagtattt attatgttat tagagaagac   2599

 ttagcgtaag aaagaaatgc tttagaaatt ccagcaagta tttataaggc ctgaaaaaac   2659

 taaaatttga acaaaaaggg aaataaatca cacatttgtt gaggctgctg ctttaagtat   2719

 tagctaattt tcttgttttg gtttactttg atttatttga ttgaaccctg gaagtattat   2779

 ttttaccagt cccacattta aagacctagt aatcttgatg gaattggtaa tggcagatag   2839

 ggtttaatgt tgttgacttt tcaaattaga attttttttc tatgaaactt aggcttttat   2899

 ataacaaagt atgttatctc attgttaccg ccgtttttca ctactagcct tttcagtatg   2959

 cccttaaaat gtattggaaa ggttccatgt taaatgacaa atatcttttt cagtatgaat   3019

 ttttgatctg tagccacaat aagattttca tttttcagtg ctcaggctct gtagcatgta   3079

 tgctgaatgc ttttttcctt agcaccttta acagtaaggt gttactgcat tttacaaaac   3139

 atcaattcaa catgtcttgg atttagtttg tattcataga ttttgttaag gatcaggcct   3199

 gtgaacatgg gcacagtgag gttaaataat tcacctggcc acaacctggc tttgaggttc   3259

 tgcttttggg ggccataatt ttcattcaat gttattcgat gctctgttct ggtgaacaag   3319

 ttactatacc tgctgtgtat ataagcttga gctatactaa accaaggctt tattttcttt   3379

 tgttttttaa cttactgtac ttttactgtt tatataacct atatttcaag agagagaaga   3439

 taatgctgaa ttttaaattt agcatttgaa catctgtcca atagtgaatt aatcagtttt   3499

 tttaaaattg atttttaagt tgttccagaa aaaaatatat atatatgttt tatatatata   3559

 gtctttttat atatataaaa aatctttttt ataaatttta ttttaaaaat cttttaagaa   3619

 ggatttttat atatatataa agactatata tttatatata gtcttttctg ttcataatgg   3679

 cattagtctc tgagtacatt ttatattatc tttgttgcta catgtcagga tacaacacaa   3739

 tagttttata aataacaact gtactttgat tttaggtact aatttaatgc tttagttttt   3799

 actactttga agggaggttc atctaagtat tactgataac agggatccaa cttaaagtaa   3859

 aagttggaaa gggcaagagt cttttaagcg gaacttcaat tctgttgtca tggttactta   3919

 tatataatga atataaatag acaaatagga cttggaaaat gtggtatatt ctaagtcaag   3979

 atgctatgaa gttgttatag tttaagggac attcttaaga aggaattact taagtacatt   4039

 actcttctca ttttcaagga catgaaaaag taaaggatgg tctggcacta ttttatttta   4099

 tttttttttg acttgtactg aatatatgta ctttgaagat ttacatctat aactagaaag   4159

 tatgctaatc cgaggtctgg ttattaggcc agattcttgt tcagttattt tttaaactaa   4219

 tgttgcctcc tttttagtaa gattctacga aagtttttta actattaaag ttatttctta   4279

 aggggtagct cttatacttc ctctgctctc tttttcagtt tccataaaaa gctgttttct   4339

 tagctattac tccaaataaa gttctttggt ttgcttaaaa aaaaaaaa                4387




      <210> 245
      <211> 1628
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1098)

      <400> 245
 gagggggcgg ggttgtgagc aaatcttggt ggtggtggtg gtggggcggc ctgagaagat     60

 att  atg gct gct gcc acg gag cat aat cgc ccg agc agc ggt gac agg     108
      Met Ala Ala Ala Thr Glu His Asn Arg Pro Ser Ser Gly Asp Arg
        1               5                  10                  15

 aac ctg gag cga aga tgc agc ccc aac ctc tcc cga gag gtg ctc tac      156
 Asn Leu Glu Arg Arg Cys Ser Pro Asn Leu Ser Arg Glu Val Leu Tyr
                  20                  25                  30

 gaa atc ttt cgc tcc cta cac acc ctg gtt gga cag ctt gac ctc aga      204
 Glu Ile Phe Arg Ser Leu His Thr Leu Val Gly Gln Leu Asp Leu Arg
              35                  40                  45

 gat gat gtg gtg aaa att aca atc gat tgg aac aag ctc cag agc ctc      252
 Asp Asp Val Val Lys Ile Thr Ile Asp Trp Asn Lys Leu Gln Ser Leu
          50                  55                  60

 tcg gca ttc cag cct gca ttg ctc ttt agt gca ctt gaa caa cac att      300
 Ser Ala Phe Gln Pro Ala Leu Leu Phe Ser Ala Leu Glu Gln His Ile
      65                  70                  75

 tta tat tta cag cct ttt tta gca aaa ctt cag tct ccg att aaa gag      348
 Leu Tyr Leu Gln Pro Phe Leu Ala Lys Leu Gln Ser Pro Ile Lys Glu
  80                  85                  90                  95

 gag aat aca act gct gtt gaa gag ata gga aga aca gaa atg ggg aac      396
 Glu Asn Thr Thr Ala Val Glu Glu Ile Gly Arg Thr Glu Met Gly Asn
                 100                 105                 110

 aaa aat gaa gta aat gac aaa ttt tcc att ggc gac cta caa gag gaa      444
 Lys Asn Glu Val Asn Asp Lys Phe Ser Ile Gly Asp Leu Gln Glu Glu
             115                 120                 125

 gaa aag cac aaa gaa agt gat tta aga gat gtg aaa aag aca cag atc      492
 Glu Lys His Lys Glu Ser Asp Leu Arg Asp Val Lys Lys Thr Gln Ile
         130                 135                 140

 cat ttt gat cca gaa gta gtt cag ata aag gct gga aaa gca gaa att      540
 His Phe Asp Pro Glu Val Val Gln Ile Lys Ala Gly Lys Ala Glu Ile
     145                 150                 155

 gac aga cga ata tct gca ttt att gaa aga aag caa gct gaa atc aat      588
 Asp Arg Arg Ile Ser Ala Phe Ile Glu Arg Lys Gln Ala Glu Ile Asn
 160                 165                 170                 175

 gaa aac aac gtc agg gaa ttt tgc aat gtt att gat tgt aat caa gaa      636
 Glu Asn Asn Val Arg Glu Phe Cys Asn Val Ile Asp Cys Asn Gln Glu
                 180                 185                 190

 aat agt tgt gca aga act gat gcg att ttt acc cct tac ccc gga ttt      684
 Asn Ser Cys Ala Arg Thr Asp Ala Ile Phe Thr Pro Tyr Pro Gly Phe
             195                 200                 205

 aaa agt cac gta aaa gtt tct aga gtt gtg aat aca tac gga cca cag      732
 Lys Ser His Val Lys Val Ser Arg Val Val Asn Thr Tyr Gly Pro Gln
         210                 215                 220

 act aga cct gaa gga att cca ggg tca ggt cat aaa cct aac agc atg      780
 Thr Arg Pro Glu Gly Ile Pro Gly Ser Gly His Lys Pro Asn Ser Met
     225                 230                 235

 ctt cga gac tgt ggt aat cag gct gta gaa gaa cga cta caa aat att      828
 Leu Arg Asp Cys Gly Asn Gln Ala Val Glu Glu Arg Leu Gln Asn Ile
 240                 245                 250                 255

 gag gcc cac ttg cgg tta cag aca ggt ggt cca gtg cca aga gac att      876
 Glu Ala His Leu Arg Leu Gln Thr Gly Gly Pro Val Pro Arg Asp Ile
                 260                 265                 270

 tat cag aga att aaa aaa ctt gag gat aaa atc ctt gaa ttg gaa ggc      924
 Tyr Gln Arg Ile Lys Lys Leu Glu Asp Lys Ile Leu Glu Leu Glu Gly
             275                 280                 285

 atc tct cct gaa tat ttt cag tct gta agc ttt tct gga aaa aga aga      972
 Ile Ser Pro Glu Tyr Phe Gln Ser Val Ser Phe Ser Gly Lys Arg Arg
         290                 295                 300

 aaa gtt caa cca cct caa cag aac tat tca ctg gct gaa ctt gat gag     1020
 Lys Val Gln Pro Pro Gln Gln Asn Tyr Ser Leu Ala Glu Leu Asp Glu
     305                 310                 315

 aaa att agt gcc ctc aaa caa gcc ctc ctc aga aaa tca aga gaa gca     1068
 Lys Ile Ser Ala Leu Lys Gln Ala Leu Leu Arg Lys Ser Arg Glu Ala
 320                 325                 330                 335

 gaa tcc atg gca acc cac cac ctt cca tga a aaactcctct cgtccttgtc     1119
 Glu Ser Met Ala Thr His His Leu Pro 
                 340

 attttacttt tttgtataca tatgtgtaac ttacactgtt attaattcaa cggatatata   1179

 tttatcaatg tagacttctc tgtgaagtca aggtttattt tcacatgagt ccagcttgca   1239

 gcaagtaatc ttcaaatatt ccagtaagtt ttgaaataat gaatgcattg aaaatagcat   1299

 tgttggaatt tattcccttc tgttttaaag gaggtatttt ggaaattgaa aaacttaatt   1359

 tacaagtgct ggtacatctt ttttcttttg tggaccacag gaaggaagat ttattttgat   1419

 attgatactt taaaaggact ttatatttgt aacattgatg ttaaccagtt tattagttta   1479

 aatcagtact ttgcatataa taagcattca acaaaaattt attgactgaa atgaatttta   1539

 aatgcatgtg tatgaacttg tttttcttaa tctttaagat gtcagtattc atgtaaataa   1599

 acaatagatc cagctttaaa aaaaaaaaa                                     1628




      <210> 246
      <211> 1519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1418)

      <400> 246
 ctcagcttcc cagcccagct ggggcaccca ctggaaggag aggccaggcg gaagaccctg     60

 gctccgtc atg gcc tct gcc ctg agg cca ccc cgt gtc ccc aag cct aag     110
          Met Ala Ser Ala Leu Arg Pro Pro Arg Val Pro Lys Pro Lys
            1               5                  10

 ggt gtc ctg cct tca cac tac tat gag agc ttt cta gag aag aag ggg      158
 Gly Val Leu Pro Ser His Tyr Tyr Glu Ser Phe Leu Glu Lys Lys Gly
  15                  20                  25                  30

 ccc tgt gac cgg gat tac aag aag ttc tgg gca ggc ctg cag ggt ctc      206
 Pro Cys Asp Arg Asp Tyr Lys Lys Phe Trp Ala Gly Leu Gln Gly Leu
                  35                  40                  45

 acc att tat ttc tac aat agc aat cgg gac ttc cag cac gtg gag aag      254
 Thr Ile Tyr Phe Tyr Asn Ser Asn Arg Asp Phe Gln His Val Glu Lys
              50                  55                  60

 ctc aac ttg gga gca ttt gag aaa ctc aca gat gag att ccc tgg gga      302
 Leu Asn Leu Gly Ala Phe Glu Lys Leu Thr Asp Glu Ile Pro Trp Gly
          65                  70                  75

 agc tca cgt gac cct ggc act cac ttc agc ctg att ctc cgg aat cag      350
 Ser Ser Arg Asp Pro Gly Thr His Phe Ser Leu Ile Leu Arg Asn Gln
      80                  85                  90

 gag atc aag ttc aag gta gag acc ttg gag tgt cgg gaa atg tgg aaa      398
 Glu Ile Lys Phe Lys Val Glu Thr Leu Glu Cys Arg Glu Met Trp Lys
  95                 100                 105                 110

 ggc ttc atc tta acg gtg gtg gag ctc cgt gtc ccg acc gac ttg acc      446
 Gly Phe Ile Leu Thr Val Val Glu Leu Arg Val Pro Thr Asp Leu Thr
                 115                 120                 125

 ctg ctt cct ggg cac cta tac atg atg tct gaa gtc ttg gcc aaa gag      494
 Leu Leu Pro Gly His Leu Tyr Met Met Ser Glu Val Leu Ala Lys Glu
             130                 135                 140

 gag gcg cgc cgt gca ctg gag aca ccc tcg tgc ttc ctg aag gtg agc      542
 Glu Ala Arg Arg Ala Leu Glu Thr Pro Ser Cys Phe Leu Lys Val Ser
         145                 150                 155

 cgg ctg gag gca caa ctg ctc ctg gag cgc tac ccc gag tgc ggg aac      590
 Arg Leu Glu Ala Gln Leu Leu Leu Glu Arg Tyr Pro Glu Cys Gly Asn
     160                 165                 170

 ctg ctg ctg cgg ccc agc ggg gac ggc gcc gac ggc gtg tcg gtc acc      638
 Leu Leu Leu Arg Pro Ser Gly Asp Gly Ala Asp Gly Val Ser Val Thr
 175                 180                 185                 190

 acg cgg cag atg cac aac ggg acg cac gtg gtc cgg cat tac aag gtg      686
 Thr Arg Gln Met His Asn Gly Thr His Val Val Arg His Tyr Lys Val
                 195                 200                 205

 aag cgg gag ggc ccc aag tac gtg atc gat gtg gaa cag ccg ttc tct      734
 Lys Arg Glu Gly Pro Lys Tyr Val Ile Asp Val Glu Gln Pro Phe Ser
             210                 215                 220

 tgc acc tcc ctg gac gcc gtg gtc aac tat ttc gtg tcg cat acc aaa      782
 Cys Thr Ser Leu Asp Ala Val Val Asn Tyr Phe Val Ser His Thr Lys
         225                 230                 235

 aag gcg ctg gtg cca ttc ctg tta gac gag gac tac gag aag gtg cta      830
 Lys Ala Leu Val Pro Phe Leu Leu Asp Glu Asp Tyr Glu Lys Val Leu
     240                 245                 250

 ggc tac gtg gaa gcc gat aag gag aat ggc gag aat gtg tgg gtg gcg      878
 Gly Tyr Val Glu Ala Asp Lys Glu Asn Gly Glu Asn Val Trp Val Ala
 255                 260                 265                 270

 ccc tcc gct ccg ggc cca ggt cct gca ccc tgc aca ggt ggc ccc aag      926
 Pro Ser Ala Pro Gly Pro Gly Pro Ala Pro Cys Thr Gly Gly Pro Lys
                 275                 280                 285

 ccg ctg tca cct gcg tct agc cag gac aag ctg ccc cca ctg ccc cca      974
 Pro Leu Ser Pro Ala Ser Ser Gln Asp Lys Leu Pro Pro Leu Pro Pro
             290                 295                 300

 cta ccg aac cag gaa gag aac tac gtg acc cct att gga gat ggc cca     1022
 Leu Pro Asn Gln Glu Glu Asn Tyr Val Thr Pro Ile Gly Asp Gly Pro
         305                 310                 315

 gct gtt gac tat gag aac caa gat gtg gct tcc tct agt tgg cca gtc     1070
 Ala Val Asp Tyr Glu Asn Gln Asp Val Ala Ser Ser Ser Trp Pro Val
     320                 325                 330

 atc ctg aag cca aag aag ttg cca aag cct cct gcc aag ctt cca aag     1118
 Ile Leu Lys Pro Lys Lys Leu Pro Lys Pro Pro Ala Lys Leu Pro Lys
 335                 340                 345                 350

 cca ccc gtt gga ccc aag cca gta gag aag ggg ttt cac cat gtt gcc     1166
 Pro Pro Val Gly Pro Lys Pro Val Glu Lys Gly Phe His His Val Ala
                 355                 360                 365

 cag gct ggt ctc gaa ctc ctg acc tca agt gat cca ccc acc tca gcc     1214
 Gln Ala Gly Leu Glu Leu Leu Thr Ser Ser Asp Pro Pro Thr Ser Ala
             370                 375                 380

 tcc caa agt gct ggg att acc ggc gtg agc cac cac acc tgg cct cat     1262
 Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His His Thr Trp Pro His
         385                 390                 395

 ctg tct tct ctt cca gag ccc aaa gtc ttt aat ggt ggc ttg ggc agg     1310
 Leu Ser Ser Leu Pro Glu Pro Lys Val Phe Asn Gly Gly Leu Gly Arg
     400                 405                 410

 aag ctg cca gtc agt tca gcc cag cct ctc ttc ccc aca gcc ggg ctg     1358
 Lys Leu Pro Val Ser Ser Ala Gln Pro Leu Phe Pro Thr Ala Gly Leu
 415                 420                 425                 430

 gca gac atg acg gca gag cta cag aag aag ctg gag aag agg cgg gca     1406
 Ala Asp Met Thr Ala Glu Leu Gln Lys Lys Leu Glu Lys Arg Arg Ala
                 435                 440                 445

 ctg gag cac tga ttc ggacacacca gggaccagcg ggctagtccc agggcatggc     1461
 Leu Glu His 


 ccagcggcca gattcttttt cccaggatta aaactctgac cccaggaaaa aaaaaaaa     1519




      <210> 247
      <211> 1381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1280)

      <400> 247
 ctcagcttcc cagcccagct ggggcaccca ctggaaggag aggccaggcg gaagaccctg     60

 gctccgtc atg gcc tct gcc ctg agg cca ccc cgt gtc ccc aag cct aag     110
          Met Ala Ser Ala Leu Arg Pro Pro Arg Val Pro Lys Pro Lys
            1               5                  10

 ggt gtc ctg cct tca cac tac tat gag agc ttt cta gag aag aag ggg      158
 Gly Val Leu Pro Ser His Tyr Tyr Glu Ser Phe Leu Glu Lys Lys Gly
  15                  20                  25                  30

 ccc tgt gac cgg gat tac aag aag ttc tgg gca ggc ctg cag ggt ctc      206
 Pro Cys Asp Arg Asp Tyr Lys Lys Phe Trp Ala Gly Leu Gln Gly Leu
                  35                  40                  45

 acc att tat ttc tac aat agc aat cgg gac ttc cag cac gtg gag aag      254
 Thr Ile Tyr Phe Tyr Asn Ser Asn Arg Asp Phe Gln His Val Glu Lys
              50                  55                  60

 ctc aac ttg gga gca ttt gag aaa ctc aca gat gag att ccc tgg gga      302
 Leu Asn Leu Gly Ala Phe Glu Lys Leu Thr Asp Glu Ile Pro Trp Gly
          65                  70                  75

 agc tca cgt gac cct ggc act cac ttc agc ctg att ctc cgg aat cag      350
 Ser Ser Arg Asp Pro Gly Thr His Phe Ser Leu Ile Leu Arg Asn Gln
      80                  85                  90

 gag atc aag ttc aag gta gag acc ttg gag tgt cgg gaa atg tgg aaa      398
 Glu Ile Lys Phe Lys Val Glu Thr Leu Glu Cys Arg Glu Met Trp Lys
  95                 100                 105                 110

 ggc ttc atc tta acg gtg gtg gag ctc cgt gtc ccg acc gac ttg acc      446
 Gly Phe Ile Leu Thr Val Val Glu Leu Arg Val Pro Thr Asp Leu Thr
                 115                 120                 125

 ctg ctt cct ggg cac cta tac atg atg tct gaa gtc ttg gcc aaa gag      494
 Leu Leu Pro Gly His Leu Tyr Met Met Ser Glu Val Leu Ala Lys Glu
             130                 135                 140

 gag gcg cgc cgt gca ctg gag aca ccc tcg tgc ttc ctg aag gtg agc      542
 Glu Ala Arg Arg Ala Leu Glu Thr Pro Ser Cys Phe Leu Lys Val Ser
         145                 150                 155

 cgg ctg gag gca caa ctg ctc ctg gag cgc tac ccc gag tgc ggg aac      590
 Arg Leu Glu Ala Gln Leu Leu Leu Glu Arg Tyr Pro Glu Cys Gly Asn
     160                 165                 170

 ctg ctg ctg cgg ccc agc ggg gac ggc gcc gac ggc gtg tcg gtc acc      638
 Leu Leu Leu Arg Pro Ser Gly Asp Gly Ala Asp Gly Val Ser Val Thr
 175                 180                 185                 190

 acg cgg cag atg cac aac ggg acg cac gtg gtc cgg cat tac aag gtg      686
 Thr Arg Gln Met His Asn Gly Thr His Val Val Arg His Tyr Lys Val
                 195                 200                 205

 aag cgg gag ggc ccc aag tac gtg atc gat gtg gaa cag ccg ttc tct      734
 Lys Arg Glu Gly Pro Lys Tyr Val Ile Asp Val Glu Gln Pro Phe Ser
             210                 215                 220

 tgc acc tcc ctg gac gcc gtg gtc aac tat ttc gtg tcg cat acc aaa      782
 Cys Thr Ser Leu Asp Ala Val Val Asn Tyr Phe Val Ser His Thr Lys
         225                 230                 235

 aag gcg ctg gtg cca ttc ctg tta gac gag gac tac gag aag gtg cta      830
 Lys Ala Leu Val Pro Phe Leu Leu Asp Glu Asp Tyr Glu Lys Val Leu
     240                 245                 250

 ggc tac gtg gaa gcc gat aag gag aat ggc gag aat gtg tgg gtg gcg      878
 Gly Tyr Val Glu Ala Asp Lys Glu Asn Gly Glu Asn Val Trp Val Ala
 255                 260                 265                 270

 ccc tcc gct ccg ggc cca ggt cct gca ccc tgc aca ggt ggc ccc aag      926
 Pro Ser Ala Pro Gly Pro Gly Pro Ala Pro Cys Thr Gly Gly Pro Lys
                 275                 280                 285

 ccg ctg tca cct gcg tct agc cag gac aag ctg ccc cca ctg ccc cca      974
 Pro Leu Ser Pro Ala Ser Ser Gln Asp Lys Leu Pro Pro Leu Pro Pro
             290                 295                 300

 cta ccg aac cag gaa gag aac tac gtg acc cct att gga gat ggc cca     1022
 Leu Pro Asn Gln Glu Glu Asn Tyr Val Thr Pro Ile Gly Asp Gly Pro
         305                 310                 315

 gct gtt gac tat gag aac caa gat gtg gct tcc tct agt tgg cca gtc     1070
 Ala Val Asp Tyr Glu Asn Gln Asp Val Ala Ser Ser Ser Trp Pro Val
     320                 325                 330

 atc ctg aag cca aag aag ttg cca aag cct cct gcc aag ctt cca aag     1118
 Ile Leu Lys Pro Lys Lys Leu Pro Lys Pro Pro Ala Lys Leu Pro Lys
 335                 340                 345                 350

 cca ccc gtt gga ccc aag cca gag ccc aaa gtc ttt aat ggt ggc ttg     1166
 Pro Pro Val Gly Pro Lys Pro Glu Pro Lys Val Phe Asn Gly Gly Leu
                 355                 360                 365

 ggc agg aag ctg cca gtc agt tca gcc cag cct ctc ttc ccc aca gcc     1214
 Gly Arg Lys Leu Pro Val Ser Ser Ala Gln Pro Leu Phe Pro Thr Ala
             370                 375                 380

 ggg ctg gca gac atg acg gca gag cta cag aag aag ctg gag aag agg     1262
 Gly Leu Ala Asp Met Thr Ala Glu Leu Gln Lys Lys Leu Glu Lys Arg
         385                 390                 395

 cgg gca ctg gag cac tga ttcgga cacaccaggg accagcgggc tagtcccagg     1316
 Arg Ala Leu Glu His 
     400

 gcatggccca gcggccagat tctttttccc aggattaaaa ctctgacccc aggaaaaaaa   1376

 aaaaa                                                               1381




      <210> 248
      <211> 1517
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(1187)

      <400> 248
 cccggtcgac gatttcgtcg ctcacgctgg cggcccggcc cgcgcctatc cccggccttg     60

 gccccggacc cgagtgtttc acagccaatg gtgcggatta taggggaaca cagaactgga    120

 cagcactaca aggcgggaag ccatgtctgt tttggaacga gactttccag catccataca    180

 acactctgaa ataccccaac ggggaggggg gcctgggtga gcacaactat tgcagaaatc    240

 cagatggaga cgtgagcccc tggtgctatg tggcagagca cgaggatggt gtctactgga    300

 agtactgtga gatacctgct tgccag atg cct gga aac ctt ggc tgc tac aag     353
                              Met Pro Gly Asn Leu Gly Cys Tyr Lys
                                1               5

 gat cat gga aac cca cct cct cta act ggc acc agt aaa acg tcc aac      401
 Asp His Gly Asn Pro Pro Pro Leu Thr Gly Thr Ser Lys Thr Ser Asn
  10                  15                  20                  25

 aaa ctc acc ata caa act tgc atc agt ttt tgt cgg agt cag agg ttc      449
 Lys Leu Thr Ile Gln Thr Cys Ile Ser Phe Cys Arg Ser Gln Arg Phe
                  30                  35                  40

 aag ttt gct ggg atg gag tca ggc tat gct tgc ttc tgt gga aac aat      497
 Lys Phe Ala Gly Met Glu Ser Gly Tyr Ala Cys Phe Cys Gly Asn Asn
              45                  50                  55

 cct gat tac tgg aag tac ggg gag gca gcc agt acc gaa tgc aac agc      545
 Pro Asp Tyr Trp Lys Tyr Gly Glu Ala Ala Ser Thr Glu Cys Asn Ser
          60                  65                  70

 gtc tgc ttc ggg gat cac acc caa ccc tgt ggt ggc gat ggc agg atc      593
 Val Cys Phe Gly Asp His Thr Gln Pro Cys Gly Gly Asp Gly Arg Ile
      75                  80                  85

 atc ctc ttt gat act ctc gtg ggc gcc tgc ggt ggg aac tac tca gcc      641
 Ile Leu Phe Asp Thr Leu Val Gly Ala Cys Gly Gly Asn Tyr Ser Ala
  90                  95                 100                 105

 atg tct tct gtg gtc tat tcc cct gac ttc ccc gac acc tat gcc acg      689
 Met Ser Ser Val Val Tyr Ser Pro Asp Phe Pro Asp Thr Tyr Ala Thr
                 110                 115                 120

 ggg agg gtc tgc tac tgg acc atc cgg gtt ccg ggg gcc tcc cac atc      737
 Gly Arg Val Cys Tyr Trp Thr Ile Arg Val Pro Gly Ala Ser His Ile
             125                 130                 135

 cac ttc agc ttc ccc cta ttt gac atc agg gac tcg gcg gac atg gtg      785
 His Phe Ser Phe Pro Leu Phe Asp Ile Arg Asp Ser Ala Asp Met Val
         140                 145                 150

 gag ctt ctg gat ggc tac acc cac cgt gtc cta gcc cgc ttc cac ggg      833
 Glu Leu Leu Asp Gly Tyr Thr His Arg Val Leu Ala Arg Phe His Gly
     155                 160                 165

 agg agc cgc cca cct ctg tcc ttc aac gtc tct ctg gac ttc gtc atc      881
 Arg Ser Arg Pro Pro Leu Ser Phe Asn Val Ser Leu Asp Phe Val Ile
 170                 175                 180                 185

 ttg tat ttc ttc tct gat cgc atc aat cag gcc cag gga ttt gct gtt      929
 Leu Tyr Phe Phe Ser Asp Arg Ile Asn Gln Ala Gln Gly Phe Ala Val
                 190                 195                 200

 tta tac caa gcc gtc aag gaa gaa ctg cca cag gag agg ccc gct gtc      977
 Leu Tyr Gln Ala Val Lys Glu Glu Leu Pro Gln Glu Arg Pro Ala Val
             205                 210                 215

 aac cag acg gtg gcc gag gtg atc acg gag cag gcc aac ctc agt gtc     1025
 Asn Gln Thr Val Ala Glu Val Ile Thr Glu Gln Ala Asn Leu Ser Val
         220                 225                 230

 agc gct gcc cgg tcc tcc aaa gtc ctc tat gtc atc acc acc agc ccc     1073
 Ser Ala Ala Arg Ser Ser Lys Val Leu Tyr Val Ile Thr Thr Ser Pro
     235                 240                 245

 agc cac cca cct cag act gtc cca gga tgg aca gtc tat ggt ctg gca     1121
 Ser His Pro Pro Gln Thr Val Pro Gly Trp Thr Val Tyr Gly Leu Ala
 250                 255                 260                 265

 act ctc ctc atc ctc aca gtc aca gcc att gta gca aag ata ctt ctg     1169
 Thr Leu Leu Ile Leu Thr Val Thr Ala Ile Val Ala Lys Ile Leu Leu
                 270                 275                 280

 cac gtc aca ttc aag tga gtacaa gagggagctg cccaattcca ggaaagggaa     1223
 His Val Thr Phe Lys 
             285

 ggctcagagt tcattttcta tgatgcttca tttgtctggt tacaactgta gaataagcac   1283

 atgattccaa agccctcagt cctagggaac ggaaggcagc agacattccc ccttctttgt   1343

 agagtgaaat gtacaactgg acaaatctca ttaaggtttc agggattttg tttgctctgt   1403

 gtccaaggca tacaatttca aggaggattg caacattcct ggcttaaaaa gcaaatgtgc   1463

 tagtccctta cggagatctt tatgcaagac tgaagatagc taggacgatg ccgt         1517




      <210> 249
      <211> 1591
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(1155)

      <400> 249
 cccacgcgtc cgcccacgcg tccgatc    atg gct gct gcc acg gag ctt aat      51
                                  Met Ala Ala Ala Thr Glu Leu Asn
                                    1               5

 cgc ccg agc agc ggt gac agg aac ctg gag cga aga tgc agc ccc aac       99
 Arg Pro Ser Ser Gly Asp Arg Asn Leu Glu Arg Arg Cys Ser Pro Asn
      10                  15                  20

 ctc tcc cga gag gtg ctc tac gaa atc ttt cgc tcc cta cac acc ctg      147
 Leu Ser Arg Glu Val Leu Tyr Glu Ile Phe Arg Ser Leu His Thr Leu
  25                  30                  35                  40

 gtt gga cag ctt gac ctc aga gat gat gtg gtg aaa att aca atc gat      195
 Val Gly Gln Leu Asp Leu Arg Asp Asp Val Val Lys Ile Thr Ile Asp
                  45                  50                  55

 tgg aac aag ctc cag agc ctc tcg gca ttc cag cct gca ttg ctc ttt      243
 Trp Asn Lys Leu Gln Ser Leu Ser Ala Phe Gln Pro Ala Leu Leu Phe
              60                  65                  70

 agt gca ctt gaa caa cac att tta tat tta cag cct ttt tta gca aaa      291
 Ser Ala Leu Glu Gln His Ile Leu Tyr Leu Gln Pro Phe Leu Ala Lys
          75                  80                  85

 ctt cag tct ccg att aaa gag gag aat aca act gct gtt gaa gag ata      339
 Leu Gln Ser Pro Ile Lys Glu Glu Asn Thr Thr Ala Val Glu Glu Ile
      90                  95                 100

 gga aga aca gaa atg ggg aac aaa aat gaa gta aat gac aaa ttt tcc      387
 Gly Arg Thr Glu Met Gly Asn Lys Asn Glu Val Asn Asp Lys Phe Ser
 105                 110                 115                 120

 att ggc gac cta caa gag gaa gaa aag cac aaa gaa agt gat tta aga      435
 Ile Gly Asp Leu Gln Glu Glu Glu Lys His Lys Glu Ser Asp Leu Arg
                 125                 130                 135

 gat gtg aaa aag aca cag atc cat ttt gat cca gaa gta gtt cag ata      483
 Asp Val Lys Lys Thr Gln Ile His Phe Asp Pro Glu Val Val Gln Ile
             140                 145                 150

 aag gct gga aaa gca gaa att gac aga cga ata tct gca ttt att gaa      531
 Lys Ala Gly Lys Ala Glu Ile Asp Arg Arg Ile Ser Ala Phe Ile Glu
         155                 160                 165

 aga aag caa gct gaa atc aat gaa aac aac gtc agg gaa ttt tgc aat      579
 Arg Lys Gln Ala Glu Ile Asn Glu Asn Asn Val Arg Glu Phe Cys Asn
     170                 175                 180

 gtt att gat tgt aat caa gaa aat agt tgt gca aga act gat gcg att      627
 Val Ile Asp Cys Asn Gln Glu Asn Ser Cys Ala Arg Thr Asp Ala Ile
 185                 190                 195                 200

 ttt acc cct tac ccc gga ttt aaa agt cac gta aaa gtt tct aga gtt      675
 Phe Thr Pro Tyr Pro Gly Phe Lys Ser His Val Lys Val Ser Arg Val
                 205                 210                 215

 gtg aat aca tac gga cca cag act aga cct gaa gga att cca ggg tca      723
 Val Asn Thr Tyr Gly Pro Gln Thr Arg Pro Glu Gly Ile Pro Gly Ser
             220                 225                 230

 ggt cat aaa cct aac agc atg ctt cga gac tgt ggt aat cag gct gta      771
 Gly His Lys Pro Asn Ser Met Leu Arg Asp Cys Gly Asn Gln Ala Val
         235                 240                 245

 gaa gaa cga cta caa aat att gag gcc cac ttg cgg tta cag aca ggt      819
 Glu Glu Arg Leu Gln Asn Ile Glu Ala His Leu Arg Leu Gln Thr Gly
     250                 255                 260

 ggt cca gtg cca aga gac att tat cag aga att aaa aaa ctt gag gat      867
 Gly Pro Val Pro Arg Asp Ile Tyr Gln Arg Ile Lys Lys Leu Glu Asp
 265                 270                 275                 280

 aaa atc ctt gaa ttg gaa ggc atc tct cct gaa tat ttt cag tct gta      915
 Lys Ile Leu Glu Leu Glu Gly Ile Ser Pro Glu Tyr Phe Gln Ser Val
                 285                 290                 295

 agc ttt tct gga aaa gaa gaa aag ttc aac cac ctc aac aga act att      963
 Ser Phe Ser Gly Lys Glu Glu Lys Phe Asn His Leu Asn Arg Thr Ile
             300                 305                 310

 cac tgg ctg aac ttg atg aga aaa tta gtg ccc tca aac aag ccc tcc     1011
 His Trp Leu Asn Leu Met Arg Lys Leu Val Pro Ser Asn Lys Pro Ser
         315                 320                 325

 tca gaa aat caa gag aag cag aat cca tgg caa ccc acc acc ttc cat     1059
 Ser Glu Asn Gln Glu Lys Gln Asn Pro Trp Gln Pro Thr Thr Phe His
     330                 335                 340

 gaa aaa ctc ctc tcg tcc ttg tca ttt tac ttt ttt gta tac ata tgt     1107
 Glu Lys Leu Leu Ser Ser Leu Ser Phe Tyr Phe Phe Val Tyr Ile Cys
 345                 350                 355                 360

 gta act tac act gtt att aat tca acg gat ata tat tta tca atg tag     1155
 Val Thr Tyr Thr Val Ile Asn Ser Thr Asp Ile Tyr Leu Ser Met 
                 365                 370                 375

 acttctctgt gaagtcaagg tttattttca catgagtcca gcttgcagca agtaatcttc   1215

 aaatattcca gtaagttttg aaataatgaa tgcattgaaa atagcattgt tggaatttat   1275

 tcccttctgt tttaaaggag gtattttgga aattgaaaaa cttaatttac aagtgctggt   1335

 acatcttttt tcttttgtgg accacaggaa ggaagattta ttttgatatt gatactttaa   1395

 aaggacttta tatttgtaac attgatgtta accagtttat tagtttaaat cagtactttg   1455

 catataataa gcattcaaca aaaatttatt gactgaaatg aattttaaat gcatgtgtat   1515

 gaacttgttt ttcttaatct ttaagatgtc agtattcatg taaataaaca atagatccag   1575

 ctttaaaaaa aaaaaa                                                   1591




      <210> 250
      <211> 2314
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (513)..(1919)

      <400> 250
 ccttcccatt cttttctgaa ggaatcacac ggaaccgaac tgcccaggag aaagtggcag     60

 gcttggagca acaggttctg atgctcacca aggagttaaa gtctcagaag gagctagtga    120

 agatcctgca caaggcactg gaggccgccc agcaggagaa gcgggcgtcc agcgcatacc    180

 tggcggcggc tgaggacaag gaccggctgg agctggtgcg gcacaaagtg cggcagatcg    240

 cggagctggg ccggcgggtg gaggccctgg agcaggagcg ggagagcctg gcgcacacag    300

 cgagcctgcg ggagcagcag gtgcaggagc tacagcagca cgtgcagctg cttatggaca    360

 agaaccacgc caagcagcag gtcatctgca agctctctga gaaggtcacc caggacttca    420

 cgcacccccc tgaccagtct cctttgcgcc ccgacgctgc caacagggac ttcctgagcc    480

 agcaggggaa gatagagcac ctgaaggatg ac  atg gaa gct tac cgg acc cag     533
                                      Met Glu Ala Tyr Arg Thr Gln
                                        1               5

 aac tgc ttc ctc aac tcc gag atc cac cag gtc aca aag atc tgg aga      581
 Asn Cys Phe Leu Asn Ser Glu Ile His Gln Val Thr Lys Ile Trp Arg
          10                  15                  20

 aag gtg gct gag aag gag aag gcc ctt ctg acg aag tgc gcc tac ctc      629
 Lys Val Ala Glu Lys Glu Lys Ala Leu Leu Thr Lys Cys Ala Tyr Leu
      25                  30                  35

 caa gcc aga aac tgc cag gtg gaa agc aag tac ctg gcc ggt ctg aga      677
 Gln Ala Arg Asn Cys Gln Val Glu Ser Lys Tyr Leu Ala Gly Leu Arg
  40                  45                  50                  55

 agg ctg cag gag gcc ctg ggg gac gaa gcc agc gag tgc tca gag ctg      725
 Arg Leu Gln Glu Ala Leu Gly Asp Glu Ala Ser Glu Cys Ser Glu Leu
                  60                  65                  70

 ctg agg cag ctt gtc cag gag gca ctg cag tgg gaa gct ggg gag gcc      773
 Leu Arg Gln Leu Val Gln Glu Ala Leu Gln Trp Glu Ala Gly Glu Ala
              75                  80                  85

 tca tct gac agc atc gag ctg agc ccc atc agt aag tat gat gag tac      821
 Ser Ser Asp Ser Ile Glu Leu Ser Pro Ile Ser Lys Tyr Asp Glu Tyr
          90                  95                 100

 ggc ttc ctg acg gtg ccc gac tat gag gtg gaa gac ctg aag ctg ctg      869
 Gly Phe Leu Thr Val Pro Asp Tyr Glu Val Glu Asp Leu Lys Leu Leu
     105                 110                 115

 gcc aag atc cag gca ttg gag tca cga tcc cac cac ctg ctg ggc ctc      917
 Ala Lys Ile Gln Ala Leu Glu Ser Arg Ser His His Leu Leu Gly Leu
 120                 125                 130                 135

 gag gct gtg gat cgg ccg ctg agg gag cgc tgg gct gcc ctg ggc gat      965
 Glu Ala Val Asp Arg Pro Leu Arg Glu Arg Trp Ala Ala Leu Gly Asp
                 140                 145                 150

 ctt gtg ccc tca gcc gag ctc aag cag cta ctg cgg gca gga gta ccc     1013
 Leu Val Pro Ser Ala Glu Leu Lys Gln Leu Leu Arg Ala Gly Val Pro
             155                 160                 165

 cgt gaa cac cgg cct cgt gtc tgg agg tgg ctg gtc cac ctc cgt gtc     1061
 Arg Glu His Arg Pro Arg Val Trp Arg Trp Leu Val His Leu Arg Val
         170                 175                 180

 cag cac ctg cac act cca ggc tgc tac cag gaa ctg ctg agc cgg ggc     1109
 Gln His Leu His Thr Pro Gly Cys Tyr Gln Glu Leu Leu Ser Arg Gly
     185                 190                 195

 cag gcc cgc gag cac cct gct gcc cgc cag att gag ctg gac ttg aac     1157
 Gln Ala Arg Glu His Pro Ala Ala Arg Gln Ile Glu Leu Asp Leu Asn
 200                 205                 210                 215

 cgg acc ttc ccc aac aac aaa cac ttc acc tgc ccc acc tcc agc ttc     1205
 Arg Thr Phe Pro Asn Asn Lys His Phe Thr Cys Pro Thr Ser Ser Phe
                 220                 225                 230

 ccc gac aag ctc cgc cgg gtg ctg ctg gcc ttc tcc tgg cag aac ccc     1253
 Pro Asp Lys Leu Arg Arg Val Leu Leu Ala Phe Ser Trp Gln Asn Pro
             235                 240                 245

 acc atc ggc tac tgc cag ggc ctg aac agg ctg gcg gcc att gcc ctg     1301
 Thr Ile Gly Tyr Cys Gln Gly Leu Asn Arg Leu Ala Ala Ile Ala Leu
         250                 255                 260

 ctg gtc cta gag gag gag gag agc gcc ttc tgg tgc ctg gtg gcc att     1349
 Leu Val Leu Glu Glu Glu Glu Ser Ala Phe Trp Cys Leu Val Ala Ile
     265                 270                 275

 gtg gag acc atc atg ccc gct gat tac tac tgc aac acg ctg acg gca     1397
 Val Glu Thr Ile Met Pro Ala Asp Tyr Tyr Cys Asn Thr Leu Thr Ala
 280                 285                 290                 295

 tcc cag gtg gac cag cgg gtg ctc cag gac ctg ctc tcg gag aag ctg     1445
 Ser Gln Val Asp Gln Arg Val Leu Gln Asp Leu Leu Ser Glu Lys Leu
                 300                 305                 310

 ccc agg ctg atg gcc cat ctg ggg cag cac cac gtg gat ctc tcc ctc     1493
 Pro Arg Leu Met Ala His Leu Gly Gln His His Val Asp Leu Ser Leu
             315                 320                 325

 gtc acc ttc aac tgg ttc ctc gtg gtc ttt gcg gac agt ctc att agc     1541
 Val Thr Phe Asn Trp Phe Leu Val Val Phe Ala Asp Ser Leu Ile Ser
         330                 335                 340

 aac atc ctc ctt cgg gtc tgg gat gcc ttc ctg tac gag ggg acg aag     1589
 Asn Ile Leu Leu Arg Val Trp Asp Ala Phe Leu Tyr Glu Gly Thr Lys
     345                 350                 355

 gtg gtg ttt cgc tat gcc ttg gcc att ttc aag tac aac gag aag gag     1637
 Val Val Phe Arg Tyr Ala Leu Ala Ile Phe Lys Tyr Asn Glu Lys Glu
 360                 365                 370                 375

 atc ttg agg cta cag aat ggc ctg gaa atc tac cag tac ctg cgc ttc     1685
 Ile Leu Arg Leu Gln Asn Gly Leu Glu Ile Tyr Gln Tyr Leu Arg Phe
                 380                 385                 390

 ttc acc aag acc atc tcc aac agc cgg aag ctg atg aac atc gcc ttc     1733
 Phe Thr Lys Thr Ile Ser Asn Ser Arg Lys Leu Met Asn Ile Ala Phe
             395                 400                 405

 aat gac atg aac ccc ttc cgc atg aaa cag ctg cgg cag ctg cgc atg     1781
 Asn Asp Met Asn Pro Phe Arg Met Lys Gln Leu Arg Gln Leu Arg Met
         410                 415                 420

 gtc cac cgg gag cgg ctg gag gct gag ctg cgg gag ctg gag cag ctt     1829
 Val His Arg Glu Arg Leu Glu Ala Glu Leu Arg Glu Leu Glu Gln Leu
     425                 430                 435

 aag gca gag tac ctg gag agg cgg gca tcc cgg cgc aga gct gtg tcc     1877
 Lys Ala Glu Tyr Leu Glu Arg Arg Ala Ser Arg Arg Arg Ala Val Ser
 440                 445                 450                 455

 gag ggc tgt gcc agc gag gac gag gtg gag ggg gaa gcc tga cttggcc     1926
 Glu Gly Cys Ala Ser Glu Asp Glu Val Glu Gly Glu Ala 
                 460                 465

 acctcccctc cccacagcct tcctcaccct tggctggcag acccactgga ggtcaggcac   1986

 ggaccagtgg cccagccctg ggtgtcccat caccatgtga ccttggacat gtcccttccc   2046

 ctctctggcc ctcagtttcc ccactgggac attgtgtgct gcaaagccat tggttgggct   2106

 acttcttcat aggcacttac ttacccaggg atgccaccct ttcgtcacct cttccacaga   2166

 gcactttggc atgtaaacaa gcaagagcac tgcctctata gggtaacctg gaacattctc   2226

 taggttatat caatataaaa caatgtaaat ggtggaaatc attcataagc tttggaactt   2286

 aaacagttct cagttaaaaa aaaaaaaa                                      2314




      <210> 251
      <211> 1011
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(924)

      <400> 251
 cggacgcgtg ggtcg atg cac ctg ctt ctg ggc gga cgc act tgg cgc gcg      51
                  Met His Leu Leu Leu Gly Gly Arg Thr Trp Arg Ala
                    1               5                  10

 gcg cgg gct gca gac ggc tgc gag gcg ctg ggc aca ggt gtc ctg atg       99
 Ala Arg Ala Ala Asp Gly Cys Glu Ala Leu Gly Thr Gly Val Leu Met
          15                  20                  25

 gca aat ttc aag ggc cac gcg ctt cca ggg agt ttc ttc ctg atc att      147
 Ala Asn Phe Lys Gly His Ala Leu Pro Gly Ser Phe Phe Leu Ile Ile
      30                  35                  40

 ggg ctg tgt tgg tca gtg aag tac ccg ctg aag tac ttt agc cac acg      195
 Gly Leu Cys Trp Ser Val Lys Tyr Pro Leu Lys Tyr Phe Ser His Thr
  45                  50                  55                  60

 cgg aag aac agc cca cta cat tac tat cag cgt ctc gag atc gtc gaa      243
 Arg Lys Asn Ser Pro Leu His Tyr Tyr Gln Arg Leu Glu Ile Val Glu
                  65                  70                  75

 gcc gca att agg act ttg ttt tcc gtc act ggg atc ctg gca gag cag      291
 Ala Ala Ile Arg Thr Leu Phe Ser Val Thr Gly Ile Leu Ala Glu Gln
              80                  85                  90

 ttt gtt ccg gat ggg ccc cac ctg cac ctc tac cat gag aac cac tgg      339
 Phe Val Pro Asp Gly Pro His Leu His Leu Tyr His Glu Asn His Trp
          95                 100                 105

 ata aag tta atg aat tgg cag cac agc acc atg tac cta ttc ttt gca      387
 Ile Lys Leu Met Asn Trp Gln His Ser Thr Met Tyr Leu Phe Phe Ala
     110                 115                 120

 gtc tca gga att gtt gac atg ctc acc tat ctg gtc agc cac gtt ccc      435
 Val Ser Gly Ile Val Asp Met Leu Thr Tyr Leu Val Ser His Val Pro
 125                 130                 135                 140

 ttg ggg gtg gac aga ctg gtt atg gct gtg gca gta ttc atg gaa ggt      483
 Leu Gly Val Asp Arg Leu Val Met Ala Val Ala Val Phe Met Glu Gly
                 145                 150                 155

 ttc ctc ttc tac tac cac gtc cac aac cgg cct ccg ctg gac cag cac      531
 Phe Leu Phe Tyr Tyr His Val His Asn Arg Pro Pro Leu Asp Gln His
             160                 165                 170

 atc cac tca ctc ctg ctg tat gct ctg ttc gga ggg tgt gtt agt atc      579
 Ile His Ser Leu Leu Leu Tyr Ala Leu Phe Gly Gly Cys Val Ser Ile
         175                 180                 185

 tcc cta gag gtg atc ttc cgg gac cac att gtg ctg gaa ctt ttc cga      627
 Ser Leu Glu Val Ile Phe Arg Asp His Ile Val Leu Glu Leu Phe Arg
     190                 195                 200

 acc agt ctc atc att ctt cag gga acc tgg ttc tgg cag att ggg ttt      675
 Thr Ser Leu Ile Ile Leu Gln Gly Thr Trp Phe Trp Gln Ile Gly Phe
 205                 210                 215                 220

 gtg ctg ttc cca cct ttt gga aca ccc gaa tgg gac cag aag gat gat      723
 Val Leu Phe Pro Pro Phe Gly Thr Pro Glu Trp Asp Gln Lys Asp Asp
                 225                 230                 235

 gcc aac ctc atg ttc atc acc atg tgc ttc tgc tgg cac tac ctg gct      771
 Ala Asn Leu Met Phe Ile Thr Met Cys Phe Cys Trp His Tyr Leu Ala
             240                 245                 250

 gcc ctc agc att gtg gcc gtc aac tat ttt ctt gtt tac tgc ctt ttg      819
 Ala Leu Ser Ile Val Ala Val Asn Tyr Phe Leu Val Tyr Cys Leu Leu
         255                 260                 265

 act cgg atg aag aga cac gga agg gga gaa atc att gga att cag aag      867
 Thr Arg Met Lys Arg His Gly Arg Gly Glu Ile Ile Gly Ile Gln Lys
     270                 275                 280

 ctg aat tca gat gac cct tac cag acc gcc ctc ttg agt ggc tca gat      915
 Leu Asn Ser Asp Asp Pro Tyr Gln Thr Ala Leu Leu Ser Gly Ser Asp
 285                 290                 295                 300

 gag gaa tga gccgaca tgcggagggg gcagatgtcc ccctgcccag ctggaatgaa      971
 Glu Glu 


 tggagttcat cccctccccc tgaatgccaa aaaaaaaaaa                         1011




      <210> 252
      <211> 1100
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(987)

      <400> 252
 agtgccgtca gcgctgggag ttgtgaggaa aaacgccaca aaagctggag ctcaaggatc     60

 cttaattaaa ttaatccccc ccccctcccc gagtgccccg acaaggtgga gcccggcggg    120

 cccgcgagtc cgagacctgt cccaggagct ccagctcacg tgacctgtca ctgcctcccg    180

 ccgcctcctg cccgcgcc  atg acc cag ccg gtg ccc cgg ctc tcc gtg ccc     231
                      Met Thr Gln Pro Val Pro Arg Leu Ser Val Pro
                        1               5                  10

 gcc gcg ctg gcc ctg ggc tca gcc gca ctg ggc gcc gcc ttc gcc act      279
 Ala Ala Leu Ala Leu Gly Ser Ala Ala Leu Gly Ala Ala Phe Ala Thr
              15                  20                  25

 ggc ctc ttc ctg ggg agg cgg tgc ccc cca tgg cga ggc cgg cga gag      327
 Gly Leu Phe Leu Gly Arg Arg Cys Pro Pro Trp Arg Gly Arg Arg Glu
          30                  35                  40

 cag tgc ctg ctt ccc ccc gag gac agc cgc ctg tgg cag tat ctt ctg      375
 Gln Cys Leu Leu Pro Pro Glu Asp Ser Arg Leu Trp Gln Tyr Leu Leu
      45                  50                  55

 agc cgc tcc atg cgg gag cac ccg gcg ctg cga agc ctg agg ctg ctg      423
 Ser Arg Ser Met Arg Glu His Pro Ala Leu Arg Ser Leu Arg Leu Leu
  60                  65                  70                  75

 acc ctg gag cag ccg cag ggg gat tct atg atg acc tgc gag cag gcc      471
 Thr Leu Glu Gln Pro Gln Gly Asp Ser Met Met Thr Cys Glu Gln Ala
                  80                  85                  90

 cag ctc ttg gcc aac ctg gcg cgg ctc atc cag gcc aag aag gcg ctg      519
 Gln Leu Leu Ala Asn Leu Ala Arg Leu Ile Gln Ala Lys Lys Ala Leu
              95                 100                 105

 gac ctg ggc acc ttc acg ggc tac tcc gcc ctg gcc ctg gcc ctg gcg      567
 Asp Leu Gly Thr Phe Thr Gly Tyr Ser Ala Leu Ala Leu Ala Leu Ala
         110                 115                 120

 ctg ccc gcg gac ggg cgc gtg gtg acc tgc gag gtg gac gcg cag ccc      615
 Leu Pro Ala Asp Gly Arg Val Val Thr Cys Glu Val Asp Ala Gln Pro
     125                 130                 135

 ccg gag ctg gga cgg ccc ctg tgg agg cag gcc gag gcg gag cac aag      663
 Pro Glu Leu Gly Arg Pro Leu Trp Arg Gln Ala Glu Ala Glu His Lys
 140                 145                 150                 155

 atc gac ctc cgg ctg aag ccc gcc ttg gag acc ctg gac gag ctg ctg      711
 Ile Asp Leu Arg Leu Lys Pro Ala Leu Glu Thr Leu Asp Glu Leu Leu
                 160                 165                 170

 gcg gcg ggc gag gcc ggc acc ttc gac gtg gcc gtg gtg gat gcg gac      759
 Ala Ala Gly Glu Ala Gly Thr Phe Asp Val Ala Val Val Asp Ala Asp
             175                 180                 185

 aag gag aac tgc tcc gcc tac tac gag cgc tgc ctg cag ctg ctg cga      807
 Lys Glu Asn Cys Ser Ala Tyr Tyr Glu Arg Cys Leu Gln Leu Leu Arg
         190                 195                 200

 ccc gga ggc atc ctc gcc gtc ctc aga gtc ctg tgg cgc ggg aag gtg      855
 Pro Gly Gly Ile Leu Ala Val Leu Arg Val Leu Trp Arg Gly Lys Val
     205                 210                 215

 ctg caa cct ccg aaa ggg gac gtg gcg gcc gag tgt gtg cga aac cta      903
 Leu Gln Pro Pro Lys Gly Asp Val Ala Ala Glu Cys Val Arg Asn Leu
 220                 225                 230                 235

 aac gaa cgc atc cgg cgg gac gtc agg gtc tac atc agc ctc ctg ccc      951
 Asn Glu Arg Ile Arg Arg Asp Val Arg Val Tyr Ile Ser Leu Leu Pro
                 240                 245                 250

 ctg ggc gat gga ctc acc ttg gcc ttc aag atc tag ggct ggcccctagt     1001
 Leu Gly Asp Gly Leu Thr Leu Ala Phe Lys Ile 
             255                 260

 gagtgggctc gagggagggt tgcctgggaa ccccaggaat tgaccctgag ttttaaattc   1061

 gaaaataaag tggggctggg acacacgaaa aaaaaaaaa                          1100




      <210> 253
      <211> 1882
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1144)

      <400> 253
 atttggccct cgaggccaag aattcggcat gaggcgaacc aattcctccg ttgcggcccc     60

 cacctgcagt   atg gag tcg tct cgg ggg cgg ccc ggg ccc gag acg gac     109
              Met Glu Ser Ser Arg Gly Arg Pro Gly Pro Glu Thr Asp
                1               5                  10

 ctt ctg gct gta gcg gaa cat cag gcc cta gtc ttt ggc ggc ggg ccg      157
 Leu Leu Ala Val Ala Glu His Gln Ala Leu Val Phe Gly Gly Gly Pro
      15                  20                  25

 ggc cga acg tcc tct gag ccg ccc gca ggc ctc cgg gtg tcc ggg gag      205
 Gly Arg Thr Ser Ser Glu Pro Pro Ala Gly Leu Arg Val Ser Gly Glu
  30                  35                  40                  45

 gaa gag acc gag aac gtt ggg ggc gcg aac cgc cac ccc agg acg tcc      253
 Glu Glu Thr Glu Asn Val Gly Gly Ala Asn Arg His Pro Arg Thr Ser
                  50                  55                  60

 ccg aag acg tca agc tgc ggc gtc gtc cac cgg ccg gaa cgg gag gct      301
 Pro Lys Thr Ser Ser Cys Gly Val Val His Arg Pro Glu Arg Glu Ala
              65                  70                  75

 ctg gag aac gag ccc ggc cct caa ggg acg ctg tct ggg gcc ggg agc      349
 Leu Glu Asn Glu Pro Gly Pro Gln Gly Thr Leu Ser Gly Ala Gly Ser
          80                  85                  90

 cgc agg ggg gcg ccg ggt gca gag cac gaa cct tcc ctg tcc tcc cgg      397
 Arg Arg Gly Ala Pro Gly Ala Glu His Glu Pro Ser Leu Ser Ser Arg
      95                 100                 105

 cac aag aac ccg gcg ccg ccc gag ggc aag ccc tcc tcc ggg agg gac      445
 His Lys Asn Pro Ala Pro Pro Glu Gly Lys Pro Ser Ser Gly Arg Asp
 110                 115                 120                 125

 tgc cgt cga ggg gga cca ggc ggc ggg atg gat gtt gag cag cag gag      493
 Cys Arg Arg Gly Gly Pro Gly Gly Gly Met Asp Val Glu Gln Gln Glu
                 130                 135                 140

 gag gaa gac aac gac gag gag gcg gcc gcg ggc agc aga gcc ggc cgc      541
 Glu Glu Asp Asn Asp Glu Glu Ala Ala Ala Gly Ser Arg Ala Gly Arg
             145                 150                 155

 tcg ttc tcc agc cgt ctt cag gac agc cgc agc ctg gac ggg ctg agc      589
 Ser Phe Ser Ser Arg Leu Gln Asp Ser Arg Ser Leu Asp Gly Leu Ser
         160                 165                 170

 gag gcg tgc ggt ggc gcc ggg tcc tca ggg agt gcc gag tcc ggc gcg      637
 Glu Ala Cys Gly Gly Ala Gly Ser Ser Gly Ser Ala Glu Ser Gly Ala
     175                 180                 185

 ggc ggc gga cgc cgc gcc acc atc tcc agt ccc ctg gag ctc gaa ggc      685
 Gly Gly Gly Arg Arg Ala Thr Ile Ser Ser Pro Leu Glu Leu Glu Gly
 190                 195                 200                 205

 aca gtg agc cgc cac ggc gac ctt acc cac ttt gtc gcc aac aac ctg      733
 Thr Val Ser Arg His Gly Asp Leu Thr His Phe Val Ala Asn Asn Leu
                 210                 215                 220

 caa ctc aag atc cgt ctg agc ggc gcg cct cca ccc ccg cct tct gcc      781
 Gln Leu Lys Ile Arg Leu Ser Gly Ala Pro Pro Pro Pro Pro Ser Ala
             225                 230                 235

 cct gcg cgg ccc tgc cca gcg cct gca ccc aca ccc aca ccg gcc att      829
 Pro Ala Arg Pro Cys Pro Ala Pro Ala Pro Thr Pro Thr Pro Ala Ile
         240                 245                 250

 ccc ccc atc gac ccc gag gtg ctg cgg gat ctg gag cgg ttg agt cgg      877
 Pro Pro Ile Asp Pro Glu Val Leu Arg Asp Leu Glu Arg Leu Ser Arg
     255                 260                 265

 gag ctg gga ggc cgg gtg gac cgt ctg ctt cgc ggt ctg ggt ggc gcg      925
 Glu Leu Gly Gly Arg Val Asp Arg Leu Leu Arg Gly Leu Gly Gly Ala
 270                 275                 280                 285

 gtg cag gag ctg acg gcg ctg agc gtg ggt tgc atc cag acc tac cgc      973
 Val Gln Glu Leu Thr Ala Leu Ser Val Gly Cys Ile Gln Thr Tyr Arg
                 290                 295                 300

 gat gct gtg gac tcc tta ggt gaa gcc gtg gac atg agc atc aag ggc     1021
 Asp Ala Val Asp Ser Leu Gly Glu Ala Val Asp Met Ser Ile Lys Gly
             305                 310                 315

 atg tac acc ctg ctg gcg cgc tgc gag gag ctg gag cgg gct ctg cag     1069
 Met Tyr Thr Leu Leu Ala Arg Cys Glu Glu Leu Glu Arg Ala Leu Gln
         320                 325                 330

 ccg gtt cag ggg ctg gcg cgc caa gtc cgg gat atc cga cgt act ctg     1117
 Pro Val Gln Gly Leu Ala Arg Gln Val Arg Asp Ile Arg Arg Thr Leu
     335                 340                 345

 gag gtg ttg gag gcc ctg tgc aag tga ccagg aggacaggag aggccggtcc     1169
 Glu Val Leu Glu Ala Leu Cys Lys 
 350                 355

 tggccagggc agggcccagc aggaccctaa ggactcttca gggagtcctg gtgggaagtg   1229

 cccactgagg ggaggcctgt gtgttggagg ctcttccaga tgcgttcagc tggcccgtgc   1289

 ccactcgctg ggccttaggc tggtgtatgt ggggaagttc taacggctct cctggtggga   1349

 agggatgttg ctctgcttgt attcagttgg ccatctgtag ctaccctgtt cttcccaact   1409

 ctcctcccta gctagagcac cagccctggg aacacggggc tttaggtctg cttgaaggtg   1469

 aggacgtgac tcccacatgt aatcaggaga aagggacaga ggaagcccca gcccccactg   1529

 tggctatcct gactccagtg gccacatctc aggtgccagg ggctgtggga gcttgtgccg   1589

 tccttggcca aacaccccgc aggcaaagat gcacccctgc tgatggagag ccttctgctt   1649

 ctgccctctg gccctctacc ataccacttc cccagccaga accggcgtgc agctaggagg   1709

 aatgggttgc acggcggagg gggtgaggtg ggaggcgtct cactgctctc agggttcagg   1769

 tagaatgttg ctggttttga agctcacctg ttgtggagtg ttctaatcag ttttggcttt   1829

 ctgagttttt gtggaattaa agtgctgctg ctgcgaaggc taaaaaaaaa aaa          1882




      <210> 254
      <211> 1497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(884)

      <400> 254
 ggcta    atg gcg gtg ccc acg gaa ctg gat gga ggg agt gtt aag gag      47
          Met Ala Val Pro Thr Glu Leu Asp Gly Gly Ser Val Lys Glu
            1               5                  10

 acc gca gcg gaa gag gaa tcg cga gtt ctg gca cct ggc gcc gcc ccg       95
 Thr Ala Ala Glu Glu Glu Ser Arg Val Leu Ala Pro Gly Ala Ala Pro
  15                  20                  25                  30

 ttc gga aat ttt cct cat tat tct cgc ttc cac cct ccg gag caa cgg      143
 Phe Gly Asn Phe Pro His Tyr Ser Arg Phe His Pro Pro Glu Gln Arg
                  35                  40                  45

 ctc cgc ctc ctg ccc ccg gag ctg ctt cga cag ctc ttt cct gag agt      191
 Leu Arg Leu Leu Pro Pro Glu Leu Leu Arg Gln Leu Phe Pro Glu Ser
              50                  55                  60

 ccc gag aac ggg ccg att ctg ggg ctc gac gtg ggg tgt aac tcc ggg      239
 Pro Glu Asn Gly Pro Ile Leu Gly Leu Asp Val Gly Cys Asn Ser Gly
          65                  70                  75

 gat ctg agt gtg gct cta tac aaa cac ttc ctc tcc cta cct gac ggg      287
 Asp Leu Ser Val Ala Leu Tyr Lys His Phe Leu Ser Leu Pro Asp Gly
      80                  85                  90

 gaa acc tgc tca gat gcc tca aga gaa ttc cgt ctc ctc tgc tgc gac      335
 Glu Thr Cys Ser Asp Ala Ser Arg Glu Phe Arg Leu Leu Cys Cys Asp
  95                 100                 105                 110

 ata gat cca gtc ctg gtg aag cga gcc gaa aaa gaa tgt cct ttt cct      383
 Ile Asp Pro Val Leu Val Lys Arg Ala Glu Lys Glu Cys Pro Phe Pro
                 115                 120                 125

 gat gcc ttg act ttt atc acc ctg gac ttc atg aat caa agg acc cgg      431
 Asp Ala Leu Thr Phe Ile Thr Leu Asp Phe Met Asn Gln Arg Thr Arg
             130                 135                 140

 aag gtt ctc ttg agc tct ttc tta agc caa ttt gga cgt tca gtt ttt      479
 Lys Val Leu Leu Ser Ser Phe Leu Ser Gln Phe Gly Arg Ser Val Phe
         145                 150                 155

 gac att ggc ttc tgc atg tca ata acc atg tgg att cat ctg aat cat      527
 Asp Ile Gly Phe Cys Met Ser Ile Thr Met Trp Ile His Leu Asn His
     160                 165                 170

 gga gac cat ggc cta tgg gag ttc ctg gcc cat ctt tcc tcc ctc tgc      575
 Gly Asp His Gly Leu Trp Glu Phe Leu Ala His Leu Ser Ser Leu Cys
 175                 180                 185                 190

 cac tac ctc ctt gtg gag ccc caa ccc tgg aag tgt tac cgg gca gct      623
 His Tyr Leu Leu Val Glu Pro Gln Pro Trp Lys Cys Tyr Arg Ala Ala
                 195                 200                 205

 gca agg cgt ctc cga aag ctg gga ctc cat gat ttt gac cac ttc cac      671
 Ala Arg Arg Leu Arg Lys Leu Gly Leu His Asp Phe Asp His Phe His
             210                 215                 220

 tcc ctt gcc atc cga ggt gac atg ccc aat cag att gtg cag atc ttg      719
 Ser Leu Ala Ile Arg Gly Asp Met Pro Asn Gln Ile Val Gln Ile Leu
         225                 230                 235

 acc cag gat cat ggc atg gaa tta ata tgt tgc ttt ggc aac acc agt      767
 Thr Gln Asp His Gly Met Glu Leu Ile Cys Cys Phe Gly Asn Thr Ser
     240                 245                 250

 tgg gac aga agc ctt ctg ctc ttc agg gca aaa caa acc ata gag act      815
 Trp Asp Arg Ser Leu Leu Leu Phe Arg Ala Lys Gln Thr Ile Glu Thr
 255                 260                 265                 270

 cat cca atc cct gaa tca ctg ata gaa aaa ggg aaa gaa aag aac aga      863
 His Pro Ile Pro Glu Ser Leu Ile Glu Lys Gly Lys Glu Lys Asn Arg
                 275                 280                 285

 tta agt ttc cag aag cag tga ga tgggagggca agaagaccaa gaaagatatt      916
 Leu Ser Phe Gln Lys Gln 
             290

 gaaagggttt tatattgaga attatgttca ttctccttaa ttccttaaca atcaggcagc    976

 cgcaaaacct ggcaggagct tttggtaaaa tgtccaaggc acataattga aagaatcagt   1036

 atctgttccc cattgtttgg aacaaatctt gaggagaatg aatctgtgga gtgatgagct   1096

 aggatatctg gattgagatg gcctaggaaa agtggtcctg gttatgggtt atggagaggg   1156

 ctgcttttgg ggattattta taaagatcag actaggctag tcttaaaata tgtcagttcc   1216

 tgggctctct gaatcctacc tggtttcttc aggcttctgg acttgctagg cctgcctttg   1276

 ggcaaaacct tagtaattca ggtctggaat ggggcttagg aatctatttt ctgttttttt   1336

 gtttgtttgt ttttgcattc ttctattgta atatatacat aaaatttacc attttaaccg   1396

 tttttaagta cagtttttca gaacgtggaa atcccatcaa aaattggatt aaaaaattaa   1456

 aagataaatt gataattttt ttaaccgtta aaaaaaaaaa a                       1497




      <210> 255
      <211> 554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(469)

      <400> 255
 ggcagcc  atg gcg tcc tat ttc gat gaa cac gac tgc gag ccg tcg gac      49
          Met Ala Ser Tyr Phe Asp Glu His Asp Cys Glu Pro Ser Asp
            1               5                  10

 cct gag cag gag acg cga acc aac atg ctg ctg gag ctc gca agg tca       97
 Pro Glu Gln Glu Thr Arg Thr Asn Met Leu Leu Glu Leu Ala Arg Ser
  15                  20                  25                  30

 ctt ttc aat agg atg gac ttt gaa gac ttg ggg ttg gta gta gat tgg      145
 Leu Phe Asn Arg Met Asp Phe Glu Asp Leu Gly Leu Val Val Asp Trp
                  35                  40                  45

 gac cac cac ctg cct cca cca gct gcc aag act gtg gtt gag aac ctc      193
 Asp His His Leu Pro Pro Pro Ala Ala Lys Thr Val Val Glu Asn Leu
              50                  55                  60

 ccc agg aca gtc atc aga ggc tct cag gct gag ctc aag tgc ccc gtg      241
 Pro Arg Thr Val Ile Arg Gly Ser Gln Ala Glu Leu Lys Cys Pro Val
          65                  70                  75

 tgt ctt ttg gaa ttt gag gag gag gag act gcc att gag atg cct tgc      289
 Cys Leu Leu Glu Phe Glu Glu Glu Glu Thr Ala Ile Glu Met Pro Cys
      80                  85                  90

 cat cac ctt ttc cat tcc agc tgc att ctg ccc tgg cta agc aag aca      337
 His His Leu Phe His Ser Ser Cys Ile Leu Pro Trp Leu Ser Lys Thr
  95                 100                 105                 110

 aat tcc tgt ccc ttg tgc cgc tat gag ctg ccc act gat gac gac act      385
 Asn Ser Cys Pro Leu Cys Arg Tyr Glu Leu Pro Thr Asp Asp Asp Thr
                 115                 120                 125

 tat gag gag cac aga cga gat aag gct cga aaa cag cag cag caa cac      433
 Tyr Glu Glu His Arg Arg Asp Lys Ala Arg Lys Gln Gln Gln Gln His
             130                 135                 140

 cga ctg gag aac ctc cat gga gcc atg tac acg tga ggag gttggggctg      483
 Arg Leu Glu Asn Leu His Gly Ala Met Tyr Thr 
         145                 150

 agtgctggcc ctctgcgtct tccttattaa ccttgaatcc tcattaaagg tttctttacc    543

 caaaaaaaaa a                                                         554




      <210> 256
      <211> 3780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (635)..(3733)

      <400> 256
 ggaggtcttg tttccggaag atgttgcaag gctgtggtga aggcaggtgc agcctagcct     60

 cctgctcaag ctacaccctg gccctccacg catgaggccc tgcagaactc tggagatggt    120

 gcctacaagg gcagaaaagg acaagtcggc agccgctgtc ctgagggcac cagctgtggt    180

 gcaggagcca agacctgagg gtggaagtgt cctcttagaa tggggagtgc ccagcaaggt    240

 gtacccgcta ctggtgctat ccagaattcc catctctccc tgctctctgc ctgagctctg    300

 ggccttagct cctccctggg cttggtagag gacaggtgtg aggccctcat gggatgtagg    360

 ctgtctgaga ggggagtgga aagaggaagg ggtgaaggag ctgtctgcca tttgactatg    420

 caaatggcct ttgactcatg ggaccctgtc ctcctcactg ggggcagggt ggagtggagg    480

 gggagctact aggctggtat aaaaatctta cttcctctat tctctgagcc gctgctgccc    540

 ctgtgggaag ggacctcgag tgtgaagcat ccttccctgt agctgctgtc cagtctgccc    600

 gccagaccct ctggagaagc ccctgccccc cagc    atg ggt ttc tgc cgc agc     652
                                          Met Gly Phe Cys Arg Ser
                                            1               5

 gcc ctg cac ccg ctg tct ctc ctg gtg cag gcc atc atg ctg gcc atg      700
 Ala Leu His Pro Leu Ser Leu Leu Val Gln Ala Ile Met Leu Ala Met
              10                  15                  20

 acc ctg gcc ctg ggt acc ttg cct gcc ttc cta ccc tgt gag ctc cag      748
 Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe Leu Pro Cys Glu Leu Gln
          25                  30                  35

 ccc cac ggc ctg gtg aac tgc aac tgg ctg ttc ctg aag tct gtg ccc      796
 Pro His Gly Leu Val Asn Cys Asn Trp Leu Phe Leu Lys Ser Val Pro
      40                  45                  50

 cac ttc tcc atg gca gca ccc cgt ggc aat gtc acc agc ctt tcc ttg      844
 His Phe Ser Met Ala Ala Pro Arg Gly Asn Val Thr Ser Leu Ser Leu
  55                  60                  65                  70

 tcc tcc aac cgc atc cac cac ctc cat gat tct gac ttt gcc cac ctg      892
 Ser Ser Asn Arg Ile His His Leu His Asp Ser Asp Phe Ala His Leu
                  75                  80                  85

 ccc agc ctg cgg cat ctc aac ctc aag tgg aac tgc ccg ccg gtt ggc      940
 Pro Ser Leu Arg His Leu Asn Leu Lys Trp Asn Cys Pro Pro Val Gly
              90                  95                 100

 ctc agc ccc atg cac ttc ccc tgc cac atg acc atc gag ccc agc acc      988
 Leu Ser Pro Met His Phe Pro Cys His Met Thr Ile Glu Pro Ser Thr
         105                 110                 115

 ttc ttg gct gtg ccc acc ctg gaa gag cta aac ctg agc tac aac aac     1036
 Phe Leu Ala Val Pro Thr Leu Glu Glu Leu Asn Leu Ser Tyr Asn Asn
     120                 125                 130

 atc atg act gtg cct gcg ctg ccc aaa tcc ctc ata tcc ctg tcc ctc     1084
 Ile Met Thr Val Pro Ala Leu Pro Lys Ser Leu Ile Ser Leu Ser Leu
 135                 140                 145                 150

 agc cat acc aac atc ctg atg cta gac tct gcc agc ctc gcc ggc ctg     1132
 Ser His Thr Asn Ile Leu Met Leu Asp Ser Ala Ser Leu Ala Gly Leu
                 155                 160                 165

 cat gcc ctg cgc ttc cta ttc atg gac ggc aac tgt tat tac aag aac     1180
 His Ala Leu Arg Phe Leu Phe Met Asp Gly Asn Cys Tyr Tyr Lys Asn
             170                 175                 180

 ccc tgc agg cag gca ctg gag gtg gcc ccg ggt gcc ctc ctt ggc ctg     1228
 Pro Cys Arg Gln Ala Leu Glu Val Ala Pro Gly Ala Leu Leu Gly Leu
         185                 190                 195

 ggc aac ctc acc cac ctg tca ctc aag tac aac aac ctc act gtg gtg     1276
 Gly Asn Leu Thr His Leu Ser Leu Lys Tyr Asn Asn Leu Thr Val Val
     200                 205                 210

 ccc cgc aac ctg cct tcc agc ctg gag tat ctg ctg ttg tcc tac aac     1324
 Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr Leu Leu Leu Ser Tyr Asn
 215                 220                 225                 230

 cgc atc gtc aaa ctg gcg cct gag gac ctg gcc aat ctg acc gcc ctg     1372
 Arg Ile Val Lys Leu Ala Pro Glu Asp Leu Ala Asn Leu Thr Ala Leu
                 235                 240                 245

 cgt gtg ctc gat gtg ggc gga aat tgc cgc cgc tgc gac cac gct ccc     1420
 Arg Val Leu Asp Val Gly Gly Asn Cys Arg Arg Cys Asp His Ala Pro
             250                 255                 260

 aac ccc tgc atg gag tgc cct cgt cac ttc ccc cag cta cat ccc gat     1468
 Asn Pro Cys Met Glu Cys Pro Arg His Phe Pro Gln Leu His Pro Asp
         265                 270                 275

 acc ttc agc cac ctg agc cgt ctt gaa ggc ctg gtg ttg aag gac agt     1516
 Thr Phe Ser His Leu Ser Arg Leu Glu Gly Leu Val Leu Lys Asp Ser
     280                 285                 290

 tct ctc tcc tgg ctg aat gcc agt tgg ttc cgt ggg ctg gga aac ctc     1564
 Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe Arg Gly Leu Gly Asn Leu
 295                 300                 305                 310

 cga gtg ctg gac ctg agt gag aac ttc ctc tac aaa tgc atc act aaa     1612
 Arg Val Leu Asp Leu Ser Glu Asn Phe Leu Tyr Lys Cys Ile Thr Lys
                 315                 320                 325

 acc aag gcc ttc cag ggc cta aca cag ctg cgc aag ctt aac ctg tcc     1660
 Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu Arg Lys Leu Asn Leu Ser
             330                 335                 340

 ttc aat tac caa aag agg gtg tcc ttt gcc cac ctg tct ctg gcc cct     1708
 Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala His Leu Ser Leu Ala Pro
         345                 350                 355

 tcc ttc ggg agc ctg gtc gcc ctg aag gag ctg gac atg cac ggc atc     1756
 Ser Phe Gly Ser Leu Val Ala Leu Lys Glu Leu Asp Met His Gly Ile
     360                 365                 370

 ttc ttc cgc tca ctc gat gag acc acg ctc cgg cca ctg gcc cgc ctg     1804
 Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu Arg Pro Leu Ala Arg Leu
 375                 380                 385                 390

 ccc atg ctc cag act ctg cgt ctg cag atg aac ttc atc aac cag gcc     1852
 Pro Met Leu Gln Thr Leu Arg Leu Gln Met Asn Phe Ile Asn Gln Ala
                 395                 400                 405

 cag ctc ggc atc ttc agg gcc ttc cct ggc ctg cgc tac gtg gac ctg     1900
 Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly Leu Arg Tyr Val Asp Leu
             410                 415                 420

 tcg gac aac cgc atc agc gga gct tcg gag ctg aca gcc acc atg ggg     1948
 Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu Leu Thr Ala Thr Met Gly
         425                 430                 435

 gag gca gat gga ggg gag aag gtc tgg ctg cag cct ggg gac ctt gct     1996
 Glu Ala Asp Gly Gly Glu Lys Val Trp Leu Gln Pro Gly Asp Leu Ala
     440                 445                 450

 ccg gcc cca gtg gac act ccc agc tct gaa gac ttc agg ccc aac tgc     2044
 Pro Ala Pro Val Asp Thr Pro Ser Ser Glu Asp Phe Arg Pro Asn Cys
 455                 460                 465                 470

 agc acc ctc aac ttc acc ttg gat ctg tca cgg aac aac ctg gtg acc     2092
 Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser Arg Asn Asn Leu Val Thr
                 475                 480                 485

 gtg cag ccg gag atg ttt gcc cag ctc tcg cac ctg cag tgc ctg cgc     2140
 Val Gln Pro Glu Met Phe Ala Gln Leu Ser His Leu Gln Cys Leu Arg
             490                 495                 500

 ctg agc cac aac tgc atc tcg cag gca gtc aat ggc tcc cag ttc ctg     2188
 Leu Ser His Asn Cys Ile Ser Gln Ala Val Asn Gly Ser Gln Phe Leu
         505                 510                 515

 ccg ctg acc ggt ctg cag gtg cta gac ctg tcc cac aat aag ctg gac     2236
 Pro Leu Thr Gly Leu Gln Val Leu Asp Leu Ser His Asn Lys Leu Asp
     520                 525                 530

 ctc tac cac gag cac tca ttc acg gag cta ccg cga ctg gag gcc ctg     2284
 Leu Tyr His Glu His Ser Phe Thr Glu Leu Pro Arg Leu Glu Ala Leu
 535                 540                 545                 550

 gac ctc agc tac aac agc cag ccc ttt ggc atg cag ggc gtg ggc cac     2332
 Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly Met Gln Gly Val Gly His
                 555                 560                 565

 aac ttc agc ttc gtg gct cac ctg cgc acc ctg cgc cac ctc agc ctg     2380
 Asn Phe Ser Phe Val Ala His Leu Arg Thr Leu Arg His Leu Ser Leu
             570                 575                 580

 gcc cac aac aac atc cac agc caa gtg tcc cag cag ctc tgc agt acg     2428
 Ala His Asn Asn Ile His Ser Gln Val Ser Gln Gln Leu Cys Ser Thr
         585                 590                 595

 tcg ctg cgg gcc ctg gac ttc agc ggc aat gca ctg ggc cat atg tgg     2476
 Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn Ala Leu Gly His Met Trp
     600                 605                 610

 gcc gag gga gac ctc tat ctg cac ttc ttc caa ggc ctg agc ggt ttg     2524
 Ala Glu Gly Asp Leu Tyr Leu His Phe Phe Gln Gly Leu Ser Gly Leu
 615                 620                 625                 630

 atc tgg ctg gac ttg tcc cag aac cgc ctg cac acc ctc ctg ccc caa     2572
 Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu His Thr Leu Leu Pro Gln
                 635                 640                 645

 acc ctg cgc aac ctc ccc aag agc cta cag gtg ctg cgt ctc cgt gac     2620
 Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln Val Leu Arg Leu Arg Asp
             650                 655                 660

 aat tac ctg gcc ttc ttt aag tgg tgg agc ctc cac ttc ctg ccc aaa     2668
 Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser Leu His Phe Leu Pro Lys
         665                 670                 675

 ctg gaa gtc ctc gac ctg gca gga aac cag ctg aag gcc ctg acc aat     2716
 Leu Glu Val Leu Asp Leu Ala Gly Asn Gln Leu Lys Ala Leu Thr Asn
     680                 685                 690

 ggc agc ctg cct gct ggc acc cgg ctc cgg agg ctg gat gtc agc tgc     2764
 Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg Arg Leu Asp Val Ser Cys
 695                 700                 705                 710

 aac agc atc agc ttc gtg gcc ccc ggc ttc ttt tcc aag gcc aag gag     2812
 Asn Ser Ile Ser Phe Val Ala Pro Gly Phe Phe Ser Lys Ala Lys Glu
                 715                 720                 725

 ctg cga gag ctc aac ctt agc gcc aac gcc ctc aag aca gtg gac cac     2860
 Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala Leu Lys Thr Val Asp His
             730                 735                 740

 tcc tgg ttt ggg ccc ctg gcg agt gcc ctg caa ata cta gat gta agc     2908
 Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu Gln Ile Leu Asp Val Ser
         745                 750                 755

 gcc aac cct ctg cac tgc gcc tgt ggg gcg gcc ttt atg gac ttc ctg     2956
 Ala Asn Pro Leu His Cys Ala Cys Gly Ala Ala Phe Met Asp Phe Leu
     760                 765                 770

 ctg gag gtg cag gct gcc gtg ccc ggt ctg ccc agc cgg gtg aag tgt     3004
 Leu Glu Val Gln Ala Ala Val Pro Gly Leu Pro Ser Arg Val Lys Cys
 775                 780                 785                 790

 ggc agt ccg ggc cag ctc cag ggc ctc agc atc ttt gca cag gac ctg     3052
 Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser Ile Phe Ala Gln Asp Leu
                 795                 800                 805

 cgc ctc tgc ctg gat gag gcc ctc tcc tgg gac tgt ttc gcc ctc tcg     3100
 Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp Asp Cys Phe Ala Leu Ser
             810                 815                 820

 ctg ctg gct gtg gct ctg ggc ctg ggt gtg ccc atg ctg cat cac ctc     3148
 Leu Leu Ala Val Ala Leu Gly Leu Gly Val Pro Met Leu His His Leu
         825                 830                 835

 tgt ggc tgg gac ctc tgg tac tgc ttc cac ctg tgc ctg gcc tgg ctt     3196
 Cys Gly Trp Asp Leu Trp Tyr Cys Phe His Leu Cys Leu Ala Trp Leu
     840                 845                 850

 ccc tgg cgg ggg cgg caa agt ggg cga gat gag gat gcc ctg ccc tac     3244
 Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp Glu Asp Ala Leu Pro Tyr
 855                 860                 865                 870

 gat gcc ttc gtg gtc ttc gac aaa acg cag agc gca gtg gca gac tgg     3292
 Asp Ala Phe Val Val Phe Asp Lys Thr Gln Ser Ala Val Ala Asp Trp
                 875                 880                 885

 gtg tac aac gag ctt cgg ggg cag ctg gag gag tgc cgt ggg cgc tgg     3340
 Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu Glu Cys Arg Gly Arg Trp
             890                 895                 900

 gca ctc cgc ctg tgc ctg gag gaa cgc gac tgg ctg cct ggc aaa acc     3388
 Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly Lys Thr
         905                 910                 915

 ctc ttt gag aac ctg tgg gcc tcg gtc tat ggc agc cgc aag acg ctg     3436
 Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr Gly Ser Arg Lys Thr Leu
     920                 925                 930

 ttt gtg ctg gcc cac acg gac cgg gtc agt ggt ctc ttg cgc gcc agc     3484
 Phe Val Leu Ala His Thr Asp Arg Val Ser Gly Leu Leu Arg Ala Ser
 935                 940                 945                 950

 ttc ctg ctg gcc cag cag cgc ctg ctg gag gac cgc aag gac gtc gtg     3532
 Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu Asp Arg Lys Asp Val Val
                 955                 960                 965

 gtg ctg gtg atc ctg agc cct gac ggc cgc cgc tcc cgc tac gtg cgg     3580
 Val Leu Val Ile Leu Ser Pro Asp Gly Arg Arg Ser Arg Tyr Val Arg
             970                 975                 980

 ctg cgc cag cgc ctc tgc cgc cag agt gtc ctc ctc tgg ccc cac cag     3628
 Leu Arg Gln Arg Leu Cys Arg Gln Ser Val Leu Leu Trp Pro His Gln
         985                 990                 995

 ccc agt ggt cag cgc agc ttc tgg gcc cag ctg ggc atg gcc ctg acc     3676
 Pro Ser Gly Gln Arg Ser Phe Trp Ala Gln Leu Gly Met Ala Leu Thr
    1000                1005                1010

 agg gac aac cac cac ttc tat aac cgg aac ttc tgc cag gga ccc acg     3724
 Arg Asp Asn His His Phe Tyr Asn Arg Asn Phe Cys Gln Gly Pro Thr
1015                1020                1025                1030

 gcc gaa tag ccgtgag ccggaatcct gcacggtgcc acctccacac tcacctcacc     3780
 Ala Glu 






      <210> 257
      <211> 990
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(390)

      <400> 257
 caggagagaa caggagcagc cacagccagg agggagagcc ttccccaagc aaacaatcca     60

 gagcagctgt gcaaacaacg gtgcataaat gaggcctcct ggacc    atg aag cga     114
                                                      Met Lys Arg
                                                        1

 gtc ctg agc tgc gtc ccg gag ccc acg gtg gtc atg gct gcc aga gcg      162
 Val Leu Ser Cys Val Pro Glu Pro Thr Val Val Met Ala Ala Arg Ala
       5                  10                  15

 ctc tgc atg ctg ggg ctg gtc ctg gcc ttg ctg tcc tcc agc tct gct      210
 Leu Cys Met Leu Gly Leu Val Leu Ala Leu Leu Ser Ser Ser Ser Ala
  20                  25                  30                  35

 gag gag tac gtg ggc ctg tct gca aac cag tgt gcc gtg cca gcc aag      258
 Glu Glu Tyr Val Gly Leu Ser Ala Asn Gln Cys Ala Val Pro Ala Lys
                  40                  45                  50

 gac agg gtg gac tgc ggc tac ccc cat gtc acc ccc aag gag tgc aac      306
 Asp Arg Val Asp Cys Gly Tyr Pro His Val Thr Pro Lys Glu Cys Asn
              55                  60                  65

 aac cgg ggc tgc tgc ttt gac tcc agg atc cct gga gtg cct tgc tgt      354
 Asn Arg Gly Cys Cys Phe Asp Ser Arg Ile Pro Gly Val Pro Cys Cys
          70                  75                  80

 ttc aag ccc ctg cag gaa gca gaa tgc acc ttc tga ggca cctccagctg      404
 Phe Lys Pro Leu Gln Glu Ala Glu Cys Thr Phe 
      85                  90

 cccccggccg ggggatgcga ggctcggagc acccttgccc ggctgtgatt gctgccaggc    464

 actgttcatc tcagcttttc tgtccctttg cccccggcaa gcgcttctgc tgaaagttca    524

 tatctggagc ctgatgtctt aacgaataaa ggtcccatgc tccacccgag gacagttctt    584

 cgtgcctgag actttctgag gttgtgcttt atttctgctg cgtcgtggga gagggcggga    644

 gggtgtcagg ggagaggctg cccaggcctc aagggcagga aaagactccc taaggagctg    704

 cagtgcatgc aaggatattt tgaatccaga ctggcaccca cgtcacagga aagcctagga    764

 acactgtaag tgccgcttcc tcgggaaagc agaaaaaaaa catttcaggt agaagttttc    824

 aaaaatcaca agtctttctt ggtgaagaca gcaagccaat aaaactgtct tccaaagtgg    884

 tcctttattt cacaaccact ctcgctactg ttcaatactt gtactattcc tgggttttgt    944

 ttctttgtac agtaaacatt atgaacaaac aggcaaaaaa aaaaaa                   990




      <210> 258
      <211> 2620
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (541)..(1884)

      <400> 258
 agattagaat ttaatcgact catataggga tctggccctc gaggcaagaa ttcgctacga     60

 gagcctttca ggcccttcgg catacttcta gtgtaatcat tgtgacttca tcacaattga    120

 gttcttctgc atactctgag aacactccca tcctcagctt tcctagaaat ccagctcttt    180

 ctcctccctc agactcagga gtccagaccc cagccccttc tccctcacac acaggagtcc    240

 aggcctccag cccccgctcc ctcagaccca ggagtccagg ccccagatcc tcctccctca    300

 gtcctaggag tccgggcccc agcccctcct ccctcagact caggagttca ggccccagat    360

 cctcctccct cagacccagg aatacccccc agctcctctt ccctcagacc caggagtcca    420

 ggtccccagc ccctcctccc tcagacccag tggtccagag tcccagccct ctcagcttca    480

 agtcccttga gggtggggtt tgggggaagc ttgctgagtt ctgtgttcct ccaggcccag    540
                                                                 
 atg ggg gaa ccc cgg gct ggg gcc gcc ctg gac gat ggc agc ggc tgg      588
 Met Gly Glu Pro Arg Ala Gly Ala Ala Leu Asp Asp Gly Ser Gly Trp
   1               5                  10                  15

 acg ggc agt gag gaa ggc agt gag gag ggt acc ggc ggc agt gag ggg      636
 Thr Gly Ser Glu Glu Gly Ser Glu Glu Gly Thr Gly Gly Ser Glu Gly
              20                  25                  30

 gct ggg ggt gac ggg ggc ccg gat gca gag ggg gtg tgg agc cca gac      684
 Ala Gly Gly Asp Gly Gly Pro Asp Ala Glu Gly Val Trp Ser Pro Asp
          35                  40                  45

 att gag cag agc ttc cag gag gcc ctg gcc atc tat cca ccc tgc ggc      732
 Ile Glu Gln Ser Phe Gln Glu Ala Leu Ala Ile Tyr Pro Pro Cys Gly
      50                  55                  60

 cgc cgg aaa ata att ttg tct gat gaa ggc aag atg tat ggt cgg aat      780
 Arg Arg Lys Ile Ile Leu Ser Asp Glu Gly Lys Met Tyr Gly Arg Asn
  65                  70                  75                  80

 gaa ctg atc gcc cgc tac atc aag ctg aga acg ggg aag acc cga act      828
 Glu Leu Ile Ala Arg Tyr Ile Lys Leu Arg Thr Gly Lys Thr Arg Thr
                  85                  90                  95

 cga aaa cag gtt tct agt cac atc cag gtt ttg gcc cga agg aaa tca      876
 Arg Lys Gln Val Ser Ser His Ile Gln Val Leu Ala Arg Arg Lys Ser
             100                 105                 110

 agg gaa atc cag tcc aag ttg aag gac cag gtt tcc aag gac aag gct      924
 Arg Glu Ile Gln Ser Lys Leu Lys Asp Gln Val Ser Lys Asp Lys Ala
         115                 120                 125

 ttc cag aca atg gca acc atg tcc tct gcc cag ctc atc tcc gcg cct      972
 Phe Gln Thr Met Ala Thr Met Ser Ser Ala Gln Leu Ile Ser Ala Pro
     130                 135                 140

 tct ctg cag gcc aaa ctg ggt ccc act ggt cct cag gcc tct gag ctt     1020
 Ser Leu Gln Ala Lys Leu Gly Pro Thr Gly Pro Gln Ala Ser Glu Leu
 145                 150                 155                 160

 ttc cag ttt tgg tct gga gga tct ggg ccc ccc tgg aat gtt cca gat     1068
 Phe Gln Phe Trp Ser Gly Gly Ser Gly Pro Pro Trp Asn Val Pro Asp
                 165                 170                 175

 gtg aag cca ttc tca cag aca ccg ttc acc ttg tca ctg act ccc cca     1116
 Val Lys Pro Phe Ser Gln Thr Pro Phe Thr Leu Ser Leu Thr Pro Pro
             180                 185                 190

 tct act gac ctc cca ggg tac gag ccc ccc caa gcc ctc tca ccc ctg     1164
 Ser Thr Asp Leu Pro Gly Tyr Glu Pro Pro Gln Ala Leu Ser Pro Leu
         195                 200                 205

 ccc cca cct acc cca tcg ccc cca gcc tgg cag gct cgg ggc ctg ggc     1212
 Pro Pro Pro Thr Pro Ser Pro Pro Ala Trp Gln Ala Arg Gly Leu Gly
     210                 215                 220

 acc gcc cgg ttg cag ctg gta gag ttc tca gcc ttc gtg gaa ccg cca     1260
 Thr Ala Arg Leu Gln Leu Val Glu Phe Ser Ala Phe Val Glu Pro Pro
 225                 230                 235                 240

 gat gca gtt gat tct tac cag agg cac ctg ttc gtg cac atc agc cag     1308
 Asp Ala Val Asp Ser Tyr Gln Arg His Leu Phe Val His Ile Ser Gln
                 245                 250                 255

 cac tgc ccc agc ccc gga gcg ccg ccg ctc gag agt gtg gac gtc cgg     1356
 His Cys Pro Ser Pro Gly Ala Pro Pro Leu Glu Ser Val Asp Val Arg
             260                 265                 270

 cag atc tac gac aaa ttc cct gag aaa aag ggt ggc ctc cga gag cta     1404
 Gln Ile Tyr Asp Lys Phe Pro Glu Lys Lys Gly Gly Leu Arg Glu Leu
         275                 280                 285

 tat gat cgt ggc ccc ccc cat gcc ttc ttc ctg gtc aag ttc tgg gcg     1452
 Tyr Asp Arg Gly Pro Pro His Ala Phe Phe Leu Val Lys Phe Trp Ala
     290                 295                 300

 gac ctg aac tgg ggc cca agt ggt gag gag gca ggg gcc ggt ggc agc     1500
 Asp Leu Asn Trp Gly Pro Ser Gly Glu Glu Ala Gly Ala Gly Gly Ser
 305                 310                 315                 320

 atc agc agt ggt ggc ttc tac gga gtg agc agc cag tat gag agc ctg     1548
 Ile Ser Ser Gly Gly Phe Tyr Gly Val Ser Ser Gln Tyr Glu Ser Leu
                 325                 330                 335

 gaa cac atg acc ctc acc tgt tcc tcc aag gtc tgc tct ttt ggc aag     1596
 Glu His Met Thr Leu Thr Cys Ser Ser Lys Val Cys Ser Phe Gly Lys
             340                 345                 350

 cag gtg gtg gag aag gtg gag acg gaa cgg gcc cag ctg gag gac ggc     1644
 Gln Val Val Glu Lys Val Glu Thr Glu Arg Ala Gln Leu Glu Asp Gly
         355                 360                 365

 aga ttt gtg tac cgc ctg ctg cgc tcg ccc atg tgc gag tac ctg gtg     1692
 Arg Phe Val Tyr Arg Leu Leu Arg Ser Pro Met Cys Glu Tyr Leu Val
     370                 375                 380

 aat ttc ttg cac aag ttg cgg cag ctg cct gag cga tac atg atg aac     1740
 Asn Phe Leu His Lys Leu Arg Gln Leu Pro Glu Arg Tyr Met Met Asn
 385                 390                 395                 400

 agc gtc ctg gaa aac ttc acc atc ctc cag gtg gtg aca aac aga gac     1788
 Ser Val Leu Glu Asn Phe Thr Ile Leu Gln Val Val Thr Asn Arg Asp
                 405                 410                 415

 acc cag gaa ctg ctg ctc tgc acc gcc tat gtc ttc gag gtc tcc acc     1836
 Thr Gln Glu Leu Leu Leu Cys Thr Ala Tyr Val Phe Glu Val Ser Thr
             420                 425                 430

 agc gag cgt ggg gcc cag cat cac att tac cgc ctg gtc agg gac tga     1884
 Ser Glu Arg Gly Ala Gln His His Ile Tyr Arg Leu Val Arg Asp 
         435                 440                 445

 agggggaccc caaaactggc tcacccccca gaacaccctc ctcccaggga gggtcctcca   1944

 gctcacctca tgcttcttat ttggggagag ggctgtgatg taaaggggtt gacctcagag   2004

 gcctaagcaa ctggggccat cccccccatt agaggggccc ccaaaacttg gttggagagc   2064

 tgaacaggct gggactgagg aaaggataaa ccccgatatt gggacctcac agtgggtgtc   2124

 tgaaaggaca gatcactccg gagtatcagg gattgtgggg acaggagtga gacaaccccc   2184

 caggtacagc actggctttt cttttcagcc cctgacaggc cacccccact cctctgcatg   2244

 tcttggagag cgctagttac acattggctt gtccccttta ctttttccca gccacccctc   2304

 cccctgaaat ttctgcccct ctctaccacc ctcactccat gacctgtgag atcacaaagt   2364

 gaagatgaac cctttctgtg caggagcaga gccaggtggg ccctggacat tttttttttt   2424

 tttaatataa cgagatattt ataagtgggt gctagggtct tgactttatc tccgctgcac   2484

 aagcagtgtg ttgaactttc taatctcatc cctctcctaa gtgagccctg agctagacgg   2544

 tttccttcct cccctctcaa agtttgtttg tttgtgttct gacagaggat aaagctattt   2604

 taccaaaaaa aaaaaa                                                   2620




      <210> 259
      <211> 7028
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (361)..(2457)

      <400> 259
 ctcggaaccg gcccggaatt cccgggtcga cgatttcgta taaagggagc caggcagaga     60

 gagagaggga cttctgtaag gcggcacgac cacaccaaat aacagcagca gagggaggtg    120

 ggggagaggg aaataaaggg gagtcatgct taaaatgcta cagcggtgtg aaacagcaga    180

 gcaaagaagc gcccccagct tctgagagcc ctggcccgag tcccctcccc cgttagaaac    240

 agggctttgg gatggtcatg gagcactgcc agtaactcca accgcagcac gccggcctgc    300

 tcgcccatcc tccggaagcg gtctcgctcg ccaaccccgc agaaccagga cggagacacc    360
                                                                 
 atg gtg gag aag ggc tca gat cac tcc tcg gac aag tcc ccg tcc aca      408
 Met Val Glu Lys Gly Ser Asp His Ser Ser Asp Lys Ser Pro Ser Thr
   1               5                  10                  15

 ccg gag cag ggc gtg cag cgc agc tgc tcc tcc cag tcc ggc cgg agc      456
 Pro Glu Gln Gly Val Gln Arg Ser Cys Ser Ser Gln Ser Gly Arg Ser
              20                  25                  30

 ggc ggc aag aat tcc aag aaa agc cag agt tgg tat aat gtg tta agc      504
 Gly Gly Lys Asn Ser Lys Lys Ser Gln Ser Trp Tyr Asn Val Leu Ser
          35                  40                  45

 ccc acc tac aag cag aga aat gaa gac ttc aga aag ctc ttt aag cag      552
 Pro Thr Tyr Lys Gln Arg Asn Glu Asp Phe Arg Lys Leu Phe Lys Gln
      50                  55                  60

 ctt cca gac acg gag cgc ctc att gtt gat tac tca tgt gca ctc caa      600
 Leu Pro Asp Thr Glu Arg Leu Ile Val Asp Tyr Ser Cys Ala Leu Gln
  65                  70                  75                  80

 aga gac att ctc ctt cag ggc cga ctc tac ctc tct gaa aat tgg atc      648
 Arg Asp Ile Leu Leu Gln Gly Arg Leu Tyr Leu Ser Glu Asn Trp Ile
                  85                  90                  95

 tgc ttc tac agc aac atc ttc cgc tgg gaa act ctg ctg aca gtc cgt      696
 Cys Phe Tyr Ser Asn Ile Phe Arg Trp Glu Thr Leu Leu Thr Val Arg
             100                 105                 110

 ttg aaa gac atc tgt tcc atg act aaa gaa aaa aca gct cgc ctc att      744
 Leu Lys Asp Ile Cys Ser Met Thr Lys Glu Lys Thr Ala Arg Leu Ile
         115                 120                 125

 ccc aac gcc atc caa gtt tgc act gat tca gaa aag cac ttc ttc act      792
 Pro Asn Ala Ile Gln Val Cys Thr Asp Ser Glu Lys His Phe Phe Thr
     130                 135                 140

 tcg ttt ggg gcc cgg gat agg aca tat atg atg atg ttc cgg ctc tgg      840
 Ser Phe Gly Ala Arg Asp Arg Thr Tyr Met Met Met Phe Arg Leu Trp
 145                 150                 155                 160

 cag aat gct ctc ctt gaa aag cct ctg tgt ccc aag gag ctc tgg cac      888
 Gln Asn Ala Leu Leu Glu Lys Pro Leu Cys Pro Lys Glu Leu Trp His
                 165                 170                 175

 ttt gtt cac cag tgc tat ggg aac gaa ttg ggc ctg acc agt gat gac      936
 Phe Val His Gln Cys Tyr Gly Asn Glu Leu Gly Leu Thr Ser Asp Asp
             180                 185                 190

 gag gac tac gtg ccc cct gac gac gac ttc aac aca atg gga tac tgt      984
 Glu Asp Tyr Val Pro Pro Asp Asp Asp Phe Asn Thr Met Gly Tyr Cys
         195                 200                 205

 gaa gag atc cct gtg gaa gag aat gaa gtg aat gac agc tca tcc aag     1032
 Glu Glu Ile Pro Val Glu Glu Asn Glu Val Asn Asp Ser Ser Ser Lys
     210                 215                 220

 agc agc ata gag acc aag cca gat gcc agt cca cag ctg ccc aag aaa     1080
 Ser Ser Ile Glu Thr Lys Pro Asp Ala Ser Pro Gln Leu Pro Lys Lys
 225                 230                 235                 240

 tcc atc acc aac agc aca cta aca tcc aca ggg agc agt gag gcc ccc     1128
 Ser Ile Thr Asn Ser Thr Leu Thr Ser Thr Gly Ser Ser Glu Ala Pro
                 245                 250                 255

 gtc tcg ttt gat ggg ctg ccc ctg gag gaa gag gcg ctg gag gga gac     1176
 Val Ser Phe Asp Gly Leu Pro Leu Glu Glu Glu Ala Leu Glu Gly Asp
             260                 265                 270

 ggg tcc ctg gaa aag gag ctc gcc att gac aac atc atg ggg gag aag     1224
 Gly Ser Leu Glu Lys Glu Leu Ala Ile Asp Asn Ile Met Gly Glu Lys
         275                 280                 285

 att gag atg atc gct cct gtg aac tcc cct tca ctg gac ttc aat gac     1272
 Ile Glu Met Ile Ala Pro Val Asn Ser Pro Ser Leu Asp Phe Asn Asp
     290                 295                 300

 aat gag gac atc ccc act gag ctc agt gac tct tcc gac aca cac gat     1320
 Asn Glu Asp Ile Pro Thr Glu Leu Ser Asp Ser Ser Asp Thr His Asp
 305                 310                 315                 320

 gaa gga gag gtc cag gcc ttc tat gag gac ctg agt ggc cgg cag tac     1368
 Glu Gly Glu Val Gln Ala Phe Tyr Glu Asp Leu Ser Gly Arg Gln Tyr
                 325                 330                 335

 gtg aat gaa gtc ttc aac ttc agc gtg gac aag ctc tat gac ctc ctc     1416
 Val Asn Glu Val Phe Asn Phe Ser Val Asp Lys Leu Tyr Asp Leu Leu
             340                 345                 350

 ttc acc aac tcg ccc ttc cag cgg gat ttc atg gag cag cgg cgc ttc     1464
 Phe Thr Asn Ser Pro Phe Gln Arg Asp Phe Met Glu Gln Arg Arg Phe
         355                 360                 365

 tct gat atc atc ttc cat cca tgg aaa aag gag gag aat gga aac cag     1512
 Ser Asp Ile Ile Phe His Pro Trp Lys Lys Glu Glu Asn Gly Asn Gln
     370                 375                 380

 agc cga gtg att ctt tac acc atc acc ctt acc aac cct ctg gct ccc     1560
 Ser Arg Val Ile Leu Tyr Thr Ile Thr Leu Thr Asn Pro Leu Ala Pro
 385                 390                 395                 400

 aaa act gcc act gtc agg gag aca cag acc atg tac aag gcg agc cag     1608
 Lys Thr Ala Thr Val Arg Glu Thr Gln Thr Met Tyr Lys Ala Ser Gln
                 405                 410                 415

 gag agt gaa tgt tac gtg ata gat gcc gaa gtc ctc acc cac gac gtg     1656
 Glu Ser Glu Cys Tyr Val Ile Asp Ala Glu Val Leu Thr His Asp Val
             420                 425                 430

 ccc tac cat gac tac ttc tac aca atc aat cgc tac acg ctc acc cgt     1704
 Pro Tyr His Asp Tyr Phe Tyr Thr Ile Asn Arg Tyr Thr Leu Thr Arg
         435                 440                 445

 gtg gct cgg aac aag agc cga ctc agg gtc tcc aca gag ctg cgc tat     1752
 Val Ala Arg Asn Lys Ser Arg Leu Arg Val Ser Thr Glu Leu Arg Tyr
     450                 455                 460

 cga aaa cag ccc tgg ggg tta gtg aaa acg ttc atc gag aag aac ttc     1800
 Arg Lys Gln Pro Trp Gly Leu Val Lys Thr Phe Ile Glu Lys Asn Phe
 465                 470                 475                 480

 tgg agt ggg ctg gag gac tac ttc cgc cat tta gag agc gag ctg gcc     1848
 Trp Ser Gly Leu Glu Asp Tyr Phe Arg His Leu Glu Ser Glu Leu Ala
                 485                 490                 495

 aaa acg gag agc act tat ttg gct gag atg cac aga caa tct ccc aaa     1896
 Lys Thr Glu Ser Thr Tyr Leu Ala Glu Met His Arg Gln Ser Pro Lys
             500                 505                 510

 gag aag gcc agc aag act aca acg gtg cgg agg agg aag cgt ccc cat     1944
 Glu Lys Ala Ser Lys Thr Thr Thr Val Arg Arg Arg Lys Arg Pro His
         515                 520                 525

 gcc cac ctg cga gtc cct cac ctg gaa gag gtg atg agc ccg gtc acc     1992
 Ala His Leu Arg Val Pro His Leu Glu Glu Val Met Ser Pro Val Thr
     530                 535                 540

 acg ccc aca gat gag gat gtg ggc cac agg atc aaa cat gtg gca ggt     2040
 Thr Pro Thr Asp Glu Asp Val Gly His Arg Ile Lys His Val Ala Gly
 545                 550                 555                 560

 tcc aca cag acg cgg cat atc ccg gag gac acc ccc aac ggt ttc cac     2088
 Ser Thr Gln Thr Arg His Ile Pro Glu Asp Thr Pro Asn Gly Phe His
                 565                 570                 575

 ctg cag agc gtg tcc aag ctg ctg ctg gtt atc agc tgt gtg atc tgt     2136
 Leu Gln Ser Val Ser Lys Leu Leu Leu Val Ile Ser Cys Val Ile Cys
             580                 585                 590

 ttc agt ctg gtg ctg ctg gtc atc ctt aac atg atg ctc ttc tac aaa     2184
 Phe Ser Leu Val Leu Leu Val Ile Leu Asn Met Met Leu Phe Tyr Lys
         595                 600                 605

 ctc tgg atg ttg gaa tac acc acg cag acc ctc act gcc tgg cag ggt     2232
 Leu Trp Met Leu Glu Tyr Thr Thr Gln Thr Leu Thr Ala Trp Gln Gly
     610                 615                 620

 cta agg ctc caa gaa agg tta ccc cag tct cag aca gaa tgg gcc cag     2280
 Leu Arg Leu Gln Glu Arg Leu Pro Gln Ser Gln Thr Glu Trp Ala Gln
 625                 630                 635                 640

 ctc tta gag tcc caa caa aag tac cac gat act gag ctc caa aaa tgg     2328
 Leu Leu Glu Ser Gln Gln Lys Tyr His Asp Thr Glu Leu Gln Lys Trp
                 645                 650                 655

 agg gaa atc atc aaa tcc tca gtg atg ctc ctt gac cag atg aag gac     2376
 Arg Glu Ile Ile Lys Ser Ser Val Met Leu Leu Asp Gln Met Lys Asp
             660                 665                 670

 tcg ctc atc aac ctt cag aac ggc atc agg tcc cgc gac tac acg tcg     2424
 Ser Leu Ile Asn Leu Gln Asn Gly Ile Arg Ser Arg Asp Tyr Thr Ser
         675                 680                 685

 gaa agt gaa gaa aag agg aat cgc tat cat tga caaggcag gaacagggtg     2475
 Glu Ser Glu Glu Lys Arg Asn Arg Tyr His 
     690                 695

 gctgcaagag gcctgtgcaa tacatgtaca tagaccatat aaatatatat atataaatat   2535

 atatatatac agaatataaa tatatatatt atatacagat tttaaaaaag agataatgcc   2595

 tatgtaccag ggagaaggag cgggccctcc cgcgccctgt gctggccgga gcagcgtttt   2655

 cttatggtgg agcagctgag gagggcagga accgcctctc agcaccgacc tcccctgatc   2715

 tccctcctcc caccctctgt tccccacccc ttcccttgct ggccattctt ggcttttaga   2775

 agggaaatgt tgagccaaag ttatgcctgc gaagacccta aggtctcaaa aagaagtctt   2835

 aagacggcat tgcttaaggt gcttcattcc ctaatcccct tttgatttgt ttccaaaata   2895

 aaagagaatc ttttcttccc taccccaggc ttccccaggc attctcttgg gaacacagaa   2955

 gcatcaaggg agcccagtct aaactcctag ggttggccac ccacttgatc cggaccgtac   3015

 tgagtgtcag atggagagga tgcttggaaa gctaggaagg ctgcattgtg tggtggcagg   3075

 ctcccgagac tcgtgttctg aaggatactc tcctccatca cccctgcacc ttcctccgac   3135

 ctgtgtaggg tgtggaccca gtaagggctg ggaatttctt actttcccac ccgctttctc   3195

 tctggtcttc tcccaggctg gatctgggcg aagtgtcact ttttagtgcc taaagtccta   3255

 ttgtttctct gtgccctaag agcacattgt ttattagcca gggtggagcg ttttcgacct   3315

 tattaaacct cttttagtgc ttctaagcaa gtcaggtctg tggctctgag gccttcactt   3375

 agagctgtca gtgtgatttc caggatgagt cagggtgtgc tgggccctcc aggatttgag   3435

 agagggagag aaggcccttg ccacgtccgg ggtgcagggt ctacccacag aacactgtga   3495

 gtggtgagca ccaagatggg ttgccagcct catttgctct ttgaacgaac caacattagc   3555

 cagtggagac gactgtctga gacagtttgc acatagaaaa agcatctgag ccactggagg   3615

 gaaggatttg gcaaaggtgc atgtgtttgg gcaggaaaag agccaagtga aatctatgcc   3675

 ctacgggagc cattcccaat cctgagtttc tcagacttgg caatgggggt tctggcgggg   3735

 gttggagtac aaatcctgct ctggtctctg gccccacaga ggtgtaagat cattaagaag   3795

 tagaaggcac tagcttcaaa gagtgagaca ttcagggcct tttcagcatt ggcccactag   3855

 caccatgcat ttatctgaat tcacggggcc ctctgggcac attcatcatc cctcatacac   3915

 taactactgt ttcttcatgt aatgaccaaa agagtcccac cagctccagg cagagcttgt   3975

 ggagattcat gaaagagtca cagccagttt ggcatgcaga ggtcttcagt cttgcttatt   4035

 cttctcctgg gcttcttgac acaggggcag aagaaacccc agatgtccca gatgtcccag   4095

 aacatcagcc caaaagacag aagattttat cactcatcta ccccaaagat aaagttgtat   4155

 ttttctctta gaatggcctt taattccctg tggcaattac agtttttgac ttttccatgt   4215

 gagaataagg ccttggtatt tccctaaggg caggatcaga aaacaggaag gtccatgccc   4275

 aggtgatcct ccaagggagg agggtgagga ggctccaggg catgagctag agtggatatt   4335

 cctcccctag aagaggagat gggaggaaat gcagtttcat gtaatccctg tgaagagtgc   4395

 ctatgcccac agcccagtgg gtccttgttc agttcttgtc caggcctttg ggtgagggac   4455

 actggtaggg atcaaggctc atgggctctg agcaaagaag gaggcatggt gcagactgct   4515

 ggaaatctcc cccttggcac agccagaagc caaaactatt cccagaaagt tttgaatgca   4575

 aaacttgtag attcctgaat ttattccata cataattatt tccttaagtt atttaattat   4635

 taaaggtgcc acggtgggac ctttgggatg acttaaaaag ggttctttgt tgggagtcaa   4695

 gtgacagagc agacctggcc gcagggagtt gttctgcttc tgctttacct ctcaggacca   4755

 ttcccaggag gaaaatgtgg cagagagggc agtactgagt atgtcagaag agccctcctg   4815

 gttttttagc gatttgaacc cactagacaa tgtgtgcaca tagggaatgt cctttaagaa   4875

 tcatggatct cttgtaggct ctctgtgttc caataatttt ttgactatca taccaggaaa   4935

 aaaccaacaa ctctattcat tcccaaacaa aatctcttcc cccttagtca atagcttgcg   4995

 aaagagatct taactcaccc ttgcagataa gtcttggagt gaaacaaata aatagcattg   5055

 tattcctggc catttgcctg gctagttgct gtctacaagg gagcatcaaa acatcactac   5115

 ttcttatgta acttcttcca gccagtgctt ttattgttcg ttttagttta ctggggacac   5175

 acaggagtct ttctgtaatg acttatgtgg taaaatgttt gagagtttgc actcaatttt   5235

 aaagaatttg cagtttctaa caaggtgaag aacagctata ggatctaaag ttccattaca   5295

 gcttactgtg aaagaattga caagactggc ctcagacaag ctaatcatgg tgcgactctc   5355

 tcccttcctc atccacctct ttggggacaa gaggattaca tctcaggcca gcaagatcag   5415

 ctgcttgaag ctctgtgtaa gagcactgca ctgacggttt ggagacctga gcctgggtcc   5475

 tgacttttcc attgactaag ctctgtggcc ttgggcaagt cactccccct ctctgagctt   5535

 cagtatcctc ctgtcacagg agggagttgg gctagatcat ctttaaggta ggttctagct   5595

 ttgacatcat cttgggggtt aggccagagg ctgggaagac tgggtggact ttctcaattg   5655

 ctctgccagg agggaacaag cccagaggct gaagcttccc agtatttaga ggtgtggtag   5715

 ggcagtgtct gcattcccag gagacccagg gtgattaaaa tttattcttt aggtggctag   5775

 gagggctggg gaggcccagt ggaagagaga gagagagaga gagagagaga gagagagaga   5835

 gagagagaga tcgagcttga tgtattgctc agtattcact tagaagggtt tctttctctt   5895

 tggcctagtt tgtgaaggga tcttcctttg gactttctct aagttgggag aagaacattc   5955

 ttttcaatgg agctcatctt ctatctctag ggtctgttca gcctttcatc tatccatcct   6015

 tcctctttat tggtagaaga aacagtggag agtagccact tctggttcta gcacttctct   6075

 tttgttaaga tagggtttgg atttagtatg aagctttggc taaaaccctt gggtttgcct   6135

 tagaacactg acactaagaa cctggaatga catggggagg acaaagagag ctcaagagga   6195

 atgctttgtg agaagtggat tctctccgtg tccctgcccc ccacccaaac ttgaactata   6255

 cctattacat ttccaggcag tatccctaag atgagatcct ggagaaagga ctaggggaag   6315

 tatctttctg gatgcttgtg gtcccagaag ggtactttct gtgtcatacc atgccacttc   6375

 tttaagctct tcagggcagc caaagccagc ccttttctcc tactgccccc aggagaaata   6435

 gcactcttct cccttccccc agatggcagg gctctggcct ccctacacct cataccctgc   6495

 ctgcctcctc caggaggaat ctccggggcc ccttcctgac tctccccacc ttcgccactt   6555

 gtctctaggc tatgggacaa tcatcccatt caccacttga catccttgac atccttgact   6615

 ttcattcccc caacctccag caggttggcc ccaatcctct tcacctctgt gttttcttct   6675

 agaagatgca ttttgggtct gagaggagca ttttcctgga aggccatctt ttaaggcccc   6735

 tgcttgctgt catagtgcag agcagaaact tgcacactat ttagagagct cccttcccac   6795

 ctctctgccc agccttgtta cctcacttct gctctggcca tggctgtgaa gggcccagcc   6855

 agctccctgt tttgatgttc tgtgcaacag cctccggggt cttgtgactt gagatcctca   6915

 acaggcccct ggagccagga actggaagtc ttgggcagct gatgaagcag caccttgccc   6975

 ggccaggaag gagctgtagc ctgacgatct cccccaacat cgtgaaggct ata          7028




      <210> 260
      <211> 2865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (332)..(2818)

      <400> 260
 tttcgtcgcg ggcacagcag ccaggctgcc ggagagctga tctcggggat tcgggtgcgg     60

 agcccttggc ctggaggcga tatgggtggt ccgtggcccg gttcagtcgc ttgcagcagc    120

 ccggggaaca ggcctgtctg gccctgaggg agtccccttt ctgaagctgt ggtgcttgga    180

 cgacctgctc tctacattgc tgggcacctg taggtgtccc tcgagagctc agttttgagg    240

 ttcaagtcag tgtggccatg aaggggctgc ctattgggct gatgctgtga ccctggagtc    300

 tgcctctcct gccagtcccc ctgcccggaa c   atg tgg ctg cgg ctt ggc ccg     352
                                      Met Trp Leu Arg Leu Gly Pro
                                        1               5

 ccc tcg ctg tcc ctg agc ccc aag ccc acg gtt ggc agg agc ctg tgc      400
 Pro Ser Leu Ser Leu Ser Pro Lys Pro Thr Val Gly Arg Ser Leu Cys
          10                  15                  20

 ctc acc ctg tgg ttc ctc agt ttg gcg ctg agg gcc agt acc cag gcc      448
 Leu Thr Leu Trp Phe Leu Ser Leu Ala Leu Arg Ala Ser Thr Gln Ala
      25                  30                  35

 cca gca ccc aca gtc aac act cac ttt ggg aag cta agg ggt gcc cga      496
 Pro Ala Pro Thr Val Asn Thr His Phe Gly Lys Leu Arg Gly Ala Arg
  40                  45                  50                  55

 gta cca ctg ccc agt gag atc ctg ggg cct gtg gac caa tac ctg ggg      544
 Val Pro Leu Pro Ser Glu Ile Leu Gly Pro Val Asp Gln Tyr Leu Gly
                  60                  65                  70

 gtg ccc tac gca gct ccc ccg atc ggc gag aaa cgt ttc ctg ccc cct      592
 Val Pro Tyr Ala Ala Pro Pro Ile Gly Glu Lys Arg Phe Leu Pro Pro
              75                  80                  85

 gaa cca ccc cca tcc tgg tcg ggc att cgg aac gcc aca cac ttt ccc      640
 Glu Pro Pro Pro Ser Trp Ser Gly Ile Arg Asn Ala Thr His Phe Pro
          90                  95                 100

 cca gtg tgc ccc cag aac atc cac aca gct gtg ccc gaa gtc atg ctg      688
 Pro Val Cys Pro Gln Asn Ile His Thr Ala Val Pro Glu Val Met Leu
     105                 110                 115

 ccg gtc tgg ttc act gcc aac ttg gat atc gtc gct act tac atc cag      736
 Pro Val Trp Phe Thr Ala Asn Leu Asp Ile Val Ala Thr Tyr Ile Gln
 120                 125                 130                 135

 gag ccc aac gaa gac tgt ctc tac ctg aac gtc tat gtg ccg acg gag      784
 Glu Pro Asn Glu Asp Cys Leu Tyr Leu Asn Val Tyr Val Pro Thr Glu
                 140                 145                 150

 gat gga tcc ggc gct aag aaa cag ggc gag gac tta gcg gat aat gac      832
 Asp Gly Ser Gly Ala Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp
             155                 160                 165

 ggg gat gaa gat gaa gac atc cgg gac agt ggt gct aaa ccc gtc atg      880
 Gly Asp Glu Asp Glu Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met
         170                 175                 180

 gtc tac atc cac gga ggc tct tac atg gaa ggg aca ggc aac atg att      928
 Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile
     185                 190                 195

 gat ggc agc atc ctc gcc agt tat ggc aat gtc atc gtc atc acc ctc      976
 Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu
 200                 205                 210                 215

 aac tat cgg gtt gga gtg cta ggt ttc ctg agt act gga gat cag gct     1024
 Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala
                 220                 225                 230

 gcc aag ggc aac tat ggg ctc ctt gac cag atc cag gcc ctc cgc tgg     1072
 Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp
             235                 240                 245

 gtg agc gag aat att gcc ttc ttc ggg gga gac ccc cgc cgg atc act     1120
 Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr
         250                 255                 260

 gtc ttt ggc tcg ggc att ggt gca tcc tgc gtc agc ctc ctc acg ttg     1168
 Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu
     265                 270                 275

 tca cat cac tca gag gga ctt ttc cag aga gcc atc atc caa agt ggc     1216
 Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly
 280                 285                 290                 295

 tct gct ctg tcc agc tgg gct gtg aac tac caa cca gtg aag tac acc     1264
 Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr
                 300                 305                 310

 agc ctg ctg gca gac aaa gtg ggc tgt aat gtg ctg gac acc gtg gat     1312
 Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp
             315                 320                 325

 atg gtg gac tgt ctt cgg caa aag agt gcc aag gag ctg gta gag cag     1360
 Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln
         330                 335                 340

 gac atc cag cca gcc cgc tac cac gtg gcc ttt ggc cct gtg att gat     1408
 Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp
     345                 350                 355

 ggt gat gtc att cct gat gac cct gag atc ctc atg gag cag ggc gag     1456
 Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu
 360                 365                 370                 375

 ttc ctc aac tat gac atc atg cta ggt gtc aac cag ggc gag ggt ctc     1504
 Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu
                 380                 385                 390

 aag ttt gtg gaa ggg gtg gtg gac cct gag gat ggt gtc tct ggc act     1552
 Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr
             395                 400                 405

 gac ttt gac tat tcc gtc tcc aat ttt gtg gac aat ctg tat ggc tat     1600
 Asp Phe Asp Tyr Ser Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr
         410                 415                 420

 cct gag ggt aag gac acc ctg cga gag acc atc aag ttc atg tat aca     1648
 Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr
     425                 430                 435

 gac tgg gca gac cgt gac aac cct gag acc cgc cgt aaa aca ctg gtg     1696
 Asp Trp Ala Asp Arg Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val
 440                 445                 450                 455

 gca ctc ttc act gac cac cag tgg gtg gag ccc tca gtg gtg aca gcc     1744
 Ala Leu Phe Thr Asp His Gln Trp Val Glu Pro Ser Val Val Thr Ala
                 460                 465                 470

 gat ctg cat gcc cgc tac ggc tcg cct acc tac ttc tac gcc ttc tat     1792
 Asp Leu His Ala Arg Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr
             475                 480                 485

 cat cac tgc cag agc ctc atg aag cct gct tgg tca gat gca gct cat     1840
 His His Cys Gln Ser Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His
         490                 495                 500

 ggg gat gaa gta ccc tat gtt ttt ggg gtt cct atg gta ggc ccc act     1888
 Gly Asp Glu Val Pro Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr
     505                 510                 515

 gac ctt ttc ccc tgc aac ttc tcc aag aat gat gtt atg ctc agt gct     1936
 Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala
 520                 525                 530                 535

 gtc gtc atg acc tat tgg acc aac ttt gcc aag act ggg gat ccc aac     1984
 Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn
                 540                 545                 550

 aag ccg gtc ccc cag gac acc aag ttc att cac acc aag gcc aac cgc     2032
 Lys Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg
             555                 560                 565

 ttt gag gaa gtg gcc tgg tcc aaa tac aat ccc cga gac cag ctc tac     2080
 Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr
         570                 575                 580

 ctt cac atc ggg ctg aaa cca agg gtc cga gat cat tac cgg gcc act     2128
 Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr
     585                 590                 595

 aag gtg gcc ttt tgg aaa cat ctg gtg ccc cac cta tac aac ctg cat     2176
 Lys Val Ala Phe Trp Lys His Leu Val Pro His Leu Tyr Asn Leu His
 600                 605                 610                 615

 gac atg ttc cac tat acg tcc acc acc acc aaa gtg ccg cct ccg gat     2224
 Asp Met Phe His Tyr Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp
                 620                 625                 630

 acc acc cac agc tcc cac atc acc cgc agg ccc aat ggc aag acc tgg     2272
 Thr Thr His Ser Ser His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp
             635                 640                 645

 agc acc aag cgg cca gcc atc tca cct gcc tac agc aac gag aat gcc     2320
 Ser Thr Lys Arg Pro Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala
         650                 655                 660

 cag ggg tcc tgg aac ggg gac cag gat gca ggg cca ctc ctg gtg gag     2368
 Gln Gly Ser Trp Asn Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu
     665                 670                 675

 aac cct cgt gac tac tcc act gaa tta agt gtc acc atc gcc gtg ggg     2416
 Asn Pro Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly
 680                 685                 690                 695

 gcc tcc ctc ctg ttc ctt aac gtt ctg gcc ttc gct gcc ctc tac tac     2464
 Ala Ser Leu Leu Phe Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr
                 700                 705                 710

 cgt aag gac aaa cgg cgc cag gag ccc ctg cgg cag cct agc cct cag     2512
 Arg Lys Asp Lys Arg Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln
             715                 720                 725

 cgg gga gcc ggg gcc ccg gag ttg gga gct gct cca gag gag gag ctg     2560
 Arg Gly Ala Gly Ala Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu
         730                 735                 740

 gca gca tta caa ctg ggc ccc acc cac cac gag tgt gag gcc ggt ccc     2608
 Ala Ala Leu Gln Leu Gly Pro Thr His His Glu Cys Glu Ala Gly Pro
     745                 750                 755

 ccc cat gac acg ctg cgc ctc act gca ttg ccc gac tac acc ctg acc     2656
 Pro His Asp Thr Leu Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr
 760                 765                 770                 775

 ctg cgg cgc tcc ccg gat gac atc cca ctc atg acc ccc aac acc atc     2704
 Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile
                 780                 785                 790

 act atg atc ccc aac tcc ctg gta ggg ctg cag aca ttg cac ccc tat     2752
 Thr Met Ile Pro Asn Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr
             795                 800                 805

 aac acc ttt gcc gca ggg ttc aac agt acc ggg ctg ccc cac tca cac     2800
 Asn Thr Phe Ala Ala Gly Phe Asn Ser Thr Gly Leu Pro His Ser His
         810                 815                 820

 tcc act acc cgg gta tag ctccaa ctcagagcac agccaatctc caggctccct     2854
 Ser Thr Thr Arg Val 
     825

 ccctcccaga t                                                        2865




      <210> 261
      <211> 953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(387)

      <400> 261
 gaattcggca cgagctttat tgctcacaca aagcctgttt ggtggtctct tcac  atg      57
                                                              Met
                                                                1

 gat gcg cat gaa att tgg tgc ggt gac tcg gat cgg ggg acc tcc ctt      105
 Asp Ala His Glu Ile Trp Cys Gly Asp Ser Asp Arg Gly Thr Ser Leu
               5                  10                  15

 ggg aga tca atc ccc tgt cct cct gtt ctt tgc tcc gtg aga aag agc      153
 Gly Arg Ser Ile Pro Cys Pro Pro Val Leu Cys Ser Val Arg Lys Ser
          20                  25                  30

 cac cta cga cct cag gtc ctc aga cca acc agg cca aga aac atc tca      201
 His Leu Arg Pro Gln Val Leu Arg Pro Thr Arg Pro Arg Asn Ile Ser
      35                  40                  45

 cca att tca aat ccg gag ctt gct aca ctt gcc gga aat ctg gcc act      249
 Pro Ile Ser Asn Pro Glu Leu Ala Thr Leu Ala Gly Asn Leu Ala Thr
  50                  55                  60                  65

 ggg cca agg aat gcc cgc agc ccg gga ttc ctc cta agc cgt gtc cca      297
 Gly Pro Arg Asn Ala Arg Ser Pro Gly Phe Leu Leu Ser Arg Val Pro
                  70                  75                  80

 tct gtg tgg gac ccc act gaa aat cgg act gtt caa ctc acc tgg cag      345
 Ser Val Trp Asp Pro Thr Glu Asn Arg Thr Val Gln Leu Thr Trp Gln
              85                  90                  95

 cca ctc cca gag ccc ctg gaa ctc tgg ccc aag gct ctc tga ctgactc      394
 Pro Leu Pro Glu Pro Leu Glu Leu Trp Pro Lys Ala Leu 
         100                 105                 110

 cttcccagat cttctcggct tagcggctga agactgatgc tgcccgatcg cctcggaagc    454

 cccgtagacc atcacggacg ccgagcttcc ggtaactctc acagtggaag ggtaagtccg    514

 tccccttctt aatcaatacg gaggctaccc gctccacatt accttctttt caagggcctg    574

 tttcccttgc ctccataact gttgtgggta ttgacagcca ggcttctaaa cctcttaaaa    634

 ctccccaacg tctggtgcca acttggacaa cattctttta tacagtcctt tttagttatc    694

 tccacctgcc cacttccctt attaggtcga gacattttaa ccaaattatc tgcttccctg    754

 actattcttg gactacagcg gcatttcatt ggggcccttt ttcccaatcc aaagcctcct    814

 ttgggtcctc cttttgtatt cccccccctt aacccacaag tataagagac ctttactccc    874

 tccttggtga ctgatcacgc accccttacc ttttcattaa aattgaatca accctgaccc    934

 ctttccttca taaaaaaaa                                                 953




      <210> 262
      <211> 2401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(1117)

      <400> 262
 agtgctgcgt ccgtgcgccg cgggctgggg cggtctcagg tgtgccgaag ctctggtcag     60

 tgcc atg atc cgg cag gag cgc tcc aca tcc tac cag gag ctg agt gag     109
      Met Ile Arg Gln Glu Arg Ser Thr Ser Tyr Gln Glu Leu Ser Glu
        1               5                  10                  15

 gag ttg gtc cag gtg gtt gag aac tca gag ctg gca gac gag cag gac      157
 Glu Leu Val Gln Val Val Glu Asn Ser Glu Leu Ala Asp Glu Gln Asp
                  20                  25                  30

 aag gag acg gtc aga gtc caa ggt ccg ggt atc tta cca ggc ctg gac      205
 Lys Glu Thr Val Arg Val Gln Gly Pro Gly Ile Leu Pro Gly Leu Asp
              35                  40                  45

 agc gag tcc gcc tcc agc agc atc cgc ttc agc aag gcc tgc ctg aag      253
 Ser Glu Ser Ala Ser Ser Ser Ile Arg Phe Ser Lys Ala Cys Leu Lys
          50                  55                  60

 aac gtc ttc tcg gtc cta ctc atc ttc atc tac ctg ctg ctc atg gct      301
 Asn Val Phe Ser Val Leu Leu Ile Phe Ile Tyr Leu Leu Leu Met Ala
      65                  70                  75

 gtg gcc gtc ttc ctg gtc tac cgg acc atc aca gac ttt cgt gag aaa      349
 Val Ala Val Phe Leu Val Tyr Arg Thr Ile Thr Asp Phe Arg Glu Lys
  80                  85                  90                  95

 ctc aag cac cct gtc atg tct gtg tct tac aag gaa gtg gat cgc tat      397
 Leu Lys His Pro Val Met Ser Val Ser Tyr Lys Glu Val Asp Arg Tyr
                 100                 105                 110

 gat gcc cca ggt att gcc ttg tac ccc ggt cag gcc cag ttg ctc agc      445
 Asp Ala Pro Gly Ile Ala Leu Tyr Pro Gly Gln Ala Gln Leu Leu Ser
             115                 120                 125

 tgt aag cac cat tac gag gtc att cct cct ctg aca agc cct ggc cag      493
 Cys Lys His His Tyr Glu Val Ile Pro Pro Leu Thr Ser Pro Gly Gln
         130                 135                 140

 ccg ggt gac atg aat tgc acc acc cag agg atc aac tac acg gac ccc      541
 Pro Gly Asp Met Asn Cys Thr Thr Gln Arg Ile Asn Tyr Thr Asp Pro
     145                 150                 155

 ttc tcc aat cag act gtg aaa tct gcc ctg att gtc cag ggg ccc cgg      589
 Phe Ser Asn Gln Thr Val Lys Ser Ala Leu Ile Val Gln Gly Pro Arg
 160                 165                 170                 175

 gaa gtg aaa aag cgg gag ctg gtc ttc ctc cag ttc cgc ctg aac aag      637
 Glu Val Lys Lys Arg Glu Leu Val Phe Leu Gln Phe Arg Leu Asn Lys
                 180                 185                 190

 agt agt gag gac ttc agc gcc att gat tac ctc ctc ttc tct tct ttc      685
 Ser Ser Glu Asp Phe Ser Ala Ile Asp Tyr Leu Leu Phe Ser Ser Phe
             195                 200                 205

 cag gag ttc ctg caa agc cca aac agg gta ggc ttc atg cag gcc tgt      733
 Gln Glu Phe Leu Gln Ser Pro Asn Arg Val Gly Phe Met Gln Ala Cys
         210                 215                 220

 gag agt gcc tat tcc agc tgg aag ttc tct ggg ggc ttc cgc acc tgg      781
 Glu Ser Ala Tyr Ser Ser Trp Lys Phe Ser Gly Gly Phe Arg Thr Trp
     225                 230                 235

 gtc aag atg tca ctg gta aag acc aag gag gag gat ggg cgg gaa gca      829
 Val Lys Met Ser Leu Val Lys Thr Lys Glu Glu Asp Gly Arg Glu Ala
 240                 245                 250                 255

 gtg gag ttc cgg cag gag aca agt gtg gtt aac tac att gac cag agg      877
 Val Glu Phe Arg Gln Glu Thr Ser Val Val Asn Tyr Ile Asp Gln Arg
                 260                 265                 270

 cca gct gcc aaa aaa agt gct caa ttg ttt ttt gtg gtc ttt gaa tgg      925
 Pro Ala Ala Lys Lys Ser Ala Gln Leu Phe Phe Val Val Phe Glu Trp
             275                 280                 285

 aaa gat cct ttc atc cag aaa gtc caa gat ata gtc act gcc aat cct      973
 Lys Asp Pro Phe Ile Gln Lys Val Gln Asp Ile Val Thr Ala Asn Pro
         290                 295                 300

 tgg aac aca att gct ctt ctc tgt ggc gcc ttc ttg gca tta ttt aaa     1021
 Trp Asn Thr Ile Ala Leu Leu Cys Gly Ala Phe Leu Ala Leu Phe Lys
     305                 310                 315

 gca gca gag ttt gcc aaa ctg agt ata aaa tgg atg atc aaa att aga     1069
 Ala Ala Glu Phe Ala Lys Leu Ser Ile Lys Trp Met Ile Lys Ile Arg
 320                 325                 330                 335

 aag aga tac ctt aaa aga aga ggt cag gca acg agc cac ata agc tga     1117
 Lys Arg Tyr Leu Lys Arg Arg Gly Gln Ala Thr Ser His Ile Ser 
                 340                 345                 350

 agtcacctcg cgttgtttag agaactgtcc acatcaatgg gagctgtcat cacttccact   1177

 ttgtaaacgg agctatcaac aatcctgtac tcacttgaag aaatggggcc ttgctgggag   1237

 gaacagcatg taaaactgga acttctaacc ccgtcccaaa agaggcggtg tagagcctaa   1297

 tagaagagac taatggataa acctacaagt tatttaaata tttaaattat taataaactt   1357

 tttaaagagc tggccaatga cttttgaata gggtttgtag aagatgcctt tcttcctgtt   1417

 tggttcattg tattgtatta ggttaagctc tactagggta atgaaggctc tacttttcac   1477

 tttttaaaag tggacaaaag agtgtgattt tctttttcca aaaattcctg agtatcaaga   1537

 cgtgcaggtc atgctttgga gcctatgcac tgtacacaaa ggcaaaaccc tatgactttg   1597

 gcatcatctg ccattgatgt ccagcctctg acatgctctt tgatttgtta aatgttaaat   1657

 gagactttaa ggctactaga aactagtaat taagtttctt aatggactga gtagccacct   1717

 acttgtccgg ctagaatgtt tgttgatgta tgagtttaga ttaacactca aaagcactag   1777

 gacagatgta catagaaggt gcctactcat tgtattttga tgatttcatt aacaggtaaa   1837

 taaaagttaa tacaaaagga acgagtgtga caatatgaat atctgctcaa tcatcgggca   1897

 caattacttt catttggtga cttccaagga caaaaaggta gtatgagtct ggactcccaa   1957

 gatggatcta actctcaagg tatgttctaa ctgcttccag ggaagggttt gttaggcatg   2017

 gcaactgatg gcaggtgtcc agaaagagtg acctggtgtc cccgaggaag ctgggttaac   2077

 tctttactgt gtccacaaaa ctacccatca tatgaggaag gggtatacgc agtgtgaccc   2137

 tcaaaaagct tttagcctag cctttgacag aaatgagtat gcattaaaaa aaagtctatt   2197

 tttcacatta aggttctaaa aattgtttcc agagttttaa attatttatg tgcctgttgc   2257

 ttcaaagagg acttggtagc atttcctaaa ttttgtaatc tggcttccga taatccaaag   2317

 ggaataactc aaatgtatga ataggcattt taaatgggaa gaaactgttt tttggatgaa   2377

 tgattaaaag tgaactgtat aaag                                          2401




      <210> 263
      <211> 4911
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (466)..(1986)

      <400> 263
 actgtgctat gctaatttta accctcactc aagggaataa gcttgcggcc gcggtcccgc     60

 ccactgacgc gtccccgggg tgccgctata acccgccgct cgcagggctg ctccacagcc    120

 gcgcgacgcc gccgccttag aacgcctttc cagtactgct agcagcagcc cgaccacgcg    180

 ttaccgcacg ctcgcgcctt tcccttgaca cggcggacgc cggaggattg gggcggcaat    240

 ttgtcttttc cttttttatt aaaattattt ttcctgcctg ttgttggatt tggggaaatt    300

 ttttgtttgt tttttatgat ttgtatttga ctgagagaaa cccactgaag acgtctgcgt    360

 gagaatagag accaccgagg ccgactcgcg ggccgctgca cccaccgcca aggacaaaag    420

 gagcccagcg ctactagctg cacccgattc ctcccagtgc ttagc    atg aag aag     474
                                                      Met Lys Lys
                                                        1

 gcc gaa atg gga cga ttc agt att tcc ccg gat gaa gac agc agc agc      522
 Ala Glu Met Gly Arg Phe Ser Ile Ser Pro Asp Glu Asp Ser Ser Ser
       5                  10                  15

 tac agt tcc aac agc gac ttc aac tac tcc tac ccc acc aag caa gct      570
 Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr Lys Gln Ala
  20                  25                  30                  35

 gct ctg aaa agc cat tat gca gat gta gat cct gaa aac cag aac ttt      618
 Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn Gln Asn Phe
                  40                  45                  50

 tta ctt gaa tcg aat ttg ggg aag aag aag tat gaa aca gaa ttt cat      666
 Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr Glu Phe His
              55                  60                  65

 cca ggt act act tcc ttt gga atg tca gta ttt aat ctg agc aat gcg      714
 Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu Ser Asn Ala
          70                  75                  80

 att gtg ggc agt gga atc ctt ggg ctt tct tat gcc atg gct aat act      762
 Ile Val Gly Ser Gly Ile Leu Gly Leu Ser Tyr Ala Met Ala Asn Thr
      85                  90                  95

 gga att gct ctt ttt ata att ctc ttg aca ttt gtg tca ata ttt tcc      810
 Gly Ile Ala Leu Phe Ile Ile Leu Leu Thr Phe Val Ser Ile Phe Ser
 100                 105                 110                 115

 ctg tat tct gtt cat ctc ctt ttg aag act gcc aat gaa gga ggg tct      858
 Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu Gly Gly Ser
                 120                 125                 130

 tta tta tat gaa caa ttg gga tat aag gca ttt gga tta gtt gga aag      906
 Leu Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu Val Gly Lys
             135                 140                 145

 ctt gca gca tct gga tca att aca atg cag aac att gga gct atg tca      954
 Leu Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly Ala Met Ser
         150                 155                 160

 agc tac ctc ttc ata gtg aaa tat gag ttg cct ttg gtg atc cag gca     1002
 Ser Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val Ile Gln Ala
     165                 170                 175

 tta acg aac att gaa gat aaa act gga ttg tgg tat ctg aac ggg aac     1050
 Leu Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu Asn Gly Asn
 180                 185                 190                 195

 tat ttg gtt ctg ttg gtg tca ttg gtg gtc att ctt cct ttg tcg ctg     1098
 Tyr Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro Leu Ser Leu
                 200                 205                 210

 ttt aga aat tta gga tat ttg gga tat acc agt ggc ctt tcc ttg ttg     1146
 Phe Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu Ser Leu Leu
             215                 220                 225

 tgt atg gtg ttc ttt ctg att gtg gtc att tgc aag aaa ttt cag gtt     1194
 Cys Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys Phe Gln Val
         230                 235                 240

 ccg tgt cct gtg gaa gct gct ttg ata att aac gaa aca ata aac acc     1242
 Pro Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr Ile Asn Thr
     245                 250                 255

 acc tta aca cag cca aca gct ctt gta cct gct ttg tca cat aac gtg     1290
 Thr Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser His Asn Val
 260                 265                 270                 275

 act gaa aat gac tct tgc aga cct cac tat ttt att ttc aac tca cag     1338
 Thr Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe Asn Ser Gln
                 280                 285                 290

 act gtc tat gct gtg cca att ctg atc ttt tca ttt gtc tgt cat cct     1386
 Thr Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val Cys His Pro
             295                 300                 305

 gct gtt ctt ccc atc tat gaa gaa ctg aaa gac cgc agc cgt aga aga     1434
 Ala Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser Arg Arg Arg
         310                 315                 320

 atg atg aat gtg tcc aag att tca ttt ttt gct atg ttt ctc atg tat     1482
 Met Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe Leu Met Tyr
     325                 330                 335

 ctg ctt gcc gcc ctc ttt gga tac cta aca ttt tac gaa cat gtt gag     1530
 Leu Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu His Val Glu
 340                 345                 350                 355

 tca gaa ttg ctt cat acc tac tct tct atc ttg gga act gat att ctt     1578
 Ser Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr Asp Ile Leu
                 360                 365                 370

 ctt ctc att gtc cgt ctg gct gtg tta atg gct gtg acc ctg aca gta     1626
 Leu Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr Leu Thr Val
             375                 380                 385

 cca gta gtt att ttc cca atc cgg agt tct gta act cac ttg ttg tgt     1674
 Pro Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His Leu Leu Cys
         390                 395                 400

 gca tca aaa gat ttc agt tgg tgg cgt cat agt ctc att aca gtg tct     1722
 Ala Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile Thr Val Ser
     405                 410                 415

 atc ttg gca ttt acc aat tta ctt gtc atc ttt gtc cca act att agg     1770
 Ile Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro Thr Ile Arg
 420                 425                 430                 435

 gat atc ttt ggt ttt att ggt gca tct gca gct tct atg ttg att ttt     1818
 Asp Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met Leu Ile Phe
                 440                 445                 450

 att ctt cct tct gcc ttc tat atc aag ttg gtg aag aaa gaa cct atg     1866
 Ile Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys Glu Pro Met
             455                 460                 465

 aaa tct gta caa aag att ggg gct ttg ttc ttc ctg tta agt ggt gta     1914
 Lys Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu Ser Gly Val
         470                 475                 480

 ctg gtg atg acc gga agc atg gcc ttg att gtt ttg gat tgg gta cac     1962
 Leu Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp Trp Val His
     485                 490                 495

 aat gca cct gga ggt ggc cat taa ttggcaccac tcaaactcaa actcagtcca    2016
 Asn Ala Pro Gly Gly Gly His 
 500                 505

 tctgatgcca gtgttgagta aactcaacta ctatgaaatt tcacctaatg ttttcagttt   2076

 cacttccttt tgaagtgcag attcctcgct ggttcttctg agtgcagaat aagtgaactt   2136

 ttttgttttg ttttgttttt ttaagaaact tatctgtatg ttagaaatgg atatgaacaa   2196

 caaaaccacg agtctcgggt taagggaagt gacaatttta ttccattcca gagaatggac   2256

 aaactcttaa cttttatcaa gccacatgct tggctgtgtc attgtttaac ttggatattt   2316

 tatgatttta cttgaatgtg cctaatggaa ccatttgatg tgagaaacaa ttctttttaa   2376

 tttacagcaa aatattgaat aaccattgac aaaaacacta ttattttttg taccaaaaat   2436

 acttaaagac ctcagaagca ctcttttact tttaagaaat tgcttttttg aactttattc   2496

 agaagcagtt atcaataaat tccataaaat aatgtcattg gtatttaaaa atgaatatta   2556

 atataatgaa atggtttgcc tttttgtagg cataataagc caaatacttt tttacccaaa   2616

 ataattttta gagaaaatga tgtaatgaaa aattgtacca tgaattagga gcatagtttt   2676

 ttccatttaa acgtcaccat tacttaaaag atgattgatt attgctatac caaatcagat   2736

 gaactctgtt catcactttt cttctctgtc cccaaacaat ttggttcatt cagactgaaa   2796

 tgtttgtgtc ttcaacttat tagaatggaa gataatgcag atatttctgt gggaaataaa   2856

 ataactaatt ttgaggtacc aaatagtgca attgggtaaa acagggttta ttcagttgca   2916

 tctgtctcca gtgttgtatt gacagctctg ggtctttttt tgggccagcc cttttttgac   2976

 attgcttcca gcagtggaaa atgggcattt gatggcaata ggccaaaatt attgtgtcca   3036

 gagagtacac tttttcaaaa tgctcaccta ctggaagtgt gaattacttg acaatgtatg   3096

 gcttagttgt gttcatgttt tgtctacagt agaggtctaa tccacaggtt acacctatgt   3156

 ttgatatgat ataagttctc tttgcgtagg ccactgggtt tctcatgcag taagctttat   3216

 aaaaactcat ttgcactgga ctgtcatctc attcttgtac aacgtagaat tacttgttta   3276

 catccaacaa atggttagct agggaaaaca gtgcaaactg agtgttagta gtcattttgg   3336

 tccaactgca tgtcaaccct tccatttcaa tcccagttag aaatgaaaat aattactttg   3396

 aaacttggct ttaagagcac atttatcgta cgtcacagtg tatggtgaat atattattaa   3456

 ataatgtggt acttcgctca tcaggcataa tgtctaaaat ctaatataca taattccatt   3516

 aagtggttga aggaagcaaa taatggaatt gtcaattggt catctggctg taaggtttgc   3576

 ccttgaacta aaaatgttgt ttggggcaag ggccagaaat gtggagacat ggtttttgtt   3636

 acgcattctt gtattatatg tgactaaatt tacaaacaag atacatgtgt aattaaagac   3696

 ccttatggaa ctggaagacg tcttgtagtg ctacattggg tgaaaccgtt ggtccatttt   3756

 tgtctgtttc tatgaagata aaataattgg gggccatcta gaaatagaaa ggcagtggga   3816

 agacagattc tacggcactg ctttcattta attgggcttt aggcactcca ttcgaatgca   3876

 gaacctcacc tctagttgag accaagaatt ggcaaatttg catgagctcc tggaaagagt   3936

 tgctgacttt gtatctaaga cctgccaggg aataccaaga gttgtttcta cagacttttt   3996

 tttttttttt tgtatgggag aagatactgt ggcaaccagg aaggaatgga aaaaaaattc   4056

 tcttctctac agcaaattaa tgtgaggaag ctcctccaat cctctggcta tttaaggttc   4116

 aaaatcaagt gcctagggaa aattccaatg gatgattttc tgggagctat cttgtctacc   4176

 ttgaggttcc tgcacaatga attcccatta atgagcagtc ttcagtatta aaaccactgt   4236

 cttgtcacct cattttgcat tactgtcttc cgtggatgtt tcagttacaa ctgtaatgtt   4296

 atttatagaa caacattaat ccattaaagc taacctattt ttcaatattt atgataatct   4356

 atgtacatat attgtctgtc catatgtatt tgtaaatagg ttgtatataa tgtcaggttt   4416

 gggtcttggg ttcaagtgta tatattcctg taagtttctt aactgcattt tgatgaattc   4476

 acattatgta actataagaa ttgtcccaaa agtacctgta cagaaaattg aatattgaaa   4536

 aattgacaaa ttgtgtacaa acactaaaaa aaacttgttt aaattgtatt tgcaataaac   4596

 aacatcaaat tttttcatga aatcttggta caaattcaga tctcttattt aaaatttaaa   4656

 taaggaatac attttcaaaa tgcagtaatc aaaatgtgat ctagtgtaat gaaataaaat   4716

 gtgatctagt gtaatggaag acctttgaga acctgggtgt attaactttg tgtatatagt   4776

 gtaaatatcc ccactgtact gttagaggcc aacaattcta gtatggcttg ttggcaaaga   4836

 gtgctacacc gtttcaatga aacaatgtat gtttgtttta actgaactaa aataaataca   4896

 tgcttaatcc tgaaa                                                    4911




      <210> 264
      <211> 1587
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1245)

      <400> 264
  atg ggc ggg aac cac tcc cac aag ccc ccc gtg ttt gac gag aat gag      48
  Met Gly Gly Asn His Ser His Lys Pro Pro Val Phe Asp Glu Asn Glu
    1               5                  10                  15

 gaa gtc aac ttt gac cat ttt cag att ctg cgg gcc att ggt aaa ggg       96
 Glu Val Asn Phe Asp His Phe Gln Ile Leu Arg Ala Ile Gly Lys Gly
              20                  25                  30

 agt ttt gga aag gta tgc atc gtg cag aag cga gac act aag aaa atg      144
 Ser Phe Gly Lys Val Cys Ile Val Gln Lys Arg Asp Thr Lys Lys Met
          35                  40                  45

 tat gca atg aag tac atg aac aag cag aag tgc atc gag agg gat gag      192
 Tyr Ala Met Lys Tyr Met Asn Lys Gln Lys Cys Ile Glu Arg Asp Glu
      50                  55                  60

 gtt cgg aat gtt ttc cgg gag ctg cag atc atg caa ggg ctg gag cac      240
 Val Arg Asn Val Phe Arg Glu Leu Gln Ile Met Gln Gly Leu Glu His
  65                  70                  75                  80

 ccc ttc ctg gtc aat ctg tgg tac tcc ttc cag gat gag gag gac atg      288
 Pro Phe Leu Val Asn Leu Trp Tyr Ser Phe Gln Asp Glu Glu Asp Met
                  85                  90                  95

 ttc atg gtg gtg gac ctg ctc ctg gga ggc gac ctg cgc tac cat ctg      336
 Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp Leu Arg Tyr His Leu
             100                 105                 110

 cag cag aat gtg cat ttc aca gag ggg act gtg aaa ctc tac atc tgt      384
 Gln Gln Asn Val His Phe Thr Glu Gly Thr Val Lys Leu Tyr Ile Cys
         115                 120                 125

 gag ctg gca ctg gcc ctg gag tat ctt cag agg tac cac atc atc cac      432
 Glu Leu Ala Leu Ala Leu Glu Tyr Leu Gln Arg Tyr His Ile Ile His
     130                 135                 140

 aga gac atc aag cca gac aat atc ctg ctg gat gaa cac gga cat gtt      480
 Arg Asp Ile Lys Pro Asp Asn Ile Leu Leu Asp Glu His Gly His Val
 145                 150                 155                 160

 cac att aca gac ttc aac ata gcg acg gta gtg aaa gga gca gaa agg      528
 His Ile Thr Asp Phe Asn Ile Ala Thr Val Val Lys Gly Ala Glu Arg
                 165                 170                 175

 gct tcc tcc atg gct ggc acc aag ccc tac atg gct cca gaa gta ttc      576
 Ala Ser Ser Met Ala Gly Thr Lys Pro Tyr Met Ala Pro Glu Val Phe
             180                 185                 190

 cag gtg tac atg gac aga ggc ccc gga tac tcg tac cct gtc gac tgg      624
 Gln Val Tyr Met Asp Arg Gly Pro Gly Tyr Ser Tyr Pro Val Asp Trp
         195                 200                 205

 tgg tcc ctg ggc atc aca gcc tat gag ctg ctg cgg ggc tgg agg ccg      672
 Trp Ser Leu Gly Ile Thr Ala Tyr Glu Leu Leu Arg Gly Trp Arg Pro
     210                 215                 220

 tac gaa atc cac tcg gtc acg ccc atc gat gaa atc ctc aac atg ttc      720
 Tyr Glu Ile His Ser Val Thr Pro Ile Asp Glu Ile Leu Asn Met Phe
 225                 230                 235                 240

 aag gtg gag cgt gtc cac tac tcc tcc acg tgg tgc aag ggg atg gtg      768
 Lys Val Glu Arg Val His Tyr Ser Ser Thr Trp Cys Lys Gly Met Val
                 245                 250                 255

 gcc ctg ctg agg aag ctc ctg acc aag gat cct gag agc cgc gtg tcc      816
 Ala Leu Leu Arg Lys Leu Leu Thr Lys Asp Pro Glu Ser Arg Val Ser
             260                 265                 270

 agc ctt cat gac ata cag agc gtg ccc tac ttg gcc gac atg aac tgg      864
 Ser Leu His Asp Ile Gln Ser Val Pro Tyr Leu Ala Asp Met Asn Trp
         275                 280                 285

 gac gcg gtg ttc aag aag gca ctg atg ccc ggc ttt gtg ccc aat aaa      912
 Asp Ala Val Phe Lys Lys Ala Leu Met Pro Gly Phe Val Pro Asn Lys
     290                 295                 300

 ggg agg ttg aac tgc gat ccc aca ttt gag ctt gaa gag atg att cta      960
 Gly Arg Leu Asn Cys Asp Pro Thr Phe Glu Leu Glu Glu Met Ile Leu
 305                 310                 315                 320

 gaa tcc aag cca ctt cac aaa aag aag aag cga ttg gca aag aac aga     1008
 Glu Ser Lys Pro Leu His Lys Lys Lys Lys Arg Leu Ala Lys Asn Arg
                 325                 330                 335

 tcc agg gat ggc aca aag gac agc tgc ccg ctg aat gga cac ctg cag     1056
 Ser Arg Asp Gly Thr Lys Asp Ser Cys Pro Leu Asn Gly His Leu Gln
             340                 345                 350

 cac tgt ttg gag act gtc cgg gag gaa ttc atc ata ttc aac aga gag     1104
 His Cys Leu Glu Thr Val Arg Glu Glu Phe Ile Ile Phe Asn Arg Glu
         355                 360                 365

 aag ctc agg agg cag cag gga cag ggc agc cag ctc ttg gac acc gac     1152
 Lys Leu Arg Arg Gln Gln Gly Gln Gly Ser Gln Leu Leu Asp Thr Asp
     370                 375                 380

 agc cga ggg gga ggc cag gcc caa agc aag ctc cag gac ggg tgc aac     1200
 Ser Arg Gly Gly Gly Gln Ala Gln Ser Lys Leu Gln Asp Gly Cys Asn
 385                 390                 395                 400

 aac aac ctc ctc acc cac acc tgc acc cgt ggc tgc agc agc tga gcc     1248
 Asn Asn Leu Leu Thr His Thr Cys Thr Arg Gly Cys Ser Ser 
                 405                 410

 cacacttgtt gctgctcaac aggactgcac tcgtctctgc cctgcccacc cagagcccct   1308

 ctttgtgccc tgatggtccc tgtctcaccc ctgaaaacat cagatgcaga aaaagccctg   1368

 gacttggagc tgggaagcct gggttctggt cccatctcca tgactgattc acgtgtgacc   1428

 tcagacaagt cacgccctct ctgtgcctcc gttttctgca tctgccaaag gggttaaaca   1488

 cttctgcccc acttcaaatt acaagattat ggggagaacc caattaggta ggaaacatga   1548

 aaaacctttg atatttataa aatcattttt acgtgcaaa                          1587




      <210> 265
      <211> 566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(512)

      <400> 265
 cgtgaccggg ccggaattgc cgcgtcgacg atttcgtgtt ttgcgtggga ggcggtcccg     60

 ggatttcagg ggtctaccgg ctctcttatg gcgaatgcaa cccgaagaga gagtgagctg    120

 tatcttcaga gttgtctccg tctttccaag aacagaacaa a    atg aac aag gta     173
                                                  Met Asn Lys Val
                                                    1

 gat cag aag ttc cag ggg tca gta tca ttt aaa gat gtg act gtg ggc      221
 Asp Gln Lys Phe Gln Gly Ser Val Ser Phe Lys Asp Val Thr Val Gly
   5                  10                  15                  20

 ttc acc cag gag gag tgg cag cac ctg gac cct agt cag agg gct ctg      269
 Phe Thr Gln Glu Glu Trp Gln His Leu Asp Pro Ser Gln Arg Ala Leu
                  25                  30                  35

 tat aga gat gtg atg ctg gag aac tac agc aac ctt gtc tca gtg ggg      317
 Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly
              40                  45                  50

 tat tgt gct cac aaa cca gag gtg atc ttc agg ctg gaa caa gga gaa      365
 Tyr Cys Ala His Lys Pro Glu Val Ile Phe Arg Leu Glu Gln Gly Glu
          55                  60                  65

 gaa cca tgg aga ctg gag gaa gaa ttc cca agc cag agc ttt cca ggc      413
 Glu Pro Trp Arg Leu Glu Glu Glu Phe Pro Ser Gln Ser Phe Pro Gly
      70                  75                  80

 tcc tct tgg cta tgg tgg ttt ccc aga ctt tcc ttg ttt tgg atg acc      461
 Ser Ser Trp Leu Trp Trp Phe Pro Arg Leu Ser Leu Phe Trp Met Thr
  85                  90                  95                 100

 ttg aca gtt tgg agg aat cct ggt gag aag tct gga cag ctg atc acc      509
 Leu Thr Val Trp Arg Asn Pro Gly Glu Lys Ser Gly Gln Leu Ile Thr
                 105                 110                 115

 tga aaga gaggagccaa gaaaatcaat ctaaacattt gtgggaagtt gtattcatca      566
 






      <210> 266
      <211> 1464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(670)

      <400> 266
 tttttggata ctttgtgcct tatgttcact tgatctcaac atctgctgca atttgactgt     60

 tcag atg aaa cat gta aat gaa aga ttt caa gat gaa aaa aat aaa gag     109
      Met Lys His Val Asn Glu Arg Phe Gln Asp Glu Lys Asn Lys Glu
        1               5                  10                  15

 gtt gtt ctc atg tgc att ggc gtc act tca gga gtt gga cga ctg ctc      157
 Val Val Leu Met Cys Ile Gly Val Thr Ser Gly Val Gly Arg Leu Leu
                  20                  25                  30

 ttt ggc cgg att gca gat tat gtg cct ggt gtg aag aag gtt tat cta      205
 Phe Gly Arg Ile Ala Asp Tyr Val Pro Gly Val Lys Lys Val Tyr Leu
              35                  40                  45

 cag gta ctc tcc ttt ttc ttc att ggt ctg atg tcc atg atg att cct      253
 Gln Val Leu Ser Phe Phe Phe Ile Gly Leu Met Ser Met Met Ile Pro
          50                  55                  60

 ctg tgt agc atc ttt ggg gcc ctc att gct gtg tgc ctc atc atg ggt      301
 Leu Cys Ser Ile Phe Gly Ala Leu Ile Ala Val Cys Leu Ile Met Gly
      65                  70                  75

 ctc ttc gat gga tgc ttc att tcc att atg gct ccc ata gcc ttt gag      349
 Leu Phe Asp Gly Cys Phe Ile Ser Ile Met Ala Pro Ile Ala Phe Glu
  80                  85                  90                  95

 tta gtt ggt gcc cag gat gtc tcc caa gca att gga ttt ctg ctc gga      397
 Leu Val Gly Ala Gln Asp Val Ser Gln Ala Ile Gly Phe Leu Leu Gly
                 100                 105                 110

 ttc atg tct ata ccc atg act gtt ggc cca ccc att gca ggg tta ctt      445
 Phe Met Ser Ile Pro Met Thr Val Gly Pro Pro Ile Ala Gly Leu Leu
             115                 120                 125

 cgt gac aaa ctg ggc tcc tat gat gtg gca ttc tac ctc gct gga gtc      493
 Arg Asp Lys Leu Gly Ser Tyr Asp Val Ala Phe Tyr Leu Ala Gly Val
         130                 135                 140

 cct ccc ctt att gga ggt gct gtg ctt tgt ttt atc ccg tgg atc cat      541
 Pro Pro Leu Ile Gly Gly Ala Val Leu Cys Phe Ile Pro Trp Ile His
     145                 150                 155

 agt aag aag caa aga gag atc agt aaa acc act gga aaa gaa aag atg      589
 Ser Lys Lys Gln Arg Glu Ile Ser Lys Thr Thr Gly Lys Glu Lys Met
 160                 165                 170                 175

 gag aaa atg ttg gaa aac cag aac tct ctg ctg tca agt tca tct gga      637
 Glu Lys Met Leu Glu Asn Gln Asn Ser Leu Leu Ser Ser Ser Ser Gly
                 180                 185                 190

 atg ttc aag aaa gaa tct gac tct att att taa tatcttac atacctccac      688
 Met Phe Lys Lys Glu Ser Asp Ser Ile Ile 
             195                 200

 cagactggac ttgctttttg aattttaagc aagtttcctt tccttttata caaattgcaa    748

 atttcatatt tttttaatca catcctagga atagcacaat aattgggaaa tagaaccctt    808

 atcactagaa gaaccatttt ctgccactaa atatctctga tgtttccatg agtctgaggg    868

 cagagactct ggtatatgaa aacatgtctg aaagtcacat attgtgaaaa tttgaagcta    928

 tctcagtaaa aagcagcttt ggaaactgtg aatgatcttt agcttgtaca aatgtttaaa    988

 aatacctcag gctatactga aagggttgca gtttggttag gagtggaaat attttgtttg   1048

 ttaatgatgt cttcagttct ggtacctctg ttttactttc ttatgctctt tggaaacttt   1108

 ttgcaaaatt taagcctggg ttctagataa taccagatct acctaaacct caagtctatg   1168

 ttaaagttgc tttcctgctg ttaaataagc tatgatatta agatattctg acttgctcca   1228

 gtgtcaaggg accttctggg agcaggtgct aacatagtgt tcagaatcaa tatgtgagat   1288

 gaaaaggatc ccctccagga ggatcctgag ctgttcagaa atcatttaag tttacagcgt   1348

 tgttcccttt gcgtttgcag tgcgttttac tcaagtagcc agaaacaccc cacgtttctg   1408

 aatttgttta aactgtaaca ataaagtaaa atagaatgca tgaaagataa aaaaaa       1464




      <210> 267
      <211> 2349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (783)..(2186)

      <400> 267
 attttatatt tggcttatga aatgtattaa tttgcttctt ctggtcaaag ataaagtgga     60

 aggatgatga gatttttaaa aaattaatgt atcccttgct tctaattcta cctacaaagt    120

 ggaatagtgt gctagttact atatagttcc cagtgtatag cttttgactc ttttgaagtg    180

 gtaactagta gttttgtttt aaaattttgc tttcagcttt tatcctgaga ggggggctca    240

 ctgaacctct ctcctttcta aaatctgtgg aaattacttt tggtaactaa ggcactgcag    300

 tgatctcagg taagagagta aaaaatttgc ctttatttgt ttttaatgtt ttgggacgtt    360

 tcaggttttg gttgggtgga aacagagttg gggcaaacaa aaagaggctg gttaagagat    420

 tcagaggcaa aggttggttg gccatgctaa atttcaggtg cctgttgcac ctccatgtag    480

 caacagtaag tagacagata gcagattctt agggaagaag ttaagctaga gaagcagtgt    540

 ggtgtggtgt aaagaattct gggcattcaa ttaagaggtg tgggctctga gaggctaaca    600

 ctactactaa cttgctctgt gactttgacc aagtcatttg acctctctgg gccccatctt    660

 tattggaaaa tgtcaagtag atggtctcta ataaattttt gtccagttct aacattatgt    720

 gattctaaat gtatttatac tgaccttctt aacttgaact ctttgttttt tcagcattta    780

 gt   atg aga acc tat gtt tgc cat att tgt agt att gct ttt aca tct     827
      Met Arg Thr Tyr Val Cys His Ile Cys Ser Ile Ala Phe Thr Ser
        1               5                  10                  15

 tta gat atg ttc cgg tcc cac atg caa gga agt gaa cat caa att aaa      875
 Leu Asp Met Phe Arg Ser His Met Gln Gly Ser Glu His Gln Ile Lys
                  20                  25                  30

 gaa tcc att gtt atc aat cta gtg aag aat tca agg aag aca caa gac      923
 Glu Ser Ile Val Ile Asn Leu Val Lys Asn Ser Arg Lys Thr Gln Asp
              35                  40                  45

 tct tac caa aat gag tgt gca gat tac atc aat gtg cag aaa gcc aga      971
 Ser Tyr Gln Asn Glu Cys Ala Asp Tyr Ile Asn Val Gln Lys Ala Arg
          50                  55                  60

 gga cta gag gcc aag act tgt ttc aga aag atg gaa gag agt tct ttg     1019
 Gly Leu Glu Ala Lys Thr Cys Phe Arg Lys Met Glu Glu Ser Ser Leu
      65                  70                  75

 gaa acc cgt aga tac aga gaa gtg gtc gat tcc aga ccc aga cat aga     1067
 Glu Thr Arg Arg Tyr Arg Glu Val Val Asp Ser Arg Pro Arg His Arg
  80                  85                  90                  95

 atg ttt gaa caa aga ctc cca ttt gag act ttc cgg aca tac gca gca     1115
 Met Phe Glu Gln Arg Leu Pro Phe Glu Thr Phe Arg Thr Tyr Ala Ala
                 100                 105                 110

 cca tac aat att tca caa gca atg gaa aag cag tta cct cat tca aag     1163
 Pro Tyr Asn Ile Ser Gln Ala Met Glu Lys Gln Leu Pro His Ser Lys
             115                 120                 125

 aag aca tat gac tct ttc caa gat gaa ctt gaa gat tac atc aaa gta     1211
 Lys Thr Tyr Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val
         130                 135                 140

 cag aaa gcc aga gga cta gat cca aag act tgt ttc aga aag atg aga     1259
 Gln Lys Ala Arg Gly Leu Asp Pro Lys Thr Cys Phe Arg Lys Met Arg
     145                 150                 155

 gag aac tct gtg gat act cat ggg tac aga gaa atg gtt gat tct gga     1307
 Glu Asn Ser Val Asp Thr His Gly Tyr Arg Glu Met Val Asp Ser Gly
 160                 165                 170                 175

 ccc aga tca aga atg tgt gag caa aga ttt tca cat gag gct tcc cag     1355
 Pro Arg Ser Arg Met Cys Glu Gln Arg Phe Ser His Glu Ala Ser Gln
                 180                 185                 190

 acc tac caa cga cca tac cat att tca cca gtg gaa agc cag tta cct     1403
 Thr Tyr Gln Arg Pro Tyr His Ile Ser Pro Val Glu Ser Gln Leu Pro
             195                 200                 205

 cag tgg cta cca acc cat tca aag agg aca tat gat tct ttc caa gat     1451
 Gln Trp Leu Pro Thr His Ser Lys Arg Thr Tyr Asp Ser Phe Gln Asp
         210                 215                 220

 gaa ctt gaa gat tac ata aaa gtg cag aaa gcc aga gga cta gag cca     1499
 Glu Leu Glu Asp Tyr Ile Lys Val Gln Lys Ala Arg Gly Leu Glu Pro
     225                 230                 235

 aaa act tgt ttc aga aag ata gga gat agc tct gta gaa aca cac agg     1547
 Lys Thr Cys Phe Arg Lys Ile Gly Asp Ser Ser Val Glu Thr His Arg
 240                 245                 250                 255

 aac aga gaa atg gtt gat gtc aga ccc aga cat aga atg ttg gag caa     1595
 Asn Arg Glu Met Val Asp Val Arg Pro Arg His Arg Met Leu Glu Gln
                 260                 265                 270

 aag ctc cca tgt gag act ttc cag acc tat tca gga cca tat agt att     1643
 Lys Leu Pro Cys Glu Thr Phe Gln Thr Tyr Ser Gly Pro Tyr Ser Ile
             275                 280                 285

 tca caa gta gtg gaa aac cag tta cct cat tgc tta cca gct cat gat     1691
 Ser Gln Val Val Glu Asn Gln Leu Pro His Cys Leu Pro Ala His Asp
         290                 295                 300

 agc aaa cag aga cta gat tct att agc tac tgt caa ctc acc aga gac     1739
 Ser Lys Gln Arg Leu Asp Ser Ile Ser Tyr Cys Gln Leu Thr Arg Asp
     305                 310                 315

 tgt ttc cca gaa aaa cca gta ccc ttg agc ctt aat cag caa gaa aat     1787
 Cys Phe Pro Glu Lys Pro Val Pro Leu Ser Leu Asn Gln Gln Glu Asn
 320                 325                 330                 335

 aac tct ggc tca tac agt gta gaa tct gaa gtt tac aag cac ctc tct     1835
 Asn Ser Gly Ser Tyr Ser Val Glu Ser Glu Val Tyr Lys His Leu Ser
                 340                 345                 350

 tca gaa aac aat act gct gac cat caa gca ggt cat aaa cgg aaa cat     1883
 Ser Glu Asn Asn Thr Ala Asp His Gln Ala Gly His Lys Arg Lys His
             355                 360                 365

 cag aag aga aaa cga cac cta gaa gaa ggc aaa gaa agg cca gag aaa     1931
 Gln Lys Arg Lys Arg His Leu Glu Glu Gly Lys Glu Arg Pro Glu Lys
         370                 375                 380

 gag cag tcc aag cat aaa agg aaa aag agt tat gaa gat aca gat tta     1979
 Glu Gln Ser Lys His Lys Arg Lys Lys Ser Tyr Glu Asp Thr Asp Leu
     385                 390                 395

 gac aaa gac aag agc atc aga caa agg aaa aga gag gag gat aga gtc     2027
 Asp Lys Asp Lys Ser Ile Arg Gln Arg Lys Arg Glu Glu Asp Arg Val
 400                 405                 410                 415

 aag gtc agt tca gga aag ctt aag cat cga aaa aag aaa aaa agc cat     2075
 Lys Val Ser Ser Gly Lys Leu Lys His Arg Lys Lys Lys Lys Ser His
                 420                 425                 430

 gat gta ccc tcc gag aaa gaa gaa cgt aag cac agg aaa gag aaa aag     2123
 Asp Val Pro Ser Glu Lys Glu Glu Arg Lys His Arg Lys Glu Lys Lys
             435                 440                 445

 aaa tct gtt gaa gaa agg aca gaa gag gaa atg ctt tgg gat gag tct     2171
 Lys Ser Val Glu Glu Arg Thr Glu Glu Glu Met Leu Trp Asp Glu Ser
         450                 455                 460

 att ctt gga ttt tga atgtttagtt ttgtttaccc aaggttgaat tgaaaaaaaa     2226
 Ile Leu Gly Phe 
     465

 aaacagtcaa tatggattta gaaaaaggaa cacctgatga agaaaaggag aggtagatac   2286

 agtcagtgtc acttcaggac acttaggttt tttttgtata aaaatttaaa ttgaattaaa   2346

 aaa                                                                 2349




      <210> 268
      <211> 3336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(1804)

      <400> 268
 ggatgaaaac atccccagc atg gag atg tgt gac cag aga cac aat atc acc      52
                      Met Glu Met Cys Asp Gln Arg His Asn Ile Thr
                        1               5                  10

 atg tgc ccg ctt tgc gac aag acc tgc agc tac tgg aag atg agc tca      100
 Met Cys Pro Leu Cys Asp Lys Thr Cys Ser Tyr Trp Lys Met Ser Ser
              15                  20                  25

 gcc tgc gcc acg gcc cgc gcc agc cac ctc ttc gac aac ccc gcc acg      148
 Ala Cys Ala Thr Ala Arg Ala Ser His Leu Phe Asp Asn Pro Ala Thr
          30                  35                  40

 gtc ttc ttc tct gtc ttc atg gcc ctc tgg gct gcc acc ttc atg gag      196
 Val Phe Phe Ser Val Phe Met Ala Leu Trp Ala Ala Thr Phe Met Glu
      45                  50                  55

 cac tgg aag cgg aaa cag atg cga ctc aac tac cgc tgg gac ctc acg      244
 His Trp Lys Arg Lys Gln Met Arg Leu Asn Tyr Arg Trp Asp Leu Thr
  60                  65                  70                  75

 ggc ttt gaa gag gaa gag gag gct gtc aag gat cat cct aga gct gaa      292
 Gly Phe Glu Glu Glu Glu Glu Ala Val Lys Asp His Pro Arg Ala Glu
                  80                  85                  90

 tac gaa gcc aga gtc ttg gag aag tct ctg aag aaa gag tcc aga aac      340
 Tyr Glu Ala Arg Val Leu Glu Lys Ser Leu Lys Lys Glu Ser Arg Asn
              95                 100                 105

 aaa gag act gac aaa gtg aag ctg aca tgg aga gat cgg ttc cca gcc      388
 Lys Glu Thr Asp Lys Val Lys Leu Thr Trp Arg Asp Arg Phe Pro Ala
         110                 115                 120

 tac ctc act aac ttg gtc tcc atc atc ttc atg att gca gtg acg ttt      436
 Tyr Leu Thr Asn Leu Val Ser Ile Ile Phe Met Ile Ala Val Thr Phe
     125                 130                 135

 gcc atc gtc ctc ggc gtc atc atc tac agg atc tcc atg gcc gcc gcc      484
 Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met Ala Ala Ala
 140                 145                 150                 155

 ttg gcc atg aac tcc tcc ccc tcc gtg cgg tcc aac atc cgg gtc aca      532
 Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile Arg Val Thr
                 160                 165                 170

 gtc aca gcc acc gcg gtc atc atc aac cta gtg gtc atc atc ctc ctg      580
 Val Thr Ala Thr Ala Val Ile Ile Asn Leu Val Val Ile Ile Leu Leu
             175                 180                 185

 gac gag gtg tat ggc tgc ata gcc cga tgg ctc acc aag atc gag gtc      628
 Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Thr Lys Ile Glu Val
         190                 195                 200

 cca aag acg gag aaa agc ttt gag gag agg ctg atc ttc aag gct ttc      676
 Pro Lys Thr Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe Lys Ala Phe
     205                 210                 215

 ctg ctg aag ttt gtg aat tcc tac acc ccc atc ttt tac gtg gcg ttc      724
 Leu Leu Lys Phe Val Asn Ser Tyr Thr Pro Ile Phe Tyr Val Ala Phe
 220                 225                 230                 235

 ttc aaa ggc cgg ttt gtt gga cgc ccg ggc gac tac gtg tac att ttc      772
 Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val Tyr Ile Phe
                 240                 245                 250

 cgt tcc ttc cga atg gaa gag tgt gcg cca ggg ggc tgc ctg atg gag      820
 Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys Leu Met Glu
             255                 260                 265

 cta tgc atc cag ctc agc atc atc atg ctg ggg aaa cag ctg atc cag      868
 Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln Leu Ile Gln
         270                 275                 280

 aac aac ctg ttc gag atc ggc atc ccg aag atg aag aag ctc atc cgc      916
 Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys Leu Ile Arg
     285                 290                 295

 tac ctg aag ctg aag cag cag agc ccc cct gac cac gag gag tgt gtg      964
 Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu Glu Cys Val
 300                 305                 310                 315

 aag agg aaa cag cgg tac gag gtg gat tac aac ctg gag ccc ttc gcg     1012
 Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu Pro Phe Ala
                 320                 325                 330

 ggc ctc acc cca gag tac atg gaa atg atc atc cag ttt ggc ttc gtc     1060
 Gly Leu Thr Pro Glu Tyr Met Glu Met Ile Ile Gln Phe Gly Phe Val
             335                 340                 345

 acc ctg ttt gtc gcc tcc ttc ccc ctg gcc cca ctg ttt gcg ctg ctg     1108
 Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe Ala Leu Leu
         350                 355                 360

 aac aac atc atc gag atc cgc ctg gac gcc aaa aag ttt gtc act gag     1156
 Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe Val Thr Glu
     365                 370                 375

 ctc cga agg ccg gta gct gtc aga gcc aaa gac atc gga atc tgg tac     1204
 Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly Ile Trp Tyr
 380                 385                 390                 395

 aat atc ctc aga ggc att ggg aag ctt gct gtc atc atc aat gcc ttc     1252
 Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile Asn Ala Phe
                 400                 405                 410

 gtg atc tcc ttc acg tct gac ttc atc ccg cgc ctg gtg tac ctc tac     1300
 Val Ile Ser Phe Thr Ser Asp Phe Ile Pro Arg Leu Val Tyr Leu Tyr
             415                 420                 425

 atg tac agt aag aac ggg acc atg cac ggc ttc gtc aac cac acc ctc     1348
 Met Tyr Ser Lys Asn Gly Thr Met His Gly Phe Val Asn His Thr Leu
         430                 435                 440

 tcc tcc ttc aac gtc agt gac ttc cag aac ggc acg gcc ccc aat gac     1396
 Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Thr Ala Pro Asn Asp
     445                 450                 455

 ccc ctg gac ctg ggc tac gag gtg cag atc tgc agg tat aaa gac tac     1444
 Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr Lys Asp Tyr
 460                 465                 470                 475

 cga gag ccg ccg tgg tcg gaa aac aag tac gac atc tcc aag gac ttc     1492
 Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser Lys Asp Phe
                 480                 485                 490

 tgg gcc gtc ctg gca gcc cgg ctg gcg ttt gtc atc gtc ttc cag aac     1540
 Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val Phe Gln Asn
             495                 500                 505

 ctg gtc atg ttc atg agc gac ttt gtg gac tgg gtc atc ccg gac atc     1588
 Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile Pro Asp Ile
         510                 515                 520

 ccc aag gac atc agc cag cag atc cac aag gag aag gtg ctc atg gtg     1636
 Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val Leu Met Val
     525                 530                 535

 gag ctg ttc atg cgg gag gag caa gac aag cag cag ctg ctg gaa acc     1684
 Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu Leu Glu Thr
 540                 545                 550                 555

 tgg atg gag aag gag cgg cag aag gac gag ccg ccg tgc aac cac cac     1732
 Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys Asn His His
                 560                 565                 570

 aac acc aaa gcc tgc cca gac agc ctc ggc agc cca gcc ccc agc cat     1780
 Asn Thr Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala Pro Ser His
             575                 580                 585

 gcc tac cac ggg ggc gtc ctg tag ctatgccagc ggggctgggc aggccagccg    1834
 Ala Tyr His Gly Gly Val Leu 
         590

 ggcatcctga ccgatgggca ccctctccca gggcaggcgg cttcccgctc ccaccagggc   1894

 ccggtgggtc ctgggttttc tgcaaacatg gaggaccact ttctgatagg acattttcct   1954

 ttcttctttc tgctttcttt cccttgtttt tgcacaaagc cattatgcag ggaatatttt   2014

 ttaatctgta gtattcaaga tgaatcaaaa tgatggctgg taatacggca ataaggtagc   2074

 aaaggcaggt gctttgcaga aagaatgctt ggaaacttga gtctccctag aggtgaaaag   2134

 tgagcagagg cccctagaaa ccctcctctg aatcctccta attccttaag atagatgcaa   2194

 aatggtaagc cgaggcatcg cgcaaaagct ggtgcgatgc ttcagggaaa atggaaaacc   2254

 cacgcaagaa taatgattga ttccggttcc aaaaggtgtc acctacctgt ttcagaaaag   2314

 ttagactttc catcgccttt tccttccatc agttgagtgg ctgagagaga agtgcctcat   2374

 ccctgagcca cacagggggc gtgggagcat cccagttatc cctggaaagc tagaagggga   2434

 cagaggtgtc cctgattaag caggaaacag cacccttggc gtccccagca ggctccccac   2494

 tgtcagccac acacctgccc ccatcacacc aagccgacct cagagttgtt catcttcctt   2554

 atgggacaaa accggttgac cagaaaatgg gcagagagag atgacctcgg aagcatttcc   2614

 acagatggtg tcagggtttc aagaagtctt agggcttcca ggggtcccct ggaagcttta   2674

 gaatatttat gggttttttt ttcaaatatc aattatatgg tagattgagg attttttttc   2734

 tgtagctcaa aggtggaggg agtttattag ttaaccaaat atcgttgaga ggaatttaaa   2794

 atactgttac taccaaagat ttttattaat aaaggcttat attttggtaa cacttctcta   2854

 tatttttact cacaggaatg tcactgttgg acaattattt taaaagtgta taaaaccaag   2914

 tctcataaat gatatgagtg atctaaattt gcagcaatga tactaaacaa ctctctgaaa   2974

 tttctcaagc accaagagaa acatcatttt agcaaaggcc aggaggaaaa atagaaataa   3034

 atttgtcttg aagatctcat tgatgtgatg ttacattccc tttaatctgc caactgtggt   3094

 caaagttcat aggtgtcgta catttccatt atttgctaaa atcatgcaat ctgatgcttc   3154

 tcttttctct tgtacagtaa gtagtttgaa gtgggttttg tatataaata ctgtattaaa   3214

 aattaggcaa ttaccaaaaa tccttttatg gaaaccattt ttttaaaaag tgaatgtaca   3274

 caaatccaca gaggactgtg gctggacatt catctaaata aatttgaata tccgcccaaa   3334

 aa                                                                  3336




      <210> 269
      <211> 3391
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2522)..(3337)

      <400> 269
 tcagtagggg gagaatttct gccgctcagc cttcttgctc ccattagctg ctgccatctt     60

 ggcagtgtag gccgccaagc ccggcggcgg ccctggggaa gcaggtggta aagccaagaa    120

 gggcatgggc ttgaggccga tgaagttgga gagggagatg gcatagggtg tgcccagcag    180

 gccaggggga gctgtgggca gggccgtcag gggtggcgag aagggggcag gcaggtctgc    240

 gggggccgag ctgggcgtcc ccccagaggt agacttggcc gtctctagac aggcagtgat    300

 gaggtactgg gccagggcga tggagaccgg agagccagtg atggtgacat gccgctcccc    360

 agcgccctct gcttggttcc cgatcttgat atgtgcccct gacatctgcc ggatctcgct    420

 gatcttgctg ccctggcgcc cgatcacaca gccaatcaac ctccagccat cccatcccct    480

 gctcacatcg ttgggaacca agaactcctg tgagctggtc tgtgtgccgg gatccagtcc    540

 tggcaccacg ctgggtgtgg caaaggggac cgcatggctt gagagctgct ggagcttggt    600

 gacctcagct ggggtcacag ccccatactg accctggaca gagaagccct ccaggataac    660

 agcgcagatc tggcgcacac acaggatgat ggcatcaggc accccagata ccgtaacagc    720

 tcgctctgtg gagttgggga gcaggtcccc tgccacctgt acctgggcac ccgtagtctc    780

 tcggatctcc ttgatcttgg tgccagcctt cccaatcagt gagccacact gactggcagg    840

 gatgacaagg cgcagggtca ctggaggcct ggagacattt ccaccatttg caggagcagc    900

 acaaaggtcc tcatccagtt tgaaagcaat catggagact gcatggaaga cagctgctgt    960

 agacccggtg atggtggtga tgcgttcagg gcaggagccc tcggagatgg tgatccgggc   1020

 actgctctgc tcccggattc gctttacagt ctcgcccttc ttcccgatga tgctgcccac   1080

 ttccttcccg tgcatcagca tccgcagcgt gagggtgatg ctgagctctg gctcctcctc   1140

 cagtcccccg tccgagccgc tcattctgtc aggcgaggct ggggccacag cgactacaga   1200

 cacctctggg cagggttcat tcagcactgg gctgcagtgg gtggggcaca gcgtgtcagg   1260

 ggactggcag ttctgcacgt tggtttccaa tctctcttct atgtgctgga aatggcctcg   1320

 ctggggctgt cctgcggcgg cggcggcggc ggcacggcgg ctgggccgct cagtcccaca   1380

 ttgtccccgg gagaggcggc cgctcacaac tgcgagtgac atcagctgtt gcatgtgcat   1440

 gagccagagc tggagcccct gcaggaagtc cagcagccct gtatgccact cctctggttt   1500

 gtccaggtaa caggggtgcc ccgccccctt catgatcagc acccggtggt tgggcagctg   1560

 cttcaggtgc tcaaagctgg tctgacccat ggggtcctgg tctccatata caatcagagc   1620

 tggagtcttc acactggcat agttggcagc attgattttg tcagtgcaga tgggggccac   1680

 tggcacaaag cccgggagct gggagccagg ggccgtgagg aagggcaggg agtacatgcc   1740

 actcagtgat ggactgatca caaccggggg gcccagctcc aaggcatcca ccacagccgc   1800

 caggaagctg ccaggggcca gctccccaat aggggcaggg gctgctgctt ccttggagtg   1860

 ccccagacct ggcaggtcaa tggccacagc ccggtagcca gcctgggcca gcctgtgcag   1920

 tgtacccagg ttctgccagg tctcggagga gaagcgaata ccatgcagca gcagtacaga   1980

 gaagcgagcc tgcccactgc cgggcagggc ctctcggaag aagagggcct ggccctgcac   2040

 ctggatggtg ccctcgcgct gctccacgct tgctgccatg cctgctgctg ctgtgctggt   2100

 gaagggcctg tggttcaaaa ccacgatgat gaggggccac agaacacccc ccagtagctg   2160

 gaaccacagg cgcgcttcca caccggaaag cccattttct agaggcggaa accgaagcgc   2220

 ccagtgggaa aggcgacccg ccggggatgc ggggtgctca acgcgctgcc acctggggcc   2280

 caacgcgttg acctcgcggt caggttgctt ccgcggacta cggttctggc tcgctagctc   2340

 tggggagctg cgtggactcg cgcagacggg aagcaggcgc gtgctggcgg tgaccccctc   2400

 cacgcagacg actcggtaac tgggttgcag gcccgcggct gcggagtgcg caggcgcgcc   2460

 gagatggccg cgctcctggc cgcctagagc cggagcggcc cgcggagctg cggaggcagc   2520

 c    atg gtc ggg gcg ctg tgc ggc tgc tgg ttc cgc ctg ggc ggg gcc    2566
      Met Val Gly Ala Leu Cys Gly Cys Trp Phe Arg Leu Gly Gly Ala
        1               5                  10                  15

 cgc ccg ctc atc ccg ttg ggc ccg act gtg gta cag acc tcc atg agc     2614
 Arg Pro Leu Ile Pro Leu Gly Pro Thr Val Val Gln Thr Ser Met Ser
                  20                  25                  30

 cgg tcc cag gta gcc ctg ctg ggc ctg agt ctg ctg ctc atg ctc cta     2662
 Arg Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu
              35                  40                  45

 ctg tat gtg ggg ctg cca ggc ccc cct gag cag act tcc tgc ctc tgg     2710
 Leu Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp
          50                  55                  60

 gga gac ccc aat gtc aca gtc ctg gct ggt ctc acc cct ggc aac tcg     2758
 Gly Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser
      65                  70                  75

 ccc atc ttt tac cgc gag gtg ctc cca ctc aac cag gca cac agg gtg     2806
 Pro Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala His Arg Val
  80                  85                  90                  95

 gag gtg gtg ctg ctt cat gga aag gcc ttt aac tct cac acg tgg gag     2854
 Glu Val Val Leu Leu His Gly Lys Ala Phe Asn Ser His Thr Trp Glu
                 100                 105                 110

 cag ctg ggc aca ctg cag cta ctg tca cag agg ggc tac cgg gcc gtg     2902
 Gln Leu Gly Thr Leu Gln Leu Leu Ser Gln Arg Gly Tyr Arg Ala Val
             115                 120                 125

 gcc ctt gac ctt cca ggt ttt ggg aac tcg gca cct tca aag gag gca     2950
 Ala Leu Asp Leu Pro Gly Phe Gly Asn Ser Ala Pro Ser Lys Glu Ala
         130                 135                 140

 agc aca gag gca ggg cgg gca gcg ctg ctg gag cgg gcg ctg cgg gac     2998
 Ser Thr Glu Ala Gly Arg Ala Ala Leu Leu Glu Arg Ala Leu Arg Asp
     145                 150                 155

 ctg gag gta cag aat gcc gtg ttg gtg agc ccc tcg ctg agt ggc cac     3046
 Leu Glu Val Gln Asn Ala Val Leu Val Ser Pro Ser Leu Ser Gly His
 160                 165                 170                 175

 tat gcc ctg ccc ttc ctg atg cga ggc cac cac cag cta cat gga ttt     3094
 Tyr Ala Leu Pro Phe Leu Met Arg Gly His His Gln Leu His Gly Phe
                 180                 185                 190

 gtg ccc atc gca ccc acc tcc acc cag aac tac acc cag gag caa ttc     3142
 Val Pro Ile Ala Pro Thr Ser Thr Gln Asn Tyr Thr Gln Glu Gln Phe
             195                 200                 205

 tgg gct gtg aag act cca acc ctt atc ctg tat gga gag ctg gac cac     3190
 Trp Ala Val Lys Thr Pro Thr Leu Ile Leu Tyr Gly Glu Leu Asp His
         210                 215                 220

 atc ctg gct cga gag tca ctg cgg cag ctc cgc cac ctg ccc aac cac     3238
 Ile Leu Ala Arg Glu Ser Leu Arg Gln Leu Arg His Leu Pro Asn His
     225                 230                 235

 tct gtg gtg aag cta cgc aat gca ggc cat gcc tgt tac ctc cac aag     3286
 Ser Val Val Lys Leu Arg Asn Ala Gly His Ala Cys Tyr Leu His Lys
 240                 245                 250                 255

 ccg caa gac ttc cac ctt gtc ctg ctt gcc ttc ctt gac cat cta cct     3334
 Pro Gln Asp Phe His Leu Val Leu Leu Ala Phe Leu Asp His Leu Pro
                 260                 265                 270

 tga acta acccactccc agctcccagc ctggcatgag cttggacagt ctggaccgcc     3391
 






      <210> 270
      <211> 1273
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (272)..(985)

      <400> 270
 gagctgccgc gctgtccgcg ttatctcctc ccggtgagaa cgaaccgcag tgtccaccgg     60

 cgaggagcca gccctgtccc ggtcagagaa agacgacgag gatacctggg agcgggcggc    120

 ggccgggctg ggccgcgccg gtgcgggctg gcgactctgc tcctccgctt gctgctgtct    180

 ctgggaactg ggtgccagcg ctgaggggct tccagcggac agggaccccc ttccccggct    240

 cccctgccca ccctgccggg gagggcggaa g   atg ccg gtg aag aag aag aga     292
                                      Met Pro Val Lys Lys Lys Arg
                                        1               5

 aaa tcc cct ggg gtg gca gca gca gta gcg gaa gac gga ggc ctc aaa      340
 Lys Ser Pro Gly Val Ala Ala Ala Val Ala Glu Asp Gly Gly Leu Lys
          10                  15                  20

 aag tgt aaa atc tcc agc tat tgc aga tcc caa ccc cct gct aga cta      388
 Lys Cys Lys Ile Ser Ser Tyr Cys Arg Ser Gln Pro Pro Ala Arg Leu
      25                  30                  35

 ata agt gga gag gaa cat ttt tca agc aag aag tgc ctg gct tgg ttt      436
 Ile Ser Gly Glu Glu His Phe Ser Ser Lys Lys Cys Leu Ala Trp Phe
  40                  45                  50                  55

 tat gaa tat gca ggt cct gat gaa gtt gta ggg cca gaa gga atg gaa      484
 Tyr Glu Tyr Ala Gly Pro Asp Glu Val Val Gly Pro Glu Gly Met Glu
                  60                  65                  70

 aaa ttt tgt gaa gac att ggt gtt gaa cct gaa aat att att atg tta      532
 Lys Phe Cys Glu Asp Ile Gly Val Glu Pro Glu Asn Ile Ile Met Leu
              75                  80                  85

 gtt tta gcg tgg aaa ttg gag gct gaa agc atg gga ttt ttt acc aag      580
 Val Leu Ala Trp Lys Leu Glu Ala Glu Ser Met Gly Phe Phe Thr Lys
          90                  95                 100

 gaa gaa tgg tta aag gga atg act tca tta cag tgt gac tgc aca gaa      628
 Glu Glu Trp Leu Lys Gly Met Thr Ser Leu Gln Cys Asp Cys Thr Glu
     105                 110                 115

 aag tta caa aac aaa ttt gac ttt ttg cgc tca cag ttg aat gat att      676
 Lys Leu Gln Asn Lys Phe Asp Phe Leu Arg Ser Gln Leu Asn Asp Ile
 120                 125                 130                 135

 tcg tca ttt aag aat atc tac aga tat gcc ttt gat ttt gca agg gat      724
 Ser Ser Phe Lys Asn Ile Tyr Arg Tyr Ala Phe Asp Phe Ala Arg Asp
                 140                 145                 150

 aaa gat cag aga agc ctt gat att gat act gct aaa tct atg tta gct      772
 Lys Asp Gln Arg Ser Leu Asp Ile Asp Thr Ala Lys Ser Met Leu Ala
             155                 160                 165

 ctt ctg ctt ggg agg aca tgg cca ctg ttt tca gta ttt tac cag tac      820
 Leu Leu Leu Gly Arg Thr Trp Pro Leu Phe Ser Val Phe Tyr Gln Tyr
         170                 175                 180

 ctg gag caa tca aag tat cgt gtt atg aac aaa gat caa tgg tac aat      868
 Leu Glu Gln Ser Lys Tyr Arg Val Met Asn Lys Asp Gln Trp Tyr Asn
     185                 190                 195

 gta tta gaa ttc agc aga aca gtc cat gct gat ctt agt aac tat gat      916
 Val Leu Glu Phe Ser Arg Thr Val His Ala Asp Leu Ser Asn Tyr Asp
 200                 205                 210                 215

 gaa gat ggt gct tgg cct gtt ctt ctt gat gaa ttt gtt gag tgg caa      964
 Glu Asp Gly Ala Trp Pro Val Leu Leu Asp Glu Phe Val Glu Trp Gln
                 220                 225                 230

 aaa gtc cgt cag aca tca tag ca agaactatgt gaagaaaatg caaacctttc     1017
 Lys Val Arg Gln Thr Ser 
             235

 aattcccacg tgtatacaag ctaatgtgat gagggggaaa aaaatccaac gggtgcattt   1077

 tcattcatat gaaagacttc tcatagtact tttttttcct ttttttaaag gaggtttttc   1137

 ttgttacatg tgatgggcat tgagccacac ctcttcttag actgaatatt gaagtttttg   1197

 ttttgagtta tgtttataac atttatttca gaacaataaa gattcagatt tgtgacaaag   1257

 gccttaaagt gaaaaa                                                   1273




      <210> 271
      <211> 1706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (601)..(1272)

      <400> 271
 cacgagggcg gctcggctca gtcggtctgc gaggatccgg cccgccgccc cccgggggac     60

 ccgatggcct cggagggcct ggcgggggcg ctggcttccg tgctggctgg ccaggggtcc    120

 agcgtgcaca gctgcgactc ggcgccggcc ggggagccgc cggcgcccgt gcggctgcgg    180

 aagaacgtgt gctacgtggt gctggccgtg ttcctcagcg agcaggatga ggtgctactg    240

 atccaggagg ccaagaggga gtgccggggg tcgtggtacc tgcctgcggg gagaatggag    300

 ccaggggaga ccatcgtgga ggcgctgcag cgggaggtga aggaggaggc ggggctgcac    360

 tgtgagcccg agacactgct gtccgtggag gagcggggcc cctcctgggt ccgcttcgtg    420

 ttcctcgctc gccccacagg tatggcccac ctggaggcag tgtgaacagg gccagttgac    480

 acctttcccc cagctcctcg gtgaggtgag cccctctaca gccagtcctg ttatggctgg    540

 cacagcctgg catgggcaga ttccagcctt tgggctgggg gcctctctcc tgggtcaggg    600
                                                                 
 atg tct gtt gac tct gcc aga gct gca ctt ctc tcc aca cag acc ctc      648
 Met Ser Val Asp Ser Ala Arg Ala Ala Leu Leu Ser Thr Gln Thr Leu
   1               5                  10                  15

 cct gcc cca tcc ccc aca tct ccc cca ggt gga att ctc aag act tcc      696
 Pro Ala Pro Ser Pro Thr Ser Pro Pro Gly Gly Ile Leu Lys Thr Ser
              20                  25                  30

 aag gag gcc gat gcg gag tcc ctg cag gct gcc tgg tac cca cgg acc      744
 Lys Glu Ala Asp Ala Glu Ser Leu Gln Ala Ala Trp Tyr Pro Arg Thr
          35                  40                  45

 tcc ctg ccc act ccg ctg cga gcc cat gac atc ctg cac ctg gtt gaa      792
 Ser Leu Pro Thr Pro Leu Arg Ala His Asp Ile Leu His Leu Val Glu
      50                  55                  60

 cta gcc gcc cag tat cgc cag caa gcc agg cac cct ctc att ctg ccc      840
 Leu Ala Ala Gln Tyr Arg Gln Gln Ala Arg His Pro Leu Ile Leu Pro
  65                  70                  75                  80

 caa gag cta ccc tgt gat ctg gtc tgc cag cgg ctc gtg gct acc ttt      888
 Gln Glu Leu Pro Cys Asp Leu Val Cys Gln Arg Leu Val Ala Thr Phe
                  85                  90                  95

 acc agc gcc cag aca gtg tgg gtg tta gtg ggc aca gtg ggg atg cct      936
 Thr Ser Ala Gln Thr Val Trp Val Leu Val Gly Thr Val Gly Met Pro
             100                 105                 110

 cac ttg cct gtc act gcc tgt ggc ctc gac cct gtg gag cag agg ggt      984
 His Leu Pro Val Thr Ala Cys Gly Leu Asp Pro Val Glu Gln Arg Gly
         115                 120                 125

 ggc atg aag atg gcc gtc ctg cgg ctg ctg cag gag tgt ctg acc ctg     1032
 Gly Met Lys Met Ala Val Leu Arg Leu Leu Gln Glu Cys Leu Thr Leu
     130                 135                 140

 cac cac ttg gtg gtg gag atc aag ggg ttg ctt gga ctg cag cac ctg     1080
 His His Leu Val Val Glu Ile Lys Gly Leu Leu Gly Leu Gln His Leu
 145                 150                 155                 160

 ggc cga gat cac agt gat ggc atc tgt ttg aat gtg ctg gtg acc gtg     1128
 Gly Arg Asp His Ser Asp Gly Ile Cys Leu Asn Val Leu Val Thr Val
                 165                 170                 175

 gct ttt cgg agc cca ggg atc cag gat gaa ccc cca aaa gtt cgg ggt     1176
 Ala Phe Arg Ser Pro Gly Ile Gln Asp Glu Pro Pro Lys Val Arg Gly
             180                 185                 190

 gag aac ttc tct tgg tgg aag gtg atg gag gaa gac ctg caa agc cag     1224
 Glu Asn Phe Ser Trp Trp Lys Val Met Glu Glu Asp Leu Gln Ser Gln
         195                 200                 205

 ctc ctc cag cgg ctt cag gga tcc tct gtt gtc cca gtg aac aga tag     1272
 Leu Leu Gln Arg Leu Gln Gly Ser Ser Val Val Pro Val Asn Arg 
     210                 215                 220

 agaggtggag gaggtgacag ggagctaggc agccgtgctc cctccagtgc ggacttgtct   1332

 ccctctgagg gaggcaagag gctggcgatc agggatcttg ttgcattggg agcaggggcg   1392

 gctctcctgg tccccaggag agatgctttg aggagcattc ctctagattg cacaagggac   1452

 agtgccttta accaagcgag gagtccaaag ctcaggacct gactaccctg agggcacgct   1512

 gacgcctctc cccaggggga tggggagctt tctgcacccc cagtggcatc tcctcatcac   1572

 gttctgtgcc gtccttggga aaggcctgca ttctgatcct tccaggccct tcgagcatgg   1632

 aggggcactg gggaaggtcc cccgagggag gagcacgttg ctgagtaaag aggtgttact   1692

 ccccttgcaa aaaa                                                     1706




      <210> 272
      <211> 718
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(636)

      <400> 272
 gcc  atg gac aac tgt ttg gcg gcc gca gcg ctg aat ggg gtg gac cga      48
      Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg
        1               5                  10                  15

 cgt tcc ctg cag cgt tca gca agg ctg gct cta gaa gtg ctg gag agg       96
 Arg Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg
                  20                  25                  30

 gcc aag agg agg gcg gtg gac tgg cat gcc ctg gag cgt ccc aaa ggc      144
 Ala Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly
              35                  40                  45

 tgc atg ggg gtc ctt gcc cgg gag gcg ccc cac cta gag aaa cag ccg      192
 Cys Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro
          50                  55                  60

 gca gcc ggc ccg cag cgc gtt ctc ccg gga gag aga gaa gag aga ccc      240
 Ala Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro
      65                  70                  75

 cca acc ctt agt gct tcc ttc aga aca atg gct gaa ttc atg gac tat      288
 Pro Thr Leu Ser Ala Ser Phe Arg Thr Met Ala Glu Phe Met Asp Tyr
  80                  85                  90                  95

 act tca agt cag tgt ggg aaa tat tat tca tct gtg cca gag gaa gga      336
 Thr Ser Ser Gln Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly
                 100                 105                 110

 ggg gca acc cat gtc tat cgt tat cac aga ggc gag tcg aag ctg cac      384
 Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His
             115                 120                 125

 atg tgc ttg gac ata ggg aat ggt cag aga aaa gac aga aaa aag aca      432
 Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp Arg Lys Lys Thr
         130                 135                 140

 tcc ctt ggt cct gga ggc agc tat caa ata tca gag cat gct cca gag      480
 Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu His Ala Pro Glu
     145                 150                 155

 gca tcc cag cct gct gag aac atc tct aag gac ctc tac ata gaa gta      528
 Ala Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu Tyr Ile Glu Val
 160                 165                 170                 175

 tat cca ggg acc tat tct gtc act gtg ggc tca aat gac tta acc aag      576
 Tyr Pro Gly Thr Tyr Ser Val Thr Val Gly Ser Asn Asp Leu Thr Lys
                 180                 185                 190

 aag act cat gtg gta gca gtt gat tct gga caa agc gtg gac ctg gtc      624
 Lys Thr His Val Val Ala Val Asp Ser Gly Gln Ser Val Asp Leu Val
             195                 200                 205

 ttc cct gtg tga tgt tgaccatcac tgccatcaca tcaccttttt ttaagtagta      679
 Phe Pro Val 
         210

 agaataaagc cactgtatga ttctcttaaa aaaaaaaaa                           718




      <210> 273
      <211> 605
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(555)

      <400> 273
 gcc  atg gac aac tgt ttg gcg gcc gca gcg ctg aat ggg gtg gac cga      48
      Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg
        1               5                  10                  15

 cgt tcc ctg cag cgt tca gca agg ctg gct cta gaa gtg ctg gag agg       96
 Arg Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg
                  20                  25                  30

 gcc aag agg agg gcg gtg gac tgg cat gcc ctg gag cgt ccc aaa ggc      144
 Ala Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly
              35                  40                  45

 tgc atg ggg gtc ctt gcc cgg gag gcg ccc cac cta gag aaa cag ccg      192
 Cys Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro
          50                  55                  60

 gca gcc ggc ccg cag cgc gtt ctc ccg gga gag aaa tat tat tca tct      240
 Ala Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser
      65                  70                  75

 gtg cca gag gaa gga ggg gca acc cat gtc tat cgt tat cac aga ggc      288
 Val Pro Glu Glu Gly Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly
  80                  85                  90                  95

 gag tcg aag ctg cac atg tgc ttg gac ata ggg aat ggt cag aga aaa      336
 Glu Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys
                 100                 105                 110

 gac aga aaa aag aca tcc ctt ggt cct gga ggc agc tat caa ata tca      384
 Asp Arg Lys Lys Thr Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser
             115                 120                 125

 gag cat gct cca gag gca tcc cag cct gct gag aac atc tct aag gac      432
 Glu His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp
         130                 135                 140

 ctc tac ata gaa gta tat cca ggg acc tat tct gtc act gtg ggc tca      480
 Leu Tyr Ile Glu Val Tyr Pro Gly Thr Tyr Ser Val Thr Val Gly Ser
     145                 150                 155

 aat gac tta acc aag aag act cat gtg gta gca gtt gat tct gga caa      528
 Asn Asp Leu Thr Lys Lys Thr His Val Val Ala Val Asp Ser Gly Gln
 160                 165                 170                 175

 agc gtg gac ctg gtc ttc cct gtg tga tgttg accatcactg ccatcacatc      580
 Ser Val Asp Leu Val Phe Pro Val 
                 180

 accttttttt aagtagtaag aataa                                          605




      <210> 274
      <211> 556
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(474)

      <400> 274
 gcc  atg gac aac tgt ttg gcg gcc gca gcg ctg aat ggg gtg gac cga      48
      Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg
        1               5                  10                  15

 cgt tcc ctg cag cgt tca gca agg ctg gct cta gaa gtg ctg gag agg       96
 Arg Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg
                  20                  25                  30

 gcc aag agg agg gcg gtg gac tgg cat gcc ctg gag cgt ccc aaa ggc      144
 Ala Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly
              35                  40                  45

 tgc atg ggg gtc ctt gcc cgg gag gcg ccc cac cta gag aaa cag ccg      192
 Cys Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro
          50                  55                  60

 gca gcc ggc ccg cag cgc gtt ctc ccg gga gag aaa tat tat tca tct      240
 Ala Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser
      65                  70                  75

 gtg cca gag gaa gga ggg gca acc cat gtc tat cgt tat cac aga ggc      288
 Val Pro Glu Glu Gly Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly
  80                  85                  90                  95

 gag tcg aag ctg cac atg tgc ttg gac ata ggg aat ggt cag gct gag      336
 Glu Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Ala Glu
                 100                 105                 110

 aac atc tct aag gac ctc tac ata gaa gta tat cca ggg acc tat tct      384
 Asn Ile Ser Lys Asp Leu Tyr Ile Glu Val Tyr Pro Gly Thr Tyr Ser
             115                 120                 125

 gtc act gtg ggc tca aat gac tta acc aag aag act cat gtg gta gca      432
 Val Thr Val Gly Ser Asn Asp Leu Thr Lys Lys Thr His Val Val Ala
         130                 135                 140

 gtt gat tct gga caa agc gtg gac ctg gtc ttc cct gtg tga tgttgac      481
 Val Asp Ser Gly Gln Ser Val Asp Leu Val Phe Pro Val 
     145                 150                 155

 catcactgcc atcacatcac ctttttttaa gtagtaagaa taaagccact gtatgattct    541

 cttaaaaaaa aaaaa                                                     556




      <210> 275
      <211> 2264
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(1401)

      <400> 275
 gcacgagggg atgcggttcg gcggagcggc cgccacaggg acttgccgcc atcacccctg     60

 ctgccaccac cgcagcctcg ggctcccagg gcggacacgg ccaccgcctc agcgggagag    120

 gagtctccac caggactgac cgctgccgcc cagcacgtcc aggtaaggta ctcaactgtg    180

 tggggtacta cataaatcct gaaagactac aataaagtgg tg   atg tct cgg gaa     234
                                                  Met Ser Arg Glu
                                                    1

 ccc acc cca cct cta cct gga gat atg tct act ggt ccc ata gca gaa      282
 Pro Thr Pro Pro Leu Pro Gly Asp Met Ser Thr Gly Pro Ile Ala Glu
   5                  10                  15                  20

 agc tgg tgt tac aca cag gtt aaa gta gta aaa ttt tcc tat atg tgg      330
 Ser Trp Cys Tyr Thr Gln Val Lys Val Val Lys Phe Ser Tyr Met Trp
                  25                  30                  35

 acc att aat aac ttc agt ttt tgt cga gag gaa atg ggt gaa gtg tta      378
 Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met Gly Glu Val Leu
              40                  45                  50

 aaa agt tca aca ttt tca tct ggc cca agt gac aaa atg aaa tgg tgc      426
 Lys Ser Ser Thr Phe Ser Ser Gly Pro Ser Asp Lys Met Lys Trp Cys
          55                  60                  65

 ctg agg gta aac cca aag gga tta gat gat gaa agt aaa gac tac ttg      474
 Leu Arg Val Asn Pro Lys Gly Leu Asp Asp Glu Ser Lys Asp Tyr Leu
      70                  75                  80

 tcc tta tat ttg ctt tta gtc agc tgc ccc aaa agt gaa gtt cga gca      522
 Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser Glu Val Arg Ala
  85                  90                  95                 100

 aaa ttc aaa ttt tcc ctt ctg aat gct aaa agg gaa gaa aca aaa gca      570
 Lys Phe Lys Phe Ser Leu Leu Asn Ala Lys Arg Glu Glu Thr Lys Ala
                 105                 110                 115

 atg gaa agc caa aga gca tat cga ttt gtg caa ggg aag gac tgg ggt      618
 Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly Lys Asp Trp Gly
             120                 125                 130

 ttt aaa aaa ttc att aga agg gac ttt ttg ctt gat gaa gct aat ggt      666
 Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp Glu Ala Asn Gly
         135                 140                 145

 ctt tta cca gat gac aag ctt aca tta ttt tgt gag gtg agt gtg gtc      714
 Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu Val Ser Val Val
     150                 155                 160

 caa gat tca gta aac ata tca gga cat act aat aca aat act ttg aag      762
 Gln Asp Ser Val Asn Ile Ser Gly His Thr Asn Thr Asn Thr Leu Lys
 165                 170                 175                 180

 gtg cct gag tgt cgt cta gca gaa gat tta ggt aat ctc tgg gaa aac      810
 Val Pro Glu Cys Arg Leu Ala Glu Asp Leu Gly Asn Leu Trp Glu Asn
                 185                 190                 195

 aca aga ttt aca gac tgc agt ttt ttc gtg aga gga caa gaa ttt aaa      858
 Thr Arg Phe Thr Asp Cys Ser Phe Phe Val Arg Gly Gln Glu Phe Lys
             200                 205                 210

 gct cat aaa tct gtg ctt gca gct cga tct cca gtt ttt aac gcc atg      906
 Ala His Lys Ser Val Leu Ala Ala Arg Ser Pro Val Phe Asn Ala Met
         215                 220                 225

 ttt gaa cat gaa atg gaa gaa agc aaa aag aat cga gtg gaa ata aat      954
 Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg Val Glu Ile Asn
     230                 235                 240

 gat tta gac cct gaa gtt ttt aaa gaa atg atg aga ttc att tac aca     1002
 Asp Leu Asp Pro Glu Val Phe Lys Glu Met Met Arg Phe Ile Tyr Thr
 245                 250                 255                 260

 ggg aga gca cca aac ctt gac aaa atg gct gac aac ttg ttg gca gct     1050
 Gly Arg Ala Pro Asn Leu Asp Lys Met Ala Asp Asn Leu Leu Ala Ala
                 265                 270                 275

 gca gac aaa tat gca ctg gaa cgg ctg aag gtc atg tgc gaa gaa gct     1098
 Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met Cys Glu Glu Ala
             280                 285                 290

 ttg tgt agt aac ctc tca gta gag aat gtt gca gat acc ctt gtc ctt     1146
 Leu Cys Ser Asn Leu Ser Val Glu Asn Val Ala Asp Thr Leu Val Leu
         295                 300                 305

 gca gat ttg cac agt gca gaa cag ttg aaa gca caa gcc ata gac ttt     1194
 Ala Asp Leu His Ser Ala Glu Gln Leu Lys Ala Gln Ala Ile Asp Phe
     310                 315                 320

 att aat agg tgc agt gta ctt cga caa ctt ggg tgt aaa gat ggg aaa     1242
 Ile Asn Arg Cys Ser Val Leu Arg Gln Leu Gly Cys Lys Asp Gly Lys
 325                 330                 335                 340

 aac tgg aac agc aac caa gca acc gac ata atg gaa aca tca ggg tgg     1290
 Asn Trp Asn Ser Asn Gln Ala Thr Asp Ile Met Glu Thr Ser Gly Trp
                 345                 350                 355

 aag tcc atg att cag tct cac cct cat tta gta gca gaa gcc ttt cga     1338
 Lys Ser Met Ile Gln Ser His Pro His Leu Val Ala Glu Ala Phe Arg
             360                 365                 370

 gca cta gca tct gca cag tgt cca cag ttt ggc att cca cgc aaa cgg     1386
 Ala Leu Ala Ser Ala Gln Cys Pro Gln Phe Gly Ile Pro Arg Lys Arg
         375                 380                 385

 cta aaa cag tcc tga aatcttccat gaacagttga aaaatggaat tgactttcac     1441
 Leu Lys Gln Ser 
     390

 tcctccaggt ccagaaggat tctaatacac aaaccataag caagagttgt ttctgttatt   1501

 ttgtccacag aacagaagct gaaaaagcat attgcttgca tttcaggtgg ataatttatg   1561

 gtttattctt cagctttaaa ttagactgat taattcactt caaggcctta aattatcttc   1621

 aatgacttct cttgttcata taatacttta attttttttt tttttgcctt gtcattttga   1681

 ccaaggctat gcaggattgc actagctcca taatgcagta atattgataa ctgaagatac   1741

 taagtttcaa aaggatcttc cattattttg caaaaagaaa aatgaatttt atagggtttg   1801

 tcctatgcta tctcaaagtt taagttctct ttaaaagcac ttgtattgga gattaccagt   1861

 aatatctcca atctaagttc tataaatatg ggagaaccct cttaccttca aggtaagtta   1921

 tggcaataca ctgcttcaat tctaatttat ttttcatttc agggggcaaa tatgcaatga   1981

 gttggcctag atttttagtg acatttatga tgtttgtctt gtatgttaac tgtccaacaa   2041

 actgggggtt tattctaagt ttacaattat tgagatctga ttgaggttaa gatttcatga   2101

 acaaagcatg gattgcgcgg aagtaattct tttttaattg atactgaccc acctttatac   2161

 gaaaaattct gtacatgtta aaagtaagga tgacccattg caaatttaat gaatgggccc   2221

 tttaagaaag atacgtatgc acttttactg tgaaactttt gta                     2264




      <210> 276
      <211> 4176
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(4126)

      <400> 276
 gtacgcctga cgtaccggtc cggaattccc gggtcgacga tttcgtgtgg acagtcccct     60

 gcccacgggg gaagcaggcg ggccccccag cacccgggag gccgagctga agctgcggct    120

 aaagctggtg gaggaggaag ccaacatctt gggccggaag atcgtggagc tggaggtgga    180

 gaaccgtggc ctcaaggcag ag atg gag gac atg cgg ggc cag cag gag cgg     232
                          Met Glu Asp Met Arg Gly Gln Gln Glu Arg
                            1               5                  10

 gag ggc ccg ggt cgg gac cac gca ccc agc att cct acc tca ccc ttc      280
 Glu Gly Pro Gly Arg Asp His Ala Pro Ser Ile Pro Thr Ser Pro Phe
                  15                  20                  25

 ggt gac tcc ctg gag tcc tcc act gag ctc cgc cgc cac ctg cag ttt      328
 Gly Asp Ser Leu Glu Ser Ser Thr Glu Leu Arg Arg His Leu Gln Phe
              30                  35                  40

 gta gaa gag gaa gcg gag ttg ctc cgg agg tcc atc tcc gag atc gaa      376
 Val Glu Glu Glu Ala Glu Leu Leu Arg Arg Ser Ile Ser Glu Ile Glu
          45                  50                  55

 gac cac aac cgg caa ctg acc cac gag ctc agc aag ttt aag ttt gag      424
 Asp His Asn Arg Gln Leu Thr His Glu Leu Ser Lys Phe Lys Phe Glu
      60                  65                  70

 cct ccc cgg gag ccg ggc tgg cta gga gag ggt gca agt cct ggt gcc      472
 Pro Pro Arg Glu Pro Gly Trp Leu Gly Glu Gly Ala Ser Pro Gly Ala
  75                  80                  85                  90

 ggg ggt ggg gcc ccc ctg cag gag gag ctg aag tca gcc agg ctg cag      520
 Gly Gly Gly Ala Pro Leu Gln Glu Glu Leu Lys Ser Ala Arg Leu Gln
                  95                 100                 105

 atc agc gag ctc agc ggc aag gtg ctc aaa ctg cag cac gag aac cac      568
 Ile Ser Glu Leu Ser Gly Lys Val Leu Lys Leu Gln His Glu Asn His
             110                 115                 120

 gcg ctg ctg tcc aac atc cag cgc tgc gac ctg gca gcc cac ctg ggg      616
 Ala Leu Leu Ser Asn Ile Gln Arg Cys Asp Leu Ala Ala His Leu Gly
         125                 130                 135

 ctg cgt gcc ccc agt ccc cgg gac agc gat gcc gag agt gat gcg ggc      664
 Leu Arg Ala Pro Ser Pro Arg Asp Ser Asp Ala Glu Ser Asp Ala Gly
     140                 145                 150

 aag aag gag agt gat ggg gag gag agc cgc ctg ccc cag ccc aag cgg      712
 Lys Lys Glu Ser Asp Gly Glu Glu Ser Arg Leu Pro Gln Pro Lys Arg
 155                 160                 165                 170

 gaa ggg cct gtt ggc ggg gag agt gac tcg gag gag atg ttt gag aag      760
 Glu Gly Pro Val Gly Gly Glu Ser Asp Ser Glu Glu Met Phe Glu Lys
                 175                 180                 185

 acg tcg ggc ttc ggg agc ggg aag cca tcg gag gcc agc gag cca tgc      808
 Thr Ser Gly Phe Gly Ser Gly Lys Pro Ser Glu Ala Ser Glu Pro Cys
             190                 195                 200

 ccc acg gag ctc ctg aag gcc cgg gag gac tct gag tac cta gtg acc      856
 Pro Thr Glu Leu Leu Lys Ala Arg Glu Asp Ser Glu Tyr Leu Val Thr
         205                 210                 215

 cta aaa cac gag gcc cag cgg cta gag cgg acg gtg gag cgc ctc atc      904
 Leu Lys His Glu Ala Gln Arg Leu Glu Arg Thr Val Glu Arg Leu Ile
     220                 225                 230

 acg gac acc gac agc ttc ctc cat gat gcg ggg ctg cgg ggt ggt gcg      952
 Thr Asp Thr Asp Ser Phe Leu His Asp Ala Gly Leu Arg Gly Gly Ala
 235                 240                 245                 250

 ccc tta ccg ggg cct ggc ctc cag ggc gaa gag gag cag ggt gag ggg     1000
 Pro Leu Pro Gly Pro Gly Leu Gln Gly Glu Glu Glu Gln Gly Glu Gly
                 255                 260                 265

 gac cag cag gag ccc cag ctg ctg ggg acc atc aac gcc aag atg aag     1048
 Asp Gln Gln Glu Pro Gln Leu Leu Gly Thr Ile Asn Ala Lys Met Lys
             270                 275                 280

 gct ttc aag aaa gag ctg cag gcc ttc ctg gag cag gtg aac cgc att     1096
 Ala Phe Lys Lys Glu Leu Gln Ala Phe Leu Glu Gln Val Asn Arg Ile
         285                 290                 295

 ggg gat ggc cta tcc ccc ttg ccc cac ctc aca gag tcc tct agc ttc     1144
 Gly Asp Gly Leu Ser Pro Leu Pro His Leu Thr Glu Ser Ser Ser Phe
     300                 305                 310

 ctc tcc act gtg act tcc gtg tcc cgg gac tcc ccc atc ggg aac ctg     1192
 Leu Ser Thr Val Thr Ser Val Ser Arg Asp Ser Pro Ile Gly Asn Leu
 315                 320                 325                 330

 ggg aag gag ctg ggc cca gac ttg cag tcc aga ctg aaa gag cag ctg     1240
 Gly Lys Glu Leu Gly Pro Asp Leu Gln Ser Arg Leu Lys Glu Gln Leu
                 335                 340                 345

 gag tgg cag ctc ggg ccg gcc cga ggg gac gag cgg gag agc ctg cgc     1288
 Glu Trp Gln Leu Gly Pro Ala Arg Gly Asp Glu Arg Glu Ser Leu Arg
             350                 355                 360

 ctc cga gcc gcg cgg gag ctg cac cgc cgc gca gac ggg gac acc ggg     1336
 Leu Arg Ala Ala Arg Glu Leu His Arg Arg Ala Asp Gly Asp Thr Gly
         365                 370                 375

 agc cac ggg ctg gga ggc cag acc tgc ttc agc ctg gag atg gag gag     1384
 Ser His Gly Leu Gly Gly Gln Thr Cys Phe Ser Leu Glu Met Glu Glu
     380                 385                 390

 gag cac ctc tat gcc ttg agg tgg aaa gaa ctg gaa atg cac agc ctg     1432
 Glu His Leu Tyr Ala Leu Arg Trp Lys Glu Leu Glu Met His Ser Leu
 395                 400                 405                 410

 gct ttg caa aac acc ctc cat gag cga acc tgg agt gat gag aag aat     1480
 Ala Leu Gln Asn Thr Leu His Glu Arg Thr Trp Ser Asp Glu Lys Asn
                 415                 420                 425

 ctg atg cag cag gag ctc cgg tcc ttg aag cag aac att ttc ctc ttc     1528
 Leu Met Gln Gln Glu Leu Arg Ser Leu Lys Gln Asn Ile Phe Leu Phe
             430                 435                 440

 tac gtc aaa ctc agg tgg ctg ctg aaa cac tgg cgg caa ggg aag cag     1576
 Tyr Val Lys Leu Arg Trp Leu Leu Lys His Trp Arg Gln Gly Lys Gln
         445                 450                 455

 atg gag gag gaa gga gag gag ttc act gag ggt gaa cat cca gag acc     1624
 Met Glu Glu Glu Gly Glu Glu Phe Thr Glu Gly Glu His Pro Glu Thr
     460                 465                 470

 ctc tcc agg ctc ggg gag ctt gga gtc cag ggg ggt cac cag gcg gat     1672
 Leu Ser Arg Leu Gly Glu Leu Gly Val Gln Gly Gly His Gln Ala Asp
 475                 480                 485                 490

 ggc cca gac cac gac agt gac cga ggc tgt ggc ttt cca gtg ggg gag     1720
 Gly Pro Asp His Asp Ser Asp Arg Gly Cys Gly Phe Pro Val Gly Glu
                 495                 500                 505

 cac tcc cca cac tcc cgg gtg cag att gga gat cac agc ttg cgg ctg     1768
 His Ser Pro His Ser Arg Val Gln Ile Gly Asp His Ser Leu Arg Leu
             510                 515                 520

 cag acc gcg gac agg gga cag ccc cac aaa cag gtg gtg gaa aac cag     1816
 Gln Thr Ala Asp Arg Gly Gln Pro His Lys Gln Val Val Glu Asn Gln
         525                 530                 535

 cag ctg ttc agc gcc ttc aag gcc ttg ctg gag gac ttc cgt gcg gag     1864
 Gln Leu Phe Ser Ala Phe Lys Ala Leu Leu Glu Asp Phe Arg Ala Glu
     540                 545                 550

 ctg cgg gag gat gag cgt gcc cga cta cgg ctg cag cag caa tat gcc     1912
 Leu Arg Glu Asp Glu Arg Ala Arg Leu Arg Leu Gln Gln Gln Tyr Ala
 555                 560                 565                 570

 agc gac aag gcg gcc tgg gac gtg gag tgg gcc gtg ctc aag tgc cgt     1960
 Ser Asp Lys Ala Ala Trp Asp Val Glu Trp Ala Val Leu Lys Cys Arg
                 575                 580                 585

 ctg gaa cag ctg gaa gag aag act gag aac aag ttg gga gaa cta ggc     2008
 Leu Glu Gln Leu Glu Glu Lys Thr Glu Asn Lys Leu Gly Glu Leu Gly
             590                 595                 600

 tcc tcc gct gag agc aag ggg gcc ttg aag aag gag aga gag gtg cac     2056
 Ser Ser Ala Glu Ser Lys Gly Ala Leu Lys Lys Glu Arg Glu Val His
         605                 610                 615

 cag aag ctc ctg gca gac agt cac agc ctg gtc atg gac ctg cgc tgg     2104
 Gln Lys Leu Leu Ala Asp Ser His Ser Leu Val Met Asp Leu Arg Trp
     620                 625                 630

 cag atc cat cac agc gag aag aac tgg aac cgg gag aag gtg gaa ctt     2152
 Gln Ile His His Ser Glu Lys Asn Trp Asn Arg Glu Lys Val Glu Leu
 635                 640                 645                 650

 ctc gac cgc ctg gac aga gat cgg cag gag tgg gag cgg cag aag aag     2200
 Leu Asp Arg Leu Asp Arg Asp Arg Gln Glu Trp Glu Arg Gln Lys Lys
                 655                 660                 665

 gaa ttc ttg tgg agg ata gag cag ttg cag aaa gag aac agt ccc cgg     2248
 Glu Phe Leu Trp Arg Ile Glu Gln Leu Gln Lys Glu Asn Ser Pro Arg
             670                 675                 680

 aga ggt ggc agt ttc ctc tgt gat caa aaa gac ggc aac gtt cgc ccc     2296
 Arg Gly Gly Ser Phe Leu Cys Asp Gln Lys Asp Gly Asn Val Arg Pro
         685                 690                 695

 ttt ccc cac cag gga agc ctc cgc atg ccc cgt cca gtg gcc atg tgg     2344
 Phe Pro His Gln Gly Ser Leu Arg Met Pro Arg Pro Val Ala Met Trp
     700                 705                 710

 cct tgt gca gat gct gac tcc atc ccg ttt gaa gac cgg ccg ctg tcc     2392
 Pro Cys Ala Asp Ala Asp Ser Ile Pro Phe Glu Asp Arg Pro Leu Ser
 715                 720                 725                 730

 aag ctg aag gag tcg gac agg tgc tcg gcc agt gag aat ctc tac ctg     2440
 Lys Leu Lys Glu Ser Asp Arg Cys Ser Ala Ser Glu Asn Leu Tyr Leu
                 735                 740                 745

 gat gcc ttg tcc ctg gat gac gag cca gaa gag cca cca gcc cac agg     2488
 Asp Ala Leu Ser Leu Asp Asp Glu Pro Glu Glu Pro Pro Ala His Arg
             750                 755                 760

 ccc gag agg gag ttc agg aac cgc ctc cct gag gaa gaa gaa aat cac     2536
 Pro Glu Arg Glu Phe Arg Asn Arg Leu Pro Glu Glu Glu Glu Asn His
         765                 770                 775

 aaa gga aat ctt caa agg gcg gtg tcc gtg tcc tcc atg tct gag ttc     2584
 Lys Gly Asn Leu Gln Arg Ala Val Ser Val Ser Ser Met Ser Glu Phe
     780                 785                 790

 cag cgt cta atg gac atc tcc ccc ttc ctg cct gag aag ggc ctg ccg     2632
 Gln Arg Leu Met Asp Ile Ser Pro Phe Leu Pro Glu Lys Gly Leu Pro
 795                 800                 805                 810

 tcc acc agc agc aag gag gat gtc acc cca ccc ctg tct cca gac gac     2680
 Ser Thr Ser Ser Lys Glu Asp Val Thr Pro Pro Leu Ser Pro Asp Asp
                 815                 820                 825

 ctc aag tac atc gag gag ttc aac aag agc tgg gac tac aca ccc aac     2728
 Leu Lys Tyr Ile Glu Glu Phe Asn Lys Ser Trp Asp Tyr Thr Pro Asn
             830                 835                 840

 agg ggc cac aat ggt ggg ggg ccg gac ctt tgg gcc gac agg acc gag     2776
 Arg Gly His Asn Gly Gly Gly Pro Asp Leu Trp Ala Asp Arg Thr Glu
         845                 850                 855

 gtg ggg cgg gca ggg cac gag gac agc aca gag cct ttc ccc gac tcc     2824
 Val Gly Arg Ala Gly His Glu Asp Ser Thr Glu Pro Phe Pro Asp Ser
     860                 865                 870

 tcc tgg tac cta acc aca agt gtc acc atg acc acg gac acc atg acc     2872
 Ser Trp Tyr Leu Thr Thr Ser Val Thr Met Thr Thr Asp Thr Met Thr
 875                 880                 885                 890

 agc cca gag cac tgc cag aag cag cca ctg cgg agc cac gtc ctc acc     2920
 Ser Pro Glu His Cys Gln Lys Gln Pro Leu Arg Ser His Val Leu Thr
                 895                 900                 905

 gag cag tcg ggg ttg cgc gtg tta cac agc ccg cct gcc gtg cgc agg     2968
 Glu Gln Ser Gly Leu Arg Val Leu His Ser Pro Pro Ala Val Arg Arg
             910                 915                 920

 gtc gac agc atc acg gcg gca ggt ggt gag ggt ccc ttt ccc aca agc     3016
 Val Asp Ser Ile Thr Ala Ala Gly Gly Glu Gly Pro Phe Pro Thr Ser
         925                 930                 935

 aga gcc aga ggg agc ccg gga gac acc aag ggg ggc cct cca gaa ccc     3064
 Arg Ala Arg Gly Ser Pro Gly Asp Thr Lys Gly Gly Pro Pro Glu Pro
     940                 945                 950

 atg ctc agc agg tgg cct tgc acc tcc ccc agg cac tcc cgg gac tat     3112
 Met Leu Ser Arg Trp Pro Cys Thr Ser Pro Arg His Ser Arg Asp Tyr
 955                 960                 965                 970

 gtg gag ggg gca cgg cgc ccc ctt gat agt ccc ctc tgt acc tcc ctg     3160
 Val Glu Gly Ala Arg Arg Pro Leu Asp Ser Pro Leu Cys Thr Ser Leu
                 975                 980                 985

 ggg ttt gcc tcc cca ctg cac agc ctg gag atg tcc aag aac ttg agt     3208
 Gly Phe Ala Ser Pro Leu His Ser Leu Glu Met Ser Lys Asn Leu Ser
             990                 995                1000

 gat gac atg aag gag gtg gcc ttc tct gtc agg aat gcc atc tgc tcc     3256
 Asp Asp Met Lys Glu Val Ala Phe Ser Val Arg Asn Ala Ile Cys Ser
        1005                1010                1015

 ggc cct ggc gag ctg caa gtc aag gac atg gcc tgc cag acc aat ggg     3304
 Gly Pro Gly Glu Leu Gln Val Lys Asp Met Ala Cys Gln Thr Asn Gly
    1020                1025                1030

 tcc cgg acg atg ggg acc cag act gtt cag acc atc agt gtg ggc ttg     3352
 Ser Arg Thr Met Gly Thr Gln Thr Val Gln Thr Ile Ser Val Gly Leu
1035                1040                1045                1050

 cag act gaa gcc ctg cgt ggc agc ggt gtc acc agc agc ccc cac aag     3400
 Gln Thr Glu Ala Leu Arg Gly Ser Gly Val Thr Ser Ser Pro His Lys
                1055                1060                1065

 tgt ctc act cca aag gct ggg ggc ggt gct aca ccc gtg tcg tct cct     3448
 Cys Leu Thr Pro Lys Ala Gly Gly Gly Ala Thr Pro Val Ser Ser Pro
            1070                1075                1080

 tcc cgg agc ctt agg agc aga cag gtg gcc cct gcc atc gag aag gtg     3496
 Ser Arg Ser Leu Arg Ser Arg Gln Val Ala Pro Ala Ile Glu Lys Val
        1085                1090                1095

 cag gcc aag ttt gaa cgc aca tgc tgc tcc ccc aag tat ggt tct ccc     3544
 Gln Ala Lys Phe Glu Arg Thr Cys Cys Ser Pro Lys Tyr Gly Ser Pro
    1100                1105                1110

 aag ctg cag agg aag ccc ctc ccc aaa gcc gac cag cca aat aac agg     3592
 Lys Leu Gln Arg Lys Pro Leu Pro Lys Ala Asp Gln Pro Asn Asn Arg
1115                1120                1125                1130

 acg tca cca ggg atg gcc cag aaa ggg tac agt gag tca gcc tgg gcc     3640
 Thr Ser Pro Gly Met Ala Gln Lys Gly Tyr Ser Glu Ser Ala Trp Ala
                1135                1140                1145

 cgc tcc acc acc aca agg gag agc ccc gtg cac acc acc att aat gat     3688
 Arg Ser Thr Thr Thr Arg Glu Ser Pro Val His Thr Thr Ile Asn Asp
            1150                1155                1160

 ggc ctc tcc agc ctc ttc aac atc att gac cac agc ccc gtg gtg cag     3736
 Gly Leu Ser Ser Leu Phe Asn Ile Ile Asp His Ser Pro Val Val Gln
        1165                1170                1175

 gac ccc ttc cag aag ggg ctg cgg gcc ggc agt cgg tct cgc tca gca     3784
 Asp Pro Phe Gln Lys Gly Leu Arg Ala Gly Ser Arg Ser Arg Ser Ala
    1180                1185                1190

 gag ccc cga cca gag ctg ggc cca ggc cag gaa aca ggc acc aat tcc     3832
 Glu Pro Arg Pro Glu Leu Gly Pro Gly Gln Glu Thr Gly Thr Asn Ser
1195                1200                1205                1210

 cga gga agg tcg cct agc ccc att ggg gtg ggg tca gag atg tgc agg     3880
 Arg Gly Arg Ser Pro Ser Pro Ile Gly Val Gly Ser Glu Met Cys Arg
                1215                1220                1225

 gag gaa ggg gga gag ggc acg cca gtg aag cag gac tta tct gct ccc     3928
 Glu Glu Gly Gly Glu Gly Thr Pro Val Lys Gln Asp Leu Ser Ala Pro
            1230                1235                1240

 cct ggc tac acc ctc act gag aac gtg gcc cgg atc ctc aac aag aag     3976
 Pro Gly Tyr Thr Leu Thr Glu Asn Val Ala Arg Ile Leu Asn Lys Lys
        1245                1250                1255

 ctg ctg gaa cat gcc tta aag gag gag agg agg cag gct gcc cac ggg     4024
 Leu Leu Glu His Ala Leu Lys Glu Glu Arg Arg Gln Ala Ala His Gly
    1260                1265                1270

 ccc ccg ggt ctc cac agt gac agc cac tcg ctg ggg gac aca gcc gag     4072
 Pro Pro Gly Leu His Ser Asp Ser His Ser Leu Gly Asp Thr Ala Glu
1275                1280                1285                1290

 cca ggg ccc atg gag aac caa act gtc ttg cta act gcc ccc tgg gga     4120
 Pro Gly Pro Met Glu Asn Gln Thr Val Leu Leu Thr Ala Pro Trp Gly
                1295                1300                1305

 ctc tag ccctgcctgc ctcacgctga actaccttgt tctgcactag ctccatccct      4176
 Leu 






      <210> 277
      <211> 437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(299)

      <400> 277
 ttttcgttgg cgctttatag ctacacagtg ct  atg cca gag cca gcg aag tct      53
                                      Met Pro Glu Pro Ala Lys Ser
                                        1               5

 gct ccc gcc ccg aaa aag ggc tcc aag aag gcg gtg act aag gcg caa      101
 Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys Ala Val Thr Lys Ala Gln
          10                  15                  20

 aaa aaa gac ggc aag aag cgc aag cgc agc cgc aag gag agc tat tcc      149
 Lys Lys Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys Glu Ser Tyr Ser
      25                  30                  35

 atc tat gtg tac aag gtt ctg aag cag gtc cac cct gac acc ggc att      197
 Ile Tyr Val Tyr Lys Val Leu Lys Gln Val His Pro Asp Thr Gly Ile
  40                  45                  50                  55

 tcg tcc aag gcc atg ggc atc atg aat tcg ttt gtg aac gac att ttc      245
 Ser Ser Lys Ala Met Gly Ile Met Asn Ser Phe Val Asn Asp Ile Phe
                  60                  65                  70

 gag cgc atc gca ggt gga gtg gct gaa act tct cag cag gcg cat cta      293
 Glu Arg Ile Ala Gly Gly Val Ala Glu Thr Ser Gln Gln Ala His Leu
              75                  80                  85

 cac tag tgacctgagg agagaaaccc taaccccaca atggctgcat cttctctgaa       349
 His 


 gacgagactg atgctcatct ttgaaatgaa gggcagtgtg tgcatttctc catgaaggta    409

 tccagaaaca gccatgccag agctgctg                                       437




      <210> 278
      <211> 831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(565)

      <400> 278
 tgacagcacc agc   atg tct tac agt gtg acc ctg act ggg ccc ggg ccc      49
                  Met Ser Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro
                    1               5                  10

 tgg ggc ttc cgt ctg cag ggg ggc aag gac ttc aac atg ccc ctc act       97
 Trp Gly Phe Arg Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr
          15                  20                  25

 atc tcc cgg atc aca cca ggc agc aag gca gcc cag tcc cag ctc agc      145
 Ile Ser Arg Ile Thr Pro Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser
      30                  35                  40

 cag ggt gac ctc gta gtg gcc att gac ggc gtc aac aca gac acc atg      193
 Gln Gly Asp Leu Val Val Ala Ile Asp Gly Val Asn Thr Asp Thr Met
  45                  50                  55                  60

 acc cac ctg gaa gcc cag aac aag atc aag tct gcc agc tac aac ttg      241
 Thr His Leu Glu Ala Gln Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu
                  65                  70                  75

 agc ctc acc ctg cag aaa tca aag cgt ccc att ccc atc tcc acg aca      289
 Ser Leu Thr Leu Gln Lys Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr
              80                  85                  90

 gca cct cca gtc cag acc cct ctg ccg gtg atc cct cac cag aag gtg      337
 Ala Pro Pro Val Gln Thr Pro Leu Pro Val Ile Pro His Gln Lys Val
          95                 100                 105

 gta gtc aac tct cca gcc aac gcc gac tac cag gaa cgc ttc aac ccc      385
 Val Val Asn Ser Pro Ala Asn Ala Asp Tyr Gln Glu Arg Phe Asn Pro
     110                 115                 120

 agt gcc ctg aag gac tcg gcc ctg tcc acc cac aag ccc atc gag gtg      433
 Ser Ala Leu Lys Asp Ser Ala Leu Ser Thr His Lys Pro Ile Glu Val
 125                 130                 135                 140

 aag ggg ctg ggc ggc gag gcc acc atc atc cat gcg cag tac aac acg      481
 Lys Gly Leu Gly Gly Glu Ala Thr Ile Ile His Ala Gln Tyr Asn Thr
                 145                 150                 155

 ccc atc agc atg tat tcc cag gat gcc atc atg gat gcc atc gct ggg      529
 Pro Ile Ser Met Tyr Ser Gln Asp Ala Ile Met Asp Ala Ile Ala Gly
             160                 165                 170

 cag gcc caa gcc caa ggc agt gac ttc agt ggg taa gcgc ctccctcctc      579
 Gln Ala Gln Ala Gln Gly Ser Asp Phe Ser Gly 
         175                 180

 caccgccact cagtgcctcc agagcccgag gggtatgggc cattgggcac catcgggacc    639

 agctttcttc cctcacgttg gacctcctgg aggcatggcc cttggagggg agccagcctt    699

 caccagggcc ttctggaacg tgggtatcct ctcttcagac cctctccatg gtcagcttta    759

 ggagaagggt ggagaaatgc agaaaatggt ggctcctcaa agtgcttttc acagcctctg    819

 cattttccca gg                                                        831




      <210> 279
      <211> 1950
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (411)..(1262)

      <400> 279
 tcacaggagc aaggagacca gagcattctc accaaccagg ccagttcccc ttcctccccc     60

 ctggggggtg ctgggtgccg gacacccctc cccaggggct atattagccg tgtgagtcat    120

 ggtggaccgg ctgggaggcg gcaggctggc aggcacagtg tagggttaca gtccatttat    180

 gggcgcagcc gaaggcagat atcagtgtcg atggcattcg ctcccagcta ttcttaggag    240

 cctctcaaga gctccacgca gcccggctgg gcagcaaggg acagaacagg caaggctggg    300

 ggtcaggggc aggggcagag gtgtggaccg ggcaggcgga gtgcctgagt gccctctcac    360

 tcaaccctct ctaccctttg tctgcagagg cggccgctga cagcaccagc   atg tct     416
                                                          Met Ser
                                                            1

 tac agt gtg acc ctg act ggg ccc ggg ccc tgg ggc ttc cgt ctg cag      464
 Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro Trp Gly Phe Arg Leu Gln
           5                  10                  15

 ggg ggc aag gac ttc aac atg ccc ctc act atc tcc cgg atc aca cca      512
 Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Arg Ile Thr Pro
      20                  25                  30

 ggc agc aag gca gcc cag tcc cag ctc agc cag ggt gac ctc gtg gtg      560
 Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser Gln Gly Asp Leu Val Val
  35                  40                  45                  50

 gcc att gac ggc gtc aac aca gac acc atg acc cac ctg gaa gcc cag      608
 Ala Ile Asp Gly Val Asn Thr Asp Thr Met Thr His Leu Glu Ala Gln
                  55                  60                  65

 aac aag atc aag tct gcc agc tac aac ttg agc ctc acc ctg cag aaa      656
 Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu Ser Leu Thr Leu Gln Lys
              70                  75                  80

 tca aag cgt ccc att ccc atc tcc acg aca gca cct cca gtc cag acc      704
 Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr Ala Pro Pro Val Gln Thr
          85                  90                  95

 cct ctg ccg gtg atc cct cac cag aag gtg gta gtc aac tct cca gcc      752
 Pro Leu Pro Val Ile Pro His Gln Lys Val Val Val Asn Ser Pro Ala
     100                 105                 110

 aac gcc gac tac cag gaa cgc ttc aac ccc agt gcc ctg aag gac tcg      800
 Asn Ala Asp Tyr Gln Glu Arg Phe Asn Pro Ser Ala Leu Lys Asp Ser
 115                 120                 125                 130

 gcc ctg tcc acc cac aag ccc atc gag gtg aag ggg ctg ggc ggc aag      848
 Ala Leu Ser Thr His Lys Pro Ile Glu Val Lys Gly Leu Gly Gly Lys
                 135                 140                 145

 gcc acc atc atc cat gcg cag tac aac acg ccc atc agc atg tat tcc      896
 Ala Thr Ile Ile His Ala Gln Tyr Asn Thr Pro Ile Ser Met Tyr Ser
             150                 155                 160

 cag gat gcc atc atg gat gcc atc gct ggg cag gcc caa gcc caa ggc      944
 Gln Asp Ala Ile Met Asp Ala Ile Ala Gly Gln Ala Gln Ala Gln Gly
         165                 170                 175

 agt gac ttc agt ggg agc ctc cct att aag gac ctt gcc gta gac agc      992
 Ser Asp Phe Ser Gly Ser Leu Pro Ile Lys Asp Leu Ala Val Asp Ser
     180                 185                 190

 gcc tct ccc gtc tac cag gct gtg att aag agc cag aac aag cca gaa     1040
 Ala Ser Pro Val Tyr Gln Ala Val Ile Lys Ser Gln Asn Lys Pro Glu
 195                 200                 205                 210

 gat gag gct gac gag tgg gca cgc cgt tcc tcc aac ctg cag tct cgc     1088
 Asp Glu Ala Asp Glu Trp Ala Arg Arg Ser Ser Asn Leu Gln Ser Arg
                 215                 220                 225

 tcc ttc cgc atc ctg gcc cag atg acg ggg aca gaa ttc atg caa gac     1136
 Ser Phe Arg Ile Leu Ala Gln Met Thr Gly Thr Glu Phe Met Gln Asp
             230                 235                 240

 cct gat gaa gaa gct ctg cga agg tca agg gaa agg ttt gaa acg gaa     1184
 Pro Asp Glu Glu Ala Leu Arg Arg Ser Arg Glu Arg Phe Glu Thr Glu
         245                 250                 255

 cgt aac agc cca cgt ttt gcc aaa ttg cgc aac tgg cac cat ggc ctt     1232
 Arg Asn Ser Pro Arg Phe Ala Lys Leu Arg Asn Trp His His Gly Leu
     260                 265                 270

 tca gcc caa atc ctt aat gtt aaa agc taa a aggctgcctg gaatcccccc     1283
 Ser Ala Gln Ile Leu Asn Val Lys Ser 
 275                 280

 accccaacag gctggactcc ctccatcctt acccccacac agatctggca tgtgagcccc   1343

 acggtgatgc ttgacaatgt ataactctgc tgggggcacc tctgatggcc aaccgcagca   1403

 tttctgtcct ctgcccaccc cagagctgat gctggggccc agccccctgc agctctgtac   1463

 ccaccaaacc tccccagggc aaccctcgcc accccccaaa tagcccgtag cccaatcccc   1523

 tgccctctgc acagggcctt agctgtagac cagagagggc aggaggggtt tgctggcata   1583

 acaccccaga accaagggaa atggatgggc cgctgctcag tttcccacca tcctcagctc   1643

 ctggcctcat cccctcctag aatgagtcac ccgtagatca gggtctgggg aagaggctga   1703

 tccctggcgc tgcccggctc cctcgctgcc ctctggagct cagggcagcc cggaataggg   1763

 ctctttgaag aggaagtaga agccccaggg taatgaggca gagacccctc ctggcagtgg   1823

 tgaggtgggg gcatgcaccc tcctttctgt accgtgtgtg ctggctccat agttctctct   1883

 tctgtacata taagcatgct tgttctgaaa taaagaagat ttgaagtgaa ccacaaaaaa   1943

 aaaaaaa                                                             1950




      <210> 280
      <211> 1949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(1272)

      <400> 280
 ccgaggccca ccactgccac cacccgccgc acgaccacca ggcgtccaac aaccacagtc     60

 cgaaccacta cgcggacaac caccaccacc acccccaaac ccaccactcc catccccacc    120

 tgtccccctg ggaccttgga acggcacgac gatgatggca acctgata atg agc tcc     177
                                                      Met Ser Ser
                                                        1

 aat ggg atc cca gag tgc tac gct gaa gaa gat gag ttc tca ggc ttg      225
 Asn Gly Ile Pro Glu Cys Tyr Ala Glu Glu Asp Glu Phe Ser Gly Leu
       5                  10                  15

 gag act gac act gca gta cct acg gaa gag gcc tac gtt ata tat gat      273
 Glu Thr Asp Thr Ala Val Pro Thr Glu Glu Ala Tyr Val Ile Tyr Asp
  20                  25                  30                  35

 gaa gat tat gaa ttt gag acg tca agg cca cca acc acc act gag cct      321
 Glu Asp Tyr Glu Phe Glu Thr Ser Arg Pro Pro Thr Thr Thr Glu Pro
                  40                  45                  50

 tcg acc act gct acc aca ccg agg gtg atc cca gag gaa ggc gcc atc      369
 Ser Thr Thr Ala Thr Thr Pro Arg Val Ile Pro Glu Glu Gly Ala Ile
              55                  60                  65

 agt tcc ttt cct gaa gaa gaa ttt gat ctg gct gga agg aaa cga ttt      417
 Ser Ser Phe Pro Glu Glu Glu Phe Asp Leu Ala Gly Arg Lys Arg Phe
          70                  75                  80

 gtt gct cct tac gtg acg tac cta aat aaa gac cca tca gcc ccg tgc      465
 Val Ala Pro Tyr Val Thr Tyr Leu Asn Lys Asp Pro Ser Ala Pro Cys
      85                  90                  95

 tct ctg act gat gca ctg gat cac ttc caa gtg gac agc ctg gat gaa      513
 Ser Leu Thr Asp Ala Leu Asp His Phe Gln Val Asp Ser Leu Asp Glu
 100                 105                 110                 115

 atc atc ccc aat gac ctg aag aag agt gat ctg cct ccc cag cat gct      561
 Ile Ile Pro Asn Asp Leu Lys Lys Ser Asp Leu Pro Pro Gln His Ala
                 120                 125                 130

 ccc cgc aac atc acc gtg gtg gcc gtg gaa ggt tgc cac tca ttt gtc      609
 Pro Arg Asn Ile Thr Val Val Ala Val Glu Gly Cys His Ser Phe Val
             135                 140                 145

 att gtg gac tgg gac aaa gcc acc cca gga gat gtg gtc aca ggt tac      657
 Ile Val Asp Trp Asp Lys Ala Thr Pro Gly Asp Val Val Thr Gly Tyr
         150                 155                 160

 ttg gtt tac agt gca tcc tat gaa gac ttc atc agg aac aag tgg tcc      705
 Leu Val Tyr Ser Ala Ser Tyr Glu Asp Phe Ile Arg Asn Lys Trp Ser
     165                 170                 175

 act caa gct tca tca gta act cac ttg ccc att gag aac cta aag ccc      753
 Thr Gln Ala Ser Ser Val Thr His Leu Pro Ile Glu Asn Leu Lys Pro
 180                 185                 190                 195

 aac acg agg tat tat ttt aaa gtg caa gca caa aat cct cat ggc tac      801
 Asn Thr Arg Tyr Tyr Phe Lys Val Gln Ala Gln Asn Pro His Gly Tyr
                 200                 205                 210

 gga cct atc agc cct tcg gtc tca ttt gtc acc gaa tca gat aat cct      849
 Gly Pro Ile Ser Pro Ser Val Ser Phe Val Thr Glu Ser Asp Asn Pro
             215                 220                 225

 ctg ctt gtt gtg agg ccc cca ggc ggt gag cct atc tgg atc cca ttc      897
 Leu Leu Val Val Arg Pro Pro Gly Gly Glu Pro Ile Trp Ile Pro Phe
         230                 235                 240

 gct ttc aaa cat gat ccc agc tac acg gac tgc cat gga cgg caa tat      945
 Ala Phe Lys His Asp Pro Ser Tyr Thr Asp Cys His Gly Arg Gln Tyr
     245                 250                 255

 gtg aag cgc acg tgg tat cga aag ttc gtg gga gtt gtt ctt tgt aat      993
 Val Lys Arg Thr Trp Tyr Arg Lys Phe Val Gly Val Val Leu Cys Asn
 260                 265                 270                 275

 tca ctg agg tat aaa atc tac ctc agt gac aac ctg aaa gat aca ttc     1041
 Ser Leu Arg Tyr Lys Ile Tyr Leu Ser Asp Asn Leu Lys Asp Thr Phe
                 280                 285                 290

 tac agc att gga gac agc tgg gga aga ggt gaa gac cat tgc caa ttt     1089
 Tyr Ser Ile Gly Asp Ser Trp Gly Arg Gly Glu Asp His Cys Gln Phe
             295                 300                 305

 gtg gat tca cac ctt gat gga aga aca ggg cct cag tcc tat gta gaa     1137
 Val Asp Ser His Leu Asp Gly Arg Thr Gly Pro Gln Ser Tyr Val Glu
         310                 315                 320

 gcc ctc cct act att caa ggc tac tat cgc cag tat cgt cag gag cct     1185
 Ala Leu Pro Thr Ile Gln Gly Tyr Tyr Arg Gln Tyr Arg Gln Glu Pro
     325                 330                 335

 gtc agg ttt ggg aac atc ggc ttc gga acc ccc tac tac tat gtg ggc     1233
 Val Arg Phe Gly Asn Ile Gly Phe Gly Thr Pro Tyr Tyr Tyr Val Gly
 340                 345                 350                 355

 tgg tac gag tgt ggg gtc tcc atc cct gga aag tgg taa tcacaggacc      1282
 Trp Tyr Glu Cys Gly Val Ser Ile Pro Gly Lys Trp 
                 360                 365

 gtcatgctgc aagcttgccc tgcccagccc caccaactaa gtcgcactag gggctgtgag   1342

 caaagacagc cagcatgctc agccccgctg ccctaggtgc caggaaggtc acagatggac   1402

 actggccatt ctggtcatct cagtctggaa ctcagtccca cttcttggcc tggacaatga   1462

 acaggattca gttttgctgt taactttgct tctctacttt tttttgtttg tttgtaatag   1522

 cacatcccag agacatcaga aaccagcaac tgattcagtg tgatttccag actttttagg   1582

 catgaaattc ggacacttca gtatttccag gaatagcata tgcacgctgt tcttgcttca   1642

 tggaatgcta catgctttct gtttttctca ttttggattt ctccaaaact aactgaattt   1702

 aagcttcagg tccctttgta tgcagtagaa aggaattatt aaaaacacca ccaaagaaaa   1762

 taaatatatc ctacttgaaa tttactctat ggacttaccc actgctagaa taaatgtatc   1822

 aaatcttatt tgtaaattct caattttgat atatatatgt atatatgcat atacatatcc   1882

 acacttgtct gcaagaatat tgattaaaat tgctaaattt gtacttgttc accagaaaaa   1942

 aaaaaaa                                                             1949




      <210> 281
      <211> 816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(734)

      <400> 281
 taagcttgcg gccgctcagc    atg tcc ggg cac ttt ctg ctc gca ccc atc      50
                          Met Ser Gly His Phe Leu Leu Ala Pro Ile
                            1               5                  10

 ccc gag tcc tcc tcg gac tac cta ctg ccc aag gac atc aaa ctg gcg       98
 Pro Glu Ser Ser Ser Asp Tyr Leu Leu Pro Lys Asp Ile Lys Leu Ala
                  15                  20                  25

 gtg ctg ggc gcc ggc cgc gtg ggc aag agc gca atg atc gtg cgc ttc      146
 Val Leu Gly Ala Gly Arg Val Gly Lys Ser Ala Met Ile Val Arg Phe
              30                  35                  40

 ctg acc aag aga ttc att gga gac tat gaa ccg aat aca ggc aag ctg      194
 Leu Thr Lys Arg Phe Ile Gly Asp Tyr Glu Pro Asn Thr Gly Lys Leu
          45                  50                  55

 tat tca cgg ctg gtc tat gtc gag ggg gac cag ctc tcc ctg cag atc      242
 Tyr Ser Arg Leu Val Tyr Val Glu Gly Asp Gln Leu Ser Leu Gln Ile
      60                  65                  70

 cag gat act ccc ggg ggc gtc cag atc caa gac agc ctc ccc cag gtc      290
 Gln Asp Thr Pro Gly Gly Val Gln Ile Gln Asp Ser Leu Pro Gln Val
  75                  80                  85                  90

 gtc gat tcc ctg tcc aaa tgc gtg cag tgg gcc gag ggt ttt ctg ctg      338
 Val Asp Ser Leu Ser Lys Cys Val Gln Trp Ala Glu Gly Phe Leu Leu
                  95                 100                 105

 gtc tat tcc atc aca gac tat gac agc tac ttg tcc atc cga ccc ctt      386
 Val Tyr Ser Ile Thr Asp Tyr Asp Ser Tyr Leu Ser Ile Arg Pro Leu
             110                 115                 120

 tat cag cac atc cgg aag gtc cac cct gac tct aaa gcc cct gtc atc      434
 Tyr Gln His Ile Arg Lys Val His Pro Asp Ser Lys Ala Pro Val Ile
         125                 130                 135

 atc gtg ggc aac aag ggg gac ctt ttg cat gcc cgg cag gtg cag aca      482
 Ile Val Gly Asn Lys Gly Asp Leu Leu His Ala Arg Gln Val Gln Thr
     140                 145                 150

 cag gac ggt att cag cta gcc aat gag ctg ggc agc ctg ttc ctt gaa      530
 Gln Asp Gly Ile Gln Leu Ala Asn Glu Leu Gly Ser Leu Phe Leu Glu
 155                 160                 165                 170

 att tcc act agc gaa aac tac gaa gat gtc tgt gat gtg ttt cag cat      578
 Ile Ser Thr Ser Glu Asn Tyr Glu Asp Val Cys Asp Val Phe Gln His
                 175                 180                 185

 ctc tgc aaa gaa gtg agc aag atg cac ggc ctc agt ggg gaa aga aga      626
 Leu Cys Lys Glu Val Ser Lys Met His Gly Leu Ser Gly Glu Arg Arg
             190                 195                 200

 aga gcc tcc atc atc cct cgg ccc cgc tct ccc aac atg cag gac ctg      674
 Arg Ala Ser Ile Ile Pro Arg Pro Arg Ser Pro Asn Met Gln Asp Leu
         205                 210                 215

 aag aga cgc ttc aag cag gct ctg tct ccc aaa gtc aaa gcc ccc tct      722
 Lys Arg Arg Phe Lys Gln Ala Leu Ser Pro Lys Val Lys Ala Pro Ser
     220                 225                 230

 gca ctg ggg tga act atctcagaca gatgcctctc ctttttaata cgcatttgtg      777
 Ala Leu Gly 
 235

 cagctaaaag actgggcttc tcgcttttta atcacacat                           816




      <210> 282
      <211> 1596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (376)..(1500)

      <400> 282
 gctgattttg gctgtatgcg attttatctt tctgcacaga catcagaccc tgtcctcagg     60

 atgtgatggg gcccctcccc catctcccat cctaccagcc tgtgtccagg tgggggtggg    120

 gcagggcaga caacagggtc cctgtgtctc gggcagcaat gctgccccct ttcctgcccc    180

 aacatcccca gcagacacaa gagatggaga ctatgagctg ctctcgtggc tgggtctcgg    240

 gggtcctgca ccctcaggag ctgacgctga cgcactccac tgcctgtcac caggaaccta    300

 cctcgcgcca tcttcatctc catcccactg gtgaccttcg tgtacacgtt caccaacatt    360

 gcctacttca cggcc atg tcc ccc cag gag ctg ctc tcc tcc aat gcg gtg     411
                  Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Val
                    1               5                  10

 gct gtg gtg agt ggg ccc ctg ctc ggt ccc tgg ctc ctg ccc agg ccc      459
 Ala Val Val Ser Gly Pro Leu Leu Gly Pro Trp Leu Leu Pro Arg Pro
          15                  20                  25

 ctg ccc cgg cct tac aca tgg cct ctc tac tgc gcc cac cca gac ctt      507
 Leu Pro Arg Pro Tyr Thr Trp Pro Leu Tyr Cys Ala His Pro Asp Leu
      30                  35                  40

 cgg gga gaa gct gct ggg cta ctt ttc ttg ggt cat gcc tgt ctc cgt      555
 Arg Gly Glu Ala Ala Gly Leu Leu Phe Leu Gly His Ala Cys Leu Arg
  45                  50                  55                  60

 ggc tct gtc aac ctt cgg agg gat caa tgg tta cct gtt cac cta ctc      603
 Gly Ser Val Asn Leu Arg Arg Asp Gln Trp Leu Pro Val His Leu Leu
                  65                  70                  75

 cag gtg act gca ctg ggg aga cgt ggg cat ggg gag gga agg ctg ggg      651
 Gln Val Thr Ala Leu Gly Arg Arg Gly His Gly Glu Gly Arg Leu Gly
              80                  85                  90

 tgc agg tgt gca cca gtc atg ccg tgg gcc aga gga agg gac acc tgc      699
 Cys Arg Cys Ala Pro Val Met Pro Trp Ala Arg Gly Arg Asp Thr Cys
          95                 100                 105

 cgg ggg agg ggt ctg cct gaa gct ggg atg atg atc cca cac ggt aac      747
 Arg Gly Arg Gly Leu Pro Glu Ala Gly Met Met Ile Pro His Gly Asn
     110                 115                 120

 aag tgt ctg atc aca act ggg agg caa aga aag caa gag gca ggc agg      795
 Lys Cys Leu Ile Thr Thr Gly Arg Gln Arg Lys Gln Glu Ala Gly Arg
 125                 130                 135                 140

 ctg gat gag ggg gag aac tgt cca gtg ggg ctg ctg ggc ccg gag cag      843
 Leu Asp Glu Gly Glu Asn Cys Pro Val Gly Leu Leu Gly Pro Glu Gln
                 145                 150                 155

 gag gtc aga ggc gac agc tta aga ggg aca tca ggt cca aag ctg aga      891
 Glu Val Arg Gly Asp Ser Leu Arg Gly Thr Ser Gly Pro Lys Leu Arg
             160                 165                 170

 ccc agg atg tgg cca gtg ccc ata tct gtc ccc aac gct agg ctg tgc      939
 Pro Arg Met Trp Pro Val Pro Ile Ser Val Pro Asn Ala Arg Leu Cys
         175                 180                 185

 ttc tct gga gcc cgc gag ggg cac ctg ccc agc ctg ctg gcc atg atc      987
 Phe Ser Gly Ala Arg Glu Gly His Leu Pro Ser Leu Leu Ala Met Ile
     190                 195                 200

 cac gtc aga cac tgc acc ccc atc ccc gcc ctc ctc gtc tgt tgc ggg     1035
 His Val Arg His Cys Thr Pro Ile Pro Ala Leu Leu Val Cys Cys Gly
 205                 210                 215                 220

 gcc aca gcc gtc atc atg ctc gtg ggc gac acg tac acg ctc atc aac     1083
 Ala Thr Ala Val Ile Met Leu Val Gly Asp Thr Tyr Thr Leu Ile Asn
                 225                 230                 235

 tat gtg tcc ttc atc aac tac ctc tgc tac ggc gtc acc atc cag ggc     1131
 Tyr Val Ser Phe Ile Asn Tyr Leu Cys Tyr Gly Val Thr Ile Gln Gly
             240                 245                 250

 cct gct gct gct gcg ctg gag gcg gcc tgc act cca cag gcc cat caa     1179
 Pro Ala Ala Ala Ala Leu Glu Ala Ala Cys Thr Pro Gln Ala His Gln
         255                 260                 265

 ggt gaa cct tct cat ccc cgt ggc gta ctt ggt ctt ctg ggc ctt cct     1227
 Gly Glu Pro Ser His Pro Arg Gly Val Leu Gly Leu Leu Gly Leu Pro
     270                 275                 280

 gct ggt ctt cag ctt cat ctc aga gcc tat ggt ctg tgg ggt cgg cgt     1275
 Ala Gly Leu Gln Leu His Leu Arg Ala Tyr Gly Leu Trp Gly Arg Arg
 285                 290                 295                 300

 cat cat cat cct tac ggg ggt gcc cat ttt ctt tct ggg agt gtt ctg     1323
 His His His Pro Tyr Gly Gly Ala His Phe Leu Ser Gly Ser Val Leu
                 305                 310                 315

 gag aag caa acc aaa gtg tgt gca cag act cac aga gtc cat gac aca     1371
 Glu Lys Gln Thr Lys Val Cys Ala Gln Thr His Arg Val His Asp Thr
             320                 325                 330

 ctg ggg cca gga gct gtg ttt cgt ggt cta ccc cca gga cgc ccc cga     1419
 Leu Gly Pro Gly Ala Val Phe Arg Gly Leu Pro Pro Gly Arg Pro Arg
         335                 340                 345

 aga gga gga gaa tgg ccc ctg ccc acc ctc cct gct gcc tgc cac aga     1467
 Arg Gly Gly Glu Trp Pro Leu Pro Thr Leu Pro Ala Ala Cys His Arg
     350                 355                 360

 caa gcc ctc gaa gcc aca atg aga ttt ttg tag agactgaa gcagttgttt     1518
 Gln Ala Leu Glu Ala Thr Met Arg Phe Leu 
 365                 370

 ctgtttacat gttgtttatt gaggaggtgt tttggcaaaa aagttttgtt ttgttttttt   1578

 ctggaaaaaa aagaaaaa                                                 1596




      <210> 283
      <211> 500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(357)

      <400> 283
 ggggcctgga tggtctaaga cgggctctca cgtatttggc tgttggttag ttggactagg     60

 agagcctcag ccgggtcatc tcatctcagc tgtatgtgac tctcaactta caagaagcta    120

 gaccaggctt ccccacatgg tggtctcagg ataacattcc aagaacgtga gagttgaagc    180

 tcccaacatc tcatttgtga aaga   atg tca caa tgt cag ccc aga ttc aag     231
                              Met Ser Gln Cys Gln Pro Arg Phe Lys
                                1               5

 att gag gaa ata gat tac acc tct aca tgg aag aag ata caa ggc cac      279
 Ile Glu Glu Ile Asp Tyr Thr Ser Thr Trp Lys Lys Ile Gln Gly His
  10                  15                  20                  25

 att gca aag gaa tgg aag gaa tta act gca gcc atc ttt gaa aaa gtt      327
 Ile Ala Lys Glu Trp Lys Glu Leu Thr Ala Ala Ile Phe Glu Lys Val
                  30                  35                  40

 cac cac acc cac aga ttc aga ttt ctg tga a aatctaataa aagtctagtt      378
 His His Thr His Arg Phe Arg Phe Leu 
              45                  50

 taaaagagga gcgaaatata tttggttctt tacttctttt catttcctgg aagtacatag    438

 gggttggttt ttgttttttt cattttacat gatgaattcc tatgttttcc tcttgcccac    498

 at                                                                   500




      <210> 284
      <211> 653
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(321)

      <400> 284
 aaggatcctt aattaaatta atcccccccc cccccaccta tcgtgggtcg agttgcttgg     60

 cggtcgtggt tccggaggtt cctcggg    atg tcg gtg gcc ttc gta ccg gac     111
                                  Met Ser Val Ala Phe Val Pro Asp
                                    1               5

 tgg ctg agg ggc aag gcg gaa gtc aat caa gag act atc cag cgg ctc      159
 Trp Leu Arg Gly Lys Ala Glu Val Asn Gln Glu Thr Ile Gln Arg Leu
      10                  15                  20

 ctt gag gag aat gac cag ctg atc cgc tgt att gtg gag tat cag aac      207
 Leu Glu Glu Asn Asp Gln Leu Ile Arg Cys Ile Val Glu Tyr Gln Asn
  25                  30                  35                  40

 aag ggc cgc ggg aac gag tgc gtg cag tac cag cat gtg tta cat aga      255
 Lys Gly Arg Gly Asn Glu Cys Val Gln Tyr Gln His Val Leu His Arg
                  45                  50                  55

 aat ctc att tat ttg gct acc att gca gat gcc agt cca acc agc act      303
 Asn Leu Ile Tyr Leu Ala Thr Ile Ala Asp Ala Ser Pro Thr Ser Thr
              60                  65                  70

 tca aaa gca atg gaa taa tctttc aaaagcaata gaataatctt ccatttggct      357
 Ser Lys Ala Met Glu 
          75

 gtcgtgagga gtaattgaat gtaatccatc tcttacaaaa tggagacagg gtctttacca    417

 actcaactgg ttaaaacatg aatgaaacct ctgtggctct ttcgaaacgt gaaaatgtga    477

 agaaagctac taacttagct gtattctcat gtaaatattt tttaaataat taagcaaatc    537

 cctcaataag ttgagcccag gtgtcctctt tcctgaactt ggagcatgtt tggataacaa    597

 agacatcact gggatgttca agtctacttt ttagtttcac ctgaagagga actcga        653




      <210> 285
      <211> 1074
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (238)..(615)

      <400> 285
 ctcgacgatt tcgtcccatc cctactcccc actcagtcct gctcagagcc ttcccacccc     60

 ttgtcttttc tctggtcagc tgcgtagtaa gtgagaaggg aggggctacc agaggcaggg    120

 aagggaggag cctttgggtt tataaattcc aaaaaggcca ctcaactcct agagctggat    180

 ccttgaaaat ctactctatc agctgctgtg gttgccacca ttctcaggac cctcgcc       237                                                                 
 atg aaa gcc ctt atg ctg ctc acc ctg tct gtt ctg ctc tgc tgg gtc      285
 Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val Leu Leu Cys Trp Val
   1               5                  10                  15

 tca gct gac att cgc tgt cac tcc tgc tac aag gtc cct gtg ctg ggc      333
 Ser Ala Asp Ile Arg Cys His Ser Cys Tyr Lys Val Pro Val Leu Gly
              20                  25                  30

 tgt gtg gac cgg cag tcc tgc cgc ctg gag cca gga cag caa tgc ctg      381
 Cys Val Asp Arg Gln Ser Cys Arg Leu Glu Pro Gly Gln Gln Cys Leu
          35                  40                  45

 aca aca cat gca tac ctt ggt aag atg tgg gtt ttc tcc aat ctg cgc      429
 Thr Thr His Ala Tyr Leu Gly Lys Met Trp Val Phe Ser Asn Leu Arg
      50                  55                  60

 tgt ggc aca cca gaa gag ccc tgt cag gag ggc ttc aac caa acc aac      477
 Cys Gly Thr Pro Glu Glu Pro Cys Gln Glu Gly Phe Asn Gln Thr Asn
  65                  70                  75                  80

 cgt aag ctg ggt ctg aca tat aac acc acc tgc tgc aac aag gac aac      525
 Arg Lys Leu Gly Leu Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp Asn
                  85                  90                  95

 tgc aac agc gca gga ccc cgg ccc act cca gcc ctg ggc ctt gtc ttc      573
 Cys Asn Ser Ala Gly Pro Arg Pro Thr Pro Ala Leu Gly Leu Val Phe
             100                 105                 110

 ctt acc tcc ttg gct ggc ctt ggc ctc tgg ctg ctg cac tga gactcat      622
 Leu Thr Ser Leu Ala Gly Leu Gly Leu Trp Leu Leu His 
         115                 120                 125

 tccattggct gcccctcctc ccacctgcct tggcctgagc ctctctccct gtgtctctgt    682

 atcccctggc tttacagaat cgtctctccc tagctcccat ttctttaatt aaacactgtt    742

 ccgagtggtc tcctcatccg tccttcccac ctcacaccct tcactctcct ttttctgggt    802

 cccttcccac ttccttccag gacctccatt ggctcctaga agggctcccc actttgcttc    862

 ctatactctg ctgtccccta cttgaggagg gattgggatc tgggcctgaa atggggcttc    922

 tgtgttgtcc ccagtgaagg ctcccacaag gacctgatga cctcactgta cagagctgac    982

 tccccaaatc caggctccca tatgtacccc atcccccata ctcacctctt tccattttga   1042

 gtaataaatg tctgagtctg aaaaaaaaaa aa                                 1074




      <210> 286
      <211> 783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (264)..(656)

      <400> 286
 ccgggtcgac ccacgcgtcc gctcctccct gtagctggct gatgtagctc gttgatatct     60

 gtgtggatag ggagctgtga cgagagcaag aggtcagaac acatccaggc tccttaaggg    120

 aaagcctctt tctgtttctg aaacttttca aagccaggga cttgtccaat ccaacctcct    180

 cacagttcct agctcctgag gctcagcgcc cttggcttct gtccgcccag ctcaaggtcc    240

 tgcagcattg ccactgctca gcc    atg ctc ctg ctg ctc gtc cca gcg ttc     290
                              Met Leu Leu Leu Leu Val Pro Ala Phe
                                1               5

 cag gtg att ttt acc ctg gga gga acc aga gcc cag tct gtg acc cag      338
 Gln Val Ile Phe Thr Leu Gly Gly Thr Arg Ala Gln Ser Val Thr Gln
  10                  15                  20                  25

 ctt gac agc caa gtc cct gtc ttt gaa gaa gcc cct gtg gag ctg agg      386
 Leu Asp Ser Gln Val Pro Val Phe Glu Glu Ala Pro Val Glu Leu Arg
                  30                  35                  40

 tgc aac tac tca tcg tct gtt tca gtg tat ctc ttc tgg tat gtg caa      434
 Cys Asn Tyr Ser Ser Ser Val Ser Val Tyr Leu Phe Trp Tyr Val Gln
              45                  50                  55

 tac ccc aac caa gga ctc cag cct ctc ctg aag tat tta tca gga tcc      482
 Tyr Pro Asn Gln Gly Leu Gln Pro Leu Leu Lys Tyr Leu Ser Gly Ser
          60                  65                  70

 acc ctg gtt aaa ggc atc aac ggt ttt gag gct gaa ttt aac aag agt      530
 Thr Leu Val Lys Gly Ile Asn Gly Phe Glu Ala Glu Phe Asn Lys Ser
      75                  80                  85

 caa act tcc ttc cac ttg agg aaa ccc tca gtc cat ata agc gac acg      578
 Gln Thr Ser Phe His Leu Arg Lys Pro Ser Val His Ile Ser Asp Thr
  90                  95                 100                 105

 gct gag tac ttc tgt gct gtg agt gac aca gtg cct gag act gca gga      626
 Ala Glu Tyr Phe Cys Ala Val Ser Asp Thr Val Pro Glu Thr Ala Gly
                 110                 115                 120

 gag ctg aac aca aac ctc ctg aga tgc tga g actttctgtg actcaagaac      677
 Glu Leu Asn Thr Asn Leu Leu Arg Cys 
             125                 130

 tcaacctgtg gagctttcaa gagggtccct tttttctgtg cccgttttga aggcacatag    737

 ggcagggtgg gacgaaatcg tcgacagcga agtcgacccg ggaatt                   783




      <210> 287
      <211> 2195
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1435)..(2100)

      <400> 287
 gtcccccccc cctcactaaa gggaataagc ttgcgaccga cctgcccaac ccaacccgca     60

 cggtccggaa gtcgccgagg ggccgggagc gggaggggac gtcgtcgtag agggccggag    120

 cgggcgggcg gcgacggacc cggctcccgc gcaggacgga gccgtggctc aggtcggccc    180

 ctccccaaca ccaccccggg cctccgcccc ttcctgggcc tctcggtgga gcagggaccc    240

 gaaccggtgc ccatccagtc cggtgccatc tgaagccccc ttcccagaaa atgagccaca    300

 gagcaagctg accccagcga cacagccccc cagccctact gtatttccgt tcctatcaaa    360

 aaatggatga ctcggagaca ggtttcaatc tgaaagtcgt cctggtcagt ttcaagcagt    420

 gtctcgatga gaaggaagag gtcttgctgg acccctacat tgccagctgg aagggcctgg    480

 tcaggtttct gaacagcctg ggcaccatct tctcattcat ctccaaggac gtggtctcca    540

 agctgcggat catggagcgc ctcaggggcg gcccgcagag cgagcactac cgcagcctgc    600

 aggccatggt ggcccacgag ctgagcaacc ggctggtgga cctggagcgc cgctcccacc    660

 acccggagtc tggctgccgg acggtgctgc gcctgcaccg cgccctgcac tggctgcagc    720

 tgttcctgga gggcctgcgt accagccccg aggacgcacg cacctccgcg ctctgcgccg    780

 actcctacaa cgcctcgctg gccgcctacc acccctgggt cgtgcgccgt gccgtcaccg    840

 tggccttctg cacgctgccc acacgcgagg tcttcctgga ggccatgaac gtggggcccc    900

 cggagcaggc cgtgcagatg ctaggcgagg ccctcccctt catccagcgt gtctacaacg    960

 tctcccagaa gctctacgcc gagcactccc tgctggacct gccctagagg cgggaagcca   1020

 gggccgcacc ggctttcctg ctgcagatct gggctgcggt ggccagggcc gtgagtcccg   1080

 tggcagagcc ttctgggcgc tgcgggaaca ggagatcctc tgtcgcccct gtgagctgag   1140

 ctggttagga accacagact gtgacagaga aggtggcgac cagcccagaa gaggcccacc   1200

 ctctcggtcc ggaacaagac gcctcagcca cggctccccc tcggcctatt acacgcgtgc   1260

 gcagccaggc ctcgccaggg tgcggtgcag agcagagcag gcaggggtgg gggctgggcc   1320

 cgcaagagcc cgaaaggtcg ccacccccta gcctgtgggg tgcatctgcg aaccagggtg   1380

 aagtcacagg tcccggggtg tggaggctcc atcctttctc ctttctgcca gccg  atg    1437
                                                              Met
                                                                1

 tgt cct cat ctc agg ccc gtg cct ggg acc ccg tgt ctg ccc agg tgg     1485
 Cys Pro His Leu Arg Pro Val Pro Gly Thr Pro Cys Leu Pro Arg Trp
               5                  10                  15

 gca gcc ttg agc cca ggg gac tca gtg ccc tcc atg ccc tgg ctg gca     1533
 Ala Ala Leu Ser Pro Gly Asp Ser Val Pro Ser Met Pro Trp Leu Ala
          20                  25                  30

 gaa acc ctc aac agc agt ctg ggc act gtg ggg ctc tcc ccg cct ctc     1581
 Glu Thr Leu Asn Ser Ser Leu Gly Thr Val Gly Leu Ser Pro Pro Leu
      35                  40                  45

 ctg cct tgt ttg ccc ctc agc gtg cca ggc aga ctg ggg gca gga cag     1629
 Leu Pro Cys Leu Pro Leu Ser Val Pro Gly Arg Leu Gly Ala Gly Gln
  50                  55                  60                  65

 ccg gaa gct gag acc aag gct cct cac aga agg gcc cag gaa gtc ccc     1677
 Pro Glu Ala Glu Thr Lys Ala Pro His Arg Arg Ala Gln Glu Val Pro
                  70                  75                  80

 gcc ctt ggg aca gcc tcc tcc gta gcc cct gca cgg cac cag ttc ccc     1725
 Ala Leu Gly Thr Ala Ser Ser Val Ala Pro Ala Arg His Gln Phe Pro
              85                  90                  95

 gag gga cgc agc agg ccg cct ccc gca gcg gcc gtg ggt ctg cac agc     1773
 Glu Gly Arg Ser Arg Pro Pro Pro Ala Ala Ala Val Gly Leu His Ser
         100                 105                 110

 cca gcc cag ccc aag gcc ccc agg agc tgg gac tct gct aca ccc agt     1821
 Pro Ala Gln Pro Lys Ala Pro Arg Ser Trp Asp Ser Ala Thr Pro Ser
     115                 120                 125

 gaa atg ctg tgt ccc ttc tcc ccc gtg ccc ctt gat gcc ccc tcc cca     1869
 Glu Met Leu Cys Pro Phe Ser Pro Val Pro Leu Asp Ala Pro Ser Pro
 130                 135                 140                 145

 cag tgc tca gga gac ccg tgg ggc acg gaa cag gag ggt ctg gac cct     1917
 Gln Cys Ser Gly Asp Pro Trp Gly Thr Glu Gln Glu Gly Leu Asp Pro
                 150                 155                 160

 gtg gcc cag cca aag gct acc aga cag cca caa cca gcc cag cca cca     1965
 Val Ala Gln Pro Lys Ala Thr Arg Gln Pro Gln Pro Ala Gln Pro Pro
             165                 170                 175

 tcc agt gcc tgg ggc ctg gcc act ggc tct tca cag tgg acc cca gca     2013
 Ser Ser Ala Trp Gly Leu Ala Thr Gly Ser Ser Gln Trp Thr Pro Ala
         180                 185                 190

 cct cgg ggt ggc aga ggg acg gcc ccc acg gcc cag cag aca tgc gag     2061
 Pro Arg Gly Gly Arg Gly Thr Ala Pro Thr Ala Gln Gln Thr Cys Glu
     195                 200                 205

 ctt cca gag tgc aat cta tgt gat gtc ttc caa cgt taa taaatcacac      2110
 Leu Pro Glu Cys Asn Leu Cys Asp Val Phe Gln Arg 
 210                 215                 220

 agcctcccag gagggagacg ctggggtgca aaaaacgaaa tcgtcgacag cgaagtcgac   2170

 ccgggaattc cggggcggta cctgc                                         2195




      <210> 288
      <211> 2135
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (278)..(1603)

      <400> 288
 gtaccgctcc ggaattcccg ggtcgacttc gctgtcgacg atttcgttca aaaaccattt     60

 ctccattgca tttatcatct ataaatttgt taagaatgtt aagctattgg agcgcattgg    120

 gatagccaga cctgaagagg agttccatgt tcctttagat tcatatagat gtcaattgtt    180

 tatccagcca gctggaatct tagagcatca gtacaaagaa tctaccactt atatttcctg    240

 gaaggaagaa cttcatagga gcagggaagt cagatgc atg ttg cag tgt cca tca     295
                                          Met Leu Gln Cys Pro Ser
                                            1               5

 gta gaa gtc agc ttc tta cct ctc ata gtg aat aca gtt gct ctg cct      343
 Val Glu Val Ser Phe Leu Pro Leu Ile Val Asn Thr Val Ala Leu Pro
              10                  15                  20

 gat gaa ttg agc tac ata tgt aca cat ggg gaa gac tgg gat gta gct      391
 Asp Glu Leu Ser Tyr Ile Cys Thr His Gly Glu Asp Trp Asp Val Ala
          25                  30                  35

 tac att att cat ctt tat cct tct ctc act ttg cgg aat ctt ctc cca      439
 Tyr Ile Ile His Leu Tyr Pro Ser Leu Thr Leu Arg Asn Leu Leu Pro
      40                  45                  50

 tat tcc cta aga tat tta ctt gag gga aca gca gaa act cat gag ctg      487
 Tyr Ser Leu Arg Tyr Leu Leu Glu Gly Thr Ala Glu Thr His Glu Leu
  55                  60                  65                  70

 gca gaa ggc agt act gct gat gtt ctg cat tcg aga atc agt ggt gaa      535
 Ala Glu Gly Ser Thr Ala Asp Val Leu His Ser Arg Ile Ser Gly Glu
                  75                  80                  85

 ata atg gaa tta gtc ctg gtg aaa tac cag ggc aaa aac tgg aat gga      583
 Ile Met Glu Leu Val Leu Val Lys Tyr Gln Gly Lys Asn Trp Asn Gly
              90                  95                 100

 cat ttc cgc ata cgt gat aca cta cca gaa ttc ttt cct gtg tgt ttt      631
 His Phe Arg Ile Arg Asp Thr Leu Pro Glu Phe Phe Pro Val Cys Phe
         105                 110                 115

 tct tct gac tcc aca gaa gtg acg aca gtc gac ctg tca gtc cac gtc      679
 Ser Ser Asp Ser Thr Glu Val Thr Thr Val Asp Leu Ser Val His Val
     120                 125                 130

 agg aga att ggc agc cgg atg gtg ctg tct gtc ttt agt ccc tat tgg      727
 Arg Arg Ile Gly Ser Arg Met Val Leu Ser Val Phe Ser Pro Tyr Trp
 135                 140                 145                 150

 tta atc aac aag act acc cgg gtt ctc cag tat cgt tca gaa gat att      775
 Leu Ile Asn Lys Thr Thr Arg Val Leu Gln Tyr Arg Ser Glu Asp Ile
                 155                 160                 165

 cat gtg aaa cat cca gct gat ttc agg gat att att tta ttt tct ttc      823
 His Val Lys His Pro Ala Asp Phe Arg Asp Ile Ile Leu Phe Ser Phe
             170                 175                 180

 aag aag aag aac att ttt act aaa aat aag gta caa tta aaa att tca      871
 Lys Lys Lys Asn Ile Phe Thr Lys Asn Lys Val Gln Leu Lys Ile Ser
         185                 190                 195

 acc agt gcc tgg tcc agt agt ttc tca ttg gat aca gtg gga agt tat      919
 Thr Ser Ala Trp Ser Ser Ser Phe Ser Leu Asp Thr Val Gly Ser Tyr
     200                 205                 210

 ggg tgt gtg aag tgt cct gcc aac aat atg gag tac ctg gtt ggt gtt      967
 Gly Cys Val Lys Cys Pro Ala Asn Asn Met Glu Tyr Leu Val Gly Val
 215                 220                 225                 230

 agc atc aaa atg agc agt ttc aac ctt tca cga ata gtt acc ctg act     1015
 Ser Ile Lys Met Ser Ser Phe Asn Leu Ser Arg Ile Val Thr Leu Thr
                 235                 240                 245

 ccc ttt tgt acc att gca aac aag tca tca tta gaa cta gaa gtt ggc     1063
 Pro Phe Cys Thr Ile Ala Asn Lys Ser Ser Leu Glu Leu Glu Val Gly
             250                 255                 260

 gag att gca tct gat ggc tca atg cca act aat aaa tgg aac tat att     1111
 Glu Ile Ala Ser Asp Gly Ser Met Pro Thr Asn Lys Trp Asn Tyr Ile
         265                 270                 275

 gct tct tca gag tgc ctt cca ttt tgg cca gaa aat ttg tca ggc aaa     1159
 Ala Ser Ser Glu Cys Leu Pro Phe Trp Pro Glu Asn Leu Ser Gly Lys
     280                 285                 290

 ctt tgt gtg aga gtg gtg ggc tgt gaa gga tct tcc aaa cca ttc ttt     1207
 Leu Cys Val Arg Val Val Gly Cys Glu Gly Ser Ser Lys Pro Phe Phe
 295                 300                 305                 310

 tat aac cga cag gat aat ggc act tta ttg agc tta gaa gat ctg aat     1255
 Tyr Asn Arg Gln Asp Asn Gly Thr Leu Leu Ser Leu Glu Asp Leu Asn
                 315                 320                 325

 ggg ggt atc ttg gtg gat gta aac act gcc gaa cat tca act gtc ata     1303
 Gly Gly Ile Leu Val Asp Val Asn Thr Ala Glu His Ser Thr Val Ile
             330                 335                 340

 act ttt tct gat tac cat gag gga tct gca cct gcc ttg ata atg aac     1351
 Thr Phe Ser Asp Tyr His Glu Gly Ser Ala Pro Ala Leu Ile Met Asn
         345                 350                 355

 cat aca cca tgg gac atc ctc aca tac aaa cag agt ggg tca cca gaa     1399
 His Thr Pro Trp Asp Ile Leu Thr Tyr Lys Gln Ser Gly Ser Pro Glu
     360                 365                 370

 gaa atg gtc ttg ctg cca aga cag gct cga ctt ttt gcc tgg gca gat     1447
 Glu Met Val Leu Leu Pro Arg Gln Ala Arg Leu Phe Ala Trp Ala Asp
 375                 380                 385                 390

 cct act ggt acc aga aaa ctt aca tgg aca tat gca gca aat gtt ggg     1495
 Pro Thr Gly Thr Arg Lys Leu Thr Trp Thr Tyr Ala Ala Asn Val Gly
                 395                 400                 405

 gaa cat gat ctg tta aag gta tct ttt gat gtg aat gag tgc tat atg     1543
 Glu His Asp Leu Leu Lys Val Ser Phe Asp Val Asn Glu Cys Tyr Met
             410                 415                 420

 agt tac ctg aca gtg aag gaa gta gag aag cta tct tca ctg act cct     1591
 Ser Tyr Leu Thr Val Lys Glu Val Glu Lys Leu Ser Ser Leu Thr Pro
         425                 430                 435

 tgt cct aat tga act aaaagtgaat tggaagtatt tccagaataa gtagcttttg     1646
 Cys Pro Asn 
     440

 gactttagat ggcaaatacc tgtagttcaa accagtatat taccttagct ctatcaaagt   1706

 catttattta caatttaaca aatagacctg ctttatcttg cctatgtaaa gcaccttttt   1766

 aattaattta cctattttaa aaggaaggaa ttgtaagact aagttaaaaa caactttatt   1826

 ttgaacatac ctatgccact tttggctatg agtttttaaa gcttgttttc ctaagcacag   1886

 ctatgtattt tgttaattaa tgaagtctga tagtatgcaa attatcgcat gtaagaaatt   1946

 tagtgaaata tttatcgaaa caatatttag gtagctgagt tgattaaata tgttattttt   2006

 tagactctta gcctctgaaa gggcccaaag aattcatata ccatcctccc atctgatata   2066

 ggaattgctc ctgcattagt aatatatcat ccagtttctg tatgaataaa atccatgatg   2126

 aaagagttt                                                           2135




      <210> 289
      <211> 2633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (291)..(1685)

      <400> 289
 ggactcggcc gacgcgagcg ccgcgcttcg cttcagctgc tagctggccc aagggaggcg     60

 accgcggagg gtggcgaggg gcggccagga cccgcagccc cggggccggg ccggtccgga    120

 ccgccaggga gggcaggtca gtgggcagat cgcgtccgcg ggattcaatc tctgcccgct    180

 ctgataacag tccttttccc tggcgctcac ttcgtgcctg gcacccggct gggcgcctca    240

 agaccgttgt ctcttcgatc gcttctttgg acttggcgac catttcagag   atg tct     296
                                                          Met Ser
                                                            1

 tcc aga agt acc aaa gat tta att aaa agt aag tgg gga tcg aag cct      344
 Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser Lys Pro
           5                  10                  15

 agt aac tcc aaa tcc gaa act aca tta gaa aaa tta aag gga gaa att      392
 Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly Glu Ile
      20                  25                  30

 gca cac tta aag aca tca gtg gat gaa atc aca agt ggg aaa gga aag      440
 Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys Gly Lys
  35                  40                  45                  50

 ctg act gat aaa gag aga cac aga ctt ttg gag aaa att cga gtc ctt      488
 Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg Val Leu
                  55                  60                  65

 gag gct gag aag gag aag aat gct tat caa ctc aca gag aag gac aaa      536
 Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys Asp Lys
              70                  75                  80

 gaa ata cag cga ctg aga gac caa ctg aag gcc aga tat agt act acc      584
 Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser Thr Thr
          85                  90                  95

 gca ttg ctt gaa cag ctg gaa gag aca acg aga gaa gga gaa agg agg      632
 Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu Arg Arg
     100                 105                 110

 gag cag gtg ttg aaa gcc tta tct gaa gag aaa gac gta ttg aaa caa      680
 Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu Lys Gln
 115                 120                 125                 130

 cag ttg tct gct gca acc tca cga att gct gaa ctt gaa agc aaa acc      728
 Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser Lys Thr
                 135                 140                 145

 aat aca ctc cgt tta tca cag act gtg gct cca aac tgc ttc aac tca      776
 Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe Asn Ser
             150                 155                 160

 tca ata aat aat att cat gaa atg gaa ata cag ctg aaa gat gct ctg      824
 Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp Ala Leu
         165                 170                 175

 gag aaa aat cag cag tgg ctc gtg tat gat cag cag cgg gaa gtc tat      872
 Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu Val Tyr
     180                 185                 190

 gta aaa gga ctt tta gca aag atc ttt gag ttg gaa aag aaa acg gaa      920
 Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys Thr Glu
 195                 200                 205                 210

 aca gct gct cat tca ctc cca cag cag aca aaa aag cct gaa tca gaa      968
 Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu Ser Glu
                 215                 220                 225

 ggt tat ctt caa gaa gag aag cag aaa tgt tac aac gat ctc ttg gca     1016
 Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu Leu Ala
             230                 235                 240

 agt gca aaa aaa gat ctt gag gtt gaa cga caa acc ata act cag ctg     1064
 Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr Gln Leu
         245                 250                 255

 agt ttt gaa ctg agt gaa ttt cga aga aaa tat gaa gaa acc caa aaa     1112
 Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr Gln Lys
     260                 265                 270

 gaa gtt cac aat tta aat cag ctg ttg tat tca caa aga agg gca gat     1160
 Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg Ala Asp
 275                 280                 285                 290

 gtg caa cat ctg gaa gat gat agg cat aaa aca gag aag ata caa aaa     1208
 Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile Gln Lys
                 295                 300                 305

 ctc agg gaa gag aat gat att gct agg gga aaa ctt gaa gaa gag aag     1256
 Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu Glu Lys
             310                 315                 320

 aag aga tcc gaa gag ctc tta tct cag gtc cag ttt ctt tac aca tct     1304
 Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr Thr Ser
         325                 330                 335

 ctg cta aag cag caa gaa gaa caa aca agg gta gct ctg ttg gaa caa     1352
 Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu Glu Gln
     340                 345                 350

 cag atg cag gca tgt act tta gac ttt gaa aat gaa aaa ctc gac cgt     1400
 Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu Asp Arg
 355                 360                 365                 370

 caa cat gtg cag cat caa ttg cat gta att ctt aag gag ctc cga aaa     1448
 Gln His Val Gln His Gln Leu His Val Ile Leu Lys Glu Leu Arg Lys
                 375                 380                 385

 gca aga aat caa ata aca cag ttg gaa tcc ttg aaa cag ctt cat gag     1496
 Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu His Glu
             390                 395                 400

 ttt gcc atc aca gag cca tta gtc act ttc caa gga gag act gaa aac     1544
 Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr Glu Asn
         405                 410                 415

 aga gaa aaa gtt gcc gcc tca cca aaa agt ccc act gct gca ctc aat     1592
 Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala Leu Asn
     420                 425                 430

 gaa agc ctg gtg gaa tgt ccc aag tgc aat ata cag tat cca gcc act     1640
 Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro Ala Thr
 435                 440                 445                 450

 gag cat cgc gat ctg ctt gtc cat gtg gaa tac tgt tca aag tag caa     1688
 Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys 
                 455                 460

 aataagtatt tgttttgata ttaaaagatt caatactgta ttttctgtta gcttgtgggc   1748

 attttgaatt atatatttca cattttgcat aaaactgcct atctaccttt gacactccag   1808

 catgctagtg aatcatgtat cttttaggct gctgtgcatt tctcttggca gtgatacctc   1868

 cctgacatgg ttcatcatca ggctgcaatg acagaatgtg gtgagcagcg tctactgaga   1928

 ctactaacat tttgcactgt caaaatactt ggtgaggaaa agatagctca ggttattgct   1988

 aatgggttaa tgcaccagca agcaaaatat tttatgtttt gggggtttga aaaatcaaag   2048

 ataattaacc aaggatctta actgtgttcg cattttttat ccaagcactt agaaaaccta   2108

 caatcctaat tttgatgtcc attgttaaga ggtggtgata gatactattt tttttttcat   2168

 attgtatagc ggttattaga aaagttgggg attttcttga tctttattgc tgcttaccat   2228

 tgaaacttaa cccagctgtg ttccccaact ctgttctgcg cacgaaacag tatctgtttg   2288

 aggcataatc ttaagtggcc acacacaatg ttttctctta tgttatctgg cagtaactgt   2348

 aacttgaatt acattagcac attctgctta gctaaaattg ttaaaataaa ctttaataaa   2408

 cccatgtagc cctctcattt gattgacagt attttagtta tttttggcat tcttaaagct   2468

 gggcaatgta atgatcagat ctttgtttgt ctgaacaggt atttttatac atgctttttg   2528

 taaaccaaaa acttttaaat ttcttcaggt tttctaacat gcttaccact gggctactgt   2588

 aaatgagaaa agaataaaat tatttaatgt tttaaaaaaa aaaaa                   2633




      <210> 290
      <211> 2953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (207)..(1124)

      <400> 290
 acagaaggcg atgggccgag agctgaggaa ctacaactcc tagagtactc cgcgccgccg     60

 ggacgccgcg cggctgcggg gctgggcgag cgcaaagatg tccgcgcccg ctgccgggag    120

 gcgaggccaa ctcgggatat cccggagcct ctggggaggc ggtcactccg acgtctgagg    180

 acctgggcct tggacccgga ctcgtt atg aag agc gat tct tcg acc tct gca     233
                              Met Lys Ser Asp Ser Ser Thr Ser Ala
                                1               5

 gcc ccc ctc agg ggg ctc ggg gga ccc ctg cgc agc agc gag ccg gtg      281
 Ala Pro Leu Arg Gly Leu Gly Gly Pro Leu Arg Ser Ser Glu Pro Val
  10                  15                  20                  25

 cgc gcg gtc ccg gcc cgg gcg ccg gcc gtg gac ctt ctg gag gag gcg      329
 Arg Ala Val Pro Ala Arg Ala Pro Ala Val Asp Leu Leu Glu Glu Ala
                  30                  35                  40

 gcc gac ctc ctg gtg gtg cac ctg gac ttc cgg gcg gcg ctg gag acc      377
 Ala Asp Leu Leu Val Val His Leu Asp Phe Arg Ala Ala Leu Glu Thr
              45                  50                  55

 tgc gag cgg gcc tgg cag agt ctg gcc aac cac gcc gtg gca gag gaa      425
 Cys Glu Arg Ala Trp Gln Ser Leu Ala Asn His Ala Val Ala Glu Glu
          60                  65                  70

 ccc gcg ggc acc tca ttg gag gtg aag tgc tcc ctg tgt gtt gtg ggg      473
 Pro Ala Gly Thr Ser Leu Glu Val Lys Cys Ser Leu Cys Val Val Gly
      75                  80                  85

 atc cag gcc ctg gca gaa atg gat cgg tgg caa gaa gtc ctc tcc tgg      521
 Ile Gln Ala Leu Ala Glu Met Asp Arg Trp Gln Glu Val Leu Ser Trp
  90                  95                 100                 105

 gtc ctt cag tat tac cag gtc cct gaa aag cta ccc ccc aaa gtc ctg      569
 Val Leu Gln Tyr Tyr Gln Val Pro Glu Lys Leu Pro Pro Lys Val Leu
                 110                 115                 120

 gag ctg tgc att ctt tta tac agc aaa atg caa gag cct gga gct gtg      617
 Glu Leu Cys Ile Leu Leu Tyr Ser Lys Met Gln Glu Pro Gly Ala Val
             125                 130                 135

 ctg gat gtg gtg ggt gcc tgg ctc caa gac cca gcc aat caa aac ctt      665
 Leu Asp Val Val Gly Ala Trp Leu Gln Asp Pro Ala Asn Gln Asn Leu
         140                 145                 150

 cca gaa tat gga gcc ttg gca gaa ttt cac gtg cag cgg gtg ctg ctg      713
 Pro Glu Tyr Gly Ala Leu Ala Glu Phe His Val Gln Arg Val Leu Leu
     155                 160                 165

 cct ctg ggc tgc tta tcg gag gct gag gag cta gtg gtg ggc tct gca      761
 Pro Leu Gly Cys Leu Ser Glu Ala Glu Glu Leu Val Val Gly Ser Ala
 170                 175                 180                 185

 gcc ttt ggt gag gag cgg cga ctg gat gta ctt cag gcc att cac aca      809
 Ala Phe Gly Glu Glu Arg Arg Leu Asp Val Leu Gln Ala Ile His Thr
                 190                 195                 200

 gcg agg cag cag cag aaa cag gaa cac tca ggc tct gag gag gcc cag      857
 Ala Arg Gln Gln Gln Lys Gln Glu His Ser Gly Ser Glu Glu Ala Gln
             205                 210                 215

 aag cca aac ctg gaa ggc tct gtc tcc cac aag ttc ctg tca cta ccg      905
 Lys Pro Asn Leu Glu Gly Ser Val Ser His Lys Phe Leu Ser Leu Pro
         220                 225                 230

 atg ttg gtt cgc cag ctt tgg gac tct gcg gtg agc cac ttc ttt tct      953
 Met Leu Val Arg Gln Leu Trp Asp Ser Ala Val Ser His Phe Phe Ser
     235                 240                 245

 ctg ccc ttc aaa aag agt ctc ctg gct gcc ttg atc ctc tgt ctc ctg     1001
 Leu Pro Phe Lys Lys Ser Leu Leu Ala Ala Leu Ile Leu Cys Leu Leu
 250                 255                 260                 265

 gtg gtg aga ttt gat cca gct tcc cct tcc tcc ctg cac ttc ctc tac     1049
 Val Val Arg Phe Asp Pro Ala Ser Pro Ser Ser Leu His Phe Leu Tyr
                 270                 275                 280

 aag ctg gcc cag ctc ttc cgc tgg atc cgg aag gct gca ttt tct cgc     1097
 Lys Leu Ala Gln Leu Phe Arg Trp Ile Arg Lys Ala Ala Phe Ser Arg
             285                 290                 295

 ctc tac cag ctc cgc atc cgt gac tga gggtc cctgcgcacc acagcctctc     1149
 Leu Tyr Gln Leu Arg Ile Arg Asp 
         300                 305

 tgctcctcac gtccgtggcc acagaagcag agcgacagag cgacacatcc acaggcgccc   1209

 ctggggaaat gggaccagcc taatctcgcg gagtgcactg tgtcttgctg cctgggtgcc   1269

 ctctcctttg caccctactt cagctggtcg cggtagatga tgtggaaaca aagcaggacc   1329

 agcaggcaca gcacctccag aacagtgccc cggatgacca gaggcccctt gaaaaggagg   1389

 ggtttgggga cagggactgt gtccatgaaa cattccatct tcttggtgaa ggcaaggggt   1449

 tggttcttca ggtcaggatg ttaatggagc tggaagttca gaaaaagcct ggtgaagtga   1509

 cccttggcct ttcacttctt gagaaacata cttctttgct gggcatggtg gctcacgcct   1569

 gtggtcccag cactttggca ggtgtgagcc atcgcgcccg gccaactttt ctttagaaaa   1629

 atgagtaaag taggtaaact tcacaggccc cttagaatta aatccttagg gcatggttca   1689

 agtctgtagg aagcaaatct atactttttt atatgggctt ttaagtagag cttagaaccc   1749

 tggggggaga aaagcagtca ggtgaggttt gagattcctt ctatagaatg atttcttaaa   1809

 atgaaaatct gggcccactt aactacccta gataaaacgt ttcaatggct tcccatggct   1869

 cactggataa catctaaatt cttcatggaa ttgaaggccc ctatgtgctg gttttggcta   1929

 agatctcccc tttgatgtgg gtcccctgtt gattatacgt gcggccttcc agctgcccac   1989

 catcacagct acagctcgct ccccttggcc tctgtgcctt ggctcgcact gttcctactg   2049

 aaggcctagc acctgctctt ggcctggtga gcccctccac cttccaggct tactcaaaga   2109

 attctttctg cccctccctg tgtcccggga cctgtttcat atcgcttctg tggtcgtgac   2169

 cccatggtct tgtaattgtg aacttctttg ctgccccttc gaagctgggg agtgcttgtt   2229

 gcagatgcat ccaagagggg taattgcgta tcaacagtgg atttgctggt tgtttctaca   2289

 gggttctgaa gcatgcaaca tagaacagat acctttaaat ttaggggcgc taaggaaagc   2349

 aggaaccagt aatcctcttc tgtggtggga tgggagggtg ggggagaggg gtggaatgga   2409

 gaggaaacag gctattgttg gccagccctg ggtggaggtg ggtgcaagca ggacagatag   2469

 tgcctggggg tgggggcgga gggttcgcct ctaggaaggg gctagaaggg atgaggaaat   2529

 agttcatagc ttcgtgcagg tgatccctat tctgcgtgta tgtgtttgca catgagtgtt   2589

 tgtagaccat agaccattaa aaaatacgga attcaaaagt tacaaaaagg gtattcttgg   2649

 aaaagaaagt tgtttttttt tagtcttgct gtgttgccca ggctggacct gaactcctgg   2709

 gcttgagcaa gtcttcccct cagcctctgg agtagctggg cctacagtgt gtgctgccac   2769

 acccagctaa tacagtcttt ctactcccgc tctctattcc ccagtttctt gcccagaggc   2829

 aacccttgcc agtctgttta tccctccaga tacagtctct gatagtaaac ttttctttct   2889

 cttacacaaa tgatagtagt cacatacact acacacactg tgccacgttt aaaaaaaaaa   2949

 aaaa                                                                2953




      <210> 291
      <211> 1364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (216)..(509)

      <400> 291
 ggaaattagc atgggtttaa aacttggctc ttttgtatcc gtttttgaca acattaaaaa     60

 atagctacag aaaaatactt acatagtcag ggctacagaa aaaaatacat atttaggata    120

 cgatgaaaac cgcagcatgc ttcactggat ttttctcttg gtctactctt aagattcatc    180

 aaggaaatat aagcataata taattcttgt tcaaa   atg ccc agc aca gtg att     233
                                          Met Pro Ser Thr Val Ile
                                            1               5

 gta atg tgt cag ttg aaa gcc atc ttt cta ggt tca gct cat gta agc      281
 Val Met Cys Gln Leu Lys Ala Ile Phe Leu Gly Ser Ala His Val Ser
              10                  15                  20

 ctc tct gaa tgt cac aag tgt ata ttg ttc tat att tat ctt aaa act      329
 Leu Ser Glu Cys His Lys Cys Ile Leu Phe Tyr Ile Tyr Leu Lys Thr
          25                  30                  35

 gct aag aag tta ggg gaa atg gaa atg cct gca cag ata gtc aaa ata      377
 Ala Lys Lys Leu Gly Glu Met Glu Met Pro Ala Gln Ile Val Lys Ile
      40                  45                  50

 gaa atg gac acg gac caa aaa tgc tgg tgg ctt tac aag gga tgc ttt      425
 Glu Met Asp Thr Asp Gln Lys Cys Trp Trp Leu Tyr Lys Gly Cys Phe
  55                  60                  65                  70

 ctc aaa aat tta aaa cgt ggg gag gga aga aca tgg tta gga aaa cag      473
 Leu Lys Asn Leu Lys Arg Gly Glu Gly Arg Thr Trp Leu Gly Lys Gln
                  75                  80                  85

 atg act gtc tat tcc aca tca ctc tgc ggc ctt taa aata ggcttttaaa      523
 Met Thr Val Tyr Ser Thr Ser Leu Cys Gly Leu 
              90                  95

 atttttccag ccttgggaac ttggataaaa aggggcagat aaagcagaaa caactctcag    583

 cttgttgctg ccattgctca ccactaggtg gcgacagagt gcagctgcat tacaaatctc    643

 tgcttaagcg acttgccatt tgagttacat caccaagggg aaagggcgaa agacagtctc    703

 cccagataat ctatttacat caccttatag gacatttgca cctacctcag cgtcaaaatt    763

 aagatgctga ttttagccaa ggtaggccaa gtagtccatc atagtaatct ttcatgcaat    823

 agcgtgcaca tcgaaattac cattttgttt ctttttctgt ttgtttttta cctatttgtc    883

 gtattaagaa attatccagt atctttgggt tttggtttac cattctgcaa aatggagttg    943

 aattgtaacc attatttttt tttacgtgac cgagacacat gagaattaac caatcaatgt   1003

 cagtgtccca gctctctgtg taaaactgat gacggacacc tttacacagc agaggaaata   1063

 catctgtgga aatgtgtatc cttcatggaa tccctgaggg gacccgatta accctcatct   1123

 tgtccaactc attgatttca gagataggga agctgaggca tccccaaggt tatatggtgc   1183

 ttaacgccca aaacagaaag acgcagatga gccgtcttag ataactggtc ttgctactca   1243

 ttccctacta gtcaaatgcc tttaaaataa actatttcaa gtactgtaat tagtcagctt   1303

 tcctcaaaac tgtctcctag ttatccacat taacatggag gtgattcttg ttaaaggtaa   1363

 g                                                                   1364




      <210> 292
      <211> 766
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(587)

      <400> 292
 tcccgggtcg acgatttcgt gcgaggttat cgttaggcat ctcccaggcg accgggtccg     60

 cagctagatg gcggacgaga aggacaggga agggcctggg atacaacagt gatgagataa    120

 ggcctcggac tttactgatc gaacatcta  atg gaa ggt gga aga aga gac cat     173
                                  Met Glu Gly Gly Arg Arg Asp His
                                    1               5

 cac aca atg acg gtg tta tgg gga aca cag gag ata ata gta gca gaa      221
 His Thr Met Thr Val Leu Trp Gly Thr Gln Glu Ile Ile Val Ala Glu
      10                  15                  20

 ttt cac aaa aaa atc aaa gag gca ttt gaa gtc ttt gac cat gag tcg      269
 Phe His Lys Lys Ile Lys Glu Ala Phe Glu Val Phe Asp His Glu Ser
  25                  30                  35                  40

 aat aat aca gtg gat gtg aga gag att gga aca att atc agg tca tta      317
 Asn Asn Thr Val Asp Val Arg Glu Ile Gly Thr Ile Ile Arg Ser Leu
                  45                  50                  55

 gga tgc tgt cct acg gaa gga gag ctg cat gat ctg att gca gag gta      365
 Gly Cys Cys Pro Thr Glu Gly Glu Leu His Asp Leu Ile Ala Glu Val
              60                  65                  70

 gag gaa gaa gaa cct act gga tac att cga ttc gaa aaa ttt ctt ccg      413
 Glu Glu Glu Glu Pro Thr Gly Tyr Ile Arg Phe Glu Lys Phe Leu Pro
          75                  80                  85

 gtg atg aca gaa ata cta cta gaa aga aaa tac aga cca att cca gaa      461
 Val Met Thr Glu Ile Leu Leu Glu Arg Lys Tyr Arg Pro Ile Pro Glu
      90                  95                 100

 gat gtc ctt ctt cga gct ttt gag gtt tta gat tca gct aaa cgt ggg      509
 Asp Val Leu Leu Arg Ala Phe Glu Val Leu Asp Ser Ala Lys Arg Gly
 105                 110                 115                 120

 ttt ctt act aag gac gag ctg atc aag tat atg act gaa gaa gag aca      557
 Phe Leu Thr Lys Asp Glu Leu Ile Lys Tyr Met Thr Glu Glu Glu Thr
                 125                 130                 135

 ggt aag cta agg tgg gga gct gtg aag tga c ttgctcaaga tctcagagct      608
 Gly Lys Leu Arg Trp Gly Ala Val Lys 
             140                 145

 cgtgagaggc agccagcatg tggatccaaa cttgtgcttt aaccactcag ttatcttcct    668

 tccatctttc atcaaatact ggggcttcaa gttaatcctc tggtaatttc aaaagtttta    728

 atctaaataa ataaccttgt tcatgaaaaa aaaaaaaa                            766




      <210> 293
      <211> 1021
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(614)

      <400> 293
 tcccgggtcg acgatttcgt gcgaggttat cgttaggcat ctcccaggcg accgggtccg     60

 cagctagatg gcggacgaga aggacaggga agggcctggg atacaacagt gatgagataa    120

 ggcctcggac tttactgatc gaacatcta  atg gaa ggt gga aga aga gac cat     173
                                  Met Glu Gly Gly Arg Arg Asp His
                                    1               5

 cac aca atg acg gtg tta tgg gga aca cag gag ata ata gta gca gaa      221
 His Thr Met Thr Val Leu Trp Gly Thr Gln Glu Ile Ile Val Ala Glu
      10                  15                  20

 ttt cac aaa aaa atc aaa gag gca ttt gaa gtc ttt gac cat gag tcg      269
 Phe His Lys Lys Ile Lys Glu Ala Phe Glu Val Phe Asp His Glu Ser
  25                  30                  35                  40

 aat aat aca gtg gat gtg aga gag att gga aca att atc agg tca tta      317
 Asn Asn Thr Val Asp Val Arg Glu Ile Gly Thr Ile Ile Arg Ser Leu
                  45                  50                  55

 gga tgc tgt cct acg gaa gga gag ctg cat gat ctg att gca gag gta      365
 Gly Cys Cys Pro Thr Glu Gly Glu Leu His Asp Leu Ile Ala Glu Val
              60                  65                  70

 gag gaa gaa gaa cct act gga tac att cga ttc gaa aaa ttt ctt ccg      413
 Glu Glu Glu Glu Pro Thr Gly Tyr Ile Arg Phe Glu Lys Phe Leu Pro
          75                  80                  85

 gtg atg aca gaa ata cta cta gaa aga aaa tac aga cca att cca gaa      461
 Val Met Thr Glu Ile Leu Leu Glu Arg Lys Tyr Arg Pro Ile Pro Glu
      90                  95                 100

 gat gtc ctt ctt cga gct ttt gag gtt tta gat tca gct aaa cgt ggg      509
 Asp Val Leu Leu Arg Ala Phe Glu Val Leu Asp Ser Ala Lys Arg Gly
 105                 110                 115                 120

 ttt ctt act aag gac gag ctg atc aag tat atg act gaa gaa ggt ggt      557
 Phe Leu Thr Lys Asp Glu Leu Ile Lys Tyr Met Thr Glu Glu Gly Gly
                 125                 130                 135

 gtc gtt atc acc ccc att cta gag aca ggt aag cta agg tgg gga gct      605
 Val Val Ile Thr Pro Ile Leu Glu Thr Gly Lys Leu Arg Trp Gly Ala
             140                 145                 150

 gtg aag tga cttgctc aagatctcag agctcgtgag aggcagccag catgtggatc      661
 Val Lys 


 caaacttgtg ctttaaccac tcagttatct tccttccatc tttcatcaaa tactggggct    721

 tcaagttaat cctctggtaa tttcaaaagt tttaatctaa ataaataacc ttgttcatga    781

 tgtctgtatg tcttcctact gttttgcctg aaatgacgtg ttctagaggt tgcttgatct    841

 atgacatctg caggctaaaa gaagtccaga atctaccagg gtgtacaata gccttgtctt    901

 tgaacctctg gactgtcgtg atgtcctggc tctacagctc cagggagcgt aactagtggc    961

 actgtgggag cttgtggggc tccatggcta ttaagctggc tagtggaaag aaaaaaaaaa   1021




      <210> 294
      <211> 4633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1436)..(4216)

      <400> 294
 gcagcgtagc gggctggcgg tgacttacac cgggactcca gagggagaga ggaagcgctg     60

 caggccactt gcattgcgtc ttccaggctg cgtggacccg gcgccccggc gtgtgcggtt    120

 gtgggggagc tcgccgtggc ctcccctccc tctggcttta gcttcctttg gggttggcgc    180

 aggtgggcca ggcagcgcac cgcagatctc cccgttccca cgaaggctgg ctcgctgtct    240

 ctctccgagc gggagggacc atcctaaaaa tatgtaaata tccaagcgct ggctccaggc    300

 tggggcagct gccaaggtcc ccgcgccgcc gccgggtgtt ttacatgaaa atgagaagcc    360

 tgatgggaac cgcgttctaa cttaaggcag cctggtgatt agcatgagac tgggcggctg    420

 tcctgcttcc tgcccttcaa tagccgttcc gcgcgctcgc gccggagcag cgctgccgcc    480

 gcgcgggggt cgatcgcagg ctcggcgtcc ttggcagcca tggctccggc gccgcctcgg    540

 ccagtaagta ggagcatgca tgtgtagggg gcacatgcgt gtcggcgcac ccacccagcc    600

 atccacccgc gcgcacgcac agcgcccgga gcctcggcaa ggggaagatt gacgaggcgc    660

 tgcagtcgcg gggacgacgc gggctcttcc tggattccgc aggagcccgc ccgccgcagc    720

 tgctgtctgc agagcctgct cggatcctgt gcacacgcgc cccccgctcg agcctctgtg    780

 atgaagactg tctcccgggg actgcagcgg aggcagagcc agccagcgcc ggggactgcg    840

 ggccgtgcgg ctgataggcc cgcggggaca cgactcggac actgtcatcc ccacgcctcg    900

 cgctgagctg cccggcgcgg agggtctgcc gccgcccctc cggcctcccg cacgcccgat    960

 cccgggtcag ccccggaggc ctcggctgcc tcatttgttt gggtcttttg tgccgtggct   1020

 cccagttggc caagcactcc tgcgctgaat cgggccattg tctgcgctcc cattgccttc   1080

 acgctgcaag tctcggcgcc cccaccccgc ccgccccctc cccgcctcct cccggccggg   1140

 gagcctccta acgtgccttt ccccccagga atctggaagc tataagccgg gcggattgca   1200

 aatgaagtgt aatgcattgt gggacgtgtg taaaatcgga gccttcgccg tgggggtgtg   1260

 ggggggcgtg gggagggccg gacccgccgc tggcggtgta gacgccgacg aggaggggct   1320

 gggaaaatgt gcgcagagtc cgcccgggtc gtgcccgccg tagacggatg aaggagcgcg   1380

 ctgcgccccg gcgctgaggc cccgaggatc ggggcggcag gtcgccctcc ccacc atg    1438
                                                              Met
                                                                1

 aag aag acc cgg agc aca acc ttg cgg cga gcc tgg cct agc tcg gat     1486
 Lys Lys Thr Arg Ser Thr Thr Leu Arg Arg Ala Trp Pro Ser Ser Asp
               5                  10                  15

 ttc tcg gac cgg gcc tcg gac cgc atg agg tcc cgc agc gag aag gac     1534
 Phe Ser Asp Arg Ala Ser Asp Arg Met Arg Ser Arg Ser Glu Lys Asp
          20                  25                  30

 tac cgc ctg cac aag cgt ttc ccc gcg gcc ttc gcg ccc cag gct tcg     1582
 Tyr Arg Leu His Lys Arg Phe Pro Ala Ala Phe Ala Pro Gln Ala Ser
      35                  40                  45

 cgg ggc tac atg aca tca ggt gat gta tca ccc atc agt atg tct ccc     1630
 Arg Gly Tyr Met Thr Ser Gly Asp Val Ser Pro Ile Ser Met Ser Pro
  50                  55                  60                  65

 atc agt cag tct cag ttt att cca ctc ggg gag atc ctc tgc ttg gcc     1678
 Ile Ser Gln Ser Gln Phe Ile Pro Leu Gly Glu Ile Leu Cys Leu Ala
                  70                  75                  80

 atc tca gca atg aac tcg gca aga aag cct gtc acc caa gaa gca ctg     1726
 Ile Ser Ala Met Asn Ser Ala Arg Lys Pro Val Thr Gln Glu Ala Leu
              85                  90                  95

 atg gag cac ctg acc acg tgc ttc cca ggt gtt cca acg cca agc caa     1774
 Met Glu His Leu Thr Thr Cys Phe Pro Gly Val Pro Thr Pro Ser Gln
         100                 105                 110

 gaa att ctg cgg cac acg ctg aac acg ctg gta cgg gag agg aag atc     1822
 Glu Ile Leu Arg His Thr Leu Asn Thr Leu Val Arg Glu Arg Lys Ile
     115                 120                 125

 tac cca act cca gat ggc tac ttc atc gtg acc cca cag act tat ttc     1870
 Tyr Pro Thr Pro Asp Gly Tyr Phe Ile Val Thr Pro Gln Thr Tyr Phe
 130                 135                 140                 145

 ata act cct tcc ctc ata aga act aac agt aaa tgg tac cat ttg gac     1918
 Ile Thr Pro Ser Leu Ile Arg Thr Asn Ser Lys Trp Tyr His Leu Asp
                 150                 155                 160

 gag agg ata cct gac cgg tct cag tgc acc tct ccg caa ccc ggg acc     1966
 Glu Arg Ile Pro Asp Arg Ser Gln Cys Thr Ser Pro Gln Pro Gly Thr
             165                 170                 175

 atc acg ccc tct gcc tca ggc tgt gtc agg gaa agg aca ttg ccc cga     2014
 Ile Thr Pro Ser Ala Ser Gly Cys Val Arg Glu Arg Thr Leu Pro Arg
         180                 185                 190

 aac cac tgc gac tct tgc cac tgc tgc aga gaa gac gtg cac agc acg     2062
 Asn His Cys Asp Ser Cys His Cys Cys Arg Glu Asp Val His Ser Thr
     195                 200                 205

 cat gca ccc acc ctg caa agg aag tct gcc aag gac tgc aaa gac cct     2110
 His Ala Pro Thr Leu Gln Arg Lys Ser Ala Lys Asp Cys Lys Asp Pro
 210                 215                 220                 225

 tac tgt ccc cct tct ctg tgc cag gtg cca ccc act gaa aag agc aaa     2158
 Tyr Cys Pro Pro Ser Leu Cys Gln Val Pro Pro Thr Glu Lys Ser Lys
                 230                 235                 240

 agt act gta aat ttt tcc tat aag aca gaa act ctc tca aaa cct aaa     2206
 Ser Thr Val Asn Phe Ser Tyr Lys Thr Glu Thr Leu Ser Lys Pro Lys
             245                 250                 255

 gat agt gaa aag cag tca aaa aaa ttc ggg cta aag tta ttc cgg tta     2254
 Asp Ser Glu Lys Gln Ser Lys Lys Phe Gly Leu Lys Leu Phe Arg Leu
         260                 265                 270

 agt ttt aaa aaa gac aag acc aaa cag ctg gcc aat ttt tct gcc cag     2302
 Ser Phe Lys Lys Asp Lys Thr Lys Gln Leu Ala Asn Phe Ser Ala Gln
     275                 280                 285

 ttt cct cct gaa gag tgg ccc ctg cga gac gag gac acg cca gct acg     2350
 Phe Pro Pro Glu Glu Trp Pro Leu Arg Asp Glu Asp Thr Pro Ala Thr
 290                 295                 300                 305

 atc cct cgg gaa gta gag atg gaa atc att agg cgc att aac cca gac     2398
 Ile Pro Arg Glu Val Glu Met Glu Ile Ile Arg Arg Ile Asn Pro Asp
                 310                 315                 320

 ctg acc gtg gaa aat gtc atg cgg cac acc gcg ctc atg aag aaa ctg     2446
 Leu Thr Val Glu Asn Val Met Arg His Thr Ala Leu Met Lys Lys Leu
             325                 330                 335

 gaa gaa gaa aag gcc cag agg agt aaa gcc ggg tcc tct gcc cat cac     2494
 Glu Glu Glu Lys Ala Gln Arg Ser Lys Ala Gly Ser Ser Ala His His
         340                 345                 350

 agc gga agg agt aaa aag agt agg act cat cgg aag tcc cat gga aag     2542
 Ser Gly Arg Ser Lys Lys Ser Arg Thr His Arg Lys Ser His Gly Lys
     355                 360                 365

 tct cgg tct cac agc aag aca cgg gtg tct aaa gga gac cct tcc gac     2590
 Ser Arg Ser His Ser Lys Thr Arg Val Ser Lys Gly Asp Pro Ser Asp
 370                 375                 380                 385

 ggt tca cat ctg gat atc cca gct gaa aga gag tat gac ttt tgt gat     2638
 Gly Ser His Leu Asp Ile Pro Ala Glu Arg Glu Tyr Asp Phe Cys Asp
                 390                 395                 400

 cct ctt acc agg gtg ccc agg gag ggc tgc ttc atc att gaa cac aaa     2686
 Pro Leu Thr Arg Val Pro Arg Glu Gly Cys Phe Ile Ile Glu His Lys
             405                 410                 415

 gga gat aac ttc atc atg cac agc aac aca aac gtg ctc gag tcc cac     2734
 Gly Asp Asn Phe Ile Met His Ser Asn Thr Asn Val Leu Glu Ser His
         420                 425                 430

 ttc ccc atg aca cca gaa tgg gat gtg tct ggt gaa ttg gct aaa agg     2782
 Phe Pro Met Thr Pro Glu Trp Asp Val Ser Gly Glu Leu Ala Lys Arg
     435                 440                 445

 aga act gag atg cct ttt cct gaa cct tct agg gga agc tcc cac tca     2830
 Arg Thr Glu Met Pro Phe Pro Glu Pro Ser Arg Gly Ser Ser His Ser
 450                 455                 460                 465

 aaa gtg cac cga agc cac agc cat aca cag gac cgg agg tcc agg aat     2878
 Lys Val His Arg Ser His Ser His Thr Gln Asp Arg Arg Ser Arg Asn
                 470                 475                 480

 gag aga tcc aac aaa gcc aag gag aga tcc agg tcg atg gat aac tcc     2926
 Glu Arg Ser Asn Lys Ala Lys Glu Arg Ser Arg Ser Met Asp Asn Ser
             485                 490                 495

 aaa ggc cct ctg ggt gct tct tct cta ggg acg ccg gaa gac ctt gct     2974
 Lys Gly Pro Leu Gly Ala Ser Ser Leu Gly Thr Pro Glu Asp Leu Ala
         500                 505                 510

 gaa ggc tgc agc caa gac gac cag acc ccc agc caa tcc tac att gac     3022
 Glu Gly Cys Ser Gln Asp Asp Gln Thr Pro Ser Gln Ser Tyr Ile Asp
     515                 520                 525

 gac agt act tta agg cct gca cag acc gtt agt ctc caa agg gct cac     3070
 Asp Ser Thr Leu Arg Pro Ala Gln Thr Val Ser Leu Gln Arg Ala His
 530                 535                 540                 545

 att tcg tcc aca agc tat aaa gag gtg tgt att cca gag ata gtc agt     3118
 Ile Ser Ser Thr Ser Tyr Lys Glu Val Cys Ile Pro Glu Ile Val Ser
                 550                 555                 560

 ggc agc aag gaa ccg tcc agc gct tgc agc ctt ttg gag cca gga aaa     3166
 Gly Ser Lys Glu Pro Ser Ser Ala Cys Ser Leu Leu Glu Pro Gly Lys
             565                 570                 575

 cca ccc gag agt ttg cca tcc tat ggc gaa ctc aac tct tgt cca aca     3214
 Pro Pro Glu Ser Leu Pro Ser Tyr Gly Glu Leu Asn Ser Cys Pro Thr
         580                 585                 590

 aaa aca gcc aca gat gac tat ttc cag tgc aac acc tct agt gag acg     3262
 Lys Thr Ala Thr Asp Asp Tyr Phe Gln Cys Asn Thr Ser Ser Glu Thr
     595                 600                 605

 gtg ctc acg gca cca tca cct ctg gga aag aat aag gag gac cat gac     3310
 Val Leu Thr Ala Pro Ser Pro Leu Gly Lys Asn Lys Glu Asp His Asp
 610                 615                 620                 625

 act ctg act ttg gca gaa ggg gtg aaa aag ctc tcc cct tct gat agg     3358
 Thr Leu Thr Leu Ala Glu Gly Val Lys Lys Leu Ser Pro Ser Asp Arg
                 630                 635                 640

 cag gtc ccc cac tcc tcc agg gag cct gtg ggg cac aag gag gag tca     3406
 Gln Val Pro His Ser Ser Arg Glu Pro Val Gly His Lys Glu Glu Ser
             645                 650                 655

 cca aaa ggg ccg ggt ggg ggc ccc gct gct tcg gga gga gtg gct gaa     3454
 Pro Lys Gly Pro Gly Gly Gly Pro Ala Ala Ser Gly Gly Val Ala Glu
         660                 665                 670

 ggg atc gcc aac gga cgc ctc gtc cag cac cat ggt gcc gag ccc agc     3502
 Gly Ile Ala Asn Gly Arg Leu Val Gln His His Gly Ala Glu Pro Ser
     675                 680                 685

 agc ttg gac aag agg aaa gag ata ttt agc aaa gac aca ctg ttc aaa     3550
 Ser Leu Asp Lys Arg Lys Glu Ile Phe Ser Lys Asp Thr Leu Phe Lys
 690                 695                 700                 705

 cct ctt cac agc acc ttg tct gta aac agc tat cac aag tcg agc ctg     3598
 Pro Leu His Ser Thr Leu Ser Val Asn Ser Tyr His Lys Ser Ser Leu
                 710                 715                 720

 tcc ctc ctc aaa tct cac ccg aag aca cct gct gac aca ttg cca ggc     3646
 Ser Leu Leu Lys Ser His Pro Lys Thr Pro Ala Asp Thr Leu Pro Gly
             725                 730                 735

 cga tgt gag aaa ctg gaa ccg tcc ctg ggg acc tcg gcg gca caa gcc     3694
 Arg Cys Glu Lys Leu Glu Pro Ser Leu Gly Thr Ser Ala Ala Gln Ala
         740                 745                 750

 atg cct gct tcc cag cgt cag cag gag tca gga ggg aac cag gaa gcc     3742
 Met Pro Ala Ser Gln Arg Gln Gln Glu Ser Gly Gly Asn Gln Glu Ala
     755                 760                 765

 tct ttt gac tat tac aac gtc tct gat gat gac gac tct gag gaa ggg     3790
 Ser Phe Asp Tyr Tyr Asn Val Ser Asp Asp Asp Asp Ser Glu Glu Gly
 770                 775                 780                 785

 gca aac aag aac aca gag gag gag aaa aat aga gag gac gta ggc acc     3838
 Ala Asn Lys Asn Thr Glu Glu Glu Lys Asn Arg Glu Asp Val Gly Thr
                 790                 795                 800

 atg cag tgg ctc ctc gag cgg gag aag gaa aga gac ttg cag agg aaa     3886
 Met Gln Trp Leu Leu Glu Arg Glu Lys Glu Arg Asp Leu Gln Arg Lys
             805                 810                 815

 ttt gaa aag aac ctc acc ctt ctt gct cca aaa gaa acc gac agc agc     3934
 Phe Glu Lys Asn Leu Thr Leu Leu Ala Pro Lys Glu Thr Asp Ser Ser
         820                 825                 830

 agc aac cag aga gcc acc cat tca gcc cgg ctc gac agc atg gac agc     3982
 Ser Asn Gln Arg Ala Thr His Ser Ala Arg Leu Asp Ser Met Asp Ser
     835                 840                 845

 agc agc atc aca gtg gac agt gga ttc aac tcc cca cgt act cgg gag     4030
 Ser Ser Ile Thr Val Asp Ser Gly Phe Asn Ser Pro Arg Thr Arg Glu
 850                 855                 860                 865

 agc ctg gct tcc aac aca tca agc att gtt gaa agt aac cgt cgt cag     4078
 Ser Leu Ala Ser Asn Thr Ser Ser Ile Val Glu Ser Asn Arg Arg Gln
                 870                 875                 880

 aac ccc gct ttg agc ccg gcc cat ggt gga gct ggt cca gcc ttc aac     4126
 Asn Pro Ala Leu Ser Pro Ala His Gly Gly Ala Gly Pro Ala Phe Asn
             885                 890                 895

 ttc cga gcg agc gcg gag ccc ccg aca aat gaa gct gag aag cta cag     4174
 Phe Arg Ala Ser Ala Glu Pro Pro Thr Asn Glu Ala Glu Lys Leu Gln
         900                 905                 910

 aaa cct tcc aac tgc ttg caa gct tct gtt act agc gtg tga ttgtcct     4223
 Lys Pro Ser Asn Cys Leu Gln Ala Ser Val Thr Ser Val 
     915                 920                 925

 tctgcctcag atcttctgtc tcattcgata cagcaaagtt tacgacactg ggactgatgt   4283

 ttacatcttt ggaaagacaa gcatctcaac cacagttttt gtgtttactt aaactgtgct   4343

 gctaagtagg gctagggcaa aaaaacaaaa aatctttatt tcagagtatt gcttttcaca   4403

 tttatggctc tgtagcaact gagtaacagt aggggtgata tgtatacttt tgcttcacta   4463

 attgtatctg agcacacata ggaaagtcta gacactgtaa gtgtaatacg cattttcaat   4523

 gtcatgcagt tgccaattcc attttaaaat gccacagatg cgtgttgctc ccagtctgtg   4583

 gttaaacggt gccacagaac tgatccttga cacttccaaa aaaaaaaaaa              4633




      <210> 295
      <211> 972
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(952)

      <400> 295
 tcgtagtcat tagtccagtg cggtggaatt cagagaagag aggcgcctgc gcttgcgagc     60

 tgggcttgtg agtggggctg ccgagagggc aggcgtgggg cgaggccaaa ggactgaacc    120

 cgcaggagcg tcacgggcgc cggggcggct gccgacggcg ggactgggtt ttctatcaga    180

 tgttccacgt aataatgctg ggtaatccaa atctatttct ggaacc   atg aaa att     235
                                                      Met Lys Ile
                                                        1

 ttg cta gtt ttt gac ttt gac aat aca atc ata gat gac aat agt gac      283
 Leu Leu Val Phe Asp Phe Asp Asn Thr Ile Ile Asp Asp Asn Ser Asp
       5                  10                  15

 act tgg att gta caa tgt gct ccc aac aaa aag ctt cct att gaa cta      331
 Thr Trp Ile Val Gln Cys Ala Pro Asn Lys Lys Leu Pro Ile Glu Leu
  20                  25                  30                  35

 cgt gat tct tat cga aaa gga ttt tgg aca gaa ttt atg ggc aga gtc      379
 Arg Asp Ser Tyr Arg Lys Gly Phe Trp Thr Glu Phe Met Gly Arg Val
                  40                  45                  50

 ttt aag tat ttg gga gat aag ggt gta aga gaa cat gaa atg aaa aga      427
 Phe Lys Tyr Leu Gly Asp Lys Gly Val Arg Glu His Glu Met Lys Arg
              55                  60                  65

 gca gtg aca tca ttg cct ttc act cca ggg atg gtg gaa ctc ttc aac      475
 Ala Val Thr Ser Leu Pro Phe Thr Pro Gly Met Val Glu Leu Phe Asn
          70                  75                  80

 ttt ata aga aag aat aag gat aaa ttt gac tgc att att att tca gat      523
 Phe Ile Arg Lys Asn Lys Asp Lys Phe Asp Cys Ile Ile Ile Ser Asp
      85                  90                  95

 tca aat tcg gtc ttc ata gat tgg gtt tta gaa gct gcc agt ttt cat      571
 Ser Asn Ser Val Phe Ile Asp Trp Val Leu Glu Ala Ala Ser Phe His
 100                 105                 110                 115

 gac ata ttt gat aaa gtg ttt aca aat cca gca gct ttt aat agc aat      619
 Asp Ile Phe Asp Lys Val Phe Thr Asn Pro Ala Ala Phe Asn Ser Asn
                 120                 125                 130

 ggt cat ctc act gtt gaa aat tat cat act cat tct tgc aat aga tgc      667
 Gly His Leu Thr Val Glu Asn Tyr His Thr His Ser Cys Asn Arg Cys
             135                 140                 145

 cca aag aat ctt tgc aaa aag gta gtt ttg ata gaa ttt gta gat aaa      715
 Pro Lys Asn Leu Cys Lys Lys Val Val Leu Ile Glu Phe Val Asp Lys
         150                 155                 160

 cag tta caa cag gga gtg aat tat aca caa att gtt tat att ggt gat      763
 Gln Leu Gln Gln Gly Val Asn Tyr Thr Gln Ile Val Tyr Ile Gly Asp
     165                 170                 175

 ggt gga aat gat gtc tgt cca gtc acc ttt tta aag aat gat gat gtt      811
 Gly Gly Asn Asp Val Cys Pro Val Thr Phe Leu Lys Asn Asp Asp Val
 180                 185                 190                 195

 gcc atg cca cgg aaa gga tat acc tta cag aaa act ctt tcc aga atg      859
 Ala Met Pro Arg Lys Gly Tyr Thr Leu Gln Lys Thr Leu Ser Arg Met
                 200                 205                 210

 tct caa aat ctt gag cct atg gaa tat tct gtt gta gtt tgg tcc tca      907
 Ser Gln Asn Leu Glu Pro Met Glu Tyr Ser Val Val Val Trp Ser Ser
             215                 220                 225

 ggt gtt gat ata att tct cat tta caa ttt cta ata aag gat taa tat      955
 Gly Val Asp Ile Ile Ser His Leu Gln Phe Leu Ile Lys Asp 
         230                 235                 240

 gtcaaaaaaa aaaaaaa                                                   972




      <210> 296
      <211> 782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(697)

      <400> 296
 gtcagcggga ggcctgaggg cgccgggcgc tgcggcaggc gggcccgggg tccagccgag     60

 aggctcccct gggacctgtg gccgccgccc acagacc atg ctc ctg ggg cgc ctg     115
                                          Met Leu Leu Gly Arg Leu
                                            1               5

 act tcc cag ctg ttg agg gcc gtt cct tgg gca ggc ggc cgc ccg cct      163
 Thr Ser Gln Leu Leu Arg Ala Val Pro Trp Ala Gly Gly Arg Pro Pro
              10                  15                  20

 tgg ccc gtc tct gga gtg ctg ggc agc cgg gtc tgc ggg ccc ctt tac      211
 Trp Pro Val Ser Gly Val Leu Gly Ser Arg Val Cys Gly Pro Leu Tyr
          25                  30                  35

 agc aca tcg ccc gcc ggc cca ggt agg gcg gcc tct ctc cct cgc aag      259
 Ser Thr Ser Pro Ala Gly Pro Gly Arg Ala Ala Ser Leu Pro Arg Lys
      40                  45                  50

 ggg gcc caa ctg gag ctg gag gag atg ctg gtc ccc agg aag atg tcc      307
 Gly Ala Gln Leu Glu Leu Glu Glu Met Leu Val Pro Arg Lys Met Ser
  55                  60                  65                  70

 gtc aag ccc ctg aag agc tgg ctc acg gcc cgc tgc ttc ctg ccc aga      355
 Val Lys Pro Leu Lys Ser Trp Leu Thr Ala Arg Cys Phe Leu Pro Arg
                  75                  80                  85

 ctg gat acc ggg acc gca tgg act gtg gct cca ccg caa tcc tac cag      403
 Leu Asp Thr Gly Thr Ala Trp Thr Val Ala Pro Pro Gln Ser Tyr Gln
              90                  95                 100

 tgt ccg ccc agc cag ata ggg gaa ggg gcc gag cag ggg gat gaa ggc      451
 Cys Pro Pro Ser Gln Ile Gly Glu Gly Ala Glu Gln Gly Asp Glu Gly
         105                 110                 115

 gtc gcg gat gcg cct caa att cag tgc aaa aac gtg ctg aag atc cgc      499
 Val Ala Asp Ala Pro Gln Ile Gln Cys Lys Asn Val Leu Lys Ile Arg
     120                 125                 130

 cgg cgg aag atg aac cac cac aag tac cgg aag ctg gtg aag aag acg      547
 Arg Arg Lys Met Asn His His Lys Tyr Arg Lys Leu Val Lys Lys Thr
 135                 140                 145                 150

 cgg ttc ctg cgg agg aag gtc cag gag gga cgc ctg aga cgc aag cag      595
 Arg Phe Leu Arg Arg Lys Val Gln Glu Gly Arg Leu Arg Arg Lys Gln
                 155                 160                 165

 atc aag ttc gag aaa gac ctg agg cgc atc tgg ctg aag gcg ggg cta      643
 Ile Lys Phe Glu Lys Asp Leu Arg Arg Ile Trp Leu Lys Ala Gly Leu
             170                 175                 180

 aag gaa gcc ccc gaa ggc tgg cag acc ccc aag atc tac ctg cgg ggc      691
 Lys Glu Ala Pro Glu Gly Trp Gln Thr Pro Lys Ile Tyr Leu Arg Gly
         185                 190                 195

 aaa tga gtctgcgccg cccttcccgc ccgttgctgc tgtgatccgt agtaataaat       747
 Lys 


 tctcagagga ctcagccttt aaaaaaaaaa aaaaa                               782




      <210> 297
      <211> 686
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(601)

      <400> 297
 gtcagcggga ggcctgaggg cgccgggcgc tgcggcaggc gggcccgggg tccagccgag     60

 aggctcccct gggacctgtg gccgccgccc acagacc atg ctc ctg ggg cgc ctg     115
                                          Met Leu Leu Gly Arg Leu
                                            1               5

 act tcc cag ctg ttg agg gcc gtt cct tgg gcc tct ctc cct cgc aag      163
 Thr Ser Gln Leu Leu Arg Ala Val Pro Trp Ala Ser Leu Pro Arg Lys
              10                  15                  20

 ggg gcc caa ctg gag ctg gag gag atg ctg gtc ccc agg aag atg tcc      211
 Gly Ala Gln Leu Glu Leu Glu Glu Met Leu Val Pro Arg Lys Met Ser
          25                  30                  35

 gtc aag ccc ctg aag agc tgg ctc acg gcc cgc tgc ttc ctg ccc aga      259
 Val Lys Pro Leu Lys Ser Trp Leu Thr Ala Arg Cys Phe Leu Pro Arg
      40                  45                  50

 ctg gat acc ggg acc gca tgg act gtg gct cca ccg caa tcc tac cag      307
 Leu Asp Thr Gly Thr Ala Trp Thr Val Ala Pro Pro Gln Ser Tyr Gln
  55                  60                  65                  70

 tgt ccg ccc agc cag ata ggg gaa ggg gcc gag cag ggg gat gaa ggc      355
 Cys Pro Pro Ser Gln Ile Gly Glu Gly Ala Glu Gln Gly Asp Glu Gly
                  75                  80                  85

 gtc gcg gat gcg cct caa att cag tgc aaa aac gtg ctg aag atc cgc      403
 Val Ala Asp Ala Pro Gln Ile Gln Cys Lys Asn Val Leu Lys Ile Arg
              90                  95                 100

 cgg cgg aag atg aac cac cac aag tac cgg aag ctg gtg aag aag acg      451
 Arg Arg Lys Met Asn His His Lys Tyr Arg Lys Leu Val Lys Lys Thr
         105                 110                 115

 cgg ttc ctg cgg agg aag gtc cag gag gga cgc ctg aga cgc aag cag      499
 Arg Phe Leu Arg Arg Lys Val Gln Glu Gly Arg Leu Arg Arg Lys Gln
     120                 125                 130

 atc aag ttc gag aaa gac ctg agg cgc atc tgg ctg aag gcg ggg cta      547
 Ile Lys Phe Glu Lys Asp Leu Arg Arg Ile Trp Leu Lys Ala Gly Leu
 135                 140                 145                 150

 aag gaa gcc ccc gaa ggc tgg cag acc ccc aag atc tac ctg cgg ggc      595
 Lys Glu Ala Pro Glu Gly Trp Gln Thr Pro Lys Ile Tyr Leu Arg Gly
                 155                 160                 165

 aaa tga gtctgcgccg cccttcccgc ccgttgctgc tgtgatccgt agtaataaat       651
 Lys 


 tctcagagga ctcagccttt aaaaaaaaaa aaaaa                               686




      <210> 298
      <211> 964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (251)..(841)

      <400> 298
 acacaattta acactcacta tagggatttg ccctcgaggc cagaattcgg cacgagagaa     60

 ggcgggtcct tgctttgttg cctcggcttg tttgaaactc ctgggctcaa gtgatcctcc    120

 tgcctcggcc tcccacagtg ctgggattac aggtgtgagc cactgcacca ggatggattt    180

 gtcttccttc agaagacagt agctgatgtg tgccctggcc tttctcccct aggattcagc    240

 agtggccacc   atg ggt tct gtg aat tcc aga ggt cac aag gcg gaa gcc     289
              Met Gly Ser Val Asn Ser Arg Gly His Lys Ala Glu Ala
                1               5                  10

 cag gtg gtg atg atg ggc ctg gac tcg gcg ggc aag acc acg ctc ctt      337
 Gln Val Val Met Met Gly Leu Asp Ser Ala Gly Lys Thr Thr Leu Leu
      15                  20                  25

 tac aag ctg aag ggc cac cag ctg gtg gag acc ctg ccc act gtt ggt      385
 Tyr Lys Leu Lys Gly His Gln Leu Val Glu Thr Leu Pro Thr Val Gly
  30                  35                  40                  45

 ttc aac gtg gag cct ctg aaa gct cct ggg cac gtg tca ctg act ctc      433
 Phe Asn Val Glu Pro Leu Lys Ala Pro Gly His Val Ser Leu Thr Leu
                  50                  55                  60

 tgg gac gtt ggg ggg cag gcc ccg ctc aga gcc agc tgg aag gac tat      481
 Trp Asp Val Gly Gly Gln Ala Pro Leu Arg Ala Ser Trp Lys Asp Tyr
              65                  70                  75

 ctg gaa ggc aca gat atc ctc gtg tac gtg ctg gac agc aca gat gaa      529
 Leu Glu Gly Thr Asp Ile Leu Val Tyr Val Leu Asp Ser Thr Asp Glu
          80                  85                  90

 gcc cgc tta ccc gag tcg gcg gct gag ctc aca gaa gtc ctg aac gac      577
 Ala Arg Leu Pro Glu Ser Ala Ala Glu Leu Thr Glu Val Leu Asn Asp
      95                 100                 105

 ccc aac atg gct ggc gtc ccc ttc ttg gtg ctg gcc aac aag cag gag      625
 Pro Asn Met Ala Gly Val Pro Phe Leu Val Leu Ala Asn Lys Gln Glu
 110                 115                 120                 125

 gca cct gat gca ctt ccg ctg ctt aag atc aga aac agg ctg agt cta      673
 Ala Pro Asp Ala Leu Pro Leu Leu Lys Ile Arg Asn Arg Leu Ser Leu
                 130                 135                 140

 gag aga ttc cag gac cac tgc tgg gag ctc cgg ggc tgc agt gcc ctc      721
 Glu Arg Phe Gln Asp His Cys Trp Glu Leu Arg Gly Cys Ser Ala Leu
             145                 150                 155

 act ggg gag ggg ctg ccc gag gcc ctg cag agc ctg tgg agc ctc ctg      769
 Thr Gly Glu Gly Leu Pro Glu Ala Leu Gln Ser Leu Trp Ser Leu Leu
         160                 165                 170

 aaa tct cgc agc tgc atg tgt ctg cag gcg aga gcc cat ggg gct gag      817
 Lys Ser Arg Ser Cys Met Cys Leu Gln Ala Arg Ala His Gly Ala Glu
     175                 180                 185

 cgc gga gac ggc aag aga tct tga tccagacaga gcagcatatc tttgctcata     871
 Arg Gly Asp Gly Lys Arg Ser 
 190                 195

 caaactagaa gaaccagctg atccttgaga aatttacgct tagtctatca aacaagaaat    931

 gctggcttgg cccggtggct catgcctgta ata                                 964




      <210> 299
      <211> 2743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(2480)

      <400> 299
 cgcaggagag ccagtaccag tgcctggagt gtggtcaact gctg atg tca ccc agc      56
                                                  Met Ser Pro Ser
                                                    1

 cag ctc ctg gag cac cag gag ctg cac ctg aag atg atg gca ccc cag      104
 Gln Leu Leu Glu His Gln Glu Leu His Leu Lys Met Met Ala Pro Gln
   5                  10                  15                  20

 gag gca gtg cca gct gag cca tca cct aag gca cca ccc ctg agc tcc      152
 Glu Ala Val Pro Ala Glu Pro Ser Pro Lys Ala Pro Pro Leu Ser Ser
                  25                  30                  35

 agc acc atc cac tac gag tgt gtg gat tgc aag gct ctc ttt gcc agc      200
 Ser Thr Ile His Tyr Glu Cys Val Asp Cys Lys Ala Leu Phe Ala Ser
              40                  45                  50

 cag gag ctc tgg ctg aac cac cgg cag acg cac ctc cgg gcc aca ccc      248
 Gln Glu Leu Trp Leu Asn His Arg Gln Thr His Leu Arg Ala Thr Pro
          55                  60                  65

 acc aag gct cct gcc cct gtt gtc ctg ggg tcc cca gtt gtt cta ggg      296
 Thr Lys Ala Pro Ala Pro Val Val Leu Gly Ser Pro Val Val Leu Gly
      70                  75                  80

 cct cct gtg ggc cag gcc cga gtg gct gtg gag cac tca tac cga aag      344
 Pro Pro Val Gly Gln Ala Arg Val Ala Val Glu His Ser Tyr Arg Lys
  85                  90                  95                 100

 gca gaa gag ggt ggg gaa ggg gcg act gtc cca tct gcc gct gcc acc      392
 Ala Glu Glu Gly Gly Glu Gly Ala Thr Val Pro Ser Ala Ala Ala Thr
                 105                 110                 115

 acc act gag gta gtg act gag gtg gag ctg ctc ctc tac aag tgc ttt      440
 Thr Thr Glu Val Val Thr Glu Val Glu Leu Leu Leu Tyr Lys Cys Phe
             120                 125                 130

 gag tgc tcc cag ctc ttc cag ctg cgg ggg gat ttc ttg gag cac cag      488
 Glu Cys Ser Gln Leu Phe Gln Leu Arg Gly Asp Phe Leu Glu His Gln
         135                 140                 145

 gcc act cat ttc cct gtt cct gta ccc gag ttt cag gag cct gcc tta      536
 Ala Thr His Phe Pro Val Pro Val Pro Glu Phe Gln Glu Pro Ala Leu
     150                 155                 160

 cag cag gag gtg cag gcc tcg tca cct gca gag gtg cct gtg tct cag      584
 Gln Gln Glu Val Gln Ala Ser Ser Pro Ala Glu Val Pro Val Ser Gln
 165                 170                 175                 180

 cct gac ccc ttg cca gct ttt gac cac agt tac gag ctg cgc aat ggt      632
 Pro Asp Pro Leu Pro Ala Phe Asp His Ser Tyr Glu Leu Arg Asn Gly
                 185                 190                 195

 gaa gcc att ggg cgg gat cgc cgg ggg cgc agg gcc cgg agg aac aac      680
 Glu Ala Ile Gly Arg Asp Arg Arg Gly Arg Arg Ala Arg Arg Asn Asn
             200                 205                 210

 agt gga gaa gca ggc ggg gca gcc aca cag gag ctc ttc tgc tca gcc      728
 Ser Gly Glu Ala Gly Gly Ala Ala Thr Gln Glu Leu Phe Cys Ser Ala
         215                 220                 225

 tgt gac cag ctc ttt ctc tca ccc cac cag cta cag cag cac ctg cgg      776
 Cys Asp Gln Leu Phe Leu Ser Pro His Gln Leu Gln Gln His Leu Arg
     230                 235                 240

 agt cac cgg gag ggc gtc ttt aag tgc ccc ctg tgc agt cgt gtc ttc      824
 Ser His Arg Glu Gly Val Phe Lys Cys Pro Leu Cys Ser Arg Val Phe
 245                 250                 255                 260

 cct agc cct tcc agt ctg gac cag cac ctt gga gac cat agc agc gag      872
 Pro Ser Pro Ser Ser Leu Asp Gln His Leu Gly Asp His Ser Ser Glu
                 265                 270                 275

 tca cac ttc ctg tgt gta gac tgt ggc ctg gcc ttc ggc aca gag gcc      920
 Ser His Phe Leu Cys Val Asp Cys Gly Leu Ala Phe Gly Thr Glu Ala
             280                 285                 290

 ctc ctc ctg gcc cac cgg cga gcc cac acc ccg aat cct ctg cat tca      968
 Leu Leu Leu Ala His Arg Arg Ala His Thr Pro Asn Pro Leu His Ser
         295                 300                 305

 tgt cca tgt ggg aag acc ttt gtc aac ctt acc aag ttc ctt tat cac     1016
 Cys Pro Cys Gly Lys Thr Phe Val Asn Leu Thr Lys Phe Leu Tyr His
     310                 315                 320

 cgg cgt act cat ggg gta ggg ggt gtc cct ctg ccc aca aca cca gtc     1064
 Arg Arg Thr His Gly Val Gly Gly Val Pro Leu Pro Thr Thr Pro Val
 325                 330                 335                 340

 cca cca gag gaa cct gtc att ggt ttc cct gag cca gcc cca gca gag     1112
 Pro Pro Glu Glu Pro Val Ile Gly Phe Pro Glu Pro Ala Pro Ala Glu
                 345                 350                 355

 act gga gag cca gag gcc cct gag ccc cct gtg tct gag gag acc tca     1160
 Thr Gly Glu Pro Glu Ala Pro Glu Pro Pro Val Ser Glu Glu Thr Ser
             360                 365                 370

 gca ggg ccc gct gcc cca ggc acc tac cgc tgc ctc ctg tgc agc cgt     1208
 Ala Gly Pro Ala Ala Pro Gly Thr Tyr Arg Cys Leu Leu Cys Ser Arg
         375                 380                 385

 gaa ttt gga aag gcc ttg cag ctg acc cgg cac caa cgt ttt gtg cat     1256
 Glu Phe Gly Lys Ala Leu Gln Leu Thr Arg His Gln Arg Phe Val His
     390                 395                 400

 cgg ctg gag cgg cgc cat aaa tgc agc att tgt ggc aag atg ttc aag     1304
 Arg Leu Glu Arg Arg His Lys Cys Ser Ile Cys Gly Lys Met Phe Lys
 405                 410                 415                 420

 aag aag tct cac gtg cgt aac cac ctg cgc aca cac aca ggg gag cgg     1352
 Lys Lys Ser His Val Arg Asn His Leu Arg Thr His Thr Gly Glu Arg
                 425                 430                 435

 ccc ttc ccc tgc cct gac tgc tcc aag ccc ttc aac tca cct gcc aac     1400
 Pro Phe Pro Cys Pro Asp Cys Ser Lys Pro Phe Asn Ser Pro Ala Asn
             440                 445                 450

 ctg gcc cgc cac cgg ctc aca cac aca gga gag cgg ccc tac cgg tgt     1448
 Leu Ala Arg His Arg Leu Thr His Thr Gly Glu Arg Pro Tyr Arg Cys
         455                 460                 465

 ggg gac tgt ggc aag gct ttc acg caa agc tcc aca ctg agg cag cac     1496
 Gly Asp Cys Gly Lys Ala Phe Thr Gln Ser Ser Thr Leu Arg Gln His
     470                 475                 480

 cgc ttg gtg cat gcc cag cac ttc ccc tac cgc tgc cag gaa tgt ggg     1544
 Arg Leu Val His Ala Gln His Phe Pro Tyr Arg Cys Gln Glu Cys Gly
 485                 490                 495                 500

 gtg cgt ttt cac cgt cct tac cgc ctg ctc atg cac cgc tac cat cac     1592
 Val Arg Phe His Arg Pro Tyr Arg Leu Leu Met His Arg Tyr His His
                 505                 510                 515

 aca ggt gaa tac ccc tac aag tgt cgc gag tgc ccc cgc tcc ttc ttg     1640
 Thr Gly Glu Tyr Pro Tyr Lys Cys Arg Glu Cys Pro Arg Ser Phe Leu
             520                 525                 530

 ctg cgt cgg ctg ctg gag gtg cac cag ctc gtg gtc cat gcc ggg cgc     1688
 Leu Arg Arg Leu Leu Glu Val His Gln Leu Val Val His Ala Gly Arg
         535                 540                 545

 cag ccc cac cgc tgc cca tcc tgt ggg gct gcc ttc ccc tcc tca ctg     1736
 Gln Pro His Arg Cys Pro Ser Cys Gly Ala Ala Phe Pro Ser Ser Leu
     550                 555                 560

 cgg ctc cgg gag cac cgc tgt gca gcc gct gct gcc cag gcc cca cgg     1784
 Arg Leu Arg Glu His Arg Cys Ala Ala Ala Ala Ala Gln Ala Pro Arg
 565                 570                 575                 580

 cgc ttt gag tgt ggc acc tgt ggc aag aaa gtg ggc tca gct gct cga     1832
 Arg Phe Glu Cys Gly Thr Cys Gly Lys Lys Val Gly Ser Ala Ala Arg
                 585                 590                 595

 ctg cag gca cac gag gcg gcc cat gca gct gct ggg cct gga gag gtc     1880
 Leu Gln Ala His Glu Ala Ala His Ala Ala Ala Gly Pro Gly Glu Val
             600                 605                 610

 ctg gct aag gag ccc cct gcc cct cga gcc cca cgg gcc act cgt gca     1928
 Leu Ala Lys Glu Pro Pro Ala Pro Arg Ala Pro Arg Ala Thr Arg Ala
         615                 620                 625

 cca gtt gcc tct cca gca gcc ctt gga agc act gct aca gca tcc cct     1976
 Pro Val Ala Ser Pro Ala Ala Leu Gly Ser Thr Ala Thr Ala Ser Pro
     630                 635                 640

 gcg gcc cct gcc cgc cgc cgg ggt cta gag tgc agc gag tgc aag aag     2024
 Ala Ala Pro Ala Arg Arg Arg Gly Leu Glu Cys Ser Glu Cys Lys Lys
 645                 650                 655                 660

 ctg ttc agc aca gag acg tca ctg cag gtg cac cgg cgc atc cac aca     2072
 Leu Phe Ser Thr Glu Thr Ser Leu Gln Val His Arg Arg Ile His Thr
                 665                 670                 675

 ggt gag cgg cca tac cca tgt cca gac tgt ggc aaa gcg ttc cgt cag     2120
 Gly Glu Arg Pro Tyr Pro Cys Pro Asp Cys Gly Lys Ala Phe Arg Gln
             680                 685                 690

 agt acc cac ctg aaa gac cac cgg cgc ctg cac aca ggt gag cgg ccc     2168
 Ser Thr His Leu Lys Asp His Arg Arg Leu His Thr Gly Glu Arg Pro
         695                 700                 705

 ttt gcc tgt gaa gtg tgt ggc aag gcc ttt gcc atc tcc atg cgc ctg     2216
 Phe Ala Cys Glu Val Cys Gly Lys Ala Phe Ala Ile Ser Met Arg Leu
     710                 715                 720

 gca gaa cat cgc cgc atc cac aca ggc gaa cga ccc tac tcc tgc cct     2264
 Ala Glu His Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Ser Cys Pro
 725                 730                 735                 740

 gac tgt ggc aag agc tac cgc tcc ttc tcc aac ctc tgg aag cac cgc     2312
 Asp Cys Gly Lys Ser Tyr Arg Ser Phe Ser Asn Leu Trp Lys His Arg
                 745                 750                 755

 aag acc cat cag cag cag cat cag gca gct gtg cgg cag cag ctg gca     2360
 Lys Thr His Gln Gln Gln His Gln Ala Ala Val Arg Gln Gln Leu Ala
             760                 765                 770

 gag gcg gag gct gcc gtt ggc ctg gcc gtc atg gag act gct gtg gag     2408
 Glu Ala Glu Ala Ala Val Gly Leu Ala Val Met Glu Thr Ala Val Glu
         775                 780                 785

 gcg cta ccc ctg gtg gaa gcc att gag atc tac cct ctg gcc gag gct     2456
 Ala Leu Pro Leu Val Glu Ala Ile Glu Ile Tyr Pro Leu Ala Glu Ala
     790                 795                 800

 gag ggg gtc cag atc agt ggc tga ctctgcccga cttcctcttt ggcacctcca    2510
 Glu Gly Val Gln Ile Ser Gly 
 805                 810

 ttccctgttg ctgaaggccc tccagcatcc ccttaagcat ctgtacatac tgtgtccctt   2570

 cctcttccca tccccaccac cttgtaagtt ctaaattgga tttattctct cgtgaggggg   2630

 gtgctctggg gtccttgaca cacataaagg tgccccccca ccttccacct cttagcactg   2690

 gtgaccccaa aaatgaaacc atcaataaag actgagttgc caaaaaaaaa aaa          2743




      <210> 300
      <211> 748
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(370)

      <400> 300
 ggcccgagcg gagccggccg cg atg agc ggg gag ccg ggg cag acg tcc gta      52
                          Met Ser Gly Glu Pro Gly Gln Thr Ser Val
                            1               5                  10

 gcg ccc cct ccc gag gag gtc gag ccg ggc agt ggg gtc cgc atc gtg      100
 Ala Pro Pro Pro Glu Glu Val Glu Pro Gly Ser Gly Val Arg Ile Val
                  15                  20                  25

 gtg gag tac tgt gaa ccc tgc ggc ttc gag gcg acc tac ctg gag ctg      148
 Val Glu Tyr Cys Glu Pro Cys Gly Phe Glu Ala Thr Tyr Leu Glu Leu
              30                  35                  40

 gcc agt gct gtg aag gag cag tat ccg ggc atc gag atc gag tcg cgc      196
 Ala Ser Ala Val Lys Glu Gln Tyr Pro Gly Ile Glu Ile Glu Ser Arg
          45                  50                  55

 ctc ggg ggc aca ggt gcc ttt gag ata gag ata aat gga cag ctg gtg      244
 Leu Gly Gly Thr Gly Ala Phe Glu Ile Glu Ile Asn Gly Gln Leu Val
      60                  65                  70

 ttc tcc aag ctg gag aat ggg ggc ttt ccc tat gag aaa gat ctc att      292
 Phe Ser Lys Leu Glu Asn Gly Gly Phe Pro Tyr Glu Lys Asp Leu Ile
  75                  80                  85                  90

 gag gcc atc cga aga gcc agt aat gga gaa acc cta gaa aag atc acc      340
 Glu Ala Ile Arg Arg Ala Ser Asn Gly Glu Thr Leu Glu Lys Ile Thr
                  95                 100                 105

 aac agc cgt cct ccc tgc gtc atc ctg tga c tgcacaggac tctgggttcc      391
 Asn Ser Arg Pro Pro Cys Val Ile Leu 
             110                 115

 tgctctgttc tggggtccaa accttggtct ccctttggtc ctgctgggag ctccccctgc    451

 ctctttcccc tacttagctc cttagcaaag agaccctggc ctccactttg ccctttgggt    511

 acaaagaagg aatagaagat tccgtggcct tgggggcagg agagagacac tctccatgaa    571

 cacttctcca gccacctcat acccccttcc cagggtaagt gcccacgaaa gcccagtcca    631

 ctcttcgcct cggtaatacc tgtctgatgc cacagatttt atttattctc ccctaaccca    691

 gggcaatgtc agctattggc agtaaagtgg cgctacagac aaaataaaaa aaaaaaa       748




      <210> 301
      <211> 1001
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (798)..(992)

      <400> 301
 agacattctg gttaatagag taggaagggt cttacagatg gagaaatgaa gacccacgga     60

 catctcctga tgcacaaact tctcacaagt gacctggagg ggcttggttc taatcttgtc    120

 cctggactgc accaactggg gcactgacat tctatgtggt cctctattac cattgggctg    180

 gtcctgtctt ccaggaacca gggcctctcc cactgcaacc agaatggcct cagattctag    240

 ggttagcatt gacccagtaa ctacataaaa aagtggaata gattaaatag aacctcagac    300

 aaatcacaga aatggggcta aacctagcca gcctgagctt cagatttaaa agttctcttt    360

 ctttatacca gggaaatcaa aacctggatg ttgtcttctc tttttcttct ggctttgaca    420

 tagttaacaa gccctaggat gtctgcactg gaaaaatggg agatctcatt tagtccaaac    480

 tcctcctctg ttaagagacc tggaataaag ccactattaa tcaactatta gtttggtgac    540

 tattagtcaa agccaggacc agagccagaa gctggacttt cctttcccct ggccaaacct    600

 tgtgtgcaca ctgtttcttc ccctccccac cctgtcaggc cattgatgtg atggctcccc    660

 attcacacct tcatttctcc tctttaacgt gaccagggct gttctgaacc tccttacttt    720

 ggcctcctct gcccagaaca ggtcaggccc ctctgcatcc atcaaccagg tgtgctctcc    780

 tgaccattct ttgtcag   atg ggc acc ttc act aac tca gct ctt tgg att     830
                      Met Gly Thr Phe Thr Asn Ser Ala Leu Trp Ile
                        1               5                  10

 gct ttg cag att atg ttt gag act ttc aat gtc cca gcc atg tat gtg      878
 Ala Leu Gln Ile Met Phe Glu Thr Phe Asn Val Pro Ala Met Tyr Val
              15                  20                  25

 gct atc cag gcg gag ctg tct ctc tat gcc tct gga cgc aca act ggt      926
 Ala Ile Gln Ala Glu Leu Ser Leu Tyr Ala Ser Gly Arg Thr Thr Gly
          30                  35                  40

 agg tgg ctg ggc ggg aca gca agc tgg ttg gag cgc act gcc aga gat      974
 Arg Trp Leu Gly Gly Thr Ala Ser Trp Leu Glu Arg Thr Ala Arg Asp
      45                  50                  55

 ggg att gaa tgg tcg taa cacgtgcgg                                   1001
 Gly Ile Glu Trp Ser 
  60





      <210> 302
      <211> 1555
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(699)

      <400> 302
 gcgctcactg cgcgtgcgct agcgcctctt tcaccactgg gcgctgcgcg ctgcccttcc     60

 ctccgcgcac aggctgccgg ctcaccgctt gctaatggca gccggggtct ccctgggaca    120

 gcaagacctc cgctcaggcc cctctttcga     atg ctc cac gcc ctc ctg cga     171
                                      Met Leu His Ala Leu Leu Arg
                                        1               5

 tct aga atg att cag ggc agg atc ctg ctc ctg acc atc tgc gct gcc      219
 Ser Arg Met Ile Gln Gly Arg Ile Leu Leu Leu Thr Ile Cys Ala Ala
          10                  15                  20

 ggc att ggt ggg act ttt cag ttt ggc tat aac ctc tct atc atc aat      267
 Gly Ile Gly Gly Thr Phe Gln Phe Gly Tyr Asn Leu Ser Ile Ile Asn
      25                  30                  35

 gcc ccg acc ttg cac att cag gaa ttc acc aat gag aca tgg cag gcg      315
 Ala Pro Thr Leu His Ile Gln Glu Phe Thr Asn Glu Thr Trp Gln Ala
  40                  45                  50                  55

 cgt act gga gag cca ctg ccc gat cac cta gtc ctg ctt atg tgg tcc      363
 Arg Thr Gly Glu Pro Leu Pro Asp His Leu Val Leu Leu Met Trp Ser
                  60                  65                  70

 ctc atc gtg tct ctg tat ccc ctg gga ggc ctc ttt gga gca ctg ctt      411
 Leu Ile Val Ser Leu Tyr Pro Leu Gly Gly Leu Phe Gly Ala Leu Leu
              75                  80                  85

 gca ggt ccc ttg gcc atc acg ctg gga agg aag aag tcc ctc ctg gtg      459
 Ala Gly Pro Leu Ala Ile Thr Leu Gly Arg Lys Lys Ser Leu Leu Val
          90                  95                 100

 aat aac atc ttt gtg gtg tca gca gca atc ctg ttt gga ttc agc cgc      507
 Asn Asn Ile Phe Val Val Ser Ala Ala Ile Leu Phe Gly Phe Ser Arg
     105                 110                 115

 aaa gca ggc tcc ttt gag atg atc atg ctg gga aga ctg ctc gtg gga      555
 Lys Ala Gly Ser Phe Glu Met Ile Met Leu Gly Arg Leu Leu Val Gly
 120                 125                 130                 135

 gtc aat gca ggt gtg agc atg aac atc cag ccc atg tac ctg ggg gag      603
 Val Asn Ala Gly Val Ser Met Asn Ile Gln Pro Met Tyr Leu Gly Glu
                 140                 145                 150

 agc gcc cct aag gag ctc cga gga gct gtg gcc atg agc tca gcc atc      651
 Ser Ala Pro Lys Glu Leu Arg Gly Ala Val Ala Met Ser Ser Ala Ile
             155                 160                 165

 ttt acg gct ctg ggg atc gtg atg gga cag gtg gtc gga ctc agg taa      699
 Phe Thr Ala Leu Gly Ile Val Met Gly Gln Val Val Gly Leu Arg 
         170                 175                 180

 gcacccctcc cccacatgca ttgagtattt cggagatacc agtaaaagcg tttcttcacc    759

 taaatgtctc ccctacccac tagtagatta aagcattatt gctttgcatg aaggcatcga    819

 atcctctatc cacatctctg ctgccaattc acgaaatggg tatcagtcaa cacactgcaa    879

 tgtgaatcac cttttcccat cctctccagg tcagggagca aagaacaggt cttcacagag    939

 gagagggtga agatttgggc tttcaaagac aaacgtgttc cagtcattcc agaaaaaaga    999

 ggagaaggca gagcctggac ccttgggaag aggagttgct agggatgagg tggggcagtg   1059

 gccctgtcct ctcttggtcc caacctgggt gggagggatc ttgatgttca gacccagact   1119

 tggataggaa gaggcacggg gcaattgcag actccctgca gggaggtgtg taggtgggca   1179

 ggagagcagg gtggtaggac tctggcaaag aggcatctgg cctggcctct cctctgcctc   1239

 cttagggagc tcctaggtgg ccctcaggcc tggcccctgc tgctggccag ctgcctggtg   1299

 cccggggcgc tccagctcgc ctccctgcct ctgctccctg aaagcccgcg ctacctcctc   1359

 attgactgtg gagacaccga ggcctgcctg gcaggtgagt ctctgtcctt gggctcccag   1419

 actgcccttg accaagggat gcatctcccc agagtatacg ggtccccatt tcataggttt   1479

 catttatcaa ggaaaagcta tccctctctt tgtgcctcaa tttcatgatc tgcctatacc   1539

 tgccttcaat cagaac                                                   1555




      <210> 303
      <211> 1389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(1108)

      <400> 303
 tggtcctcgt agttcactgt ggtggaattc cgcggggttg ggcggtcgct gccgggggca     60

 ccgcatccgc cgggcggagg agcgcgccga ggagctgcgg aacaagattg tggaccagtg    120

 tgagaggctg cagttacaga gtgctgccat caccaagtat gtggcggacg tcctgccggg    180

 gaagaatcaa agagcagtga gc atg gcc agt gca gcg agg gaa ctg gtt atc     232
                          Met Ala Ser Ala Ala Arg Glu Leu Val Ile
                            1               5                  10

 cag cgg ttg agt ctg gtg agg agt ctt tgc gag agc gag gag cag cgg      280
 Gln Arg Leu Ser Leu Val Arg Ser Leu Cys Glu Ser Glu Glu Gln Arg
                  15                  20                  25

 tta ctg gaa cag gtg cat ggc gaa gag gag cgg gcc cac cag agc atc      328
 Leu Leu Glu Gln Val His Gly Glu Glu Glu Arg Ala His Gln Ser Ile
              30                  35                  40

 ctg aca cag cgg gtg cac tgg gcc gag gcg ctg cag aag ctt gac acc      376
 Leu Thr Gln Arg Val His Trp Ala Glu Ala Leu Gln Lys Leu Asp Thr
          45                  50                  55

 atc cgc act ggc ctg gtg ggc atg ctt act cac ctg gat gac ctc cag      424
 Ile Arg Thr Gly Leu Val Gly Met Leu Thr His Leu Asp Asp Leu Gln
      60                  65                  70

 ctg att cag aag gag caa gag att ttc gag agg acc gaa gaa gca gag      472
 Leu Ile Gln Lys Glu Gln Glu Ile Phe Glu Arg Thr Glu Glu Ala Glu
  75                  80                  85                  90

 ggc att ttg gat ccc cag gag tcg gaa atg tta aac ttt aat gag aag      520
 Gly Ile Leu Asp Pro Gln Glu Ser Glu Met Leu Asn Phe Asn Glu Lys
                  95                 100                 105

 tgc act cgg agc cca cta ctg acc caa ctc tgg gca acg gcg gtt ctt      568
 Cys Thr Arg Ser Pro Leu Leu Thr Gln Leu Trp Ala Thr Ala Val Leu
             110                 115                 120

 ggg tct ctc tca ggc aca gag gac ata cgg atc gat gag agg aca gtc      616
 Gly Ser Leu Ser Gly Thr Glu Asp Ile Arg Ile Asp Glu Arg Thr Val
         125                 130                 135

 agc ccc ttc ctg caa ttg tca gat gat cga aag acc ctg acc ttc agc      664
 Ser Pro Phe Leu Gln Leu Ser Asp Asp Arg Lys Thr Leu Thr Phe Ser
     140                 145                 150

 acc aag aag tca aag gcc tgt gca gat ggc ccg gag cgc ttc gac cac      712
 Thr Lys Lys Ser Lys Ala Cys Ala Asp Gly Pro Glu Arg Phe Asp His
 155                 160                 165                 170

 tgg ccc aat gcc ctg gct gcc acc tcc ttc cag aat ggg ctc cat gcc      760
 Trp Pro Asn Ala Leu Ala Ala Thr Ser Phe Gln Asn Gly Leu His Ala
                 175                 180                 185

 tgg atg gtg aat gtc cag aac agt tgt gcc tat aag gtg ggc gtg gct      808
 Trp Met Val Asn Val Gln Asn Ser Cys Ala Tyr Lys Val Gly Val Ala
             190                 195                 200

 tca ggc cac ctg ccc cgc aag ggt tct ggc agt gac tgc cgt ctg ggc      856
 Ser Gly His Leu Pro Arg Lys Gly Ser Gly Ser Asp Cys Arg Leu Gly
         205                 210                 215

 cac aat gcc ttc tcc tgg gtc ttc tct cgc tat gat cag gag ttt cgt      904
 His Asn Ala Phe Ser Trp Val Phe Ser Arg Tyr Asp Gln Glu Phe Arg
     220                 225                 230

 ttc tca cac aat ggg cag cac gag ccc ctg ggg ctg ctg cgg ggc cca      952
 Phe Ser His Asn Gly Gln His Glu Pro Leu Gly Leu Leu Arg Gly Pro
 235                 240                 245                 250

 gcc cag ctg ggt gta gtg ctg gac ttg cag gtt cag gag ctg ctc ttc     1000
 Ala Gln Leu Gly Val Val Leu Asp Leu Gln Val Gln Glu Leu Leu Phe
                 255                 260                 265

 tat gag cca gcc tcc ggc aca gtg ctc tgt gcc cat cat gtg tcc ttc     1048
 Tyr Glu Pro Ala Ser Gly Thr Val Leu Cys Ala His His Val Ser Phe
             270                 275                 280

 ccg ggg ccc ctc ttc cca gtc ttt gct gtg gcc gat cag acc att tct     1096
 Pro Gly Pro Leu Phe Pro Val Phe Ala Val Ala Asp Gln Thr Ile Ser
         285                 290                 295

 atc gtc cgc tga cct ctggccacag gaagccaggt ccaccgccca ccaccctttc     1151
 Ile Val Arg 
     300

 aggccatgtt tctactcagt gtgcttttcc caaatgatgt gtgtggtgtt tctaagagaa   1211

 acagggccca taaccagtgg gcagctttag gagggatggg gatctgtttc agatctaggc   1271

 ataacctgta aatcacaggt gtccaaactt ttggcttccc tgggccacat ttgaagaaga   1331

 attttcttgg gccacataaa atacactaac gatagctgat gagctaaaaa aaaaaaaa     1389




      <210> 304
      <211> 731
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(492)

      <400> 304
 ctctgcgaga cccgtccgga attcccgggt cgacgatttc gtggcggagc gctaacgtct     60

 aacgctaacg gcggtcgtgc cccgccgctg ctgtcacccc cggccgctgc tgccctcccc    120

 gccgaggttc tactgctctc cttcttaaga agggtgggag gcactcggtc tctccccaca    180

 cctctcgcct gaggccaggc gccaggtgtc gcctgaagcc agacagccgg tttgggagcg    240

 agcctgagca atttatctca aagcttcaag ttcctgccat ctacatgtgc ccaggtcaac    300

 caatca   atg gct cag aca gat aag cca aca tgc atc ccg ccg gag ctg     348
          Met Ala Gln Thr Asp Lys Pro Thr Cys Ile Pro Pro Glu Leu
            1               5                  10

 ccg aaa atg ctg aag gag ttt gcc aaa gcc gcc att cgg gcg cag ccg      396
 Pro Lys Met Leu Lys Glu Phe Ala Lys Ala Ala Ile Arg Ala Gln Pro
  15                  20                  25                  30

 cag gac ctc atc cag tgg ggg gcc gag aga gac ctc cag agg ctg ctc      444
 Gln Asp Leu Ile Gln Trp Gly Ala Glu Arg Asp Leu Gln Arg Leu Leu
                  35                  40                  45

 agt aga tgg agc tta cac aac aat cgc tgc ggg cct gga ttg aag tag      492
 Ser Arg Trp Ser Leu His Asn Asn Arg Cys Gly Pro Gly Leu Lys 
              50                  55                  60

 ctttgcacag aaagcctctc agctatgaaa ttgctccttg gacaaacttg cctgcttgaa    552

 actggggaac caggacttga gacaggagtt ggaagataac tagacctcac ggaccatttt    612

 caggctattt ttactgtttg atgattccct gcttaggagg gtttcagtgg gaaagtgaga    672

 gtgagagagg ccgttgagag aaagccagtg agttggggaa gggaagatgt cctcaggct     731




      <210> 305
      <211> 2652
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(1174)

      <400> 305
 cggccgcgtc gacgggaaag agccgctagg agcagaccgc gccgccgccg gagccgcgcc     60

 tgcccaggcc cggggaggga ggaggcgggc gtcagggtgc tgcgccccgc tcggcgtccg    120

 agcttccggc cgggctgtgc cccgcgcggt cttcgccggg  atg aag cgc ccc tgc     175
                                              Met Lys Arg Pro Cys
                                                1               5

 gag gag acg acc tcc gag agc gac atg gac gag acc atc gac gtg ggg      223
 Glu Glu Thr Thr Ser Glu Ser Asp Met Asp Glu Thr Ile Asp Val Gly
                  10                  15                  20

 agc gag aac aat tac tcg ggg caa agt act agc tct gtg att aga ttg      271
 Ser Glu Asn Asn Tyr Ser Gly Gln Ser Thr Ser Ser Val Ile Arg Leu
              25                  30                  35

 aat tct cca aca aca aca tct cag att atg gca aga aag aaa agg aga      319
 Asn Ser Pro Thr Thr Thr Ser Gln Ile Met Ala Arg Lys Lys Arg Arg
          40                  45                  50

 ggg att ata gag aaa agg cgt cgg gat cgg ata aat aac agt tta tct      367
 Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Asn Ser Leu Ser
      55                  60                  65

 gag ttg aga aga ctt gtg cca act gct ttt gaa aaa caa gga tct gca      415
 Glu Leu Arg Arg Leu Val Pro Thr Ala Phe Glu Lys Gln Gly Ser Ala
  70                  75                  80                  85

 aag tta gaa aaa gct gaa ata ttg caa atg aca gtg gat cat ttg aag      463
 Lys Leu Glu Lys Ala Glu Ile Leu Gln Met Thr Val Asp His Leu Lys
                  90                  95                 100

 atg ctt cag gca aca ggg ggt aaa ggc tac ttt gac gca cac gct ctt      511
 Met Leu Gln Ala Thr Gly Gly Lys Gly Tyr Phe Asp Ala His Ala Leu
             105                 110                 115

 gcc atg gac ttc atg agc ata gga ttc cga gag tgc cta aca gaa gtt      559
 Ala Met Asp Phe Met Ser Ile Gly Phe Arg Glu Cys Leu Thr Glu Val
         120                 125                 130

 gcg cgg tac ctg agc tcc gtg gaa ggc ctg gac tcc tcg gat ccg ctg      607
 Ala Arg Tyr Leu Ser Ser Val Glu Gly Leu Asp Ser Ser Asp Pro Leu
     135                 140                 145

 cgg gtg cgg ctt gtg tct cat ctc agc act tgc gcc acc cag cgg gag      655
 Arg Val Arg Leu Val Ser His Leu Ser Thr Cys Ala Thr Gln Arg Glu
 150                 155                 160                 165

 gcg gcg gcc atg aca tcc tcc atg gcc cac cac cat cat ccg ctc cac      703
 Ala Ala Ala Met Thr Ser Ser Met Ala His His His His Pro Leu His
                 170                 175                 180

 ccg cat cac tgg gcc gcc gcc ttc cac cac ctg ccc gca gcc ctg ctc      751
 Pro His His Trp Ala Ala Ala Phe His His Leu Pro Ala Ala Leu Leu
             185                 190                 195

 cag ccc aac ggc ctc cat gcc tca gag tca acc cct tgt cgc ctc tcc      799
 Gln Pro Asn Gly Leu His Ala Ser Glu Ser Thr Pro Cys Arg Leu Ser
         200                 205                 210

 aca act tca gaa gtg cct cct gcc cac ggc tct gct ctc ctc acg gcc      847
 Thr Thr Ser Glu Val Pro Pro Ala His Gly Ser Ala Leu Leu Thr Ala
     215                 220                 225

 acg ttt gcc cat gcg gat tca gcc ctc cga atg cca tcc acg ggc agc      895
 Thr Phe Ala His Ala Asp Ser Ala Leu Arg Met Pro Ser Thr Gly Ser
 230                 235                 240                 245

 gtc gcc ccc tgc gtg cca cct ctc tcc acc tct ctc ttg tcc ctc tct      943
 Val Ala Pro Cys Val Pro Pro Leu Ser Thr Ser Leu Leu Ser Leu Ser
                 250                 255                 260

 gcc acc gtc cac gcc gca gcc gca gca gcc acc gcg gct gca cac agc      991
 Ala Thr Val His Ala Ala Ala Ala Ala Ala Thr Ala Ala Ala His Ser
             265                 270                 275

 ttc cct ctg tcc ttc gcg ggg gca ttc ccc atg ctt ccc cca aac gca     1039
 Phe Pro Leu Ser Phe Ala Gly Ala Phe Pro Met Leu Pro Pro Asn Ala
         280                 285                 290

 gca gca gca gtg gcc gcg gcc aca gcc atc agc ccg ccc ttg tca gta     1087
 Ala Ala Ala Val Ala Ala Ala Thr Ala Ile Ser Pro Pro Leu Ser Val
     295                 300                 305

 tca gcc acg tcc agt cct cag cag acc agc agt gga aca aac aat aaa     1135
 Ser Ala Thr Ser Ser Pro Gln Gln Thr Ser Ser Gly Thr Asn Asn Lys
 310                 315                 320                 325

 cct tac cga ccc tgg ggg aca gaa gtt gga gct ttt taa atttttcttg      1184
 Pro Tyr Arg Pro Trp Gly Thr Glu Val Gly Ala Phe 
                 330                 335

 aacttcttgc aatagtaact gaatgtcctc catttcagag tcagcttaaa acctctgcac   1244

 cctgaaggta gccatacaga tgccgacaga tccacaaagg aacaataaag ctatttgaga   1304

 cacaaacctc acgagtggaa atgtggtatt ctcttttttt tctctccctt ttttgtttgg   1364

 ttcaaggcag ctcggtaact gacatcagca acttttgaaa acttcacact tgttaccatt   1424

 tagaagtttc ctggaaaata tatggaccgt accatccagc agtgcatcag tatgtctgaa   1484

 ttggggaagt aaaatgccct gactgaattc tcttgagact agatgggaca tacatatata   1544

 tagagagagt gagagagtcg tgtttcgtaa gtgcctgagc ttaggaagtt ttcttctgga   1604

 tatataacat tgcacaaggg aagacgagtg tggaggatag gttaagaaag gaaagggaca   1664

 gaagtcttgc aataggctgc agacatttta ataccatgcc agagaagagt attctgctga   1724

 aaccaacagg ttttactggt caaaatgact gctgaaaata attttcaagt tgaaagatct   1784

 agttttatct tagtttgcct tctttgtaca gacatgccaa gaggtgacat ttagcagtgc   1844

 attggtataa gcaattattt catcagttct cagattaaca agcatttctg ctctgcctgc   1904

 aggcccccag gcactttttt ttttggatgg ctcaaaatat ggtgctgctt tatataaacc   1964

 ttacatttat atagtgcacc tatgagcagt tgcctaccat gtgtccacca gaggctattt   2024

 aattcatgcc aacttgaaaa ctctccagtt tgtaggagtt tggtttaatt tattcagttt   2084

 cattaggact atttttatat atttatcctc ttcattttct cctaatgatg caacatctat   2144

 tcttgtcacc ctttgggaga agttacattt ctggaggtga tgaagcaagg agggagcact   2204

 aggaagagaa aagctacaat ttttaaagct ctttgtcaag ttagtgattg catttgatcc   2264

 caaaacaaga tgaatgtatg caatgggatg tacataagtt atttttgccc atgcctaaac   2324

 tagtgctatg taatggggtt gtggttttgt ttttttcgat ttcgtttaat gacaaaataa   2384

 tctcttaata tgctgaaatc aagcacgtga gagtttttgt ttaaaagata agagacacag   2444

 catgtattat gcacttcatt tctctactgt gtggagaaag caataaacat tatgagaatg   2504

 ttaaacgtta tgcaaaatta tacttttaaa tatttgtttt gaaattactg tacctagtct   2564

 tttttgcatt actttgtaac ctttttctat gcaagagtct ttacatacca ctaattaaat   2624

 gaagtccttt ttgactaaaa aaaaaaaa                                      2652




      <210> 306
      <211> 2938
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (569)..(1621)

      <400> 306
 ctttgcagct gagactgggt ggagggagag gcgcggagac actggggctc tgacgagctg     60

 gctgaggccc tctcagtagg ggggtcacgc ctcctggaac tcagggaccc caagtttctg    120

 tgcattcagg gcggggctgg ccccatgccc tgtgcatagg ggcctggctg catcccagtc    180

 gatcagccag aggcagcagc agtggactca tcaattgtgg aggaagccct ggggaccctg    240

 gggaccttgc cgactctatt cccagccagc tcctaggaca agcctcagag ccaacacccg    300

 ctcgaccctc tcccggcccc tccccttctt tgtcttttgc agatgatcgc cgggtgtcga    360

 tccttttccc tccagtcagg gccaggcgtg gacgccgccg gaccgctgag actcggggca    420

 cggtgaagca ctggccgggg tctggctggg tctggcgctc gggagccaga tggaggtggc    480

 gataggggcc gtgggagccg gcgccaagta gccggtggac ccccgcgctc gcaactctcc    540

 cggcgcccgg gcgctcccca aggctgcc   atg gag gtg cct aac gtc aag gac     592
                                  Met Glu Val Pro Asn Val Lys Asp
                                    1               5

 ttc cag tgg aag cgc ctg gcg cca ctg ccc agc cgc cgg gtc tac tgc      640
 Phe Gln Trp Lys Arg Leu Ala Pro Leu Pro Ser Arg Arg Val Tyr Cys
      10                  15                  20

 tcc ctg ctg gag acc ggg ggc cag gtc tat gcc atc ggg gga tgt gac      688
 Ser Leu Leu Glu Thr Gly Gly Gln Val Tyr Ala Ile Gly Gly Cys Asp
  25                  30                  35                  40

 gac aac ggc gtc ccc atg gac tgc ttc gag gtc tac tcc ccg gag gcc      736
 Asp Asn Gly Val Pro Met Asp Cys Phe Glu Val Tyr Ser Pro Glu Ala
                  45                  50                  55

 gac cag tgg acc gcc ttg ccc cgg ctg ccc aca gcc cgg gcg ggg gtg      784
 Asp Gln Trp Thr Ala Leu Pro Arg Leu Pro Thr Ala Arg Ala Gly Val
              60                  65                  70

 gcc gtc acc gcc ctg ggg aag cgg atc atg gtg att ggg ggc gtg ggc      832
 Ala Val Thr Ala Leu Gly Lys Arg Ile Met Val Ile Gly Gly Val Gly
          75                  80                  85

 acc aat cag ctg ccc ctg aag gtc gtg gag atg tac aac atc gat gag      880
 Thr Asn Gln Leu Pro Leu Lys Val Val Glu Met Tyr Asn Ile Asp Glu
      90                  95                 100

 ggc aag tgg aag aag agg agc atg ctg cgt gag gcc gcc atg ggc att      928
 Gly Lys Trp Lys Lys Arg Ser Met Leu Arg Glu Ala Ala Met Gly Ile
 105                 110                 115                 120

 tct gtc acg gcc aaa gat tac cga gta tat gcg gca ggc ggg atg ggc      976
 Ser Val Thr Ala Lys Asp Tyr Arg Val Tyr Ala Ala Gly Gly Met Gly
                 125                 130                 135

 ctg gac cta cgt cca cac aac cac ctc caa cac tat gac atg ctg aag     1024
 Leu Asp Leu Arg Pro His Asn His Leu Gln His Tyr Asp Met Leu Lys
             140                 145                 150

 gac atg tgg gtg tcc cta gca ccc atg ccc acc ccg aga tat gct gcc     1072
 Asp Met Trp Val Ser Leu Ala Pro Met Pro Thr Pro Arg Tyr Ala Ala
         155                 160                 165

 acc tcc ttc ctc cga ggc tcc aag atc tac gtg ctg ggg gga cga cag     1120
 Thr Ser Phe Leu Arg Gly Ser Lys Ile Tyr Val Leu Gly Gly Arg Gln
     170                 175                 180

 tcc aag tac gcg gtc aac gct ttc gag gtc ttt gac atc gag act cgc     1168
 Ser Lys Tyr Ala Val Asn Ala Phe Glu Val Phe Asp Ile Glu Thr Arg
 185                 190                 195                 200

 tcc tgg acc aag ttt ccc aac att ccc tat aag cgg gcc ttc tcc agc     1216
 Ser Trp Thr Lys Phe Pro Asn Ile Pro Tyr Lys Arg Ala Phe Ser Ser
                 205                 210                 215

 ttt gtg acc ctg gac aac cac ttg tac agc cta gga ggc ctg cgg caa     1264
 Phe Val Thr Leu Asp Asn His Leu Tyr Ser Leu Gly Gly Leu Arg Gln
             220                 225                 230

 ggt cgc ctc tac cgg cag ccc aag ttc ctg cgg acg atg gac gtg ttc     1312
 Gly Arg Leu Tyr Arg Gln Pro Lys Phe Leu Arg Thr Met Asp Val Phe
         235                 240                 245

 gac atg gaa cag ggg gga tgg ctg aag atg gaa cga tcg ttc ttc ctc     1360
 Asp Met Glu Gln Gly Gly Trp Leu Lys Met Glu Arg Ser Phe Phe Leu
     250                 255                 260

 aag aag cgg cgg gca gat ttt gtg gct ggc tct ctg agt gga cgg gtc     1408
 Lys Lys Arg Arg Ala Asp Phe Val Ala Gly Ser Leu Ser Gly Arg Val
 265                 270                 275                 280

 ata gtg gct ggg gga ctt ggg aat caa ccc act gtc ctg gag acg gcg     1456
 Ile Val Ala Gly Gly Leu Gly Asn Gln Pro Thr Val Leu Glu Thr Ala
                 285                 290                 295

 gaa gca ttc cac cca ggg aag aac aaa tgg gag atc ctc cct gcc atg     1504
 Glu Ala Phe His Pro Gly Lys Asn Lys Trp Glu Ile Leu Pro Ala Met
             300                 305                 310

 ccc aca ccc cgc tgt gcc tgc tcc agc ata gtc gtc aag aac tgc ctc     1552
 Pro Thr Pro Arg Cys Ala Cys Ser Ser Ile Val Val Lys Asn Cys Leu
         315                 320                 325

 ctc gct gtg gga ggt gtc aac cag ggt ctg agt gac gca gtg gag gcc     1600
 Leu Ala Val Gly Gly Val Asn Gln Gly Leu Ser Asp Ala Val Glu Ala
     330                 335                 340

 ctg tgt gtc tct gac tcc tag ct gtctctgggc tcagtacctt tgccctggac     1653
 Leu Cys Val Ser Asp Ser 
 345                 350

 catatcactt cactcttaac atgaggaatg atcttgtcca agcagtcggg gctacttcca   1713

 agaatgtcag ctcctgttag caaccagtgg agtctggcct tggggctcta agttgacctc   1773

 tctatagctc caaatcctac caatctcaga aaactgtaag aggcacagat gactccacca   1833

 gctgcagagc tgactctgaa gagagtcttc acttactgca caggcaaaga aaggcacagg   1893

 aatatttcct acctctccct cctgtgagtc ccacctcccc ccacccccat ctccaggagg   1953

 caggtagagc agttctgacc gagaggatag actgctgttg ctgtctttcc ccagctctga   2013

 actagtttta aggtagctta ggatgaaaaa tggagaatga ttgggggttc caaaccactt   2073

 tcttctccct tggcttatat ctcttcacca tttggtggtc aactgtgggc ctaccctgga   2133

 cctcatctac tcagcgagaa ttggacatga agctagaggc agctgccttg gaagggaagt   2193

 caggctcact tggacagccc aggccatggc aggaagaatc ccttcctctt ggggtccttg   2253

 atgggcatgt gtgatgggga aggagcagtc tcccagccct gggtctgctc cccacatctc   2313

 tcctaattcc acttcacctt ttgccacccc ctccccacca gaggcctagc ccttttgtca   2373

 ccgaaggccc ccagagtgtt tctgtgtgaa accctctcat ttacactgtg gcatcaaaat   2433

 ccacaaaaga tggattaatt gcactctggt taatagcagc agcacaatga ttaaaatcta   2493

 tattcctatc ttctctagca ccctggtgtg gggatggggc ggaagggtgt cttgaggggc   2553

 agggaggacc ccataaaaca atccctcctg cattctcagg ctaaataggg cccccagtga   2613

 ctacctgttc ttggctgtcc cctctgaaga gctctgcctt ctcacagcca ccaccagttg   2673

 ccccactccc aggaaaacag cacatgttct tcttctcctg ccttgagact gcgtgttagt   2733

 cttccattca taactcatca gcagctcagt ccttcttatg tctagtctca gttcattcag   2793

 ccaaagctca tttttgtcct atccaaagta gaaagggttc ttttagaaaa cttgaagaat   2853

 gtgcctcctc ttagcatctg tttctgactc ccagttattt ttaaaataaa tgatgaataa   2913

 aatgcctgcc ctgaaaaaaa aaaaa                                         2938




      <210> 307
      <211> 564
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(497)

      <400> 307
 tttagctgaa ctgagctgaa atcctaaagg ccgcggagtc ggcggtgttg taggtagcgg     60

 taccttgagt ggcaacagaa ttcgattaaa ttaca   atg gga aac att ttt gaa     113
                                          Met Gly Asn Ile Phe Glu
                                            1               5

 aag ctc ttt aaa agt cta ctt ggg aaa aaa aag atg cgg att ctt ata      161
 Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys Lys Met Arg Ile Leu Ile
              10                  15                  20

 ttg agt ttg gat aca gct gga aaa acc acc atc ttg tat aaa ttg aag      209
 Leu Ser Leu Asp Thr Ala Gly Lys Thr Thr Ile Leu Tyr Lys Leu Lys
          25                  30                  35

 ctg ggg gag act gtg cct gcc gtc cct aca gta ggt ttc tgt gtg gag      257
 Leu Gly Glu Thr Val Pro Ala Val Pro Thr Val Gly Phe Cys Val Glu
      40                  45                  50

 aca gta gaa tat aaa aat aac acc ttc gct gtc tgg gat gtt ggc agc      305
 Thr Val Glu Tyr Lys Asn Asn Thr Phe Ala Val Trp Asp Val Gly Ser
  55                  60                  65                  70

 cac ttc aaa atc aga cct ctg tgg cag cat ttt ttc cag aac aca aaa      353
 His Phe Lys Ile Arg Pro Leu Trp Gln His Phe Phe Gln Asn Thr Lys
                  75                  80                  85

 gag cta tca gct tcc cag ttt gca caa ttc atc aag aaa tta tgc ggg      401
 Glu Leu Ser Ala Ser Gln Phe Ala Gln Phe Ile Lys Lys Leu Cys Gly
              90                  95                 100

 gtc acc ggc aca aat gat gag gca tct cct gga aag ctt aac ttc tta      449
 Val Thr Gly Thr Asn Asp Glu Ala Ser Pro Gly Lys Leu Asn Phe Leu
         105                 110                 115

 tcc atc cca tct ctt gga cag atg atg cca gtt aat tac ttt gaa taa      497
 Ser Ile Pro Ser Leu Gly Gln Met Met Pro Val Asn Tyr Phe Glu 
     120                 125                 130

 atatgggcaa aagcttatca ttatcaacaa atgagaagaa agaaacccta tgccaggtaa    557

 caccaaa                                                              564




      <210> 308
      <211> 1500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(847)

      <400> 308
 tatcaatgtc atcactggca tcctcaagga ttatcttcga gagttgccca ccccactcat     60

 cacccagccc ctgtataagg tggtactgga ggcc    atg gcc cgg gac ccc cca     112
                                          Met Ala Arg Asp Pro Pro
                                            1               5

 aac aga gtt ccc ccc acc act gag ggc acc cga ggg ctc ctc agc tgc      160
 Asn Arg Val Pro Pro Thr Thr Glu Gly Thr Arg Gly Leu Leu Ser Cys
              10                  15                  20

 ctg cca gat gtg gaa agg gcc acg ctg acg ctt ctc ctg gac cac ctg      208
 Leu Pro Asp Val Glu Arg Ala Thr Leu Thr Leu Leu Leu Asp His Leu
          25                  30                  35

 cgc ctc gtc tcc tcc ttc cat gcc tac aac cgc atg acc cca cag aac      256
 Arg Leu Val Ser Ser Phe His Ala Tyr Asn Arg Met Thr Pro Gln Asn
      40                  45                  50

 ttg gcc gtg tgc ttc ggg cct gtg ctg ctg ccg gca cgc cag gcg ccc      304
 Leu Ala Val Cys Phe Gly Pro Val Leu Leu Pro Ala Arg Gln Ala Pro
  55                  60                  65                  70

 aca agg cct cgt gcc cgc agc tcc ggc cca ggc ctt gcc agt gca gtg      352
 Thr Arg Pro Arg Ala Arg Ser Ser Gly Pro Gly Leu Ala Ser Ala Val
                  75                  80                  85

 gac ttc aag cac cac atc gag gtg ctg cac tac ctg ctg cag tct tgg      400
 Asp Phe Lys His His Ile Glu Val Leu His Tyr Leu Leu Gln Ser Trp
              90                  95                 100

 ccg ggt gag ttc atg ccc agg gcc tgc acc acc aat ctg agc cag ccc      448
 Pro Gly Glu Phe Met Pro Arg Ala Cys Thr Thr Asn Leu Ser Gln Pro
         105                 110                 115

 gcc tgc ccc gac aat ctc cgg acg tcg cgc ctt act tgc gac cca aac      496
 Ala Cys Pro Asp Asn Leu Arg Thr Ser Arg Leu Thr Cys Asp Pro Asn
     120                 125                 130

 gac agc cac ctc tgc acc tgc cgc tgg cag acc ccg aag tgg gtg act      544
 Asp Ser His Leu Cys Thr Cys Arg Trp Gln Thr Pro Lys Trp Val Thr
 135                 140                 145                 150

 cgg ccc cgc ggt cga gga ggc ccc gaa agc ccc ccg agc aac cgc tac      592
 Arg Pro Arg Gly Arg Gly Gly Pro Glu Ser Pro Pro Ser Asn Arg Tyr
                 155                 160                 165

 gcc ggc gac tgg agc gtt tgc ggg cgg gac ttc ctg ccc tgt ggg cgg      640
 Ala Gly Asp Trp Ser Val Cys Gly Arg Asp Phe Leu Pro Cys Gly Arg
             170                 175                 180

 gat ttc ctg tcc ggg cca gac tac gac cac gtg acg ggc agt gac agc      688
 Asp Phe Leu Ser Gly Pro Asp Tyr Asp His Val Thr Gly Ser Asp Ser
         185                 190                 195

 gag gac gag gac gag gag gtc ggc gag ccg agg gtc acc ggt gac ttc      736
 Glu Asp Glu Asp Glu Glu Val Gly Glu Pro Arg Val Thr Gly Asp Phe
     200                 205                 210

 gaa gac gac ttc gat gcg ccc ttc aac ccg cac ctg aat ctc aaa gac      784
 Glu Asp Asp Phe Asp Ala Pro Phe Asn Pro His Leu Asn Leu Lys Asp
 215                 220                 225                 230

 ttc gac gcc ctc atc ctg gat ctg gag aga gag ctc tcc aag caa atc      832
 Phe Asp Ala Leu Ile Leu Asp Leu Glu Arg Glu Leu Ser Lys Gln Ile
                 235                 240                 245

 aac gtg tgc ctc tga gccagatgac ggggtgggac cccggttagt aaggaccggg      887
 Asn Val Cys Leu 
             250

 cgcccagtgg ctaaggcggt gccctggtga ccaaggagag ccagacctgt tgctcaggcc    947

 gagctcctgg ttgccagcga gttaccacgg gaccagtcgc gtgtatggct gagactcatt   1007

 cccagtttcc agggcccggt atttggacac tagttgccaa gtctggggcc tggggatttt   1067

 agggaccagc ggttgtgacc atctttcctg aggcaccaag gggtttccct tttgtttgcc   1127

 aaaaagtctg gcctttccaa tccccatctc cttgcccccc ccttgccccc ccccccgaaa   1187

 aattgagcac ttaaacccct ccccttttgg agggggcccc ctgaagcgtc aggctggggg   1247

 cagtctggta cggaacatat ttattgcctc catgcatgtg tgtgtgtgtc tggtgaggac   1307

 tggtgtgcgt ggacacgtct caagcaggcg tgtggggctc tttcagggac cacagaggag   1367

 ggagcagttt gcagtgccca gccaccctga aatccccaat aatggtgcct cagtgggccc   1427

 cagagttcca gtgggagagt acggttccct cctgtctccc tcttcttttc cgcacctcca   1487

 tctttgtgga taa                                                      1500




      <210> 309
      <211> 1664
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (293)..(1540)

      <400> 309
 gctccggaat tcccgggtcg acgatttcgt tagacggaac tttccgcgtg gagatctttg     60

 gccaagagaa tgagcctcag ctctgttctg tgggctgcac tgagtttctc ggtgtgagct    120

 ggagaatgtg gaggctgtgg acccacgagg tcgaacatta ttgcatcttg ctgtttcctt    180

 gggacatttg gaatctgctc gagtcttact ccgacataaa gcagatgtga caaaagaaaa    240

 tcgccaggga tggacagttt tacatgaggc tgtgagcact ggcgatcctg ag    atg     295
                                                              Met
                                                                1

 gtg tac aca gtt ctc caa cat cga gac tac cac aac aca tcc atg gcc      343
 Val Tyr Thr Val Leu Gln His Arg Asp Tyr His Asn Thr Ser Met Ala
               5                  10                  15

 ctt gag gga gtt cct gag ctg ctc caa aaa att ctc gag gct ccg gat      391
 Leu Glu Gly Val Pro Glu Leu Leu Gln Lys Ile Leu Glu Ala Pro Asp
          20                  25                  30

 ttc tat gtg cag atg aaa tgg gaa ttc acc agc tgg gtg ccc ttg gtt      439
 Phe Tyr Val Gln Met Lys Trp Glu Phe Thr Ser Trp Val Pro Leu Val
      35                  40                  45

 tct aga ata tgc ccg aat gat gtc tgt cgc atc tgg aaa agt ggt gcc      487
 Ser Arg Ile Cys Pro Asn Asp Val Cys Arg Ile Trp Lys Ser Gly Ala
  50                  55                  60                  65

 aaa ctg cgc gtc gat atc aca ttg ctg gga ttt gaa aac atg agc tgg      535
 Lys Leu Arg Val Asp Ile Thr Leu Leu Gly Phe Glu Asn Met Ser Trp
                  70                  75                  80

 ata aga ggg agg cgt agt ttt ata ttt aag gga gaa gac aac tgg gcg      583
 Ile Arg Gly Arg Arg Ser Phe Ile Phe Lys Gly Glu Asp Asn Trp Ala
              85                  90                  95

 gag tta atg gaa gtc aac cat gat gac aaa gtg gtc acc acc gaa cgc      631
 Glu Leu Met Glu Val Asn His Asp Asp Lys Val Val Thr Thr Glu Arg
         100                 105                 110

 ttc gac ctt tcc caa gaa atg gag cgc ctc act ctg gac ttg atg aag      679
 Phe Asp Leu Ser Gln Glu Met Glu Arg Leu Thr Leu Asp Leu Met Lys
     115                 120                 125

 cca aaa agc agg gaa gtt gag cgg cgg ctc aca agc cct gtc att aac      727
 Pro Lys Ser Arg Glu Val Glu Arg Arg Leu Thr Ser Pro Val Ile Asn
 130                 135                 140                 145

 acc agc ctc gat act aaa aat att gct ttt gaa aga act aaa tcc gga      775
 Thr Ser Leu Asp Thr Lys Asn Ile Ala Phe Glu Arg Thr Lys Ser Gly
                 150                 155                 160

 ttc tgg ggc tgg agg aca gat aaa gca gaa gtt gtt aat ggt tac gaa      823
 Phe Trp Gly Trp Arg Thr Asp Lys Ala Glu Val Val Asn Gly Tyr Glu
             165                 170                 175

 gca aag gtt tac aca gta aac aat gtg aat gtg atc acc aaa ata cgc      871
 Ala Lys Val Tyr Thr Val Asn Asn Val Asn Val Ile Thr Lys Ile Arg
         180                 185                 190

 aca gaa cat ctg acc gag gag gaa aaa aag aga tat aaa gca gac agg      919
 Thr Glu His Leu Thr Glu Glu Glu Lys Lys Arg Tyr Lys Ala Asp Arg
     195                 200                 205

 aac ccg ctg gaa tct ttg ctg gga act gtg gaa cac caa ttt ggt gca      967
 Asn Pro Leu Glu Ser Leu Leu Gly Thr Val Glu His Gln Phe Gly Ala
 210                 215                 220                 225

 caa ggg gac ctc acc acg gaa tgt gct act gca aac aac ccc aca gcc     1015
 Gln Gly Asp Leu Thr Thr Glu Cys Ala Thr Ala Asn Asn Pro Thr Ala
                 230                 235                 240

 atc acg cct gat gag tac ttc aat gaa gag ttt gat ctg aaa gac agg     1063
 Ile Thr Pro Asp Glu Tyr Phe Asn Glu Glu Phe Asp Leu Lys Asp Arg
             245                 250                 255

 gac att gga agg ccg aaa gag ctg acg att aga aca cag aag ttt aaa     1111
 Asp Ile Gly Arg Pro Lys Glu Leu Thr Ile Arg Thr Gln Lys Phe Lys
         260                 265                 270

 gca atg ttg tgg atg tgt gaa gag ttt ccc ctc tct ctg gtg gag cag     1159
 Ala Met Leu Trp Met Cys Glu Glu Phe Pro Leu Ser Leu Val Glu Gln
     275                 280                 285

 gtc att ccc atc att gac cta atg gct cga acg agt gct cat ttt gca     1207
 Val Ile Pro Ile Ile Asp Leu Met Ala Arg Thr Ser Ala His Phe Ala
 290                 295                 300                 305

 aga ctg aga gat ttc atc aaa ttg gaa ttc cca cct gga ttt cct gtc     1255
 Arg Leu Arg Asp Phe Ile Lys Leu Glu Phe Pro Pro Gly Phe Pro Val
                 310                 315                 320

 aaa ata gaa att ccc ttg ttt cat gtc tta aat gca cgg att aca ttt     1303
 Lys Ile Glu Ile Pro Leu Phe His Val Leu Asn Ala Arg Ile Thr Phe
             325                 330                 335

 gga aat gtt aat ggc tgt agc act gcc gaa gaa tct gta tct caa aat     1351
 Gly Asn Val Asn Gly Cys Ser Thr Ala Glu Glu Ser Val Ser Gln Asn
         340                 345                 350

 gtg gaa ggg acc cag gct gat tca gct tcc cac atc aca aac ttt gag     1399
 Val Glu Gly Thr Gln Ala Asp Ser Ala Ser His Ile Thr Asn Phe Glu
     355                 360                 365

 gtt gat caa tct gtg ttt gaa att ccc gaa tct tac tat gtt caa gac     1447
 Val Asp Gln Ser Val Phe Glu Ile Pro Glu Ser Tyr Tyr Val Gln Asp
 370                 375                 380                 385

 aat ggc aga aat gtg cat ttg caa gat gaa gat tac gag ata atg cag     1495
 Asn Gly Arg Asn Val His Leu Gln Asp Glu Asp Tyr Glu Ile Met Gln
                 390                 395                 400

 ttt gcc atc cag caa gtc tta cag ctg tca ctc act gac aaa tag acc     1543
 Phe Ala Ile Gln Gln Val Leu Gln Leu Ser Leu Thr Asp Lys 
             405                 410                 415

 tttcagcctg tgagcctctg cacaaagcca gagcttgtgg gcttgcacca gatgctgtgt   1603

 caaccagagg ccctagggct aaaagccctg caccttgcgt gcattgcagc aggcaacaac   1663

 t                                                                   1664




      <210> 310
      <211> 1884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1232)

      <400> 310
 aatctgtggt ttttgctcaa aactcagtct atctggatgc gttgaattat agacag         56                                                                 
 atg tct ggc cgt gct gga aga aga ggt caa gac ctg atg gga gat gta      104
 Met Ser Gly Arg Ala Gly Arg Arg Gly Gln Asp Leu Met Gly Asp Val
   1               5                  10                  15

 tat ttc ttt gat att cca ttc ccc aaa ata gga aaa ctc ata aaa tcc      152
 Tyr Phe Phe Asp Ile Pro Phe Pro Lys Ile Gly Lys Leu Ile Lys Ser
              20                  25                  30

 aat gtt cct gag ctg aga gga cac ttc cct ctc agc ata acc ctg gtc      200
 Asn Val Pro Glu Leu Arg Gly His Phe Pro Leu Ser Ile Thr Leu Val
          35                  40                  45

 ctg cga ctc atg ctg ctg gct tcc aag gga gat gac cca gag gat gcc      248
 Leu Arg Leu Met Leu Leu Ala Ser Lys Gly Asp Asp Pro Glu Asp Ala
      50                  55                  60

 aag gca aag gtg cta tca gtg cta aag cat tca ttg ctg tcc ttc aag      296
 Lys Ala Lys Val Leu Ser Val Leu Lys His Ser Leu Leu Ser Phe Lys
  65                  70                  75                  80

 caa ccc aga gtc atg gac atg tta aaa ctt tac ttc ctg ttt tct ttg      344
 Gln Pro Arg Val Met Asp Met Leu Lys Leu Tyr Phe Leu Phe Ser Leu
                  85                  90                  95

 cag ttc ctg gtg aaa gag ggc tat tta gat caa gaa ggt aat cct atg      392
 Gln Phe Leu Val Lys Glu Gly Tyr Leu Asp Gln Glu Gly Asn Pro Met
             100                 105                 110

 ggg ttt gct gga ctt gta tca cat ttg cat tat cat gaa cct tct aat      440
 Gly Phe Ala Gly Leu Val Ser His Leu His Tyr His Glu Pro Ser Asn
         115                 120                 125

 ctt gtt ttt gtc agt ttt ctt gta aat gga ctc ttc cat gat ctc tgt      488
 Leu Val Phe Val Ser Phe Leu Val Asn Gly Leu Phe His Asp Leu Cys
     130                 135                 140

 cag cca acc agg aaa ggc tca aaa cat ttt tct caa gac gtt atg gaa      536
 Gln Pro Thr Arg Lys Gly Ser Lys His Phe Ser Gln Asp Val Met Glu
 145                 150                 155                 160

 aag cta gta tta gta ttg gca cat ctc ttt gga aga aga tat ttt cca      584
 Lys Leu Val Leu Val Leu Ala His Leu Phe Gly Arg Arg Tyr Phe Pro
                 165                 170                 175

 cca aag ttc caa gat gca cac ttc gag ttt tat caa tca aag gtg ttc      632
 Pro Lys Phe Gln Asp Ala His Phe Glu Phe Tyr Gln Ser Lys Val Phe
             180                 185                 190

 ctt gat gat ctc cct gag gat ttt agt gat gct tta gat gaa tat aac      680
 Leu Asp Asp Leu Pro Glu Asp Phe Ser Asp Ala Leu Asp Glu Tyr Asn
         195                 200                 205

 atg aaa att atg gag gac ttt acc act ttc cta cga att gtt tcc aaa      728
 Met Lys Ile Met Glu Asp Phe Thr Thr Phe Leu Arg Ile Val Ser Lys
     210                 215                 220

 ctg gct gat atg aat cag gaa tat caa ctc cca ttg tca aaa atc aaa      776
 Leu Ala Asp Met Asn Gln Glu Tyr Gln Leu Pro Leu Ser Lys Ile Lys
 225                 230                 235                 240

 ttc aca ggt aaa gaa tgt gaa gac tct caa ctc gta tct cat ttg atg      824
 Phe Thr Gly Lys Glu Cys Glu Asp Ser Gln Leu Val Ser His Leu Met
                 245                 250                 255

 agc tgc aag gaa gga aga gta gca att tca cca ttt gtt tgt ctg tct      872
 Ser Cys Lys Glu Gly Arg Val Ala Ile Ser Pro Phe Val Cys Leu Ser
             260                 265                 270

 ggg aac ttt gat gat gat ttg ctt cga cta gaa act cca aac cat gtt      920
 Gly Asn Phe Asp Asp Asp Leu Leu Arg Leu Glu Thr Pro Asn His Val
         275                 280                 285

 act cta ggc aca atc ggt gtc aat cgc tct cag gct cca gtg ctg ttg      968
 Thr Leu Gly Thr Ile Gly Val Asn Arg Ser Gln Ala Pro Val Leu Leu
     290                 295                 300

 tca cag aaa ttt gat aac cga gga agg aaa atg tcg ctt aat gcc tat     1016
 Ser Gln Lys Phe Asp Asn Arg Gly Arg Lys Met Ser Leu Asn Ala Tyr
 305                 310                 315                 320

 gca ctg gat ttc tac aaa cat ggt tcc ttg ata gga tta gtc cag gat     1064
 Ala Leu Asp Phe Tyr Lys His Gly Ser Leu Ile Gly Leu Val Gln Asp
                 325                 330                 335

 aac agg atg aat gaa gga gat gct tat tat ttg ttg aag gat ttt gca     1112
 Asn Arg Met Asn Glu Gly Asp Ala Tyr Tyr Leu Leu Lys Asp Phe Ala
             340                 345                 350

 ctc acc att aaa tct atc agt gtt tcc ttg cgt gag cta tgt gaa aat     1160
 Leu Thr Ile Lys Ser Ile Ser Val Ser Leu Arg Glu Leu Cys Glu Asn
         355                 360                 365

 gaa gac gac aac gtt gtc tta gcc ttt gaa caa ctg agt aca act ttt     1208
 Glu Asp Asp Asn Val Val Leu Ala Phe Glu Gln Leu Ser Thr Thr Phe
     370                 375                 380

 tgg gaa aag tta aac aaa gtc taa aaacaaagtc tatgcaaacc acttaaaaat    1262
 Trp Glu Lys Leu Asn Lys Val 
 385                 390

 aattccatag tagtttttca ggtcacgttt ttgattctta tgcttcttgc cagaaataca   1322

 ttatgataaa gtggaaatac attacgatga agtggaaaga gcaaacactt tggaatcaaa   1382

 cagagttgca atcaaacctg ccatgttctg tcatgaatac tcacaaatta tttagtatac   1442

 ctgaatcttg gtttcttttt ataactgagt aataatggtt acatctcagg tagtttgagg   1502

 attgactaaa aaaatgcgag aatgttgtat gtgactgaat aacaattttt actctgcgaa   1562

 gccaaagtaa atataatatt atcagtaact ttatccccag tgtcagtatt tataaaatgt   1622

 ttattaaggc tagaaaaaat gaatacaata tcctgaaggt gaaatatatt ctcttcaatt   1682

 agcataaata tgatttacat aagttagcta tacagctatt gagatagtac tttctagtaa   1742

 acttaaacta ctttttaaac atacattttg tgatgattta acaaaaatat agagaatgat   1802

 ttgctttatt gtaattgtat ataagtgact ggaaaagcac aaagaaataa agtgggttcg   1862

 atctgtttac aaaaaaaaaa aa                                            1884




      <210> 311
      <211> 743
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(699)

      <400> 311
 gcggtggaat tcgaaatcct aaaggccgcg gagtcggcgg tgttgtaggt agcggtacct     60

 tgagtggcaa cagaattcga ttaaattaca     atg gga aac att ttt gaa aag     111
                                      Met Gly Asn Ile Phe Glu Lys
                                        1               5

 ctc ttt aaa agt cta ctt ggg aaa aaa aag atg cgg att ctt ata ttg      159
 Leu Phe Lys Ser Leu Leu Gly Lys Lys Lys Met Arg Ile Leu Ile Leu
          10                  15                  20

 agt ttg gat aca gct gga aaa acc acc atc ttg tat aaa ttg aag ctg      207
 Ser Leu Asp Thr Ala Gly Lys Thr Thr Ile Leu Tyr Lys Leu Lys Leu
      25                  30                  35

 ggg gag act gtg cct gcc gtc cct aca gta ggt ttc tgt gtg gag aca      255
 Gly Glu Thr Val Pro Ala Val Pro Thr Val Gly Phe Cys Val Glu Thr
  40                  45                  50                  55

 gta gaa tat aaa aat aac acc ttc gct gtc tgg gat gtt ggc agc cac      303
 Val Glu Tyr Lys Asn Asn Thr Phe Ala Val Trp Asp Val Gly Ser His
                  60                  65                  70

 ttc aaa atc aga cct ctg tgg cag cat ttt ttc cag aac aca aaa gag      351
 Phe Lys Ile Arg Pro Leu Trp Gln His Phe Phe Gln Asn Thr Lys Glu
              75                  80                  85

 cta tca gct tcc cag ttt gca caa ttc atc aag aaa tta tgc ggg gtc      399
 Leu Ser Ala Ser Gln Phe Ala Gln Phe Ile Lys Lys Leu Cys Gly Val
          90                  95                 100

 act ggc aca aat gat gag gca tct cct gga aag ctt aac ttc tta tcc      447
 Thr Gly Thr Asn Asp Glu Ala Ser Pro Gly Lys Leu Asn Phe Leu Ser
     105                 110                 115

 atc cca tct ctt gga cag atg atg cca gtt aat tac ttt gaa tgc tcc      495
 Ile Pro Ser Leu Gly Gln Met Met Pro Val Asn Tyr Phe Glu Cys Ser
 120                 125                 130                 135

 tcc acc aag cca agg cca gac tcc tgc aat cat agg atg gca aca cca      543
 Ser Thr Lys Pro Arg Pro Asp Ser Cys Asn His Arg Met Ala Thr Pro
                 140                 145                 150

 cct cta aag cac aga act tca ggc ttt gct tcg gaa gtg gca cca tgg      591
 Pro Leu Lys His Arg Thr Ser Gly Phe Ala Ser Glu Val Ala Pro Trp
             155                 160                 165

 tct ctt cat ttt ccc ttt ctt caa ggt cag aaa act gaa gct gtt agg      639
 Ser Leu His Phe Pro Phe Leu Gln Gly Gln Lys Thr Glu Ala Val Arg
         170                 175                 180

 agt ttt agt gtt aag ttc ctt ccg agg atg tta att agg ctt caa act      687
 Ser Phe Ser Val Lys Phe Leu Pro Arg Met Leu Ile Arg Leu Gln Thr
     185                 190                 195

 gtt ttg ttc tga gaa ataaaaacta aactccagtc attcaagcta aaaaaaaaaa      742
 Val Leu Phe 
 200

 a                                                                    743




      <210> 312
      <211> 1557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(1021)

      <400> 312
 gcacgagtgc aactgcagca agaggtaggg ctcaggcgtt gggaattgca ccgacaggca     60

 gtcgcacaga aaggcacaca gatgtagtgg tgtgcatagc ccttgacagc gaataggtgt    120

 cactagttcc aggcgtctgc tgaaagattt ggaacagaag  atg atg gcc act ccg     175
                                              Met Met Ala Thr Pro
                                                1               5

 aac cag acc gcc tgt aat gca gag tca cca gtg gcc ctg gag gag gcc      223
 Asn Gln Thr Ala Cys Asn Ala Glu Ser Pro Val Ala Leu Glu Glu Ala
                  10                  15                  20

 aag acc tct ggt gcc ccg ggg agc ccc caa aca ccc cct gag cgt cat      271
 Lys Thr Ser Gly Ala Pro Gly Ser Pro Gln Thr Pro Pro Glu Arg His
              25                  30                  35

 gac tct ggt ggt tcc ctg ccc ctg aca ccg cgg atg gag agc cac tca      319
 Asp Ser Gly Gly Ser Leu Pro Leu Thr Pro Arg Met Glu Ser His Ser
          40                  45                  50

 gag gat gaa gat ctt gct ggg gct gtc ggt ggc ctg ggc tgg aac agt      367
 Glu Asp Glu Asp Leu Ala Gly Ala Val Gly Gly Leu Gly Trp Asn Ser
      55                  60                  65

 agg agt ccc cgg acc cag agc cca ggg ggc tgc tca gcg gag gct gtg      415
 Arg Ser Pro Arg Thr Gln Ser Pro Gly Gly Cys Ser Ala Glu Ala Val
  70                  75                  80                  85

 ctg gcc cgg aag aaa cac cgt cgg cgg cca tcg aag cgc aaa agg cac      463
 Leu Ala Arg Lys Lys His Arg Arg Arg Pro Ser Lys Arg Lys Arg His
                  90                  95                 100

 tgg cga ccc tac ctg gag ctg agc tgg gct gag aaa caa cag cgg gat      511
 Trp Arg Pro Tyr Leu Glu Leu Ser Trp Ala Glu Lys Gln Gln Arg Asp
             105                 110                 115

 gag agg cag agc cag agg gcc tcc cgg gtc cgc gaa gag atg ttc gcc      559
 Glu Arg Gln Ser Gln Arg Ala Ser Arg Val Arg Glu Glu Met Phe Ala
         120                 125                 130

 aaa ggc cag ccc gtg gcc ccc tac aac acc acc cag ttc ctg atg aat      607
 Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr Gln Phe Leu Met Asn
     135                 140                 145

 gac agg gac ccg gag gag ccc aac ttg gat gtg ccc cat ggg atc tcc      655
 Asp Arg Asp Pro Glu Glu Pro Asn Leu Asp Val Pro His Gly Ile Ser
 150                 155                 160                 165

 cac cca ggt tcc agt ggg gag agt gag gcc ggg gac agt gat ggg cgg      703
 His Pro Gly Ser Ser Gly Glu Ser Glu Ala Gly Asp Ser Asp Gly Arg
                 170                 175                 180

 ggc cga gcg cac ggt gag ttc cag cgg aag gac ttc tct gag act tac      751
 Gly Arg Ala His Gly Glu Phe Gln Arg Lys Asp Phe Ser Glu Thr Tyr
             185                 190                 195

 gaa cgc ttc cac acc gag agc ctg cag ggc cgc agc aag cag gag ctg      799
 Glu Arg Phe His Thr Glu Ser Leu Gln Gly Arg Ser Lys Gln Glu Leu
         200                 205                 210

 gtg cga gac tac ctg gag ctg gag aag cgg ctg tcg cag gcg gag gag      847
 Val Arg Asp Tyr Leu Glu Leu Glu Lys Arg Leu Ser Gln Ala Glu Glu
     215                 220                 225

 gag act agg agg ctg cag cag ctg cag gcg tgc acc ggc cag cag tcc      895
 Glu Thr Arg Arg Leu Gln Gln Leu Gln Ala Cys Thr Gly Gln Gln Ser
 230                 235                 240                 245

 tgc cgc cag gtg gag gag ctg gct gcc gag gtc cag agg ctc cgg acc      943
 Cys Arg Gln Val Glu Glu Leu Ala Ala Glu Val Gln Arg Leu Arg Thr
                 250                 255                 260

 gaa aac cag cgg ctt cgt cag gag aac cag atg tgg aac cga gag ggc      991
 Glu Asn Gln Arg Leu Arg Gln Glu Asn Gln Met Trp Asn Arg Glu Gly
             265                 270                 275

 tgc cgc tgt gat gag gag ccg ggt acc tag g ggtgcctccc agcctggtgg     1042
 Cys Arg Cys Asp Glu Glu Pro Gly Thr 
         280                 285

 acccaaggag aaggtcccat ttcgtgcaca ctcaggccag ctgggtctca aggaggcagg   1102

 tggcagatga aaaccaccgt caacaccctg tgcgccctga gaacagctaa atcggttcag   1162

 actcccacct caccgtttcc atagttggct cttttgtgtc atcttaccct ttacagagaa   1222

 attaaatggc cttggtggga ccaaatggga gtatctagga ttgatttcac tagggctgtt   1282

 gtgagaacca aaacatttgc cccagagagg tctgagtggg gtcccagtcc ctgctgcccc   1342

 aagcctggca ggacagcaga cctctggatg gggacctccc aaggtctccg ggatacctga   1402

 atcctgctct gtgggtgttg gagcaatcag actgcacaga aggttttcta ggtgggaggg   1462

 agttcagtca ggagccccca gtttcggcca gaaactgacg ctcaagatac cagatcgctg   1522

 tgaggagttg tgagctttcc ctggaggaga gaacg                              1557




      <210> 313
      <211> 1354
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (208)..(1122)

      <400> 313
 cctttgcgcg ccgggttaat gggcggtaat ttggtaccct tgggtgcact ttgttttgcc     60

 cctgttcatt tgaatgcaaa tgggtgaccc gggcccgact aggtgcttat taaattgcag    120

 ttttcccccc tgccttttcc ggaatgcaga cttagaggag agaggctgcg ccctggccca    180

 gcctggctcg gctcagctcc gcgcgcc    atg gca agc tcg gct tcc ctg gag     231
                                  Met Ala Ser Ser Ala Ser Leu Glu
                                    1               5

 acc atg gtg ccc ccg gcc tgc ccg cgc gcc gga gcg ttg ccg gcc act      279
 Thr Met Val Pro Pro Ala Cys Pro Arg Ala Gly Ala Leu Pro Ala Thr
      10                  15                  20

 tcc aag aca ctg gcc ttt tcc atc gag cgc atc atg gcc aag acg tcg      327
 Ser Lys Thr Leu Ala Phe Ser Ile Glu Arg Ile Met Ala Lys Thr Ser
  25                  30                  35                  40

 gag ccc cgt gcg ccc ttt gag ccc cgg cct gga gcg cta gag gcg gac      375
 Glu Pro Arg Ala Pro Phe Glu Pro Arg Pro Gly Ala Leu Glu Ala Asp
                  45                  50                  55

 ggc agc cag ggc aag aaa ctg ctc aac ctc tgc tcg ccg ctg ccc tgt      423
 Gly Ser Gln Gly Lys Lys Leu Leu Asn Leu Cys Ser Pro Leu Pro Cys
              60                  65                  70

 atg atc ccc ctc cag ccc cta ggc tac gag gtg ccg tca aag aca ctg      471
 Met Ile Pro Leu Gln Pro Leu Gly Tyr Glu Val Pro Ser Lys Thr Leu
          75                  80                  85

 ctc agt tac tcg gag ctc tgg aaa agc agc ctc cgg gcg ggc ggc ggc      519
 Leu Ser Tyr Ser Glu Leu Trp Lys Ser Ser Leu Arg Ala Gly Gly Gly
      90                  95                 100

 gga ggc ggc ggc ggc ggt ggc ggc ggc ggc ggc ggg ggg gcc cca gtg      567
 Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Val
 105                 110                 115                 120

 tgc ggc gcc agc ggc ttg tgc aaa acc aac tgt ggc gtg tgc tgc aag      615
 Cys Gly Ala Ser Gly Leu Cys Lys Thr Asn Cys Gly Val Cys Cys Lys
                 125                 130                 135

 gcc gag ctg ggc ctg gcg ccg tcc gcg ctg ccc gcg ggc agg gtc atc      663
 Ala Glu Leu Gly Leu Ala Pro Ser Ala Leu Pro Ala Gly Arg Val Ile
             140                 145                 150

 aag ccg cag gtc atc aac cag gct gtg ggg ctg ccg gcc agc ggc tcg      711
 Lys Pro Gln Val Ile Asn Gln Ala Val Gly Leu Pro Ala Ser Gly Ser
         155                 160                 165

 ctc tac tac ttc aac tac ctg gac tcg acc gcg tac ccg ccg tct gag      759
 Leu Tyr Tyr Phe Asn Tyr Leu Asp Ser Thr Ala Tyr Pro Pro Ser Glu
     170                 175                 180

 ctc ctc agc ggc cac ctc ttc ccg tct ggc ctc ctc aat gcg cag gcc      807
 Leu Leu Ser Gly His Leu Phe Pro Ser Gly Leu Leu Asn Ala Gln Ala
 185                 190                 195                 200

 ccc gcc gcc ctg gct gct cac ccc aag ctc ttt ctg ctg gag aac gcc      855
 Pro Ala Ala Leu Ala Ala His Pro Lys Leu Phe Leu Leu Glu Asn Ala
                 205                 210                 215

 aag ctg gcc ggc ctg gct gcg gac aag ttc ccc cac ccg gct ccc tat      903
 Lys Leu Ala Gly Leu Ala Ala Asp Lys Phe Pro His Pro Ala Pro Tyr
             220                 225                 230

 ccc cat aag gag cgc ttg ccg gcg ccg ctg gag cag gta ctg aag gaa      951
 Pro His Lys Glu Arg Leu Pro Ala Pro Leu Glu Gln Val Leu Lys Glu
         235                 240                 245

 aac tcg gcc ctg act gcc gag cgc gga ggc gtc aag ggc cac agc aag      999
 Asn Ser Ala Leu Thr Ala Glu Arg Gly Gly Val Lys Gly His Ser Lys
     250                 255                 260

 ctg cca gga ggc tcc gca gat ggc aag ccc aaa aac ttc acc tgc gag     1047
 Leu Pro Gly Gly Ser Ala Asp Gly Lys Pro Lys Asn Phe Thr Cys Glu
 265                 270                 275                 280

 gtg tgc ggc aag gtg ttt aac gct cac tat aat ctc acc cgc cac ttg     1095
 Val Cys Gly Lys Val Phe Asn Ala His Tyr Asn Leu Thr Arg His Leu
                 285                 290                 295

 cgg caa agg gtt ttg cag aaa ctt tga cttaa agaaacatgt gcgcaaactc     1147
 Arg Gln Arg Val Leu Gln Lys Leu 
             300

 cacgacagcg tgggccctgc tgccccctcc gcaaaggacc tgactaggac agtgcagagc   1207

 tgagagctac tgccttgccc ttccttccct ccctgtacca cctgaaaaca gatcacacat   1267

 ataaacttat ttctaaaatt aaaagaaaaa aaaaactata gcagagaggc taaaatctat   1327

 ttatcgaaac cagcatattt ttggaaa                                       1354




      <210> 314
      <211> 981
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (200)..(652)

      <400> 314
 gagccggggt gaatctggag gggccgggcc gagcccgggg gcgctttcgc acgcgaagca     60

 accgctagag caggacctgg tctcccaaga gcgggactac ttgttgatat ttgaggaggg    120

 aagtgtctta cctgagagcc tggctggaga agactgaggt ccaaggcttg aagcctaagt    180

 gattgcccca ggactgtgg atg atg gct gca gac atc ccg aga gtg acc act     232
                      Met Met Ala Ala Asp Ile Pro Arg Val Thr Thr
                        1               5                  10

 ccg ctg agc tcc ttg gtc cag gtg cct caa gag gaa gat aga cag gag      280
 Pro Leu Ser Ser Leu Val Gln Val Pro Gln Glu Glu Asp Arg Gln Glu
              15                  20                  25

 gag gag gtc acc acc atg atc ctg gag gat gac tcc tgg gtg caa gaa      328
 Glu Glu Val Thr Thr Met Ile Leu Glu Asp Asp Ser Trp Val Gln Glu
          30                  35                  40

 gct gtg ctg cag gag gat ggc cct gag tct gag ccc ttt ccc cag agt      376
 Ala Val Leu Gln Glu Asp Gly Pro Glu Ser Glu Pro Phe Pro Gln Ser
      45                  50                  55

 gct ggc aag ggc ggc ccc cag gag gag gtg acc agg gga cca cag ggt      424
 Ala Gly Lys Gly Gly Pro Gln Glu Glu Val Thr Arg Gly Pro Gln Gly
  60                  65                  70                  75

 gca ctc ggc cgc ctc cga gag ctc tgc cgg cgc tgg ctg aga cca gag      472
 Ala Leu Gly Arg Leu Arg Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu
                  80                  85                  90

 gta cac acc aag gag cag atg tta acc atg ctg cca aag gaa att cag      520
 Val His Thr Lys Glu Gln Met Leu Thr Met Leu Pro Lys Glu Ile Gln
              95                 100                 105

 gct tgg ctg caa gag cat cgg cct gaa agc agt gag gag gca gcg gcc      568
 Ala Trp Leu Gln Glu His Arg Pro Glu Ser Ser Glu Glu Ala Ala Ala
         110                 115                 120

 ctg gtg gaa gac ttg acc cag acc ctt cag gac agt gct gta gct gtc      616
 Leu Val Glu Asp Leu Thr Gln Thr Leu Gln Asp Ser Ala Val Ala Val
     125                 130                 135

 ttt gct tcc ctt ccg gtg gag gtg acc agt ttg taa tgaa cttctggatc      666
 Phe Ala Ser Leu Pro Val Glu Val Thr Ser Leu 
 140                 145                 150

 tccagtcaga tactatggag gagagagtga tggagggctg aggagaggcc tcaggttgtt    726

 atttggttgg ggaggcacag agcagaggtt caggtctcag caggtgtcag aggtgattac    786

 agcccttccc atccaccttg cagcaggggc tttgtgcctt tcatctttaa ctgggcacct    846

 gagatgggaa ccaatgggga ccatcccaga cacatgggtt tgtctgtccc tgacttctgc    906

 ctctgagatt gtctttgttg gtctttgttt aataaacgcc ccgaccttcc tcatgattgc    966

 aaaaaaaaaa aaaaa                                                     981




      <210> 315
      <211> 2209
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(1694)

      <400> 315
 taagcttgcg gccgcactga gagctttacg cccggaggcg tcggcgctgc cactggcccg     60

 cgacgggaac ggggcgaaaa ggcggcggca cc  atg ttc tcc ctc aag ccg ccc     113
                                      Met Phe Ser Leu Lys Pro Pro
                                        1               5

 aaa ccc acc ttc agg tcc tac ctc ctg cca ccg ccc cag act gac gat      161
 Lys Pro Thr Phe Arg Ser Tyr Leu Leu Pro Pro Pro Gln Thr Asp Asp
          10                  15                  20

 aag atc aat tcg gaa ccg aag att aaa aaa ctg gag cca gtc ctt ttg      209
 Lys Ile Asn Ser Glu Pro Lys Ile Lys Lys Leu Glu Pro Val Leu Leu
      25                  30                  35

 cca gga gaa att gtc gta aat gaa gtc aat ttt gtg aga aaa tgc att      257
 Pro Gly Glu Ile Val Val Asn Glu Val Asn Phe Val Arg Lys Cys Ile
  40                  45                  50                  55

 gca aca gac aca agc cag tac gat ttg tgg gga aag ctg ata tgc agt      305
 Ala Thr Asp Thr Ser Gln Tyr Asp Leu Trp Gly Lys Leu Ile Cys Ser
                  60                  65                  70

 aac ttc aaa atc tcc ttt att aca gat gac cca atg cca tta cag aaa      353
 Asn Phe Lys Ile Ser Phe Ile Thr Asp Asp Pro Met Pro Leu Gln Lys
              75                  80                  85

 ttc cat tac aga aac ctt ctt ctt ggt gaa cac gat gtc cct tta aca      401
 Phe His Tyr Arg Asn Leu Leu Leu Gly Glu His Asp Val Pro Leu Thr
          90                  95                 100

 tgt att gag caa att gtc aca gta aac gac cac aag agg aag cag aaa      449
 Cys Ile Glu Gln Ile Val Thr Val Asn Asp His Lys Arg Lys Gln Lys
     105                 110                 115

 gtc cta ggc ccc aac cag aaa ctg aaa ttt aat cca aca gag tta att      497
 Val Leu Gly Pro Asn Gln Lys Leu Lys Phe Asn Pro Thr Glu Leu Ile
 120                 125                 130                 135

 att tat tgt aaa gat ttc aga att gtc aga ttt cgc ttt gat gaa tca      545
 Ile Tyr Cys Lys Asp Phe Arg Ile Val Arg Phe Arg Phe Asp Glu Ser
                 140                 145                 150

 ggt ccc gaa agt gct aaa aag gta tgc ctt gca ata gct cat tat tcc      593
 Gly Pro Glu Ser Ala Lys Lys Val Cys Leu Ala Ile Ala His Tyr Ser
             155                 160                 165

 cag cca aca gac ctc cag cta ctc ttt gca ttt gaa tat gtt ggg aaa      641
 Gln Pro Thr Asp Leu Gln Leu Leu Phe Ala Phe Glu Tyr Val Gly Lys
         170                 175                 180

 aaa tac cac aat tca gca aac aaa att aat gga att ccc tca gga gat      689
 Lys Tyr His Asn Ser Ala Asn Lys Ile Asn Gly Ile Pro Ser Gly Asp
     185                 190                 195

 gga gga gga gga gga gga gga ggt aat gga gct ggt ggt ggc agc agc      737
 Gly Gly Gly Gly Gly Gly Gly Gly Asn Gly Ala Gly Gly Gly Ser Ser
 200                 205                 210                 215

 cag aaa act cca ctc ttt gaa act tac tcg gat tgg gac aga gaa atc      785
 Gln Lys Thr Pro Leu Phe Glu Thr Tyr Ser Asp Trp Asp Arg Glu Ile
                 220                 225                 230

 aag agg aca ggt gct tcc ggg tgg aga gtt tgt tct att aac gag ggt      833
 Lys Arg Thr Gly Ala Ser Gly Trp Arg Val Cys Ser Ile Asn Glu Gly
             235                 240                 245

 tac atg ata tcc act tgc ctt cca gaa tac att gta gtg cca agt tct      881
 Tyr Met Ile Ser Thr Cys Leu Pro Glu Tyr Ile Val Val Pro Ser Ser
         250                 255                 260

 tta gca gac caa gat cta aag atc ttt tcc cat tct ttt gtt ggg aga      929
 Leu Ala Asp Gln Asp Leu Lys Ile Phe Ser His Ser Phe Val Gly Arg
     265                 270                 275

 agg atg cca ctc tgg tgc tgg agc cac tct aac ggc agt gct ctt gtg      977
 Arg Met Pro Leu Trp Cys Trp Ser His Ser Asn Gly Ser Ala Leu Val
 280                 285                 290                 295

 cga atg gcc ctc atc aaa gac gtg ctg cag cag agg aag att gac cag     1025
 Arg Met Ala Leu Ile Lys Asp Val Leu Gln Gln Arg Lys Ile Asp Gln
                 300                 305                 310

 agg att tgt aat gca ata act aaa agt cac cca cag aga agt gat gtt     1073
 Arg Ile Cys Asn Ala Ile Thr Lys Ser His Pro Gln Arg Ser Asp Val
             315                 320                 325

 tac aaa tca gat ttg gat aag acc ttg cct aat att caa gaa gta caa     1121
 Tyr Lys Ser Asp Leu Asp Lys Thr Leu Pro Asn Ile Gln Glu Val Gln
         330                 335                 340

 gca gca ttt gta aaa ctg aag cag cta tgc gtt aat gag cct ttt gaa     1169
 Ala Ala Phe Val Lys Leu Lys Gln Leu Cys Val Asn Glu Pro Phe Glu
     345                 350                 355

 gaa act gaa gag aaa tgg tta tct tca ctg gaa aat act cga tgg tta     1217
 Glu Thr Glu Glu Lys Trp Leu Ser Ser Leu Glu Asn Thr Arg Trp Leu
 360                 365                 370                 375

 gaa tat gta agg gca ttc ctt aag cat tca gca gaa ctt gta tac atg     1265
 Glu Tyr Val Arg Ala Phe Leu Lys His Ser Ala Glu Leu Val Tyr Met
                 380                 385                 390

 cta gaa agc aaa cat ctc tct gta gtc cta caa gag gag gaa gga aga     1313
 Leu Glu Ser Lys His Leu Ser Val Val Leu Gln Glu Glu Glu Gly Arg
             395                 400                 405

 gac ttg agc tgt tgt gta gct tct ctt gtt caa gtg atg ctg gat ccc     1361
 Asp Leu Ser Cys Cys Val Ala Ser Leu Val Gln Val Met Leu Asp Pro
         410                 415                 420

 tat ttt agg aca att act gga ttt cag agt ctg ata cag aag gag tgg     1409
 Tyr Phe Arg Thr Ile Thr Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp
     425                 430                 435

 gtc atg gca gga tat cag ttt cta gac aga tgc aac cat cta aag aga     1457
 Val Met Ala Gly Tyr Gln Phe Leu Asp Arg Cys Asn His Leu Lys Arg
 440                 445                 450                 455

 tca gag aaa gag tct cct tta ttt ttg cta ttc ttg gat gcc acc tgg     1505
 Ser Glu Lys Glu Ser Pro Leu Phe Leu Leu Phe Leu Asp Ala Thr Trp
                 460                 465                 470

 cag ctg tta gaa caa tat cct gca gct ttt gag ttc tcc gaa acc tac     1553
 Gln Leu Leu Glu Gln Tyr Pro Ala Ala Phe Glu Phe Ser Glu Thr Tyr
             475                 480                 485

 ctg gca gtg ttg tat gac agc acc cgg atc tca ctg ttt ggc acc ttc     1601
 Leu Ala Val Leu Tyr Asp Ser Thr Arg Ile Ser Leu Phe Gly Thr Phe
         490                 495                 500

 ctg ttc aac tcc cct cac cag cga gtg aag caa agc acg gtc agt agg     1649
 Leu Phe Asn Ser Pro His Gln Arg Val Lys Gln Ser Thr Val Ser Arg
     505                 510                 515

 ata aaa agt tgt aca aaa caa gat tat ttt cct tca cga gtt tga agt     1697
 Ile Lys Ser Cys Thr Lys Gln Asp Tyr Phe Pro Ser Arg Val 
 520                 525                 530

 ttctggtcac aattcattga tgtagaggat ttatgactaa gcagggtctc aagccaaact   1757

 tgaaaccatt ctgaaccaaa gtgccatttc acccacctcg aaccaacaac agaagctgac   1817

 aaatgccgtg gagaccattg agggaaacag aaaggggcag ctcttgtgga ccttcaggaa   1877

 gcctttctag gaagaggatt gccctcatag tgagctccgg ggtcttcagc ctcagccgta   1937

 aggccctggg ctaggcagtg tgacctaggg agcgggaaac ctgagttctg gccctggtct   1997

 gggaaaagtg ctaggcccat gttccactca ggcttcagcc tgagagtcca ggttgctaac   2057

 ctgtaaaatg gatctgtcaa actaacactt atgcctttag tctcattgta tgaggtgtaa   2117

 cattttgtaa actgtgaatc attatgcaaa ttttcctaaa gacatatgaa ttattctgga   2177

 tttgttggta taaaagacaa aatacactgg tc                                 2209




      <210> 316
      <211> 7256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (359)..(5584)

      <400> 316
 gctgcctctc cttgtggtgg ccgcgtgcgt cctgcccgga gccggcggga catgcccgga     60

 gcgcgcgctg gagcggcgcg aggaggaggc gaacgtggtg ctcaccggga cggtggagga    120

 gatcctcaac gtggacccgg tgcagcacac gtactcctgc aaggttcggg tctggcggta    180

 cttgaagggc aaagacctgg tggcccggga gagcctgctg gacggcggca acaaggtggt    240

 gatcagcggc tttggagacc ccctcatctg tgacaaccag gtgtccactg gggacaccag    300

 gatcttcttt gtgaaccctg cacccccata cctgtggcca gcccacaaga acgagctg      358                                                                 
 atg ctc aac tcc agc ctc atg cgg atc acc ctg cgg aac ctg gag gag      406
 Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg Asn Leu Glu Glu
   1               5                  10                  15

 gtg gag ttc tgt gtg gaa gat aaa ccc ggg acc cac ttc act cca gtg      454
 Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His Phe Thr Pro Val
              20                  25                  30

 cct ccg acg cct cct gat gcg tgc cgg gga atg ctg tgc ggc ttc ggc      502
 Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu Cys Gly Phe Gly
          35                  40                  45

 gcc gtg tgc gag ccc aac gcg gag ggg ccg ggc cgg gcg tcc tgc gtc      550
 Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg Ala Ser Cys Val
      50                  55                  60

 tgc aag aag agc ccg tgc ccc agc gtg gtg gcg cct gtg tgt ggg tcg      598
 Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro Val Cys Gly Ser
  65                  70                  75                  80

 gac gcc tcc acc tac agc aac gaa tgc gag ctg cag cgg gcg cag tgc      646
 Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln Arg Ala Gln Cys
                  85                  90                  95

 agc cag cag cgc cgc atc cgc ctg ctc agc cgc ggg ccg tgc ggc tcg      694
 Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly Pro Cys Gly Ser
             100                 105                 110

 cgg gac ccc tgc tcc aac gtg acc tgc agc ttc ggc agc acc tgt gcg      742
 Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly Ser Thr Cys Ala
         115                 120                 125

 cgc tcg gcc gac ggg ctg acg gcc tcg tgc ctg tgc ccc gcg acc tgc      790
 Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys Pro Ala Thr Cys
     130                 135                 140

 cgt ggc gcc ccc gag ggg acc gtc tgc ggc agc gac ggc gcc gac tac      838
 Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp Gly Ala Asp Tyr
 145                 150                 155                 160

 ccc ggc gag tgc cag ctc ctg cgc cgc gcc tgc gcc cgc cag gag aat      886
 Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala Arg Gln Glu Asn
                 165                 170                 175

 gtc ttc aag aag ttc gac ggc cct tgt gac ccc tgt cag ggc gcc ctc      934
 Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys Gln Gly Ala Leu
             180                 185                 190

 cct gac ccg agc cgc agc tgc cgt gtg aac ccg cgc acg cgg cgc cct      982
 Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg Thr Arg Arg Pro
         195                 200                 205

 gag atg cgc cta cgg ccc gag agc tgc cct gcc cgg cag gcg cca gtg     1030
 Glu Met Arg Leu Arg Pro Glu Ser Cys Pro Ala Arg Gln Ala Pro Val
     210                 215                 220

 tgt ggg gac gac gga gtc acc tac gaa aac gac tgt gtc atg ggc cga     1078
 Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys Val Met Gly Arg
 225                 230                 235                 240

 tcg ggg gcc gcc cgg ggt ctc ctc ctg cag aaa gtg cgc tcc ggc cag     1126
 Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val Arg Ser Gly Gln
                 245                 250                 255

 tgc cag ggt cga gac cag tgc ccg gag ccc tgc cgg ttc aat gcc gtg     1174
 Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg Phe Asn Ala Val
             260                 265                 270

 tgc ctg tcc cgc cgt ggc cgt ccc cgc tgc tcc tgc gac cgc gtc acc     1222
 Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys Asp Arg Val Thr
         275                 280                 285

 tgt gac ggg gcc tac agg ccc gtg tgt gcc cag gac ggg cgc acg tat     1270
 Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp Gly Arg Thr Tyr
     290                 295                 300

 gac agt gat tgc tgg cgg cag cag gct gag tgc cgg cag cag cgt gcc     1318
 Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala
 305                 310                 315                 320

 atc ccc agc aag cac cag ggc ccg tgt gac cag gcc ccg tcc cca tgc     1366
 Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala Pro Ser Pro Cys
                 325                 330                 335

 ctc ggg gtg cag tgt gca ttt ggg gcg acg tgt gct gtg aag aac ggg     1414
 Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala Val Lys Asn Gly
             340                 345                 350

 cag gca gcg tgt gaa tgc ctg cag gcg tgc tcg agc ctc tac gat cct     1462
 Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser Leu Tyr Asp Pro
         355                 360                 365

 gtg tgc ggc agc gac ggc gtc aca tac ggc agc gcg tgc gag ctg gag     1510
 Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu Leu Glu
     370                 375                 380

 gcc acg gcc tgt acc ctc ggg cgg gag atc cag gtg gcg cgc aaa gga     1558
 Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val Ala Arg Lys Gly
 385                 390                 395                 400

 ccc tgt gac cgc tgc ggg cag tgc cgc ttt gga gcc ctg tgc gag gcc     1606
 Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala Leu Cys Glu Ala
                 405                 410                 415

 gag acc ggg cgc tgc gtg tgc ccc tct gaa tgc gtg gct ttg gcc cag     1654
 Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val Ala Leu Ala Gln
             420                 425                 430

 ccc gtg tgt ggc tcc gac ggg cac acg tac ccc agc gag tgc atg ctg     1702
 Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser Glu Cys Met Leu
         435                 440                 445

 cac gtg cac gcc tgc aca cac cag atc agc ctg cac gtg gcc tca gct     1750
 His Val His Ala Cys Thr His Gln Ile Ser Leu His Val Ala Ser Ala
     450                 455                 460

 gga ccc tgc gag acc tgt gga gat gcc gtg tgt gct ttt ggg gct gtg     1798
 Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala Phe Gly Ala Val
 465                 470                 475                 480

 tgc tcc gca ggg cag tgt gtg tgt ccc cgg tgt gag cac ccc ccg ccc     1846
 Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu His Pro Pro Pro
                 485                 490                 495

 ggc ccc gtg tgt ggc agc gac ggt gtc acc tac ggc agt gcc tgc gag     1894
 Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu
             500                 505                 510

 cta cgg gaa gcc gcc tgc ctc cag cag aca cag atc gag gag gcc cgg     1942
 Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile Glu Glu Ala Arg
         515                 520                 525

 gca ggg ccg tgc gag cag gcc gag tgc ggt tcc gga ggc tct ggc tct     1990
 Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly Gly Ser Gly Ser
     530                 535                 540

 ggg gag gac ggt gac tgt gag cag gag ctg tgc cgg cag cgc ggt ggc     2038
 Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg Gln Arg Gly Gly
 545                 550                 555                 560

 atc tgg gac gag gac tcg gag gac ggg ccg tgt gtc tgt gac ttc agc     2086
 Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val Cys Asp Phe Ser
                 565                 570                 575

 tgc cag agt gtc cca ggc agc ccg gtg tgc ggc tca gat ggg gtc acc     2134
 Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser Asp Gly Val Thr
             580                 585                 590

 tac agc acc gag tgt gag ctg aag aag gcc agg tgt gag tca cag cga     2182
 Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys Glu Ser Gln Arg
         595                 600                 605

 ggg ctc tac gta gcg gcc cag gga gcc tgc cga ggc ccc acc ttc gcc     2230
 Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly Pro Thr Phe Ala
     610                 615                 620

 ccg ctg ccg cct gtg gcc ccc tta cac tgt gcc cag acg ccc tac ggc     2278
 Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln Thr Pro Tyr Gly
 625                 630                 635                 640

 tgc tgc cag gac aat atc acc gca gcc cgg ggc gtg ggc ctg gct ggc     2326
 Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val Gly Leu Ala Gly
                 645                 650                 655

 tgc ccc agt gcc tgc cag tgc aac ccc cat ggc tct tac ggc ggc acc     2374
 Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser Tyr Gly Gly Thr
             660                 665                 670

 tgt gac cca gcc aca ggc cag tgc tcc tgc cgc cca ggt gtg ggg ggc     2422
 Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro Gly Val Gly Gly
         675                 680                 685

 ctc agg tgt gac cgc tgt gag cct ggc ttc tgg aac ttt cga ggc atc     2470
 Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn Phe Arg Gly Ile
     690                 695                 700

 gtc acc gat ggc cgg agt ggc tgt aca ccc tgc agc tgt gat ccc caa     2518
 Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser Cys Asp Pro Gln
 705                 710                 715                 720

 ggc gcc gtg cgg gat gac tgt gag cag atg acg ggg ctg tgc tcg tgt     2566
 Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly Leu Cys Ser Cys
                 725                 730                 735

 aag ccc ggg gtg gct gga ccc aag tgt ggg cag tgt cca gac ggc cgt     2614
 Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys Pro Asp Gly Arg
             740                 745                 750

 gcc ctg ggc ccc gcg ggc tgt gaa gct gac gct tct gcg cct gcg acc     2662
 Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser Ala Pro Ala Thr
         755                 760                 765

 tgt gcg gag atg cgc tgt gag ttc ggt gcg cgg tgc gtg gag gag tct     2710
 Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys Val Glu Glu Ser
     770                 775                 780

 ggc tca gcc cac tgt gtc tgc ccg atg ctc acc tgt cca gag gcc aac     2758
 Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys Pro Glu Ala Asn
 785                 790                 795                 800

 gct acc aag gtc tgt ggg tca gat gga gtc aca tac ggc aac gag tgt     2806
 Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Asn Glu Cys
                 805                 810                 815

 cag ctg aag acc atc gcc tgc cgc cag ggc ctg caa atc tct atc cag     2854
 Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln Ile Ser Ile Gln
             820                 825                 830

 agc ctg ggc ccg tgc cag gag gct gtt gct ccc agc act cac ccg aca     2902
 Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser Thr His Pro Thr
         835                 840                 845

 tct gcc tcc gtg act gtg acc acc cca ggg ctc ctc ctg agc cag gca     2950
 Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu Leu Ser Gln Ala
     850                 855                 860

 ctg ccg gcc ccc ccc ggc gcc ctc ccc ctg gct ccc agc agt acc gca     2998
 Leu Pro Ala Pro Pro Gly Ala Leu Pro Leu Ala Pro Ser Ser Thr Ala
 865                 870                 875                 880

 cac agc cag acc acc cct ccg ccc tca tcg cga cct cgg acc act gcc     3046
 His Ser Gln Thr Thr Pro Pro Pro Ser Ser Arg Pro Arg Thr Thr Ala
                 885                 890                 895

 agc gtc ccc agg acc acc gtg tgg ccc gtg ctg acg gtg ccc ccc acg     3094
 Ser Val Pro Arg Thr Thr Val Trp Pro Val Leu Thr Val Pro Pro Thr
             900                 905                 910

 gca ccc tcc cct gca ccc agc ctg gtg gcg tcc gcc ttt ggt gaa tct     3142
 Ala Pro Ser Pro Ala Pro Ser Leu Val Ala Ser Ala Phe Gly Glu Ser
         915                 920                 925

 ggc agc act gat gga agc agc gat gag gaa ctg agc ggg gac cag gag     3190
 Gly Ser Thr Asp Gly Ser Ser Asp Glu Glu Leu Ser Gly Asp Gln Glu
     930                 935                 940

 gcc agt ggg ggt ggc tct ggg ggg ctc gag ccc ttg gag ggc agc agc     3238
 Ala Ser Gly Gly Gly Ser Gly Gly Leu Glu Pro Leu Glu Gly Ser Ser
 945                 950                 955                 960

 gtg gcc acc cct ggg cca cct gtc gag agg gct tcc tgc tac aac tcc     3286
 Val Ala Thr Pro Gly Pro Pro Val Glu Arg Ala Ser Cys Tyr Asn Ser
                 965                 970                 975

 gcg ttg ggc tgc tgc tct gat ggg aag acg ccc tcg ctg gac gca gag     3334
 Ala Leu Gly Cys Cys Ser Asp Gly Lys Thr Pro Ser Leu Asp Ala Glu
             980                 985                 990

 ggc tcc aac tgc ccc gcc acc aag gtg ttc cag ggc gtc ctg gag ctg     3382
 Gly Ser Asn Cys Pro Ala Thr Lys Val Phe Gln Gly Val Leu Glu Leu
         995                1000                1005

 gag ggc gtc gag ggc cag gag ctg ttc tac acg ccc gag atg gct gac     3430
 Glu Gly Val Glu Gly Gln Glu Leu Phe Tyr Thr Pro Glu Met Ala Asp
    1010                1015                1020

 ccc aag tca gaa ctg ttc ggg gag aca gcc agg agc att gag agc acc     3478
 Pro Lys Ser Glu Leu Phe Gly Glu Thr Ala Arg Ser Ile Glu Ser Thr
1025                1030                1035                1040

 ctg gac gac ctc ttc cgg aat tca gac gtc aag aag gat ttc cgg agt     3526
 Leu Asp Asp Leu Phe Arg Asn Ser Asp Val Lys Lys Asp Phe Arg Ser
                1045                1050                1055

 gtc cgc ttg cgg gac ctg ggg ccc ggc aaa tcc gtc cgc gcc att gtg     3574
 Val Arg Leu Arg Asp Leu Gly Pro Gly Lys Ser Val Arg Ala Ile Val
            1060                1065                1070

 gat gtg cac ttt gac ccc acc aca gcc ttc agg gca ccc gac gtg gcc     3622
 Asp Val His Phe Asp Pro Thr Thr Ala Phe Arg Ala Pro Asp Val Ala
        1075                1080                1085

 cgg gcc ctg ctc cgg cag atc cag gtg tcc agg cgc cgg tcc ttg ggg     3670
 Arg Ala Leu Leu Arg Gln Ile Gln Val Ser Arg Arg Arg Ser Leu Gly
    1090                1095                1100

 gtg agg cgg ccg ctg cag gag cac gtg cga ttt atg gac ttt gac tgg     3718
 Val Arg Arg Pro Leu Gln Glu His Val Arg Phe Met Asp Phe Asp Trp
1105                1110                1115                1120

 ttt cct gcg ttt atc acg ggg gcc acg tca gga gcc att gct gcg gga     3766
 Phe Pro Ala Phe Ile Thr Gly Ala Thr Ser Gly Ala Ile Ala Ala Gly
                1125                1130                1135

 gcc acg gcc aga gcc acc act gca tcg cgc ctg ccg tcc tct gct gtg     3814
 Ala Thr Ala Arg Ala Thr Thr Ala Ser Arg Leu Pro Ser Ser Ala Val
            1140                1145                1150

 acc cct cgg gcc ccg cac ccc agt cac aca agc cag ccc gtt gcc aag     3862
 Thr Pro Arg Ala Pro His Pro Ser His Thr Ser Gln Pro Val Ala Lys
        1155                1160                1165

 acc acg gca gcc ccc acc aca cgt cgg ccc ccc acc act gcc ccc agc     3910
 Thr Thr Ala Ala Pro Thr Thr Arg Arg Pro Pro Thr Thr Ala Pro Ser
    1170                1175                1180

 cgt gtg ccc gga cgt cgg ccc ccg gcc ccc cag cag cct cca aag ccc     3958
 Arg Val Pro Gly Arg Arg Pro Pro Ala Pro Gln Gln Pro Pro Lys Pro
1185                1190                1195                1200

 tgt gac tca cag ccc tgc ttc cac ggg ggg acc tgc cag gac tgg gca     4006
 Cys Asp Ser Gln Pro Cys Phe His Gly Gly Thr Cys Gln Asp Trp Ala
                1205                1210                1215

 ttg ggc ggg ggc ttc acc tgc agc tgc ccg gca ggc agg gga ggc gcc     4054
 Leu Gly Gly Gly Phe Thr Cys Ser Cys Pro Ala Gly Arg Gly Gly Ala
            1220                1225                1230

 gtc tgt gag aag gtg ctt ggc gcc cct gtg ccg gcc ttc gag ggc cgc     4102
 Val Cys Glu Lys Val Leu Gly Ala Pro Val Pro Ala Phe Glu Gly Arg
        1235                1240                1245

 tcc ttc ctg gcc ttc ccc acc ctc cgc gcc tac cac acg ctg cgc ctg     4150
 Ser Phe Leu Ala Phe Pro Thr Leu Arg Ala Tyr His Thr Leu Arg Leu
    1250                1255                1260

 gca ctg gaa ttc cgg gcg ctg gag cct cag ggg ctg ctg ctg tac aat     4198
 Ala Leu Glu Phe Arg Ala Leu Glu Pro Gln Gly Leu Leu Leu Tyr Asn
1265                1270                1275                1280

 ggc aac gcc cgg ggc aag gac ttc ctg gca ttg gcg ctg cta gat ggc     4246
 Gly Asn Ala Arg Gly Lys Asp Phe Leu Ala Leu Ala Leu Leu Asp Gly
                1285                1290                1295

 cgc gtg cag ctc agg ttt gac aca ggt tcg ggg ccg gcg gtg ctg acc     4294
 Arg Val Gln Leu Arg Phe Asp Thr Gly Ser Gly Pro Ala Val Leu Thr
            1300                1305                1310

 agt gcc gtg ccg gta gag ccg ggc cag tgg cac cgc ctg gag ctg tcc     4342
 Ser Ala Val Pro Val Glu Pro Gly Gln Trp His Arg Leu Glu Leu Ser
        1315                1320                1325

 cgg cac tgg cgc cgg ggc acc ctc tcg gtg gat ggt gag acc cct gtt     4390
 Arg His Trp Arg Arg Gly Thr Leu Ser Val Asp Gly Glu Thr Pro Val
    1330                1335                1340

 ctg ggc gag agt ccc agt ggc acc gac ggc ctc aac ctg gac aca gac     4438
 Leu Gly Glu Ser Pro Ser Gly Thr Asp Gly Leu Asn Leu Asp Thr Asp
1345                1350                1355                1360

 ctc ttt gtg ggc ggc gta ccc gag gac cag gct gcc gtg gcg ctg gag     4486
 Leu Phe Val Gly Gly Val Pro Glu Asp Gln Ala Ala Val Ala Leu Glu
                1365                1370                1375

 cgg acc ttc gtg ggc gcc ggc ctg agg ggg tgc atc cgt ttg ctg gac     4534
 Arg Thr Phe Val Gly Ala Gly Leu Arg Gly Cys Ile Arg Leu Leu Asp
            1380                1385                1390

 gtc aac aac cag cgc ctg gag ctt ggc att ggg ccg ggg gct gcc acc     4582
 Val Asn Asn Gln Arg Leu Glu Leu Gly Ile Gly Pro Gly Ala Ala Thr
        1395                1400                1405

 cga ggc tct ggc gtg ggc gag tgc ggg gac cac ccc tgc ctg ccc aac     4630
 Arg Gly Ser Gly Val Gly Glu Cys Gly Asp His Pro Cys Leu Pro Asn
    1410                1415                1420

 ccc tgc cat ggc ggg gcc cca tgc cag aac ctg gag gct gga agg ttc     4678
 Pro Cys His Gly Gly Ala Pro Cys Gln Asn Leu Glu Ala Gly Arg Phe
1425                1430                1435                1440

 cat tgc cag tgc ccg ccc ggc cgc gtc gga cca acc tgt gcc gat gag     4726
 His Cys Gln Cys Pro Pro Gly Arg Val Gly Pro Thr Cys Ala Asp Glu
                1445                1450                1455

 aag agc ccc tgc cag ccc aac ccc tgc cat ggg gcg gcg ccc tgc cgt     4774
 Lys Ser Pro Cys Gln Pro Asn Pro Cys His Gly Ala Ala Pro Cys Arg
            1460                1465                1470

 gtg ctg ccc gag ggt ggt gct cag tgc gag tgc ccc ctg ggg cgt gag     4822
 Val Leu Pro Glu Gly Gly Ala Gln Cys Glu Cys Pro Leu Gly Arg Glu
        1475                1480                1485

 ggc acc ttc tgc cag aca gcc tcg ggg cag gac ggc tct ggg ccc ttc     4870
 Gly Thr Phe Cys Gln Thr Ala Ser Gly Gln Asp Gly Ser Gly Pro Phe
    1490                1495                1500

 ctg gct gac ttc aac ggc ttc tcc cac ctg gag ctg aga ggc ctg cac     4918
 Leu Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu Arg Gly Leu His
1505                1510                1515                1520

 acc ttt gca cgg gac ctg ggg gag aag atg gcg ctg gag gtt cgt gtt     4966
 Thr Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Val Arg Val
                1525                1530                1535

 cct ggc acg agg ccc cag cgg cct cct gct cta caa cgg gca gaa gac     5014
 Pro Gly Thr Arg Pro Gln Arg Pro Pro Ala Leu Gln Arg Ala Glu Asp
            1540                1545                1550

 gga cgg caa ggg gga ctt cgt gtc gct ggc act gcg gga ccg ccg cct     5062
 Gly Arg Gln Gly Gly Leu Arg Val Ala Gly Thr Ala Gly Pro Pro Pro
        1555                1560                1565

 gga gtt ccg cta cga cct ggg caa ggg ggc agc ggt cat cag gag cag     5110
 Gly Val Pro Leu Arg Pro Gly Gln Gly Gly Ser Gly His Gln Glu Gln
    1570                1575                1580

 gga gcc agt cac cct ggg agc ctg gac cag ggt ctc act gga gcg aaa     5158
 Gly Ala Ser His Pro Gly Ser Leu Asp Gln Gly Leu Thr Gly Ala Lys
1585                1590                1595                1600

 cgg ccg caa ggg tgc cct gcg tgt ggg cga cgg ccc ccg tgt gtt ggg     5206
 Arg Pro Gln Gly Cys Pro Ala Cys Gly Arg Arg Pro Pro Cys Val Gly
                1605                1610                1615

 gga gtc ccc gaa atc ccg caa ggt tcc gca cac cgt cct caa cct gaa     5254
 Gly Val Pro Glu Ile Pro Gln Gly Ser Ala His Arg Pro Gln Pro Glu
            1620                1625                1630

 gga gcc gct cta cgt agg ggg cgc tcc cga ctt cag caa gct ggc ccg     5302
 Gly Ala Ala Leu Arg Arg Gly Arg Ser Arg Leu Gln Gln Ala Gly Pro
        1635                1640                1645

 tgc tgc tgc cgt gtc ctc tgg ctt cga cgg tgc cat cca gct ggt ctc     5350
 Cys Cys Cys Arg Val Leu Trp Leu Arg Arg Cys His Pro Ala Gly Leu
    1650                1655                1660

 cct cgg agg ccg cca gct gct gac ccc gga gca cgt gct gcg gca ggt     5398
 Pro Arg Arg Pro Pro Ala Ala Asp Pro Gly Ala Arg Ala Ala Ala Gly
1665                1670                1675                1680

 gga cgt cac gtc ctt tgc agg tca ccc ctg cac ccg ggc ctc agg cca     5446
 Gly Arg His Val Leu Cys Arg Ser Pro Leu His Pro Gly Leu Arg Pro
                1685                1690                1695

 ccc ctg cct caa tgg ggc ctc ctg cgt ccc gag gga ggc tgc cta tgt     5494
 Pro Leu Pro Gln Trp Gly Leu Leu Arg Pro Glu Gly Gly Cys Leu Cys
            1700                1705                1710

 gtg cct gtg tcc cgg ggg att ctc agg acc gca ctg cga gaa ggg gct     5542
 Val Pro Val Ser Arg Gly Ile Leu Arg Thr Ala Leu Arg Glu Gly Ala
        1715                1720                1725

 ggt gga gaa gtc agc ggg gga cgt gga tac ctt ggc ctt tga cgggcgg     5591
 Gly Gly Glu Val Ser Gly Gly Arg Gly Tyr Leu Gly Leu 
    1730                1735                1740

 acctttgtcg agtacctcaa cgctgtgacc gagagcgaga aggcactgca gagcaaccac   5651

 tttgaactga gcctgcgcac tgaggccacg caggggctgg tgctctggag tggcaaggcc   5711

 acggagcggg cagactatgt ggcactggcc attgtggacg ggcacctgca actgagctac   5771

 aacctgggct cccagcccgt ggtgctgcgt tccaccgtgc ccgtcaacac caaccgctgg   5831

 ttgcgggtcg tggcacatag ggagcagagg gaaggttccc tgcaggtggg caatgaggcc   5891

 cctgtgaccg gctcctcccc gctgggcgcc acgcagctgg acactgatgg agccctgtgg   5951

 cttgggggcc tgccggagct gcccgtgggc ccagcactgc ccaaggccta cggcacaggc   6011

 tttgtgggct gcttgcggga tgtggtggtg ggccggcacc cgctgcacct gctggaggac   6071

 gccgtcacca agccagagct gcggccctgc cccaccccat gagctggcac cagagccccg   6131

 cgcccgctgt aattattttc tatttttgta aacttgttgc tttttgatat gattttcttg   6191

 cctgagtgtt ggccggaggg actgctggcc cggcctccct tccgtccagg cagccgtgct   6251

 gcagacagac ctagtgctga gggatggaca ggcgaggtgg cagcgtggag ggctcggcgt   6311

 ggatggcagc ctcaggacac acacccctgc ctcaaggtgc tgagcccccg ccttgcactg   6371

 cgcctgcccc acggtgtccc cgccgggaag cagccccggc tcctgaatca ccctcgctcc   6431

 gtcaggcggg actcgtgtcc cagagaggaa ggggctgctg aggtctgatg gggcccttcc   6491

 tccgggtgac cccacagggc ctttccaagc ccctatttga gctgctcctt cctgtgtgtg   6551

 ctctggaccc tgcctcggcc tcctgcgcca atactgtgac ttccaaacaa tgttactgct   6611

 gggcacagct ctgcgttgct cccgtgctgc ctgcgccagc cccaggctgc tgaggagcag   6671

 aggccagacc agggccgatc tgggtgtcct gaccctcagc tggccctgcc cagccaccct   6731

 ggacatgacc gtatccctct gccacacccc aggccctgcg aggggctatc gagaggagct   6791

 cactgtggga tggggttgac ctctgccgcc tgcctgggta tctgggcctg gccatggctg   6851

 tgttcttcat gtgttgattt tatttgaccc ctggagtggt gggtctcatc tttcccatct   6911

 cgcctgagag cggctgaggg ctgcctcact gcaaatcctc cccacagcgt cagtgaaagt   6971

 cgtccttgtc tcagaatgac caggggccag ccagtgtctg accaaggtca aggggcaggt   7031

 gcagaggtgg cagggatggc tccgaagcca gaaatgcctt aaactgcaac gtcccgtccc   7091

 ttccccaccc ccatcccatc cccaccccca gccccagccc agtcctccta ggagcaggac   7151

 ccgatgaagc gggcggcggt ggggctgggt gccgtgttac taactctagt atgtttctgt   7211

 gtcaatcgct gtgaaataaa gtctgaaaac tttaaaaaaa aaaaa                   7256




      <210> 317
      <211> 1378
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1222)

      <400> 317
 cggccgcgcc aagcacacgg tatgggtgta gactggaccc gccccctaaa tccaggagac     60

 catcaactat ggaaaggaga tctagggaac accgtcttga acccgccagg ggttttgagt    120

 ctcggaccca ggagatccaa ccctgaccac cctcccagga tgcagcaggg gg    atg     175
                                                              Met
                                                                1

 tta aat cag act tca gga aga act tcc ttg ctg cct gag tta ggt gtc      223
 Leu Asn Gln Thr Ser Gly Arg Thr Ser Leu Leu Pro Glu Leu Gly Val
               5                  10                  15

 gtc acg cct gcc cag ggg cca agg agg cgg gtt tgg tgc ggc cac tcc      271
 Val Thr Pro Ala Gln Gly Pro Arg Arg Arg Val Trp Cys Gly His Ser
          20                  25                  30

 aag gcc aaa gcg aga aaa tct tac tgc gca cgc gca atg aga cag ccg      319
 Lys Ala Lys Ala Arg Lys Ser Tyr Cys Ala Arg Ala Met Arg Gln Pro
      35                  40                  45

 atg gag cca ccg atg gag ccg tcc gga ggg gag caa gag ccc gga gcc      367
 Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala
  50                  55                  60                  65

 gtc agg ttc ctg gac ctg ccc tgg gaa gac gtg ctg ctc cca cac gtc      415
 Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val
                  70                  75                  80

 ctg aac cgg gtc ccg ctg cgc cac gtg ctc cgg ctg cag cgc gtt acg      463
 Leu Asn Arg Val Pro Leu Arg His Val Leu Arg Leu Gln Arg Val Thr
              85                  90                  95

 cgg gcc ttc cgg tcg ctg gtg cag ctt cac ctg gcc ggg ctg cgt cgc      511
 Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg
         100                 105                 110

 ttc gat gcc gcg cag gtg ggt ccg cag atc ccg cgg gcc gca ttg gcc      559
 Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala
     115                 120                 125

 cgg ctg ctg cgg gat gcc gag ggg ctg cag gag ctg gca ctg gcg ccg      607
 Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro
 130                 135                 140                 145

 tgt cac gaa tgg ctg tca gac gag gac ctg gtg ccg gtg ctg gcg cgg      655
 Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg
                 150                 155                 160

 aat ccg cag ctg cgg agt gtg gcg ttg ggc ggc tgc ggg caa ctg agt      703
 Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser
             165                 170                 175

 cgc cgg gcg ctt ggg gct ttg gcc gag ggc tgc cca cgc ctg cag cgc      751
 Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg
         180                 185                 190

 ctg tcg ctc gcg cac tgt gac tgg gtg gac ggg ctg gcg ctg cgc ggc      799
 Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly
     195                 200                 205

 ctc gct gat cgc tgc ccg gcc ctg gag gag ctg gat ctc acc gcc tgc      847
 Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys
 210                 215                 220                 225

 cgc cag ctc aag gac gag gcc atc gtg tac ctg gcg cag agg cgc ggc      895
 Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg Gly
                 230                 235                 240

 gct ggt ctc cgc agc ctc tct ctg gcc gtc aac gcc aac gtg ggg gac      943
 Ala Gly Leu Arg Ser Leu Ser Leu Ala Val Asn Ala Asn Val Gly Asp
             245                 250                 255

 gcc gcg gtt caa gag ttg gct cgg aac tgc cca gaa ctc cac cac ctt      991
 Ala Ala Val Gln Glu Leu Ala Arg Asn Cys Pro Glu Leu His His Leu
         260                 265                 270

 gac ctc acc ggc tgc ctc cgc gtc gga agc gac ggt gtc agg aca ttg     1039
 Asp Leu Thr Gly Cys Leu Arg Val Gly Ser Asp Gly Val Arg Thr Leu
     275                 280                 285

 gcc gag tac tgc ccc gtg ctg cgt tcg ctg cgg gtg cgg cac tgc cac     1087
 Ala Glu Tyr Cys Pro Val Leu Arg Ser Leu Arg Val Arg His Cys His
 290                 295                 300                 305

 cat gtg gcg gag tcc agc ctg agc cgc ttg cgg aag cgc ggc gtg gac     1135
 His Val Ala Glu Ser Ser Leu Ser Arg Leu Arg Lys Arg Gly Val Asp
                 310                 315                 320

 atc gac gtg gag ccg ccg ctg cac cag gcc ctg gtg ctg ctg cag gat     1183
 Ile Asp Val Glu Pro Pro Leu His Gln Ala Leu Val Leu Leu Gln Asp
             325                 330                 335

 atg gcg ggc ttc gca cct ttt gtc aac ctg cag gtc tga cccgcctgcc      1232
 Met Ala Gly Phe Ala Pro Phe Val Asn Leu Gln Val 
         340                 345

 aatcggagca cagctggact gtgtggctgg ggcctgacac tgagctgtag ggaaactgaa   1292

 ctgtgaggac ctctggtgag aggccagtgc cctgccccac cctggagctt caaataaaga   1352

 gctttttacc cccaaaaaaa aaaaaa                                        1378




      <210> 318
      <211> 1371
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(800)

      <400> 318
 gcacgagcgg acggctgggc tgctgctggg cggccgcggg gcagcggagg gcgccggcac     60

 tccggtcccc gccgctccgc gtccccgctg ctcctagccc ctgccgcgtc cccggcggag    120

 cgggc    atg gcg cca ccc gcg gcg cct ggc cgg gac cgt gtg ggc cgt     167
          Met Ala Pro Pro Ala Ala Pro Gly Arg Asp Arg Val Gly Arg
            1               5                  10

 gag gat gag gac ggc tgg gag acg cga ggg gac cgc aag gcc cgg aag      215
 Glu Asp Glu Asp Gly Trp Glu Thr Arg Gly Asp Arg Lys Ala Arg Lys
  15                  20                  25                  30

 ccc ctg gtg gag aag aag cgg cgc gcg cgg atc aac gag agc ctg cag      263
 Pro Leu Val Glu Lys Lys Arg Arg Ala Arg Ile Asn Glu Ser Leu Gln
                  35                  40                  45

 gag ctg cgg ctg ctg ctg gcg ggc gcc gag gtg cag gcc aag ctg gag      311
 Glu Leu Arg Leu Leu Leu Ala Gly Ala Glu Val Gln Ala Lys Leu Glu
              50                  55                  60

 aac gcc gaa gtg ctg gag ctg acg gtg cgg cgg gtc cag ggt gtg ctg      359
 Asn Ala Glu Val Leu Glu Leu Thr Val Arg Arg Val Gln Gly Val Leu
          65                  70                  75

 cgg ggc cgg gcg cgc gag cgc gag cag ctg cag gcg gaa gcg agc gag      407
 Arg Gly Arg Ala Arg Glu Arg Glu Gln Leu Gln Ala Glu Ala Ser Glu
      80                  85                  90

 cgc ttc gct gcc ggc tac atc cag tgc atg cac gag gtg cac acg ttc      455
 Arg Phe Ala Ala Gly Tyr Ile Gln Cys Met His Glu Val His Thr Phe
  95                 100                 105                 110

 gtg tcc acg tgc cag gcc atc gac gct acc gtc gct gcc gag ctc ctg      503
 Val Ser Thr Cys Gln Ala Ile Asp Ala Thr Val Ala Ala Glu Leu Leu
                 115                 120                 125

 aac cat ctg ctc gag tcc atg ccg ctg cgt gag ggc agc agc ttc cag      551
 Asn His Leu Leu Glu Ser Met Pro Leu Arg Glu Gly Ser Ser Phe Gln
             130                 135                 140

 gat ctg ctg ggg gac gcc ctg gcg ggg cca cct aga gcc cct gga cgg      599
 Asp Leu Leu Gly Asp Ala Leu Ala Gly Pro Pro Arg Ala Pro Gly Arg
         145                 150                 155

 agt ggc tgg cct gcg ggg ggc gct ccg gga tcc cca ata ccc agc ccc      647
 Ser Gly Trp Pro Ala Gly Gly Ala Pro Gly Ser Pro Ile Pro Ser Pro
     160                 165                 170

 ccg ggt cct ggg gac gac ctg tgc tcc gac ctg gag gag gcc cct gag      695
 Pro Gly Pro Gly Asp Asp Leu Cys Ser Asp Leu Glu Glu Ala Pro Glu
 175                 180                 185                 190

 gct gaa ctg agt cag gct cct gct gag ggg ccc gac ttg gtg ccc gca      743
 Ala Glu Leu Ser Gln Ala Pro Ala Glu Gly Pro Asp Leu Val Pro Ala
                 195                 200                 205

 gcc ctg ggc agc ctg acc aca gcc caa att gcc cgg agt gtc tgg agg      791
 Ala Leu Gly Ser Leu Thr Thr Ala Gln Ile Ala Arg Ser Val Trp Arg
             210                 215                 220

 cct tgg tga ccaatgc cagccagagt cctgcggggg tgggcccggc cctccctgga      847
 Pro Trp 


 tctcctccct cctcccaggg gttcagatgt ggtggggtag ggccctggaa gtctcccagg    907

 tcttccctcc ctcctctgat ggatggcttg cagggcagcc cctggtaacc agcccagtca    967

 ggccccagcc ccgtttctta agaaactttt agggaccctg cagctctgga gtgggtggag   1027

 ggagggagct acgggcagga ggaagaattt tgtagagctg ccagcgctct cccaggttca   1087

 cccacccagg cttcaccagc cctgtgcggg ctctgggggc agaggtggca ggaatggtgc   1147

 tgggcactag tgttccaggc agccctgggc taaacaaaag cttgaacttg ccacttcagc   1207

 ggggagatga gaggcaggtg cactgagctg cactgcccag agctgtgatg ctctgtacat   1267

 cttgtttgta gcacacttga gtttgtgtat tccattgaca tcaaatgtga caattttact   1327

 aaataaagaa ttttggagtt agttaccctt gaaaaaaaaa aaaa                    1371




      <210> 319
      <211> 2394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(2279)

      <400> 319
 gtaggcgcag ggctggcaag cagtcgggac gggagcgcgg gcgtccgcgg tggctgcagt     60

 cccgtcggtc tccctgctgt ccggcgcgag ctcttcgagt cttgcttggt tggaagacca    120

 cagac    atg gaa ggg gcc cat gcc tcc ctt agc tta gag gac gaa gtc     167
          Met Glu Gly Ala His Ala Ser Leu Ser Leu Glu Asp Glu Val
            1               5                  10

 tct ggg gct ggc agc cgc caa cgc ccg cta gag ggg aag ggc ggc gag      215
 Ser Gly Ala Gly Ser Arg Gln Arg Pro Leu Glu Gly Lys Gly Gly Glu
  15                  20                  25                  30

 acc cct gct gcc gag gag ccg ggg tcc ctg aag aac tac gct gtc ttc      263
 Thr Pro Ala Ala Glu Glu Pro Gly Ser Leu Lys Asn Tyr Ala Val Phe
                  35                  40                  45

 gcc aca agg gat gtt tca gca gcc cct gag aag gaa gag gag gaa gct      311
 Ala Thr Arg Asp Val Ser Ala Ala Pro Glu Lys Glu Glu Glu Glu Ala
              50                  55                  60

 gag ggc ccg ctg agg gcg cag gac ctg agg gag tcc tac atc cag ctc      359
 Glu Gly Pro Leu Arg Ala Gln Asp Leu Arg Glu Ser Tyr Ile Gln Leu
          65                  70                  75

 gtc cag ggt gtg cag gag tgg cag gat ggt tgc atg tac cag ggg gag      407
 Val Gln Gly Val Gln Glu Trp Gln Asp Gly Cys Met Tyr Gln Gly Glu
      80                  85                  90

 ttt ggg ttg aac atg aag ctt gga tat ggc aaa ttc tct tgg ccc aca      455
 Phe Gly Leu Asn Met Lys Leu Gly Tyr Gly Lys Phe Ser Trp Pro Thr
  95                 100                 105                 110

 ggc gag tca tac cat ggg cag ttt tac cgg gac cac tgc cat ggc ctg      503
 Gly Glu Ser Tyr His Gly Gln Phe Tyr Arg Asp His Cys His Gly Leu
                 115                 120                 125

 ggt acc tac atg tgg cca gat ggc tcc agt ttc acg ggc aca ttt tac      551
 Gly Thr Tyr Met Trp Pro Asp Gly Ser Ser Phe Thr Gly Thr Phe Tyr
             130                 135                 140

 ctc agc cac cga gaa ggc tac ggc acc atg tac atg aag aca cgg ctt      599
 Leu Ser His Arg Glu Gly Tyr Gly Thr Met Tyr Met Lys Thr Arg Leu
         145                 150                 155

 ttc cag act cat tgc cac aac gac att gtc aac ctt ctc ctg gac tgt      647
 Phe Gln Thr His Cys His Asn Asp Ile Val Asn Leu Leu Leu Asp Cys
     160                 165                 170

 ggg gcc gac gtg aac aag tgc tca gat gag ggt ctc acg gca ctc agc      695
 Gly Ala Asp Val Asn Lys Cys Ser Asp Glu Gly Leu Thr Ala Leu Ser
 175                 180                 185                 190

 atg tgt ttc ctc ctc cac tac ccc gcc cag tcc ttc aag ccc aat gtt      743
 Met Cys Phe Leu Leu His Tyr Pro Ala Gln Ser Phe Lys Pro Asn Val
                 195                 200                 205

 gct gaa cgg acc ata cct gag ccc cag gaa cct cca aaa ttc cca gtt      791
 Ala Glu Arg Thr Ile Pro Glu Pro Gln Glu Pro Pro Lys Phe Pro Val
             210                 215                 220

 gtt cca atc ctt tca tca tca ttt atg gac aca aac ctg gag tct ctg      839
 Val Pro Ile Leu Ser Ser Ser Phe Met Asp Thr Asn Leu Glu Ser Leu
         225                 230                 235

 tac tat gag gtg aac gtg cct tcc cag ggt agc tat gag ctg agg cca      887
 Tyr Tyr Glu Val Asn Val Pro Ser Gln Gly Ser Tyr Glu Leu Arg Pro
     240                 245                 250

 ctg cca gca cca ctg ctc ctg cca cgc gtc tca ggc agc cac gag ggc      935
 Leu Pro Ala Pro Leu Leu Leu Pro Arg Val Ser Gly Ser His Glu Gly
 255                 260                 265                 270

 ggc cac ttc cag gac acc ggg cag tgt ggg ggg tcc ata gac cac agg      983
 Gly His Phe Gln Asp Thr Gly Gln Cys Gly Gly Ser Ile Asp His Arg
                 275                 280                 285

 agc agc tct ctg aag ggg gac tcc ccg ttg gtg aag ggc agc ctt ggc     1031
 Ser Ser Ser Leu Lys Gly Asp Ser Pro Leu Val Lys Gly Ser Leu Gly
             290                 295                 300

 cat gtg gaa agc ggg ctt gag gac gtg ttg gga aac aca gac cgg ggc     1079
 His Val Glu Ser Gly Leu Glu Asp Val Leu Gly Asn Thr Asp Arg Gly
         305                 310                 315

 agt ctg tgc agt gct gag acg aaa ttt gag tcc aac gtg tgt gtg tgc     1127
 Ser Leu Cys Ser Ala Glu Thr Lys Phe Glu Ser Asn Val Cys Val Cys
     320                 325                 330

 gac ttc tcc atc gag ctc tcg cag gcc atg ctg gag aga agc gcc cag     1175
 Asp Phe Ser Ile Glu Leu Ser Gln Ala Met Leu Glu Arg Ser Ala Gln
 335                 340                 345                 350

 tcc cac agc ttg ctg aag atg gcc tcg ccc tca ccg tgc acc agc agc     1223
 Ser His Ser Leu Leu Lys Met Ala Ser Pro Ser Pro Cys Thr Ser Ser
                 355                 360                 365

 ttc gac aaa ggg acc atg cgg agg atg gcg ctg tcc atg atc gag cgg     1271
 Phe Asp Lys Gly Thr Met Arg Arg Met Ala Leu Ser Met Ile Glu Arg
             370                 375                 380

 agg aag cgc tgg cgg acc atc gag ctg ctg ctg cgc cgg ggc gcg gac     1319
 Arg Lys Arg Trp Arg Thr Ile Glu Leu Leu Leu Arg Arg Gly Ala Asp
         385                 390                 395

 ccc aac ctg tgc tgc gtg ccc atg cag gtc ctg ttc ctt gct gtg aag     1367
 Pro Asn Leu Cys Cys Val Pro Met Gln Val Leu Phe Leu Ala Val Lys
     400                 405                 410

 gcc ggg gac gtg gat ggg gtg agg ctg ctg ctg gag cac ggg gcg agg     1415
 Ala Gly Asp Val Asp Gly Val Arg Leu Leu Leu Glu His Gly Ala Arg
 415                 420                 425                 430

 acc gac atc tgc ttt ccg ccg cag ctg agc acc ctg aca cca ctc cac     1463
 Thr Asp Ile Cys Phe Pro Pro Gln Leu Ser Thr Leu Thr Pro Leu His
                 435                 440                 445

 atc gct gcc gcc ctt cct ggg gag gag ggg gta cag att gtg gag ctg     1511
 Ile Ala Ala Ala Leu Pro Gly Glu Glu Gly Val Gln Ile Val Glu Leu
             450                 455                 460

 ctg ttg cat gcc atc acc gat gtg gac gcc aag gca tcc gac gag gac     1559
 Leu Leu His Ala Ile Thr Asp Val Asp Ala Lys Ala Ser Asp Glu Asp
         465                 470                 475

 gac act tac aag ccc ggc aag gtt gtg aag gag ctc ctg acc cag gga     1607
 Asp Thr Tyr Lys Pro Gly Lys Val Val Lys Glu Leu Leu Thr Gln Gly
     480                 485                 490

 gct gac ccc aac ctg ccc ctg acc aaa ggc ttg ggc agt gcc ctg tgt     1655
 Ala Asp Pro Asn Leu Pro Leu Thr Lys Gly Leu Gly Ser Ala Leu Cys
 495                 500                 505                 510

 gtt gcc tgt gac ctg acc tac gag cac cag agg aac atg gac agc aag     1703
 Val Ala Cys Asp Leu Thr Tyr Glu His Gln Arg Asn Met Asp Ser Lys
                 515                 520                 525

 ctg gcc ctg att gac cga ctc atc agt cac ggg gcc gac atc ctg aag     1751
 Leu Ala Leu Ile Asp Arg Leu Ile Ser His Gly Ala Asp Ile Leu Lys
             530                 535                 540

 cct gta atg ctc agg cag gga gaa aag gag gca gtg ggc aca gcc gtg     1799
 Pro Val Met Leu Arg Gln Gly Glu Lys Glu Ala Val Gly Thr Ala Val
         545                 550                 555

 gac tat ggc tac ttc aga ttc ttc cag gac cgg agg att gcc cgc tgc     1847
 Asp Tyr Gly Tyr Phe Arg Phe Phe Gln Asp Arg Arg Ile Ala Arg Cys
     560                 565                 570

 ccc ttc cac acg ctg atg cca gca gag cgc gag acg ttc ctg gcg cgg     1895
 Pro Phe His Thr Leu Met Pro Ala Glu Arg Glu Thr Phe Leu Ala Arg
 575                 580                 585                 590

 aag cgg ctc ctg gag tac atg ggc ttg cag cta cgg cag gct gtc ttt     1943
 Lys Arg Leu Leu Glu Tyr Met Gly Leu Gln Leu Arg Gln Ala Val Phe
                 595                 600                 605

 gcc aag gag agc cag tgg gac ccc acg tgg ctg tac ctg tgc aag aga     1991
 Ala Lys Glu Ser Gln Trp Asp Pro Thr Trp Leu Tyr Leu Cys Lys Arg
             610                 615                 620

 gcg gag ctg atc ccc agc cac agg atg aag aag aag ggc ccc agc ctg     2039
 Ala Glu Leu Ile Pro Ser His Arg Met Lys Lys Lys Gly Pro Ser Leu
         625                 630                 635

 ccc agg ggc ctg gat gtg aag gag cag ggg caa att ccc ttc ttc aag     2087
 Pro Arg Gly Leu Asp Val Lys Glu Gln Gly Gln Ile Pro Phe Phe Lys
     640                 645                 650

 ttc tgc tac cag tgt ggc cgc tcc atc ggg gtc cgc ctc ttg ccc tgc     2135
 Phe Cys Tyr Gln Cys Gly Arg Ser Ile Gly Val Arg Leu Leu Pro Cys
 655                 660                 665                 670

 cct cgc tgc tac ggg atc ctg acc tgc agc aag tac tgc aag acc aag     2183
 Pro Arg Cys Tyr Gly Ile Leu Thr Cys Ser Lys Tyr Cys Lys Thr Lys
                 675                 680                 685

 gcc tgg acc gag ttc cac aag aag gac tgc ggg gac ctg gtg gcc atc     2231
 Ala Trp Thr Glu Phe His Lys Lys Asp Cys Gly Asp Leu Val Ala Ile
             690                 695                 700

 gtg aca caa ctg gag caa gtt tcc agg agg aga gaa gaa ttc cag tga     2279
 Val Thr Gln Leu Glu Gln Val Ser Arg Arg Arg Glu Glu Phe Gln 
         705                 710                 715

 agcagcagct gcacgtccga ggcttgggga ggacccagga ctgtgtgggt ttcttacctg   2339

 cctgagccac ctcagggaat cttccagcct aatgcaggca ctcagaacaa cgaca        2394




      <210> 320
      <211> 1497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (584)..(1162)

      <400> 320
 aacacccatc gaggtcagga gtcactggaa aagttgttag gccggtattt ctacatctcg     60

 cctttgtcaa cccttgccaa aacggtgagg cagcggtgtg ttacctgctg acagcaagat    120

 gggagtcaag gtccagccgt tccgcccagc atacgagctt gtggagcagc cccctttgaa    180

 ggtctccagg tggacttcac ggagatgcca aagtgtggag gtaacaagca tgtactggtt    240

 cttgggcgta cctactctgg gtgggtggag gcctatccaa cacgaactga gaaagctggt    300

 gaagtaatcc ctgtgcttct tcgagatctg attcctagat ttcgactgcc cttacggatc    360

 ggctcacata acgggcctgc gtttttggct gccatggtac agaagacggc aaaggtattg    420

 gggatcacac ggaaactgca tgccgcctcc cagcctcaga gttccggaaa ggtgtccaag    480

 tcacacagag ccacggaatc tcacaggagc ctgagaactc ctcctcctgg gactctcaga    540

 ggatccagaa ctgcagccca tcctcgctgg gctgtccctg tcc  atg tat ctg gtc     595
                                                  Met Tyr Leu Val
                                                    1

 acg gtg ctg agg aac ctc ctc atc agc ctg gct gtc agc tct gac tcc      643
 Thr Val Leu Arg Asn Leu Leu Ile Ser Leu Ala Val Ser Ser Asp Ser
   5                  10                  15                  20

 cac ctc cac acc cca atg tgc ttc ttc ctc tcc aac ctg tgc tgg gct      691
 His Leu His Thr Pro Met Cys Phe Phe Leu Ser Asn Leu Cys Trp Ala
                  25                  30                  35

 gac atc ggt ttc acc tcg gcc acg gtt ccc aag atg att gtg gac atg      739
 Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys Met Ile Val Asp Met
              40                  45                  50

 cgg tcg cat agc gga gtc atc tct tat gcg gac tgc ctg aca cgg atg      787
 Arg Ser His Ser Gly Val Ile Ser Tyr Ala Asp Cys Leu Thr Arg Met
          55                  60                  65

 tct ttc ttg gtc ctt ttt gca tgt gta gaa gac atg ctc ctg act gtg      835
 Ser Phe Leu Val Leu Phe Ala Cys Val Glu Asp Met Leu Leu Thr Val
      70                  75                  80

 atg gcc tat gac tgt ttt gta gcc atc tgt cgc cct ctg cac tac cca      883
 Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg Pro Leu His Tyr Pro
  85                  90                  95                 100

 gtc atc gtg aat cct cac ctc tgt gtc ttc tta gtt tcg gtg tcc ttt      931
 Val Ile Val Asn Pro His Leu Cys Val Phe Leu Val Ser Val Ser Phe
                 105                 110                 115

 tcc tta gcc tgt tgg att ccc agc tgc gca gtt gga ttg tgt tgc aat      979
 Ser Leu Ala Cys Trp Ile Pro Ser Cys Ala Val Gly Leu Cys Cys Asn
             120                 125                 130

 tca cct tct tca aga atg tgg aaa tct cta att ttg tct gtg acc cat     1027
 Ser Pro Ser Ser Arg Met Trp Lys Ser Leu Ile Leu Ser Val Thr His
         135                 140                 145

 ctc aac ctc tca agc ttg cct gtt ctg aca gca tca tcg ata gca tgt     1075
 Leu Asn Leu Ser Ser Leu Pro Val Leu Thr Ala Ser Ser Ile Ala Cys
     150                 155                 160

 tca tat att tcg ata gta cta tgt ttg gtt ttc ttc gca ttt cag gga     1123
 Ser Tyr Ile Ser Ile Val Leu Cys Leu Val Phe Phe Ala Phe Gln Gly
 165                 170                 175                 180

 tcc ttt tgt ctt act ata aaa ttg tcc cct cca ttc taa ggatttcatc      1172
 Ser Phe Cys Leu Thr Ile Lys Leu Ser Pro Pro Phe 
                 185                 190

 gtcagatggg tagtataaag ccttctccgc ctgtggctct cacctgccag ttgtttgctt   1232

 attttatgga acaggcattg gcgtgtacct gacttcagct gtggcaccac ccctcaggaa   1292

 tggtgtggtg gcgtcagtga cgtatgctgt ggtcaccccc atgctgaacc ctttcatcta   1352

 cagcctgaga aacagggaca ttcaaagcgc cctgtggagg ctgcgcagca gaacagtcaa   1412

 atctcatgat ctgttccatc ctttttcttg tgtgggtaag aaagggcaag cacattaaat   1472

 ccctacatct gcaaaaaaaa aaaaa                                         1497




      <210> 321
      <211> 450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(326)

      <400> 321
 aggtcgagga acaaggtcgt gaaaaaaaaa ggtcttggtg aggtgccgcc atttcatctg     60

 tcctcattct ctgcgccttt cgcagagctt ccagcagcgg t    atg ttg ggc cag     113
                                                  Met Leu Gly Gln
                                                    1

 agc atc cgg agg ttc aca acc tct gtg gtc cgt agg agc cac tat gag      161
 Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg Ser His Tyr Glu
   5                  10                  15                  20

 gag ggc cct ggg aag aat ttg cca ttt tca gtg gaa aac aag tgg tcg      209
 Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu Asn Lys Trp Ser
                  25                  30                  35

 tta cta gct aag atg tgt ttg tac ttt gga tct gca ttt gct aca ccc      257
 Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala Phe Ala Thr Pro
              40                  45                  50

 ttc ctt gta gta aga cac caa ctg ctt aaa aca tca gga tgt ttc agt      305
 Phe Leu Val Val Arg His Gln Leu Leu Lys Thr Ser Gly Cys Phe Ser
          55                  60                  65

 tcc tcc ctt tca ccg ata tga ag agcattttta gaggtgcagc ctcatggagt      358
 Ser Ser Leu Ser Pro Ile 
      70

 ggatccaact aggacccata tgccatcccc gatatttttg ttatcaaact tctcccgtgt    418

 caataccggg ttttcctctt aaaaaaaaaa aa                                  450




      <210> 322
      <211> 2009
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1569)

      <400> 322
 gcggccgctg aattctaggt ggattactac aagcagcagt atgatattac tgtatcggac     60

 ctgaatcagc cc    atg ctt gtt agt ctg tta aag aag aag aga aat gac     108
                  Met Leu Val Ser Leu Leu Lys Lys Lys Arg Asn Asp
                    1               5                  10

 aac agt gag cct cag ctc gcc cac ctg ata cct gag ctc tgc ttt cta      156
 Asn Ser Glu Pro Gln Leu Ala His Leu Ile Pro Glu Leu Cys Phe Leu
          15                  20                  25

 aca ggg ctg act gac cag gca aca tct gat ttc cag ctg atg aag gct      204
 Thr Gly Leu Thr Asp Gln Ala Thr Ser Asp Phe Gln Leu Met Lys Ala
      30                  35                  40

 gtg gct gaa aag aca cgt ctc agt cct tca ggc cgg cag cag cgc ctg      252
 Val Ala Glu Lys Thr Arg Leu Ser Pro Ser Gly Arg Gln Gln Arg Leu
  45                  50                  55                  60

 gcc agg ctt gtg gac aac atc cag agg aat acc aat gct cgc ttt gaa      300
 Ala Arg Leu Val Asp Asn Ile Gln Arg Asn Thr Asn Ala Arg Phe Glu
                  65                  70                  75

 cta gag acc tgg gga ctg cat ttt gga agc cag ata tct ctg act ggc      348
 Leu Glu Thr Trp Gly Leu His Phe Gly Ser Gln Ile Ser Leu Thr Gly
              80                  85                  90

 cgg att gtg cct tca gaa aaa ata tta atg caa gac cac ata tgt caa      396
 Arg Ile Val Pro Ser Glu Lys Ile Leu Met Gln Asp His Ile Cys Gln
          95                 100                 105

 cct gtg tct gct gct gac tgg tcc aag gat att cga act tgc aag att      444
 Pro Val Ser Ala Ala Asp Trp Ser Lys Asp Ile Arg Thr Cys Lys Ile
     110                 115                 120

 tta aat gca cag tct ttg aat acc tgg ttg att tta tgt agc gac aga      492
 Leu Asn Ala Gln Ser Leu Asn Thr Trp Leu Ile Leu Cys Ser Asp Arg
 125                 130                 135                 140

 act gaa tat gtt gcc gag agc ttt ctg aac tgc ttg aga aga gtt gca      540
 Thr Glu Tyr Val Ala Glu Ser Phe Leu Asn Cys Leu Arg Arg Val Ala
                 145                 150                 155

 ggt tcc atg gga ttt aat gtg gac tac ccc aaa atc ata aaa gta caa      588
 Gly Ser Met Gly Phe Asn Val Asp Tyr Pro Lys Ile Ile Lys Val Gln
             160                 165                 170

 gaa aat cca gct gca ttt gtt aga gct ata cag caa tat gtt gat cct      636
 Glu Asn Pro Ala Ala Phe Val Arg Ala Ile Gln Gln Tyr Val Asp Pro
         175                 180                 185

 gat gtt cag ctg gta atg tgc att ctg cct tct aat cag aag acc tat      684
 Asp Val Gln Leu Val Met Cys Ile Leu Pro Ser Asn Gln Lys Thr Tyr
     190                 195                 200

 tat gat tcc att aaa aaa tat ttg agc tca gac tgc cca gtc cca agc      732
 Tyr Asp Ser Ile Lys Lys Tyr Leu Ser Ser Asp Cys Pro Val Pro Ser
 205                 210                 215                 220

 caa tgt gtg ctt gct cgg acc ttg aat aaa cag ggc atg atg atg agt      780
 Gln Cys Val Leu Ala Arg Thr Leu Asn Lys Gln Gly Met Met Met Ser
                 225                 230                 235

 atc gcc acc aag atc gct atg cag atg act tgc aag ctc gga ggc gag      828
 Ile Ala Thr Lys Ile Ala Met Gln Met Thr Cys Lys Leu Gly Gly Glu
             240                 245                 250

 ctg tgg gct gtg gaa ata cct tta aag tcc ctg atg gtg gtc ggt att      876
 Leu Trp Ala Val Glu Ile Pro Leu Lys Ser Leu Met Val Val Gly Ile
         255                 260                 265

 gat gtc tgt aaa gat gca ctc agc aag gac gtg atg gtt gtt gga tgc      924
 Asp Val Cys Lys Asp Ala Leu Ser Lys Asp Val Met Val Val Gly Cys
     270                 275                 280

 gtg gcc agt gtt aac ccc aga atc acc agg tgg ttt tcc cgc tgt atc      972
 Val Ala Ser Val Asn Pro Arg Ile Thr Arg Trp Phe Ser Arg Cys Ile
 285                 290                 295                 300

 ctt cag aga aca atg act gat gtt gca gat tgc ttg aaa gtt ttc atg     1020
 Leu Gln Arg Thr Met Thr Asp Val Ala Asp Cys Leu Lys Val Phe Met
                 305                 310                 315

 act gga gca ctc aac aaa tgg tac aag tac aat cat gat ttg cca gca     1068
 Thr Gly Ala Leu Asn Lys Trp Tyr Lys Tyr Asn His Asp Leu Pro Ala
             320                 325                 330

 cgg ata att gtg tac cgt gct ggt gta ggg gat ggt cag ctg aaa aca     1116
 Arg Ile Ile Val Tyr Arg Ala Gly Val Gly Asp Gly Gln Leu Lys Thr
         335                 340                 345

 ctt att gaa tat gaa gtc cca cag ctg ctg agc agt gtg gca gaa tcc     1164
 Leu Ile Glu Tyr Glu Val Pro Gln Leu Leu Ser Ser Val Ala Glu Ser
     350                 355                 360

 agc tca aat acc agc tca aga ctg tcg gtg att gtg gtc agg aag aag     1212
 Ser Ser Asn Thr Ser Ser Arg Leu Ser Val Ile Val Val Arg Lys Lys
 365                 370                 375                 380

 tgc atg cca cga ttc ttt acc gaa atg aac cgc act gta cag aac ccc     1260
 Cys Met Pro Arg Phe Phe Thr Glu Met Asn Arg Thr Val Gln Asn Pro
                 385                 390                 395

 cca ctt ggc act gtt gtg gat tca gaa gca aca cgt aac gaa tgg tat     1308
 Pro Leu Gly Thr Val Val Asp Ser Glu Ala Thr Arg Asn Glu Trp Tyr
             400                 405                 410

 gac ttt tat ctg atc agc cag gtg gcc tgc cgg gga act gtt agt cct     1356
 Asp Phe Tyr Leu Ile Ser Gln Val Ala Cys Arg Gly Thr Val Ser Pro
         415                 420                 425

 acc tac tat aat gtc atc tat gat gac aac ggc ttg aag ccc gac cat     1404
 Thr Tyr Tyr Asn Val Ile Tyr Asp Asp Asn Gly Leu Lys Pro Asp His
     430                 435                 440

 atg cag aga ctt aca ttc aaa ttg tgc cac ctg tac tac aac tgg ccg     1452
 Met Gln Arg Leu Thr Phe Lys Leu Cys His Leu Tyr Tyr Asn Trp Pro
 445                 450                 455                 460

 ggc ata gtc agt gtc cca gca cca tgt cag tat gct cac aag ctg acc     1500
 Gly Ile Val Ser Val Pro Ala Pro Cys Gln Tyr Ala His Lys Leu Thr
                 465                 470                 475

 ttt ctg ggg gca caa agc att cat aaa gaa ccc agt ctg gaa tta gcc     1548
 Phe Leu Gly Ala Gln Ser Ile His Lys Glu Pro Ser Leu Glu Leu Ala
             480                 485                 490

 aac cat ctc ttc tac ctg tga tg gcatgaacta ctggcatcac tagatggaca     1601
 Asn His Leu Phe Tyr Leu 
         495

 atccaagaag aaattggtat actttgtgca aatctgccat aagctcaagg ctgtgactgg   1661

 ggaaaaagat tgagcttagt tttcatgtct aggaaaaaaa gcaaaacaac ttaatctgaa   1721

 acagttttaa aaaatgtgtg ttattttgtt ttaaagagtt gtatgcttgg ggtaaatttt   1781

 cattgtcata tgtggaattt aaatatacca tcatctacaa agaattccac agagttaaat   1841

 atcttaagtt aaacacttaa aataagtgtt tgcgtgatat tttgatgaca gataaacaga   1901

 gtctaattcc caccccaaat tttgctgagg ttttcttaat gttgtagagc attttgtaga   1961

 gtggtttaaa tagttgaaaa taaagttcag aacatcaaaa aaaaaaaa                2009




      <210> 323
      <211> 723
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(480)

      <400> 323
 tttttgctgt aacagtgttt attg   atg atg agt cca ggg ctc ctg ctg aag      51
                              Met Met Ser Pro Gly Leu Leu Leu Lys
                                1               5

 ccc tgg tgg gga ggg gca cag agc gag atg ggg cgt aat gga atg ctt       99
 Pro Trp Trp Gly Gly Ala Gln Ser Glu Met Gly Arg Asn Gly Met Leu
  10                  15                  20                  25

 gaa ggc tgc tcc gtg atg tcg gtc gga gct tcc aga cta ggc gag ggc      147
 Glu Gly Cys Ser Val Met Ser Val Gly Ala Ser Arg Leu Gly Glu Gly
                  30                  35                  40

 agg gtg agg cct cgg gca cac agc cgg cgc cca gtc acc cgg ccc aga      195
 Arg Val Arg Pro Arg Ala His Ser Arg Arg Pro Val Thr Arg Pro Arg
              45                  50                  55

 tgg agg gcg gcc ggg ccc tgc aca ggc act tgc caa ggt ggc tca cac      243
 Trp Arg Ala Ala Gly Pro Cys Thr Gly Thr Cys Gln Gly Gly Ser His
          60                  65                  70

 tca cgc aca ctc gta ctg aga ctc aag gcc gtc tcc aca act cca acc      291
 Ser Arg Thr Leu Val Leu Arg Leu Lys Ala Val Ser Thr Thr Pro Thr
      75                  80                  85

 agt gca aat gac tta gtg caa att aaa ttc aga agg gac ggg gga aac      339
 Ser Ala Asn Asp Leu Val Gln Ile Lys Phe Arg Arg Asp Gly Gly Asn
  90                  95                 100                 105

 aga gtc gtg gag gct ttg aat ctc tca gaa aaa agg aaa gac agg aaa      387
 Arg Val Val Glu Ala Leu Asn Leu Ser Glu Lys Arg Lys Asp Arg Lys
                 110                 115                 120

 gct cag aaa caa aga gac aga agg atg aaa aag aag aag agg gag gtg      435
 Ala Gln Lys Gln Arg Asp Arg Arg Met Lys Lys Lys Lys Arg Glu Val
             125                 130                 135

 gtg ggg acg gcg tca tcc cgc tgg agg agc tca gct ctg gga tga tgt      483
 Val Gly Thr Ala Ser Ser Arg Trp Arg Ser Ser Ala Leu Gly 
         140                 145                 150

 ggtggctggt ggtcaaccgt ccgccgcagg gggtggccat gaagatggag tcgccggtgc    543

 ggggtgggtg ctgcgggcgc tgctgttccg atggtgtctt tgatgttggg ctgatgaggt    603

 ctggttcctc tagcttcacc ttccagagcc gattcctgag tcaggtagtg cagtggttgt    663

 aaagtgcagc atattcattt ccaagctaga gggttttgtg tcccgattca aaggcccagt    723




      <210> 324
      <211> 1942
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(1370)

      <400> 324
 taagcttgcg gccgcctctc ccggggacaa tgtgggactg agcggcccag ccgccgtgcc     60

 gccgccgccg ccgccgcagg acagccccag cgagagccgg ccaggttgca gcgcggacac    120

 actcgcaggt cgctgtggcc ccagcctcgc ctgacaga    atg agc ggc tcg gac     173
                                              Met Ser Gly Ser Asp
                                                1               5

 ggg gga ctg gag gag gag cca gag ctc agc atc acc ctc acg ctg cgg      221
 Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser Ile Thr Leu Thr Leu Arg
                  10                  15                  20

 atg ctg atg cac ggg aag gaa gtg ggc agc atc atc ggg aag aag ggc      269
 Met Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys Gly
              25                  30                  35

 gag act gta aag cga atc cgg gag cag agc agt gcc cgg atc acc atc      317
 Glu Thr Val Lys Arg Ile Arg Glu Gln Ser Ser Ala Arg Ile Thr Ile
          40                  45                  50

 tcc gag ggc tcc tgc cct gaa cgc atc acc acc atc acc ggg tct aca      365
 Ser Glu Gly Ser Cys Pro Glu Arg Ile Thr Thr Ile Thr Gly Ser Thr
      55                  60                  65

 gca gct gtc ttc cat gca gtc tcc atg att gct ttc aaa ctg gat gag      413
 Ala Ala Val Phe His Ala Val Ser Met Ile Ala Phe Lys Leu Asp Glu
  70                  75                  80                  85

 gac ctt tgt gct gct cct gca aat ggt gga aat gtc tcc agg cct cca      461
 Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn Val Ser Arg Pro Pro
                  90                  95                 100

 gtg acc ctg cgc ctt gtc atc cct gcc agt cag tgt ggc tca ctg att      509
 Val Thr Leu Arg Leu Val Ile Pro Ala Ser Gln Cys Gly Ser Leu Ile
             105                 110                 115

 ggg aag gct ggc acc aag atc aag gag atc cga gag act acg ggt gcc      557
 Gly Lys Ala Gly Thr Lys Ile Lys Glu Ile Arg Glu Thr Thr Gly Ala
         120                 125                 130

 cag gta cag gtg gca ggg gac ctg ctc ccc aac tcc aca gag cga gct      605
 Gln Val Gln Val Ala Gly Asp Leu Leu Pro Asn Ser Thr Glu Arg Ala
     135                 140                 145

 gtt acg gta tct ggg gtg cct gat gcc atc atc ctg tgt gtg cgc cag      653
 Val Thr Val Ser Gly Val Pro Asp Ala Ile Ile Leu Cys Val Arg Gln
 150                 155                 160                 165

 atc tgc gct gtt atc ctg gag tcc cca ccc aaa gga gcc act atc ccc      701
 Ile Cys Ala Val Ile Leu Glu Ser Pro Pro Lys Gly Ala Thr Ile Pro
                 170                 175                 180

 tac cat ccg agc ctc tcc cta ggt act gtt ctt ctc tct gcc aac cag      749
 Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu Leu Ser Ala Asn Gln
             185                 190                 195

 ggc ttc tct gtc cag ggt cag tat ggg gct gtg acc cca gct gag gtc      797
 Gly Phe Ser Val Gln Gly Gln Tyr Gly Ala Val Thr Pro Ala Glu Val
         200                 205                 210

 acc aag ctc cag cag ctc tca agc cat gcg gtc ccc ttt gcc aca ccc      845
 Thr Lys Leu Gln Gln Leu Ser Ser His Ala Val Pro Phe Ala Thr Pro
     215                 220                 225

 agc gtg gtg cca gga ctg gat ccc ggc aca cag acc agc tca cag gag      893
 Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gln Thr Ser Ser Gln Glu
 230                 235                 240                 245

 ttc ttg gtt ccc aac gat ttg att ggc tgt gtg atc ggg cgc cag ggc      941
 Phe Leu Val Pro Asn Asp Leu Ile Gly Cys Val Ile Gly Arg Gln Gly
                 250                 255                 260

 agc aag atc agc gag atc cgg cag atg tca ggg gca cat atc aag atc      989
 Ser Lys Ile Ser Glu Ile Arg Gln Met Ser Gly Ala His Ile Lys Ile
             265                 270                 275

 ggg aac caa gca gag ggc gct ggg gag cgg cat gtc acc atc act ggc     1037
 Gly Asn Gln Ala Glu Gly Ala Gly Glu Arg His Val Thr Ile Thr Gly
         280                 285                 290

 tct ccg gtc tcc atc gcc ctg gcc cag tac ctc atc act gcc tgt cta     1085
 Ser Pro Val Ser Ile Ala Leu Ala Gln Tyr Leu Ile Thr Ala Cys Leu
     295                 300                 305

 gag acg gcc aag tct acc tct ggg ggg acg ccc agc tcg gcc ccc gca     1133
 Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro Ser Ser Ala Pro Ala
 310                 315                 320                 325

 gac ctg cct gcc ccc ttc tcg cca ccc ctg acg gcc ctg ccc aca gct     1181
 Asp Leu Pro Ala Pro Phe Ser Pro Pro Leu Thr Ala Leu Pro Thr Ala
                 330                 335                 340

 ccc cct ggc ctg ctg ggc aca ccc tat gcc atc tcc ctc tcc aac ttc     1229
 Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala Ile Ser Leu Ser Asn Phe
             345                 350                 355

 atc ggc ctc aag ccc atg ccc ttc ttg gct tta cca cct gct tcc cca     1277
 Ile Gly Leu Lys Pro Met Pro Phe Leu Ala Leu Pro Pro Ala Ser Pro
         360                 365                 370

 ggg ccg ccg ccg ggc ttg gcg gcc tac act gcc aag atg gca gca gct     1325
 Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala Lys Met Ala Ala Ala
     375                 380                 385

 aat ggg agc aag aag gct gag cgg cag aaa ttc tcc ccc tac tga ggc     1373
 Asn Gly Ser Lys Lys Ala Glu Arg Gln Lys Phe Ser Pro Tyr 
 390                 395                 400

 cagctgaggt acaggcaggg gcaggcagga ccaccagcag ggggctgcct ctgcacccta   1433

 cccgcccaag gagactccac cctggggtcc caaacgccgc taacgcccag acgcatggat   1493

 gcacccccta ccctgcctcc atctatggga gttctttctc tcagagtggg ggcagtttct   1553

 ggcccagggg tctgagctgc ggcagcccca gggcaggggg ccctacctcc tcagctctgt   1613

 gcttggatac agggagcagc caggagactc cctagtgccc ccaccatggc gggtgtcact   1673

 cacgcactcc ccatccctta gggcttcctg gcctactgca tccttgtggg agtcagggag   1733

 gagggcccgt tgggtagctg gggccaggct tctctcccca ccacctgcag atttcttgct   1793

 gcccacagct ccccctggcc tgctgggcac tgccaggtag ctgggggagt ggcatggggc   1853

 aggggcccag ttctcagcag cagacactct gtacagtttt ttcaatccct gtttttgaat   1913

 aaatattctc agcgaccaaa aaaaaaaaa                                     1942




      <210> 325
      <211> 884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (254)..(817)

      <400> 325
 tcccatcatg accactgctt gctcagataa tgacgtgcgg aaggttggaa gtctggctgg     60

 atcttctgtc tttctgcctg tctctgtgtc tcgtaccttc gctgtcagca gaggggactc    120

 tctggcaggc tccccagtaa accggtcccc ttctcgctgc agtgggttga atcgctctga    180

 gtctccaaac cgagagcgca gagactttgg gggcagcaac acccagctgt acagcagcag    240

 caacaacctc tac   atg cct gac tac tca gtc cac atc ctc agc gat gtg     289
                  Met Pro Asp Tyr Ser Val His Ile Leu Ser Asp Val
                    1               5                  10

 cag ttt gtg aag atc aca cgg cag caa tat cag aac gca ctc act gcc      337
 Gln Phe Val Lys Ile Thr Arg Gln Gln Tyr Gln Asn Ala Leu Thr Ala
          15                  20                  25

 tgc cac atg gac agc tca cct cag tcc cct gac atg gag gcc ttc aca      385
 Cys His Met Asp Ser Ser Pro Gln Ser Pro Asp Met Glu Ala Phe Thr
      30                  35                  40

 gac ggg gac tcc act aag gcc ccc aca acc cgg ggc aca ccc cag acc      433
 Asp Gly Asp Ser Thr Lys Ala Pro Thr Thr Arg Gly Thr Pro Gln Thr
  45                  50                  55                  60

 cct aag gat gac ccc gcc atc acg ctc ctc aac aac agg aac agc ctg      481
 Pro Lys Asp Asp Pro Ala Ile Thr Leu Leu Asn Asn Arg Asn Ser Leu
                  65                  70                  75

 ccg tgc agc cgc tca gac ggg ctg aga agc ccc agc gag gta gtg tac      529
 Pro Cys Ser Arg Ser Asp Gly Leu Arg Ser Pro Ser Glu Val Val Tyr
              80                  85                  90

 ctg agg atg gag gag ctg gcc ttc acc cag gaa gaa atg act gac ttc      577
 Leu Arg Met Glu Glu Leu Ala Phe Thr Gln Glu Glu Met Thr Asp Phe
          95                 100                 105

 gag gag cac agc aca cag cag ctc acg ctg tct cct gca gcc gtt ccc      625
 Glu Glu His Ser Thr Gln Gln Leu Thr Leu Ser Pro Ala Ala Val Pro
     110                 115                 120

 acg aga gca gca tca gat agt gaa tgt tgt aac atc aac ctg gat aca      673
 Thr Arg Ala Ala Ser Asp Ser Glu Cys Cys Asn Ile Asn Leu Asp Thr
 125                 130                 135                 140

 gag acc agc ccc tgc agt agc gat ttt gag gaa aac gtg ggc aag aag      721
 Glu Thr Ser Pro Cys Ser Ser Asp Phe Glu Glu Asn Val Gly Lys Lys
                 145                 150                 155

 ctg ctg aga acc ttg agt ggc caa aaa agg aag agg tca cca gaa gga      769
 Leu Leu Arg Thr Leu Ser Gly Gln Lys Arg Lys Arg Ser Pro Glu Gly
             160                 165                 170

 gag aga acc tct gag gac aac tcc aat tta aca cct ctg atc aca tga      817
 Glu Arg Thr Ser Glu Asp Asn Ser Asn Leu Thr Pro Leu Ile Thr 
         175                 180                 185

 cagggcaaag ccagcattca ctggacgaaa tcgtcgacag cgaagtcgac ccgggaattc    877

 cggaggg                                                              884




      <210> 326
      <211> 611
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (287)..(568)

      <400> 326
 caactttttg tcctgagggc cagagaaagg gagaaggggg tggggggaca gccacgtggc     60

 cgcaggagga tttacaacat tttctttcgc catcgatgtt atcgcaaaat gtgtgagaga    120

 agcggctgcg cagcccggac gggagcgtga gggtgcgggc caggtaagca gccccggcgg    180

 tttcgccgca tacgggactg cggggcgacc gcgggcacca gccacgcgca gcggctccgc    240

 ggggtctcgg ccgggtccgc gctctgaagg atctcgagag ccatgg   atg gtg cag     295
                                                      Met Val Gln
                                                        1

 gcg gga ccc tcg agc tgc agc atc tcc ggt gac ccg ggg ttg ccg agg      343
 Ala Gly Pro Ser Ser Cys Ser Ile Ser Gly Asp Pro Gly Leu Pro Arg
       5                  10                  15

 agg tgg aga cca gca cag gtg gtc cgg ccc ggg cgc ctc cga atc cgg      391
 Arg Trp Arg Pro Ala Gln Val Val Arg Pro Gly Arg Leu Arg Ile Arg
  20                  25                  30                  35

 ggg tgg tca aga cgg atc ccc aag gct gag gtc ggc agt ccc ggg gac      439
 Gly Trp Ser Arg Arg Ile Pro Lys Ala Glu Val Gly Ser Pro Gly Asp
                  40                  45                  50

 tcg cag ctg ttg agc ctg tgg aga cgc ggc ccc gtg acc gag gca ccc      487
 Ser Gln Leu Leu Ser Leu Trp Arg Arg Gly Pro Val Thr Glu Ala Pro
              55                  60                  65

 ttc agc aac ccg ggg gca gcg ttt tcc ccc tac cgg aaa tct gat ggg      535
 Phe Ser Asn Pro Gly Ala Ala Phe Ser Pro Tyr Arg Lys Ser Asp Gly
          70                  75                  80

 ctt atg aca tca tgg ctg gct gct gag cga tga agtggatg ccacaaagaa      586
 Leu Met Thr Ser Trp Leu Ala Ala Glu Arg 
      85                  90

 atccgacata tcagatagat tctga                                          611




      <210> 327
      <211> 1926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (983)..(1528)

      <400> 327
 tttattcagg tgaggaaggg agcacacagg agacagagag gactcagttg ggccactcaa     60

 gacccagccc agtctctgct tcctctgcca acatctttgc taagccttca gccagaacag    120

 ctatggtctg cgaagattaa gtaaagaaaa atagcagctc ctcctcctcc ttgtccatca    180

 gtgtgtgctc agactgttgt ttgatcctgt gggctggggg tcgtgagcgg cataccagtg    240

 tcctgcctct cttcttcttg atctcagcct gggcgcgcgc ccgggcccgc tgcagatgct    300

 cctcctgtag gatcttttgc atctggagct tctcttctcg aagtctgatg cgccgctcct    360

 tctcctttgc cctctcggcc tgctcgatct tgacctgggg cacgtgctcc aggttctcta    420

 gcagctcatc cagctggtgc tcaatgatgg tcagcatctg cacggtgccc aggttggcct    480

 cctgctgggt gccggtgcag tgccggtaca catccagcac cttgcagttc aggctctcta    540

 gcagcttatc ctgtggagga ggtggcttcc agcagggtgc tggcaggcag aaacccaccc    600

 ccatgccagt gccttcagcg gtggcctgct gacctcccag ggtgggggcc accgcttggc    660

 acacagtggg agctctgaga acatgggcta aaacagaact tggggaactg gcttttcttg    720

 gccagagcag cctatccccc gggccccctg gagtcagcca gatccctggt tccagcccct    780

 ctcccagctg cctctggtga gccaacgggg cccagtcccc tcctccaggg aaccctgcac    840

 cctgggcacc ccacagggct atgtcttctc tgagactgtt ctgacactta gaaaacagat    900

 aacagcccct ccatgtgggc tatatgagga gagaggagca gcaggcaggc agctcagccc    960

 agcctgggca cagccagtgc cc atg gat tct ggc tgt atc ggg agc gct gtc    1012
                          Met Asp Ser Gly Cys Ile Gly Ser Ala Val
                            1               5                  10

 ttg ctc atg gct gca tcc cac acc ctt ggc cct gtg cct ggc aca cag     1060
 Leu Leu Met Ala Ala Ser His Thr Leu Gly Pro Val Pro Gly Thr Gln
                  15                  20                  25

 cag gca ctt gac agt agg aag cca tcc cat gcc cgg ggt ggc ccc agg     1108
 Gln Ala Leu Asp Ser Arg Lys Pro Ser His Ala Arg Gly Gly Pro Arg
              30                  35                  40

 ctg tca ggt tgg gag cgg gct gag cct ttg tct ggg tcc tgg ctt ctg     1156
 Leu Ser Gly Trp Glu Arg Ala Glu Pro Leu Ser Gly Ser Trp Leu Leu
          45                  50                  55

 ctg ctc aga aca cca ctg gct ttc tct tct ctc cca att ctc tca ccc     1204
 Leu Leu Arg Thr Pro Leu Ala Phe Ser Ser Leu Pro Ile Leu Ser Pro
      60                  65                  70

 tct cag cct ggc ttg agg aca cgc ctc ttc ccc ccc ttc agg atc acc     1252
 Ser Gln Pro Gly Leu Arg Thr Arg Leu Phe Pro Pro Phe Arg Ile Thr
  75                  80                  85                  90

 ttg cca gac aca ata tat gtg ttt aag aag cag aca cat ttg ttg aat     1300
 Leu Pro Asp Thr Ile Tyr Val Phe Lys Lys Gln Thr His Leu Leu Asn
                  95                 100                 105

 aaa aga atg aag caa tgg atg agg cgt ggg ggc aac caa gct ggc tgg     1348
 Lys Arg Met Lys Gln Trp Met Arg Arg Gly Gly Asn Gln Ala Gly Trp
             110                 115                 120

 cac agg cat caa tac atg tgg tgg ctc ctg gag gga ggc agg gca agg     1396
 His Arg His Gln Tyr Met Trp Trp Leu Leu Glu Gly Gly Arg Ala Arg
         125                 130                 135

 gca gct gca ggg cac tca ccc ggg cct tgt cct cca tct tcc caa ggg     1444
 Ala Ala Ala Gly His Ser Pro Gly Pro Cys Pro Pro Ser Ser Gln Gly
     140                 145                 150

 ctg tca ggg ctc ctc cag tgg gtg ccc aag ggt ccc tcc tta ccc tgg     1492
 Leu Ser Gly Leu Leu Gln Trp Val Pro Lys Gly Pro Ser Leu Pro Trp
 155                 160                 165                 170

 gcc tct ggc cac ctt gat ccc cag cct acc tgc tga tcgc ccttgtactc     1542
 Ala Ser Gly His Leu Asp Pro Gln Pro Thr Cys 
                 175                 180

 gccgaagtgg aagactcggg ctttgagctc cagctcagct gctgtgtcct cctccttggt   1602

 gatggacatc atcattgtgg tgacccactg cttcagctgg ttgacctccc tgtccctgga   1662

 agaggggaaa accggcaggg catcagtcac tcagcacagc cctgggcaca tcgcttctct   1722

 gagcctgtct gtacagtgct ttgcccctac cagctgtcct gagggctgaa ggatcatggg   1782

 tgccaagtct ctgcatgccc agggggtcag aaatgctggt agaatgtagg ggaaaatgta   1842

 aaatatttaa caatcaacat taaagaaaat aaacagcttc attgaggcat aattcacaga   1902

 caataaaatt agcataacca tcat                                          1926




      <210> 328
      <211> 803
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (229)..(621)

      <400> 328
 attagaactt cttatctgaa gccataccac tcagagggaa tgcaaaatac atattgacat     60

 ctcctttagg atgtccttag agaattcatg gaaaagaagt taaataattt aaaagtgctt    120

 ttgggtacag ctatttagca ctagagggta agattagaca tagattgtaa agataataat    180

 agggttaggg ataggattag gatctgggtc agagtcaggg ccagaagt atg gtt aga     237
                                                      Met Val Arg
                                                        1

 ggt ggg gtc atg gtc agg gtc gag atc aaa gtc agg gtc aga att agg      285
 Gly Gly Val Met Val Arg Val Glu Ile Lys Val Arg Val Arg Ile Arg
       5                  10                  15

 gac cag gat agg gat cag gat tta ggt tca gtg tca aag tct tgg gac      333
 Asp Gln Asp Arg Asp Gln Asp Leu Gly Ser Val Ser Lys Ser Trp Asp
  20                  25                  30                  35

 aag gtt agg gtt aga att aga acc aga gct ttg ttc tcc tca ggt ccc      381
 Lys Val Arg Val Arg Ile Arg Thr Arg Ala Leu Phe Ser Ser Gly Pro
                  40                  45                  50

 acc cga gga tgg gtc acc atg gct ttg gag cgc ctg gta gtg tgg cat      429
 Thr Arg Gly Trp Val Thr Met Ala Leu Glu Arg Leu Val Val Trp His
              55                  60                  65

 gtc cac agt gaa gac cag agt ttc att gtc ctt aag act gac ctg ggg      477
 Val His Ser Glu Asp Gln Ser Phe Ile Val Leu Lys Thr Asp Leu Gly
          70                  75                  80

 aga tgt ggc tgt agg cca ttg agg aag gtg agg caa cag ctt cct gtc      525
 Arg Cys Gly Cys Arg Pro Leu Arg Lys Val Arg Gln Gln Leu Pro Val
      85                  90                  95

 tgc tcc ccg tgt gct gag gag gga gct ctg cca tgg gct tta ctt tca      573
 Cys Ser Pro Cys Ala Glu Glu Gly Ala Leu Pro Trp Ala Leu Leu Ser
 100                 105                 110                 115

 cat gtt ata ttc cac aag tct tgt ttt aca aaa gca tcc ctt cct tga      621
 His Val Ile Phe His Lys Ser Cys Phe Thr Lys Ala Ser Leu Pro 
                 120                 125                 130

 ggcttcggct gctcatcgct gctcatcatc atagcgtgcc ataacatata gtaagatttg    681

 ggtttgtttc tggggagata tcttggtata gagaaaggag aaatgcttag agccaccatc    741

 aggacagttg ggatgaaagt tgggtatagg cagaggctgg agacgaaatc gtcgacagcg    801

 aa                                                                   803




      <210> 329
      <211> 986
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(577)

      <400> 329
 taagcttgcg gccgccgcgg gcgcgggccg ctcgctctac ggtgggcccg agctcgtgtt     60

 ccccgaggcc   atg aac cac ccc gcg ctg acc gtg cat ccg gcg cac cag     109
              Met Asn His Pro Ala Leu Thr Val His Pro Ala His Gln
                1               5                  10

 ctg ggc gcc tcc ccg ctg cag ccc ccg cac tcc ttc ttc ggc gcc cag      157
 Leu Gly Ala Ser Pro Leu Gln Pro Pro His Ser Phe Phe Gly Ala Gln
      15                  20                  25

 cac cgg gac cct ctc cat ttc tac ccc tgg gtc ctg cgg aac cgc ttc      205
 His Arg Asp Pro Leu His Phe Tyr Pro Trp Val Leu Arg Asn Arg Phe
  30                  35                  40                  45

 ttc ggc cac cgc ttc cag gcc agc gac gtg ccc cag gac ggg ctg ctt      253
 Phe Gly His Arg Phe Gln Ala Ser Asp Val Pro Gln Asp Gly Leu Leu
                  50                  55                  60

 ctg cac ggc ccc ttc gca cgc aag ccc aag cgg atc cgc acg gcc ttc      301
 Leu His Gly Pro Phe Ala Arg Lys Pro Lys Arg Ile Arg Thr Ala Phe
              65                  70                  75

 tcg ccc tcg cag ctg ctg cgg ctg gag cgc gcc ttc gag aag aac cac      349
 Ser Pro Ser Gln Leu Leu Arg Leu Glu Arg Ala Phe Glu Lys Asn His
          80                  85                  90

 tac gtg gtg ggc gcc gag cgg aag cag ctg gcc ggc agt ctc agc ctc      397
 Tyr Val Val Gly Ala Glu Arg Lys Gln Leu Ala Gly Ser Leu Ser Leu
      95                 100                 105

 tcc gag acg cag gtg aag gtg tgg ttc cag aac cgg agg aca aag tac      445
 Ser Glu Thr Gln Val Lys Val Trp Phe Gln Asn Arg Arg Thr Lys Tyr
 110                 115                 120                 125

 aaa cgg cag aag ctg gag gag gaa ggg cct gag tcc gag cag aag aag      493
 Lys Arg Gln Lys Leu Glu Glu Glu Gly Pro Glu Ser Glu Gln Lys Lys
                 130                 135                 140

 aag ggc tcc cat cac atc aac cgg tgg cgc att gcc acg aag cag gcc      541
 Lys Gly Ser His His Ile Asn Arg Trp Arg Ile Ala Thr Lys Gln Ala
             145                 150                 155

 aat ggg gag gac atc gat gtc acc tcc aat gac tag ggtg ggcaaccaca      591
 Asn Gly Glu Asp Ile Asp Val Thr Ser Asn Asp 
         160                 165

 aacccacgag ggcagagtgc tgcttgctgc tggccaggcc cctgcgtggg cccaagctgg    651

 actctggcca ctccctggcc aggctttggg gaggcctgga gtcatggccc cacagggctt    711

 gaagcccggg gccgccattg acagagggac aagcaatggg ctggctgagg cctgggacca    771

 cttggccttc tcctcggaga gcctgcctgc ctgggcgggc ccgcccgcca ccgcagcctc    831

 ccagctgctc tccgtgtctc caatctccct tttgttttga tgcatttctg ttttaattta    891

 ttttccaggc accactgtag tttagtgatc cccagtgtcc cccttcccta tgggaataat    951

 aaaagtctct ctcttaatga caaaaaaaaa aaaaa                               986




      <210> 330
      <211> 575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(486)

      <400> 330
 agg  atg gag atc cct gtg cct gtg cag ccg tct tgg ctg cgc cgc gcc      48
      Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala
        1               5                  10                  15

 tcg gcc ccg ttg ccc gga ctt tcg gcg ccc gga cgc ctc ttt gac cag       96
 Ser Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln
                  20                  25                  30

 cgc ttc ggc gag ggg ctg ctg gag gcc gag ctg gct gcg ctc tgc ccc      144
 Arg Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro
              35                  40                  45

 acc acg ctc gcc ccc tac tac ctg cgc gca ccc agc gtg gcg ctg ccc      192
 Thr Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro
          50                  55                  60

 gtc gcc cag gtg ccg acg gac ccc ggc cac ttt tcg gtg ctg cta gac      240
 Val Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp
      65                  70                  75

 gtg aag cac ttc tcg ccg gag gaa att gct gtc aag gtg gtg ggc gaa      288
 Val Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu
  80                  85                  90                  95

 cac gtg gag gtg cac gcg cgc cac gag gag cgc ccg gat gag cac gga      336
 His Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly
                 100                 105                 110

 ttc gtc gcg cgc gag ttc cac cgt cgc tac cgc ctg ccg cct ggc gtg      384
 Phe Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val
             115                 120                 125

 gat ccg gct gcc gtg acg tcc gcg ctg tcc ccc gag ggc gtc ctg tcc      432
 Asp Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser
         130                 135                 140

 atc cag gcc gca cca gcg tcg gcc cag gcc cca ccg cca gcc gca gcc      480
 Ile Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala
     145                 150                 155

 aag tag gagggggctg ggccgcgccc gcaccccggg agcctcctca ggctccctct       536
 Lys 
 160

 attaaagccg atctgactcc gcccaaaaaa aaaaaaaaa                           575




      <210> 331
      <211> 812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(609)

      <400> 331
 cttggcacga ggagctgagc ctgacccagc aggtcccagc agcctggcag cccggccagc     60
                                                                 
 atg cag cag cag cct ctg ccc ggg cct ggc gcc ccc aca act gag cca      108
 Met Gln Gln Gln Pro Leu Pro Gly Pro Gly Ala Pro Thr Thr Glu Pro
   1               5                  10                  15

 acc aag cct ccc tac agc tac atc gcc ctt att gct atg gcc atc cag      156
 Thr Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Ala Met Ala Ile Gln
              20                  25                  30

 agc tca ccg ggg cag cgg gcc acc ctc agt ggc atc tac cgc tac atc      204
 Ser Ser Pro Gly Gln Arg Ala Thr Leu Ser Gly Ile Tyr Arg Tyr Ile
          35                  40                  45

 atg ggc cga ttc gcc ttc tac cgc cac aac cgg ccc ggc tgg cag aac      252
 Met Gly Arg Phe Ala Phe Tyr Arg His Asn Arg Pro Gly Trp Gln Asn
      50                  55                  60

 agc atc cgc cac aac ctg tca ctc aac gag tgc ttt gtc aag gtg ccc      300
 Ser Ile Arg His Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro
  65                  70                  75                  80

 cgc gat gac cgc aag cca ggc aag ggc agc tac tgg acg ctg gac cct      348
 Arg Asp Asp Arg Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro
                  85                  90                  95

 gac tgc cac gac atg ttt gag cac ggc agc ttc cta cgc cgc cgc cgc      396
 Asp Cys His Asp Met Phe Glu His Gly Ser Phe Leu Arg Arg Arg Arg
             100                 105                 110

 cgc ttc acc cgg cag aca ggt gct gag ggc acc cgg ggc ccc gcc aag      444
 Arg Phe Thr Arg Gln Thr Gly Ala Glu Gly Thr Arg Gly Pro Ala Lys
         115                 120                 125

 gca cgc cgt gga ccc ctc agg gcg acc agc cag gac cca gga gtc ccc      492
 Ala Arg Arg Gly Pro Leu Arg Ala Thr Ser Gln Asp Pro Gly Val Pro
     130                 135                 140

 aac gcc acg acc ggc agg cag tgc tca ttc cca cca gag ctg cca gat      540
 Asn Ala Thr Thr Gly Arg Gln Cys Ser Phe Pro Pro Glu Leu Pro Asp
 145                 150                 155                 160

 ccc aag ggc cta agc tta ggg ggg tct ggt ggg ggc cat gcc agc cag      588
 Pro Lys Gly Leu Ser Leu Gly Gly Ser Gly Gly Gly His Ala Ser Gln
                 165                 170                 175

 tat gtg ccc agc aac cac tga tg gcaggcctcg gcacccatgg agcccaaaga      641
 Tyr Val Pro Ser Asn His 
             180

 gattccacgc ccaagcctgc atgccgggga gctcccgtgg cacctcatct tcctcatgcc    701

 agcgtttggg ttcctgcggg tctcagaagc gggagttaat aggcctagcc gttggcccgg    761

 atcggacggg gcaaccagtg tggggccgat tgggggggcc ggctacggtg a             812




      <210> 332
      <211> 1514
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (396)..(1205)

      <400> 332
 taagaacact gagaacaaag gtgaaatgtc tagaagatga acgattaaga acagaagatg     60

 aattatcaaa atataaggaa attattaatc gccaaaaagc tgaaattcag aatttattgg    120

 acaaggtgaa aactgcagat cagctacagg agcagcttca aagaggtaag caagaaattg    180

 aaaatttgaa agaagaagtg gaaagtctta attctttgat taatgaccta caaaaagaca    240

 tcgaaggcag taggaaaaga gaatctgagc tgctgctgtt tacagaaagg ctcactagta    300

 agaatgcaca gcttcagtct gaatccaatt ctttgcagtc acaatttgat aaagtttcct    360

 gtagtgaaag tcagttacaa agccagtgtg aacaa   atg aaa cag aca aat att     413
                                          Met Lys Gln Thr Asn Ile
                                            1               5

 aat ttg gaa agt agg ttg ttg aaa gag gaa gaa ctg cga aaa gag gaa      461
 Asn Leu Glu Ser Arg Leu Leu Lys Glu Glu Glu Leu Arg Lys Glu Glu
              10                  15                  20

 gtc caa act ctg caa gct gaa ctc gct tgt aga caa aca gaa gtt aaa      509
 Val Gln Thr Leu Gln Ala Glu Leu Ala Cys Arg Gln Thr Glu Val Lys
          25                  30                  35

 gca ttg agt acc cag gta gaa gaa tta aaa gat gag tta gta act cag      557
 Ala Leu Ser Thr Gln Val Glu Glu Leu Lys Asp Glu Leu Val Thr Gln
      40                  45                  50

 aga cgt aaa cat gcc tct agt atc aag gat ctc acc aaa caa ctt cag      605
 Arg Arg Lys His Ala Ser Ser Ile Lys Asp Leu Thr Lys Gln Leu Gln
  55                  60                  65                  70

 caa gca cga aga aaa tta gat cag gtt gag agt gga agc tat gac aaa      653
 Gln Ala Arg Arg Lys Leu Asp Gln Val Glu Ser Gly Ser Tyr Asp Lys
                  75                  80                  85

 gaa gtc agc agc atg gga agt cgt tct agt tca tca ggg tcc ctg aat      701
 Glu Val Ser Ser Met Gly Ser Arg Ser Ser Ser Ser Gly Ser Leu Asn
              90                  95                 100

 gct cga agc agt gca gaa gat cga tct cca gaa aat act ggg tcc tca      749
 Ala Arg Ser Ser Ala Glu Asp Arg Ser Pro Glu Asn Thr Gly Ser Ser
         105                 110                 115

 gta gct gtg gat aac ttt cca caa gta gat aag gcc atg ttg att gag      797
 Val Ala Val Asp Asn Phe Pro Gln Val Asp Lys Ala Met Leu Ile Glu
     120                 125                 130

 aga ata gtt agg ctg caa aaa gca cat gcc cgg aaa aat gaa aag ata      845
 Arg Ile Val Arg Leu Gln Lys Ala His Ala Arg Lys Asn Glu Lys Ile
 135                 140                 145                 150

 gaa ttt atg gag gac cac atc aaa caa ctg gtg gaa gaa att agg aaa      893
 Glu Phe Met Glu Asp His Ile Lys Gln Leu Val Glu Glu Ile Arg Lys
                 155                 160                 165

 aaa aca aaa ata att caa agt tat att tta cga gaa gaa tca ggc aca      941
 Lys Thr Lys Ile Ile Gln Ser Tyr Ile Leu Arg Glu Glu Ser Gly Thr
             170                 175                 180

 ctt tct tca gag gca tct gat ttt aac aaa gtt cat tta agt aga cgg      989
 Leu Ser Ser Glu Ala Ser Asp Phe Asn Lys Val His Leu Ser Arg Arg
         185                 190                 195

 ggt ggc atc atg gca tct tta tat aca tcc cat cca gct gac aat gga     1037
 Gly Gly Ile Met Ala Ser Leu Tyr Thr Ser His Pro Ala Asp Asn Gly
     200                 205                 210

 tta aca ttg gag ctc tct ttg gaa atc aac cga aaa tta cag gct gtt     1085
 Leu Thr Leu Glu Leu Ser Leu Glu Ile Asn Arg Lys Leu Gln Ala Val
 215                 220                 225                 230

 ttg gag gat acg tta cta aaa aat att act ttg aag gaa aat cta caa     1133
 Leu Glu Asp Thr Leu Leu Lys Asn Ile Thr Leu Lys Glu Asn Leu Gln
                 235                 240                 245

 aca ctt gga aca gaa ata gaa cgt ctt att aaa cac cag cat gaa cta     1181
 Thr Leu Gly Thr Glu Ile Glu Arg Leu Ile Lys His Gln His Glu Leu
             250                 255                 260

 gaa cag agg aca aag aaa acc taa aacaagcctc ttgctcagta aagagacaaa    1235
 Glu Gln Arg Thr Lys Lys Thr 
         265

 agccacacag gagtaggtgc cactgacctc tattgttgga gactttgttc cactttttgt   1295

 ttcagccagt aaaaatattg ttttgcttca tctgtacaca aaaaaatacc cttttacaat   1355

 atgaatgcat tgctgtatat actgtaagac tgaaagcttt gatgaaattt gtttttgtat   1415

 ggtgcaatat gacagcctgt cattgaatct aaacaactta atttgcttgt attcataaga   1475

 agtgttgaac attacaaggg cttttataaa aaaaaaaaa                          1514




      <210> 333
      <211> 543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(237)

      <220>
      <221> misc_feature
      <222> (1)...(543)
      <223> n = a,t,c or g

      <400> 333
 aaattgaaaa aaaattggta nacacttgac cctgtgaagg ggctgctgaa taaagcc        57                                                                 
 atg tct cat tta cct gct gtc tct cca gtg ttc ttc cag ctc cct gcc      105
 Met Ser His Leu Pro Ala Val Ser Pro Val Phe Phe Gln Leu Pro Ala
   1               5                  10                  15

 cca cat cca ccc act gtc ctc aga cct cag ctg ggg ctg cac ccc aac      153
 Pro His Pro Pro Thr Val Leu Arg Pro Gln Leu Gly Leu His Pro Asn
              20                  25                  30

 cct gag tgt gac aga gag aag atg agt gtt aga gat cat gat cct gaa      201
 Pro Glu Cys Asp Arg Glu Lys Met Ser Val Arg Asp His Asp Pro Glu
          35                  40                  45

 gtg ctg acg aga aat tca gga agc ctg caa gcc tag aggt cagctcagtg      251
 Val Leu Thr Arg Asn Ser Gly Ser Leu Gln Ala 
      50                  55

 gccacctttt gaagcccagg gcaccattgg aagctgccta gtttgaggca cggatggaag    311

 aggaaaacac tgagaacaac atccctcttc ctgaggaatg catacaaggg tgcttggggg    371

 tgggttgggg atcccaaggc aggagagcca aagctggagt cagaggaagc tcttcttctg    431

 aaacctgtaa tttcaatgtc ttttcctttc ccttcaaaat tgtaatttcc ttctgaaatc    491

 attctaaccc tttagtaaag acattaattt aaagatgttt aaaaaaaaaa aa            543




      <210> 334
      <211> 1209
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (571)..(954)

      <400> 334
 cccatggatt caggtgcaga agagggccag gactaggtct tctgcccttt ctatgacctc     60

 agagcctaag ttttcacctt agcagagttc tgagactggg tgaggcaggg acttctggaa    120

 ggttctgttc ctgccctttt tagctgagga cgtgtgtgag ccttatctga cccctgtggc    180

 tcatttttct cttctgacct ggcagctttc cttgttgttc taagcctgtc catgttgtgg    240

 tttatttctg gatgctcagt ggcacggggc ctcctccaaa gacaggttgt cattttcatg    300

 gtaacaacac tgttctctgt tgagtctgcc ctccgtgttg tagccagacc ttgtggagat    360

 ggctttgcgg cggtgtgagc tggcggtcag gagtgagggc ccagccttcc cggcacctcc    420

 cagccaggtg gccctgcccg acctgtgggg tgaggcagcc aaggttcctt ccatcccccc    480

 agttgtggag acacagggct gcctcaccct ttcattgccg aggttcctac ctcatggaca    540

 gaacaaacac ctcagcaatg aaacctgttc     atg tct aag agc agc tgg gct     591
                                      Met Ser Lys Ser Ser Trp Ala
                                        1               5

 ggg aat ctt ccc ctt tgt tca agg cct tcc agt aag gcc cag ctg tcc      639
 Gly Asn Leu Pro Leu Cys Ser Arg Pro Ser Ser Lys Ala Gln Leu Ser
          10                  15                  20

 cct tgc tgt gca tgg ggc tct ggg gag ttc cac tct ttg atg gag ggc      687
 Pro Cys Cys Ala Trp Gly Ser Gly Glu Phe His Ser Leu Met Glu Gly
      25                  30                  35

 aga ggc cct gag tgc aaa ctc cct ggg aag agt ccc atg cta aca tgt      735
 Arg Gly Pro Glu Cys Lys Leu Pro Gly Lys Ser Pro Met Leu Thr Cys
  40                  45                  50                  55

 gct caa agg agc cct cct ctc aca tct cag cga cca aga acc cca atc      783
 Ala Gln Arg Ser Pro Pro Leu Thr Ser Gln Arg Pro Arg Thr Pro Ile
                  60                  65                  70

 cct aat cag agc tct gcc tct gcc cca cat ggg gcc cta ccc cac ttc      831
 Pro Asn Gln Ser Ser Ala Ser Ala Pro His Gly Ala Leu Pro His Phe
              75                  80                  85

 cag gga gca cag cag cct ctg acc cta gcc ctg ccc tgg cag cat ggg      879
 Gln Gly Ala Gln Gln Pro Leu Thr Leu Ala Leu Pro Trp Gln His Gly
          90                  95                 100

 acc tgc caa cag ctg agg gtg gca gca gtc tgt gct ggg atc tgt gcc      927
 Thr Cys Gln Gln Leu Arg Val Ala Ala Val Cys Ala Gly Ile Cys Ala
     105                 110                 115

 cgg atc tgg gcc cat tct ctt cag taa ggctg gagctgcgag ccagtttgct      979
 Arg Ile Trp Ala His Ser Leu Gln 
 120                 125

 gccctcccag atcctgtgtc cattctgaag aatggggaca cctccctatt acagatgaga   1039

 acagagggga catgaactcc ttgtaggcag ggctgggaag ggaccctgga ctgtgtctcc   1099

 tccctgtacc tggtcaactc caagagctgg caccatgccg tgagggctat ttggatatgc   1159

 ctcacaggtt gctgtgagcg acgggagcgt ggctggcgta aacgtcgtcc              1209




      <210> 335
      <211> 1205
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(1029)

      <400> 335
 cgtaaataga gtccaagtgg gcggagagcc gtcccgcgcc gcccgctc atg tct cta      57
                                                      Met Ser Leu
                                                        1

 cat gag ccg act gtc ctg gcc gcc tgg cac agc tgc gcg cgg cgg ggc      105
 His Glu Pro Thr Val Leu Ala Ala Trp His Ser Cys Ala Arg Arg Gly
       5                  10                  15

 agc tgc tcg tcc ccc cgc gcc ccc ggc ccg gac act tgg cgg gtg cca      153
 Ser Cys Ser Ser Pro Arg Ala Pro Gly Pro Asp Thr Trp Arg Val Pro
  20                  25                  30                  35

 cga tgg acc cgc agc agc acg tgc ggt ccc ccg gcg ttc ctg ggc gtg      201
 Arg Trp Thr Arg Ser Ser Thr Cys Gly Pro Pro Ala Phe Leu Gly Val
                  40                  45                  50

 ttc ggc cgc cgt gcg cgg acc tcg gcg gga gtt ggg gcg tgg ggg gcg      249
 Phe Gly Arg Arg Ala Arg Thr Ser Ala Gly Val Gly Ala Trp Gly Ala
              55                  60                  65

 gcg gcg gtg ggg cgg aca gcc ggg gtg cgc act tgg gcc ccc ctg gcc      297
 Ala Ala Val Gly Arg Thr Ala Gly Val Arg Thr Trp Ala Pro Leu Ala
          70                  75                  80

 atg gcg gcg aag gtg gac ctg agc acc tcc acc gac tgg aag gag gcg      345
 Met Ala Ala Lys Val Asp Leu Ser Thr Ser Thr Asp Trp Lys Glu Ala
      85                  90                  95

 aaa tcc ttt ctg aag ggc ctg agt gac aag cag cgg gag gaa cat tac      393
 Lys Ser Phe Leu Lys Gly Leu Ser Asp Lys Gln Arg Glu Glu His Tyr
 100                 105                 110                 115

 ttc tgc aag gac ttt gtc agg ctg aag aag atc ccg aca tgg aag gag      441
 Phe Cys Lys Asp Phe Val Arg Leu Lys Lys Ile Pro Thr Trp Lys Glu
                 120                 125                 130

 atg gcg aaa ggg gtg gct gtg aag gtg gag gag ccc agg tat aaa aag      489
 Met Ala Lys Gly Val Ala Val Lys Val Glu Glu Pro Arg Tyr Lys Lys
             135                 140                 145

 gac aag cag ctc aat gag aaa atc tcc ctg ctc cgc agc gac atc acc      537
 Asp Lys Gln Leu Asn Glu Lys Ile Ser Leu Leu Arg Ser Asp Ile Thr
         150                 155                 160

 aag ctg gag gtg gac gcc atc gtc aac gcc gcc aac agc tcc ctg ctc      585
 Lys Leu Glu Val Asp Ala Ile Val Asn Ala Ala Asn Ser Ser Leu Leu
     165                 170                 175

 gga ggc ggt ggc gtg gac ggc tgc att cat cgg gcc gcc ggc ccc ctg      633
 Gly Gly Gly Gly Val Asp Gly Cys Ile His Arg Ala Ala Gly Pro Leu
 180                 185                 190                 195

 ctt acc gac gag tgc cgg acc ctg cag agc tgt aag act ggc aag gcc      681
 Leu Thr Asp Glu Cys Arg Thr Leu Gln Ser Cys Lys Thr Gly Lys Ala
                 200                 205                 210

 aag atc acc ggc ggc tat cgg ctc ccg gcc aag tac gtc atc cac aca      729
 Lys Ile Thr Gly Gly Tyr Arg Leu Pro Ala Lys Tyr Val Ile His Thr
             215                 220                 225

 gtg ggg ccc atc gcc tac ggg gag ccc agc gcc agt cag gct gcc gag      777
 Val Gly Pro Ile Ala Tyr Gly Glu Pro Ser Ala Ser Gln Ala Ala Glu
         230                 235                 240

 ctc cgc agc tgc tac ctg agc agt ctg gac ctg ctg ctg gag cac cgg      825
 Leu Arg Ser Cys Tyr Leu Ser Ser Leu Asp Leu Leu Leu Glu His Arg
     245                 250                 255

 ctc cgc tcg gtg gcg ttc ccc tgc atc tcc acc ggc gtg ttt ggc tac      873
 Leu Arg Ser Val Ala Phe Pro Cys Ile Ser Thr Gly Val Phe Gly Tyr
 260                 265                 270                 275

 ccc tgt gag gcg gcc gcc gag atc gtg ctg gcc acg ctg cga gag tgg      921
 Pro Cys Glu Ala Ala Ala Glu Ile Val Leu Ala Thr Leu Arg Glu Trp
                 280                 285                 290

 ctg gag cag cac aag gac aag gtg gac cgg ctg atc atc tgc gtg ttc      969
 Leu Glu Gln His Lys Asp Lys Val Asp Arg Leu Ile Ile Cys Val Phe
             295                 300                 305

 ctc gag aag gac gag gac atc tac cgg agc cgg ctc ccc cac tac ttc     1017
 Leu Glu Lys Asp Glu Asp Ile Tyr Arg Ser Arg Leu Pro His Tyr Phe
         310                 315                 320

 ccc gtg gcc tga ggc tcccgcagcc caccctgacc gggactgacc cgccttcggg     1072
 Pro Val Ala 
     325

 accccgctcc cagctctgag aggtcgccaa agcctgcagc ctggcctggg cctggccacc   1132

 ccttctttcc ctccgcgccc cgcccccgag gagcctaata aagatctcgt tgtggcagct   1192

 caaaaaaaaa aaa                                                      1205




      <210> 336
      <211> 1595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(1595)

      <400> 336
 gacctggaaa agatctaagg ggtccatgat tccagatttc aggcggggcc acattcaact     60

 atcatttctt ccaaattttt gcagtggaat acaagtttga aacctgggta tctccttaat    120

 tctccatgtg ctgtgaggag atttggcata aattgaacaa ttggacttga gtatttccat    180

 ctaatattaa actaccttaa gtactttggc actgcagaaa tgtaaagcat cccttttatt    240

 tgtcatttct aggggaggta actccaggac tatctcaggt ggaatatgca cttcgcagac    300

 acaaacta atg tct ctg atc cag aag gaa gct caa ggg cag agt ggg aca     350
          Met Ser Leu Ile Gln Lys Glu Ala Gln Gly Gln Ser Gly Thr
            1               5                  10

 gac cag aca gtg gtt gtg ctc tcc aac cct aca tac tac atg agc aac      398
 Asp Gln Thr Val Val Val Leu Ser Asn Pro Thr Tyr Tyr Met Ser Asn
  15                  20                  25                  30

 gat att ccc tat act ttc cac caa gac aac aat ttc ctg tac cta tgt      446
 Asp Ile Pro Tyr Thr Phe His Gln Asp Asn Asn Phe Leu Tyr Leu Cys
                  35                  40                  45

 gga ttc caa gag cct gat agc att ctt gtc ctt cag agc ctc cct ggc      494
 Gly Phe Gln Glu Pro Asp Ser Ile Leu Val Leu Gln Ser Leu Pro Gly
              50                  55                  60

 aaa caa tta cca tca cac aaa gcc ata ctt ttt gtg cct cgg cga gat      542
 Lys Gln Leu Pro Ser His Lys Ala Ile Leu Phe Val Pro Arg Arg Asp
          65                  70                  75

 ccc agt cga gaa ctt tgg gat ggt ccg cga tct ggc act gat gga gca      590
 Pro Ser Arg Glu Leu Trp Asp Gly Pro Arg Ser Gly Thr Asp Gly Ala
      80                  85                  90

 ata gct cta act gga gta gac gaa gcc tat acg cta gaa gaa ttt caa      638
 Ile Ala Leu Thr Gly Val Asp Glu Ala Tyr Thr Leu Glu Glu Phe Gln
  95                 100                 105                 110

 cat ctt cta cca aaa atg aaa gct gag acg aac atg gtt tgg tat gac      686
 His Leu Leu Pro Lys Met Lys Ala Glu Thr Asn Met Val Trp Tyr Asp
                 115                 120                 125

 tgg atg agg ccc tca cat gca cag ctt cac tct gac tat atg cag ccc      734
 Trp Met Arg Pro Ser His Ala Gln Leu His Ser Asp Tyr Met Gln Pro
             130                 135                 140

 ctg act gag gcc aaa gcc aag agc aag aac aag gtt cgg ggt gtt cag      782
 Leu Thr Glu Ala Lys Ala Lys Ser Lys Asn Lys Val Arg Gly Val Gln
         145                 150                 155

 cag ctg ata cag cgc ctc cgg ctg atc aag tct cct gca gaa att gaa      830
 Gln Leu Ile Gln Arg Leu Arg Leu Ile Lys Ser Pro Ala Glu Ile Glu
     160                 165                 170

 cga atg cag att gct ggg aag ctg aca tca cag gct ttc ata gaa acc      878
 Arg Met Gln Ile Ala Gly Lys Leu Thr Ser Gln Ala Phe Ile Glu Thr
 175                 180                 185                 190

 atg ttc acc agt aaa gcc cct gtg gaa gaa gcc ttt ctt tat gct aag      926
 Met Phe Thr Ser Lys Ala Pro Val Glu Glu Ala Phe Leu Tyr Ala Lys
                 195                 200                 205

 ttt gaa ttt gaa tgc cgg gct cgt ggc gca gac att tta gcc tat cca      974
 Phe Glu Phe Glu Cys Arg Ala Arg Gly Ala Asp Ile Leu Ala Tyr Pro
             210                 215                 220

 cct gtg gtg gct ggt ggt aat cgg tca aac act ttg cac tat gtg aaa     1022
 Pro Val Val Ala Gly Gly Asn Arg Ser Asn Thr Leu His Tyr Val Lys
         225                 230                 235

 aat aat caa ctc atc aag gat ggg gaa atg gtg ctt ctg gat gga ggt     1070
 Asn Asn Gln Leu Ile Lys Asp Gly Glu Met Val Leu Leu Asp Gly Gly
     240                 245                 250

 tgt gag tct tcc tgc tat gtg agt gac atc aca cgt acg tgg cca gtc     1118
 Cys Glu Ser Ser Cys Tyr Val Ser Asp Ile Thr Arg Thr Trp Pro Val
 255                 260                 265                 270

 aat ggc agg ttc acc gca cct cag gca gaa ctc tat gaa gcc gtt cta     1166
 Asn Gly Arg Phe Thr Ala Pro Gln Ala Glu Leu Tyr Glu Ala Val Leu
                 275                 280                 285

 gag atc caa aga gat tgt ttg gcc ctc tgc ttc cct ggg aca agc ttg     1214
 Glu Ile Gln Arg Asp Cys Leu Ala Leu Cys Phe Pro Gly Thr Ser Leu
             290                 295                 300

 gag aac atc tac agc atg atg ctg acc ctg ata gga cag aag ctt aaa     1262
 Glu Asn Ile Tyr Ser Met Met Leu Thr Leu Ile Gly Gln Lys Leu Lys
         305                 310                 315

 gac ttg ggg atc atg aag aac att aag gaa aat aat gcc ttc aag gct     1310
 Asp Leu Gly Ile Met Lys Asn Ile Lys Glu Asn Asn Ala Phe Lys Ala
     320                 325                 330

 gct cga aaa tac tgt cct cat cat gtt ggc cac tac ctc ggg atg gat     1358
 Ala Arg Lys Tyr Cys Pro His His Val Gly His Tyr Leu Gly Met Asp
 335                 340                 345                 350

 gtc cat gac act cca gac atg ccc cgt tcc ctc cct ctg cag cct ggg     1406
 Val His Asp Thr Pro Asp Met Pro Arg Ser Leu Pro Leu Gln Pro Gly
                 355                 360                 365

 atg gta atc aca att gag ccc ggc att tat att cca gag gat gac aaa     1454
 Met Val Ile Thr Ile Glu Pro Gly Ile Tyr Ile Pro Glu Asp Asp Lys
             370                 375                 380

 gat gcc cca gag aag ttt cgg ggt ctt ggt gta cga att gag gat gat     1502
 Asp Ala Pro Glu Lys Phe Arg Gly Leu Gly Val Arg Ile Glu Asp Asp
         385                 390                 395

 gta gtg gtg act cag gac tca cct ctc atc ctt tct gca gac tgt ccc     1550
 Val Val Val Thr Gln Asp Ser Pro Leu Ile Leu Ser Ala Asp Cys Pro
     400                 405                 410

 aaa gag atg aat gac att gaa cag ata tgc agc cag gct tct tga         1595
 Lys Glu Met Asn Asp Ile Glu Gln Ile Cys Ser Gln Ala Ser 
 415                 420                 425





      <210> 337
      <211> 903
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (370)..(687)

      <400> 337
 agtcagcgtg gtggaattca ccgggagccg ggtggccggg atggagacgg ctaagccgcg     60

 agaagtttac cttctaccac agcgtccaca gtacccggct tggcctcagg cctcgggtcc    120

 cgacgtcctc cccagagcac aaacctacta cagatgccac tgccgccagg agccctgtaa    180

 catcagccat cgtcaacccc accgtgttct tcaacatcac cgttgacggc aagcctttag    240

 acctgcgtct ccttcaagct gtttgcagac aaggttccaa agccagcaga aaacttttgt    300

 gctctgagca ctggagagaa aggatttggt tataagagtt cctgctttca cagaattatt    360

 ccagggttt    atg tgt cag ggt ggt gac ttc ata cgc cat aat ggc act     408
              Met Cys Gln Gly Gly Asp Phe Ile Arg His Asn Gly Thr
                1               5                  10

 ggt ggc aag tcc atc tat ggg gag aaa ttt gat gat gag aac ttc atc      456
 Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Asp Asp Glu Asn Phe Ile
      15                  20                  25

 cta aag cat aca ggt cct ggc atg ttg tcc atg gca aat gct gga ccc      504
 Leu Lys His Thr Gly Pro Gly Met Leu Ser Met Ala Asn Ala Gly Pro
  30                  35                  40                  45

 aat aca aat ggt tcc cag ttt tta atc tgc act gcc aag act gag tgg      552
 Asn Thr Asn Gly Ser Gln Phe Leu Ile Cys Thr Ala Lys Thr Glu Trp
                  50                  55                  60

 ttg gat ggc aag ctt gtg gtc ttt ggc aaa gtg aaa gaa ggc atg aat      600
 Leu Asp Gly Lys Leu Val Val Phe Gly Lys Val Lys Glu Gly Met Asn
              65                  70                  75

 att gtg gag gcc atg gag cgc ttt ggg tcc agg aat ggc aag acc agc      648
 Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser
          80                  85                  90

 aag aag atc acc att gct gac tgt gga caa ctc gaa taa gtttgacttg       697
 Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu 
      95                 100                 105

 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc    757

 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg    817

 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat    877

 aaaaactaaa taacaaaaaa aaaaaa                                         903




      <210> 338
      <211> 2181
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(1650)

      <400> 338
 ggccctgtca cttctctgat agctcccagc tcgctctctg cagcc    atg att gcc      54
                                                      Met Ile Ala
                                                        1

 aga cag cag tgt gtc cga ggc ggg ccc cgg ggc ttc agc tgt ggc tcg      102
 Arg Gln Gln Cys Val Arg Gly Gly Pro Arg Gly Phe Ser Cys Gly Ser
       5                  10                  15

 gcc att gta ggc ggt ggc aag aga ggt gcc ttc agc tca gtc tcc atg      150
 Ala Ile Val Gly Gly Gly Lys Arg Gly Ala Phe Ser Ser Val Ser Met
  20                  25                  30                  35

 tct gga ggt gct ggc cga tgc tct tct ggg gga ttt ggc agc aga agc      198
 Ser Gly Gly Ala Gly Arg Cys Ser Ser Gly Gly Phe Gly Ser Arg Ser
                  40                  45                  50

 ctc tac aac ctc agg ggg aac aaa agc atc tcc atg agt gtg gct ggg      246
 Leu Tyr Asn Leu Arg Gly Asn Lys Ser Ile Ser Met Ser Val Ala Gly
              55                  60                  65

 tca cga caa ggt gcc tgc ttt ggg ggt gct gga ggc ttt ggc act ggt      294
 Ser Arg Gln Gly Ala Cys Phe Gly Gly Ala Gly Gly Phe Gly Thr Gly
          70                  75                  80

 ggc ttt ggt gcc ggc ggc ttc gga gct ggt ttc ggc act ggt ggc ttt      342
 Gly Phe Gly Ala Gly Gly Phe Gly Ala Gly Phe Gly Thr Gly Gly Phe
      85                  90                  95

 ggt ggt gga ttt ggg ggc tcc ttc agt ggt aag ggt ggc cct ggc ttc      390
 Gly Gly Gly Phe Gly Gly Ser Phe Ser Gly Lys Gly Gly Pro Gly Phe
 100                 105                 110                 115

 ccc gtc tgc ccc gct ggg gga att cag gag gtc acc atc aac cag agc      438
 Pro Val Cys Pro Ala Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Ser
                 120                 125                 130

 ttg ctc acc ccc ctc cac gtg gag att gac cct gag atc cag aaa gtc      486
 Leu Leu Thr Pro Leu His Val Glu Ile Asp Pro Glu Ile Gln Lys Val
             135                 140                 145

 cgg acg gaa gag cgc gaa cag atc aag ctc ctc aac aac aag ttt gcc      534
 Arg Thr Glu Glu Arg Glu Gln Ile Lys Leu Leu Asn Asn Lys Phe Ala
         150                 155                 160

 tcc ttc atc gac aag gtg cag ttc tta gag caa cag aat aag gtc ctg      582
 Ser Phe Ile Asp Lys Val Gln Phe Leu Glu Gln Gln Asn Lys Val Leu
     165                 170                 175

 gag acc aaa tgg aac ctg ctc cag cag cag acg acc acc acc tcc agc      630
 Glu Thr Lys Trp Asn Leu Leu Gln Gln Gln Thr Thr Thr Thr Ser Ser
 180                 185                 190                 195

 aaa aac ctt gag ccc ctc ttt gag acc tac ctc agt gtc ctg agg aag      678
 Lys Asn Leu Glu Pro Leu Phe Glu Thr Tyr Leu Ser Val Leu Arg Lys
                 200                 205                 210

 cag cta gat acc ttg ggc aat gac aaa ggg cgc ctg cag tct gag ctg      726
 Gln Leu Asp Thr Leu Gly Asn Asp Lys Gly Arg Leu Gln Ser Glu Leu
             215                 220                 225

 aag acc atg cag gac agc gtg gag gac ttc aag act aag tat gaa gag      774
 Lys Thr Met Gln Asp Ser Val Glu Asp Phe Lys Thr Lys Tyr Glu Glu
         230                 235                 240

 gag atc aac aaa cgc aca gca gcc gag aat gac ttt gtg gtc cta aag      822
 Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe Val Val Leu Lys
     245                 250                 255

 aag gac gtg gat gct gcc tac ctg aac aag gtg gag ttg gag gcc aag      870
 Lys Asp Val Asp Ala Ala Tyr Leu Asn Lys Val Glu Leu Glu Ala Lys
 260                 265                 270                 275

 gtg gac agt ctt aat gac gag atc aac ttc ctg aag gtc ctc tat gat      918
 Val Asp Ser Leu Asn Asp Glu Ile Asn Phe Leu Lys Val Leu Tyr Asp
                 280                 285                 290

 gcg gag ctg tcc cag atg cag acc cat gtc agc gac acg tcc gtg gtc      966
 Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp Thr Ser Val Val
             295                 300                 305

 ctt tcc atg gac aac aac cgc aac ctg gac ctg gac agc att att gcc     1014
 Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala
         310                 315                 320

 gag gtc cgt gcc cag tac gag gag att gcc cag agg agc aag gct gag     1062
 Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Lys Ala Glu
     325                 330                 335

 gct gaa gcc ctg tac cag acc aag gtc cag cag ctc cag atc tcg gtt     1110
 Ala Glu Ala Leu Tyr Gln Thr Lys Val Gln Gln Leu Gln Ile Ser Val
 340                 345                 350                 355

 gac caa cat ggt gac aac ctg aag aac acc aag agt gaa att gca gag     1158
 Asp Gln His Gly Asp Asn Leu Lys Asn Thr Lys Ser Glu Ile Ala Glu
                 360                 365                 370

 ctc aac agg atg atc cag agg ctg cgg gca gag atc gag aac atc aag     1206
 Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Glu Asn Ile Lys
             375                 380                 385

 aag cag tgc cag act ctt cag gta tcc gtg gct gat gca gag cag cga     1254
 Lys Gln Cys Gln Thr Leu Gln Val Ser Val Ala Asp Ala Glu Gln Arg
         390                 395                 400

 ggt gag aat gcc ctt aaa gat gcc cac agc aag cgc gta gag ctg gag     1302
 Gly Glu Asn Ala Leu Lys Asp Ala His Ser Lys Arg Val Glu Leu Glu
     405                 410                 415

 gct gcc ctg cag cag gcc aag gag gag ctg gca cga atg ctg cgt gag     1350
 Ala Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala Arg Met Leu Arg Glu
 420                 425                 430                 435

 tac cag gag ctc atg agt gtg aag ctg gcc ttg gac atc gag atc gcc     1398
 Tyr Gln Glu Leu Met Ser Val Lys Leu Ala Leu Asp Ile Glu Ile Ala
                 440                 445                 450

 acc tac cgc aaa ctg ctg gag ggc gag gag tac aga atg tct gga gaa     1446
 Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Tyr Arg Met Ser Gly Glu
             455                 460                 465

 tgc cag agt gcc gtg agc atc tct gtg gtc agc ggt agc acc agc act     1494
 Cys Gln Ser Ala Val Ser Ile Ser Val Val Ser Gly Ser Thr Ser Thr
         470                 475                 480

 gga ggc atc agc gga gga tta gga agt ggc tcc ggg ttt ggc ctg agt     1542
 Gly Gly Ile Ser Gly Gly Leu Gly Ser Gly Ser Gly Phe Gly Leu Ser
     485                 490                 495

 agt ggc ttt ggc tcc ggc tct gga agt ggc ttt ggg ttt ggt ggc agt     1590
 Ser Gly Phe Gly Ser Gly Ser Gly Ser Gly Phe Gly Phe Gly Gly Ser
 500                 505                 510                 515

 gtc tct ggc agt tcc agc agc aag atc atc tct acc acc acc ctg aac     1638
 Val Ser Gly Ser Ser Ser Ser Lys Ile Ile Ser Thr Thr Thr Leu Asn
                 520                 525                 530

 aag aga cga tag agg agacgaggtc cctgcagctc actgtgtcca gctgggccca     1693
 Lys Arg Arg 


 gcactggtgt ctctgtgctt ccttcacttc acctccatcc tctgtctctg gggctcatct   1753

 tactagtatc ccctccacta tcccatgggc tctctctgcc ccaggatgat cttctgtgct   1813

 gggacaggga ctctgcctct tggagtttgg tagctacttc ttgatttggg cctggtgacc   1873

 cacctggaat gggaaggatg tcagctgacc tctcacctcc catgggcaga gaagaaaatg   1933

 accaggagtg tcatctccag aattattggg gtcacatatg tcccttccca gtccaatgcc   1993

 atctcccact agatcctgta ttatccatct acatcagaac caaactactt ctccaacacc   2053

 cggcagcact tggccctgca agcttaggat gagaaccact tagtgtccca ttctactcct   2113

 ctcattccct cttatccatc tgcaggtgaa tcttcaataa aatgcttttg tcattcaaaa   2173

 aaaaaaaa                                                            2181




      <210> 339
      <211> 2114
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(1470)

      <400> 339
 aacacctcgg ccagcagcag caggctaccc acacccttca ccacacactc cccacctaca     60

 gggagcagtc ccttctcttc cacaggtcct     atg act gca aca tcc ttc cag     111
                                      Met Thr Ala Thr Ser Phe Gln
                                        1               5

 acc acc act acc tat cca acc cca tca cac cct cag acc aca ctt ccc      159
 Thr Thr Thr Thr Tyr Pro Thr Pro Ser His Pro Gln Thr Thr Leu Pro
          10                  15                  20

 act cac gtt cca cct ttc tcc acc tcc ttg gtg act cca agt act cac      207
 Thr His Val Pro Pro Phe Ser Thr Ser Leu Val Thr Pro Ser Thr His
      25                  30                  35

 aca gtc atc atc act acc cac aca cag atg gcc act tct gcc tcc atc      255
 Thr Val Ile Ile Thr Thr His Thr Gln Met Ala Thr Ser Ala Ser Ile
  40                  45                  50                  55

 cac tca acg cca aca ggc acc gtt cct cca cca aca acg ctc aag gcc      303
 His Ser Thr Pro Thr Gly Thr Val Pro Pro Pro Thr Thr Leu Lys Ala
                  60                  65                  70

 aca ggg tcc acc cac aca gcc cca cca atg aca gtg acc acc agt ggg      351
 Thr Gly Ser Thr His Thr Ala Pro Pro Met Thr Val Thr Thr Ser Gly
              75                  80                  85

 acc agc caa acc cac agc tca ttc agc aca gct aca gcc tct tct tcc      399
 Thr Ser Gln Thr His Ser Ser Phe Ser Thr Ala Thr Ala Ser Ser Ser
          90                  95                 100

 ttc ata tcc tcc tcg tct tgg tcg tct tgg ctg cct cag aac tct agc      447
 Phe Ile Ser Ser Ser Ser Trp Ser Ser Trp Leu Pro Gln Asn Ser Ser
     105                 110                 115

 tca agg cca ccg tca tca cct atc acc aca caa ctc ccc cac ttg agt      495
 Ser Arg Pro Pro Ser Ser Pro Ile Thr Thr Gln Leu Pro His Leu Ser
 120                 125                 130                 135

 tct gca acc act cct gtt tcc aca act aat cag ctg tcc tcc tca ttt      543
 Ser Ala Thr Thr Pro Val Ser Thr Thr Asn Gln Leu Ser Ser Ser Phe
                 140                 145                 150

 tct ccc agt cct tct gcc ccc tct act gtt tct tct tat gtg ccc tcc      591
 Ser Pro Ser Pro Ser Ala Pro Ser Thr Val Ser Ser Tyr Val Pro Ser
             155                 160                 165

 tcc cac tcc tct ccc cag act tca tcg cct tct gtt ggc aca tct tcc      639
 Ser His Ser Ser Pro Gln Thr Ser Ser Pro Ser Val Gly Thr Ser Ser
         170                 175                 180

 tct ttc gtg tcc gcc ccc gtg cac tcc aca acc ctg agc tcg ggg tca      687
 Ser Phe Val Ser Ala Pro Val His Ser Thr Thr Leu Ser Ser Gly Ser
     185                 190                 195

 cac tcc tca ttg tcc act cat ccc acg act gga tca ggg tct gca tct      735
 His Ser Ser Leu Ser Thr His Pro Thr Thr Gly Ser Gly Ser Ala Ser
 200                 205                 210                 215

 cct ctt ttt cct tct tct cca gct gcc tct act acc att agg gcc act      783
 Pro Leu Phe Pro Ser Ser Pro Ala Ala Ser Thr Thr Ile Arg Ala Thr
                 220                 225                 230

 ctc ccc cac act atc tcc tct cct ttc acc ctc tct gct cta ctc ccc      831
 Leu Pro His Thr Ile Ser Ser Pro Phe Thr Leu Ser Ala Leu Leu Pro
             235                 240                 245

 ata tcc act gtt acc gtg tct ccc acc cca tcc agc cac cta gcc tcc      879
 Ile Ser Thr Val Thr Val Ser Pro Thr Pro Ser Ser His Leu Ala Ser
         250                 255                 260

 agc acc att gca ttt ccg tcc acg ccc agg acc acg gcc agc acc cac      927
 Ser Thr Ile Ala Phe Pro Ser Thr Pro Arg Thr Thr Ala Ser Thr His
     265                 270                 275

 acc gcc cct gcc ttc tcc tct cag tcc acc acc tcg cgg tcc act tct      975
 Thr Ala Pro Ala Phe Ser Ser Gln Ser Thr Thr Ser Arg Ser Thr Ser
 280                 285                 290                 295

 ctc acc acc cga gtt ccc aca tca ggc ttt gtg tca ctc acc tcg ggg     1023
 Leu Thr Thr Arg Val Pro Thr Ser Gly Phe Val Ser Leu Thr Ser Gly
                 300                 305                 310

 gtg acg ggt atc ccc acc tct cca gtc acc aac ctt acc acc agg cac     1071
 Val Thr Gly Ile Pro Thr Ser Pro Val Thr Asn Leu Thr Thr Arg His
             315                 320                 325

 cct ggt ccc acc ttg tcg cct acc aca cgg ttc ctg acc agc tcc ctc     1119
 Pro Gly Pro Thr Leu Ser Pro Thr Thr Arg Phe Leu Thr Ser Ser Leu
         330                 335                 340

 act gcc cat gga agc acc cct gct tct gcc ccg gta tct tct ctc ggg     1167
 Thr Ala His Gly Ser Thr Pro Ala Ser Ala Pro Val Ser Ser Leu Gly
     345                 350                 355

 aca cct acg ccc acc tca ccc ggg gtc tgc agt gtg cgg gag cag cag     1215
 Thr Pro Thr Pro Thr Ser Pro Gly Val Cys Ser Val Arg Glu Gln Gln
 360                 365                 370                 375

 gag gag atc acg ttc aag ggg tgc atg gcg aac gtg acg gta acc cgc     1263
 Glu Glu Ile Thr Phe Lys Gly Cys Met Ala Asn Val Thr Val Thr Arg
                 380                 385                 390

 tgt gag ggc gcc tgc att tcc gct gcc agc ttc aac atc atc acc cag     1311
 Cys Glu Gly Ala Cys Ile Ser Ala Ala Ser Phe Asn Ile Ile Thr Gln
             395                 400                 405

 cag gtg gat gcc cgc tgc agc tgc tgc cgc ccc ctc cac tcc tat gag     1359
 Gln Val Asp Ala Arg Cys Ser Cys Cys Arg Pro Leu His Ser Tyr Glu
         410                 415                 420

 cag cag ctg gag ctg ccc tgc ccc gat ccc agc acg cct ggc cgg cgg     1407
 Gln Gln Leu Glu Leu Pro Cys Pro Asp Pro Ser Thr Pro Gly Arg Arg
     425                 430                 435

 ctc gta ctc acc ctg cag gtg ttc agc cac tgc gtg tgc agc tct gtg     1455
 Leu Val Leu Thr Leu Gln Val Phe Ser His Cys Val Cys Ser Ser Val
 440                 445                 450                 455

 gcc tgt gga gac tag cagggtcgct gcctgctctc ctggggctga aggactgcag     1510
 Ala Cys Gly Asp 


 atgacagaca ggaaaacacc caccagcccc cttcccgctt gtgccagcag ctgctttcct   1570

 ggtcaccagg cctggccccc aagtgccctg ggccgtggct ccctggggca ccggttggag   1630

 aggggctgcc aagcaggggc tcagactacc acactcctgc agaccctgag ccagcagaga   1690

 gggactgagg cggacagtgg tcacggacct cccaggcaca cagggcactc ccgaccaccc   1750

 ctgcccactg tccaacacct cccagcccct gaacttggcc ccagccctgc tgggcccaga   1810

 accctgcaga tgaagccaca gagcaggcgc tcgaccagac ccatcagggg cgaggagggc   1870

 acggaaacct gtgccgagat gggggcaaga ggcccaggca gccaccagca cagagaagag   1930

 gagatcccca gagtcaggga gggcagaggg tggcagcgag ggcagggcag ccgcccccgc   1990

 tcccagccag gcagaaggcc cccaccagca ccacacccat ccccagcagc ctgtccttgg   2050

 gagagggcgt cacccggtca gagactccaa ataaaccggt tcttgtcaag gcaaaaaaaa   2110

 aaaa                                                                2114




      <210> 340
      <211> 1597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(1312)

      <400> 340
 agacctcgac cttcacagga ctcttcattg ctggttggca  atg atg tat cgg cca      55
                                              Met Met Tyr Arg Pro
                                                1               5

 gat gtg gtg agg gct agg aaa aga gtt tgt tgg gaa ccc tgg gtt atc      103
 Asp Val Val Arg Ala Arg Lys Arg Val Cys Trp Glu Pro Trp Val Ile
                  10                  15                  20

 ggc ctc gtc atc ttc ata tcc ctg att gtc ctg gca gtg tgc att gga      151
 Gly Leu Val Ile Phe Ile Ser Leu Ile Val Leu Ala Val Cys Ile Gly
              25                  30                  35

 ctc act gtt cat tat gtg aga tat aat caa aag aag acc tac aat tac      199
 Leu Thr Val His Tyr Val Arg Tyr Asn Gln Lys Lys Thr Tyr Asn Tyr
          40                  45                  50

 tat agc aca ttg tca ttt aca act gac aaa cta tat gct gag ttt ggc      247
 Tyr Ser Thr Leu Ser Phe Thr Thr Asp Lys Leu Tyr Ala Glu Phe Gly
      55                  60                  65

 aga gag gct tct aac aat ttt aca gaa atg agc cag aga ctt gaa tca      295
 Arg Glu Ala Ser Asn Asn Phe Thr Glu Met Ser Gln Arg Leu Glu Ser
  70                  75                  80                  85

 atg gtg aaa aat gca ttt tat aaa tct cca tta agg gaa gaa ttt gtc      343
 Met Val Lys Asn Ala Phe Tyr Lys Ser Pro Leu Arg Glu Glu Phe Val
                  90                  95                 100

 aag tct cag gtt atc aag ttc agt caa cag aag cat gga gtg ttg gct      391
 Lys Ser Gln Val Ile Lys Phe Ser Gln Gln Lys His Gly Val Leu Ala
             105                 110                 115

 cat atg ctg ttg att tgt aga ttt cac tct act gag gat cct gaa act      439
 His Met Leu Leu Ile Cys Arg Phe His Ser Thr Glu Asp Pro Glu Thr
         120                 125                 130

 gta gat aaa att gtt caa ctt gtt tta cat gaa aag ctg caa gat gct      487
 Val Asp Lys Ile Val Gln Leu Val Leu His Glu Lys Leu Gln Asp Ala
     135                 140                 145

 gta gga ccc cct aaa gta gat cct cac tca gtt aaa att aaa aaa atc      535
 Val Gly Pro Pro Lys Val Asp Pro His Ser Val Lys Ile Lys Lys Ile
 150                 155                 160                 165

 aac aag aca gaa aca gac agc tat cta aac cat tgc tgc gga aca cga      583
 Asn Lys Thr Glu Thr Asp Ser Tyr Leu Asn His Cys Cys Gly Thr Arg
                 170                 175                 180

 aga agt aaa act cta ggt cag agt ctc agg atc gtt ggt ggg aca gaa      631
 Arg Ser Lys Thr Leu Gly Gln Ser Leu Arg Ile Val Gly Gly Thr Glu
             185                 190                 195

 gta gaa gag ggt gaa tgg ccc tgg cag gct agc ctg cag tgg gat ggg      679
 Val Glu Glu Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Trp Asp Gly
         200                 205                 210

 agt cat cgc tgt gga gca acc tta att aat gcc aca tgg ctt gtg agt      727
 Ser His Arg Cys Gly Ala Thr Leu Ile Asn Ala Thr Trp Leu Val Ser
     215                 220                 225

 gct gct cac tgt ttt aca aca tat aag aac cct gcc aga tgg act gct      775
 Ala Ala His Cys Phe Thr Thr Tyr Lys Asn Pro Ala Arg Trp Thr Ala
 230                 235                 240                 245

 tcc ttt gga gta aca ata aaa cct tcg aaa atg aaa cgg ggt ctc cgg      823
 Ser Phe Gly Val Thr Ile Lys Pro Ser Lys Met Lys Arg Gly Leu Arg
                 250                 255                 260

 aga ata att gtc cat gaa aaa tac aaa cac cca tca cat gac tat gat      871
 Arg Ile Ile Val His Glu Lys Tyr Lys His Pro Ser His Asp Tyr Asp
             265                 270                 275

 att tct ctt gca gag ctt tct agc cct gtt ccc tac aca aat gca gta      919
 Ile Ser Leu Ala Glu Leu Ser Ser Pro Val Pro Tyr Thr Asn Ala Val
         280                 285                 290

 cat aga gtt tgt ctc cct gat gca tcc tat gag ttt caa cca ggt gat      967
 His Arg Val Cys Leu Pro Asp Ala Ser Tyr Glu Phe Gln Pro Gly Asp
     295                 300                 305

 gtg atg ttt gtg aca gga ttt gga gca ctg aaa aat gat ggt tac agt     1015
 Val Met Phe Val Thr Gly Phe Gly Ala Leu Lys Asn Asp Gly Tyr Ser
 310                 315                 320                 325

 caa aat cat ctt cga caa gca cag gtg act ctc ata gac gct aca act     1063
 Gln Asn His Leu Arg Gln Ala Gln Val Thr Leu Ile Asp Ala Thr Thr
                 330                 335                 340

 tgc aat gaa cct caa gct tac aat gac gcc ata act cct aga atg tta     1111
 Cys Asn Glu Pro Gln Ala Tyr Asn Asp Ala Ile Thr Pro Arg Met Leu
             345                 350                 355

 tgt gct ggc tcc tta gaa gga aaa aca gat gca tgc cag ggt gac tct     1159
 Cys Ala Gly Ser Leu Glu Gly Lys Thr Asp Ala Cys Gln Gly Asp Ser
         360                 365                 370

 gga gga cca ctg gtt agt tca gat gct aga gat atc tgg tac ctt gct     1207
 Gly Gly Pro Leu Val Ser Ser Asp Ala Arg Asp Ile Trp Tyr Leu Ala
     375                 380                 385

 gga ata gtg agc tgg gga gat gaa tgt gcg aaa ccc aac aag cct ggt     1255
 Gly Ile Val Ser Trp Gly Asp Glu Cys Ala Lys Pro Asn Lys Pro Gly
 390                 395                 400                 405

 gtt tat act aga gtt acg gcc ttg cgg gac tgg att act tca aaa act     1303
 Val Tyr Thr Arg Val Thr Ala Leu Arg Asp Trp Ile Thr Ser Lys Thr
                 410                 415                 420

 ggt atc taa gagagaa aagcctcatg gaacagataa catttttttt tgttttttgg     1359
 Gly Ile 


 gtgtggaggc catttttaga gatacagaat tggagaagac ttgcaaaaca gctagatttg   1419

 actgatctca ataaactgtt tgcttgatgc atgtattttc ttcccagctc tgttccgcac   1479

 ataagcatcc tgcttctgcc agatcaactc tgtcatctgt gagcaatagt tgaaacttta   1539

 tgtacataga gaaatagata atacaatatt acattacagc ctgtaaaaaa aaaaaaaa     1597




      <210> 341
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(376)

      <400> 341
 tagcgcttgg aattctcgat gctctccgag tctgtgctga gcacaacgca gctccgccct     60

 cgcaaaggca cagcgcgggc gc atg cgc cca gag gcg cac agg aga cct cag     112
                          Met Arg Pro Glu Ala His Arg Arg Pro Gln
                            1               5                  10

 gcc cag act cca ctc ccc agc tgt gaa agg act gct ggc cag acc ccc      160
 Ala Gln Thr Pro Leu Pro Ser Cys Glu Arg Thr Ala Gly Gln Thr Pro
                  15                  20                  25

 aag cta gcc cgc cag gcc tcc ata gag ctg ccc agc atg gct gca tcc      208
 Lys Leu Ala Arg Gln Ala Ser Ile Glu Leu Pro Ser Met Ala Ala Ser
              30                  35                  40

 agt acc aag agt tgg tgg gag acg ggt gag gta cag gct cag tct gcg      256
 Ser Thr Lys Ser Trp Trp Glu Thr Gly Glu Val Gln Ala Gln Ser Ala
          45                  50                  55

 gcc aag act ccg tcc tgc aag gat att gtg gct gga gac atg agc aag      304
 Ala Lys Thr Pro Ser Cys Lys Asp Ile Val Ala Gly Asp Met Ser Lys
      60                  65                  70

 aaa agc ctc tgg gag cag aag gga ggc tcc aag acc tca tca aca att      352
 Lys Ser Leu Trp Glu Gln Lys Gly Gly Ser Lys Thr Ser Ser Thr Ile
  75                  80                  85                  90

 aag atg gac tct gtg act aca tga ctaataaaat atggcagaaa tgacaccatg     406
 Lys Met Asp Ser Val Thr Thr 
                  95

 cagtttccaa gcccaggcct taggagacag gcagcttcca gttcagtctt ttggagggtc    466

 agctctgggg ccctcagcca tcacgcatgg agtccaacca ccctgagacg tcatgctgga    526

 gacccacctg tggatgcccc agtcaagagt cctggctgag cccagcctcc cagccacccc    586

 cacccaaggc atcagaccac gaagcttctg gccaaggctt caccaacttc acttgatgct    646

 gtgaggaaca gaactgccca tccaagccct gccagaattt ctaaccacaa agccatgagt    706

 ca                                                                   708




      <210> 342
      <211> 1690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(1318)

      <400> 342
 agcaactcgg cagcggacca ag atg gcg gcg ccc tgt gag gga caa gcg ttt      52
                          Met Ala Ala Pro Cys Glu Gly Gln Ala Phe
                            1               5                  10

 gcc gta ggg gtt gaa aag aat tgg ggt gca gta gtt cgc tcc cca gaa      100
 Ala Val Gly Val Glu Lys Asn Trp Gly Ala Val Val Arg Ser Pro Glu
                  15                  20                  25

 ggg acc ccc cag aaa atc cgg cag ctg ata gat gag ggg att gcc ccg      148
 Gly Thr Pro Gln Lys Ile Arg Gln Leu Ile Asp Glu Gly Ile Ala Pro
              30                  35                  40

 gaa gag gga ggc gtg gac gcg aag gac acg tct gcc aca tcc cag tca      196
 Glu Glu Gly Gly Val Asp Ala Lys Asp Thr Ser Ala Thr Ser Gln Ser
          45                  50                  55

 gtt aat gga tca ccc caa gcg gaa caa cct tca ttg gaa tct aca agc      244
 Val Asn Gly Ser Pro Gln Ala Glu Gln Pro Ser Leu Glu Ser Thr Ser
      60                  65                  70

 aaa gaa gcc ttc ttt agc aga gtg gaa aca ttt tct tct ttg aaa tgg      292
 Lys Glu Ala Phe Phe Ser Arg Val Glu Thr Phe Ser Ser Leu Lys Trp
  75                  80                  85                  90

 gca ggt aag ccc ttt gag ctg tct cca ctc gtc tgt gca aaa tat ggc      340
 Ala Gly Lys Pro Phe Glu Leu Ser Pro Leu Val Cys Ala Lys Tyr Gly
                  95                 100                 105

 tgg gtc aca gtg gaa tgt gat atg ctc aag tgc tct agc tgt caa gct      388
 Trp Val Thr Val Glu Cys Asp Met Leu Lys Cys Ser Ser Cys Gln Ala
             110                 115                 120

 ttt ctc tgt gcc agt tta caa cca gct ttt gac ttt gac aga tat aag      436
 Phe Leu Cys Ala Ser Leu Gln Pro Ala Phe Asp Phe Asp Arg Tyr Lys
         125                 130                 135

 caa cga tgt gct gag ctg aag aaa gcc ttg tgt act gcc cat gag aag      484
 Gln Arg Cys Ala Glu Leu Lys Lys Ala Leu Cys Thr Ala His Glu Lys
     140                 145                 150

 ttc tgt ttc tgg cca gac agc cca tcc cca gac cga ttt ggg atg ttg      532
 Phe Cys Phe Trp Pro Asp Ser Pro Ser Pro Asp Arg Phe Gly Met Leu
 155                 160                 165                 170

 ccc ctg gat gag cct gct att ctt gtt agt gaa ttc cta gat cgg ttt      580
 Pro Leu Asp Glu Pro Ala Ile Leu Val Ser Glu Phe Leu Asp Arg Phe
                 175                 180                 185

 tca aag cct ttg tca ctt gga cct cca gct tcc ttc cct aag gcc gga      628
 Ser Lys Pro Leu Ser Leu Gly Pro Pro Ala Ser Phe Pro Lys Ala Gly
             190                 195                 200

 gga ctt gaa aac tat gtg ctt gac aga aga caa gat cag tct tct cct      676
 Gly Leu Glu Asn Tyr Val Leu Asp Arg Arg Gln Asp Gln Ser Ser Pro
         205                 210                 215

 aca ctg ctt gaa gat gaa ctt gat cac cga act gat gag aga aaa act      724
 Thr Leu Leu Glu Asp Glu Leu Asp His Arg Thr Asp Glu Arg Lys Thr
     220                 225                 230

 aca atc aaa tta ggc tca gac atc caa gtc cac gtc act gcc tgt att      772
 Thr Ile Lys Leu Gly Ser Asp Ile Gln Val His Val Thr Ala Cys Ile
 235                 240                 245                 250

 ctc tct gtg tgt ggc tgg gcg tgt agt tcc tct ttg gaa tcc atg cag      820
 Leu Ser Val Cys Gly Trp Ala Cys Ser Ser Ser Leu Glu Ser Met Gln
                 255                 260                 265

 ctc tcc ctg ata gca tgt tcg caa tgt atg agg agg gtg ggg ctc tgg      868
 Leu Ser Leu Ile Ala Cys Ser Gln Cys Met Arg Arg Val Gly Leu Trp
             270                 275                 280

 ggc ttc cag cag att gaa tcg tcc atg act gac ctg gat gca tcc ttt      916
 Gly Phe Gln Gln Ile Glu Ser Ser Met Thr Asp Leu Asp Ala Ser Phe
         285                 290                 295

 ggc ctg acc agc tcc cca atc cca ggc ctt gag ggg cga cca gag cgc      964
 Gly Leu Thr Ser Ser Pro Ile Pro Gly Leu Glu Gly Arg Pro Glu Arg
     300                 305                 310

 tta cct ctg gtg cct gaa tct cct cgg agg atg atg acc cgg agc cag     1012
 Leu Pro Leu Val Pro Glu Ser Pro Arg Arg Met Met Thr Arg Ser Gln
 315                 320                 325                 330

 gat gcc act ttc tcc cca ggc tca gag cag gac aca tct tcc cga agc     1060
 Asp Ala Thr Phe Ser Pro Gly Ser Glu Gln Asp Thr Ser Ser Arg Ser
                 335                 340                 345

 ttc ttt gat ccc acc tct cag cat aga gac tgg tgc cct tgg gtg aat     1108
 Phe Phe Asp Pro Thr Ser Gln His Arg Asp Trp Cys Pro Trp Val Asn
             350                 355                 360

 atc aca ctt ggc aaa gaa agc agg gag aat ggt gga act gaa cca gat     1156
 Ile Thr Leu Gly Lys Glu Ser Arg Glu Asn Gly Gly Thr Glu Pro Asp
         365                 370                 375

 gcc agc gcc cca gca gag cca ggc tgg aaa gca gtg ctg acc atc ctc     1204
 Ala Ser Ala Pro Ala Glu Pro Gly Trp Lys Ala Val Leu Thr Ile Leu
     380                 385                 390

 ttg gcg cac aaa cag tct agc cag cca gct gaa acg gac tcc atg agt     1252
 Leu Ala His Lys Gln Ser Ser Gln Pro Ala Glu Thr Asp Ser Met Ser
 395                 400                 405                 410

 ctc tct gag aaa tca agg aaa gta ttc cga ata ttt cgg cag tgg gaa     1300
 Leu Ser Glu Lys Ser Arg Lys Val Phe Arg Ile Phe Arg Gln Trp Glu
                 415                 420                 425

 tct ctg tgc tca tgc tga aagata ctccagcgcc ttcctggaga tagctggaat     1354
 Ser Leu Cys Ser Cys 
             430

 gagagtgact ttttgaaaaa ttaaggctga gttcctttcg gtcagctgac actaagtttt   1414

 tcctgttctg ggttaatcat aaggagcccc ctgccatagc aaaggcagtg agtgtcaact   1474

 atctgcatct ggctgagaga gacccgtttc ctttcaggga tgtggacagg gtaagggcag   1534

 caagcatggt tctgttaaag gagtgtgggg ttaacagact agaaggaaga ctaaggacct   1594

 gaccacccat ttcagcatct tcaatgtgga gcagtgttct gaggactctt ctatcctagg   1654

 actatgacag tgtgtattaa taaaatattt gctaag                             1690




      <210> 343
      <211> 935
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (322)..(885)

      <400> 343
 cccattttga tagctgttac gcctgcacgt accggtccgg aattcccggg tcgaggattt     60

 gtctattgag ttgcagttaa aatgatggcg aaaaatgctt ttgtttcagt tctgcagatg    120

 gtctgggagg ttgtgtttct tagcaagaat tttctagacg ttttggcttg aaccatctga    180

 aaaactgcct caagcttttg catggttccc actgggtggg ctgggttggg aggggctgtc    240

 gtgcatggtc cgggaaagct ggagaaggct gttccttcac cccgagcctt ggatttctta    300

 tctgtgaaat gggaggctgc a  atg atg aat ggc aaa gta cct ttt ttt ttc     351
                          Met Met Asn Gly Lys Val Pro Phe Phe Phe
                            1               5                  10

 agc tct gaa agt cta gga tat ttt gcc act gga aga cca gca gac aat      399
 Ser Ser Glu Ser Leu Gly Tyr Phe Ala Thr Gly Arg Pro Ala Asp Asn
                  15                  20                  25

 gtc atg aca act caa gag gat aca aca ggg ctg cat caa aag aca agt      447
 Val Met Thr Thr Gln Glu Asp Thr Thr Gly Leu His Gln Lys Thr Ser
              30                  35                  40

 ctt tgg acc atg tca aga cct gga gcg aag aag gta atg aac tcc tac      495
 Leu Trp Thr Met Ser Arg Pro Gly Ala Lys Lys Val Met Asn Ser Tyr
          45                  50                  55

 ttc ata gca ggc tgt ggg cca gca gtt tgc tac tac gct gtc tct tgg      543
 Phe Ile Ala Gly Cys Gly Pro Ala Val Cys Tyr Tyr Ala Val Ser Trp
      60                  65                  70

 tta agg caa ggt ttc agt atc aac ctg act tct ttt gga agg atc cct      591
 Leu Arg Gln Gly Phe Ser Ile Asn Leu Thr Ser Phe Gly Arg Ile Pro
  75                  80                  85                  90

 tgg cct cac gct gga gtg ggc acc tgc cct agc cca cag agc tgg att      639
 Trp Pro His Ala Gly Val Gly Thr Cys Pro Ser Pro Gln Ser Trp Ile
                  95                 100                 105

 tct ccc ttt ctt caa tca cac agg gag cac cac tat gca aag acc tca      687
 Ser Pro Phe Leu Gln Ser His Arg Glu His His Tyr Ala Lys Thr Ser
             110                 115                 120

 tca cat tca cag ccg tct ccg cag agc ctc gca ctg tgc ttg gca tat      735
 Ser His Ser Gln Pro Ser Pro Gln Ser Leu Ala Leu Cys Leu Ala Tyr
         125                 130                 135

 agc agg tgc tca ata aat atc tgc caa atg act gaa tgc atc tcg cta      783
 Ser Arg Cys Ser Ile Asn Ile Cys Gln Met Thr Glu Cys Ile Ser Leu
     140                 145                 150

 gcc tca gga tgc cac cag gcc ctg agg gag cca gga aga tca gag gaa      831
 Ala Ser Gly Cys His Gln Ala Leu Arg Glu Pro Gly Arg Ser Glu Glu
 155                 160                 165                 170

 agc ttt tgg att cct gcc aca cct tac att agc aac atc ttc tcc gag      879
 Ser Phe Trp Ile Pro Ala Thr Pro Tyr Ile Ser Asn Ile Phe Ser Glu
                 175                 180                 185

 tcc tga cagccagcct cctgggacac cattcaagcc agctgaattc cggtcaccgc       935
 Ser 






      <210> 344
      <211> 1236
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(888)

      <400> 344
 atttggccct cgaggcaaga attcggcacg aggttgttct gtgagcagat aaaaagtaca     60

 tatacagttc atacaataat cttatgtatg taaaaccccg ttacg    atg tcg gcg     114
                                                      Met Ser Ala
                                                        1

 acg ggg ccc atc agt aac tat tac gtg gac tcg ctc atc tct cac gac      162
 Thr Gly Pro Ile Ser Asn Tyr Tyr Val Asp Ser Leu Ile Ser His Asp
       5                  10                  15

 aat gaa gac ctc cta gcg tcc agg ttt ccg gcc acc ggg gct cat ccc      210
 Asn Glu Asp Leu Leu Ala Ser Arg Phe Pro Ala Thr Gly Ala His Pro
  20                  25                  30                  35

 gcc gcc gcc aga ccc agc ggt ttg gtg ccg gac tgt agc gat ttt ccg      258
 Ala Ala Ala Arg Pro Ser Gly Leu Val Pro Asp Cys Ser Asp Phe Pro
                  40                  45                  50

 tcc tgt agc ttc gcg ccc aag ccg gca gtg ttc agc acg tcg tgg gcg      306
 Ser Cys Ser Phe Ala Pro Lys Pro Ala Val Phe Ser Thr Ser Trp Ala
              55                  60                  65

 ccc gtg ccc tct cag tcg tcc gtg gta tat cac ccg tac ggc ccc cag      354
 Pro Val Pro Ser Gln Ser Ser Val Val Tyr His Pro Tyr Gly Pro Gln
          70                  75                  80

 ccc cac ctc ggc gcc gac acg cgc tac atg cgg act tgg ctc gag ccg      402
 Pro His Leu Gly Ala Asp Thr Arg Tyr Met Arg Thr Trp Leu Glu Pro
      85                  90                  95

 ctg tcc ggc gcc gtc tcc ttc ccc agc ttc ccg gcc ggg ggc cgt cac      450
 Leu Ser Gly Ala Val Ser Phe Pro Ser Phe Pro Ala Gly Gly Arg His
 100                 105                 110                 115

 tac gcc ctc aag ccg gac gcc tac ccc ggg cgc cgc gcg gac tgc ggc      498
 Tyr Ala Leu Lys Pro Asp Ala Tyr Pro Gly Arg Arg Ala Asp Cys Gly
                 120                 125                 130

 cca ggg gag ggc cgc agc tac ccg gac tac atg tac ggc tcg ccc ggg      546
 Pro Gly Glu Gly Arg Ser Tyr Pro Asp Tyr Met Tyr Gly Ser Pro Gly
             135                 140                 145

 gag ctg cgc gac cgc gcc ccg cag aca ctg ccc tcg ccc gag gcg gac      594
 Glu Leu Arg Asp Arg Ala Pro Gln Thr Leu Pro Ser Pro Glu Ala Asp
         150                 155                 160

 gcg ctc gcc ggc agc aag cac aaa gag gag aag gct gac ctg gac ccc      642
 Ala Leu Ala Gly Ser Lys His Lys Glu Glu Lys Ala Asp Leu Asp Pro
     165                 170                 175

 agc aac ccc gtg gcc aac tgg att cac gcc cgc tcc acg agg aag aag      690
 Ser Asn Pro Val Ala Asn Trp Ile His Ala Arg Ser Thr Arg Lys Lys
 180                 185                 190                 195

 cgc tgc ccc tac acc aag tac cag acg ctg gaa ctg gag aag gag ttt      738
 Arg Cys Pro Tyr Thr Lys Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe
                 200                 205                 210

 ctc ttc aat atg tat tta acc agg gac cgt cgg tat gag gtg gcc cgg      786
 Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg Arg Tyr Glu Val Ala Arg
             215                 220                 225

 gtt ctc aat ctc acc gag cgg cag gtc aaa atc tgg ttt cag aat cga      834
 Val Leu Asn Leu Thr Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg
         230                 235                 240

 agg atg aag atg aaa aag atg aat aaa gag aaa acc gac aag gag cag      882
 Arg Met Lys Met Lys Lys Met Asn Lys Glu Lys Thr Asp Lys Glu Gln
     245                 250                 255

 tcc taa accctaccca gcctgctgcc tcagcacagc caagggaaaa acaaaaaccc       938
 Ser 
 260

 cacaaaatac cccaacacag gcgggggaga gacgaaaaag aaaaggaaag agcaagatag    998

 acaaaagcca atcagcttaa aaagaaaaac aaggaagggg aaaagaaaac tcttgcgatt   1058

 tgggagggtt cagtgttgag atattggtgt tttagagtta gttctaccca gcgaggagga   1118

 ggcggggaga gaaactgcgt tctctttccc cagcgcaacc gaaataaatg acacatacaa   1178

 atgtgatttt tttcctcctt tcttcagaga agccagtact tgaatcgcta tatttcta     1236




      <210> 345
      <211> 3637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(3324)

      <400> 345
 agctccggaa ttcccgggtc gacttcgctg tcgacgattt cgtatataaa gcttcggcat     60

 ggtcaagact atcattttct ttgtaaagct tgtaatcttt attcattgag caaagaagga    120
                                                                 
 atg gag aaa cac att aaa aga agc aag cat ctt gaa aat gct aag aaa      168
 Met Glu Lys His Ile Lys Arg Ser Lys His Leu Glu Asn Ala Lys Lys
   1               5                  10                  15

 aat aat att ggc tta agc ttt gaa gaa tgt att gaa agg gta tgt ata      216
 Asn Asn Ile Gly Leu Ser Phe Glu Glu Cys Ile Glu Arg Val Cys Ile
              20                  25                  30

 ggt gca aat gat aaa aaa gaa gag ttt gat gtt tcc gga aat gga agg      264
 Gly Ala Asn Asp Lys Lys Glu Glu Phe Asp Val Ser Gly Asn Gly Arg
          35                  40                  45

 att gaa ggc cat ata ggt gtg caa tta caa gag cat tcc tat ctt gag      312
 Ile Glu Gly His Ile Gly Val Gln Leu Gln Glu His Ser Tyr Leu Glu
      50                  55                  60

 aag ggc atg ctg gcg tct gag gaa ctg tca cag tct ggt ggt agc acc      360
 Lys Gly Met Leu Ala Ser Glu Glu Leu Ser Gln Ser Gly Gly Ser Thr
  65                  70                  75                  80

 aaa gat gat gaa tta gct tca acc act act cca aag aga ggg aga cct      408
 Lys Asp Asp Glu Leu Ala Ser Thr Thr Thr Pro Lys Arg Gly Arg Pro
                  85                  90                  95

 aaa ggt aac atc tca cgg acg tgt tca cac tgt ggc ctt ttg gcc tct      456
 Lys Gly Asn Ile Ser Arg Thr Cys Ser His Cys Gly Leu Leu Ala Ser
             100                 105                 110

 agt att aca aac ttg act gtt cac att aga cga aaa cac agt cac cag      504
 Ser Ile Thr Asn Leu Thr Val His Ile Arg Arg Lys His Ser His Gln
         115                 120                 125

 tat agt tat tta tgc aaa gtg tgt aag tat tac act gta act aag gga      552
 Tyr Ser Tyr Leu Cys Lys Val Cys Lys Tyr Tyr Thr Val Thr Lys Gly
     130                 135                 140

 gat atg gaa cgt cat tgt gcc acc aag aaa cat aaa gga cgg gta gaa      600
 Asp Met Glu Arg His Cys Ala Thr Lys Lys His Lys Gly Arg Val Glu
 145                 150                 155                 160

 ata gaa gca agt gga aaa cac agt tca gat atc att gtt ggc cct gaa      648
 Ile Glu Ala Ser Gly Lys His Ser Ser Asp Ile Ile Val Gly Pro Glu
                 165                 170                 175

 ggg ggt agc ctt gaa gct ggt aaa aag aat gct ggc tca gca gtg acc      696
 Gly Gly Ser Leu Glu Ala Gly Lys Lys Asn Ala Gly Ser Ala Val Thr
             180                 185                 190

 atg tca gat gaa cat gct aac aaa cca gct gag tca ccc acc tcc gtt      744
 Met Ser Asp Glu His Ala Asn Lys Pro Ala Glu Ser Pro Thr Ser Val
         195                 200                 205

 tta gag aag cca gat cgt gga aac tca att gaa gct gaa gtt gaa aat      792
 Leu Glu Lys Pro Asp Arg Gly Asn Ser Ile Glu Ala Glu Val Glu Asn
     210                 215                 220

 gta ttt cat tct cta gat gga gaa gtt aac agc cat ctt ctt gat gaa      840
 Val Phe His Ser Leu Asp Gly Glu Val Asn Ser His Leu Leu Asp Glu
 225                 230                 235                 240

 aag gag caa ata tct tca gag cca gag gac ttc gcc cag ccg ggg gat      888
 Lys Glu Gln Ile Ser Ser Glu Pro Glu Asp Phe Ala Gln Pro Gly Asp
                 245                 250                 255

 gtg tac tcc cag aga gat gtt aca ggc aca ggt gag aat aag tgt ttg      936
 Val Tyr Ser Gln Arg Asp Val Thr Gly Thr Gly Glu Asn Lys Cys Leu
             260                 265                 270

 cac tgt gag ttt agt gct cac tcc tct gct tct cta gag ctg cat gta      984
 His Cys Glu Phe Ser Ala His Ser Ser Ala Ser Leu Glu Leu His Val
         275                 280                 285

 aaa cgg aaa cat aca aaa gag ttt gag ttt tat tgc atg gca tgc gat     1032
 Lys Arg Lys His Thr Lys Glu Phe Glu Phe Tyr Cys Met Ala Cys Asp
     290                 295                 300

 tac tac gcg gtg act cgt cgc gag atg acc agg cat gca gca aca gag     1080
 Tyr Tyr Ala Val Thr Arg Arg Glu Met Thr Arg His Ala Ala Thr Glu
 305                 310                 315                 320

 aag cac aaa atg aaa agg cag tct tat ctc aac tct gct aat gta gaa     1128
 Lys His Lys Met Lys Arg Gln Ser Tyr Leu Asn Ser Ala Asn Val Glu
                 325                 330                 335

 gct ggt tct gca gac atg tcc aaa aac atc att atg cct gaa gaa gag     1176
 Ala Gly Ser Ala Asp Met Ser Lys Asn Ile Ile Met Pro Glu Glu Glu
             340                 345                 350

 cat caa caa aat tct gag gaa ttt caa ata att tca ggt caa cca tct     1224
 His Gln Gln Asn Ser Glu Glu Phe Gln Ile Ile Ser Gly Gln Pro Ser
         355                 360                 365

 gat act ctt aaa tct aga aat gct gca gat tgc tct att tta aat gag     1272
 Asp Thr Leu Lys Ser Arg Asn Ala Ala Asp Cys Ser Ile Leu Asn Glu
     370                 375                 380

 aat act aat tta gat atg tct aaa gtg ctc tgc gct gct gac tct gta     1320
 Asn Thr Asn Leu Asp Met Ser Lys Val Leu Cys Ala Ala Asp Ser Val
 385                 390                 395                 400

 gaa gtt gag act gaa gaa gaa tct aat ttc aat gaa gac cat tcc ttt     1368
 Glu Val Glu Thr Glu Glu Glu Ser Asn Phe Asn Glu Asp His Ser Phe
                 405                 410                 415

 tgt gag act ttc caa cag gct cct gtc aag gat aaa gtt agg aaa cct     1416
 Cys Glu Thr Phe Gln Gln Ala Pro Val Lys Asp Lys Val Arg Lys Pro
             420                 425                 430

 gag gag atg atg tca ctt act atg tcc tca aac tat ggc tcc cca agc     1464
 Glu Glu Met Met Ser Leu Thr Met Ser Ser Asn Tyr Gly Ser Pro Ser
         435                 440                 445

 aga ttt caa aat gaa aat tca gga agc tct gcc tta aat tgt gag aca     1512
 Arg Phe Gln Asn Glu Asn Ser Gly Ser Ser Ala Leu Asn Cys Glu Thr
     450                 455                 460

 gca aag aaa aac cat gag ata tcg aat gat gca ggt gag ctg cgt gtc     1560
 Ala Lys Lys Asn His Glu Ile Ser Asn Asp Ala Gly Glu Leu Arg Val
 465                 470                 475                 480

 cat tgt gag ggt gaa gga gga aac gca gga gac ggt gga ggt gtt gtc     1608
 His Cys Glu Gly Glu Gly Gly Asn Ala Gly Asp Gly Gly Gly Val Val
                 485                 490                 495

 ccc cac aga cac ctg tgc cct gtg acg ctc gat ggg gag cgc tcg gct     1656
 Pro His Arg His Leu Cys Pro Val Thr Leu Asp Gly Glu Arg Ser Ala
             500                 505                 510

 gaa agc cct gtg ctc gtt gtg aca aga ata acc aga gaa cag gga aat     1704
 Glu Ser Pro Val Leu Val Val Thr Arg Ile Thr Arg Glu Gln Gly Asn
         515                 520                 525

 ctg gag agc ggg ggt cag aac aga gtt gca cgt ggg cat ggt ttg gaa     1752
 Leu Glu Ser Gly Gly Gln Asn Arg Val Ala Arg Gly His Gly Leu Glu
     530                 535                 540

 gac ttg aaa ggt gac caa gaa gat ccc gtt ctg ggg aat aag gaa att     1800
 Asp Leu Lys Gly Asp Gln Glu Asp Pro Val Leu Gly Asn Lys Glu Ile
 545                 550                 555                 560

 ctg atg aat tca caa cat gaa aca gaa ttt att ttg gag gag gat ggc     1848
 Leu Met Asn Ser Gln His Glu Thr Glu Phe Ile Leu Glu Glu Asp Gly
                 565                 570                 575

 cca gct tct gat agc aca gtt gaa agt agt gat gtc tat gaa act ata     1896
 Pro Ala Ser Asp Ser Thr Val Glu Ser Ser Asp Val Tyr Glu Thr Ile
             580                 585                 590

 att agt att gat gat aaa ggg cag gcc atg tac agt tct ggt cga ttt     1944
 Ile Ser Ile Asp Asp Lys Gly Gln Ala Met Tyr Ser Ser Gly Arg Phe
         595                 600                 605

 gac tcc tcc ata ata aga ata aag aac cct gaa gat ggt gag ttg ata     1992
 Asp Ser Ser Ile Ile Arg Ile Lys Asn Pro Glu Asp Gly Glu Leu Ile
     610                 615                 620

 gac cag tct gaa gag ggc ttg ata gca acg gga gtg aga att agt gag     2040
 Asp Gln Ser Glu Glu Gly Leu Ile Ala Thr Gly Val Arg Ile Ser Glu
 625                 630                 635                 640

 ctg ccc ttg aaa gac tgt gct caa ggt gtg aaa aag aag aaa tct gag     2088
 Leu Pro Leu Lys Asp Cys Ala Gln Gly Val Lys Lys Lys Lys Ser Glu
                 645                 650                 655

 ggc agt tcc att ggt gag tct aca cga att cgc tgt gat gat tgt ggc     2136
 Gly Ser Ser Ile Gly Glu Ser Thr Arg Ile Arg Cys Asp Asp Cys Gly
             660                 665                 670

 ttc tta gca gat gga ctg agt gga ctg aat gtt cac ata gcc atg aag     2184
 Phe Leu Ala Asp Gly Leu Ser Gly Leu Asn Val His Ile Ala Met Lys
         675                 680                 685

 cat cct aca aaa gag aag cac ttc cat tgt tta ctc tgt gga aag tcg     2232
 His Pro Thr Lys Glu Lys His Phe His Cys Leu Leu Cys Gly Lys Ser
     690                 695                 700

 ttc tat acc gaa agc aac ctt cac cag cat ctg gct agt gcc ggc cac     2280
 Phe Tyr Thr Glu Ser Asn Leu His Gln His Leu Ala Ser Ala Gly His
 705                 710                 715                 720

 atg aga aat gag cag gcc agt gtg gag gag ctt ccg gag gga ggg gcc     2328
 Met Arg Asn Glu Gln Ala Ser Val Glu Glu Leu Pro Glu Gly Gly Ala
                 725                 730                 735

 acc ttt aaa tgt gtc aag tgc aca gag ccc ttt gat tct gaa cag aat     2376
 Thr Phe Lys Cys Val Lys Cys Thr Glu Pro Phe Asp Ser Glu Gln Asn
             740                 745                 750

 tta ttt cta cat att aaa gga cag cat gag gaa ttg ctg cgg gag gtg     2424
 Leu Phe Leu His Ile Lys Gly Gln His Glu Glu Leu Leu Arg Glu Val
         755                 760                 765

 aat aag tat ata gtg gaa gac act gag caa atc aac cgc gag agg gag     2472
 Asn Lys Tyr Ile Val Glu Asp Thr Glu Gln Ile Asn Arg Glu Arg Glu
     770                 775                 780

 gaa aac cag gga aac gtc tgc aag tat tgt ggg aag atg tgt cga agc     2520
 Glu Asn Gln Gly Asn Val Cys Lys Tyr Cys Gly Lys Met Cys Arg Ser
 785                 790                 795                 800

 agc aac tcg atg gcc ttc ctg gca cac att cgc act cac aca gga tca     2568
 Ser Asn Ser Met Ala Phe Leu Ala His Ile Arg Thr His Thr Gly Ser
                 805                 810                 815

 aaa cca ttc aag tgc aag ata tgc cat ttt gca aca gct cag ctt gga     2616
 Lys Pro Phe Lys Cys Lys Ile Cys His Phe Ala Thr Ala Gln Leu Gly
             820                 825                 830

 gat gcc aga gac cat gtg aaa agg cac ctt ggg atg agg gaa tac aag     2664
 Asp Ala Arg Asp His Val Lys Arg His Leu Gly Met Arg Glu Tyr Lys
         835                 840                 845

 tgc cat gtc tgt ggg gtt gct ttt gta atg aag aag cac tta aat act     2712
 Cys His Val Cys Gly Val Ala Phe Val Met Lys Lys His Leu Asn Thr
     850                 855                 860

 cat cta cta ggc aag cat gga gtt ggc acc cca aaa gaa agg aaa ttt     2760
 His Leu Leu Gly Lys His Gly Val Gly Thr Pro Lys Glu Arg Lys Phe
 865                 870                 875                 880

 aca tgc cac tta tgt gat aga agt ttc aca gag aag tgg gcc ctg aac     2808
 Thr Cys His Leu Cys Asp Arg Ser Phe Thr Glu Lys Trp Ala Leu Asn
                 885                 890                 895

 aac cac atg aaa ctc cac acg gga gaa aag ccg ttt aaa tgt acc tgg     2856
 Asn His Met Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys Thr Trp
             900                 905                 910

 ccc acg tgc cat tac tca ttc ctc aca gcc tcc gca atg aaa gac cac     2904
 Pro Thr Cys His Tyr Ser Phe Leu Thr Ala Ser Ala Met Lys Asp His
         915                 920                 925

 tac agg acg cac aca ggc gag aag tcg ttt ctg tgt gac ctc tgc ggc     2952
 Tyr Arg Thr His Thr Gly Glu Lys Ser Phe Leu Cys Asp Leu Cys Gly
     930                 935                 940

 ttt gcc ggc ggg acc cgc cac gcc ctc acc aag cat cgc aga cag cac     3000
 Phe Ala Gly Gly Thr Arg His Ala Leu Thr Lys His Arg Arg Gln His
 945                 950                 955                 960

 aca gga gaa aaa cct ttc aag tgc gat gag tgt aac ttt gcc tcc aca     3048
 Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Asn Phe Ala Ser Thr
                 965                 970                 975

 act cag tcc cat ttg act cgg cat aaa cgt gtc cac act gga gaa aag     3096
 Thr Gln Ser His Leu Thr Arg His Lys Arg Val His Thr Gly Glu Lys
             980                 985                 990

 ccc tac aga tgc ccc tgg tgt gac tac agg tca aac tgt gct gaa aat     3144
 Pro Tyr Arg Cys Pro Trp Cys Asp Tyr Arg Ser Asn Cys Ala Glu Asn
         995                1000                1005

 atc cgc aaa cac att ctg cat act ggc aaa cat gaa gga gtc aag atg     3192
 Ile Arg Lys His Ile Leu His Thr Gly Lys His Glu Gly Val Lys Met
    1010                1015                1020

 tac aac tgt ccc aag tgt gac tac ggg acc aac gtc ccg gtg gag ttc     3240
 Tyr Asn Cys Pro Lys Cys Asp Tyr Gly Thr Asn Val Pro Val Glu Phe
1025                1030                1035                1040

 cgg aac cat ttg aag gaa cag cat cct gac atc gaa aac ccg gac ctc     3288
 Arg Asn His Leu Lys Glu Gln His Pro Asp Ile Glu Asn Pro Asp Leu
                1045                1050                1055

 gct tac ctg cat gct ggt aag gga cag aaa ctg tga aaac ttgtttctaa     3338
 Ala Tyr Leu His Ala Gly Lys Gly Gln Lys Leu 
            1060                1065

 caggatttca tgtgatcaca gcagttataa tgctatttgt acattaccat gatttattgt   3398

 aatggagtag agtatgtgat agtatctgct tcaagaccta tagaaaagta cattccagtt   3458

 tgatcccact caactatgaa aacaggactt ttcaactgta ttttatcaaa aaaggaaatc   3518

 tgacagagta attatttgat gactgtaaag ttaataatag taaatattta aagcatagtt   3578

 gacctgaaat gagagtagtt gttaaatctt catatgttga ctaattgcta aaattttaa    3637




      <210> 346
      <211> 991
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(833)

      <400> 346
 gtgtgggcat ccagctgttg aataagacct ggaaggag    atg cgg gct aca cag      53
                                              Met Arg Ala Thr Gln
                                                1               5

 gag gac ttc gac aag gtc atg cag gtg gtg cgg gag cag ctg gcc cgc      101
 Glu Asp Phe Asp Lys Val Met Gln Val Val Arg Glu Gln Leu Ala Arg
                  10                  15                  20

 act ctg gcc ctg aag ccc act tcc ctg gag ctc ttc cga acc aag gtg      149
 Thr Leu Ala Leu Lys Pro Thr Ser Leu Glu Leu Phe Arg Thr Lys Val
              25                  30                  35

 aat gcg ctc act tat ggg gag gtg ctg cgg ctg cgg cag act gaa cgg      197
 Asn Ala Leu Thr Tyr Gly Glu Val Leu Arg Leu Arg Gln Thr Glu Arg
          40                  45                  50

 ctg cac cag gag ggc aca ctg gct ccc cct ata ctg gag ctg cgg gag      245
 Leu His Gln Glu Gly Thr Leu Ala Pro Pro Ile Leu Glu Leu Arg Glu
      55                  60                  65

 aag ctg aag cca gag ctc atg ggc ctg atc cgc cag cag cgc ttg ctc      293
 Lys Leu Lys Pro Glu Leu Met Gly Leu Ile Arg Gln Gln Arg Leu Leu
  70                  75                  80                  85

 cgc ctc tgt gag ggg acg ctc ttc cgc aag atc agc agc cgg cgg cgc      341
 Arg Leu Cys Glu Gly Thr Leu Phe Arg Lys Ile Ser Ser Arg Arg Arg
                  90                  95                 100

 cag gat aag ctg tgg ttc tgc tgc ctg tcc ccc aac cac aag ctg ctg      389
 Gln Asp Lys Leu Trp Phe Cys Cys Leu Ser Pro Asn His Lys Leu Leu
             105                 110                 115

 cag tac gga gac atg gag gag ggc gcc agc ccg cct acc ctg gag agt      437
 Gln Tyr Gly Asp Met Glu Glu Gly Ala Ser Pro Pro Thr Leu Glu Ser
         120                 125                 130

 ctg ccc gag caa ctc cct gtg gcc gac atg agg gca ctc ctg aca ggc      485
 Leu Pro Glu Gln Leu Pro Val Ala Asp Met Arg Ala Leu Leu Thr Gly
     135                 140                 145

 aag gac tgc ccc cat gtc cgg gag aag ggc tcc ggg aag cag aac aag      533
 Lys Asp Cys Pro His Val Arg Glu Lys Gly Ser Gly Lys Gln Asn Lys
 150                 155                 160                 165

 gac ctc tat gag ttg gcc ttc tca atc agc tat gac cgt ggg gag gag      581
 Asp Leu Tyr Glu Leu Ala Phe Ser Ile Ser Tyr Asp Arg Gly Glu Glu
                 170                 175                 180

 gaa gcg tac ctc aac ttc att gcc ccc tcc aag cgg gag ttc tac ctg      629
 Glu Ala Tyr Leu Asn Phe Ile Ala Pro Ser Lys Arg Glu Phe Tyr Leu
             185                 190                 195

 tgg aca gat ggg ctc agt gcc ttg ctg ggc agt ccc atg ggc agc gag      677
 Trp Thr Asp Gly Leu Ser Ala Leu Leu Gly Ser Pro Met Gly Ser Glu
         200                 205                 210

 cag aca cgg ctg gac ctg gag cag ctg ctg acc atg gag acc aag ctg      725
 Gln Thr Arg Leu Asp Leu Glu Gln Leu Leu Thr Met Glu Thr Lys Leu
     215                 220                 225

 cgt ctg ctg gag ctg gag aac gtg ccc atc ccc gag cgg cca ccc cct      773
 Arg Leu Leu Glu Leu Glu Asn Val Pro Ile Pro Glu Arg Pro Pro Pro
 230                 235                 240                 245

 gtg ccc cca ccc ccc acc aac ttc aac ttc tgc tat gac tgc agc atc      821
 Val Pro Pro Pro Pro Thr Asn Phe Asn Phe Cys Tyr Asp Cys Ser Ile
                 250                 255                 260

 gct gaa cct tga cag tgtggctggc catgggccac agctgcggcc actgcagcag      876
 Ala Glu Pro 


 ccatgaaggg cagtgggtag aggagtgcag gcaccctgac cagcagagat tgctgcagaa    936

 ataaagtctg cttggctctt gggatatgtt gagccagctc tgtaaaaaaa aaaaa         991




      <210> 347
      <211> 664
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(381)

      <400> 347
 cccacgcgtt cggagaactt acagatctac taagttcttc aatgtgtgcg gaacaaagac     60

 aagaagcaga tagagaagct gaccaagctt ggataccctg aactaatcaa ttatacagaa    120

 cccattaatg ggcttagtgc tttgcactta gcctcagttt ccaatgatat tgat  atg     177
                                                              Met
                                                                1

 gtc agc ttt ctc ctt gac ctt ggt gct cac cct gat gtg caa gac cga      225
 Val Ser Phe Leu Leu Asp Leu Gly Ala His Pro Asp Val Gln Asp Arg
               5                  10                  15

 atg ggc tgt act ccc aca atg agg gct gca gaa ctg ggc cat gaa ttg      273
 Met Gly Cys Thr Pro Thr Met Arg Ala Ala Glu Leu Gly His Glu Leu
          20                  25                  30

 tca atg gaa ata tta gca aag gca aag gct gat atg act ata gtt gat      321
 Ser Met Glu Ile Leu Ala Lys Ala Lys Ala Asp Met Thr Ile Val Asp
      35                  40                  45

 aat gaa gga aaa ggt aaa aat ccc gac atc ctc tcc agc aga ttg caa      369
 Asn Glu Gly Lys Gly Lys Asn Pro Asp Ile Leu Ser Ser Arg Leu Gln
  50                  55                  60                  65

 ttc att ttg tag cca gaaagcaata acatggactc tttttgtttt ccaactttag      424
 Phe Ile Leu 


 aagtgaatta cttatggttt taagggaaag gctaaattct cactcctata cctaaaccta    484

 ctgtctcctc atactttgaa aatgagatag ctatatctta gggaaatcat ttatgagagc    544

 ttgctcatat acttagatta atttgtgttt ggtggtttct tttaaatgag gagaattttg    604

 aacattatac acactgatta ttcattataa attataaact cttctttaaa acaaaaaaaa    664




      <210> 348
      <211> 435
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(338)

      <400> 348
 gggaggctgt gccgccggcc tgagcccaga gtttcgcggc ctccgcg  atg gca gag      56
                                                      Met Ala Glu
                                                        1

 gtg gag gaa acc tta aag agg atc cag agt cat aaa ggg gtt att gga      104
 Val Glu Glu Thr Leu Lys Arg Ile Gln Ser His Lys Gly Val Ile Gly
       5                  10                  15

 act atg gtt gta aat gca gaa ggt att ccc atc cga aca acc ttg gac      152
 Thr Met Val Val Asn Ala Glu Gly Ile Pro Ile Arg Thr Thr Leu Asp
  20                  25                  30                  35

 aac tca aca act gtt caa tat gca ggc ctt ctt cat cac ctg aca atg      200
 Asn Ser Thr Thr Val Gln Tyr Ala Gly Leu Leu His His Leu Thr Met
                  40                  45                  50

 aaa gcc aaa agc aca gtt cgt gat att gat cct cag aac gac ctg act      248
 Lys Ala Lys Ser Thr Val Arg Asp Ile Asp Pro Gln Asn Asp Leu Thr
              55                  60                  65

 ttt ctt agg atc aga tca aag aaa cat gaa atc atg gta gct cca gat      296
 Phe Leu Arg Ile Arg Ser Lys Lys His Glu Ile Met Val Ala Pro Asp
          70                  75                  80

 aag gaa tat ctt ctg atc gtc att cag aat cca tgt gaa tag acctgcg      345
 Lys Glu Tyr Leu Leu Ile Val Ile Gln Asn Pro Cys Glu 
      85                  90                  95

 atggccaagg ctgtttaagc gacactgggt tggaaacact tggctctctc atgagtatta    405

 aaattctatt tcaatcaaaa aaaaaaaaaa                                     435




      <210> 349
      <211> 892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(842)

      <400> 349
 accaagaatc aatactacaa ctgcaggagc tccttcatct taaattcggt gtagccacag     60

 aaatacttct caaacaagct agtactttgg cagatctgga cagtggaaat   atg gaa     116
                                                          Met Glu
                                                            1

 aaa gtc att aaa gat gaa aat gtt act ctg tat gtg tgg gca aac ctc      164
 Lys Val Ile Lys Asp Glu Asn Val Thr Leu Tyr Val Trp Ala Asn Leu
           5                  10                  15

 aag aag aat cca agg cac aga agt gtt aga ttc tct gaa aca caa att      212
 Lys Lys Asn Pro Arg His Arg Ser Val Arg Phe Ser Glu Thr Gln Ile
      20                  25                  30

 gga ttt gag att cca agg ata tta gca aca agt gac att gct gta cga      260
 Gly Phe Glu Ile Pro Arg Ile Leu Ala Thr Ser Asp Ile Ala Val Arg
  35                  40                  45                  50

 ctc ctg cat acc cac tat gat cat gtt tct gca ctg cac cct gtt tca      308
 Leu Leu His Thr His Tyr Asp His Val Ser Ala Leu His Pro Val Ser
                  55                  60                  65

 aca cca tca aaa gaa tac act tct gca gta act gag ctt gtc aaa gat      356
 Thr Pro Ser Lys Glu Tyr Thr Ser Ala Val Thr Glu Leu Val Lys Asp
              70                  75                  80

 gat gtt aag aat gta gaa aaa gca atc agc aag gag gtc gaa gaa gag      404
 Asp Val Lys Asn Val Glu Lys Ala Ile Ser Lys Glu Val Glu Glu Glu
          85                  90                  95

 tcc aaa caa caa gaa aga ggg tct cac tta att cag gag gaa gaa ata      452
 Ser Lys Gln Gln Glu Arg Gly Ser His Leu Ile Gln Glu Glu Glu Ile
     100                 105                 110

 aaa gtt gag gag gaa caa ggt gat att gaa gtg aaa atg agt tct gct      500
 Lys Val Glu Glu Glu Gln Gly Asp Ile Glu Val Lys Met Ser Ser Ala
 115                 120                 125                 130

 gag gaa gaa tct gaa gcc ata aaa tgt gaa cga gag atg aaa gta tta      548
 Glu Glu Glu Ser Glu Ala Ile Lys Cys Glu Arg Glu Met Lys Val Leu
                 135                 140                 145

 agt gaa act gtt tca gca gca cag ttg ttg ctg gta gag aat tct tct      596
 Ser Glu Thr Val Ser Ala Ala Gln Leu Leu Leu Val Glu Asn Ser Ser
             150                 155                 160

 gaa aag cca gat ttc ttt gaa gac aat gtg gtg gat tta tgc cag ttc      644
 Glu Lys Pro Asp Phe Phe Glu Asp Asn Val Val Asp Leu Cys Gln Phe
         165                 170                 175

 aca act ctg ggt gga gta tac cac ttg gat att ttg gag ctt cct cca      692
 Thr Thr Leu Gly Gly Val Tyr His Leu Asp Ile Leu Glu Leu Pro Pro
     180                 185                 190

 cag tgt aaa cca gtg aag gga tgg atg att gtg gaa ata ctc aaa gaa      740
 Gln Cys Lys Pro Val Lys Gly Trp Met Ile Val Glu Ile Leu Lys Glu
 195                 200                 205                 210

 gga tta cag aaa tac aca tat cct ccg gaa act aca gaa gag ttt gag      788
 Gly Leu Gln Lys Tyr Thr Tyr Pro Pro Glu Thr Thr Glu Glu Phe Glu
                 215                 220                 225

 aca gaa aat gct ttc cca cct ata gag gtc cac ttg agg ttc atg aga      836
 Thr Glu Asn Ala Phe Pro Pro Ile Glu Val His Leu Arg Phe Met Arg
             230                 235                 240

 atg taa tcttttttga ggatcctgtg gttgtaaggt gggatgctga aggtaaacat       892
 Met 






      <210> 350
      <211> 2116
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (296)..(2116)

      <400> 350
 taccactcct atagatcagt agacgaagcg gcttagtgta tgccgccagg cttaccaatg     60

 cactttacgg tctcggacac cagagcaggt catggtggac tttgctgctt tgggaccatt    120

 aacatttcaa ctcctacaca tcctgccctt tgactcagta agaaaaagaa tgtctgttgt    180

 ggtccgacac cctctttcca atcaagttgt ggtgtatacg aaaggcgctg attctgtgat    240

 catggagtta ctgtcggtgg cttccccaga ttgagcaagt ctggagaaac aacag atg     298
                                                              Met
                                                                1

 ata gta agg gag aaa acc cag aag cac ttg gat gac tat gcc aaa caa      346
 Ile Val Arg Glu Lys Thr Gln Lys His Leu Asp Asp Tyr Ala Lys Gln
               5                  10                  15

 ggc ctt cgt act tta tgt ata gca aag aag gtc atg agt gac act gaa      394
 Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val Met Ser Asp Thr Glu
          20                  25                  30

 tat gca gag tgg ctg agg aat cat ttt tta gct gaa acc agc att gac      442
 Tyr Ala Glu Trp Leu Arg Asn His Phe Leu Ala Glu Thr Ser Ile Asp
      35                  40                  45

 aac agg gaa gaa tta cta ctt gaa tct gcc atg agg ttg gag aac aaa      490
 Asn Arg Glu Glu Leu Leu Leu Glu Ser Ala Met Arg Leu Glu Asn Lys
  50                  55                  60                  65

 ctt aca tta ctt ggt gct act ggc att gaa gac cgt ctg cag gag gga      538
 Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp Arg Leu Gln Glu Gly
                  70                  75                  80

 gtc cct gaa tct ata gaa gct ctt cac aaa gcg ggc atc aag atc tgg      586
 Val Pro Glu Ser Ile Glu Ala Leu His Lys Ala Gly Ile Lys Ile Trp
              85                  90                  95

 atg ctg aca ggg gac aag cag gag aca gct gtc aac ata gct tat gca      634
 Met Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile Ala Tyr Ala
         100                 105                 110

 tgc aaa cta ctg gag cca gat gac aag ctt ttt atc ctc aat acc caa      682
 Cys Lys Leu Leu Glu Pro Asp Asp Lys Leu Phe Ile Leu Asn Thr Gln
     115                 120                 125

 agt aaa gat gcc tgt ggg atg ctg atg agc aca att ttg aaa gaa ctt      730
 Ser Lys Asp Ala Cys Gly Met Leu Met Ser Thr Ile Leu Lys Glu Leu
 130                 135                 140                 145

 cag aag aaa act caa gcc ctg cca gag caa gtg tca tta agt gaa gat      778
 Gln Lys Lys Thr Gln Ala Leu Pro Glu Gln Val Ser Leu Ser Glu Asp
                 150                 155                 160

 tta ctt cag cct cct gtc ccc cgg gac tca ggg tta cga gct gga ctc      826
 Leu Leu Gln Pro Pro Val Pro Arg Asp Ser Gly Leu Arg Ala Gly Leu
             165                 170                 175

 att atc act ggg aag acc ctg gag ttt gcc ctg caa gaa agt ctg caa      874
 Ile Ile Thr Gly Lys Thr Leu Glu Phe Ala Leu Gln Glu Ser Leu Gln
         180                 185                 190

 aag cag ttc ctg gaa ctg aca tct tgg tgt caa gct gtg gtc tgc tgc      922
 Lys Gln Phe Leu Glu Leu Thr Ser Trp Cys Gln Ala Val Val Cys Cys
     195                 200                 205

 cga gcc aca ccg ctg cag aaa agt gaa gtg gtg aaa ttg gtc cgc agc      970
 Arg Ala Thr Pro Leu Gln Lys Ser Glu Val Val Lys Leu Val Arg Ser
 210                 215                 220                 225

 cat ctc cag gtg atg acc ctt gct att ggt gat ggt gcc aat gat gtt     1018
 His Leu Gln Val Met Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val
                 230                 235                 240

 agc atg ata caa gtg gca gac att ggg ata ggg gtc tca ggt caa gaa     1066
 Ser Met Ile Gln Val Ala Asp Ile Gly Ile Gly Val Ser Gly Gln Glu
             245                 250                 255

 ggc atg cag gct gtg atg gcc agt gac ttt gcc gtt tct cag ttc aaa     1114
 Gly Met Gln Ala Val Met Ala Ser Asp Phe Ala Val Ser Gln Phe Lys
         260                 265                 270

 cat ctc agc aag ctc ctt ctt gtc cat gga cac tgg tgt tat aca cgg     1162
 His Leu Ser Lys Leu Leu Leu Val His Gly His Trp Cys Tyr Thr Arg
     275                 280                 285

 ctt tcc aac atg att ctc tat ttt ttc tat aag aat gtg gcc tat gtg     1210
 Leu Ser Asn Met Ile Leu Tyr Phe Phe Tyr Lys Asn Val Ala Tyr Val
 290                 295                 300                 305

 aac ctc ctt ttc tgg tac cag ttc ttt tgt gga ttt tca gga aca tcc     1258
 Asn Leu Leu Phe Trp Tyr Gln Phe Phe Cys Gly Phe Ser Gly Thr Ser
                 310                 315                 320

 atg act gat tac tgg gtt ttg atc ttc ttc aac ctc ctc ttc aca tct     1306
 Met Thr Asp Tyr Trp Val Leu Ile Phe Phe Asn Leu Leu Phe Thr Ser
             325                 330                 335

 gcc cct cct gtc att tat ggt gtt ttg gag aaa gat gtg tct gca gag     1354
 Ala Pro Pro Val Ile Tyr Gly Val Leu Glu Lys Asp Val Ser Ala Glu
         340                 345                 350

 acc ctc atg caa ctg cct gaa ctt tac aaa agt ggt cag aaa tca gag     1402
 Thr Leu Met Gln Leu Pro Glu Leu Tyr Lys Ser Gly Gln Lys Ser Glu
     355                 360                 365

 gca tac tta ccc cat acc ttc tgg atc acc tta ttg gat gct ttt tat     1450
 Ala Tyr Leu Pro His Thr Phe Trp Ile Thr Leu Leu Asp Ala Phe Tyr
 370                 375                 380                 385

 caa agc ctg gtc tgc ttc ttt gtg cct tat ttt acc tac cag ggc tca     1498
 Gln Ser Leu Val Cys Phe Phe Val Pro Tyr Phe Thr Tyr Gln Gly Ser
                 390                 395                 400

 gat act gac atc ttt gca ttt gga aac ccc ctg aac aca gcc gct ctg     1546
 Asp Thr Asp Ile Phe Ala Phe Gly Asn Pro Leu Asn Thr Ala Ala Leu
             405                 410                 415

 ttc atc gtt ctc ctc cat ctg gtc att gaa agc aag agt ttg act tgg     1594
 Phe Ile Val Leu Leu His Leu Val Ile Glu Ser Lys Ser Leu Thr Trp
         420                 425                 430

 att cac ttg ctg gtc atc att ggt agc atc ttg tct tat ttt tta ttt     1642
 Ile His Leu Leu Val Ile Ile Gly Ser Ile Leu Ser Tyr Phe Leu Phe
     435                 440                 445

 gcc ata gtt ttt gga gcc atg tgt gta act tgc aac cca cca tcc aac     1690
 Ala Ile Val Phe Gly Ala Met Cys Val Thr Cys Asn Pro Pro Ser Asn
 450                 455                 460                 465

 cct tac tgg att atg cag gag cac atg ctg gat cca gta ttc tac tta     1738
 Pro Tyr Trp Ile Met Gln Glu His Met Leu Asp Pro Val Phe Tyr Leu
                 470                 475                 480

 gtt tgt atc ctc acg acg tcc att gct ctt ctg ccc agg ttt gta tac     1786
 Val Cys Ile Leu Thr Thr Ser Ile Ala Leu Leu Pro Arg Phe Val Tyr
             485                 490                 495

 aga gtt ctt cag gga tcc ctg ttt cca tct cca att ctg aga gct aag     1834
 Arg Val Leu Gln Gly Ser Leu Phe Pro Ser Pro Ile Leu Arg Ala Lys
         500                 505                 510

 cac ttt gac aga cta act cca gag gag agg act aaa gct ctc aag aag     1882
 His Phe Asp Arg Leu Thr Pro Glu Glu Arg Thr Lys Ala Leu Lys Lys
     515                 520                 525

 tgg aga ggg gct gga aag atg aat caa gtg aca tca aag tat gct aac     1930
 Trp Arg Gly Ala Gly Lys Met Asn Gln Val Thr Ser Lys Tyr Ala Asn
 530                 535                 540                 545

 caa tca gct ggc aag tca gga aga aga ccc atg cct ggc cct tct gct     1978
 Gln Ser Ala Gly Lys Ser Gly Arg Arg Pro Met Pro Gly Pro Ser Ala
                 550                 555                 560

 gta ttt gca atg aag tca gca act tcc tgt gct att gag caa gga aac     2026
 Val Phe Ala Met Lys Ser Ala Thr Ser Cys Ala Ile Glu Gln Gly Asn
             565                 570                 575

 tta tct ctg tgt gaa act gct tta gat caa ggc tac tct gaa act aag     2074
 Leu Ser Leu Cys Glu Thr Ala Leu Asp Gln Gly Tyr Ser Glu Thr Lys
         580                 585                 590

 gcc ttt gag atg gct gga ccc tcc aaa ggt aaa gaa agc tag             2116
 Ala Phe Glu Met Ala Gly Pro Ser Lys Gly Lys Glu Ser 
     595                 600                 605





      <210> 351
      <211> 770
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (564)..(770)

      <400> 351
 ctgtggtgga attctgtgcc cgtagagcct taggcatgat aatttttgct atcgtttcct     60

 tggtcacact aataacttct gttgtgatgt cctctgtaac tttgcatagt tctgttcaaa    120

 cggctcagta cgtagagaat tggacacgta cagccaacca agcgaggcta cttcagaata    180

 aaattaacac tgagttacaa actgaagtgg caatgttgaa atccatggtt ctgtggttag    240

 gggaacaagt ataaagcttg cagttgcagc ggcaattgcg ctgtcatttt aatcacactc    300

 gtatttgtgt aaccaactta gaatataaca aaagtgagta tccgtgggac cttgtgaaag    360

 cccatttgca aggagctttc acatccaaca tcacctttga tattagtgaa ttacaaaaca    420

 aaattcttga tttaaatagg cacactcaag aatttcagcc ttctttagaa gactggactg    480

 aattccagga aggcctggag agcctcaacc cttggaccta tctaaagtac cacagtaaca    540

 tcttatatgt agttcttgga gta    atg ttg ttt tgt ctc tgt ctt ctg ttt     590
                              Met Leu Phe Cys Leu Cys Leu Leu Phe
                                1               5

 ata gtc tgt aaa atc gga tgg acc gcc aat cgg aga atg aga gct gcc      638
 Ile Val Cys Lys Ile Gly Trp Thr Ala Asn Arg Arg Met Arg Ala Ala
  10                  15                  20                  25

 cag cct ggt ctt aca ttc ttt caa tta att cat aaa cag ggg gat atg      686
 Gln Pro Gly Leu Thr Phe Phe Gln Leu Ile His Lys Gln Gly Asp Met
                  30                  35                  40

 cag gga gcc gaa ggc cca tgg gac gtg acc aac tca gca ttc cac tgg      734
 Gln Gly Ala Glu Gly Pro Trp Asp Val Thr Asn Ser Ala Phe His Trp
              45                  50                  55

 agg cta tat gat caa aca gca aac tgt tta tca tga                      770
 Arg Leu Tyr Asp Gln Thr Ala Asn Cys Leu Ser 
          60                  65





      <210> 352
      <211> 3575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2468)..(3226)

      <400> 352
 gcctagaggg agaaaacttg ttgaaattca gagatccccc tccccctacc agtacacacc     60

 aaatcagacg cctctgacca gatctgaatt tggctctcag agatttccat tgtagccagg    120

 cagttggggc actttctgag tgctgcctcc acctcactgt ccccagcctg cctgcctccg    180

 tttccctagc cctgggcctg tgccgctgtc accatcacct gggcgccctc tagtggatga    240

 atcggattat gcacgagggg gcttggagca ggattcagaa ggggctcctg tccttccttg    300

 aaatgctgga cgccgggatc ctggaacagc tcttcaggtc tctgcattcc tcctggcaac    360

 agccagagcc tgggcgcagg gggctactgt tgtttgaagg ctgaaggctg cagcctggta    420

 gggcactcag gagacctggc agttggctgc agggccaggt ctaggggcca gggcatgagg    480

 gatgctctgg gctggctcag ccccgggccc ccatgcggat tgtgactgtg ggggcatggc    540

 cacatgatgt tgagggggga tctctgaccc tgaccttctt ggctctgtgc atccttgaaa    600

 ccagaaaggt ctggaacaaa tcagtgaaca atgccctaac tcggggaggg agccacatcc    660

 tgaccccagc agcctcagaa ggatccgtgt cagggttatg gggcaccctg ggggccccga    720

 gtctgcatgg gtctccacgt gcaacttctg ccggaaactc tgaaaaatcc caactgcggg    780

 ggtcatagga cacaatcaga aatgctgatg ccactgtgtg tggatccccg ggccctgggg    840

 gtcaggagca tgtagaaggt gggccacagg gggttcataa gagaatcctg taaccgcccc    900

 tgccccccaa acttagaagc ccactggagg gccatgggtg aaagcttggg ggggtgtcct    960

 gtggagtggg tggtgggggg tctttgggtt tacatgctgc tgggcctgag cagcaggacc   1020

 ccgtccacag ctgatccctg ggccctgctg ctcagctgct ctcttgagtg ttgctgtggc   1080

 tgccgagaga gcctgagtcg agcctctctt gtgccggccg tacgctgtca ggccacgctg   1140

 gtgagtttgg caaggcacag atgcccagag cagagaactt tccttgggga tttaatatgt   1200

 gcgaatcttg aggtccggca aatctttccc tcagctagag agggggtttt tgagaccaga   1260

 atcacctcag catcctcctg tccccagctg tgtccagcct gtctgcaggg acatcctgag   1320

 aggactaggc tctcccctca tccacctgcg taagtgccac cctgaagcct gtccacccat   1380

 gcttggagag gcttggcctc aacctgctta gccagcagca ggcttgggcc tggggtgcag   1440

 tagagaccca ggtggctgtg gggtggttgc ttcatggggt ggttctgaaa cgcagttgga   1500

 agtgcatgga cagtgcctta cctgttctct gtgggaccct gtttagaaac caggtctgag   1560

 ttactggggg tcatcgctac attctgatgg cctagctgtg tggaggccac ggtggagccc   1620

 catccaagga gccagggccc tgggtctagc cgtgaccaga acgcatgccc tggaggtgtt   1680

 tctcatcttg cacctgtgtt gcctggtgtc tcaagtggcc acaaaactct gtgttagctc   1740

 taggtgcccc tgggcttcgg aaccagggtt tcccttcatc tcagtgaccc gggagcatct   1800

 gggcagtgag taaagagggt gatttacttg atgggtacgt ttggtcctgc ctaggagccc   1860

 ccccaggcac ggtcctggga cctgaagctg ccctcgttgg tggaggggag ggagagagct   1920

 tcagggatga ggtggcgttg agctgggcgg gaagggtgag cccctgcaag gtggggtggg   1980

 tgtgctgggg acgctgagca gcacggccag caggtgggtc ttcagctcgg tacccggtgg   2040

 gacttgtggt tggggctggt gtgtggccag gagaggggct ggcagaagac aagggggact   2100

 gtgaggcagc tcccatccag cggttgaagc ctgatggcct ggctctgtgc ctcagttctc   2160

 tcatctataa aatgagaaaa cagtgccagc ctcccagacc tgtcatgagg atgaacgagt   2220

 gaccacgtag catgggctgg gtgcgtgtca cctaacatta ccagcctttg caaggagagc   2280

 cctggggacc tggctgagtt tttcccttgc ctggcccact gcacctgtcc ccacaggagc   2340

 caaggaggtc ctgctgctgg cccggtagac ggaccaatgg agggtctcgc tggacacacc   2400

 ggacttcacc gacatcgtgc tgcagctgga cgacatccag catgccatcg ccatcaacta   2460

 tgaccca  atg gag ggc cac gtc tac tgg acg gat gac gag gtg tgg gcc    2509
          Met Glu Gly His Val Tyr Trp Thr Asp Asp Glu Val Trp Ala
            1               5                  10

 atc cgc agg gca tac ctg gat ggg tct ggg gcg cag acg ctg atc aac     2557
 Ile Arg Arg Ala Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Ile Asn
  15                  20                  25                  30

 acc aag atc aac gac ccc gat gac atc gca gtc aac tgg gtg gcc cga     2605
 Thr Lys Ile Asn Asp Pro Asp Asp Ile Ala Val Asn Trp Val Ala Arg
                  35                  40                  45

 agc ctc tat tgg acc cac aca ggc act gaa cac atc gag gtg acg tgc     2653
 Ser Leu Tyr Trp Thr His Thr Gly Thr Glu His Ile Glu Val Thr Cys
              50                  55                  60

 ctc aac agc acc tcc cac aag atc ctg gtg tca gag gac atg gac gag     2701
 Leu Asn Ser Thr Ser His Lys Ile Leu Val Ser Glu Asp Met Asp Glu
          65                  70                  75

 ccc cgt gcc att gca ctg cat ccc gag atg ggc ctc aca tac tgg ata     2749
 Pro Arg Ala Ile Ala Leu His Pro Glu Met Gly Leu Thr Tyr Trp Ile
      80                  85                  90

 gac tgg gga gag aac cct gaa atc aag cgt gcc aac ctg gac agg cag     2797
 Asp Trp Gly Glu Asn Pro Glu Ile Lys Arg Ala Asn Leu Asp Arg Gln
  95                 100                 105                 110

 gag ctg cgc gtg ctg gtc aat gct tcc ctc ggg tgg ccc aac ggc ctg     2845
 Glu Leu Arg Val Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu
                 115                 120                 125

 gcc ctg gac ctg cag gaa ggg aag ctc tac tgg gga gat gcc aag aca     2893
 Ala Leu Asp Leu Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr
             130                 135                 140

 gac aag atc gag gcg atc agt gtc gat gag acg aag agg cag acc ctc     2941
 Asp Lys Ile Glu Ala Ile Ser Val Asp Glu Thr Lys Arg Gln Thr Leu
         145                 150                 155

 ctg aag gac aag ctc cca cac att ttc agg ttc acc ctg ctg ggg gac     2989
 Leu Lys Asp Lys Leu Pro His Ile Phe Arg Phe Thr Leu Leu Gly Asp
     160                 165                 170

 ttc atc tac tgg acc gcc tgg cag cac cac agc atc aag cgg gta cac     3037
 Phe Ile Tyr Trp Thr Ala Trp Gln His His Ser Ile Lys Arg Val His
 175                 180                 185                 190

 aag gtc aag gcc aac cgg gac gtc atc att gac cag ctg ccc gac ctg     3085
 Lys Val Lys Ala Asn Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu
                 195                 200                 205

 atg ggg ctc aaa gct gtg aac gtg gac aag gtc gtc gga acc aac cct     3133
 Met Gly Leu Lys Ala Val Asn Val Asp Lys Val Val Gly Thr Asn Pro
             210                 215                 220

 cat gcg gac agg aat ggg ggt gca gcc acc tgt gct tct tca cgc ccc     3181
 His Ala Asp Arg Asn Gly Gly Ala Ala Thr Cys Ala Ser Ser Arg Pro
         225                 230                 235

 aca caa ccc ggt ttg gct gcc cca tct agg gcc tgg aac tgc tga gtg     3229
 Thr Gln Pro Gly Leu Ala Ala Pro Ser Arg Ala Trp Asn Cys 
     240                 245                 250

 acatgaagac ctgcatcatg cccaaggcct tcttggtctt caccagtaga gccgccatcc   3289

 acaggatctc cctcgagacc aacaacaacg atgtggccat cctgctctcg gcgtcaagga   3349

 ggcctcggcc ctggactttg atgtgtccag caaccacatc tactggacag acatcagcct   3409

 gaaggtagcg tgggcccgaa catgcacacg tgcagcctat atgggaaaac cttccctctg   3469

 tacctgcctc aaaggtttca gacatttttc ttaaagcact ataatattta ttgtaacaca   3529

 attcaagcta attaaatatg agcaagccta tttcaaaaaa aaaaaa                  3575




      <210> 353
      <211> 2262
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(1430)

      <400> 353
 taatacgatc actataggga tttggccctc gaggcaagaa ttcggcacga gggcagtcta     60

 cagctacggg tgatggagta gctagggcct ttcttagagc acaggctgct ttgtttggat    120

 cctacagaga tgcactgaga tacaaacctg gtgagcccat cactttctgt gaggagagtt    180

 ttgtaaagca ccgctcaagc gtg    atg aaa cag ttc ctg gaa act gcc att     230
                              Met Lys Gln Phe Leu Glu Thr Ala Ile
                                1               5

 aac ctc cag ctt ttt aag cag ttt atc gat ggt cga ctg gca aaa cta      278
 Asn Leu Gln Leu Phe Lys Gln Phe Ile Asp Gly Arg Leu Ala Lys Leu
  10                  15                  20                  25

 aat gca gga agg ggt ttc tct gat gta ttt gaa gaa gag atc act tca      326
 Asn Ala Gly Arg Gly Phe Ser Asp Val Phe Glu Glu Glu Ile Thr Ser
                  30                  35                  40

 ggt ggc ttt tgt gga ggg aac ccg agg tca tat caa caa tgg gtg cat      374
 Gly Gly Phe Cys Gly Gly Asn Pro Arg Ser Tyr Gln Gln Trp Val His
              45                  50                  55

 aca gtc aag aaa gga ggt gca ctg ttc aac aca gca atg acc aaa gca      422
 Thr Val Lys Lys Gly Gly Ala Leu Phe Asn Thr Ala Met Thr Lys Ala
          60                  65                  70

 acc cct gct gta cgg aca gca tat aaa ttt gca aaa aat cat gca aag      470
 Thr Pro Ala Val Arg Thr Ala Tyr Lys Phe Ala Lys Asn His Ala Lys
      75                  80                  85

 ctg gga cta aag gaa gtg aag agt aaa cta aaa cac aag gaa aat gaa      518
 Leu Gly Leu Lys Glu Val Lys Ser Lys Leu Lys His Lys Glu Asn Glu
  90                  95                 100                 105

 gaa gat tat ggg acc tgt tct agt tct gta caa tat aca cca gtt tac      566
 Glu Asp Tyr Gly Thr Cys Ser Ser Ser Val Gln Tyr Thr Pro Val Tyr
                 110                 115                 120

 aaa tta cac aat gaa aag gga gga aac tca gaa aag cgt aag ctt gct      614
 Lys Leu His Asn Glu Lys Gly Gly Asn Ser Glu Lys Arg Lys Leu Ala
             125                 130                 135

 cag gca cgc tta aaa agg cct ctt aag agc ctt gat ggt gct cta tat      662
 Gln Ala Arg Leu Lys Arg Pro Leu Lys Ser Leu Asp Gly Ala Leu Tyr
         140                 145                 150

 gat gat gaa gat gat gat gac att gaa aga gca agc aag tta tct tct      710
 Asp Asp Glu Asp Asp Asp Asp Ile Glu Arg Ala Ser Lys Leu Ser Ser
     155                 160                 165

 gaa gat ggt gaa gaa gct tct gct tat ctc tat gag agt gat gac tct      758
 Glu Asp Gly Glu Glu Ala Ser Ala Tyr Leu Tyr Glu Ser Asp Asp Ser
 170                 175                 180                 185

 gtt gaa aca aga gtg aag act cct tac tca ggt gaa atg gac tta cta      806
 Val Glu Thr Arg Val Lys Thr Pro Tyr Ser Gly Glu Met Asp Leu Leu
                 190                 195                 200

 gga gag att ctt gat aca ttg agc aca cac agc tca gat cag ggg aag      854
 Gly Glu Ile Leu Asp Thr Leu Ser Thr His Ser Ser Asp Gln Gly Lys
             205                 210                 215

 ctg gca gct gca aag agc ttg gat ttc ttt aga tca atg gat gac att      902
 Leu Ala Ala Ala Lys Ser Leu Asp Phe Phe Arg Ser Met Asp Asp Ile
         220                 225                 230

 gat tac aaa cct acg aat aaa tct aat gct cct agt gag aat aac ctg      950
 Asp Tyr Lys Pro Thr Asn Lys Ser Asn Ala Pro Ser Glu Asn Asn Leu
     235                 240                 245

 gct ttc ctc tgt ggt ggt tct ggt gac caa gca gag tgg aat ctt ggg      998
 Ala Phe Leu Cys Gly Gly Ser Gly Asp Gln Ala Glu Trp Asn Leu Gly
 250                 255                 260                 265

 caa gac gat agt gcc ctc cat ggc aaa cac ctc cct cca tct cct agg     1046
 Gln Asp Asp Ser Ala Leu His Gly Lys His Leu Pro Pro Ser Pro Arg
                 270                 275                 280

 aag cgg gtt tcc tct agt ggt ttg aca gat tct ctg ttt atc ctg aaa     1094
 Lys Arg Val Ser Ser Ser Gly Leu Thr Asp Ser Leu Phe Ile Leu Lys
             285                 290                 295

 gag gaa aac agt aac aag cac ctc ggt gct gac aat gtg agt gac cct     1142
 Glu Glu Asn Ser Asn Lys His Leu Gly Ala Asp Asn Val Ser Asp Pro
         300                 305                 310

 act tca gga ctg gat ttc caa ctc act tcc cct gaa gtt tcc cag act     1190
 Thr Ser Gly Leu Asp Phe Gln Leu Thr Ser Pro Glu Val Ser Gln Thr
     315                 320                 325

 gat aaa gga aaa aca gaa aag agg gaa aca cta agc cag att tca gat     1238
 Asp Lys Gly Lys Thr Glu Lys Arg Glu Thr Leu Ser Gln Ile Ser Asp
 330                 335                 340                 345

 gat ctg ctt ata ccc ggt ctt ggg cgg cat tca tcg act ttt gtt cct     1286
 Asp Leu Leu Ile Pro Gly Leu Gly Arg His Ser Ser Thr Phe Val Pro
                 350                 355                 360

 tgg gag aaa gaa ggg aaa gaa gcc aaa gag act tca gaa gat att gga     1334
 Trp Glu Lys Glu Gly Lys Glu Ala Lys Glu Thr Ser Glu Asp Ile Gly
             365                 370                 375

 ctg ctc cat gaa gta gtg tca tta tgt cat atg aca tct gac ttc caa     1382
 Leu Leu His Glu Val Val Ser Leu Cys His Met Thr Ser Asp Phe Gln
         380                 385                 390

 caa agc ttg aac att tca gac aaa aac aca aat gga aac caa act taa     1430
 Gln Ser Leu Asn Ile Ser Asp Lys Asn Thr Asn Gly Asn Gln Thr 
     395                 400                 405

 atcttgcatc caagcttcta tggagacatt ttgagattca atgcaatctg tataataaac   1490

 agaattattt gtaggaatgg caactcatac tatttaaatt tttttttgca tttgcaacat   1550

 ttttctcact tgttcatttc gaggatatat gaaatgcatt gatttttaaa tataaagcga   1610

 attctactgt gcttttaaat caggtactag tttgtatgta tgtttaaagt atgtattgac   1670

 catgagattt cccagtgttt ggtgcttaat gccgtttatt ttatttaagc taagaatgca   1730

 tatgtaaccc atgcacataa ccagtagcta ctatactaat ctggttgagc atgaactgat   1790

 caagatatca aaacttatca aaactagcct gaagctgatg aaactgttaa cccactaatt   1850

 gccttaatct taaagctgtt ttttaagcat acttaaataa tgtatgaaag tatgtataaa   1910

 gtttgaagga taagttatta gtgttctgca gagcaataat gcctttttct attcatcaaa   1970

 tcaaggtcaa aattcatctt ttcaagatta aaaagctctc ttaatggaaa tatttaattt   2030

 gcttatataa agcactatag ccatgttttc caaaaagtat aaaaatatac acttaccttt   2090

 cattcagtga aatataggaa gtgctgaatt acaatgtgaa gttaatgact tctgtttaca   2150

 aatgagacac tctaacgagt tttcagtctc tctgtatgcc tttgctattt aggggtccac   2210

 cccaagaaag ccaaatacaa cataaaccgt cctgacaaaa aaaaaaaaaa aa           2262




      <210> 354
      <211> 1048
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(801)

      <400> 354
  atg tcc tcg gtg ttt gga aaa ccc cgc gcg ggc agc ggg cct cag agc      48
  Met Ser Ser Val Phe Gly Lys Pro Arg Ala Gly Ser Gly Pro Gln Ser
    1               5                  10                  15

 gcg ccc ctc gag gtc aac ctg gcc atc ctg ggg cgc cgc ggg gct ggc       96
 Ala Pro Leu Glu Val Asn Leu Ala Ile Leu Gly Arg Arg Gly Ala Gly
              20                  25                  30

 aag tct gcc ctg acc gtg aag ttt ctg acc aag agg ttt atc agt gaa      144
 Lys Ser Ala Leu Thr Val Lys Phe Leu Thr Lys Arg Phe Ile Ser Glu
          35                  40                  45

 tat gac ccc aac ttg gag gac acc tac agc tcc gag gag act gtg gac      192
 Tyr Asp Pro Asn Leu Glu Asp Thr Tyr Ser Ser Glu Glu Thr Val Asp
      50                  55                  60

 cac cag cct gtc cac ctg agg gtc atg gac act gca gac ctg gac acc      240
 His Gln Pro Val His Leu Arg Val Met Asp Thr Ala Asp Leu Asp Thr
  65                  70                  75                  80

 ccc agg aac tgc gag cgc tac ctg aac tgg gcc cat gcc ttc ctg gtg      288
 Pro Arg Asn Cys Glu Arg Tyr Leu Asn Trp Ala His Ala Phe Leu Val
                  85                  90                  95

 gtg tac agc gtc gac agc cgc cag agc ttt gat agc agc agc agc tac      336
 Val Tyr Ser Val Asp Ser Arg Gln Ser Phe Asp Ser Ser Ser Ser Tyr
             100                 105                 110

 ctg gag ctg ctt gcc ttg cac gcg aag gag aca cag cgc agc atc cct      384
 Leu Glu Leu Leu Ala Leu His Ala Lys Glu Thr Gln Arg Ser Ile Pro
         115                 120                 125

 gcc ctg ctg ctg ggc aac aag ctg gac atg gct cag tac agg caa gtc      432
 Ala Leu Leu Leu Gly Asn Lys Leu Asp Met Ala Gln Tyr Arg Gln Val
     130                 135                 140

 acc aag gca gag ggt gtg gct ttg gca ggc agg ttt ggg tgc ctg ttt      480
 Thr Lys Ala Glu Gly Val Ala Leu Ala Gly Arg Phe Gly Cys Leu Phe
 145                 150                 155                 160

 ttc gag gtc tct gcc tgt ctg gac ttt gag cac gtg cag cat gtc ttc      528
 Phe Glu Val Ser Ala Cys Leu Asp Phe Glu His Val Gln His Val Phe
                 165                 170                 175

 cac gag gca gtg cga gag gca cgg cgg gag ctg gag aag agc ccc ctg      576
 His Glu Ala Val Arg Glu Ala Arg Arg Glu Leu Glu Lys Ser Pro Leu
             180                 185                 190

 acc cgg ccc ctc ttc atc tcc gag gag agg gcc ctg ccc cac cag gcc      624
 Thr Arg Pro Leu Phe Ile Ser Glu Glu Arg Ala Leu Pro His Gln Ala
         195                 200                 205

 ccg ctc acc gcg cgg cat ggg ctg gcc agc tgc acc ttc aac acg ctc      672
 Pro Leu Thr Ala Arg His Gly Leu Ala Ser Cys Thr Phe Asn Thr Leu
     210                 215                 220

 tcc acc atc aac ctg aag gag atg ccc act gtg gcc cag gcc aag ctg      720
 Ser Thr Ile Asn Leu Lys Glu Met Pro Thr Val Ala Gln Ala Lys Leu
 225                 230                 235                 240

 gtc acc gtg aag tca tcc cgg gcc cag agc aag cgc aag gcg cct acc      768
 Val Thr Val Lys Ser Ser Arg Ala Gln Ser Lys Arg Lys Ala Pro Thr
                 245                 250                 255

 ctg act ctc ctg aag ggc ttc aag atc ttc tga ggccccct ccccaggaag      819
 Leu Thr Leu Leu Lys Gly Phe Lys Ile Phe 
             260                 265

 cctaggctcg gtggctggac aggactgcag caggacaggg actggcttct caccaccagc    879

 ctttccgtct gatggacagc agaccccgcc tccagcacca agcagtgtcc ctacactcaa    939

 ttcactgtgt gagctggagt ggcaggcagg gatgctgctt ctgttccctc caggccttgg    999

 tcttcatggt aaccaccgcg tctgtggccg tagagggaaa cagccactg               1048




      <210> 355
      <211> 3687
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(3372)

      <400> 355
 tccggaattc ccgggtcgac gatttcgtat tggcgacttg cttccttttg cagaacggcc     60

 gctcctctct cggtccagct gcgacgctgg gaaagcgcca gacttggtct gtcacgggag    120

 cccccgcggg gcgtggcgag ggagagctgg cctaggctgc gagggactct cgtttcttgc    180

 ctggagagcc aggaagaggg cgagggcaga gcatccttgg gcggagatgc ctttaaaaaa    240

 tcatccaccg cagcggtaga aacagttttg tttggcttta tttatacgga atggtttttc    300

 agtgaa   atg ctg tct tgc tta aaa gaa gag atg cct ccc cag gag ctc     348
          Met Leu Ser Cys Leu Lys Glu Glu Met Pro Pro Gln Glu Leu
            1               5                  10

 acc cgg cga ctg gcc aca gtg atc act cat gtc gat gaa att atg cag      396
 Thr Arg Arg Leu Ala Thr Val Ile Thr His Val Asp Glu Ile Met Gln
  15                  20                  25                  30

 cag gaa gtc aga ccc ctg atg gcg gtg gag ata ata gaa caa ctt cac      444
 Gln Glu Val Arg Pro Leu Met Ala Val Glu Ile Ile Glu Gln Leu His
                  35                  40                  45

 aga caa ttt gcc att ctt tca gga ggc cga ggg gag gat ggc gcc ccc      492
 Arg Gln Phe Ala Ile Leu Ser Gly Gly Arg Gly Glu Asp Gly Ala Pro
              50                  55                  60

 atc atc acg ttc cca gag ttt tcg ggg ttc aaa cac atc cca gat gaa      540
 Ile Ile Thr Phe Pro Glu Phe Ser Gly Phe Lys His Ile Pro Asp Glu
          65                  70                  75

 gac ttc ctg aat gtc atg acc tac ctg act agc atc ccc agt gtg gag      588
 Asp Phe Leu Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Val Glu
      80                  85                  90

 gct gcc agc att gga ctc att gtt gtt atc gac aga cga aga gac aag      636
 Ala Ala Ser Ile Gly Leu Ile Val Val Ile Asp Arg Arg Arg Asp Lys
  95                 100                 105                 110

 tgg agc tcc gta aag gca tcc ttg aca cga ata gct gtg gca ttt cca      684
 Trp Ser Ser Val Lys Ala Ser Leu Thr Arg Ile Ala Val Ala Phe Pro
                 115                 120                 125

 gga aac tta cag ctc ata ttc atc ctt cgt cca tct cgc ttt atc cag      732
 Gly Asn Leu Gln Leu Ile Phe Ile Leu Arg Pro Ser Arg Phe Ile Gln
             130                 135                 140

 agg aca ttc act gac att ggc att aaa tac tat cga aat gag ttt aaa      780
 Arg Thr Phe Thr Asp Ile Gly Ile Lys Tyr Tyr Arg Asn Glu Phe Lys
         145                 150                 155

 acg aaa gtg ccg atc atc atg gta aac tct gtc tct gac ctt cac ggc      828
 Thr Lys Val Pro Ile Ile Met Val Asn Ser Val Ser Asp Leu His Gly
     160                 165                 170

 tac atc gac aaa agc caa ctg acc cgg gaa tta ggg ggg act ttg gaa      876
 Tyr Ile Asp Lys Ser Gln Leu Thr Arg Glu Leu Gly Gly Thr Leu Glu
 175                 180                 185                 190

 tat cgc cac ggt cag tgg gta aat cac cgc act gcc atc gaa aac ttt      924
 Tyr Arg His Gly Gln Trp Val Asn His Arg Thr Ala Ile Glu Asn Phe
                 195                 200                 205

 gcc ttg acc ttg aag acc act gcc cag atg ctg cag acg ttt ggg tcc      972
 Ala Leu Thr Leu Lys Thr Thr Ala Gln Met Leu Gln Thr Phe Gly Ser
             210                 215                 220

 tgc ctg gcc aca gca gag ctg ccc aga agc atg cta tcc acg gaa gac     1020
 Cys Leu Ala Thr Ala Glu Leu Pro Arg Ser Met Leu Ser Thr Glu Asp
         225                 230                 235

 ctt ctc atg tcc cac aca agg cag cgg gac aag ctg cag gat gag ctg     1068
 Leu Leu Met Ser His Thr Arg Gln Arg Asp Lys Leu Gln Asp Glu Leu
     240                 245                 250

 aaa tta ctt gga aag cag ggg acc aca ttg ctg tca tgc atc caa gaa     1116
 Lys Leu Leu Gly Lys Gln Gly Thr Thr Leu Leu Ser Cys Ile Gln Glu
 255                 260                 265                 270

 cca gca acc aaa tgt ccc aac agc aaa ctc aat ctc aac caa ctt gag     1164
 Pro Ala Thr Lys Cys Pro Asn Ser Lys Leu Asn Leu Asn Gln Leu Glu
                 275                 280                 285

 aat gta act acc atg gaa agg tta tta gtt caa ctg gat gaa aca gaa     1212
 Asn Val Thr Thr Met Glu Arg Leu Leu Val Gln Leu Asp Glu Thr Glu
             290                 295                 300

 aaa gcc ttt agt cac ttt tgg tct gag cat cat ctg aag ctt aac cag     1260
 Lys Ala Phe Ser His Phe Trp Ser Glu His His Leu Lys Leu Asn Gln
         305                 310                 315

 tgc cta caa cta cag cat ttt gag cac gat ttt tgt aag gct aag ctt     1308
 Cys Leu Gln Leu Gln His Phe Glu His Asp Phe Cys Lys Ala Lys Leu
     320                 325                 330

 gcc ctg gat aat ttg ctg gaa gag caa gca gag ttt aca ggc att gga     1356
 Ala Leu Asp Asn Leu Leu Glu Glu Gln Ala Glu Phe Thr Gly Ile Gly
 335                 340                 345                 350

 gac agc gtg atg cac gtg gag cag att ctt aag gaa cac aaa aaa ctg     1404
 Asp Ser Val Met His Val Glu Gln Ile Leu Lys Glu His Lys Lys Leu
                 355                 360                 365

 gag gaa aaa agc cag gag ccc ctg gaa aag gcc cag ctg ctg gca ctg     1452
 Glu Glu Lys Ser Gln Glu Pro Leu Glu Lys Ala Gln Leu Leu Ala Leu
             370                 375                 380

 gtt ggg gac cag ctc atc caa agc cac cat tat gca gca gat gcc atc     1500
 Val Gly Asp Gln Leu Ile Gln Ser His His Tyr Ala Ala Asp Ala Ile
         385                 390                 395

 agg ccc cgg tgt gtg gag ctc agg cac ctc tgt gac gat ttc atc aat     1548
 Arg Pro Arg Cys Val Glu Leu Arg His Leu Cys Asp Asp Phe Ile Asn
     400                 405                 410

 gga aac aag aaa aaa tgg gac att tta gga aag tcc tta gag ttt cat     1596
 Gly Asn Lys Lys Lys Trp Asp Ile Leu Gly Lys Ser Leu Glu Phe His
 415                 420                 425                 430

 aga cag ctg gac aag gtc agc caa tgg tgt gag gca gga atc tac ctc     1644
 Arg Gln Leu Asp Lys Val Ser Gln Trp Cys Glu Ala Gly Ile Tyr Leu
                 435                 440                 445

 ttg gct tcg caa gct gta gac aag tgc cag tct cga gaa ggg gtt gat     1692
 Leu Ala Ser Gln Ala Val Asp Lys Cys Gln Ser Arg Glu Gly Val Asp
             450                 455                 460

 atc gcc ttg aac gac att gcg aca ttc ctg ggc aca gtc aag gag tac     1740
 Ile Ala Leu Asn Asp Ile Ala Thr Phe Leu Gly Thr Val Lys Glu Tyr
         465                 470                 475

 ccg ttg ctc agc ccc aag gag ttt tac aac gag ttt gag ttg ctg ctc     1788
 Pro Leu Leu Ser Pro Lys Glu Phe Tyr Asn Glu Phe Glu Leu Leu Leu
     480                 485                 490

 acc ctc gat gca aag gcc aaa gcc cag aaa gtt ttg cag agg ctg gat     1836
 Thr Leu Asp Ala Lys Ala Lys Ala Gln Lys Val Leu Gln Arg Leu Asp
 495                 500                 505                 510

 gat gtc cag gaa ata ttt cac aag agg caa gtg agt ctg atg aaa ctg     1884
 Asp Val Gln Glu Ile Phe His Lys Arg Gln Val Ser Leu Met Lys Leu
                 515                 520                 525

 gca gcc aaa cag act cgt cca gtg caa cct gtg gcc cca cat cct gag     1932
 Ala Ala Lys Gln Thr Arg Pro Val Gln Pro Val Ala Pro His Pro Glu
             530                 535                 540

 tct tca cca aaa tgg gtg tca tca aaa acc agc cag ccc tcc acc tcg     1980
 Ser Ser Pro Lys Trp Val Ser Ser Lys Thr Ser Gln Pro Ser Thr Ser
         545                 550                 555

 gtc cct cta gct cgt cct ctg aga acg tct gag gaa cct tat acg gag     2028
 Val Pro Leu Ala Arg Pro Leu Arg Thr Ser Glu Glu Pro Tyr Thr Glu
     560                 565                 570

 aca gag ttg aac tcc cgg gga aag gaa gat gat gag act aaa ttt gaa     2076
 Thr Glu Leu Asn Ser Arg Gly Lys Glu Asp Asp Glu Thr Lys Phe Glu
 575                 580                 585                 590

 gtc aag agt gaa gaa atc ttt gaa agc cat cat gaa agg ggg aac cct     2124
 Val Lys Ser Glu Glu Ile Phe Glu Ser His His Glu Arg Gly Asn Pro
                 595                 600                 605

 gag ctg gag cag cag gcc agg ctc gga gac ctt tcc ccc cgc agg cgc     2172
 Glu Leu Glu Gln Gln Ala Arg Leu Gly Asp Leu Ser Pro Arg Arg Arg
             610                 615                 620

 att ata cgt gac ttg ctt gag act gaa gag att tac ata aaa gag att     2220
 Ile Ile Arg Asp Leu Leu Glu Thr Glu Glu Ile Tyr Ile Lys Glu Ile
         625                 630                 635

 aaa agc ata att gat gga tat atc act cca atg gat ttt att tgg cta     2268
 Lys Ser Ile Ile Asp Gly Tyr Ile Thr Pro Met Asp Phe Ile Trp Leu
     640                 645                 650

 aag cat cta att cca gat gtt ctt cag aat aac aag gac ttt ctc ttt     2316
 Lys His Leu Ile Pro Asp Val Leu Gln Asn Asn Lys Asp Phe Leu Phe
 655                 660                 665                 670

 ggg aat att aga gaa ctt tac gaa ttt cac aac agg act ttt cta aaa     2364
 Gly Asn Ile Arg Glu Leu Tyr Glu Phe His Asn Arg Thr Phe Leu Lys
                 675                 680                 685

 gag ttg gaa aag tgt gct gag aac cct gaa ctt ctg gca cat tgc ttt     2412
 Glu Leu Glu Lys Cys Ala Glu Asn Pro Glu Leu Leu Ala His Cys Phe
             690                 695                 700

 ctc aag aga aaa gaa gat ctt cag ata tat ttt aaa tac cat aag aat     2460
 Leu Lys Arg Lys Glu Asp Leu Gln Ile Tyr Phe Lys Tyr His Lys Asn
         705                 710                 715

 ctg ccc cga gct agg gca atc tgg caa gag tgt caa gac tgc gcc tac     2508
 Leu Pro Arg Ala Arg Ala Ile Trp Gln Glu Cys Gln Asp Cys Ala Tyr
     720                 725                 730

 ttt ggg gta tgc cag cgc caa ctg gat cac aat ctc cct ctt ttt aag     2556
 Phe Gly Val Cys Gln Arg Gln Leu Asp His Asn Leu Pro Leu Phe Lys
 735                 740                 745                 750

 tat ctc aaa gga cca agc cag aga ctt ata aaa tac cag atg ctg ttg     2604
 Tyr Leu Lys Gly Pro Ser Gln Arg Leu Ile Lys Tyr Gln Met Leu Leu
                 755                 760                 765

 aag ggt ctg ctg gat ttc gag tct cct gaa gat atg gag ata gac cca     2652
 Lys Gly Leu Leu Asp Phe Glu Ser Pro Glu Asp Met Glu Ile Asp Pro
             770                 775                 780

 ggt gaa cta gga ggc tcg gct aag gat ggg cca aag aga acc aaa gat     2700
 Gly Glu Leu Gly Gly Ser Ala Lys Asp Gly Pro Lys Arg Thr Lys Asp
         785                 790                 795

 tca gca ttc tca act gaa cta caa caa gct ttg gca gtg ata gag gat     2748
 Ser Ala Phe Ser Thr Glu Leu Gln Gln Ala Leu Ala Val Ile Glu Asp
     800                 805                 810

 ttg atc aag tcc tgt gag ttg gct gtg gac cta gca gca gtg act gaa     2796
 Leu Ile Lys Ser Cys Glu Leu Ala Val Asp Leu Ala Ala Val Thr Glu
 815                 820                 825                 830

 tgt ccg gac gat att gga aaa cta ggc aag ctg ttg ctg cac ggc cct     2844
 Cys Pro Asp Asp Ile Gly Lys Leu Gly Lys Leu Leu Leu His Gly Pro
                 835                 840                 845

 ttc agc gtc tgg aca att cac aag gat cgt tat aaa atg aag gat ttg     2892
 Phe Ser Val Trp Thr Ile His Lys Asp Arg Tyr Lys Met Lys Asp Leu
             850                 855                 860

 att cga ttt aaa ccc agc cag agg caa atc tac cta ttt gaa agg gga     2940
 Ile Arg Phe Lys Pro Ser Gln Arg Gln Ile Tyr Leu Phe Glu Arg Gly
         865                 870                 875

 ata gtg ttc tgt aag ata cga atg gag cct ggg gac cag gga tta tct     2988
 Ile Val Phe Cys Lys Ile Arg Met Glu Pro Gly Asp Gln Gly Leu Ser
     880                 885                 890

 cct cat tac agc ttc aag aag gcc atg aag ctg atg aca ctt tca att     3036
 Pro His Tyr Ser Phe Lys Lys Ala Met Lys Leu Met Thr Leu Ser Ile
 895                 900                 905                 910

 cgc cag ctt gga agg ggg agc cat aga aag ttt gag att gcc agt cga     3084
 Arg Gln Leu Gly Arg Gly Ser His Arg Lys Phe Glu Ile Ala Ser Arg
                 915                 920                 925

 aat gga ctt gag aaa tac atc ctg cag gca gct tca aaa gaa atc aga     3132
 Asn Gly Leu Glu Lys Tyr Ile Leu Gln Ala Ala Ser Lys Glu Ile Arg
             930                 935                 940

 gac tgt tgg ttt tca gaa ata agt aaa tta ttg atg gaa caa caa aat     3180
 Asp Cys Trp Phe Ser Glu Ile Ser Lys Leu Leu Met Glu Gln Gln Asn
         945                 950                 955

 aat atc aaa gac caa gga aat cca cag ttt gaa atg agc acg agc aaa     3228
 Asn Ile Lys Asp Gln Gly Asn Pro Gln Phe Glu Met Ser Thr Ser Lys
     960                 965                 970

 ggc agt gga gca gga tcc ggg gga cca tgg att aaa aat atg gaa aga     3276
 Gly Ser Gly Ala Gly Ser Gly Gly Pro Trp Ile Lys Asn Met Glu Arg
 975                 980                 985                 990

 gct acc act agc aag gaa gac ccg gcc tcc agc aca gga ggg att aaa     3324
 Ala Thr Thr Ser Lys Glu Asp Pro Ala Ser Ser Thr Gly Gly Ile Lys
                 995                1000                1005

 ggt agg gag ggt ccc atg gga gag tgg agc aca gaa gca gtg ggg tga     3372
 Gly Arg Glu Gly Pro Met Gly Glu Trp Ser Thr Glu Ala Val Gly 
            1010                1015                1020

 tgccagctgc ttagatgcta aggaagacat cacctagggc ccagcccttc tttagttaaa   3432

 tgagggagaa aaaagaaagc attttaccac catgtggttt aaaatcaatt tcctgctatt   3492

 catttgtgta gaactaatgg ggcagaatta acatgaaggg caaatgtctc acattgagaa   3552

 gtacaggagc acccccttat ccactgtttc actttccagg ttttagttac tcttagtcaa   3612

 ctgctgtcca aatatcaaat ggaaaaatta cagaaataaa caatcgatga gttttaaatg   3672

 aaaaaaaaaa aaaaa                                                    3687




      <210> 356
      <211> 5647
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(5647)

      <400> 356
 aggctgcaga atctccggga gtcgagctcg tgcgccggcg cactggcgcg ctccgtttac     60

 acgctccggg gcctgtatgc gccgcgagtt ccggctgtcg ccgtcgccgc ggcggctcct    120

 ggaggtcggt tgcgacgagt aacggcgcca ggacgagccc tgcgccttct ttttcgat      178                                                                 
 atg tac ccg aat tgg ggc cgg tat ggc ggg agc agc cac tat ccg ccg      226
 Met Tyr Pro Asn Trp Gly Arg Tyr Gly Gly Ser Ser His Tyr Pro Pro
   1               5                  10                  15

 cca ccg gtc cca ccg ccg ccg cca gtg gcg ctt cct gag gcc tcg ccg      274
 Pro Pro Val Pro Pro Pro Pro Pro Val Ala Leu Pro Glu Ala Ser Pro
              20                  25                  30

 ggg ccc gga tac tcg agc tcg acg act ccc gcg gcc ccc tcc tcc tcg      322
 Gly Pro Gly Tyr Ser Ser Ser Thr Thr Pro Ala Ala Pro Ser Ser Ser
          35                  40                  45

 ggc ttc atg agc ttc cgc gaa cag cac ttg gcg cag ctc cag cag ctg      370
 Gly Phe Met Ser Phe Arg Glu Gln His Leu Ala Gln Leu Gln Gln Leu
      50                  55                  60

 cag cag atg cac cag aag caa atg cag tgc gtg ctt cag ccc cac cac      418
 Gln Gln Met His Gln Lys Gln Met Gln Cys Val Leu Gln Pro His His
  65                  70                  75                  80

 ctt cct ccg ccc cct ctg ccg ccc ccg cca gtg atg ccg ggg ggc ggc      466
 Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Val Met Pro Gly Gly Gly
                  85                  90                  95

 tac gga gac tgg cag ccg cca ccg cca ccg atg ccc ccg cca ccc ggg      514
 Tyr Gly Asp Trp Gln Pro Pro Pro Pro Pro Met Pro Pro Pro Pro Gly
             100                 105                 110

 ccg gcc ctc agc tat cag aag cag cag cag tac aaa cac cag atg ctc      562
 Pro Ala Leu Ser Tyr Gln Lys Gln Gln Gln Tyr Lys His Gln Met Leu
         115                 120                 125

 cac cac caa cga gac ggg cct cct ggt ttg gtt cca atg gag ctg gaa      610
 His His Gln Arg Asp Gly Pro Pro Gly Leu Val Pro Met Glu Leu Glu
     130                 135                 140

 tcc ccc cct gaa tct ccc cct gtg ccg cct ggg tcc tat atg ccc cca      658
 Ser Pro Pro Glu Ser Pro Pro Val Pro Pro Gly Ser Tyr Met Pro Pro
 145                 150                 155                 160

 tct cag tct tac atg ccc cca cct cag ccg cca ccc tct tac tac ccc      706
 Ser Gln Ser Tyr Met Pro Pro Pro Gln Pro Pro Pro Ser Tyr Tyr Pro
                 165                 170                 175

 ccg acc tca tct cag ccc tac ctg cct cct gct cag ccg tcc cct tcg      754
 Pro Thr Ser Ser Gln Pro Tyr Leu Pro Pro Ala Gln Pro Ser Pro Ser
             180                 185                 190

 cag tcc cca cct tcc caa tcc tac ctg gcg ccc acc cct tct tac tca      802
 Gln Ser Pro Pro Ser Gln Ser Tyr Leu Ala Pro Thr Pro Ser Tyr Ser
         195                 200                 205

 tcc tcc tcc tct tcc tcg caa tcc tat ttg agc cat tcc cag tcc tac      850
 Ser Ser Ser Ser Ser Ser Gln Ser Tyr Leu Ser His Ser Gln Ser Tyr
     210                 215                 220

 ttg ccc tct tct cag gca tct cct tcc cgc ccc tcc cag ggc cat tct      898
 Leu Pro Ser Ser Gln Ala Ser Pro Ser Arg Pro Ser Gln Gly His Ser
 225                 230                 235                 240

 aaa tcc caa cta cta gct cca cca cca ccg tcc gcc ccc cct gga aat      946
 Lys Ser Gln Leu Leu Ala Pro Pro Pro Pro Ser Ala Pro Pro Gly Asn
                 245                 250                 255

 aag aca act gtc cag caa gag cct ttg gag agt ggg gcc aaa aac aag      994
 Lys Thr Thr Val Gln Gln Glu Pro Leu Glu Ser Gly Ala Lys Asn Lys
             260                 265                 270

 agt act gaa cag cag caa gcc gcc cct gag cca gat ccc tct acg atg     1042
 Ser Thr Glu Gln Gln Gln Ala Ala Pro Glu Pro Asp Pro Ser Thr Met
         275                 280                 285

 act cca cag gaa cag cag cag tat tgg tat cga cag cac ttg ctt agt     1090
 Thr Pro Gln Glu Gln Gln Gln Tyr Trp Tyr Arg Gln His Leu Leu Ser
     290                 295                 300

 ttg caa cag agg aca aaa gtt cat ttg cca gga cac aaa aag ggt cct     1138
 Leu Gln Gln Arg Thr Lys Val His Leu Pro Gly His Lys Lys Gly Pro
 305                 310                 315                 320

 gtg gta gca aag gat aca cca gag ccg gta aaa gaa gaa gtt aca gta     1186
 Val Val Ala Lys Asp Thr Pro Glu Pro Val Lys Glu Glu Val Thr Val
                 325                 330                 335

 cct gcc acc agt caa gtt cca gaa tct cct tct tct gag gag ccc cca     1234
 Pro Ala Thr Ser Gln Val Pro Glu Ser Pro Ser Ser Glu Glu Pro Pro
             340                 345                 350

 ttg cca cct cca aat gag gaa gtg cca cct cct ctc cca cct gag gaa     1282
 Leu Pro Pro Pro Asn Glu Glu Val Pro Pro Pro Leu Pro Pro Glu Glu
         355                 360                 365

 ccc cag tct gag gac cca gaa gaa gat gcc agg tta aag cag ttg cag     1330
 Pro Gln Ser Glu Asp Pro Glu Glu Asp Ala Arg Leu Lys Gln Leu Gln
     370                 375                 380

 gct gca gca gca cac tgg cag cag cac cag cag cat cga gtc ggt ttc     1378
 Ala Ala Ala Ala His Trp Gln Gln His Gln Gln His Arg Val Gly Phe
 385                 390                 395                 400

 cag tat cag gga ata atg cag aag cac act cag tta cag cag att cta     1426
 Gln Tyr Gln Gly Ile Met Gln Lys His Thr Gln Leu Gln Gln Ile Leu
                 405                 410                 415

 caa cag tat cag cag att ata cag ccc cca cca cat ata cag gca act     1474
 Gln Gln Tyr Gln Gln Ile Ile Gln Pro Pro Pro His Ile Gln Ala Thr
             420                 425                 430

 aca cct cct cca gga ata cct ccc cct gga gtt cca caa ggg ata cct     1522
 Thr Pro Pro Pro Gly Ile Pro Pro Pro Gly Val Pro Gln Gly Ile Pro
         435                 440                 445

 cct cag tta aca gca gcc cca gtt cca cca gcc tcc agt tca cag agc     1570
 Pro Gln Leu Thr Ala Ala Pro Val Pro Pro Ala Ser Ser Ser Gln Ser
     450                 455                 460

 tcg caa gtt cca gag aaa cct aga cca gca ctg ctt cct act cct gtg     1618
 Ser Gln Val Pro Glu Lys Pro Arg Pro Ala Leu Leu Pro Thr Pro Val
 465                 470                 475                 480

 tct ttt ggt tct gcc cca ccg aca act tac cat cct ccg ttg caa tca     1666
 Ser Phe Gly Ser Ala Pro Pro Thr Thr Tyr His Pro Pro Leu Gln Ser
                 485                 490                 495

 gct ggt cca tca gaa caa gtg aat tca aaa gct cct ttg agc aag tct     1714
 Ala Gly Pro Ser Glu Gln Val Asn Ser Lys Ala Pro Leu Ser Lys Ser
             500                 505                 510

 gct ctg cca tac agt tca ttc tca tct gat caa gga ctt ggg gag tct     1762
 Ala Leu Pro Tyr Ser Ser Phe Ser Ser Asp Gln Gly Leu Gly Glu Ser
         515                 520                 525

 tca gct gct cca tct cag cca atc act gca gtg aag gac atg cca gtg     1810
 Ser Ala Ala Pro Ser Gln Pro Ile Thr Ala Val Lys Asp Met Pro Val
     530                 535                 540

 aga tca ggt ggc ctg ctt cca gat cct cct aga agt agt tac ttg gaa     1858
 Arg Ser Gly Gly Leu Leu Pro Asp Pro Pro Arg Ser Ser Tyr Leu Glu
 545                 550                 555                 560

 agt cca aga ggc cca aga ttt gat ggt cct cga aga ttt gag gat tta     1906
 Ser Pro Arg Gly Pro Arg Phe Asp Gly Pro Arg Arg Phe Glu Asp Leu
                 565                 570                 575

 ggg tca agg tgt gaa gga ccg aga ccc aaa ggg cct cgt ttt gaa gga     1954
 Gly Ser Arg Cys Glu Gly Pro Arg Pro Lys Gly Pro Arg Phe Glu Gly
             580                 585                 590

 aat cgc ccc gat ggg cca aga ccc aga tat gaa ggt cac cca gca gag     2002
 Asn Arg Pro Asp Gly Pro Arg Pro Arg Tyr Glu Gly His Pro Ala Glu
         595                 600                 605

 ggc act aaa agc aag tgg gga atg att ccc cgg ggg cca gca tct caa     2050
 Gly Thr Lys Ser Lys Trp Gly Met Ile Pro Arg Gly Pro Ala Ser Gln
     610                 615                 620

 ttt tat att acc ccc agt aca tcc cta agt cct cga cag agt gga cca     2098
 Phe Tyr Ile Thr Pro Ser Thr Ser Leu Ser Pro Arg Gln Ser Gly Pro
 625                 630                 635                 640

 cag tgg aaa ggc ccc aaa cca gct ttt gga cag cag cat cag cag caa     2146
 Gln Trp Lys Gly Pro Lys Pro Ala Phe Gly Gln Gln His Gln Gln Gln
                 645                 650                 655

 cct aag tca caa gca gaa cct ctt tca gga aac aaa gaa cca tta gca     2194
 Pro Lys Ser Gln Ala Glu Pro Leu Ser Gly Asn Lys Glu Pro Leu Ala
             660                 665                 670

 gac acc agt agt aac cag cag aag aat ttt aaa atg caa tca gct gca     2242
 Asp Thr Ser Ser Asn Gln Gln Lys Asn Phe Lys Met Gln Ser Ala Ala
         675                 680                 685

 ttt tcc att gct gca gat gta aag gat gtc aag gcg gct cag tca aat     2290
 Phe Ser Ile Ala Ala Asp Val Lys Asp Val Lys Ala Ala Gln Ser Asn
     690                 695                 700

 gag aat cta agc gac tct caa caa gag cca cct aaa agt gaa gtc tcg     2338
 Glu Asn Leu Ser Asp Ser Gln Gln Glu Pro Pro Lys Ser Glu Val Ser
 705                 710                 715                 720

 gaa ggg ccc gta gag ccc tct aat tgg gac cag aat gtt caa agt atg     2386
 Glu Gly Pro Val Glu Pro Ser Asn Trp Asp Gln Asn Val Gln Ser Met
                 725                 730                 735

 gag act caa atc gac aaa gcc caa gct gtt act cag cct gta ccc ctt     2434
 Glu Thr Gln Ile Asp Lys Ala Gln Ala Val Thr Gln Pro Val Pro Leu
             740                 745                 750

 gcg aat aag cct gta cct gct caa tct act ttt cct tca aaa aca ggg     2482
 Ala Asn Lys Pro Val Pro Ala Gln Ser Thr Phe Pro Ser Lys Thr Gly
         755                 760                 765

 ggg atg gag gga gga aca gca gta gca aca tca tca tta aca gca gat     2530
 Gly Met Glu Gly Gly Thr Ala Val Ala Thr Ser Ser Leu Thr Ala Asp
     770                 775                 780

 aat gat ttt aaa cct gtg ggt att ggt cta ccc cat tca gaa aac aac     2578
 Asn Asp Phe Lys Pro Val Gly Ile Gly Leu Pro His Ser Glu Asn Asn
 785                 790                 795                 800

 caa gat aaa ggc ctg cct cgg cca gat aat aga gat aat aga tta gaa     2626
 Gln Asp Lys Gly Leu Pro Arg Pro Asp Asn Arg Asp Asn Arg Leu Glu
                 805                 810                 815

 ggc aat aga ggc aac agc tca tct tac aga ggt cct ggg caa agc aga     2674
 Gly Asn Arg Gly Asn Ser Ser Ser Tyr Arg Gly Pro Gly Gln Ser Arg
             820                 825                 830

 atg gaa gac aca cgg gat aaa ggt cta gta aac aga ggt cgc ggc cag     2722
 Met Glu Asp Thr Arg Asp Lys Gly Leu Val Asn Arg Gly Arg Gly Gln
         835                 840                 845

 gca atc agt cga ggc cca gga ttg gtc aag caa gaa gac ttt cgg gat     2770
 Ala Ile Ser Arg Gly Pro Gly Leu Val Lys Gln Glu Asp Phe Arg Asp
     850                 855                 860

 aag atg atg ggt aga aga gaa gat agt cga gag aag atg aac aga gga     2818
 Lys Met Met Gly Arg Arg Glu Asp Ser Arg Glu Lys Met Asn Arg Gly
 865                 870                 875                 880

 gaa ggt agc cgg gac aga ggg ttg gtg agg cct gga agc agt cgg gag     2866
 Glu Gly Ser Arg Asp Arg Gly Leu Val Arg Pro Gly Ser Ser Arg Glu
                 885                 890                 895

 aaa gtg cca ggt ggt ctt caa ggg agc cag gac agg ggt gca gct ggc     2914
 Lys Val Pro Gly Gly Leu Gln Gly Ser Gln Asp Arg Gly Ala Ala Gly
             900                 905                 910

 agc cga gaa agg gga cca cct cgg agg gct ggc agt cag gag agg gga     2962
 Ser Arg Glu Arg Gly Pro Pro Arg Arg Ala Gly Ser Gln Glu Arg Gly
         915                 920                 925

 cct ctt cga agg gct ggg agt aga gag aga ata cca ccc cga aga gct     3010
 Pro Leu Arg Arg Ala Gly Ser Arg Glu Arg Ile Pro Pro Arg Arg Ala
     930                 935                 940

 ggg agc agg gag aga gga cca cct cga ggg cct ggc agt cga gaa agg     3058
 Gly Ser Arg Glu Arg Gly Pro Pro Arg Gly Pro Gly Ser Arg Glu Arg
 945                 950                 955                 960

 gga ctg gga aga tca gat ttt ggt cgt gat aga ggt cca ttc aga cca     3106
 Gly Leu Gly Arg Ser Asp Phe Gly Arg Asp Arg Gly Pro Phe Arg Pro
                 965                 970                 975

 gaa cca gga gat ggt ggg gaa aaa atg tat cca tat cac cgg gat gag     3154
 Glu Pro Gly Asp Gly Gly Glu Lys Met Tyr Pro Tyr His Arg Asp Glu
             980                 985                 990

 cct cct agg gct cca tgg aac cat gga gaa gag cga ggg cat gaa gag     3202
 Pro Pro Arg Ala Pro Trp Asn His Gly Glu Glu Arg Gly His Glu Glu
         995                1000                1005

 ttt cca tta gat ggt aga aat gct cca atg gaa cga gaa aga ctc gat     3250
 Phe Pro Leu Asp Gly Arg Asn Ala Pro Met Glu Arg Glu Arg Leu Asp
    1010                1015                1020

 gac tgg gat aga gag aga tac tgg aga gaa tgt gaa cgt gac tat caa     3298
 Asp Trp Asp Arg Glu Arg Tyr Trp Arg Glu Cys Glu Arg Asp Tyr Gln
1025                1030                1035                1040

 gat gat aca cta gag ctc tat aac aga gag gac agg ttc tca gca cca     3346
 Asp Asp Thr Leu Glu Leu Tyr Asn Arg Glu Asp Arg Phe Ser Ala Pro
                1045                1050                1055

 cca tct cgg tct cat gat gga gat agg cga ggc cct tgg tgg gat gat     3394
 Pro Ser Arg Ser His Asp Gly Asp Arg Arg Gly Pro Trp Trp Asp Asp
            1060                1065                1070

 tgg gag aga gac cag gat atg gat gag gac tac aat agg gaa atg gaa     3442
 Trp Glu Arg Asp Gln Asp Met Asp Glu Asp Tyr Asn Arg Glu Met Glu
        1075                1080                1085

 agg gac atg gac agg gat gtg gat cgg att tca aga cct atg gat atg     3490
 Arg Asp Met Asp Arg Asp Val Asp Arg Ile Ser Arg Pro Met Asp Met
    1090                1095                1100

 tat gat aga agt ttg gat aat gag tgg gac aga gat tat ggg aga cca     3538
 Tyr Asp Arg Ser Leu Asp Asn Glu Trp Asp Arg Asp Tyr Gly Arg Pro
1105                1110                1115                1120

 ctg gat gaa caa gaa tca cag ttt cgt gaa cgg gat att cca tct ctt     3586
 Leu Asp Glu Gln Glu Ser Gln Phe Arg Glu Arg Asp Ile Pro Ser Leu
                1125                1130                1135

 cca cct tta ccg ccc ctc cca cct ctt cca cct ttg gat aga tat cgg     3634
 Pro Pro Leu Pro Pro Leu Pro Pro Leu Pro Pro Leu Asp Arg Tyr Arg
            1140                1145                1150

 gat gat aga tgg aga gaa gaa aga aat cga gag cat ggg tat gat cga     3682
 Asp Asp Arg Trp Arg Glu Glu Arg Asn Arg Glu His Gly Tyr Asp Arg
        1155                1160                1165

 gat ttc cgt gat agg ggt gag ttg agg att cga gag tat cca gaa aga     3730
 Asp Phe Arg Asp Arg Gly Glu Leu Arg Ile Arg Glu Tyr Pro Glu Arg
    1170                1175                1180

 gga gat aca tgg cgg gaa aag cga gat tat gtt cct gac aga atg gac     3778
 Gly Asp Thr Trp Arg Glu Lys Arg Asp Tyr Val Pro Asp Arg Met Asp
1185                1190                1195                1200

 tgg gaa aga gaa cgg ttg tca gac aga tgg tac cca tct gat gtg gat     3826
 Trp Glu Arg Glu Arg Leu Ser Asp Arg Trp Tyr Pro Ser Asp Val Asp
                1205                1210                1215

 aga cat tcc ccc atg gcg gaa cat atg ccc tcc tca cat cat tcc tca     3874
 Arg His Ser Pro Met Ala Glu His Met Pro Ser Ser His His Ser Ser
            1220                1225                1230

 gaa atg atg ggg tcc gat gca agc tta gac tct gac caa ggc ctt gga     3922
 Glu Met Met Gly Ser Asp Ala Ser Leu Asp Ser Asp Gln Gly Leu Gly
        1235                1240                1245

 ggg gta atg gtt ctc agt cag agg cag cat gaa atc att ttg aaa gct     3970
 Gly Val Met Val Leu Ser Gln Arg Gln His Glu Ile Ile Leu Lys Ala
    1250                1255                1260

 gca caa gaa ctg aaa atg ctt cgg gaa cag aaa gaa cag ctt caa aag     4018
 Ala Gln Glu Leu Lys Met Leu Arg Glu Gln Lys Glu Gln Leu Gln Lys
1265                1270                1275                1280

 atg aaa gac ttc ggg tct gag cca cag atg gct gac cat cta cca cct     4066
 Met Lys Asp Phe Gly Ser Glu Pro Gln Met Ala Asp His Leu Pro Pro
                1285                1290                1295

 cag gaa tca aga ttg cag aat aca tct tca aga cct gga atg tat ccg     4114
 Gln Glu Ser Arg Leu Gln Asn Thr Ser Ser Arg Pro Gly Met Tyr Pro
            1300                1305                1310

 cct cca ggg tcg tat aga cct ccc cct cct atg ggc aaa cca cca ggt     4162
 Pro Pro Gly Ser Tyr Arg Pro Pro Pro Pro Met Gly Lys Pro Pro Gly
        1315                1320                1325

 tca att gta aga ccc tct gct cca cca gca aga tca tct gtt cct gtg     4210
 Ser Ile Val Arg Pro Ser Ala Pro Pro Ala Arg Ser Ser Val Pro Val
    1330                1335                1340

 acc agg cca cct gtc cca ata cca cca cct cca cct cct cca cct cta     4258
 Thr Arg Pro Pro Val Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu
1345                1350                1355                1360

 cct cct cct cct cca gtg ata aag cca caa act tca gct gta gaa cag     4306
 Pro Pro Pro Pro Pro Val Ile Lys Pro Gln Thr Ser Ala Val Glu Gln
                1365                1370                1375

 gaa cga tgg gat gaa gat tct ttc tat ggg ctc tgg gat aca aat gat     4354
 Glu Arg Trp Asp Glu Asp Ser Phe Tyr Gly Leu Trp Asp Thr Asn Asp
            1380                1385                1390

 gaa caa gga ctg aat tca gaa ttt aag tca gaa act gca gca att cca     4402
 Glu Gln Gly Leu Asn Ser Glu Phe Lys Ser Glu Thr Ala Ala Ile Pro
        1395                1400                1405

 tct gct cca gta tta cca ccc cca cct gtt cac tct tcc att ccc cct     4450
 Ser Ala Pro Val Leu Pro Pro Pro Pro Val His Ser Ser Ile Pro Pro
    1410                1415                1420

 cct ggc cca gtg cct atg ggt atg cca cca atg tcc aag cca cca cca     4498
 Pro Gly Pro Val Pro Met Gly Met Pro Pro Met Ser Lys Pro Pro Pro
1425                1430                1435                1440

 gta caa cag act gtt gat tat ggc cat ggc cga gat ata tcc act aat     4546
 Val Gln Gln Thr Val Asp Tyr Gly His Gly Arg Asp Ile Ser Thr Asn
                1445                1450                1455

 aaa gtt gaa cag ata cct tat gga gaa aga ata act cta cgc cca gat     4594
 Lys Val Glu Gln Ile Pro Tyr Gly Glu Arg Ile Thr Leu Arg Pro Asp
            1460                1465                1470

 cca cta cct gaa aga tca act ttt gag aca gag cat gca ggc caa cgt     4642
 Pro Leu Pro Glu Arg Ser Thr Phe Glu Thr Glu His Ala Gly Gln Arg
        1475                1480                1485

 gat cgt tat gat aga gaa aga gat cgt gag cct tat ttt gat cgt caa     4690
 Asp Arg Tyr Asp Arg Glu Arg Asp Arg Glu Pro Tyr Phe Asp Arg Gln
    1490                1495                1500

 agt aat gtc ata gca gat cat cga gat ttt aaa agg gat cgt gag aca     4738
 Ser Asn Val Ile Ala Asp His Arg Asp Phe Lys Arg Asp Arg Glu Thr
1505                1510                1515                1520

 cat aga gat cga gac cgg gat cgt ggt gtt att gac tat gac cgg gat     4786
 His Arg Asp Arg Asp Arg Asp Arg Gly Val Ile Asp Tyr Asp Arg Asp
                1525                1530                1535

 cga ttt gac aga gaa cgc cga ccc cga gat gat aga gct cag tca tat     4834
 Arg Phe Asp Arg Glu Arg Arg Pro Arg Asp Asp Arg Ala Gln Ser Tyr
            1540                1545                1550

 cga gac aaa aaa gac cat tcc tca tcc aga aga ggg ggt ttt gat agg     4882
 Arg Asp Lys Lys Asp His Ser Ser Ser Arg Arg Gly Gly Phe Asp Arg
        1555                1560                1565

 cca tcc tat gac cgg aag tct gac cga cca gtc tat gaa gga cca tcc     4930
 Pro Ser Tyr Asp Arg Lys Ser Asp Arg Pro Val Tyr Glu Gly Pro Ser
    1570                1575                1580

 atg ttt gga gga gaa cga agg act tat cct gag gag cga atg cct ctg     4978
 Met Phe Gly Gly Glu Arg Arg Thr Tyr Pro Glu Glu Arg Met Pro Leu
1585                1590                1595                1600

 cca gct cct tca ctg agc cac cag cct cct cca gct cca cga gtc gag     5026
 Pro Ala Pro Ser Leu Ser His Gln Pro Pro Pro Ala Pro Arg Val Glu
                1605                1610                1615

 aag aag cct gaa tca aag aat gtg gac gat att ttg aaa cca ccg ggc     5074
 Lys Lys Pro Glu Ser Lys Asn Val Asp Asp Ile Leu Lys Pro Pro Gly
            1620                1625                1630

 cgg gag agc aga cct gag aga att gtt gtt ata atg aga gga tta cct     5122
 Arg Glu Ser Arg Pro Glu Arg Ile Val Val Ile Met Arg Gly Leu Pro
        1635                1640                1645

 ggc agt gga aag aca cat gtt gca aaa ctt att cga gta atg gaa tat     5170
 Gly Ser Gly Lys Thr His Val Ala Lys Leu Ile Arg Val Met Glu Tyr
    1650                1655                1660

 gaa tat gaa gct gag atg gag gag act tac cgc acc agc atg ttc aaa     5218
 Glu Tyr Glu Ala Glu Met Glu Glu Thr Tyr Arg Thr Ser Met Phe Lys
1665                1670                1675                1680

 act ttc aaa aag act ctg gat gat ggc ttt ttt ccc ttc atc atc ctg     5266
 Thr Phe Lys Lys Thr Leu Asp Asp Gly Phe Phe Pro Phe Ile Ile Leu
                1685                1690                1695

 gat gcc atc aat gac aga gtt agg cat ttt gac cag ttt tgg agt gca     5314
 Asp Ala Ile Asn Asp Arg Val Arg His Phe Asp Gln Phe Trp Ser Ala
            1700                1705                1710

 gca aaa acc aag gga ttt gag gta tat ttg gct gaa atg agt gca gat     5362
 Ala Lys Thr Lys Gly Phe Glu Val Tyr Leu Ala Glu Met Ser Ala Asp
        1715                1720                1725

 aac cag act tgt ggc aag aga aat att cat gga aga aag ctt aaa gaa     5410
 Asn Gln Thr Cys Gly Lys Arg Asn Ile His Gly Arg Lys Leu Lys Glu
    1730                1735                1740

 ata aat aag atg gct gat cac tgg gaa act gca cct cgt cac atg atg     5458
 Ile Asn Lys Met Ala Asp His Trp Glu Thr Ala Pro Arg His Met Met
1745                1750                1755                1760

 cgt cta gat att cgt tct ttg ctg caa gat gct gct att gaa gag gta     5506
 Arg Leu Asp Ile Arg Ser Leu Leu Gln Asp Ala Ala Ile Glu Glu Val
                1765                1770                1775

 gag atg gaa gat ttt gat gca aat atc gaa gaa cag aaa gaa gaa aag     5554
 Glu Met Glu Asp Phe Asp Ala Asn Ile Glu Glu Gln Lys Glu Glu Lys
            1780                1785                1790

 aaa gat gca gag gaa gag gaa agc gaa ctg gta gga gac aga cca acc     5602
 Lys Asp Ala Glu Glu Glu Glu Ser Glu Leu Val Gly Asp Arg Pro Thr
        1795                1800                1805

 act ttg aac agt gtc tct tta tta aaa ttc tta aag aag gtt taa         5647
 Thr Leu Asn Ser Val Ser Leu Leu Lys Phe Leu Lys Lys Val 
    1810                1815                1820





      <210> 357
      <211> 577
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(431)

      <400> 357
 gacgccgtcc gcaattcccg ggtcgaccca cgcgtccgcg gacgcgtggg ccacacgtct     60

 gcctccatca ctgccatcgc gatcctgcag ct  atg tcc tac cct gtg acc agt     113
                                      Met Ser Tyr Pro Val Thr Ser
                                        1               5

 cag ccc cag tgc gcc acc acc agc tgc tac cag acc cag ctc agt gac      161
 Gln Pro Gln Cys Ala Thr Thr Ser Cys Tyr Gln Thr Gln Leu Ser Asp
          10                  15                  20

 tgg cac aca ggt ctc acg gac tgc tgc aac gac atg cct gtc tgt ctg      209
 Trp His Thr Gly Leu Thr Asp Cys Cys Asn Asp Met Pro Val Cys Leu
      25                  30                  35

 tgc ggc act ttt gct cct ctg tgc ctt gcc tgc cgc atc tcc gac gac      257
 Cys Gly Thr Phe Ala Pro Leu Cys Leu Ala Cys Arg Ile Ser Asp Asp
  40                  45                  50                  55

 ttt ggc gag tgc tgc tgc gcg ccc tac ctg ccc gga ggc ctg cac tcc      305
 Phe Gly Glu Cys Cys Cys Ala Pro Tyr Leu Pro Gly Gly Leu His Ser
                  60                  65                  70

 atc cgc acc ggc atg cgg gag cgc tac cac atc cag ggc tcc gtc ggg      353
 Ile Arg Thr Gly Met Arg Glu Arg Tyr His Ile Gln Gly Ser Val Gly
              75                  80                  85

 cac gac tgg gcg gcc ctc acc ttt tgt ctg ccc tgc gcc ctc tgc cag      401
 His Asp Trp Ala Ala Leu Thr Phe Cys Leu Pro Cys Ala Leu Cys Gln
          90                  95                 100

 atg gcg cgg gaa ctg aag atc cga gag taa g gaagttccct gtcttccccg      452
 Met Ala Arg Glu Leu Lys Ile Arg Glu 
     105                 110

 tccttttcca ccagtctcgc ctctggcctt ctctggccac tcctgggagg gactgcctca    512

 ccacccctgt cccgctgcca gaaatacacc cacaataaaa acctgaaaac caaaaaaaaa    572

 aaaaa                                                                577




      <210> 358
      <211> 1060
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(761)

      <400> 358
 ggtgagtcgc cctcaggaac agagggcacc tacttggatt ccagtgcaag ctacatcatg     60

 tacatggatg agtcatttgc taaccctcag tttgtccatc tgtaaaacag gagtaaagat    120

 tcccttccta acagggttag agtggggaca aggtcccgcc tgactccgct ctggaaagtc    180

 cttttgaaga a atg gcc ctg gtg agg ggc ggc tgg ctg tgg aga cag agc     230
              Met Ala Leu Val Arg Gly Gly Trp Leu Trp Arg Gln Ser
                1               5                  10

 tcc atc ctc cgc cgc tgg aag cgg aac tgg ttt gcc ctg tgg ctg gac      278
 Ser Ile Leu Arg Arg Trp Lys Arg Asn Trp Phe Ala Leu Trp Leu Asp
      15                  20                  25

 ggg acc ctg gga tac tac cac gat gag aca gcg cag gac gag gag gac      326
 Gly Thr Leu Gly Tyr Tyr His Asp Glu Thr Ala Gln Asp Glu Glu Asp
  30                  35                  40                  45

 cgt gtg ctc atc cac ttc aat gtc cgt gac ata aag atc ggc cca gag      374
 Arg Val Leu Ile His Phe Asn Val Arg Asp Ile Lys Ile Gly Pro Glu
                  50                  55                  60

 tgc cat gat gtg cag ccc cca gag ggc cgg agc cga gat ggc ctg ctg      422
 Cys His Asp Val Gln Pro Pro Glu Gly Arg Ser Arg Asp Gly Leu Leu
              65                  70                  75

 act gtg aac cta cgg gaa ggc ggc cgc ctg cac ctc tgt gcg gag acc      470
 Thr Val Asn Leu Arg Glu Gly Gly Arg Leu His Leu Cys Ala Glu Thr
          80                  85                  90

 aag gat gat gcc cta gca tgg aag aca gca ctg ctg gag gca aac tcc      518
 Lys Asp Asp Ala Leu Ala Trp Lys Thr Ala Leu Leu Glu Ala Asn Ser
      95                 100                 105

 acc ccg gtg cgc gtc tac agc ccg tac caa gac tac tac gag gtg gtg      566
 Thr Pro Val Arg Val Tyr Ser Pro Tyr Gln Asp Tyr Tyr Glu Val Val
 110                 115                 120                 125

 ccc ccc aat gca cac gag gcc acg tat gtc cgc agc tac tac gga ccg      614
 Pro Pro Asn Ala His Glu Ala Thr Tyr Val Arg Ser Tyr Tyr Gly Pro
                 130                 135                 140

 ccc tac gca ggc cct ggc gtg acg cac gtg ata gtg cgg gag gat ccc      662
 Pro Tyr Ala Gly Pro Gly Val Thr His Val Ile Val Arg Glu Asp Pro
             145                 150                 155

 tgc tac agc gcc ggc gcc cct ctg gcc atg ggc atg ctt gcg gga gcc      710
 Cys Tyr Ser Ala Gly Ala Pro Leu Ala Met Gly Met Leu Ala Gly Ala
         160                 165                 170

 gcc act ggg gcg gcg ctg ggc tcg ctc atg tgg tcg ccc tgc tgg ttc      758
 Ala Thr Gly Ala Ala Leu Gly Ser Leu Met Trp Ser Pro Cys Trp Phe
     175                 180                 185

 tga gccc tgggactcgg agcactgacc cctgcgcttg gattgctaga ctcctcttcc      815
 


 tcctggaccc catcctctac catccaagcc ctgtcccact ttggccctat cctctccatt    875

 agctccttcc gggtttggac cattcccccc actccctacc cttaatcccc acatgggaag    935

 aagctatcat cacaggtaca aacatcgctt gaagtcttca catctaccac tagacacccc    995

 caaaatctgt tatagacatt tatggataca tttcctctaa acacaacagg gcacaggaaa   1055

 tacga                                                               1060




      <210> 359
      <211> 938
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(937)

      <400> 359
 gatttcgtgg ggaagggagc cgccgccgca gccgccgcct ttgtggagta cttttgtcgg     60

 gaac atg gat gag aaa tcc aac aag ctg ctg cta gct ttg gtg atg ctc     109
      Met Asp Glu Lys Ser Asn Lys Leu Leu Leu Ala Leu Val Met Leu
        1               5                  10                  15

 ttc cta ttt gcc gtg atc gtc ctc caa tac gtg tgc ccc ggc aca gaa      157
 Phe Leu Phe Ala Val Ile Val Leu Gln Tyr Val Cys Pro Gly Thr Glu
                  20                  25                  30

 tgc cag ctc ctc cgc ctg cag gcg ttc agc tcc ccg gtg ccg gac ccg      205
 Cys Gln Leu Leu Arg Leu Gln Ala Phe Ser Ser Pro Val Pro Asp Pro
              35                  40                  45

 tac cgc tcg gag gat gag agc tcc gcc agg ttc gtg ccc cgc tac aat      253
 Tyr Arg Ser Glu Asp Glu Ser Ser Ala Arg Phe Val Pro Arg Tyr Asn
          50                  55                  60

 ttc acc cgc ggc gac ctc ctg cgc aag gta gac ttc gac atc aag ggc      301
 Phe Thr Arg Gly Asp Leu Leu Arg Lys Val Asp Phe Asp Ile Lys Gly
      65                  70                  75

 gat gac ctg atc gtg ttc ctg cac atc cag aag acc ggg ggc acc act      349
 Asp Asp Leu Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr
  80                  85                  90                  95

 ttc ggc cgc cac ttg gtg cgt aac atc cag ctg gag cag ccg tgc gag      397
 Phe Gly Arg His Leu Val Arg Asn Ile Gln Leu Glu Gln Pro Cys Glu
                 100                 105                 110

 tgc cgc gtg ggt cag aag aaa tgc act tgc cac cgg ccg ggt aag cgg      445
 Cys Arg Val Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys Arg
             115                 120                 125

 gaa acc tgg ctc ttc tcc agg ttc tcc acg ggc tgg agc tgc ggg ttg      493
 Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu
         130                 135                 140

 cac gcc gac tgg acc gag ctc acc agc tgt gtg ccc tcc gtg gtg gac      541
 His Ala Asp Trp Thr Glu Leu Thr Ser Cys Val Pro Ser Val Val Asp
     145                 150                 155

 ggc aag cgc gac gcc agg ctg aga ccg tcc agg tgg agg att ttt cag      589
 Gly Lys Arg Asp Ala Arg Leu Arg Pro Ser Arg Trp Arg Ile Phe Gln
 160                 165                 170                 175

 att cta gat gca gca agt aag gat aaa cgg ggt tct cca aac act aac      637
 Ile Leu Asp Ala Ala Ser Lys Asp Lys Arg Gly Ser Pro Asn Thr Asn
                 180                 185                 190

 gca ggc gcc aac tct ccg tca tcc aca aag acc cgg aac aca tct aag      685
 Ala Gly Ala Asn Ser Pro Ser Ser Thr Lys Thr Arg Asn Thr Ser Lys
             195                 200                 205

 agt ggg aag aac ttc cac tac atc acc atc ctc cga gac cca gtg tcc      733
 Ser Gly Lys Asn Phe His Tyr Ile Thr Ile Leu Arg Asp Pro Val Ser
         210                 215                 220

 cgg tac ttg agt gag tgg agg cat gtc cag aga ggg gca aca tgg aaa      781
 Arg Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp Lys
     225                 230                 235

 gca tcc ctg cat gtc tgc gat gga agg cct cca acc tcc gaa gag ctg      829
 Ala Ser Leu His Val Cys Asp Gly Arg Pro Pro Thr Ser Glu Glu Leu
 240                 245                 250                 255

 ccc agc tgc tac act ggc gat gac tgg tct ggc tgc ccc ctc aaa gag      877
 Pro Ser Cys Tyr Thr Gly Asp Asp Trp Ser Gly Cys Pro Leu Lys Glu
                 260                 265                 270

 ttt atg gac tgt ccc tac aat cta gcc aac aac cgc cag tgc gca tgc      925
 Phe Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Cys Ala Cys
             275                 280                 285

 tct ccg acc tga c                                                    938
 Ser Pro Thr 
         290





      <210> 360
      <211> 1032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(942)

      <400> 360
 ggcaagtcct ctgaggtcct ctcggccacc gagctcaggg tccagctggc ccagaaggag     60

 caggagctag ccagagccaa agaagccttg caggcc  atg aaa gct gat cgg aag     114
                                          Met Lys Ala Asp Arg Lys
                                            1               5

 cgc tta aag ggc gag aag aca gac ctg gtg agc cag atg cag cag ctg      162
 Arg Leu Lys Gly Glu Lys Thr Asp Leu Val Ser Gln Met Gln Gln Leu
              10                  15                  20

 tat gcc aca ctg gag agc cgc gag gag cag ctc cga gac ttc atc cgc      210
 Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln Leu Arg Asp Phe Ile Arg
          25                  30                  35

 aac tat gag cag cac cgc aag gag agc gag gat gcg gtc aaa gcg ctg      258
 Asn Tyr Glu Gln His Arg Lys Glu Ser Glu Asp Ala Val Lys Ala Leu
      40                  45                  50

 gcc aag gag aag gac ctg ctg gag cgt gag aag tgg gag ctg cgg cgc      306
 Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu Lys Trp Glu Leu Arg Arg
  55                  60                  65                  70

 caa gcc aag gag gcc aca gac cac gcc acg gca ctg cgc tcc cag ctg      354
 Gln Ala Lys Glu Ala Thr Asp His Ala Thr Ala Leu Arg Ser Gln Leu
                  75                  80                  85

 gac ctc aag gac aac cgg atg aag gag ctg gag gcc gag ctg gcc atg      402
 Asp Leu Lys Asp Asn Arg Met Lys Glu Leu Glu Ala Glu Leu Ala Met
              90                  95                 100

 gcc aaa cag tcc tta gct acg ctg acc aag gac gtc ccc aag cgg cat      450
 Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys Asp Val Pro Lys Arg His
         105                 110                 115

 tcc ctc gcc atg ccg ggc gag acg gtg ctc aat ggc aac cag gag tgg      498
 Ser Leu Ala Met Pro Gly Glu Thr Val Leu Asn Gly Asn Gln Glu Trp
     120                 125                 130

 gtg gtg cag gcg gac ctc ccg ctg acc gca gcc atc cgg cag agt caa      546
 Val Val Gln Ala Asp Leu Pro Leu Thr Ala Ala Ile Arg Gln Ser Gln
 135                 140                 145                 150

 cag act ctc tac cac tca cac ccc cct cac cct gcg gac cgg caa gcg      594
 Gln Thr Leu Tyr His Ser His Pro Pro His Pro Ala Asp Arg Gln Ala
                 155                 160                 165

 gtc agg gtg agc ccc tgc cac tcc cgg cag ccc tct gtc atc tcc gac      642
 Val Arg Val Ser Pro Cys His Ser Arg Gln Pro Ser Val Ile Ser Asp
             170                 175                 180

 gca tct gcc gcc gaa ggc gac cgg tcg tcc aca ccg agc gac atc aac      690
 Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser Thr Pro Ser Asp Ile Asn
         185                 190                 195

 tcc cct cga cac cgg aca cac tcc ctc tgc aac ggc gac agt ccc ggc      738
 Ser Pro Arg His Arg Thr His Ser Leu Cys Asn Gly Asp Ser Pro Gly
     200                 205                 210

 cca gtt cag aag aac ctg cac aac cct att gta cag tca cta gag gat      786
 Pro Val Gln Lys Asn Leu His Asn Pro Ile Val Gln Ser Leu Glu Asp
 215                 220                 225                 230

 ctt gaa gac caa aaa cgg aaa aag aag aaa gag aag atg gga ttc ggc      834
 Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys Glu Lys Met Gly Phe Gly
                 235                 240                 245

 tcc atc tcc cgc gtc ttc gcc aga ggg aag cag cgg aag tcc ctc gac      882
 Ser Ile Ser Arg Val Phe Ala Arg Gly Lys Gln Arg Lys Ser Leu Asp
             250                 255                 260

 ccc ggc ctc ttt gat ggt acc gcc cct gat tat tac ata gag gag gac      930
 Pro Gly Leu Phe Asp Gly Thr Ala Pro Asp Tyr Tyr Ile Glu Glu Asp
         265                 270                 275

 gcg gac tgg tga tac gcgctcccct gcgcctgctg cccgcaggcg tgtctgtgcg      985
 Ala Asp Trp 
     280

 tgtgggcgtg tgtgcaagcg agcgtgggtg cgcgtgtggc ccgtgcg                 1032




      <210> 361
      <211> 661
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(351)

      <400> 361
 taccggtccg gaattcccgg gtcgacgatt tcgtagaggg tttctcgctc tagggagatt     60

 cttcaagtta tctct atg tca aca gac aca ggt gtt tcc ctt cct tca tat     111
                  Met Ser Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr
                    1               5                  10

 gag gaa gat cag gga tca aaa ctc att cga aaa act aaa gag gca cca      159
 Glu Glu Asp Gln Gly Ser Lys Leu Ile Arg Lys Thr Lys Glu Ala Pro
          15                  20                  25

 ttc gta ccc gtt gga gag cgg aat ggg cat ctc tgt gca gaa cgt ttg      207
 Phe Val Pro Val Gly Glu Arg Asn Gly His Leu Cys Ala Glu Arg Leu
      30                  35                  40

 gtc cac aaa act ttt tta aaa ata tac tcc aga aga ttt aaa atc tcc      255
 Val His Lys Thr Phe Leu Lys Ile Tyr Ser Arg Arg Phe Lys Ile Ser
  45                  50                  55                  60

 agc gca ctc gag atc gtg ctc gct tgg atc cag ccc agc gcg cca tca      303
 Ser Ala Leu Glu Ile Val Leu Ala Trp Ile Gln Pro Ser Ala Pro Ser
                  65                  70                  75

 gcg cct ctg tca ctt tca gaa ctc ttg gcg ccc cct cgg ccc ccg tag      351
 Ala Pro Leu Ser Leu Ser Glu Leu Leu Ala Pro Pro Arg Pro Pro 
              80                  85                  90

 agtagcgttg aaaacgcgca agtgacgtcg cttgtttccc tggtgacggt tgccagggca    411

 gcgcgtgtcg gcgtccggag gaggtgacct agccgccgcg gtcctattga agtacatctt    471

 gtttttttct catttttggt aattatgaat aaagttattg agtccggaat tgtgggttct    531

 tggtctcact gacttcaaga acaaagccgc agaccctcgc ggtgagtgtt attacagttc    591

 ttaaaggtgg cgtgtctgga gtttgtttct tccttctgat gtcaagatgt gttcagagtt    651

 tcttccagtt                                                           661




      <210> 362
      <211> 1126
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(1072)

      <400> 362
 ctcccgggtc gacgatttcg tcagccttct ggagatggcg tgcgcagccg gggatggggg     60

 cgactggaag ggggtgcccg tggcttcctt tgggcctttc cttccaacta gcgcctgcag    120

 gtggacccgg gttgacttcc ctcacctccc tcgggcggcc gacctttgga tggcggacct    180

 cagccgcccc agggttgcga ggcgacgggc gcgctggccc aggccaccag gcgggctcca    240

 tcagggcttt gggtggtgag ttgggggcgc cggatttggc tcatttcaac gctggccgga    300

 ggtcacgagg   atg gag ttc agg aca aag agg tgt ggg cag gcc act ggg     349
              Met Glu Phe Arg Thr Lys Arg Cys Gly Gln Ala Thr Gly
                1               5                  10

 cca gct ggt aac atc atg gca gag aaa gtg aac aac ttc cca cca ttg      397
 Pro Ala Gly Asn Ile Met Ala Glu Lys Val Asn Asn Phe Pro Pro Leu
      15                  20                  25

 ccc aaa ttc atc ccg ctg aag cca tgt ttc tac caa gac ttc gag gca      445
 Pro Lys Phe Ile Pro Leu Lys Pro Cys Phe Tyr Gln Asp Phe Glu Ala
  30                  35                  40                  45

 gat att cct ccc cag cat gtc agc atg acc aag cgc ctc tac tac ctc      493
 Asp Ile Pro Pro Gln His Val Ser Met Thr Lys Arg Leu Tyr Tyr Leu
                  50                  55                  60

 tgg atg ttg aac agc gtc acg ctg gcc gtg aac ctg gtg ggc tgt ctc      541
 Trp Met Leu Asn Ser Val Thr Leu Ala Val Asn Leu Val Gly Cys Leu
              65                  70                  75

 gcg tgg ctg atc gga ggc ggg gga gcc acc aac ttt ggc ctc gcc ttt      589
 Ala Trp Leu Ile Gly Gly Gly Gly Ala Thr Asn Phe Gly Leu Ala Phe
          80                  85                  90

 ctc tgg ctc atc ctc ttc aca ccc tgc tcc tac gtc tgc tgg ttt cgg      637
 Leu Trp Leu Ile Leu Phe Thr Pro Cys Ser Tyr Val Cys Trp Phe Arg
      95                 100                 105

 ccc att tac aag gcc ttc aag act gac agc tcc ttc agt ttc atg gca      685
 Pro Ile Tyr Lys Ala Phe Lys Thr Asp Ser Ser Phe Ser Phe Met Ala
 110                 115                 120                 125

 ttc ttc ttt acc ttc atg gct cag ttg gtc atc agc atc atc cag gcc      733
 Phe Phe Phe Thr Phe Met Ala Gln Leu Val Ile Ser Ile Ile Gln Ala
                 130                 135                 140

 gtg ggc atc cca ggc tgg ggc gtc tgc ggc tgg att gct acc atc tcc      781
 Val Gly Ile Pro Gly Trp Gly Val Cys Gly Trp Ile Ala Thr Ile Ser
             145                 150                 155

 ttc ttc gga acg aac att ggc tcg gcg gtg gtg atg cta att ccc act      829
 Phe Phe Gly Thr Asn Ile Gly Ser Ala Val Val Met Leu Ile Pro Thr
         160                 165                 170

 gtc atg ttc aca gtg atg gcc gtc ttt tcc ttc atc gcc ctc agc atg      877
 Val Met Phe Thr Val Met Ala Val Phe Ser Phe Ile Ala Leu Ser Met
     175                 180                 185

 gtt cat aaa ttt tac cgg gga agt ggg ggg agt ttc agc aaa gct cag      925
 Val His Lys Phe Tyr Arg Gly Ser Gly Gly Ser Phe Ser Lys Ala Gln
 190                 195                 200                 205

 gag gag tgg acc aca ggg gcc tgg aag aat cca cat gtg cag cag gca      973
 Glu Glu Trp Thr Thr Gly Ala Trp Lys Asn Pro His Val Gln Gln Ala
                 210                 215                 220

 gcc cag aac gca gcc atg ggg gca gcc cag ggt gcc atg aat cag cct     1021
 Ala Gln Asn Ala Ala Met Gly Ala Ala Gln Gly Ala Met Asn Gln Pro
             225                 230                 235

 cag act cag tat tcc gcc acc ccc aat tac acg tac tcc aat gag atg     1069
 Gln Thr Gln Tyr Ser Ala Thr Pro Asn Tyr Thr Tyr Ser Asn Glu Met
         240                 245                 250

 tga acca gccacgccta ccaggtggca gagctggggc cattgggaca gggggctcaa     1126
 






      <210> 363
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(502)

      <400> 363
 aactggagcg agtagcgcgc ggcgtggaac gcgagtcgcg accccggctc ccggcagtgg     60

 cgcgcactag ccctcgcgcc gcacgggaca cgagggctgg gcgggcagcg gg    atg     115
                                                              Met
                                                                1

 agg cta aag gtt gga ttt caa ggc ggg ggc tgc ttc cgg aaa gac gcg      163
 Arg Leu Lys Val Gly Phe Gln Gly Gly Gly Cys Phe Arg Lys Asp Ala
               5                  10                  15

 ctg tgt ttg gaa ggt gga gtg agc gcc cgg tgg gcg agg gca cct cat      211
 Leu Cys Leu Glu Gly Gly Val Ser Ala Arg Trp Ala Arg Ala Pro His
          20                  25                  30

 tct gca ccc ctg cgc ccg cct cgg gaa ctg cac gcg gca ccc cca ccc      259
 Ser Ala Pro Leu Arg Pro Pro Arg Glu Leu His Ala Ala Pro Pro Pro
      35                  40                  45

 gcg act ccc acg cag aca gta gtg cgg cct gca ggg ttc ccc cgg cgg      307
 Ala Thr Pro Thr Gln Thr Val Val Arg Pro Ala Gly Phe Pro Arg Arg
  50                  55                  60                  65

 acg agg cta atg gtt cgc tcc gcc ccg ccc aca cag agg ccg ccc act      355
 Thr Arg Leu Met Val Arg Ser Ala Pro Pro Thr Gln Arg Pro Pro Thr
                  70                  75                  80

 ggc tcc ggc tgc gtt tca gga ctc tgg agg aag gga ctt ggc ctt cgc      403
 Gly Ser Gly Cys Val Ser Gly Leu Trp Arg Lys Gly Leu Gly Leu Arg
              85                  90                  95

 cct cag acg ctc tta agg gta ggc ggc gtt gtc ctc agt tct gcc cca      451
 Pro Gln Thr Leu Leu Arg Val Gly Gly Val Val Leu Ser Ser Ala Pro
         100                 105                 110

 gca ctc aga ccc aga ctg ggt ccc tgc ctc cgc cct ccg ccc tcg gac      499
 Ala Leu Arg Pro Arg Leu Gly Pro Cys Leu Arg Pro Pro Pro Ser Asp
     115                 120                 125

 tag tctc ttggaagccg gcctgtctcc gccttcagac ctagggagag gtcttaacct      556
 


 ctgttctcag actctggaaa aggcttctca acggcttggc ctgacctcag ctcctcgcat    616

 tccctccaca tctcaagaca ccaacccagg gatgcaggac agacacacag acactcagtg    676

 agggtcaaat atctttaaat aaagtgccag gaacaataaa tactgtacag gaagagaaaa    736

 aaaaaaaa                                                             744




      <210> 364
      <211> 1916
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (952)..(1323)

      <400> 364
 aggtcaaaaa aaacagtttc acttacattt tcataaataa cttatgagga tttatttata     60

 attaaaatac gctagacttt atttgttcat ttgcaatgta agatttacaa atatatgaat    120

 ctaaaaatgc aagaaataga ctgaggatgt tagcatccca aactaaattt taatacctca    180

 caaattaaaa taaacgttaa aagattacca aaagttattt aagttgttgg taaagtatga    240

 ttgcaaattt actggtattg tcttaactga ttagctactt tttacagaaa ttattagtaa    300

 atattttctt ttaaatatct agctatgata ccttaacttc agaaaacaac ttagtctgga    360

 acacaacaat ttagttatac tgttcacttt tgtgaagtaa gagtttaact ttatgttaca    420

 attattggct gtactaattg taaactagta attctgtgag atactacaga ttaaaataat    480

 aaacaagaac agacgcggtg gctaggtaaa aaaagatggt aacgataatg cagagaaaaa    540

 aacagaactt taaaaaaaaa tcagatggct gggcgcaatg gcttacacct gtaatctcag    600

 cactctggaa ggccaaggca ggaacctgga ggccaggagt tgacaccagc ctgggcaagc    660

 tggggagacc ctgtctctac agaaaataaa gagagatgtg attgcaccac tgcactccag    720

 cctaggcaac agagtgagac cctgtctcaa aagaaaaaga aaataaatca gaaattggat    780

 tggcagctgc agttcttaag agtaagaatg gaacttcaaa gacaaaaaca taattttcgg    840

 cctggaattc tattctcagc caaaggaaaa attaattctt agggtaaatt taaaatattt    900

 tcaaaagcgc aaggtcacaa aaaatgtagt tcccatgcaa cctttttgaa g atg ata     957
                                                          Met Ile
                                                            1

 ctg gag aat atg ctc tgc caa aat cgg aaa gta aac caa gta gga ggc     1005
 Leu Glu Asn Met Leu Cys Gln Asn Arg Lys Val Asn Gln Val Gly Gly
           5                  10                  15

 aga cat aga ata tct tta aaa gag ctc caa ttt gag gga gat gca aag     1053
 Arg His Arg Ile Ser Leu Lys Glu Leu Gln Phe Glu Gly Asp Ala Lys
      20                  25                  30

 aga atc tct aag aag atg aca atc agt gat acc agg ggc ata ggt gca     1101
 Arg Ile Ser Lys Lys Met Thr Ile Ser Asp Thr Arg Gly Ile Gly Ala
  35                  40                  45                  50

 cat cag gtg gga agg tca acc aat cta gac tgg ggc tta tct gag ggt     1149
 His Gln Val Gly Arg Ser Thr Asn Leu Asp Trp Gly Leu Ser Glu Gly
                  55                  60                  65

 tcc agg agg aaa act cta ctc aag atg aaa ttg aca tat tac ttg ata     1197
 Ser Arg Arg Lys Thr Leu Leu Lys Met Lys Leu Thr Tyr Tyr Leu Ile
              70                  75                  80

 ctt ctg aat ata tta agg caa gta ttc atc tgt gaa tgg tgt tta cat     1245
 Leu Leu Asn Ile Leu Arg Gln Val Phe Ile Cys Glu Trp Cys Leu His
          85                  90                  95

 gat cat aac ata aac act gaa tac tgt tct aaa aac atg aca tca cta     1293
 Asp His Asn Ile Asn Thr Glu Tyr Cys Ser Lys Asn Met Thr Ser Leu
     100                 105                 110

 tat gtg gaa gat gaa atg aat aga aac tga t cagtggctaa ctgccagccc     1344
 Tyr Val Glu Asp Glu Met Asn Arg Asn 
 115                 120

 aaagatacgt gcttaatcct tatttccaaa gtgaaatggc aatagttaaa gcttaaaact   1404

 aaaatcaagg aatggccttg aaagtacata gaaatataaa agtaagcatg aaacagagaa   1464

 gagcaagaag aagttgcctc tggagagatg gaaatagaga aaagagtagg gaacatatat   1524

 aattttaata aaaataagaa aacaaaaata tctcccagta gtaaaagaca tgagttttca   1584

 gatttaaagg gtaaatctag aacttagcac aaggataaaa tgtcagaaac cagaagaata   1644

 aaaagaaaaa agcttccaga gggtttatgt acaaggcgaa ggataggtat acatgaaaag   1704

 caaaaggata tccaatttct caagagactt caaaattctg aagaaaacct atttctttct   1764

 tagaattttc tactgagcca acctatctat caagtatgag ggaaaaaata aagataattc   1824

 caggcaagca agatttcaaa aaacaattta gcaccctttc taaggacacc ataggagaat   1884

 gtactctgca ctctgcaaaa aagaaaaaga at                                 1916




      <210> 365
      <211> 13715
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(13139)

      <400> 365
 gcccggccct cccggtctcc accgtgtgtg tccgcgaggt ctgccgctgg tccagctggt     60

 acaatgggca ccgcccagag cccggcctgg gaggcggaga ctttgagacg tttgaaaacc    120

 tgaggcagag agggtaccag gtatgccctg tgctggctga catcgagtgc cgggcggcgc    180

 agcttcccga c atg ccg ctg gag gag ctg ggc cag cag gtg gac tgt gac     230
              Met Pro Leu Glu Glu Leu Gly Gln Gln Val Asp Cys Asp
                1               5                  10

 cgc atg cgg ggg ctg atg tgc gcc aac agc caa cag agt ccc ccg ctc      278
 Arg Met Arg Gly Leu Met Cys Ala Asn Ser Gln Gln Ser Pro Pro Leu
      15                  20                  25

 tgt cac gac tac gag ctg cgg gtt ctc tgc tgc gaa tac gtg ccc tgt      326
 Cys His Asp Tyr Glu Leu Arg Val Leu Cys Cys Glu Tyr Val Pro Cys
  30                  35                  40                  45

 ggc ccc tcc ccg gcc cca ggc acc agc cct cag ccc tcc ctc agt gcc      374
 Gly Pro Ser Pro Ala Pro Gly Thr Ser Pro Gln Pro Ser Leu Ser Ala
                  50                  55                  60

 agc acg gag cct gct gtg cct acc cca acc cag acc aca gca acc gaa      422
 Ser Thr Glu Pro Ala Val Pro Thr Pro Thr Gln Thr Thr Ala Thr Glu
              65                  70                  75

 aag acc acc cta tgg gtg acc ccg agc atc cgg tcg acg gcg gcc ctc      470
 Lys Thr Thr Leu Trp Val Thr Pro Ser Ile Arg Ser Thr Ala Ala Leu
          80                  85                  90

 acc tcg cag act ggg tcc agc tca ggc ccc gtg acg gtc acc ccc tcg      518
 Thr Ser Gln Thr Gly Ser Ser Ser Gly Pro Val Thr Val Thr Pro Ser
      95                 100                 105

 gcc cca ggt acc acc acc tgc cag ccc cgg tgt cag tgg aca gag tgg      566
 Ala Pro Gly Thr Thr Thr Cys Gln Pro Arg Cys Gln Trp Thr Glu Trp
 110                 115                 120                 125

 ttt gat gag gac tac ccc aag tct gaa caa ctt gga ggg gac gtt gag      614
 Phe Asp Glu Asp Tyr Pro Lys Ser Glu Gln Leu Gly Gly Asp Val Glu
                 130                 135                 140

 tcc tac gat aag atc agg gcc gct gga ggg cac tta tgc cag cag cct      662
 Ser Tyr Asp Lys Ile Arg Ala Ala Gly Gly His Leu Cys Gln Gln Pro
             145                 150                 155

 aag gac ata gag tgc cag gcc gag agc ttc ccc aac tgg acc ctg gca      710
 Lys Asp Ile Glu Cys Gln Ala Glu Ser Phe Pro Asn Trp Thr Leu Ala
         160                 165                 170

 cag gtg ggg cag aag gtg cac tgt gac gtc cac ttc ggc ctg gtg tgc      758
 Gln Val Gly Gln Lys Val His Cys Asp Val His Phe Gly Leu Val Cys
     175                 180                 185

 agg aac tgg gag cag gag ggc gtc ttc aag atg tgc tac aac tac agg      806
 Arg Asn Trp Glu Gln Glu Gly Val Phe Lys Met Cys Tyr Asn Tyr Arg
 190                 195                 200                 205

 atc cgg gtc ctc tgc tgc agc gac gac cac tgc agg gga cgt gcc aca      854
 Ile Arg Val Leu Cys Cys Ser Asp Asp His Cys Arg Gly Arg Ala Thr
                 210                 215                 220

 acc ccg cca ccg acc aca gag ctg gag acg gcc acc acc acc acc acc      902
 Thr Pro Pro Pro Thr Thr Glu Leu Glu Thr Ala Thr Thr Thr Thr Thr
             225                 230                 235

 cag gcc ctg ttc tca acg ccg cag cct acg agt agc ccg ggg ctg acc      950
 Gln Ala Leu Phe Ser Thr Pro Gln Pro Thr Ser Ser Pro Gly Leu Thr
         240                 245                 250

 agg gct ccc ccg gcc agc acc aca gca gtc ccc acc ctc tca gaa gga      998
 Arg Ala Pro Pro Ala Ser Thr Thr Ala Val Pro Thr Leu Ser Glu Gly
     255                 260                 265

 ctg aca tcc ccc aga tac aca agc acc ctt ggt aca gcc acc acg gga     1046
 Leu Thr Ser Pro Arg Tyr Thr Ser Thr Leu Gly Thr Ala Thr Thr Gly
 270                 275                 280                 285

 ggc cca cga cag tct gca ggc tcc aca gaa ccc act gtc cca ggg gtg     1094
 Gly Pro Arg Gln Ser Ala Gly Ser Thr Glu Pro Thr Val Pro Gly Val
                 290                 295                 300

 gcc aca tcc acc ctt cca aca cgc tca gcc ctt cca ggg acg acg ggg     1142
 Ala Thr Ser Thr Leu Pro Thr Arg Ser Ala Leu Pro Gly Thr Thr Gly
             305                 310                 315

 agc ttg ggc aca tgg cgc ccc tca cag cca ccc acg ctg gcc cca aca     1190
 Ser Leu Gly Thr Trp Arg Pro Ser Gln Pro Pro Thr Leu Ala Pro Thr
         320                 325                 330

 aca atg gca acc tcc aga gct cgc ccg aca ggc aca gcc agc acc gct     1238
 Thr Met Ala Thr Ser Arg Ala Arg Pro Thr Gly Thr Ala Ser Thr Ala
     335                 340                 345

 tcc aaa gag ccg ctg acc acg agc ctg gcg cca aca ctc acg agc gag     1286
 Ser Lys Glu Pro Leu Thr Thr Ser Leu Ala Pro Thr Leu Thr Ser Glu
 350                 355                 360                 365

 ctg tcc acc tct cag gcc gag acc agc acg ccc agg aca gag acg aca     1334
 Leu Ser Thr Ser Gln Ala Glu Thr Ser Thr Pro Arg Thr Glu Thr Thr
                 370                 375                 380

 atg agc ccc ttg act aac acc acc acc agc cag ggc acg acc cgc tgt     1382
 Met Ser Pro Leu Thr Asn Thr Thr Thr Ser Gln Gly Thr Thr Arg Cys
             385                 390                 395

 caa ccg aag tgt gag tgg aca gag tgg ttt gac gtg gac ttc cca acc     1430
 Gln Pro Lys Cys Glu Trp Thr Glu Trp Phe Asp Val Asp Phe Pro Thr
         400                 405                 410

 tca ggg gtt gca agc ggg gac atg gaa act ttt gaa aac atc agg gct     1478
 Ser Gly Val Ala Ser Gly Asp Met Glu Thr Phe Glu Asn Ile Arg Ala
     415                 420                 425

 gct ggg ggc aag atg tgc tgg gca cca aag agc ata gag tgc cgg gcg     1526
 Ala Gly Gly Lys Met Cys Trp Ala Pro Lys Ser Ile Glu Cys Arg Ala
 430                 435                 440                 445

 gag aac tac ccc gag gta agc atc gac cag gtc ggg cag gtg ctg acc     1574
 Glu Asn Tyr Pro Glu Val Ser Ile Asp Gln Val Gly Gln Val Leu Thr
                 450                 455                 460

 tgc agc ctg gag acg ggg ctg acc tgc aag aac gaa gac cag aca ggc     1622
 Cys Ser Leu Glu Thr Gly Leu Thr Cys Lys Asn Glu Asp Gln Thr Gly
             465                 470                 475

 agg ttc aac atg tgc ttc aac tac aac gtg cgt gtg ctt tgc tgt gac     1670
 Arg Phe Asn Met Cys Phe Asn Tyr Asn Val Arg Val Leu Cys Cys Asp
         480                 485                 490

 gac tac agc cac tgc ccc agt acc cta gcc acc agc tcc acg gcc acg     1718
 Asp Tyr Ser His Cys Pro Ser Thr Leu Ala Thr Ser Ser Thr Ala Thr
     495                 500                 505

 ccc tcc tca act ccg ggg acg acc tgg atc ctc aca aag ccg acc aca     1766
 Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Pro Thr Thr
 510                 515                 520                 525

 aca gcc act acg act gcg tcc act gga tcc acg gcc acc gcc tcc tcc     1814
 Thr Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Ala Ser Ser
                 530                 535                 540

 acc cag gca act gct ggc acc cca cat gtg agc acc acg gcc acg aca     1862
 Thr Gln Ala Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr
             545                 550                 555

 ccc aca gtc acc agc tcc aaa gcc act ccc ttc tcc agt cca ggg act     1910
 Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr
         560                 565                 570

 gca acc gcc ctt cca gca ctg aga agc aca gcc acc aca ccc aca gct     1958
 Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala
     575                 580                 585

 acc agc ttt aca gcc atc ccc tcc tcc tcc ctg ggc acc acc tgg acc     2006
 Thr Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr
 590                 595                 600                 605

 cgc cta tca cag acc acc aca ccc atg gcc acc atg tcc aca gcc aca     2054
 Arg Leu Ser Gln Thr Thr Thr Pro Met Ala Thr Met Ser Thr Ala Thr
                 610                 615                 620

 ccc tcc tcc act cca gag act gtc cac acc tcc aca gtg ctt acc acc     2102
 Pro Ser Ser Thr Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr
             625                 630                 635

 acg gcc acc aca acc ggg gcc acc ggc tct gtg gcc acc ccc tcc tcc     2150
 Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser
         640                 645                 650

 acc cca gga aca gct cac act acc aaa gtg ctg act acc aca acc acg     2198
 Thr Pro Gly Thr Ala His Thr Thr Lys Val Leu Thr Thr Thr Thr Thr
     655                 660                 665

 ggc ttc aca gcc acc ccc tcc tcc agc cca ggg agg gca cgc acg ctt     2246
 Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Arg Ala Arg Thr Leu
 670                 675                 680                 685

 cca gtg tgg atc agc aca acc acc aca ccc aca acc aga ggt tcc acg     2294
 Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr
                 690                 695                 700

 gtg acc ccc tcc tcc atc ccg ggg acc acc cac acc ccc aca gtg ctg     2342
 Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr Pro Thr Val Leu
             705                 710                 715

 acc acc acc acc aca act gtg gcc act ggt tct atg gca aca ccc tcc     2390
 Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser
         720                 725                 730

 tct agc aca cag acc agt ggt act ccc cca tca ctg acc acc acg gcc     2438
 Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala
     735                 740                 745

 act acg atc acg gcc acc ggc tcc acc acc aac ccc tcc tca act cca     2486
 Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro
 750                 755                 760                 765

 ggg aca aca cct atc ccc cca gtg ctg acc acc acc gcc acc aca cct     2534
 Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro
                 770                 775                 780

 gca gcc acc agc agc aca gtg act ccc tcc tct gcc cta ggg acc acc     2582
 Ala Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr
             785                 790                 795

 cac aca ccc cca gtg ccg aac acc acg gcc acc aca cac ggg cga tcc     2630
 His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser
         800                 805                 810

 ctg tcc ccc agc agt ccc cac acg gtg tgc aca gcc tgg act tcg gcc     2678
 Leu Ser Pro Ser Ser Pro His Thr Val Cys Thr Ala Trp Thr Ser Ala
     815                 820                 825

 acc tcg ggc atc ttg ggc acc acc cac atc aca gag cct tcc acg ggg     2726
 Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly
 830                 835                 840                 845

 act tcc cac acc cca gca gca acc acc ggt acc acc cag cac tcg act     2774
 Thr Ser His Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr
                 850                 855                 860

 cca gcc ctt tcc agc cct cac cct agc agc aga acc acc gag tca ccc     2822
 Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro
             865                 870                 875

 cct tct cca ggg acg acc acc ccg ggc cac acc acg gcc acc tcc agg     2870
 Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg
         880                 885                 890

 acc aca gcc acg gcc aca ccc agc aag acc cgc acc tcg acc ctg ctg     2918
 Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu
     895                 900                 905

 ccc agc cag ccc aca tcg gcc ccc ata acc acg gtg gtg acc atg ggc     2966
 Pro Ser Gln Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly
 910                 915                 920                 925

 tgt gag ccc cag tgt gcc tgg tca gag tgg ctg gac tac agc tac ccc     3014
 Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro
                 930                 935                 940

 atg ccg ggg ccc tct ggc ggg gac ttt gac acc tac tcc aac atc cgt     3062
 Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg
             945                 950                 955

 gcg gcc gga ggg gcc gtc tgt gag cag ccc ctg ggc ctc gag tgc cgt     3110
 Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg
         960                 965                 970

 gcc cag gcc cag cct ggt gtc ccc ctg cgg gag ttg ggc cag gtc gtg     3158
 Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val
     975                 980                 985

 gaa tgc agc ctg gac ttt ggc ctg gtc tgc agg aac cgt gag cag gtg     3206
 Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val
 990                 995                1000                1005

 ggg aag ttc aag atg tgc ttc aac tat gaa atc cgt gtg ttc tgc tgc     3254
 Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys
                1010                1015                1020

 aac tac ggc cac tgc ccc agc acc ccg gcc acc agc tct acg gcc acg     3302
 Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr
            1025                1030                1035

 ccc tcc tcc act cca ggg acg acc tgg atc ctc aca gag ctg acc aca     3350
 Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr
        1040                1045                1050

 aca gcc act acg act gag tcc act gga tcc acg gcc acc ccg acc tcc     3398
 Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro Thr Ser
    1055                1060                1065

 acc ctg aga aca gct ccc cct ccc aaa gtg ctg acc acc acg gcc acc     3446
 Thr Leu Arg Thr Ala Pro Pro Pro Lys Val Leu Thr Thr Thr Ala Thr
1070                1075                1080                1085

 aca ccc aca gtc acc agc tcc aaa gcc act ccc tcc tcc agt cca ggg     3494
 Thr Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Ser Ser Ser Pro Gly
                1090                1095                1100

 act gca acc gcc ctt cca gca ctg aga agc aca gcc acc aca ccc aca     3542
 Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr
            1105                1110                1115

 gct acc agc gtt aca ccc atc ccc tct tcc tcc ctg ggc acc acc tgg     3590
 Ala Thr Ser Val Thr Pro Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp
        1120                1125                1130

 acc cgc cta tca cag acc acc aca ccc acg gcc acc atg tcc aca gcc     3638
 Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala
    1135                1140                1145

 aca ccc tcc tcc act cca gag act gcc cac acc tcc aca gtg ctt acc     3686
 Thr Pro Ser Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr
1150                1155                1160                1165

 gcc acg gcc acc aca act ggg gcc acc ggc tct gtg gcc acc ccc tcc     3734
 Ala Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser
                1170                1175                1180

 tcc acc cca gga aca gct cac act acc aaa gtg cca act acc aca acc     3782
 Ser Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr
            1185                1190                1195

 acg ggc ttc aca gcc acc ccc tcc tcc agc cca ggg acg gca ctc acg     3830
 Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr
        1200                1205                1210

 cct cca gtg tgg atc agc aca acc acc aca ccc aca acc aga ggc tcc     3878
 Pro Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser
    1215                1220                1225

 acg gtg acc ccc tcc tcc atc ccg ggg acc acc cac acc gcc aca gtg     3926
 Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr Ala Thr Val
1230                1235                1240                1245

 ctg acc acc acc acc aca act gtg gcc act ggt tct atg gca aca ccc     3974
 Leu Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro
                1250                1255                1260

 tcc tct agc aca cag acc agt ggt act ccc cca tca ctg acc acc acg     4022
 Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr
            1265                1270                1275

 gcc act acg atc acg gcc acc ggc tcc acc acc aac ccc tcc tca act     4070
 Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr
        1280                1285                1290

 cca ggg aca aga cct atc ccc cca gtg ctg acc acc acc gcc acc aca     4118
 Pro Gly Thr Arg Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr
    1295                1300                1305

 cct gca gcc acc agc agc aca gtg act ccc tcc tct gcc cta ggg acc     4166
 Pro Ala Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr
1310                1315                1320                1325

 acc cac aca ccc cca gtg ccg aac acc acg gca acc aca cac ggg cga     4214
 Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg
                1330                1335                1340

 tcc ctg tcc ccc agc agt ccc cac acg gtg cgc aca gcc tgg act tcg     4262
 Ser Leu Ser Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser
            1345                1350                1355

 gcc acc tca ggc acc ttg ggc acc acc cac atc aca gag cct tcc acg     4310
 Ala Thr Ser Gly Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr
        1360                1365                1370

 ggg act tcc cac acc cca gca gca acc acc ggt acc acc cag cac tcg     4358
 Gly Thr Ser His Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser
    1375                1380                1385

 act cca gcc ctt tcc agc cct cac cct agc agc aga acc acc gag tca     4406
 Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser
1390                1395                1400                1405

 ccc cct tct cca ggg acg acc acc ccg ggc cac acc acg gcc acc tcc     4454
 Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser
                1410                1415                1420

 agg acc aca gcc acg gcc aca ccc agc aag acc cgc acc tcg acc ctg     4502
 Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu
            1425                1430                1435

 ctg ccc agc agc ccc aca tcg gcc ccc ata acc acg gtg gtg acc atg     4550
 Leu Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met
        1440                1445                1450

 ggc tgt gag ccc cag tgt gcc tgg tca gag tgg ctg gac tac agc tac     4598
 Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr
    1455                1460                1465

 ccc atg ccg ggg ccc tct ggc ggg gac ttt gac acc tac tcc aac atc     4646
 Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile
1470                1475                1480                1485

 cgt gcg gcc gga ggg gcc gtc tgt gag cag ccc ctg ggc ctc gag tgc     4694
 Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys
                1490                1495                1500

 cgt gcc cag gcc cag cct ggt gtc ccc ctg cgg gag ttg ggc cag gtc     4742
 Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val
            1505                1510                1515

 gtg gaa tgc agc ctg gac ttt ggc ctg gtc tgc agg aac cgt gag cag     4790
 Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln
        1520                1525                1530

 gtg ggg aag ttc aag atg tgc ttc aac tat gaa atc cgt gtg ttc tgc     4838
 Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys
    1535                1540                1545

 tgc aac tac ggc cac tgc ccc agc acc ccg gcc acc agc tct acg gcc     4886
 Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala
1550                1555                1560                1565

 acg ccc tcc tcc act cca ggg acg acc tgg atc ctc aca gag cag acc     4934
 Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Gln Thr
                1570                1575                1580

 aca gca gcc act acg acc gca acc act gga tcc acg gcc atc ccg tcc     4982
 Thr Ala Ala Thr Thr Thr Ala Thr Thr Gly Ser Thr Ala Ile Pro Ser
            1585                1590                1595

 tcc acc ccg gga aca gct ccc cct ccc aaa gtg ctg acc agc cag gcc     5030
 Ser Thr Pro Gly Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Gln Ala
        1600                1605                1610

 acc aca ccc aca gcc acc agt tcc aaa gcc act tcc tcc tcc agt cca     5078
 Thr Thr Pro Thr Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro
    1615                1620                1625

 agg act gca acc acc ctt cca gtg ctg aca agc aca gcc acc aaa tcc     5126
 Arg Thr Ala Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser
1630                1635                1640                1645

 aca gct acc agc ttt aca ccc atc ccc tcc tcc acc ctt ggg acc acc     5174
 Thr Ala Thr Ser Phe Thr Pro Ile Pro Ser Ser Thr Leu Gly Thr Thr
                1650                1655                1660

 ggg acc tcc cag aac aga cca cca cac ccc atg gcc acc atg tcc aca     5222
 Gly Thr Ser Gln Asn Arg Pro Pro His Pro Met Ala Thr Met Ser Thr
            1665                1670                1675

 atc cac ccc tcc tcc act ccg gag acc acc cac acc tcc aca gtg ctg     5270
 Ile His Pro Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu
        1680                1685                1690

 acc aca aag gcc acc acg aca agg gcc acc agt tcc atg tcc acc ccc     5318
 Thr Thr Lys Ala Thr Thr Thr Arg Ala Thr Ser Ser Met Ser Thr Pro
    1695                1700                1705

 tcc tcc act ccg ggg acg acc tgg atc ctc aca gag ctg acc aca gca     5366
 Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala
1710                1715                1720                1725

 gcc act aca act gca gca ctg ccc cac ggc acc ccg tcc tcc acc cca     5414
 Ala Thr Thr Thr Ala Ala Leu Pro His Gly Thr Pro Ser Ser Thr Pro
                1730                1735                1740

 ggg acc acc tgg atc ctc aca gag ccc agc act aca gcc acc gtg acg     5462
 Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr
            1745                1750                1755

 gtg ccc acc gga tcc acg gcc acc gcc tcc tcc acc cgg gca act gct     5510
 Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr Arg Ala Thr Ala
        1760                1765                1770

 ggc acc ctc aaa gtg ctg acc agc acg gcc acc aca ccc aca gtc atc     5558
 Gly Thr Leu Lys Val Leu Thr Ser Thr Ala Thr Thr Pro Thr Val Ile
    1775                1780                1785

 agc tcc aga gcc act ccc tcc tcc agt cca ggg act gca acc gcc ctt     5606
 Ser Ser Arg Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu
1790                1795                1800                1805

 cca gca ctg aga agc aca gcc acc aca ccc aca gct acc agc gtt aca     5654
 Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Val Thr
                1810                1815                1820

 gcc atc ccc tct tcc tcc ctg ggc acc gcc tgg acc cgc cta tca cag     5702
 Ala Ile Pro Ser Ser Ser Leu Gly Thr Ala Trp Thr Arg Leu Ser Gln
            1825                1830                1835

 acc acc aca ccc acg gcc acc atg tcc aca gcc aca ccc tcc tcc act     5750
 Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr
        1840                1845                1850

 cca gag act gtc cac acc tcc aca gtg ctt acc acc acg gcc acc aca     5798
 Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Thr
    1855                1860                1865

 acc agg acc ggc tct gtg gcc acc ccc tcc tcc acc cca gga aca gct     5846
 Thr Arg Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala
1870                1875                1880                1885

 cac act acc aaa gtg ccg act acc aca acc acg ggc ttc aca gcc acc     5894
 His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr
                1890                1895                1900

 ccc tcc tcc agc cca ggg acg gca ctc acg cct cca gtg tgg atc agc     5942
 Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser
            1905                1910                1915

 aca acc acc aca ccc aca acc aga ggc tcc acg gtg acc ccc tcc tcc     5990
 Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser
        1920                1925                1930

 atc ccg ggg acc acc cac acc gcc aca gtg ctg acc acc acc acc aca     6038
 Ile Pro Gly Thr Thr His Thr Ala Thr Val Leu Thr Thr Thr Thr Thr
    1935                1940                1945

 act gtg gcc act ggt tct atg gca aca ccc tcc tct agc aca cag acc     6086
 Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr
1950                1955                1960                1965

 agt ggt act ccc cca tca ctg acc acc acg gcc act acg atc aca gcc     6134
 Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala
                1970                1975                1980

 acc ggc tcg acc acc aac ccc tcc tca act cca ggg aca act ccc atc     6182
 Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile
            1985                1990                1995

 ccc cca gtg ctg acc acc acc gcc acc aca cct gca gcc acc agc agc     6230
 Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser
        2000                2005                2010

 aca gtg act ccc tcc tct gcc cta ggg acc acc cac aca ccc cca gtg     6278
 Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val
    2015                2020                2025

 ccg aac acc acg gcc acc aca cac ggg cgg tcc ctg ccc ccc agc agt     6326
 Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Pro Pro Ser Ser
2030                2035                2040                2045

 ccc cac acg gtg ccc aca gcc tgg act tcg gcc acc tcg ggc atc ttg     6374
 Pro His Thr Val Pro Thr Ala Trp Thr Ser Ala Thr Ser Gly Ile Leu
                2050                2055                2060

 ggc acc acc cac atc aca gag cct tcc acg ggg act tcc cac acc cca     6422
 Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His Thr Pro
            2065                2070                2075

 gca gca acc acc ggt acc acc cag ccc tcg act cca gcc ctt tcc agc     6470
 Ala Ala Thr Thr Gly Thr Thr Gln Pro Ser Thr Pro Ala Leu Ser Ser
        2080                2085                2090

 cct cac cct agc agc agg acc acc gag tca ccc cct tct cca ggg acg     6518
 Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr
    2095                2100                2105

 acc acc ccg ggc cac acc agg ggc acc tcc agg acc aca gcc aca gcc     6566
 Thr Thr Pro Gly His Thr Arg Gly Thr Ser Arg Thr Thr Ala Thr Ala
2110                2115                2120                2125

 aca ccc agc aag acc cgc acc tcg acc ctg ctg ccc agc agc ccc aca     6614
 Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Ser Pro Thr
                2130                2135                2140

 tcg gcc ccc ata acc acg gtg gtg acc acg ggc tgt gag ccc cag tgt     6662
 Ser Ala Pro Ile Thr Thr Val Val Thr Thr Gly Cys Glu Pro Gln Cys
            2145                2150                2155

 gcc tgg tca gag tgg ctg gac tac agc tac ccc atg ccg ggg ccc tct     6710
 Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser
        2160                2165                2170

 ggc ggg gac ttt gac acc tac tcc aac atc cgt gcg gcc gga ggg gca     6758
 Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala
    2175                2180                2185

 gtc tgt gag cag ccc ctg ggc ctt gag tgc cgt gcc cag gcc cag cct     6806
 Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro
2190                2195                2200                2205

 ggt gtc ccc ctg cgg gag ttg ggc cag gtc gtg gaa tgc agc ctg gac     6854
 Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp
                2210                2215                2220

 ttt ggc ctg gtc tgc agg aac cgt gag cag gtg ggg aag ttc aag atg     6902
 Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met
            2225                2230                2235

 tgc ttc aac tat gaa atc cgt gtg ttc tgc tgc aac tac ggc cac tgc     6950
 Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys
        2240                2245                2250

 ccc agc acc ccg gcc acc agc tct acg gcc acg ccc tcc tca act ccg     6998
 Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro
    2255                2260                2265

 ggg acg acc tgg atc ctc aca aag ctg acc aca aca gcc act acg act     7046
 Gly Thr Thr Trp Ile Leu Thr Lys Leu Thr Thr Thr Ala Thr Thr Thr
2270                2275                2280                2285

 gag tcc act gga tcc acg gcc acc ccg tcc tcc acc cag gga cca cct     7094
 Glu Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Gln Gly Pro Pro
                2290                2295                2300

 gct ggc acc cca cat gtg agc acc acg gcc acg aca ccc aca gtc acc     7142
 Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr
            2305                2310                2315

 agc tcc aaa gcc act ccc ttc tcc agt cca ggg act gca acc gcc ctt     7190
 Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala Thr Ala Leu
        2320                2325                2330

 cca gca ctg aga agc aca gcc acc aca ccc aca gct acc agc ttt aca     7238
 Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr
    2335                2340                2345

 gcc atc ccc tcc tcc tcc ctg ggc acc acc tgg acc cgc cta tca cag     7286
 Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln
2350                2355                2360                2365

 acc acc aca ccc atg gcc acc atg tcc aca gcc aca ccc tcc tcc act     7334
 Thr Thr Thr Pro Met Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr
                2370                2375                2380

 cca gag act gtc cac acc tcc aca gtg ctt acc acc acg gcc acc aca     7382
 Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Thr
            2385                2390                2395

 acc ggg gcc acc ggc tct gtg gcc acc ccc tcc tcc acc cca gga aca     7430
 Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr
        2400                2405                2410

 gct cac act acc aaa gtg ccg act acc aca acc acg ggc ttc aca gtc     7478
 Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Val
    2415                2420                2425

 acc ccc tcc tcc agc cca ggg acg gca cgc acg cct cca gtg tgg atc     7526
 Thr Pro Ser Ser Ser Pro Gly Thr Ala Arg Thr Pro Pro Val Trp Ile
2430                2435                2440                2445

 agc aca acc acc aca ccc aca acc agt ggc tcc acg gtg acc ccc tcc     7574
 Ser Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val Thr Pro Ser
                2450                2455                2460

 tcc atc ccg ggg acc acc cac acc ccc aca gtg ctg acc acc acc aca     7622
 Ser Ile Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr Thr Thr Thr
            2465                2470                2475

 caa cct gtg gcc act ggt tct atg gca aca ccc tcc tct agc aca cag     7670
 Gln Pro Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln
        2480                2485                2490

 acc agt ggt act ccc cca tca ctg atc acc acg gcc act acg atc acg     7718
 Thr Ser Gly Thr Pro Pro Ser Leu Ile Thr Thr Ala Thr Thr Ile Thr
    2495                2500                2505

 gcc acc ggc tcc acc acc aac ccc tcc tca act cca ggg aca aca cct     7766
 Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro
2510                2515                2520                2525

 atc ccc cca gag ctg acc acc acc gcc acc aca cct gca gcc acc agc     7814
 Ile Pro Pro Glu Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser
                2530                2535                2540

 agc aca gtg act ccc tcc tct gcc cta ggg acc acc cac aca ccc cca     7862
 Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro
            2545                2550                2555

 gtg ccg aac acc acg gcc acc aca cac ggg cga tcc ctg tcc ccc agc     7910
 Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro Ser
        2560                2565                2570

 agt ccc cac acg gtg cgc aca gcc tgg act tcg gcc acc tca ggc acc     7958
 Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser Gly Thr
    2575                2580                2585

 ttg ggc acc acc cac atc aca gag cct tcc acg ggg act tcc cac acc     8006
 Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His Thr
2590                2595                2600                2605

 cca gca gca acc acc ggt acc aca acg acc tcg act cca gcc ctg tcc     8054
 Pro Ala Ala Thr Thr Gly Thr Thr Thr Thr Ser Thr Pro Ala Leu Ser
                2610                2615                2620

 agc cct cac cct agc agc agg acc acc gag tca ccc cct tcc cca ggg     8102
 Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly
            2625                2630                2635

 acg acc acc ccg ggc cac acc acg gcc acc tcc agg acc acg gcc acg     8150
 Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr Ala Thr
        2640                2645                2650

 gcc aca ccc agc aag acc cgc acc tcg acc ctg ctg ccc agc cag ccc     8198
 Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Gln Pro
    2655                2660                2665

 aca tcg gcc ccc ata acc acg gtg gtg acc acg ggc tgt gag ccc cag     8246
 Thr Ser Ala Pro Ile Thr Thr Val Val Thr Thr Gly Cys Glu Pro Gln
2670                2675                2680                2685

 tgt gcc tgg tca gag tgg ctg gac tac agc tac ccc atg ccg ggg ccc     8294
 Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro
                2690                2695                2700

 tct ggc ggg gac ttt gac acc tac tcc aac atc cgt gcg gcc gga ggg     8342
 Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly
            2705                2710                2715

 gcc gtc tgt gag cag ccc ctg ggc ctc gag tgc cgt gcc acg gcc cag     8390
 Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Thr Ala Gln
        2720                2725                2730

 cct ggt gtc ccc ctg ggg gag ttg ggc cag gtc gtg gaa tgc agc ctg     8438
 Pro Gly Val Pro Leu Gly Glu Leu Gly Gln Val Val Glu Cys Ser Leu
    2735                2740                2745

 gac ttt ggc ctg gtc tgc agg aac cgt gag cag gtg ggg aag ttc aag     8486
 Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys
2750                2755                2760                2765

 atg tgc ttc aac tat gaa atc cgt gtg ttc tgc tgc aac tac ggc cac     8534
 Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His
                2770                2775                2780

 tgc ccc agc acc ccg gcc acc agc tct acg gcc atg ccc tcc tcc act     8582
 Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Met Pro Ser Ser Thr
            2785                2790                2795

 ccg ggg acg acc tgg atc ctc aca gag ctg acc aca aca gcc act acg     8630
 Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr
        2800                2805                2810

 act gca tcc act gga tcc acg gcc acc ccg tcc tcc acc ccg gga aca     8678
 Thr Ala Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr
    2815                2820                2825

 gct ccc cct ccc aaa gtg ctg acc agc ccg gcc acc aca ccc aca gcc     8726
 Ala Pro Pro Pro Lys Val Leu Thr Ser Pro Ala Thr Thr Pro Thr Ala
2830                2835                2840                2845

 acc agt tcc aaa gcc act tcc tcc tcc agt cca agg act gca acc acc     8774
 Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr
                2850                2855                2860

 ctt cca gtg ctg aca agc aca gcc acc aaa tcc aca gct acc agc gtt     8822
 Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser Val
            2865                2870                2875

 aca ccc atc ccc tcc tcc acc ctt ggg acc acc ggg acc ctc cca gaa     8870
 Thr Pro Ile Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr Leu Pro Glu
        2880                2885                2890

 cag acc acc aca ccc gtg gcc acc atg tcc aca atc cac ccc tcc tcc     8918
 Gln Thr Thr Thr Pro Val Ala Thr Met Ser Thr Ile His Pro Ser Ser
    2895                2900                2905

 act ccg gag acc acc cac acc tcc aca gtg ctg acc acg aag gcc acg     8966
 Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Lys Ala Thr
2910                2915                2920                2925

 aca agg gcc acc agt tcc acg tcc acc ccc tcc tcc act ccg ggg acg     9014
 Thr Arg Ala Thr Ser Ser Thr Ser Thr Pro Ser Ser Thr Pro Gly Thr
                2930                2935                2940

 acc tgg atc ctc aca gag ctg acc aca gca gcc act aca act gca ggc     9062
 Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr Thr Thr Ala Gly
            2945                2950                2955

 act ggc ccc acg gcc acc ccg tcc tcc acc cca ggg acc acc tgg atc     9110
 Thr Gly Pro Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile
        2960                2965                2970

 ctc aca gag ctg acc aca aca gcc act acg act gcg tcc act gga tcc     9158
 Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ser Thr Gly Ser
    2975                2980                2985

 acg gcc acc ctg tcc tcc acc cca ggg acc acc tgg atc ctc aca gag     9206
 Thr Ala Thr Leu Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu
2990                2995                3000                3005

 ccg agc act aca gcc acc gtg acg gcc cca ccg gga tcc acg gcc acc     9254
 Pro Ser Thr Thr Ala Thr Val Thr Ala Pro Pro Gly Ser Thr Ala Thr
                3010                3015                3020

 gcc tcc tcc acc cag gca act gct ggc acc cca cat gtg agc acc acg     9302
 Ala Ser Ser Thr Gln Ala Thr Ala Gly Thr Pro His Val Ser Thr Thr
            3025                3030                3035

 gcc acg aca ccc aca gtc acc agc tcc aaa gcc act ccc tcc tcc agt     9350
 Ala Thr Thr Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Ser Ser Ser
        3040                3045                3050

 cca ggg act gca act gcc ctt cca gca ctg aga agc aca gcc acc aca     9398
 Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr
    3055                3060                3065

 ccc aca gct acc agc ttt aca gcc atc ccc tcc tcc tcc ctg ggc acc     9446
 Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr
3070                3075                3080                3085

 acc tgg acc cgc cta tca cag acc acc aca ccc acg gcc acc atg tcc     9494
 Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser
                3090                3095                3100

 aca gcc aca ccc tcc tcc act cca gag act gtc cac acc tcc aca gtg     9542
 Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His Thr Ser Thr Val
            3105                3110                3115

 ctt acc acc acg gcc acc aca acc ggg gcc acc ggc tct gtg gcc acc     9590
 Leu Thr Thr Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr
        3120                3125                3130

 ccc tcc tcc acc cca gga aca gct cac act acc aaa gtg ccg act acc     9638
 Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr
    3135                3140                3145

 aca acc acg ggc ttc aca gcc acc ccc tcc tcc agc cca ggg acg gca     9686
 Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala
3150                3155                3160                3165

 ctc acg cct cca gtg tgg atc agc aca acc acc aca ccc aca acc acc     9734
 Leu Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Thr
                3170                3175                3180

 aca ccc aca acc agt ggc tcc acg gtg acc ccc tcc tcc atc cca ggg     9782
 Thr Pro Thr Thr Ser Gly Ser Thr Val Thr Pro Ser Ser Ile Pro Gly
            3185                3190                3195

 acc acc cac acc gcc aga gtg ctg acc acc acc acc aca act gtg gcc     9830
 Thr Thr His Thr Ala Arg Val Leu Thr Thr Thr Thr Thr Thr Val Ala
        3200                3205                3210

 act ggt tct atg gca aca ccc tcc tct agc aca cag acc agt ggt act     9878
 Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr
    3215                3220                3225

 ccc cca tca ctg acc acc acg gcc act acg atc acg gcc acc ggc tcc     9926
 Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser
3230                3235                3240                3245

 acc acc aac ccc tcc tca act cca ggg aca aca ccc atc ccc cca gtg     9974
 Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro Val
                3250                3255                3260

 ctg acc agc atg gcc acc aca ccc gca gcc acc agc tcc aaa gcc act    10022
 Leu Thr Ser Met Ala Thr Thr Pro Ala Ala Thr Ser Ser Lys Ala Thr
            3265                3270                3275

 tcc tcc tcc agt cca agg act gca acc acc ctt cca gtg ctg aca agc    10070
 Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro Val Leu Thr Ser
        3280                3285                3290

 aca gcc aca aaa tcc aca gct acc agc ttt aca ccc atc ccc tcc tcc    10118
 Thr Ala Thr Lys Ser Thr Ala Thr Ser Phe Thr Pro Ile Pro Ser Ser
    3295                3300                3305

 acc ctg tgg acc acg tgg acc gtc cca gca cag acc acc aca ccc atg    10166
 Thr Leu Trp Thr Thr Trp Thr Val Pro Ala Gln Thr Thr Thr Pro Met
3310                3315                3320                3325

 tcc acc atg tcc aca atc cac acc tcc tct act cca gag acc acc cac    10214
 Ser Thr Met Ser Thr Ile His Thr Ser Ser Thr Pro Glu Thr Thr His
                3330                3335                3340

 acc tcc aca gtg ctg acc acc aca gcc acc atg aca agg gcc acc aat    10262
 Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Met Thr Arg Ala Thr Asn
            3345                3350                3355

 tcc acg gcc aca ccc tcc tcc act ctg ggg acg acc cgg atc ctc act    10310
 Ser Thr Ala Thr Pro Ser Ser Thr Leu Gly Thr Thr Arg Ile Leu Thr
        3360                3365                3370

 gag ctg acc aca aca gcc act aca act gca gcc act gga tcc acg gcc    10358
 Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ala Thr Gly Ser Thr Ala
    3375                3380                3385

 acc ctg tcc tcc acc cca ggg acc acc tgg atc ctc aca gag ccg agc    10406
 Thr Leu Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser
3390                3395                3400                3405

 act ata gcc acc gtg atg gtg ccc acc ggt tcc acg gcc acc acc tcc    10454
 Thr Ile Ala Thr Val Met Val Pro Thr Gly Ser Thr Ala Thr Thr Ser
                3410                3415                3420

 tcc act ctg gga aca gct cac acc ccc aaa gtg gtg acc gcc atg gcc    10502
 Ser Thr Leu Gly Thr Ala His Thr Pro Lys Val Val Thr Ala Met Ala
            3425                3430                3435

 act atg ccc aca gcc act gcc tcc acg gtt ccc agc tcg tcc acc gtg    10550
 Thr Met Pro Thr Ala Thr Ala Ser Thr Val Pro Ser Ser Ser Thr Val
        3440                3445                3450

 ggg acc acc cgc acc cct gca gtg ctc ccc agc agc ctg cca acc ttc    10598
 Gly Thr Thr Arg Thr Pro Ala Val Leu Pro Ser Ser Leu Pro Thr Phe
    3455                3460                3465

 agc gtg tcc act gtg tcc tcc tca gtc ctc acc acc ctg aga ccc act    10646
 Ser Val Ser Thr Val Ser Ser Ser Val Leu Thr Thr Leu Arg Pro Thr
3470                3475                3480                3485

 ggc ttc ccc agc tcc cac ttc tct act ccc tgc ttc tgc agg gca ttt    10694
 Gly Phe Pro Ser Ser His Phe Ser Thr Pro Cys Phe Cys Arg Ala Phe
                3490                3495                3500

 gga cag ttt ttc tcg ccc ggg gaa gtc atc tac aat aag acc gac cga    10742
 Gly Gln Phe Phe Ser Pro Gly Glu Val Ile Tyr Asn Lys Thr Asp Arg
            3505                3510                3515

 gcc ggc tgc cat ttc tac gca gtg tgc aat cag cac tgt gac att gac    10790
 Ala Gly Cys His Phe Tyr Ala Val Cys Asn Gln His Cys Asp Ile Asp
        3520                3525                3530

 cgc ttc cag ggc gcc tgt ccc acc tcc cca ccg cca gtg tcc tcc gcc    10838
 Arg Phe Gln Gly Ala Cys Pro Thr Ser Pro Pro Pro Val Ser Ser Ala
    3535                3540                3545

 ccg ctg tcc tcg ccc tcc cct gcc cct ggc tgt gac aat gcc atc cct    10886
 Pro Leu Ser Ser Pro Ser Pro Ala Pro Gly Cys Asp Asn Ala Ile Pro
3550                3555                3560                3565

 ctc cgg cag gtg aat gag acc tgg acc ctg gag aac tgc acg gtg gcc    10934
 Leu Arg Gln Val Asn Glu Thr Trp Thr Leu Glu Asn Cys Thr Val Ala
                3570                3575                3580

 agg tgc gtg ggt gac aac cgt gtc gtc ctg ctg gac cca aag cct gtg    10982
 Arg Cys Val Gly Asp Asn Arg Val Val Leu Leu Asp Pro Lys Pro Val
            3585                3590                3595

 gcc aac gtc acc tgc gtg aac aag cac ctg ccc atc aaa gtg tcg gac    11030
 Ala Asn Val Thr Cys Val Asn Lys His Leu Pro Ile Lys Val Ser Asp
        3600                3605                3610

 ccg agc cag ccc tgt gac ttc cac tat gag tgc gag tgc atc tgc agc    11078
 Pro Ser Gln Pro Cys Asp Phe His Tyr Glu Cys Glu Cys Ile Cys Ser
    3615                3620                3625

 atg tgg ggc ggc tcc cac tat tcc acc ttt gac ggc acc tct tac acc    11126
 Met Trp Gly Gly Ser His Tyr Ser Thr Phe Asp Gly Thr Ser Tyr Thr
3630                3635                3640                3645

 ttc cgg ggc aac tgc acc tat gtc ctc atg aga gag atc cat gca cgc    11174
 Phe Arg Gly Asn Cys Thr Tyr Val Leu Met Arg Glu Ile His Ala Arg
                3650                3655                3660

 ttt ggg aat ctc agc ctc tac ctg gac aac cac tac tgc acg gcc tct    11222
 Phe Gly Asn Leu Ser Leu Tyr Leu Asp Asn His Tyr Cys Thr Ala Ser
            3665                3670                3675

 gcc act gcc gct gcc gcc cgc tgc ccc gcg gcc ctc agc atc cac tac    11270
 Ala Thr Ala Ala Ala Ala Arg Cys Pro Ala Ala Leu Ser Ile His Tyr
        3680                3685                3690

 aag tcc atg gat atc gtc ctc act gtc acc atg gtg cat ggg aag gag    11318
 Lys Ser Met Asp Ile Val Leu Thr Val Thr Met Val His Gly Lys Glu
    3695                3700                3705

 gag ggc ctg atc ctg ttt gac caa att ccg gtg agc agc ggt ttc agc    11366
 Glu Gly Leu Ile Leu Phe Asp Gln Ile Pro Val Ser Ser Gly Phe Ser
3710                3715                3720                3725

 aag aac ggc gtg ctt gtg cct gtg ctg ggg acc acc acc atg cgt gtg    11414
 Lys Asn Gly Val Leu Val Pro Val Leu Gly Thr Thr Thr Met Arg Val
                3730                3735                3740

 gac att cct gcc ctg ggc gtg agc gtc acc ttc aat ggc caa gtc ttc    11462
 Asp Ile Pro Ala Leu Gly Val Ser Val Thr Phe Asn Gly Gln Val Phe
            3745                3750                3755

 cag gcc cgg ctg ccc tac agc ctc ttc cac aac aac acc gag ggc cag    11510
 Gln Ala Arg Leu Pro Tyr Ser Leu Phe His Asn Asn Thr Glu Gly Gln
        3760                3765                3770

 tgc ggc acc tgc acc aac aac cag agg gac gac tgt ctc cag cgg gac    11558
 Cys Gly Thr Cys Thr Asn Asn Gln Arg Asp Asp Cys Leu Gln Arg Asp
    3775                3780                3785

 gga acc act gcc gcc agt tgc aag gac atg gcc aag acg tgg ctg gtc    11606
 Gly Thr Thr Ala Ala Ser Cys Lys Asp Met Ala Lys Thr Trp Leu Val
3790                3795                3800                3805

 ccc gac agc aga aag gat ggc tgc tgg gcc ccg act ggc aca ccc ccc    11654
 Pro Asp Ser Arg Lys Asp Gly Cys Trp Ala Pro Thr Gly Thr Pro Pro
                3810                3815                3820

 act gcc agc ccc gca gcc ccg gtg tct agc aca ccc acc ccc acc cca    11702
 Thr Ala Ser Pro Ala Ala Pro Val Ser Ser Thr Pro Thr Pro Thr Pro
            3825                3830                3835

 tgc cca cca cag ccg ctc tgt gat ctg atg ctg agc cag gtc ttt gct    11750
 Cys Pro Pro Gln Pro Leu Cys Asp Leu Met Leu Ser Gln Val Phe Ala
        3840                3845                3850

 gag tgc cac aac ctt gtg ccc ccg ggc cca ttc ttc aac gcc tgc atc    11798
 Glu Cys His Asn Leu Val Pro Pro Gly Pro Phe Phe Asn Ala Cys Ile
    3855                3860                3865

 agc gac cac tgc agg ggc cgc ctt gag gtg ccc tgc cag agc ctg gag    11846
 Ser Asp His Cys Arg Gly Arg Leu Glu Val Pro Cys Gln Ser Leu Glu
3870                3875                3880                3885

 gct tac gca gag ctc tgc cgc gcc cgg gga gtg tgc agt gac tgg cga    11894
 Ala Tyr Ala Glu Leu Cys Arg Ala Arg Gly Val Cys Ser Asp Trp Arg
                3890                3895                3900

 ggt gca act ggt ggc ctg tgc gac ctc acc tgc cca ccc acc aaa gtg    11942
 Gly Ala Thr Gly Gly Leu Cys Asp Leu Thr Cys Pro Pro Thr Lys Val
            3905                3910                3915

 tac aag cca tgc ggc ccc ata cag cct gcc acc tgc aac tct agg aac    11990
 Tyr Lys Pro Cys Gly Pro Ile Gln Pro Ala Thr Cys Asn Ser Arg Asn
        3920                3925                3930

 cag agc cca cag ctg gag ggg atg gcg gag ggc tgc ttc tgc cct gag    12038
 Gln Ser Pro Gln Leu Glu Gly Met Ala Glu Gly Cys Phe Cys Pro Glu
    3935                3940                3945

 gac cag atc ctc ttc aac gca cac atg ggc atc tgc gtg cag gcc tgc    12086
 Asp Gln Ile Leu Phe Asn Ala His Met Gly Ile Cys Val Gln Ala Cys
3950                3955                3960                3965

 ccc tgc gtg gga ccc gat ggg ttt cct aaa ttt ccc ggg gag cgg tgg    12134
 Pro Cys Val Gly Pro Asp Gly Phe Pro Lys Phe Pro Gly Glu Arg Trp
                3970                3975                3980

 gtc agc aac tgc cag tcc tgc gtg tgt gac gag ggt tca gtg tcg gtg    12182
 Val Ser Asn Cys Gln Ser Cys Val Cys Asp Glu Gly Ser Val Ser Val
            3985                3990                3995

 cag tgc aag ccc ctg ccc tgt gac gcc cag ggt cag ccc ccg ccg tgc    12230
 Gln Cys Lys Pro Leu Pro Cys Asp Ala Gln Gly Gln Pro Pro Pro Cys
        4000                4005                4010

 aac cgt ccc ggc ttc gta acc gtg acc agg ccc cgg gcc gag aac ccc    12278
 Asn Arg Pro Gly Phe Val Thr Val Thr Arg Pro Arg Ala Glu Asn Pro
    4015                4020                4025

 tgc tgc ccc gag acg gtg tgc gtg tgc aac aca acc acc tgc ccc cag    12326
 Cys Cys Pro Glu Thr Val Cys Val Cys Asn Thr Thr Thr Cys Pro Gln
4030                4035                4040                4045

 agc ctg cct gtg tgc ccg cca ggg cag gag tcc atc tgc acc cag gag    12374
 Ser Leu Pro Val Cys Pro Pro Gly Gln Glu Ser Ile Cys Thr Gln Glu
                4050                4055                4060

 gag ggc gac tgc tgt ccc acc ttc cgc tgc aga cct cag ctg tgt tcg    12422
 Glu Gly Asp Cys Cys Pro Thr Phe Arg Cys Arg Pro Gln Leu Cys Ser
            4065                4070                4075

 tac aat ggc acc ttc tac ggg gtt ggt gca acc ttc cca ggc gcc ctt    12470
 Tyr Asn Gly Thr Phe Tyr Gly Val Gly Ala Thr Phe Pro Gly Ala Leu
        4080                4085                4090

 ccc tgc cac atg tgt acc tgc ctc tct ggg gac acc cag gac cca acg    12518
 Pro Cys His Met Cys Thr Cys Leu Ser Gly Asp Thr Gln Asp Pro Thr
    4095                4100                4105

 gtg caa tgt cag gag gat gcc tgc aac aat act acc tgt ccc cag ggc    12566
 Val Gln Cys Gln Glu Asp Ala Cys Asn Asn Thr Thr Cys Pro Gln Gly
4110                4115                4120                4125

 ttt gag tac aag aga gtg gcc ggg cag tgc tgt ggg gag tgc gtc cag    12614
 Phe Glu Tyr Lys Arg Val Ala Gly Gln Cys Cys Gly Glu Cys Val Gln
                4130                4135                4140

 acc gcc tgc ctc acg ccc gat ggc cag cca gtc cag ctg aat gaa acc    12662
 Thr Ala Cys Leu Thr Pro Asp Gly Gln Pro Val Gln Leu Asn Glu Thr
            4145                4150                4155

 tgg gtc aac agc cat gtg gac aac tgc acc gtg tac ctc tgt gag gct    12710
 Trp Val Asn Ser His Val Asp Asn Cys Thr Val Tyr Leu Cys Glu Ala
        4160                4165                4170

 gag ggt gga gtc cat ttg ctg acc cca cag cct gca tcc tgc cca gat    12758
 Glu Gly Gly Val His Leu Leu Thr Pro Gln Pro Ala Ser Cys Pro Asp
    4175                4180                4185

 gtg tcc agc tgc agg ggg agc ctc agg aaa acc ggc tgc tgc tac tcc    12806
 Val Ser Ser Cys Arg Gly Ser Leu Arg Lys Thr Gly Cys Cys Tyr Ser
4190                4195                4200                4205

 tgt gag gag gac tcc tgt caa gtc cgc atc aac acg acc atc ctg tgg    12854
 Cys Glu Glu Asp Ser Cys Gln Val Arg Ile Asn Thr Thr Ile Leu Trp
                4210                4215                4220

 cac cag ggc tgc gag acc gag gtc aac atc acc ttc tgc gag ggc tcc    12902
 His Gln Gly Cys Glu Thr Glu Val Asn Ile Thr Phe Cys Glu Gly Ser
            4225                4230                4235

 tgc ccc gga gcg tcc aag tac tca gca gag gcc cag gcc atg cag cac    12950
 Cys Pro Gly Ala Ser Lys Tyr Ser Ala Glu Ala Gln Ala Met Gln His
        4240                4245                4250

 cag tgc acc tgc tgc cag gag agg cgg gtc cac gag gag acg gtg ccc    12998
 Gln Cys Thr Cys Cys Gln Glu Arg Arg Val His Glu Glu Thr Val Pro
    4255                4260                4265

 ttg cac tgt cct aac ggc tca gcc atc ctg cac acc tac acc cac gtg    13046
 Leu His Cys Pro Asn Gly Ser Ala Ile Leu His Thr Tyr Thr His Val
4270                4275                4280                4285

 gat gag tgt ggc tgc acg ccc ttc tgt gtc cct gcg ccc atg gct ccc    13094
 Asp Glu Cys Gly Cys Thr Pro Phe Cys Val Pro Ala Pro Met Ala Pro
                4290                4295                4300

 cca cac acc cgt ggc ttc ccg gcc cag gag gcc act gct gtc tga gaa    13142
 Pro His Thr Arg Gly Phe Pro Ala Gln Glu Ala Thr Ala Val 
            4305                4310                4315

 cgttctgcct ccatccccat gctctgtcca cctggagcca ggatgtgcat tgtctgatca  13202

 tgaaaacctt gggcctcctc tgcggagccc cccggcctgt gtgtggcacc ccgcgctccg  13262

 tgctcctgct gcccaccccg tgggtgaaac cggccccaga agggtgaggg gccagcagga  13322

 ccctttcggg agggcgccac tcaggagtcc taccctggga gagcctgtgg cccaccttgg  13382

 ccttgcccct ccctgatgtc actgggacgc cctggaacaa actaagcatg tgcgggccta  13442

 tgtgtccctg ccacggccgg agcgcccgcg cagcacggat tccagctggc cacgtccggc  13502

 cgctggggca gacaggctgg tccaggcaag gccagctgct gccaggaagc tgcgacaggc  13562

 aagcggccgc ctgtccatgc ctgctgcagg gtaactcagg gctgaggtcg caacggccag  13622

 gtcagagagg ggtcagcatc ccaaagcccc ctctgctcaa cccagcccag ttttgcaaat  13682

 aaaccctgag cattgagtaa aaaaaaaaaa aaa                               13715




      <210> 366
      <211> 3861
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(2505)

      <400> 366
 taagcttgcg gccgctgggc ctgagtgtcg ccttcgccgc catggacgcc accgggcgct     60

 gacagacct    atg gag agt cag ggt gtg cct ccc ggg cct tat cgg gcc     108
              Met Glu Ser Gln Gly Val Pro Pro Gly Pro Tyr Arg Ala
                1               5                  10

 acc aag ctg tgg aat gaa gtt acc aca tct ttt cga gca gga atg cct      156
 Thr Lys Leu Trp Asn Glu Val Thr Thr Ser Phe Arg Ala Gly Met Pro
      15                  20                  25

 cta aga aaa cac aga caa cac ttt aaa aaa tat ggc aat tgt ttc aca      204
 Leu Arg Lys His Arg Gln His Phe Lys Lys Tyr Gly Asn Cys Phe Thr
  30                  35                  40                  45

 gca gga gaa gca gtg gat tgg ctt tat gac cta tta aga aat aat agc      252
 Ala Gly Glu Ala Val Asp Trp Leu Tyr Asp Leu Leu Arg Asn Asn Ser
                  50                  55                  60

 aat ttt ggt cct gaa gtt aca agg caa cag act atc caa ctg ttg agg      300
 Asn Phe Gly Pro Glu Val Thr Arg Gln Gln Thr Ile Gln Leu Leu Arg
              65                  70                  75

 aaa ttt ctt aag aat cat gta att gaa gat atc aaa ggg agg tgg gga      348
 Lys Phe Leu Lys Asn His Val Ile Glu Asp Ile Lys Gly Arg Trp Gly
          80                  85                  90

 tca gaa aat gtt gat gat aac aac cag ctc ttc aga ttt cct gca act      396
 Ser Glu Asn Val Asp Asp Asn Asn Gln Leu Phe Arg Phe Pro Ala Thr
      95                 100                 105

 tcg cca ctt aaa act cta cca cga agg tat cca gaa ttg aga aaa aac      444
 Ser Pro Leu Lys Thr Leu Pro Arg Arg Tyr Pro Glu Leu Arg Lys Asn
 110                 115                 120                 125

 aac ata gag aac ttt tcc aaa gat aaa gat agc att ttt aaa tta cga      492
 Asn Ile Glu Asn Phe Ser Lys Asp Lys Asp Ser Ile Phe Lys Leu Arg
                 130                 135                 140

 aac tta tct cgt aga act cct aaa agg cat gga tta cat tta tct cag      540
 Asn Leu Ser Arg Arg Thr Pro Lys Arg His Gly Leu His Leu Ser Gln
             145                 150                 155

 gaa aat ggc gag aaa ata aag cat gaa ata atc aat gaa gat caa gaa      588
 Glu Asn Gly Glu Lys Ile Lys His Glu Ile Ile Asn Glu Asp Gln Glu
         160                 165                 170

 aat gca att gat aat aga gaa cta agc cag gaa gat gtt gaa gaa gtt      636
 Asn Ala Ile Asp Asn Arg Glu Leu Ser Gln Glu Asp Val Glu Glu Val
     175                 180                 185

 tgg aga tat gtt att ctg atc tac ctg caa acc att tta ggt gtg cca      684
 Trp Arg Tyr Val Ile Leu Ile Tyr Leu Gln Thr Ile Leu Gly Val Pro
 190                 195                 200                 205

 tcc cta gaa gaa gtc ata aat cca aaa caa gta att ccc caa tat ata      732
 Ser Leu Glu Glu Val Ile Asn Pro Lys Gln Val Ile Pro Gln Tyr Ile
                 210                 215                 220

 atg tac aac atg gcc aat aca agt aaa cgt gga gta gtt ata cta caa      780
 Met Tyr Asn Met Ala Asn Thr Ser Lys Arg Gly Val Val Ile Leu Gln
             225                 230                 235

 aac aaa tca gat gac ctc cct cac tgg gta tta tct gcc atg aag tgc      828
 Asn Lys Ser Asp Asp Leu Pro His Trp Val Leu Ser Ala Met Lys Cys
         240                 245                 250

 cta gca aat tgg cca aga agc aat gat atg aat aat cca act tat gtt      876
 Leu Ala Asn Trp Pro Arg Ser Asn Asp Met Asn Asn Pro Thr Tyr Val
     255                 260                 265

 gga ttt gaa cga gat gta ttc aga aca atc gca gat tat ttt cta gat      924
 Gly Phe Glu Arg Asp Val Phe Arg Thr Ile Ala Asp Tyr Phe Leu Asp
 270                 275                 280                 285

 ctc cct gaa cct cta ctt act ttt gaa tat tac gaa tta ttt gta aac      972
 Leu Pro Glu Pro Leu Leu Thr Phe Glu Tyr Tyr Glu Leu Phe Val Asn
                 290                 295                 300

 att ttg gtt gtt tgt ggc tac atc aca gtt tca gat aga tcc agt ggg     1020
 Ile Leu Val Val Cys Gly Tyr Ile Thr Val Ser Asp Arg Ser Ser Gly
             305                 310                 315

 ata cat aaa att caa gat gat cca cag tct tca aaa ttc ctt cac tta     1068
 Ile His Lys Ile Gln Asp Asp Pro Gln Ser Ser Lys Phe Leu His Leu
         320                 325                 330

 aac aat ttg aat tcc ttc aaa tca act gag tgc ctt ctt ctc agt ctg     1116
 Asn Asn Leu Asn Ser Phe Lys Ser Thr Glu Cys Leu Leu Leu Ser Leu
     335                 340                 345

 ctt cat aga gaa aaa aaa aaa gaa gaa tca gat tct act gag aga cta     1164
 Leu His Arg Glu Lys Lys Lys Glu Glu Ser Asp Ser Thr Glu Arg Leu
 350                 355                 360                 365

 cag ata agc aat cca gga ttt caa gaa aga tgt gct aag aaa atg cag     1212
 Gln Ile Ser Asn Pro Gly Phe Gln Glu Arg Cys Ala Lys Lys Met Gln
                 370                 375                 380

 cta gtt aat tta aga aac aga aga gtg agt gct aat gac ata atg gga     1260
 Leu Val Asn Leu Arg Asn Arg Arg Val Ser Ala Asn Asp Ile Met Gly
             385                 390                 395

 gga agt tgt cat aat tta ata ggg tta agt aat atg cat gat cta tcc     1308
 Gly Ser Cys His Asn Leu Ile Gly Leu Ser Asn Met His Asp Leu Ser
         400                 405                 410

 tct aac agc aaa cca agg tgc tgt tct ttg gaa gga att gta gat gtg     1356
 Ser Asn Ser Lys Pro Arg Cys Cys Ser Leu Glu Gly Ile Val Asp Val
     415                 420                 425

 cca ggg aat tca agt aaa gag gca tcc agt gtc ttt cat caa tct ttt     1404
 Pro Gly Asn Ser Ser Lys Glu Ala Ser Ser Val Phe His Gln Ser Phe
 430                 435                 440                 445

 ccg aac ata gaa gga caa aat aat aaa ctg ttt tta gag tct aag ccc     1452
 Pro Asn Ile Glu Gly Gln Asn Asn Lys Leu Phe Leu Glu Ser Lys Pro
                 450                 455                 460

 aaa cag gaa ttc ctg ttg aat ctt cat tca gag gaa aat att caa aag     1500
 Lys Gln Glu Phe Leu Leu Asn Leu His Ser Glu Glu Asn Ile Gln Lys
             465                 470                 475

 cca ttc agt gct ggt ttt aag aga acc tct act ttg act gtt caa gac     1548
 Pro Phe Ser Ala Gly Phe Lys Arg Thr Ser Thr Leu Thr Val Gln Asp
         480                 485                 490

 caa gag gag ttg tgt aat ggg aaa tgc aag tca aaa cag ctt tgt agg     1596
 Gln Glu Glu Leu Cys Asn Gly Lys Cys Lys Ser Lys Gln Leu Cys Arg
     495                 500                 505

 tct cag agt ttg ctt tta aga agt agt aca aga agg aat agt tat atc     1644
 Ser Gln Ser Leu Leu Leu Arg Ser Ser Thr Arg Arg Asn Ser Tyr Ile
 510                 515                 520                 525

 aat aca cca gtg gct gaa att atc atg aaa cca aat gtt gga caa ggc     1692
 Asn Thr Pro Val Ala Glu Ile Ile Met Lys Pro Asn Val Gly Gln Gly
                 530                 535                 540

 agc aca agt gtg caa aca gct atg gaa agt gaa ctc gga gag tct agt     1740
 Ser Thr Ser Val Gln Thr Ala Met Glu Ser Glu Leu Gly Glu Ser Ser
             545                 550                 555

 gcc aca atc aat aaa aga ctc tgc aaa agt aca ata gaa ctt tca gaa     1788
 Ala Thr Ile Asn Lys Arg Leu Cys Lys Ser Thr Ile Glu Leu Ser Glu
         560                 565                 570

 aat tct tta ctt cca gct tct tct atg ttg act ggc aca caa agc ttg     1836
 Asn Ser Leu Leu Pro Ala Ser Ser Met Leu Thr Gly Thr Gln Ser Leu
     575                 580                 585

 ctg caa cct cat tta gag agg gtt gcc atc gat gct cta cag tta tgt     1884
 Leu Gln Pro His Leu Glu Arg Val Ala Ile Asp Ala Leu Gln Leu Cys
 590                 595                 600                 605

 tgt ttg tta ctt ccc cca cca aat cgt aga aag ctt caa ctt tta atg     1932
 Cys Leu Leu Leu Pro Pro Pro Asn Arg Arg Lys Leu Gln Leu Leu Met
                 610                 615                 620

 cgt atg att tcc cga atg agt caa aat gtt gat atg ccc aaa ctt cat     1980
 Arg Met Ile Ser Arg Met Ser Gln Asn Val Asp Met Pro Lys Leu His
             625                 630                 635

 gat gca atg ggt acg agg tca ctg atg ata cat acc ttt tct cga tgt     2028
 Asp Ala Met Gly Thr Arg Ser Leu Met Ile His Thr Phe Ser Arg Cys
         640                 645                 650

 gtg tta tgc tgt gct gaa gaa gtg gat ctt gat gag ctt ctt gct gga     2076
 Val Leu Cys Cys Ala Glu Glu Val Asp Leu Asp Glu Leu Leu Ala Gly
     655                 660                 665

 aga tta gtt tct ttc tta atg gat cat cat cag gaa att ctt caa gta     2124
 Arg Leu Val Ser Phe Leu Met Asp His His Gln Glu Ile Leu Gln Val
 670                 675                 680                 685

 ccc tct tac tta cag act gca gtg gaa aaa cat ctt gac tac tta aaa     2172
 Pro Ser Tyr Leu Gln Thr Ala Val Glu Lys His Leu Asp Tyr Leu Lys
                 690                 695                 700

 aag gga cat att gaa aat cct gga gat gga cta ttt gct cct ttg cca     2220
 Lys Gly His Ile Glu Asn Pro Gly Asp Gly Leu Phe Ala Pro Leu Pro
             705                 710                 715

 act tac tca tac tgt aag cag att agt gct cag gag ttt gat gag caa     2268
 Thr Tyr Ser Tyr Cys Lys Gln Ile Ser Ala Gln Glu Phe Asp Glu Gln
         720                 725                 730

 aaa gtt tct acc tct caa gct gca att gca gaa ctt tta gaa aat att     2316
 Lys Val Ser Thr Ser Gln Ala Ala Ile Ala Glu Leu Leu Glu Asn Ile
     735                 740                 745

 att aaa aac agg agt tta cct cta aag gag aaa aga aaa aaa cta aaa     2364
 Ile Lys Asn Arg Ser Leu Pro Leu Lys Glu Lys Arg Lys Lys Leu Lys
 750                 755                 760                 765

 cag ttt cag aag gaa tat cct ttg ata tat cag aaa aga ttt cca acc     2412
 Gln Phe Gln Lys Glu Tyr Pro Leu Ile Tyr Gln Lys Arg Phe Pro Thr
                 770                 775                 780

 acg gag agt gaa gca gca ctt ttt ggt gac aaa cct aca atc aag caa     2460
 Thr Glu Ser Glu Ala Ala Leu Phe Gly Asp Lys Pro Thr Ile Lys Gln
             785                 790                 795

 cca atg ctg att tta aga aaa cca aag ttc cgt agt cta aga taa cta     2508
 Pro Met Leu Ile Leu Arg Lys Pro Lys Phe Arg Ser Leu Arg 
         800                 805                 810

 actgaattaa aaattatgta atacttgtgg aactttgata aatgaagcca tatctgagaa   2568

 tgtagctact caaaaggaag tctgtcatta ataaggtatt tctaaataaa cacattatgt   2628

 aaggaagtgc caaaatagtt atcaatgtga gactcttagg aaactaacta gatctcaatt   2688

 gagagcacat aacaatagat gataccaaat actttttgtt tttaacacag ctatccagta   2748

 aggctatcat gatgtgtgct aaaattttat ttacttgaat tttgaaaact gagctgtgtt   2808

 agggattaaa ctataattct gttcttaaaa gaaaatttat ctgcaaatgt gcaagttctg   2868

 agatattagc taatgaatta gttgtttggg gttacttctt tgtttctaag tataagaatg   2928

 tgaagaatat ttgaaaactc aatgaaataa ttctcagctg ccaaatgttg cactctttta   2988

 tatattcttt ttccactttt gatctattta tatatatgta tgtgttttta aaatatgtgt   3048

 atattttatc agatttggtt ttgccttaaa tattatcccc aattgcttca gtcattcatt   3108

 tgttcagtat atatattttg aattctagtt ttcataatct attagaagat ggggatataa   3168

 aagaagtata aggcaatcat atattcattc aaaagatatt tatttagcaa ctgctatgtg   3228

 cctttcgttg ttccagatat gcagagacaa tgataaataa aacatataat ctcttccata   3288

 aggtatttat tttttaatca agggagatac acctatcaga tgtttaaaat aacaacacta   3348

 cccactgaaa tcagggcata tagaatcatt cagctaaaga gtgacttcta tgatgatgga   3408

 acaggtctct aagctagtgg ttttcaaact ggtacacatt agactcaccc gaggaatttt   3468

 aaaacagcct atatgcccag ggcctaactt acactaatta aatctgaatt ttggggatgt   3528

 tgtataggga ttagtatttt ttttaatcta ggtgattcca atattcagcc aactgtgaga   3588

 atcaatggcc taaatgcttt ttataaacat ttttataagt gtcaagataa tggcacattg   3648

 actttatttt ttcattggaa gaaaatgcct gccaagtata aatgactctc atcttaaaac   3708

 aaggttcttc aggtttctgc ttgattgact tggtacaaac ttgaagcaag ttgccttcta   3768

 atttttactc caagattgtt tcatatctat tccttaagtg taaagaaata tataatgcat   3828

 ggtttgtaat aaaatcttaa tgtttaatga ctg                                3861




      <210> 367
      <211> 1749
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (390)..(1742)

      <400> 367
 tctgcagcca cgagaagcaa agttgacatt tctggatcac tctccccaga cgcgtcactt     60

 gcccacaagc gggacacggc agtctcgctg agccagctgt gcagagggac agatggaaga    120

 aagctagaga tgctgcttcg tgggcgctga agttgcagaa cttgggctgg ttttctttct    180

 tcccatcccc cctcctcctg acaaaccaca tcttgactca gatggtcgaa agaaaaactc    240

 tttcagttat ttgatatttg ggaaccctcc aggagaccat aacttatttt tgagggaggc    300

 tccttctctc cctttgctgg gaacacacac acacacacac acacacacac acacacacac    360

 acacacacac acacacacag ctgtacacc  atg gtg gtt cag gct gca gtg gct     413
                                  Met Val Val Gln Ala Ala Val Ala
                                    1               5

 ccg aat aga tcc caa aga ctt tta ctg aaa att cct tat gga tct ctg      461
 Pro Asn Arg Ser Gln Arg Leu Leu Leu Lys Ile Pro Tyr Gly Ser Leu
      10                  15                  20

 aga agg cgc agc gtt gaa agg atg acg gag ggc cgc cga tgt caa gta      509
 Arg Arg Arg Ser Val Glu Arg Met Thr Glu Gly Arg Arg Cys Gln Val
  25                  30                  35                  40

 cat ctt ctt gat gac agg aag ctg gaa ctc cta gta cag ccc aag ctg      557
 His Leu Leu Asp Asp Arg Lys Leu Glu Leu Leu Val Gln Pro Lys Leu
                  45                  50                  55

 ttg gcc aag gag ctt ctt gac ctt gtg gct tct cac ttc aat ctg aag      605
 Leu Ala Lys Glu Leu Leu Asp Leu Val Ala Ser His Phe Asn Leu Lys
              60                  65                  70

 gaa aag gag tac ttt gga ata gca ttc aca gat gaa acg gga cac tta      653
 Glu Lys Glu Tyr Phe Gly Ile Ala Phe Thr Asp Glu Thr Gly His Leu
          75                  80                  85

 aac tgg ctt cag cta gat cga aga gta ttg gaa cat gac ttc cct aaa      701
 Asn Trp Leu Gln Leu Asp Arg Arg Val Leu Glu His Asp Phe Pro Lys
      90                  95                 100

 aag tca gga ccc gtg gtt tta tac ttt tgt gtc agg ttc tat ata gaa      749
 Lys Ser Gly Pro Val Val Leu Tyr Phe Cys Val Arg Phe Tyr Ile Glu
 105                 110                 115                 120

 agc att tca tac ctg aag gat aat gct acc att gag ctt ttc ttt ctg      797
 Ser Ile Ser Tyr Leu Lys Asp Asn Ala Thr Ile Glu Leu Phe Phe Leu
                 125                 130                 135

 aac gcg aag tcc tgc atc tac aag gag ctt att gac gtt gac agc gaa      845
 Asn Ala Lys Ser Cys Ile Tyr Lys Glu Leu Ile Asp Val Asp Ser Glu
             140                 145                 150

 gtg gtg ttt gaa tta gct tcc tat att tta cag gag gca aag gga gat      893
 Val Val Phe Glu Leu Ala Ser Tyr Ile Leu Gln Glu Ala Lys Gly Asp
         155                 160                 165

 ttt tct agc aat gaa gtt gtg agg agt gac ttg aag aag ctg cca gcc      941
 Phe Ser Ser Asn Glu Val Val Arg Ser Asp Leu Lys Lys Leu Pro Ala
     170                 175                 180

 ctt ccc acc caa gcc ctg aag gag cac cct tcc ctg gcc tac tgt gaa      989
 Leu Pro Thr Gln Ala Leu Lys Glu His Pro Ser Leu Ala Tyr Cys Glu
 185                 190                 195                 200

 gac aga gtc att gag cac tac aag aaa ctg aac ggt cag aca aga ggt     1037
 Asp Arg Val Ile Glu His Tyr Lys Lys Leu Asn Gly Gln Thr Arg Gly
                 205                 210                 215

 caa gca atc gta aac tac atg agc atc gtg ggg tct ctc cca acc tac     1085
 Gln Ala Ile Val Asn Tyr Met Ser Ile Val Gly Ser Leu Pro Thr Tyr
             220                 225                 230

 ggg gtt cac tat tat gca gtg aag gac aag cag ggc ata cca tgg tgg     1133
 Gly Val His Tyr Tyr Ala Val Lys Asp Lys Gln Gly Ile Pro Trp Trp
         235                 240                 245

 ctg ggc ctg agc tac aaa ggg atc ttc cag tat gac tac cat gat aaa     1181
 Leu Gly Leu Ser Tyr Lys Gly Ile Phe Gln Tyr Asp Tyr His Asp Lys
     250                 255                 260

 gtg aag cca aga aag ata ttc caa tgg aga cag ttg gaa aac ctg tac     1229
 Val Lys Pro Arg Lys Ile Phe Gln Trp Arg Gln Leu Glu Asn Leu Tyr
 265                 270                 275                 280

 ttc aga gaa aag aag ttt tcc gtg gaa gtt cat gac cca cgc agg gct     1277
 Phe Arg Glu Lys Lys Phe Ser Val Glu Val His Asp Pro Arg Arg Ala
                 285                 290                 295

 tca gtg aca agg agg acg ttt ggg cac agc ggc att gca gtg cac acg     1325
 Ser Val Thr Arg Arg Thr Phe Gly His Ser Gly Ile Ala Val His Thr
             300                 305                 310

 tgg tat gca tgt ccg gca ttg atc aag tcc atc tgg gct atg gcc ata     1373
 Trp Tyr Ala Cys Pro Ala Leu Ile Lys Ser Ile Trp Ala Met Ala Ile
         315                 320                 325

 agc caa cac cag ttc tat ctg gac aga aag cag agt aag tcc aaa atc     1421
 Ser Gln His Gln Phe Tyr Leu Asp Arg Lys Gln Ser Lys Ser Lys Ile
     330                 335                 340

 cat gca gca cgc agc ctg agt gag atc gcc atc gac ctg acc gag acg     1469
 His Ala Ala Arg Ser Leu Ser Glu Ile Ala Ile Asp Leu Thr Glu Thr
 345                 350                 355                 360

 ggg acg ctg aag acc tcg aag ctg gcc aac atg ggt agc aag ggg aag     1517
 Gly Thr Leu Lys Thr Ser Lys Leu Ala Asn Met Gly Ser Lys Gly Lys
                 365                 370                 375

 atc atc agc ggc agc agc ggc agc ctg ctg tct tca ggt agg cag agg     1565
 Ile Ile Ser Gly Ser Ser Gly Ser Leu Leu Ser Ser Gly Arg Gln Arg
             380                 385                 390

 cca gct gga ggg acg ccc cct gag cat ggc tgg gac ccc aga ggg gac     1613
 Pro Ala Gly Gly Thr Pro Pro Glu His Gly Trp Asp Pro Arg Gly Asp
         395                 400                 405

 cca gga agg tgg gga gag ctg cag ctg ggg aga ctg cag ggc aag ctg     1661
 Pro Gly Arg Trp Gly Glu Leu Gln Leu Gly Arg Leu Gln Gly Lys Leu
     410                 415                 420

 ctc caa agc tgg ctt tgc ttt cca gac caa ggt tgg gat cca aat gcg     1709
 Leu Gln Ser Trp Leu Cys Phe Pro Asp Gln Gly Trp Asp Pro Asn Ala
 425                 430                 435                 440

 aat ctg aga aaa ctg ctc cca gga atc aaa tag tggaagg                 1749
 Asn Leu Arg Lys Leu Leu Pro Gly Ile Lys 
                 445                 450





      <210> 368
      <211> 2524
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (354)..(1586)

      <400> 368
 ggaattccct ggtcgacgat ctcgtgcgtg ttgtctttac ctgccaggtt acagccaacc     60

 cggagatctt gggctacagg tgggccaaaa ggggtttctt gattgaaaac gcccacgaga    120

 gtcgctatga gacaaatgtg gattattcct ttttcacgga gcctgtgtct tgtgaggttc    180

 acaacaaagt gggaagcacc aatgtcggca ctttagtaaa tgtccacttt gctccccgga    240

 ttgtagttga ccccaaaccc acaaccacag acattggctc tgatgtgacc cttacctgtg    300

 tctgggttgg gaatcccccc ctcactctca cctggaccaa aaaggactca aat   atg     356
                                                              Met
                                                                1

 gtc ctg agt aac agc aac cag ctg ctg ctg aag tcg gtg act cag gca      404
 Val Leu Ser Asn Ser Asn Gln Leu Leu Leu Lys Ser Val Thr Gln Ala
               5                  10                  15

 gac gct ggc acc tac acc tgc cgg gcc atc gtg cct cga atc gga gtg      452
 Asp Ala Gly Thr Tyr Thr Cys Arg Ala Ile Val Pro Arg Ile Gly Val
          20                  25                  30

 gct gag cgg gag gtg ccg ctc tat gtg aac ggg ccc ccc atc atc tcc      500
 Ala Glu Arg Glu Val Pro Leu Tyr Val Asn Gly Pro Pro Ile Ile Ser
      35                  40                  45

 agt gag gca gtg cag tat gct gtg agg ggt gac ggt ggc aag gtg gag      548
 Ser Glu Ala Val Gln Tyr Ala Val Arg Gly Asp Gly Gly Lys Val Glu
  50                  55                  60                  65

 tgt ttc att ggg agc aca cca ccc cca gac cgc ata gca tgg gcc tgg      596
 Cys Phe Ile Gly Ser Thr Pro Pro Pro Asp Arg Ile Ala Trp Ala Trp
                  70                  75                  80

 aag gag aac ttc ttg gag gtg ggg acc ctg gaa cgc tat aca gtg gag      644
 Lys Glu Asn Phe Leu Glu Val Gly Thr Leu Glu Arg Tyr Thr Val Glu
              85                  90                  95

 agg acc aac tca ggc agt ggg gtg cta tcc acg ctc acc atc aac aat      692
 Arg Thr Asn Ser Gly Ser Gly Val Leu Ser Thr Leu Thr Ile Asn Asn
         100                 105                 110

 gtc atg gag gcc gac ttt cag act cac tac aac tgc acc gcc tgg aac      740
 Val Met Glu Ala Asp Phe Gln Thr His Tyr Asn Cys Thr Ala Trp Asn
     115                 120                 125

 agc ttc ggg cca ggc aca gcc atc atc cag ctg gaa gag cga gag gtg      788
 Ser Phe Gly Pro Gly Thr Ala Ile Ile Gln Leu Glu Glu Arg Glu Val
 130                 135                 140                 145

 tta cct gtg ggc atc ata gct ggg gcc acc atc ggc gcg agc atc ctg      836
 Leu Pro Val Gly Ile Ile Ala Gly Ala Thr Ile Gly Ala Ser Ile Leu
                 150                 155                 160

 ctc atc ttc ttc ttc atc gcc ttg gta ttc ttc ctc tac cgg cgc cgc      884
 Leu Ile Phe Phe Phe Ile Ala Leu Val Phe Phe Leu Tyr Arg Arg Arg
             165                 170                 175

 aaa ggc agt cgc aaa gac gtg acc ctg agg aag ctg gat atc aag gtg      932
 Lys Gly Ser Arg Lys Asp Val Thr Leu Arg Lys Leu Asp Ile Lys Val
         180                 185                 190

 gag aca gtg aac cga gag cca ctt acg atg cat tct gac cgg gag gat      980
 Glu Thr Val Asn Arg Glu Pro Leu Thr Met His Ser Asp Arg Glu Asp
     195                 200                 205

 gac acc gcc agc gtc tcc aca gca acc cgg gtc atg aag gcc atc tac     1028
 Asp Thr Ala Ser Val Ser Thr Ala Thr Arg Val Met Lys Ala Ile Tyr
 210                 215                 220                 225

 tcg tcg ttt aag gat gat gtg gat ctg aag cag gac ctg cgc tgc gac     1076
 Ser Ser Phe Lys Asp Asp Val Asp Leu Lys Gln Asp Leu Arg Cys Asp
                 230                 235                 240

 acc atc gac acc cgg gag gag tat gag atg aag gac ccc acc aat ggc     1124
 Thr Ile Asp Thr Arg Glu Glu Tyr Glu Met Lys Asp Pro Thr Asn Gly
             245                 250                 255

 tac tac aac gtg cgt gcc cat gaa gac cgc ccg tct tcc agg gca gtg     1172
 Tyr Tyr Asn Val Arg Ala His Glu Asp Arg Pro Ser Ser Arg Ala Val
         260                 265                 270

 ctc tat gct gac tac cgt gcc cct ggc cct gcc cgc ttc gac ggc cgc     1220
 Leu Tyr Ala Asp Tyr Arg Ala Pro Gly Pro Ala Arg Phe Asp Gly Arg
     275                 280                 285

 ccc tca tcc cgt ctc tcc cac tcc agc ggc tat gcc cag ctc aac acc     1268
 Pro Ser Ser Arg Leu Ser His Ser Ser Gly Tyr Ala Gln Leu Asn Thr
 290                 295                 300                 305

 tat agc cgg ggc cct gcc tct gac tat ggc cct gag ccc aca ccc cct     1316
 Tyr Ser Arg Gly Pro Ala Ser Asp Tyr Gly Pro Glu Pro Thr Pro Pro
                 310                 315                 320

 ggc cct gct gcc cca gct ggc act gac aca acc agc cag ctg tcc tac     1364
 Gly Pro Ala Ala Pro Ala Gly Thr Asp Thr Thr Ser Gln Leu Ser Tyr
             325                 330                 335

 gag aac tat gag aag ttc aac tcc cat ccc ttc cct ggg gca gct ggg     1412
 Glu Asn Tyr Glu Lys Phe Asn Ser His Pro Phe Pro Gly Ala Ala Gly
         340                 345                 350

 tac ccc acc tac cga ctg ggc tac ccc cag gcc cca ccc tct ggc ctg     1460
 Tyr Pro Thr Tyr Arg Leu Gly Tyr Pro Gln Ala Pro Pro Ser Gly Leu
     355                 360                 365

 gag cgg acc cca tat gag gcg tat gac ccc att ggc aag tac gcc aca     1508
 Glu Arg Thr Pro Tyr Glu Ala Tyr Asp Pro Ile Gly Lys Tyr Ala Thr
 370                 375                 380                 385

 gcc act cga ttc tcc tac acc tcc cag cac tcg gac tac ggc cag cga     1556
 Ala Thr Arg Phe Ser Tyr Thr Ser Gln His Ser Asp Tyr Gly Gln Arg
                 390                 395                 400

 ttc cag cag cgc atg cag act cac gtg tag g ggccagagcc tggctggggc     1607
 Phe Gln Gln Arg Met Gln Thr His Val 
             405                 410

 atctctgcgg ggcagaggag aaggctttcg cagctgttcc ctgatattca gggacattgc   1667

 tcattgctcc cttctcggac cagccttctt cctcccacca tggcaggtgg ggagcaggtc   1727

 tcccagagac accccgtccc gaggatggtg ctctgtgcat gccccagcct cctgggcctg   1787

 cccttccctc ttcttcggga ggatgtgtct cttctgacct gcactcttgc ctgaccctag   1847

 aatggggaca gggaaagtga aggttaggga aagcagaggg gggcactttt tagcattccc   1907

 tttctatccc acccctctga tctcccataa gtggaaatgg gggtacccag ggatgggcag   1967

 gctttggcct agggacatga agtatgggag tgggtggctg tggcacagac aggtggaaaa   2027

 cgggatagcc tggccagtcc ctctgttgtc tgcattcgtg ccctgggtgc ctctctcctt   2087

 cctcagggta ctgcagaagg gagcgaacag ggtactgttc gctcttgtct acagaacagc   2147

 cctggcactg cattcaaatc cagtcttcat tcagctggga tcaaaatgcc agtcaccttg   2207

 gctacccact gtggacagct gtctgtcagc atgcagaggg atccaggaat ccccccggca   2267

 gcacggcccg ctttccttct cctccatgct gggccagcca gataagtcag ggtcctggtg   2327

 gagaaagaaa ggctaggacc atgtcctcat tgacccagat actgctgtgt gctgcacagc   2387

 agtgaaccaa cactagaggg agccacacaa gcctcctctc cccagtctgc cccacttcct   2447

 ggctttaact cttgagctgg tttggggagt ggtgaggtag gggtgggggt gctgtaggct   2507

 ctttttcaaa aaaaaac                                                  2524




      <210> 369
      <211> 2105
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(652)

      <400> 369
 agcccaagat ttctagggca ttggcgcgct gctgggtgac ttccgggctc aagttgcaag     60

 ggggcgggcc gggccggagg tggagtctcc cgccaattga agcctccgct ataaattgaa    120

 ctccctgcac tgctgaagcc cagatgcctc gccaggccac gtcgcggttg gtggtcggag    180

 agggcgaggg gtcccagggg gcttcgggcc tgcagccacc  atg ctc cac tcc ctg     235
                                              Met Leu His Ser Leu
                                                1               5

 ctg ctt cac tcc ttg agg ctc tgc gcc cag acc gcc tcg tgc ctc gtg      283
 Leu Leu His Ser Leu Arg Leu Cys Ala Gln Thr Ala Ser Cys Leu Val
                  10                  15                  20

 ctc ttc ccg cgc ttc ctc ggc acg gcc ttc atg ctc tgg ctt ctc gat      331
 Leu Phe Pro Arg Phe Leu Gly Thr Ala Phe Met Leu Trp Leu Leu Asp
              25                  30                  35

 ttc ttg tgt atc cgc aag cat ttc ctg ggc cgc cgc cgc cgg ggc aag      379
 Phe Leu Cys Ile Arg Lys His Phe Leu Gly Arg Arg Arg Arg Gly Lys
          40                  45                  50

 ccc gag ccc gaa gtg gag ctc aac agt gaa ggc gag gag gtg cct ccc      427
 Pro Glu Pro Glu Val Glu Leu Asn Ser Glu Gly Glu Glu Val Pro Pro
      55                  60                  65

 gat gac ccg ccc atc tgc gtg tcc gac gac aac cgc ctg tgc acc ctg      475
 Asp Asp Pro Pro Ile Cys Val Ser Asp Asp Asn Arg Leu Cys Thr Leu
  70                  75                  80                  85

 gcg tcg ctc aag gcg gtg tgg cat ggc cag aag ttg gat ttc ttc aag      523
 Ala Ser Leu Lys Ala Val Trp His Gly Gln Lys Leu Asp Phe Phe Lys
                  90                  95                 100

 cag gcg cac gag ggc ggt ccg gcg ccc aac tcc gag gtg gtt ctg ccc      571
 Gln Ala His Glu Gly Gly Pro Ala Pro Asn Ser Glu Val Val Leu Pro
             105                 110                 115

 gac ggc ttc cag agc cag cac atc ctc gac tac gcg caa ggg aac cgc      619
 Asp Gly Phe Gln Ser Gln His Ile Leu Asp Tyr Ala Gln Gly Asn Arg
         120                 125                 130

 ccg ctg gtt ctc aat ttc ggc agc tgc acc tga ccaccgtt catggcgcgc      670
 Pro Leu Val Leu Asn Phe Gly Ser Cys Thr 
     135                 140

 atgagcgcct tccagcgcct ggtcactaag taccagcgcg acgtcgactt cctcatcatc    730

 tacatcgagg aagcgcaccc ctccgacggc tgggtcacca cggactctcc ctacatcatc    790

 ccacagcacc ggagcctgga ggaccgggtc agcgcagcga gggtactgca gcaaggtgca    850

 cccggctgcg ctctggtcct cgacaccatg gccaactcca gcagctcggc ctatggcgcc    910

 tacttcgagc gtctctatgt catccagagt ggcactatta tgtaccaggg cggccgtggc    970

 cccgacggct accaggtctc tgagctgcgc acttggttgg aacgctatga tgagcaactg   1030

 cacggcgctc ggccccggag ggtgtaaaca tccaacggac aattgactga acttggtggg   1090

 ctgggccttc gagccttcga agcccacgtg caagcgcctc aaaccaagtc acgcttggcg   1150

 aggccccagt gacactgatg tgctgagcca ccatttcaga ctgagtctgc accctcagcc   1210

 acatgaacaa tctcccctac ctccctggga ctctgcttct gtaactgtct cattcacacc   1270

 tgcctggctc actggaaatc ctcttttgag cgcgggatat ggcttgccct tgtccgtgtg   1330

 cccccaggac tttgcctcta cagcattttc ttacaccccc tccccagcgt gccctcagcc   1390

 aagtgctttg gcccggtgct tcccgcagct gcacagagac cttggccacg cccgcgcgcc   1450

 ctgagcgcag ctgggttcca ggagactctc agctcagctg agctagttgc ctggcaccca   1510

 cctgtcgcgc gcggagaggg ggttccctgt tgcttttgtg tctgtttcct gtccctggta   1570

 ggggaagtga tgtcgtggat ggggaggggt gggcagggta gtttcccccg cttgttttgg   1630

 gtgcacagga gccccactgc tgatgacgaa ctatctctaa ctggtcttga ccacgagcta   1690

 gttctgaatt gcaggggcct caaagcagca cctaaacctt gagggggagg gtgctctggg   1750

 tttccgtgag gtaaccacct taaatgggag ggaagttggg gtgtctgctt tgggaccaga   1810

 ggaagatagc ttgagaggca ttggcgaggt tcgcagcgcc ccagggagag agaaaaagct   1870

 gagactcctg gggaatgacg ttggggtgat ggagtccggg gaaagagagg tggggggaga   1930

 gcctgaggtc cccaagtgag gggagtccta ggcagagctg ctgattgtgg ggctgggagg   1990

 tggagggccc ctgattcgaa ggccatttgg tgagtgtttt gctggaaata tttcctgtat   2050

 ataaacttct ttcaatctac aataataaag gcttgaggta aaaaaaaaaa aaaaa        2105




      <210> 370
      <211> 1993
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(1623)

      <400> 370
 tggaaagatg ttacttcatc tcccaggttt gctcactgca aatacaatcc tgagaactga     60

 actagggcct taaagtcctg acatgcatgg cttggttttg tggattgcct ctctcaacag    120

 gtggtgaaat ttaccaaatc ctttgaattg     atg tcc cca aag tgc agt gct     171
                                      Met Ser Pro Lys Cys Ser Ala
                                        1               5

 gat gct gag aac agt ttc aaa gaa agc atg gag aaa tca tca tac tcc      219
 Asp Ala Glu Asn Ser Phe Lys Glu Ser Met Glu Lys Ser Ser Tyr Ser
          10                  15                  20

 gac tgg cta ata aat aac agc att gct gag ctg gtt gct tca aca ggc      267
 Asp Trp Leu Ile Asn Asn Ser Ile Ala Glu Leu Val Ala Ser Thr Gly
      25                  30                  35

 ctt cca gtg aac atc agt gat gcc tac cag gat ccg cgc ttt gat gca      315
 Leu Pro Val Asn Ile Ser Asp Ala Tyr Gln Asp Pro Arg Phe Asp Ala
  40                  45                  50                  55

 gag gca gac cag ata tct ggt ttt cac ata aga tct gtt ctt tgt gtc      363
 Glu Ala Asp Gln Ile Ser Gly Phe His Ile Arg Ser Val Leu Cys Val
                  60                  65                  70

 cct att tgg aat agc aac cac caa ata att gga gtg gct caa gtg tta      411
 Pro Ile Trp Asn Ser Asn His Gln Ile Ile Gly Val Ala Gln Val Leu
              75                  80                  85

 aac aga ctt gat ggg aaa cct ttt gat gat gca gat caa cga ctt ttt      459
 Asn Arg Leu Asp Gly Lys Pro Phe Asp Asp Ala Asp Gln Arg Leu Phe
          90                  95                 100

 gag gct ttt gtc atc ttt tgt gga ctt ggc atc aac aac aca att atg      507
 Glu Ala Phe Val Ile Phe Cys Gly Leu Gly Ile Asn Asn Thr Ile Met
     105                 110                 115

 tat gat caa gtg aag aag tcc tgg gcc aag cag tct gtg gct ctt gat      555
 Tyr Asp Gln Val Lys Lys Ser Trp Ala Lys Gln Ser Val Ala Leu Asp
 120                 125                 130                 135

 gtg cta tca tac cat gca aca tgt tca aaa gct gaa gtt gac aag ttt      603
 Val Leu Ser Tyr His Ala Thr Cys Ser Lys Ala Glu Val Asp Lys Phe
                 140                 145                 150

 aag gca gcc aac atc cct ctg gtg tca gaa ctt gcc atc gat gac att      651
 Lys Ala Ala Asn Ile Pro Leu Val Ser Glu Leu Ala Ile Asp Asp Ile
             155                 160                 165

 cat ttt gat gac ttt tct ctc gac gtt gat gcc atg atc aca gct gct      699
 His Phe Asp Asp Phe Ser Leu Asp Val Asp Ala Met Ile Thr Ala Ala
         170                 175                 180

 ctc cgg atg ttc atg gag ctg ggg atg gta cag aaa ttt aaa att gac      747
 Leu Arg Met Phe Met Glu Leu Gly Met Val Gln Lys Phe Lys Ile Asp
     185                 190                 195

 tat gag aca ctg tgt agg tgg ctt ttg aca gtg agg aaa aac tat cgg      795
 Tyr Glu Thr Leu Cys Arg Trp Leu Leu Thr Val Arg Lys Asn Tyr Arg
 200                 205                 210                 215

 atg gtt cta tac cac aac tgg aga cat gcc ttc aac gtg tgt cag ctg      843
 Met Val Leu Tyr His Asn Trp Arg His Ala Phe Asn Val Cys Gln Leu
                 220                 225                 230

 atg ttc gcg atg tta acc act gct ggg ttt caa gac att ctg acc gag      891
 Met Phe Ala Met Leu Thr Thr Ala Gly Phe Gln Asp Ile Leu Thr Glu
             235                 240                 245

 gtg gaa att tta gcg gtg att gtg gga tgc ctg tgt cat gac ctc gac      939
 Val Glu Ile Leu Ala Val Ile Val Gly Cys Leu Cys His Asp Leu Asp
         250                 255                 260

 cac agg gga acc aac aat gcc ttc caa gct aag agt ggc tct gcc ctg      987
 His Arg Gly Thr Asn Asn Ala Phe Gln Ala Lys Ser Gly Ser Ala Leu
     265                 270                 275

 gcc caa ctc tat gga acc tct gct acc ttg gag cat cac cat ttc aac     1035
 Ala Gln Leu Tyr Gly Thr Ser Ala Thr Leu Glu His His His Phe Asn
 280                 285                 290                 295

 cac gcc gtg atg atc ctt caa agt gag ggt cac aat atc ttt gct aac     1083
 His Ala Val Met Ile Leu Gln Ser Glu Gly His Asn Ile Phe Ala Asn
                 300                 305                 310

 ctg tcc tcc aag gaa tat agt gac ctt atg cag ctt ttg aag cag tca     1131
 Leu Ser Ser Lys Glu Tyr Ser Asp Leu Met Gln Leu Leu Lys Gln Ser
             315                 320                 325

 ata ttg gca aca gac ctc acg ctg tac ttt gag agg aga act gaa ttc     1179
 Ile Leu Ala Thr Asp Leu Thr Leu Tyr Phe Glu Arg Arg Thr Glu Phe
         330                 335                 340

 ttt gaa ctt gtc agt aaa gga gaa tac gat tgg aac atc aaa aac cat     1227
 Phe Glu Leu Val Ser Lys Gly Glu Tyr Asp Trp Asn Ile Lys Asn His
     345                 350                 355

 cgt gat ata ttt cga tca atg tta atg aca gcc tgt gac ctt gga gcc     1275
 Arg Asp Ile Phe Arg Ser Met Leu Met Thr Ala Cys Asp Leu Gly Ala
 360                 365                 370                 375

 gtg acc aaa ccg tgg gag atc tcc aga cag gtg gca gaa ctt gta acc     1323
 Val Thr Lys Pro Trp Glu Ile Ser Arg Gln Val Ala Glu Leu Val Thr
                 380                 385                 390

 agt gag ttc ttc gaa caa gga gat cgg gag aga tta gag ctc aaa ctc     1371
 Ser Glu Phe Phe Glu Gln Gly Asp Arg Glu Arg Leu Glu Leu Lys Leu
             395                 400                 405

 act cct tca gca att ttt gat cgg aac cgg aag gat gaa ctg cct cgg     1419
 Thr Pro Ser Ala Ile Phe Asp Arg Asn Arg Lys Asp Glu Leu Pro Arg
         410                 415                 420

 ttg caa ctg gag tgg att gat agc atc tgc atg cct ttg tat cag gca     1467
 Leu Gln Leu Glu Trp Ile Asp Ser Ile Cys Met Pro Leu Tyr Gln Ala
     425                 430                 435

 ctg gtg aag gtc aac gtg aaa ctg aag ccg atg cta gat tca gta gct     1515
 Leu Val Lys Val Asn Val Lys Leu Lys Pro Met Leu Asp Ser Val Ala
 440                 445                 450                 455

 aca aac aga agt aag tgg gaa gag cta cac caa aaa cga ctg ctg gcc     1563
 Thr Asn Arg Ser Lys Trp Glu Glu Leu His Gln Lys Arg Leu Leu Ala
                 460                 465                 470

 tca act gcc tca tcc tcc tcc cct gcc agt gtt atg gta gcc aag gaa     1611
 Ser Thr Ala Ser Ser Ser Ser Pro Ala Ser Val Met Val Ala Lys Glu
             475                 480                 485

 gac agg aac taa acc tccaggtcag ctgcagctgc aaaatgacta cagcctgaag     1666
 Asp Arg Asn 
         490

 ggccattttc agtccagcaa tgtcatcctt ttgttctttt agctcagaaa gacctaacat   1726

 ctcaaggatg cactgggaac catgcctggg ctttcacctt gaagcatggt cagcagcaga   1786

 gagagcaacg ggaaggacaa agaaagaggt ggggcaggga gcacacccca ggaccctcac   1846

 ttttccctaa tgaacacgca tgggctgaaa tgaaggctct gggtagggga ctgttttgga   1906

 tccaaggacc tgtggacagt cggcctactt actctgagct gagggaacac tgaacagtaa   1966

 aagcgtcatt agcgctgctt cattttg                                       1993




      <210> 371
      <211> 481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(379)

      <400> 371
 tgtgcctaat ttggcaagat aggattcacc tttcaggaca attaaatgaa agtcagagcc     60

 tggtccggct ccggagaagt tagaccctcg gagctggtct cggactgctg gggcgtcacc    120

 ccttcagcaa cccccgctga cc atg gca gta ttt cat gac gag gtg gaa atc     172
                          Met Ala Val Phe His Asp Glu Val Glu Ile
                            1               5                  10

 gag gac ttc caa tat gac gag gac tcg gag aca tat ttc tgt ccc tgc      220
 Glu Asp Phe Gln Tyr Asp Glu Asp Ser Glu Thr Tyr Phe Cys Pro Cys
                  15                  20                  25

 cca tgc gga gat aac ttc tcc atc acc aag gaa gag ctg gag aat ggg      268
 Pro Cys Gly Asp Asn Phe Ser Ile Thr Lys Glu Glu Leu Glu Asn Gly
              30                  35                  40

 gaa ggt gtg gca atg tgt cca ggc tgc tct ctc att ata aaa gtg att      316
 Glu Gly Val Ala Met Cys Pro Gly Cys Ser Leu Ile Ile Lys Val Ile
          45                  50                  55

 tat gac aaa gat cag ttt gcg tgt gga gaa aca gtg cca gtg cct tca      364
 Tyr Asp Lys Asp Gln Phe Ala Cys Gly Glu Thr Val Pro Val Pro Ser
      60                  65                  70

 gtc aac aaa gaa tga gttaaatgct aaggaagcct tcaggaatcc gaaccctgaa      419
 Val Asn Lys Glu 
  75

 cagctggaaa tgagcccaga tagaaacttc aaatgcaaag ctccgaattc caccacgctg    479

 ag                                                                   481




      <210> 372
      <211> 1373
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (197)..(1294)

      <400> 372
 gcgctcgtga accgcccgga aatcccggct cgacccacgc gtccggaggc caactccagc     60

 tccttacaaa gaaatccttc tgatggttag gaatggccca tgagctcctg tttcctggag    120

 gcgtgtgtca ggcaggggct gcacgccagc ccagccccca gtgctgagag ggaattcctg    180

 cactgaatgc ccagac    atg ttc tgc ctt ttc cat ggg aag aga tac tcc     229
                      Met Phe Cys Leu Phe His Gly Lys Arg Tyr Ser
                        1               5                  10

 ccc ggc gag agc tgg cac ccc tac ttg gag cca caa ggc ctg atg tac      277
 Pro Gly Glu Ser Trp His Pro Tyr Leu Glu Pro Gln Gly Leu Met Tyr
              15                  20                  25

 tgc ctg cgc tgt acc tgc tca gag ggc gcc cat gtg agt tgt tac cgc      325
 Cys Leu Arg Cys Thr Cys Ser Glu Gly Ala His Val Ser Cys Tyr Arg
          30                  35                  40

 ctc cac tgt ccg cct gtc cac tgc ccc cag cct gtg acg gag cca cag      373
 Leu His Cys Pro Pro Val His Cys Pro Gln Pro Val Thr Glu Pro Gln
      45                  50                  55

 caa tgc tgt ccc aag tgt gtg gaa cct cac act ccc tct gga ctc cgg      421
 Gln Cys Cys Pro Lys Cys Val Glu Pro His Thr Pro Ser Gly Leu Arg
  60                  65                  70                  75

 gcc cca cca aag tcc tgc cag cac aac ggg acc atg tac caa cac gga      469
 Ala Pro Pro Lys Ser Cys Gln His Asn Gly Thr Met Tyr Gln His Gly
                  80                  85                  90

 gag atc ttc agt gcc cat gag ctg ttc ccc tcc cgc ctg ccc aac cag      517
 Glu Ile Phe Ser Ala His Glu Leu Phe Pro Ser Arg Leu Pro Asn Gln
              95                 100                 105

 tgt gtc ctc tgc agc tgc aca gag ggc cag atc tac tgc ggc ctc aca      565
 Cys Val Leu Cys Ser Cys Thr Glu Gly Gln Ile Tyr Cys Gly Leu Thr
         110                 115                 120

 acc tgc ccc gaa cca ggc tgc cca gca ccc ctc ccg ctg cca gac tcc      613
 Thr Cys Pro Glu Pro Gly Cys Pro Ala Pro Leu Pro Leu Pro Asp Ser
     125                 130                 135

 tgc tgc caa gcc tgc aaa gat gag gca agt gag caa tcg gat gaa gag      661
 Cys Cys Gln Ala Cys Lys Asp Glu Ala Ser Glu Gln Ser Asp Glu Glu
 140                 145                 150                 155

 gac agt gtg cag tcg ctc cat ggg gtg aga cat cct cag gat cca tgt      709
 Asp Ser Val Gln Ser Leu His Gly Val Arg His Pro Gln Asp Pro Cys
                 160                 165                 170

 tcc agt gat gct ggg aga aag aga ggc ccg ggc acc cca gcc ccc act      757
 Ser Ser Asp Ala Gly Arg Lys Arg Gly Pro Gly Thr Pro Ala Pro Thr
             175                 180                 185

 ggc ctc agc gcc cct ctg agc ttc atc cct cgc cac ttc aga ccc aag      805
 Gly Leu Ser Ala Pro Leu Ser Phe Ile Pro Arg His Phe Arg Pro Lys
         190                 195                 200

 gga gca ggc agc aca act gtc aag atc gtc ctg aag gag aaa cat aag      853
 Gly Ala Gly Ser Thr Thr Val Lys Ile Val Leu Lys Glu Lys His Lys
     205                 210                 215

 aaa gcc tgt gtg cat ggc ggg aag acg tac tcc cac ggg gag gtg tgg      901
 Lys Ala Cys Val His Gly Gly Lys Thr Tyr Ser His Gly Glu Val Trp
 220                 225                 230                 235

 cac ccg gcc ttc cgt gcc ttc ggc ccc ttg ccc tgc atc cta tgc acc      949
 His Pro Ala Phe Arg Ala Phe Gly Pro Leu Pro Cys Ile Leu Cys Thr
                 240                 245                 250

 tgt gag gat ggc cgc cag gac tgc cag cgt gtg acc tgt ccc acc gag      997
 Cys Glu Asp Gly Arg Gln Asp Cys Gln Arg Val Thr Cys Pro Thr Glu
             255                 260                 265

 tac ccc tgc cgt cac ccc gag aaa gtg gct ggg aag tgc tgc aag att     1045
 Tyr Pro Cys Arg His Pro Glu Lys Val Ala Gly Lys Cys Cys Lys Ile
         270                 275                 280

 tgc cca gag gac aaa gca gac cct ggc cac agt gag atc agt tct acc     1093
 Cys Pro Glu Asp Lys Ala Asp Pro Gly His Ser Glu Ile Ser Ser Thr
     285                 290                 295

 agg tgt ccc aag gca ccg ggc cgg gtc ctc gtc cac aca tcg gta tcc     1141
 Arg Cys Pro Lys Ala Pro Gly Arg Val Leu Val His Thr Ser Val Ser
 300                 305                 310                 315

 cca agc cca gac aac ctg cgt cgc ttt gcc ctg gaa cac gag gcc tcg     1189
 Pro Ser Pro Asp Asn Leu Arg Arg Phe Ala Leu Glu His Glu Ala Ser
                 320                 325                 330

 gac ttg gtg gag atc tac ctc tgg aag ctg gta aaa gga atc ttc cta     1237
 Asp Leu Val Glu Ile Tyr Leu Trp Lys Leu Val Lys Gly Ile Phe Leu
             335                 340                 345

 gcc cag acc ctg gag ctg aag gtc acg gcc agt cca gac aaa gtg acc     1285
 Ala Gln Thr Leu Glu Leu Lys Val Thr Ala Ser Pro Asp Lys Val Thr
         350                 355                 360

 aag aca taa caaagac ctaacagttg cagatatgag ctgtataatt gttgttatta     1341
 Lys Thr 
     365

 tatattaata aataagaagt tgcattaccc tc                                 1373




      <210> 373
      <211> 1507
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(954)

      <400> 373
 cccgggtcga cgatttcgtg tagcgagctg agctgacagc gcggagctgg cgctgtggag     60

 cgcagggagc cttgccggtt cctccgaccg gcgtctgcga gtacagcggc ggctaacctg    120

 ccccggcttc aggatttaca cagacgtggg gcg atg ctt gtg acc ctg cag ctc     174
                                      Met Leu Val Thr Leu Gln Leu
                                        1               5

 ctc aaa gtg aag acc agc cat gtg gag aat gac tac ata gac aac cct      222
 Leu Lys Val Lys Thr Ser His Val Glu Asn Asp Tyr Ile Asp Asn Pro
          10                  15                  20

 agc ctg gcc ctg acc acc ggc cca aag cgg acc cgg ggc ggg gcc cca      270
 Ser Leu Ala Leu Thr Thr Gly Pro Lys Arg Thr Arg Gly Gly Ala Pro
      25                  30                  35

 gag ctg gcc ccg acg ccc gcc cgc tgt gac cag gat gtc acc cac cat      318
 Glu Leu Ala Pro Thr Pro Ala Arg Cys Asp Gln Asp Val Thr His His
  40                  45                  50                  55

 tgg atc tcc ttc agc ggg cgc ccc agc tct gtg agc agc agc agc agc      366
 Trp Ile Ser Phe Ser Gly Arg Pro Ser Ser Val Ser Ser Ser Ser Ser
                  60                  65                  70

 aca tcc tct gac caa cgg ctc tta gac cac atg gca cca cca ccc gtg      414
 Thr Ser Ser Asp Gln Arg Leu Leu Asp His Met Ala Pro Pro Pro Val
              75                  80                  85

 gct gac cag gcc tca cca agg gct gtg cgc atc cag ccc aag gtg gtc      462
 Ala Asp Gln Ala Ser Pro Arg Ala Val Arg Ile Gln Pro Lys Val Val
          90                  95                 100

 cac tgc cag ccg ctg gac ctc aag ggc ccg gcg gtc cca ccc gag ctg      510
 His Cys Gln Pro Leu Asp Leu Lys Gly Pro Ala Val Pro Pro Glu Leu
     105                 110                 115

 gac aag cac ttc ttg ctg tgc gag gcc tgt ggg aag tgt aaa tgc aag      558
 Asp Lys His Phe Leu Leu Cys Glu Ala Cys Gly Lys Cys Lys Cys Lys
 120                 125                 130                 135

 gag tgt gca tcc ccc cgg acg ttg cct tcc tgc tgg gtc tgc aac cag      606
 Glu Cys Ala Ser Pro Arg Thr Leu Pro Ser Cys Trp Val Cys Asn Gln
                 140                 145                 150

 gag tgc ctg tgc tca gcc cag act ctg gtc aac tat ggc acg tgc atg      654
 Glu Cys Leu Cys Ser Ala Gln Thr Leu Val Asn Tyr Gly Thr Cys Met
             155                 160                 165

 tgt ttg gtg cag ggc atc ttc tac cac tgc acg aat gag gac gat gag      702
 Cys Leu Val Gln Gly Ile Phe Tyr His Cys Thr Asn Glu Asp Asp Glu
         170                 175                 180

 ggc tcc tgc gct gac cac ccc tgc tcc tgc tcc cgc tcc aac tgc tgc      750
 Gly Ser Cys Ala Asp His Pro Cys Ser Cys Ser Arg Ser Asn Cys Cys
     185                 190                 195

 gcc cgc tgg tcc ttc atg ggt gct ctc tcc gtg gtg ctg ccc tgc ctg      798
 Ala Arg Trp Ser Phe Met Gly Ala Leu Ser Val Val Leu Pro Cys Leu
 200                 205                 210                 215

 ctc tgc tac ctg cct gcc acc ggc tgc gtg aag ctg gcc cag cgt ggc      846
 Leu Cys Tyr Leu Pro Ala Thr Gly Cys Val Lys Leu Ala Gln Arg Gly
                 220                 225                 230

 tac gac cgt ctg cgc cgc cct ggt tgc cgc tgc aag cac acg aac agc      894
 Tyr Asp Arg Leu Arg Arg Pro Gly Cys Arg Cys Lys His Thr Asn Ser
             235                 240                 245

 gtc atc tgc aaa gca gcc agc ggg gat gcc aag acc agc agg ccc gac      942
 Val Ile Cys Lys Ala Ala Ser Gly Asp Ala Lys Thr Ser Arg Pro Asp
         250                 255                 260

 aag cct ttc tga cag tttgtgtcga agccccagtg ctctgcctgg aaacctggtt      997
 Lys Pro Phe 
     265

 ctcttctgac atctaagaag actgcagcaa ggtcagaggt tttagcctcc tgaggctgac   1057

 cttgctagtc tgcccactcc ctacccccag cttcggaaaa tacagagacc accaccacgt   1117

 accctgtatt ccccaagatg atgaagaagc actttggggc tttttttcag ggtcctgaaa   1177

 ctttgtgtca aacagacaat gcaggggcag ggtgtggttt ggggggaaat ttttcttttt   1237

 cagaagacag aacacagatg tggacacata tccggaaact gcagctgctt gaatgccttc   1297

 ccagcccctc cttctccctc cctccctccg cccccccctt cctcttttcc attgtctttg   1357

 gcactcacag gagctagctg cctgggagga attgttaact gagtaccagg gtacctttaa   1417

 agaagaccct tggagtcttc tataccttct tctccttccc catctcactc caccccactt   1477

 tgtccctgat gtcttggggg aggtgtagat                                    1507




      <210> 374
      <211> 435
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(261)

      <400> 374
 ttaggcgcc    atg tcc ggc cgc gaa ggt aag tgt tcc gga acc gtg agg      48
              Met Ser Gly Arg Glu Gly Lys Cys Ser Gly Thr Val Arg
                1               5                  10

 act gcg ggg acg gcg ggg tgg gga ccg ggc ggc agg ggc agg ccg aac       96
 Thr Ala Gly Thr Ala Gly Trp Gly Pro Gly Gly Arg Gly Arg Pro Asn
      15                  20                  25

 gtg ctc gtg tcg ccc aca ggt ggc aag aag aag cca ctg aaa cag ccc      144
 Val Leu Val Ser Pro Thr Gly Gly Lys Lys Lys Pro Leu Lys Gln Pro
  30                  35                  40                  45

 aag aag cag gcc aag gag atg gac gag gtg agg gcg ggc gcg gag gca      192
 Lys Lys Gln Ala Lys Glu Met Asp Glu Val Arg Ala Gly Ala Glu Ala
                  50                  55                  60

 ctg gcg ggt gcg ggg gcg ctg gga gac agg cct gag ttg aac acg ctc      240
 Leu Ala Gly Ala Gly Ala Leu Gly Asp Arg Pro Glu Leu Asn Thr Leu
              65                  70                  75

 tgc ctc tcc cca gga aga taa gg ctttcaagca gaaacaaaaa gaggagcaga      293
 Cys Leu Ser Pro Gly Arg 
          80

 agaaactcga ggagctaaaa gcgaaggccg cggggaaggg gcccttgggt aagtgggggc    353

 cgaatggagc tcaagctggc caaacgctat gagcacctat tgggatgagg gcgcgggcat    413

 gtctttttcc tgcctcctga ac                                             435




      <210> 375
      <211> 532
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(407)

      <400> 375
 cccgggtggt tgctggctaa    atg agc aac ttc atg aaa cct ggg aag ggg      50
                          Met Ser Asn Phe Met Lys Pro Gly Lys Gly
                            1               5                  10

 gcg ctt gtc ctg gct gga cac tac tcc gga cgc aaa gct ggc atc gtg       98
 Ala Leu Val Leu Ala Gly His Tyr Ser Gly Arg Lys Ala Gly Ile Val
                  15                  20                  25

 aaa aac att gat gat ggc acc tca gat cgc ccc tac agc cat gct ctg      146
 Lys Asn Ile Asp Asp Gly Thr Ser Asp Arg Pro Tyr Ser His Ala Leu
              30                  35                  40

 gtg gct gga att gac cgc tac ccc cgc aaa gtg aca gct gcc atg ggc      194
 Val Ala Gly Ile Asp Arg Tyr Pro Arg Lys Val Thr Ala Ala Met Gly
          45                  50                  55

 aag aag aag atc gcc aag aga tca aag ata aaa tct ttt gtg aaa gtg      242
 Lys Lys Lys Ile Ala Lys Arg Ser Lys Ile Lys Ser Phe Val Lys Val
      60                  65                  70

 tat aac tac aat cac cta atg ccc aca agg tac tct gtg gat atc ccc      290
 Tyr Asn Tyr Asn His Leu Met Pro Thr Arg Tyr Ser Val Asp Ile Pro
  75                  80                  85                  90

 ttg gac aaa act gtc gtc aat aag gat gtc ttc aga gat cct gct ctt      338
 Leu Asp Lys Thr Val Val Asn Lys Asp Val Phe Arg Asp Pro Ala Leu
                  95                 100                 105

 aaa cgc aag gcc cga cgg gag gcc aag gtc aag ttt gaa gag aga tac      386
 Lys Arg Lys Ala Arg Arg Glu Ala Lys Val Lys Phe Glu Glu Arg Tyr
             110                 115                 120

 aag aca ggc aag ggc aaa tag tt cttccagaaa ctgcggtttt agatgcaggg      439
 Lys Thr Gly Lys Gly Lys 
         125

 ggttgatcgg tgaagagtat gagaggtgtg agtagatgag gggtgtgagg gtgcgtccga    499

 gttgctggac cgcgggggcc aggttccctg gat                                 532




      <210> 376
      <211> 700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (219)..(413)

      <400> 376
 ttgtgctggt tgtgtaagcc gtgggacaca cgggaaagcc aggaagaaga ggaagagcac     60

 ccccacaccc cacccgcgtg aagaagagca accccactcc ccgcccgtgg gaagaagagc    120

 accctcacgc cgggcccgca ggaagaagag cacccccacg cccggcccgc agcatcccgc    180

 tggcttcctg gccacctctc ctcacccatc ttagaggc    atg gcc ggg ctg ggg     233
                                              Met Ala Gly Leu Gly
                                                1               5

 cat ctt tcc ctc ctt ggg cag gat gaa aca ggc gcc tat tta atc gac      281
 His Leu Ser Leu Leu Gly Gln Asp Glu Thr Gly Ala Tyr Leu Ile Asp
                  10                  15                  20

 aga gac ccc acc tac ttt ggg cct gtg ctg aac tac ctg aga cac ggc      329
 Arg Asp Pro Thr Tyr Phe Gly Pro Val Leu Asn Tyr Leu Arg His Gly
              25                  30                  35

 aag ctg gtg att aac aaa gac ctc gcg gag gaa gat gat acc acg agt      377
 Lys Leu Val Ile Asn Lys Asp Leu Ala Glu Glu Asp Asp Thr Thr Ser
          40                  45                  50

 caa ccc aaa agt tgc tgg gga gaa gtt gct ctt taa tgaa ttgcatctca      427
 Gln Pro Lys Ser Cys Trp Gly Glu Val Ala Leu 
      55                  60

 tgaatgtatc aggctgtgac ctttctgcac tctctaatga gttcatgaat ttaggccaat    487

 tatggccaca aatgctgctg ctgtcacaga gagatgccgg ataaagaaca cccaccacca    547

 gtctctgaac agggagggga gaatcaactc tgaatgtgat gtagtggcca ggagagagga    607

 ccatgttcaa caacgccaca cagatgcaaa tgacttgttt cttcaacaaa ctgcaaggga    667

 aaaaataaaa atgggggaag ctacagatta aaa                                 700




      <210> 377
      <211> 713
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (397)..(624)

      <400> 377
 tggtacagac aggtctttat tgttgacata ttttctcatt taatccttga agcaaccctg     60

 aggtaggttt tattatcccc acttcgcaga tgagtaaact gatgtcccta ggttaggtta    120

 cttgccgaag atcacacatt tactagtggc aaagccactg ataattccaa acccaagggg    180

 actcttttga gtagttcaca ggctgctgcc aaggaaagta gagcagaaaa cttcaaaggg    240

 gaaggactgg atcattgact ggagcttgag gggctcaagc accagggatg aacgaggcac    300

 attcacaggc caagaccagg actcagcagg agaagcctag agccatgtgc gagtggtcaa    360

 gcaggaagag gtcttgacgt ttggtaagag ctgaca  atg tca tca aat aca cat     414
                                          Met Ser Ser Asn Thr His
                                            1               5

 aga gct cag ctt cca ggg act gga gaa aca aga agg cct cca gca gct      462
 Arg Ala Gln Leu Pro Gly Thr Gly Glu Thr Arg Arg Pro Pro Ala Ala
              10                  15                  20

 acc agt cca ggg act ggc cac agt cag tca gac tca aag aga act gag      510
 Thr Ser Pro Gly Thr Gly His Ser Gln Ser Asp Ser Lys Arg Thr Glu
          25                  30                  35

 agg cca caa cag tct tcc aga ccc agc aac ctt tgg cat ctc agt ggt      558
 Arg Pro Gln Gln Ser Ser Arg Pro Ser Asn Leu Trp His Leu Ser Gly
      40                  45                  50

 aac tcc att cca gca aat cac cct gtt cca ggc agg gca agt cca ggg      606
 Asn Ser Ile Pro Ala Asn His Pro Val Pro Gly Arg Ala Ser Pro Gly
  55                  60                  65                  70

 aga gct gcc aca gag tga tgccat cctaacttgg ccttatgcac gaacctaagg      660
 Arg Ala Ala Thr Glu 
                  75

 caggggcctt ttacttttta aggcctggaa atctgcaaaa gccttaaaac tcc           713




      <210> 378
      <211> 392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(261)

      <400> 378
 ggcgctttat agctacacag tgct   atg cca gag cca gcg aag tct gct ccc      51
                              Met Pro Glu Pro Ala Lys Ser Ala Pro
                                1               5

 gcc ccg aaa aag ggc tcc aag aag gcg gtg act aag gcg cag aaa aaa       99
 Ala Pro Lys Lys Gly Ser Lys Lys Ala Val Thr Lys Ala Gln Lys Lys
  10                  15                  20                  25

 gac ggc aag aag cgc aag cgc agc cgc aag gag agc tat tcc atc tat      147
 Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys Glu Ser Tyr Ser Ile Tyr
                  30                  35                  40

 gtg tac aag gtt ctg aag cag gtc cac cct gac acc ggc att tcg tcc      195
 Val Tyr Lys Val Leu Lys Gln Val His Pro Asp Thr Gly Ile Ser Ser
              45                  50                  55

 aag gcc atg ggc atc atg aat tcg ttt gtg aac gac att ttc gag cgc      243
 Lys Ala Met Gly Ile Met Asn Ser Phe Val Asn Asp Ile Phe Glu Arg
          60                  65                  70

 atc gca ggg cta ccc tga gaggaa tctacatgca gagaagttca ggagactgaa      297
 Ile Ala Gly Leu Pro 
      75

 ctaacggaac gtcaggaagc gctgcgggct ggagagctgc tgttggaaca gggaggagtt    357

 ctccgggccg caccctgcct ccgtcccgca agtgg                               392




      <210> 379
      <211> 732
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (249)..(569)

      <400> 379
 tcccgggtcg acgatttcgt agggcgcagc agctgctccc tgaacacttt ctgacccaac     60

 agtcccccag tgccggacgc gccgcgccct ggcggctcta gggacccccc ccgcgcctgc    120

 acttagcccc gcgcccgagt ccacagacaa acgaatttaa aggagcaacc gaggaggcac    180

 ctgcgaaaga aagcccacac acaggtgaat ttaaaggagc agccctggtg tcacctatca    240

 gtaaaaga atg tta gaa cga ctt tcc aag ttt gaa gtt gga gat gct gaa     290
          Met Leu Glu Arg Leu Ser Lys Phe Glu Val Gly Asp Ala Glu
            1               5                  10

 aat gtt gct tca tat gac agt aag att aag aaa att gtg cat tca att      338
 Asn Val Ala Ser Tyr Asp Ser Lys Ile Lys Lys Ile Val His Ser Ile
  15                  20                  25                  30

 gta tca tcc ttt gca ttt gga cta ttt gga gtt ttc ctc gtc tta ctg      386
 Val Ser Ser Phe Ala Phe Gly Leu Phe Gly Val Phe Leu Val Leu Leu
                  35                  40                  45

 gat gtc act ctc gtc ctt gcc gac cta att ttc act gac agc aaa ctt      434
 Asp Val Thr Leu Val Leu Ala Asp Leu Ile Phe Thr Asp Ser Lys Leu
              50                  55                  60

 tat att cct ttg gag tat cgt tct att tct cta gct att gcc tta ttt      482
 Tyr Ile Pro Leu Glu Tyr Arg Ser Ile Ser Leu Ala Ile Ala Leu Phe
          65                  70                  75

 ttt ctc atg gat gtt ctt ctt cga gta ttt gta gaa ggg tca acg cca      530
 Phe Leu Met Asp Val Leu Leu Arg Val Phe Val Glu Gly Ser Thr Pro
      80                  85                  90

 ccg cct ctg cac tgc ctt cct ggc cat cat ccc agg tag agctgccctc       579
 Pro Pro Leu His Cys Leu Pro Gly His His Pro Arg 
  95                 100                 105

 ttccttctcc gcagcttttc tcatcctgca aagcaagggt gttggagcgg gccggagaga    639

 agtagagtgg gctgcgagga gaaggaaaca ggcctttcgg aggctcctca tccctcggag    699

 gtcatccctt actccaggtg atctgaacct gaa                                 732




      <210> 380
      <211> 1094
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (453)..(851)

      <400> 380
 gctatcgcgt ctgcccaccg acgaagcatg ggtgtccagg gcttccaaga gttcctggag     60

 aagcgctgtc ccggggccgt ggtgcccgtg gacctcctaa aactcgcgcg cacggtctcg    120

 cgccagcagc agcagcagca cttgcaccgc cagctgccgc cgactgcagc cctagcgccc    180

 ggggctccac gcgccgccag gggctccgtg cctctgcaac cgccgcttcc gcccgctgcc    240

 ttgggtgcct actccggggg cgcggggccg actcggcacc atcaccccgc tcaccacttc    300

 caccatcatg gccaagcgca gcccgggctg caccctccgc tgccgccgcc gccgccccct    360

 cagctgcccg gggcccgggt gctggtggac gccggctcgg cgctgccgcg gctctatggc    420

 ggctaccaga cggattgggt gtgtggcggc ca  atg gaa cgc cat gct ggg cta     473
                                      Met Glu Arg His Ala Gly Leu
                                        1               5

 ctt gtc agc gct gtg cca ggc ttg tgc cta tcc tgg cgg cga cgg cct      521
 Leu Val Ser Ala Val Pro Gly Leu Cys Leu Ser Trp Arg Arg Arg Pro
          10                  15                  20

 gga gct cgt ggt cat gtt ccc ggg ggg cct ggg caa gga ccg gct ggc      569
 Gly Ala Arg Gly His Val Pro Gly Gly Pro Gly Gln Gly Pro Ala Gly
      25                  30                  35

 cga gtg ggg ccg tcg gtg cca ggc cga gcg gca gac agc gca act gat      617
 Arg Val Gly Pro Ser Val Pro Gly Arg Ala Ala Asp Ser Ala Thr Asp
  40                  45                  50                  55

 cgt ggg aca cgt ggg caa caa ggg cac ccc tcc acc gcg ggc ctg gtt      665
 Arg Gly Thr Arg Gly Gln Gln Gly His Pro Ser Thr Ala Gly Leu Val
                  60                  65                  70

 cct gcc acc ggc ctg cct gag cca ctg cgt gag gct agc act cat ccg      713
 Pro Ala Thr Gly Leu Pro Glu Pro Leu Arg Glu Ala Ser Thr His Pro
              75                  80                  85

 ctt ccg ggt caa gca agc tgc cat gtt gtg agc tgc cct atg gag agg      761
 Leu Pro Gly Gln Ala Ser Cys His Val Val Ser Cys Pro Met Glu Arg
          90                  95                 100

 ccc aca gga aaa gaa act gag gga agc ctc caa cca aca ctc agt gag      809
 Pro Thr Gly Lys Glu Thr Glu Gly Ser Leu Gln Pro Thr Leu Ser Glu
     105                 110                 115

 gaa ctg agg ccc tca gtc caa cta cag cct gca agg aac tga attgctg      858
 Glu Leu Arg Pro Ser Val Gln Leu Gln Pro Ala Arg Asn 
 120                 125                 130

 ccaacagcca cgtacgtgag tgagcttgga agcggatcct tccccaggca agccttgaga    918

 tgactgcagc cctggctggc accttgattg aagcctgtag gagaccttga gccagaggac    978

 ccagctaagc catgcctaca gatactatga gataataaat gttgttttaa gccactaagt   1038

 ttgggggcta ctttgttaca cagaaataga taactgaaac accaaaaaaa aaaaaa       1094




      <210> 381
      <211> 1509
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(1509)

      <400> 381
 cacgagggct tctgcagcga gaagtgcttt gcggcctgcc gacgagccta cttcaagaga     60

 aataaggcta gagatgaaga tggacatgct gaaaattttc cccagcagca ctatgctaag    120

 gaaactccaa ggcttgcctt caagaataac tgcgaactac ttgtatgtga ctggtgtaag    180

 cacataagac acacaaaaga atacctggat tttggggacg gggaaagaag gcttcagttc    240

 tgcagtgcaa aatgtctcaa tcaatacaaa     atg gac att ttc tac aaa gag     291
                                      Met Asp Ile Phe Tyr Lys Glu
                                        1               5

 acc cag gcc aat ctt cca gct ggg ctg tgc agc aca tta cac cct ccc      339
 Thr Gln Ala Asn Leu Pro Ala Gly Leu Cys Ser Thr Leu His Pro Pro
          10                  15                  20

 atg gaa aat aaa gca gaa ggc acc ggg gtg cag ctg ctc act cca gac      387
 Met Glu Asn Lys Ala Glu Gly Thr Gly Val Gln Leu Leu Thr Pro Asp
      25                  30                  35

 tct tgg aat atc ccg cta aca gat gct cgg agg aag gcc ccc tcc ccg      435
 Ser Trp Asn Ile Pro Leu Thr Asp Ala Arg Arg Lys Ala Pro Ser Pro
  40                  45                  50                  55

 gtg gct aca gct ggc caa agc cag ggc cct ggc ccg tcg gcg tcc acc      483
 Val Ala Thr Ala Gly Gln Ser Gln Gly Pro Gly Pro Ser Ala Ser Thr
                  60                  65                  70

 acc gtc tct cca tct gac act gcc aac tgc tct gtc act aaa atc ccc      531
 Thr Val Ser Pro Ser Asp Thr Ala Asn Cys Ser Val Thr Lys Ile Pro
              75                  80                  85

 acg cca gtg ccc aag tcc atc ccc atc agc gag act cca aat atc cct      579
 Thr Pro Val Pro Lys Ser Ile Pro Ile Ser Glu Thr Pro Asn Ile Pro
          90                  95                 100

 cct gtc tcc gtc cag cca cct gct agc atc ggg cct ccc ctt ggc gtc      627
 Pro Val Ser Val Gln Pro Pro Ala Ser Ile Gly Pro Pro Leu Gly Val
     105                 110                 115

 ccg cct cgg agc cct ccc atg gtg atg acc aac cgc ggc ccg gtg ccg      675
 Pro Pro Arg Ser Pro Pro Met Val Met Thr Asn Arg Gly Pro Val Pro
 120                 125                 130                 135

 ctg ccc atc ttc atg gag cag cag atc atg cag cag atc cgc ccg ccc      723
 Leu Pro Ile Phe Met Glu Gln Gln Ile Met Gln Gln Ile Arg Pro Pro
                 140                 145                 150

 ttc atc cgc ggg cct ccg cac cat gcc tcc aac ccc aac agc ccc ctg      771
 Phe Ile Arg Gly Pro Pro His His Ala Ser Asn Pro Asn Ser Pro Leu
             155                 160                 165

 tcc aac ccc atg ctt ccc ggc atc ggg ccc ccg ccc ggt ggc ccc aga      819
 Ser Asn Pro Met Leu Pro Gly Ile Gly Pro Pro Pro Gly Gly Pro Arg
         170                 175                 180

 aac ctg ggc ccc act tcc agc ccc atg cac cgg ccc atg cta tcg ccc      867
 Asn Leu Gly Pro Thr Ser Ser Pro Met His Arg Pro Met Leu Ser Pro
     185                 190                 195

 cac atc cac ccc ccg agc acc ccc acc atg ccc ggg aac ccc cca ggc      915
 His Ile His Pro Pro Ser Thr Pro Thr Met Pro Gly Asn Pro Pro Gly
 200                 205                 210                 215

 ctg ctg ccc ccg ccg cct ccg ggc gcc cca ctg ccg agt ctt ccc ttc      963
 Leu Leu Pro Pro Pro Pro Pro Gly Ala Pro Leu Pro Ser Leu Pro Phe
                 220                 225                 230

 ccg cca gtg agc atg atg cca aat ggc ccg atg ccg gtg ccc cag atg     1011
 Pro Pro Val Ser Met Met Pro Asn Gly Pro Met Pro Val Pro Gln Met
             235                 240                 245

 atg aat ttc ggg ctg ccg tcg ctt gcc ccg ctg gtg ccg ccc ccg acc     1059
 Met Asn Phe Gly Leu Pro Ser Leu Ala Pro Leu Val Pro Pro Pro Thr
         250                 255                 260

 ctg ctc gtg ccg tac ccc gtg atc gtg ccc cta ccg gtg ccc atc ccc     1107
 Leu Leu Val Pro Tyr Pro Val Ile Val Pro Leu Pro Val Pro Ile Pro
     265                 270                 275

 atc ccc atc cct atc cct cac gtc agc gac tcc aag ccc ccc aag aag     1155
 Ile Pro Ile Pro Ile Pro His Val Ser Asp Ser Lys Pro Pro Lys Lys
 280                 285                 290                 295

 ctg ctg tcg cct gag gaa ccg gcg gtg agc gag cta gag tcg gtc aag     1203
 Leu Leu Ser Pro Glu Glu Pro Ala Val Ser Glu Leu Glu Ser Val Lys
                 300                 305                 310

 gag aat aac tgt gct tcc aac tgc cac ctg gac ggg gag gcg gcc aaa     1251
 Glu Asn Asn Cys Ala Ser Asn Cys His Leu Asp Gly Glu Ala Ala Lys
             315                 320                 325

 aag ctg atg ggc gag gag gcc ctg gcg ggg ggc gac aag tca gac ccg     1299
 Lys Leu Met Gly Glu Glu Ala Leu Ala Gly Gly Asp Lys Ser Asp Pro
         330                 335                 340

 aac ctt aat aac ccc gcg gac gag gac cat gcc tat gct ctg cgg atg     1347
 Asn Leu Asn Asn Pro Ala Asp Glu Asp His Ala Tyr Ala Leu Arg Met
     345                 350                 355

 ctg ccc aag acc ggc tgc gtg atc cag cct gtg cca aaa ccc gcg gag     1395
 Leu Pro Lys Thr Gly Cys Val Ile Gln Pro Val Pro Lys Pro Ala Glu
 360                 365                 370                 375

 aag gct gcc atg gca ccg tgc atc atc tcc tcg ccc atg ctc agc gcc     1443
 Lys Ala Ala Met Ala Pro Cys Ile Ile Ser Ser Pro Met Leu Ser Ala
                 380                 385                 390

 ggg cct gag gac ctg gag ccg ccg ctc aaa agg agg tgc ctc cga att     1491
 Gly Pro Glu Asp Leu Glu Pro Pro Leu Lys Arg Arg Cys Leu Arg Ile
             395                 400                 405

 aga aat cag aat aag taa                                             1509
 Arg Asn Gln Asn Lys 
         410





      <210> 382
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(595)

      <400> 382
 ccagagttac ataaagtgtg aggactcagg aggccatgga aggagccaca gctacagcgc     60

 tgacaggctg gagcatggga agccccagtc cacagcctgt gctcagcaca ccccacatgt    120

 ggcctgtgtc cagttggatt ctgtgtcttc tctgtgccat ccatgttctg tatcttcc      178                                                                 
 atg ttc tca gag agc atg att gtg ttc ata tat tct gac cct ccc cca      226
 Met Phe Ser Glu Ser Met Ile Val Phe Ile Tyr Ser Asp Pro Pro Pro
   1               5                  10                  15

 gct cta ccc atc aag ttc aca gag ggt ctg agg aac gaa gag gcc aca      274
 Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala Thr
              20                  25                  30

 gaa ggg gca aca gcc gtg ctg cgg tgt gag ctg agc aag atg gcc ccc      322
 Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu Ser Lys Met Ala Pro
          35                  40                  45

 gtg gag tgg tgg aag ggg cat gag acc ctc aga gat gga gac aga cac      370
 Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His
      50                  55                  60

 agc ctg agg cag gac ggg gcc agg tgt gag ctg cag atc cgc ggc ctc      418
 Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu Gln Ile Arg Gly Leu
  65                  70                  75                  80

 gtg gca gag gac gct ggg gag tac ctg tgc atg tgc ggg aag gag agg      466
 Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met Cys Gly Lys Glu Arg
                  85                  90                  95

 acc tca gcc atg ctc acc gtc agg ggt aaa ggc cac atg cag cca agc      514
 Thr Ser Ala Met Leu Thr Val Arg Gly Lys Gly His Met Gln Pro Ser
             100                 105                 110

 agc acc atg ctc tca tgt cca cgt gtt gac ttg acg cca tcc gtc tcg      562
 Ser Thr Met Leu Ser Cys Pro Arg Val Asp Leu Thr Pro Ser Val Ser
         115                 120                 125

 ggg tgc cta atg agt gga tgc caa gat cta tga acgctgcg agctggcggc      613
 Gly Cys Leu Met Ser Gly Cys Gln Asp Leu 
     130                 135

 aagactggag agagcagggc tgaacggct                                      642




      <210> 383
      <211> 720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (85)..(384)

      <400> 383
 atttggccct cgaggcacga gattcggcac gagggtgagt ctttcagtgg agccagggtc     60

 tggtttgtcg tgaggagctc cgcg   atg tcc tct caa cag agc gcc gtt tcc     111
                              Met Ser Ser Gln Gln Ser Ala Val Ser
                                1               5

 gcc aaa ggc ttt tcc aag ggg tcg tcc cag ggc ccc gct ccg tgt ccc      159
 Ala Lys Gly Phe Ser Lys Gly Ser Ser Gln Gly Pro Ala Pro Cys Pro
  10                  15                  20                  25

 gcc ccg gcg ccc acc ccg gcg ccc gcc tcc tcc tcc tcc tgc tgc ggc      207
 Ala Pro Ala Pro Thr Pro Ala Pro Ala Ser Ser Ser Ser Cys Cys Gly
                  30                  35                  40

 tcc ggc agg ggc tgc tgc ggc gac tca ggc tgc tgc ggc tcc agc tcc      255
 Ser Gly Arg Gly Cys Cys Gly Asp Ser Gly Cys Cys Gly Ser Ser Ser
              45                  50                  55

 acc agt tgc tgc tgc ttc cca agg aga cgc cgt cga cag cgg agt agt      303
 Thr Ser Cys Cys Cys Phe Pro Arg Arg Arg Arg Arg Gln Arg Ser Ser
          60                  65                  70

 ggt tgc tgc tgc tgc ggg ggc ggc agc cag agg tcc cag cgc tcc aac      351
 Gly Cys Cys Cys Cys Gly Gly Gly Ser Gln Arg Ser Gln Arg Ser Asn
      75                  80                  85

 aac cgg agc tca gga tgc tgc tcc ggc tgc tga gaggcccg caacccccag      402
 Asn Arg Ser Ser Gly Cys Cys Ser Gly Cys 
  90                  95

 cgctgcgcta gagaaacccg cccagcccag agcgggcccg ccccgctgcg gctcccacgc    462

 ggggctgggc ctcggagttt gccccgtaaa gcgaattgca ctttgatgtt cagaaaccca    522

 ctttgttctc agccacgcaa aactccctga ccccgatgtg atttttctcc ccggggattc    582

 gagagccatg cgtgggacac tggaccctac tgtctacacg ggcttgcaca cagcaggtgc    642

 tcagcaaatg tctattgatt tgattgtctt ttgaagatgt cataataaag cttctacctc    702

 ctgaaaaaaa aaaaaaaa                                                  720




      <210> 384
      <211> 1891
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(1635)

      <400> 384
 actcttcgtc atcacctctc ctattcgcct ggacaagctc atgtttgcag gagcacc        57                                                                 
 atg tct tgc tcg tct cgc gcc tcc tcc tcc agg gct gga ggc agc agc      105
 Met Ser Cys Ser Ser Arg Ala Ser Ser Ser Arg Ala Gly Gly Ser Ser
   1               5                  10                  15

 tca gcc agg gtg tct gct ggt gga agc agc ttc agc agt gga agc aga      153
 Ser Ala Arg Val Ser Ala Gly Gly Ser Ser Phe Ser Ser Gly Ser Arg
              20                  25                  30

 tgt ggt ctg ggg ggc agc tcg gcc cag ggc ttc cga gga gga gcc agc      201
 Cys Gly Leu Gly Gly Ser Ser Ala Gln Gly Phe Arg Gly Gly Ala Ser
          35                  40                  45

 agc tgc agc ctg agt ggg ggg tct agc gat gct ttt ggg ggc agc ttt      249
 Ser Cys Ser Leu Ser Gly Gly Ser Ser Asp Ala Phe Gly Gly Ser Phe
      50                  55                  60

 gga ggg ggc ttt ggt agc tgc tca gta ggg ggt ggt ttt ggg gga gct      297
 Gly Gly Gly Phe Gly Ser Cys Ser Val Gly Gly Gly Phe Gly Gly Ala
  65                  70                  75                  80

 tca ggc tct ggg aca gga ttt ggt ggg ggt tct agc ttt ggc ggg gtc      345
 Ser Gly Ser Gly Thr Gly Phe Gly Gly Gly Ser Ser Phe Gly Gly Val
                  85                  90                  95

 tct gga ttt ggc agg ggt tct gga ttc tgt ggg agt tct aga ttc agc      393
 Ser Gly Phe Gly Arg Gly Ser Gly Phe Cys Gly Ser Ser Arg Phe Ser
             100                 105                 110

 agt ggt gct act gga ggc ttc tac agc tat ggt ggt ggt atg gga ggt      441
 Ser Gly Ala Thr Gly Gly Phe Tyr Ser Tyr Gly Gly Gly Met Gly Gly
         115                 120                 125

 ggt gtt ggc gat ggg ggg ctt ttc tct gga ggg gaa aag caa acc atg      489
 Gly Val Gly Asp Gly Gly Leu Phe Ser Gly Gly Glu Lys Gln Thr Met
     130                 135                 140

 cag aac ctc aat gac cgc ttg gcc aat tac cta gac aag gtc aga gcc      537
 Gln Asn Leu Asn Asp Arg Leu Ala Asn Tyr Leu Asp Lys Val Arg Ala
 145                 150                 155                 160

 ctg gag gag gct aac act gat ctg gag aac aaa atc aag gag tgg tat      585
 Leu Glu Glu Ala Asn Thr Asp Leu Glu Asn Lys Ile Lys Glu Trp Tyr
                 165                 170                 175

 gac aaa tat ggg cct ggg tct gga gac ggt gga tcg gga aga gat tat      633
 Asp Lys Tyr Gly Pro Gly Ser Gly Asp Gly Gly Ser Gly Arg Asp Tyr
             180                 185                 190

 agc aaa tac tat tca ata att gaa gat ctc aga aac cag atc att gct      681
 Ser Lys Tyr Tyr Ser Ile Ile Glu Asp Leu Arg Asn Gln Ile Ile Ala
         195                 200                 205

 gcc act gtt gaa aat gct ggg atc att ttg cac att gac aat gcc aga      729
 Ala Thr Val Glu Asn Ala Gly Ile Ile Leu His Ile Asp Asn Ala Arg
     210                 215                 220

 ttg gct gct gat gac ttc aga ctg aag tat gag aac gag ctg tgt ctc      777
 Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu Cys Leu
 225                 230                 235                 240

 cgg cag agc gtg gag gct gac atc aat ggc ctg cgg aaa gtc ctg gat      825
 Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Lys Val Leu Asp
                 245                 250                 255

 gac ctg act atg acc cgc tct gac ctg gag atg cag att gag agt ttc      873
 Asp Leu Thr Met Thr Arg Ser Asp Leu Glu Met Gln Ile Glu Ser Phe
             260                 265                 270

 acc gag gag cta gcc tac ctg agg aag aac cac gag gag gaa atg aag      921
 Thr Glu Glu Leu Ala Tyr Leu Arg Lys Asn His Glu Glu Glu Met Lys
         275                 280                 285

 aat atg caa gga agc tct gga ggg gag gtg acc gta gaa atg aat gct      969
 Asn Met Gln Gly Ser Ser Gly Gly Glu Val Thr Val Glu Met Asn Ala
     290                 295                 300

 gcg cca ggg acc gac ctg acc aaa tta ctg aat gac atg agg gcg cag     1017
 Ala Pro Gly Thr Asp Leu Thr Lys Leu Leu Asn Asp Met Arg Ala Gln
 305                 310                 315                 320

 tac gag gag ctg gct gag caa aac cgc cga gag gct gag gag cgg ttc     1065
 Tyr Glu Glu Leu Ala Glu Gln Asn Arg Arg Glu Ala Glu Glu Arg Phe
                 325                 330                 335

 aac aag cag agc gca tca cta caa gca caa atc tcc act gat gct ggg     1113
 Asn Lys Gln Ser Ala Ser Leu Gln Ala Gln Ile Ser Thr Asp Ala Gly
             340                 345                 350

 gca gcc act tct gcc aag aat gag ata aca gaa cta aaa cgt acc ctg     1161
 Ala Ala Thr Ser Ala Lys Asn Glu Ile Thr Glu Leu Lys Arg Thr Leu
         355                 360                 365

 caa gcc ctg gaa att gag ctt cag tcc caa ctg gcc atg aaa agc tcc     1209
 Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala Met Lys Ser Ser
     370                 375                 380

 ctg gag gga acc ctg gct gac aca gaa gct ggc tac gtg gct cag ctg     1257
 Leu Glu Gly Thr Leu Ala Asp Thr Glu Ala Gly Tyr Val Ala Gln Leu
 385                 390                 395                 400

 tca gaa att caa acg cag atc agt gcc ctg gag gag gag atc tgc cag     1305
 Ser Glu Ile Gln Thr Gln Ile Ser Ala Leu Glu Glu Glu Ile Cys Gln
                 405                 410                 415

 atc tgg ggt gag act aaa tgc cag aac gca gag tac aag caa ttg ctg     1353
 Ile Trp Gly Glu Thr Lys Cys Gln Asn Ala Glu Tyr Lys Gln Leu Leu
             420                 425                 430

 gac atc aag aca cgc ctg gag gtg gag atc gag acc tac cgc cgc ctg     1401
 Asp Ile Lys Thr Arg Leu Glu Val Glu Ile Glu Thr Tyr Arg Arg Leu
         435                 440                 445

 ctc gat gga gag gga ggt ggt tct agt ttt gca gaa ttt ggt ggt aga     1449
 Leu Asp Gly Glu Gly Gly Gly Ser Ser Phe Ala Glu Phe Gly Gly Arg
     450                 455                 460

 aac tca gga tct gta aac atg gga tcc agg gat ctg gta tct ggt gac     1497
 Asn Ser Gly Ser Val Asn Met Gly Ser Arg Asp Leu Val Ser Gly Asp
 465                 470                 475                 480

 tca aga tct gga agc tgt tct ggt caa gga cga gat tca agc aag act     1545
 Ser Arg Ser Gly Ser Cys Ser Gly Gln Gly Arg Asp Ser Ser Lys Thr
                 485                 490                 495

 aga gtg act aag act atc gta gag gag ttg gtg gat ggc aag gtt gtc     1593
 Arg Val Thr Lys Thr Ile Val Glu Glu Leu Val Asp Gly Lys Val Val
             500                 505                 510

 tcg tct caa gtc agc agt att tct gag gtg aaa gtt aaa taa ggaactt     1642
 Ser Ser Gln Val Ser Ser Ile Ser Glu Val Lys Val Lys 
         515                 520                 525

 ccagatcaac aaaagtgtct ttcaaagaaa aaaaaatcaa gaaggacaca agcgaagaaa   1702

 tggcatcaat ctaggcatct ttctggataa tttcaggaaa agcttcagtc cagaaatgga   1762

 tgactagcca acttttctgc atcttcttat ttcctcatta gaatgctctt gaaatagctg   1822

 aattaacaac tttgctttaa ttgtttctat gcttcaataa atttactttt gcaagttaaa   1882

 aaaaaaaaa                                                           1891




      <210> 385
      <211> 740
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(476)

      <400> 385
 ttccgggtcg acccacgcgt ccggtgcaga gttccttggg gacattatgg ccactcctgt     60

 ccagatgaga gggagccggc tgcctgtgac agcgtcgcaa a    atg ccg cca ggg     113
                                                  Met Pro Pro Gly
                                                    1

 ctt tcc ctc cct cct cct ttc tct ctt cct cgt ccc tct ctg gtt ggt      161
 Leu Ser Leu Pro Pro Pro Phe Ser Leu Pro Arg Pro Ser Leu Val Gly
   5                  10                  15                  20

 ggt ttc ctg cag gct ccc gtc cct gct ggt gct ggc cac aat gtc ccc      209
 Gly Phe Leu Gln Ala Pro Val Pro Ala Gly Ala Gly His Asn Val Pro
                  25                  30                  35

 act ccc agg gtt tcg gcg tcc cag ccc cct gcg ccc acc gcg cct gcc      257
 Thr Pro Arg Val Ser Ala Ser Gln Pro Pro Ala Pro Thr Ala Pro Ala
              40                  45                  50

 cgc cag aat ccc tgt gcc ctt ggt gcg tgt ggc ctg ccg agc ctc gag      305
 Arg Gln Asn Pro Cys Ala Leu Gly Ala Cys Gly Leu Pro Ser Leu Glu
          55                  60                  65

 ccc ctg ttc tcc tca gcc ctc ttt cct ccc gcg tcc cca gga ggt gcc      353
 Pro Leu Phe Ser Ser Ala Leu Phe Pro Pro Ala Ser Pro Gly Gly Ala
      70                  75                  80

 tct gga agc cac gga gtc cca tcg gca cca aga ccg act gcc ctt tgg      401
 Ser Gly Ser His Gly Val Pro Ser Ala Pro Arg Pro Thr Ala Leu Trp
  85                  90                  95                 100

 ggt gag gta gta ggt tgt ata gtt tgg ggc tct gcc ctg cta tgg gat      449
 Gly Glu Val Val Gly Cys Ile Val Trp Gly Ser Ala Leu Leu Trp Asp
                 105                 110                 115

 aac tat aca atc tac tgt ctt tcc tga agtgg ctgtaatatc tgcggtggac      501
 Asn Tyr Thr Ile Tyr Cys Leu Ser 
             120

 agagcgtctg gaaccctggc tgggagcggg cagggccagg tttgggggca accttggcag    561

 cagtcggggg caggggccgc ctacactgaa aagtctgaca ggcctaggtg ccacttgctg    621

 tgtgaccttg gacaggcccc tgatctctct gggtctcagt ttcctcctct gtaaaatgga    681

 ggcaaatgat gatggaagga gatgcactgt ggagcatcga aggcagagga gagctgacc     740




      <210> 386
      <211> 2314
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(1491)

      <400> 386
 acttggtctg gggctggcca c  atg gag ccc ggg ctg gag cac gca ctg cgc      51
                          Met Glu Pro Gly Leu Glu His Ala Leu Arg
                            1               5                  10

 agg acc cct tcc tgg agc agc ctt ggg ggt tct gag cat caa gag atg       99
 Arg Thr Pro Ser Trp Ser Ser Leu Gly Gly Ser Glu His Gln Glu Met
                  15                  20                  25

 agc ttc cta gag caa gaa aac agc agc tca tgg cca tca cca gct gtg      147
 Ser Phe Leu Glu Gln Glu Asn Ser Ser Ser Trp Pro Ser Pro Ala Val
              30                  35                  40

 acc agc agc tca gaa aga atc cgt ggg aaa cgg agg gcc aaa gcc ttg      195
 Thr Ser Ser Ser Glu Arg Ile Arg Gly Lys Arg Arg Ala Lys Ala Leu
          45                  50                  55

 aga tgg aca agg cag aag tcg gtg gag gaa ggg gag cca cca ggt cag      243
 Arg Trp Thr Arg Gln Lys Ser Val Glu Glu Gly Glu Pro Pro Gly Gln
      60                  65                  70

 ggg gaa ggt ccc cgg tcc agg cca gct gct gag tcc acc ggg ctg gag      291
 Gly Glu Gly Pro Arg Ser Arg Pro Ala Ala Glu Ser Thr Gly Leu Glu
  75                  80                  85                  90

 gcc aca ttc ccc aag acc aca ccc ttg gct caa gct gat cct gcc ggg      339
 Ala Thr Phe Pro Lys Thr Thr Pro Leu Ala Gln Ala Asp Pro Ala Gly
                  95                 100                 105

 gtg ggc act cca cca aca ggg tgg gac tgc ctc ccc tct gac tgt aca      387
 Val Gly Thr Pro Pro Thr Gly Trp Asp Cys Leu Pro Ser Asp Cys Thr
             110                 115                 120

 gcc tca gct gca ggc tcc agc aca gat gat gtg gag ctg gcc acg gag      435
 Ala Ser Ala Ala Gly Ser Ser Thr Asp Asp Val Glu Leu Ala Thr Glu
         125                 130                 135

 ttc cca gcc aca gag gcc tgg gag tgt gag cta gaa ggc ctg ctg gaa      483
 Phe Pro Ala Thr Glu Ala Trp Glu Cys Glu Leu Glu Gly Leu Leu Glu
     140                 145                 150

 gag agg cct gcc ctg tgc ctg tcc ccg cag gcc cca ttt ccc aag ctg      531
 Glu Arg Pro Ala Leu Cys Leu Ser Pro Gln Ala Pro Phe Pro Lys Leu
 155                 160                 165                 170

 ggc tgg gat gac gaa ctg cgg aaa ccc ggc gcc cag atc tac atg cgc      579
 Gly Trp Asp Asp Glu Leu Arg Lys Pro Gly Ala Gln Ile Tyr Met Arg
                 175                 180                 185

 ttc atc gag gag cac acc tgc tac gat gcc atg gca act agc tcc aag      627
 Phe Ile Glu Glu His Thr Cys Tyr Asp Ala Met Ala Thr Ser Ser Lys
             190                 195                 200

 cta gtc atc ttc gac acc atg ctg gag atc aag aag gcc ttc ttt gct      675
 Leu Val Ile Phe Asp Thr Met Leu Glu Ile Lys Lys Ala Phe Phe Ala
         205                 210                 215

 ctg gtg gcc aac ggt gtg cgg gca gcc cct cta tgg gac agc aag aag      723
 Leu Val Ala Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys
     220                 225                 230

 cag agc ttt gtg ggg atg ctg acc atc act gac ttc atc ctg gtg ctg      771
 Gln Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Leu Val Leu
 235                 240                 245                 250

 cat cgc tac tac agg tcc ccc ctg gtc cag atc tat gag att gaa caa      819
 His Arg Tyr Tyr Arg Ser Pro Leu Val Gln Ile Tyr Glu Ile Glu Gln
                 255                 260                 265

 cat aag att gag acc tgg agg gag atc tac ctg caa ggc tgc ttc aag      867
 His Lys Ile Glu Thr Trp Arg Glu Ile Tyr Leu Gln Gly Cys Phe Lys
             270                 275                 280

 cct ctg gtc tcc atc tct cct aat gat agc ctg ttt gaa gct gtc tac      915
 Pro Leu Val Ser Ile Ser Pro Asn Asp Ser Leu Phe Glu Ala Val Tyr
         285                 290                 295

 acc ctc atc aag aac cgg atc cat cgc ctg cct gtt ctt gac ccg gtg      963
 Thr Leu Ile Lys Asn Arg Ile His Arg Leu Pro Val Leu Asp Pro Val
     300                 305                 310

 tca ggc aac gta ctc cac atc ctc aca cac aaa cgc ctg ctc aag ttc     1011
 Ser Gly Asn Val Leu His Ile Leu Thr His Lys Arg Leu Leu Lys Phe
 315                 320                 325                 330

 ctg cac atc ttt ggt tcc ctg ctg ccc cgg ccc tcc ttc ctc tac cgc     1059
 Leu His Ile Phe Gly Ser Leu Leu Pro Arg Pro Ser Phe Leu Tyr Arg
                 335                 340                 345

 act atc caa gat ttg ggc atc ggc aca ttc cga gac ttg gct gtg gtg     1107
 Thr Ile Gln Asp Leu Gly Ile Gly Thr Phe Arg Asp Leu Ala Val Val
             350                 355                 360

 ctg gag aca gca ccc atc ctg act gca ctg gac atc ttt gtg gac cgg     1155
 Leu Glu Thr Ala Pro Ile Leu Thr Ala Leu Asp Ile Phe Val Asp Arg
         365                 370                 375

 cgt gtg tct gca ctg cct gtg gtc aac gaa tgt ggt cag gtc gtg ggc     1203
 Arg Val Ser Ala Leu Pro Val Val Asn Glu Cys Gly Gln Val Val Gly
     380                 385                 390

 ctc tat tcc cgc ttt gat gtg att cac ctg gct gcc cag caa acc tac     1251
 Leu Tyr Ser Arg Phe Asp Val Ile His Leu Ala Ala Gln Gln Thr Tyr
 395                 400                 405                 410

 aac cac ctg gac atg agt gtg gga gaa gcc ctg agg cag agg aca cta     1299
 Asn His Leu Asp Met Ser Val Gly Glu Ala Leu Arg Gln Arg Thr Leu
                 415                 420                 425

 tgt ctg gag gga gtc ctt tcc tgc cag ccc cac gag agc ttg ggg gaa     1347
 Cys Leu Glu Gly Val Leu Ser Cys Gln Pro His Glu Ser Leu Gly Glu
             430                 435                 440

 gtg atc gac agg att gct cgg gag cag gta cac agg ctg gtg cta gtg     1395
 Val Ile Asp Arg Ile Ala Arg Glu Gln Val His Arg Leu Val Leu Val
         445                 450                 455

 gac gag acc cag cat ctc ttg ggc gtg gtc tcc ctc tcc gac atc ctt     1443
 Asp Glu Thr Gln His Leu Leu Gly Val Val Ser Leu Ser Asp Ile Leu
     460                 465                 470

 cag gca ctg gtg ctc agc cct gct ggc atc gat gcc ctc ggg gcc tga     1491
 Gln Ala Leu Val Leu Ser Pro Ala Gly Ile Asp Ala Leu Gly Ala 
 475                 480                 485

 gaagatctga gtcctcaatc ccaagccacc tgcacacctg gaagccaatg aagggaactg   1551

 gagaactcag ccttcatctt cccccacccc catttgctgg ttcagctatg attcaggctt   1611

 cttcagccct cccaaattgc ccttgcccta cctgtgctcc cagaagccct cgggcatgcc   1671

 cagtgcacca tgggatgatg aaattaagga gaacagctga gtcaagcttg gaggtccctg   1731

 aaccagaggc actaggatta ccccagggcc atctgtgctc catgcccgcc catccccttg   1791

 ccgcctgact gggtcggatg gccccagtgg gtttagtcag ggcttctgga ttcctcggtt   1851

 tctgggctac ctatggcttc agccttcagc tcctgggagt cccagctgtt gttcccagca   1911

 acgtcgccac tgccctccta ctctccaggc tttgtcattt caaggctgct gaaatgctgc   1971

 atttcagggg ccaccatgga gcagccgtta tttatagaac tgcctgttgg aggtggggag   2031

 tcctccctcc attcttgtcc agaaaactcc ttagctctcg cagtgagcca tgttcttagt   2091

 ctccagggat ggatggcctt gtatatggac ccctgagaat gagcaattga gaaaacaaaa   2151

 caaaaggaac aatccatgaa cttagatttt attggtttca ctcaaaatgc tgcagtcatt   2211

 tgacctgaac ttgtggcaag agacttgtgc tttctaaatt caaagactag aaggaaaatg   2271

 gataaaaatc acaagtgccg tttctcttgc aaaaaaaaaa aaa                     2314




      <210> 387
      <211> 678
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(393)

      <400> 387
 ctgaggtgct gaaggaccct gtgctgcctg tgacctcgct cctgaacacc caccgccgag     60
                                                                 
 atg tcc tgc cag cag agc cag cag cag tgc cag ccc cct ccc aag tgc      108
 Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys
   1               5                  10                  15

 acc ccc aag tgc cct ccc aag tgc ccc act cct aag tgc ccc cca aag      156
 Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys
              20                  25                  30

 tgt ccc cct aag tgc cct cca gtc tct tcc tgc tgc agt gtc agc tcc      204
 Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser
          35                  40                  45

 gga ggc tgc tgt ggc tcc agc tct ggg ggc ggc tgc agc tct ggg gga      252
 Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Gly Cys Ser Ser Gly Gly
      50                  55                  60

 ggt ggc tgc tgc ctg agc cac cac agg cgc cac agg tcc cac cgt cac      300
 Gly Gly Cys Cys Leu Ser His His Arg Arg His Arg Ser His Arg His
  65                  70                  75                  80

 aga ctc cag agc tct ggc tgc tgc agc cag ccc tcg gga ggc tcc agc      348
 Arg Leu Gln Ser Ser Gly Cys Cys Ser Gln Pro Ser Gly Gly Ser Ser
                  85                  90                  95

 tgc tgt gga ggg gac agc ggc cag cac tct gga ggc tgc tgc tga agc      396
 Cys Cys Gly Gly Asp Ser Gly Gln His Ser Gly Gly Cys Cys 
             100                 105                 110

 ggactctgca cctagaagag cagactcggg tgaaatgagt gatcaaacat ttcctcctca    456

 cctgtctcct cctgggcctg caagagtggc tgagatgccc gcgtgaaggc tctgagctct    516

 ggcctagagg atccctctgc cctgggatcc agaaacttga ttcttctccc acaaacctat    576

 ctgctgcccc tgacaccaac tgtgttgtct actctgggat cccaagccac aaactcactc    636

 acgaaatcgt cgacagcgaa gtcgacccgg gaattccgga cc                       678




      <210> 388
      <211> 1036
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(651)

      <400> 388
 cggacgcgtg ggctgctcct ctacctgctc caccctcaac ccaccaaaac c atg ggc      57
                                                          Met Gly
                                                            1

 tgc tct ggc tgc tct gga ggc tgt ggc tcc agc tgt ggg ggc tgt ggc      105
 Cys Ser Gly Cys Ser Gly Gly Cys Gly Ser Ser Cys Gly Gly Cys Gly
           5                  10                  15

 tcc agc tgt ggg ggc tgt ggc tcc ggc tat ggg ggc tgt ggc tcc ggc      153
 Ser Ser Cys Gly Gly Cys Gly Ser Gly Tyr Gly Gly Cys Gly Ser Gly
      20                  25                  30

 tgc tgt gta cct gtc tgc tgc tgc aag ccc gtg tgc tgc tgt gtg cca      201
 Cys Cys Val Pro Val Cys Cys Cys Lys Pro Val Cys Cys Cys Val Pro
  35                  40                  45                  50

 gcc tgt tcc tgc tcc agc tgt ggc tcc tgt ggg ggc tcc aag ggg gtc      249
 Ala Cys Ser Cys Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys Gly Val
                  55                  60                  65

 tgt ggc tct tgt ggg ggc tgc aag ggg ggc tgt ggc tcc tgt gga ggc      297
 Cys Gly Ser Cys Gly Gly Cys Lys Gly Gly Cys Gly Ser Cys Gly Gly
              70                  75                  80

 tcc aag ggg ggc tgt ggc tcc agc tgc tgt gtg ccc gtc tgc tgc tcc      345
 Ser Lys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Val Cys Cys Ser
          85                  90                  95

 tcc agc tgt ggc tcc tgt ggg ggt tcc aag ggg gtc tgt gga ttt cgt      393
 Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys Gly Val Cys Gly Phe Arg
     100                 105                 110

 ggg ggc tcc aag ggg ggc tgc ggt tct tat ggc tgc tcc cag tcc agc      441
 Gly Gly Ser Lys Gly Gly Cys Gly Ser Tyr Gly Cys Ser Gln Ser Ser
 115                 120                 125                 130

 tgc tgc aag ccc tgc tgc tgc tcc tca ggc tgt ggg tca tcc tgc tgc      489
 Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys
                 135                 140                 145

 cag tcc agc tgc tgt aag ccc tac tgc tgc cag tcc agc tgc tgt aag      537
 Gln Ser Ser Cys Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys Cys Lys
             150                 155                 160

 ccc tgt agc tgc ttc tca ggc tgt gga tca tcc tgc tgc caa tcc agc      585
 Pro Cys Ser Cys Phe Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser Ser
         165                 170                 175

 tgc tac aag ccc tgc tgc tgc cag tcc agc tgc tgt gtc ccc gtg tgc      633
 Cys Tyr Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys Val Pro Val Cys
     180                 185                 190

 tgc cag tgt aag atc tga ggctct gactgcagac tgcaggtggc ctgactggtg      687
 Cys Gln Cys Lys Ile 
 195

 aagggcccgg ctgcccagct tccttgccct gggttctctg gtgctccact gtctccactg    747

 tgtcctcact ggcttcatcc actccacacc agtgctcccg aaactgactg aggacccctt    807

 ctggctcatt gcctactact tctcctgaac ttcctctccc tgctcctcac tcatttaaga    867

 tccaaagcgg cccactgagg ccccagaggc agatcagacc ccttagaccc tgacagctgc    927

 tccttctttc aggagtgtga tcgaccctca atctctctgg ctgtctgtat atcaagactg    987

 aatcctgacc ctctaaataa acaaagtctc taagcacaaa aaaaaaaaa               1036




      <210> 389
      <211> 778
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(328)

      <220>
      <221> misc_feature
      <222> (1)...(778)
      <223> n = a,t,c or g

      <400> 389
 caatagcgac cggntttgaa ttcccgggtc gagnnangng tncgctgggg gccagcttgt     60

 cgcctctggc tcacctgttc ctagagca   atg tct tcc cag cag cag cag cgg     112
                                  Met Ser Ser Gln Gln Gln Gln Arg
                                    1               5

 cag cag cag cag tgc cca ccc cag agg gcc cag cag cag caa gtg aag      160
 Gln Gln Gln Gln Cys Pro Pro Gln Arg Ala Gln Gln Gln Gln Val Lys
      10                  15                  20

 cag cct tgt cag cca ccc cct gtt aaa tgt caa gag aca tgt gca ccc      208
 Gln Pro Cys Gln Pro Pro Pro Val Lys Cys Gln Glu Thr Cys Ala Pro
  25                  30                  35                  40

 aaa acc aag gat cca tgt gct ccc cag gtc aag aag caa tgc cca ccg      256
 Lys Thr Lys Asp Pro Cys Ala Pro Gln Val Lys Lys Gln Cys Pro Pro
                  45                  50                  55

 aaa ggc acc atc att cca gcc cag cag aag tgt ccc tca gcc cag caa      304
 Lys Gly Thr Ile Ile Pro Ala Gln Gln Lys Cys Pro Ser Ala Gln Gln
              60                  65                  70

 gcc tcc aag agt aaa cag aag taa ggatggactg gatattacca tcatccacca     358
 Ala Ser Lys Ser Lys Gln Lys 
          75

 tcctggctac cagatggaac tttctcttct tccttctcct cttccctcca gctcttgagc    418

 ctaccctcct ctcacatctc ctcctgccca agatgtaagg aagcattgta aggatttctt    478

 cccatcgtac ccttccccac acataccacc ttggcttctt ctatatccca ccccgatgct    538

 ctcccaggtg ggtgtgagag agacctcatt ctctgcaggc tccagcgtgg ccacagctaa    598

 ggcccatcca tttcccaaag tgaggaaagt gtctgggctt cttctggggt tccaccctga    658

 caagtagggt cacagaggct ggtgcacagt ttctgcctca ttcctctcca tgatgccccc    718

 tgctctgggc ttctctcctg ttttccccaa taaatatgtg cctcatgtaa aaaaaaaaaa    778




      <210> 390
      <211> 2112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(1721)

      <400> 390
 cgtaccggtc cggaaatccc gcctcgaccc acgcgtccgg gcaactcagg caagggtcag     60

 gactgaaggg gtggcgggcc ggaacatggg tggaatgcct gtgctcagtt atccccgcac    120

 ctctccaccc acacccgcag cccccacccg ggccacccac tctcccttgg ccacacctgc    180

 cgggtgccac g atg acc gtc acc tac aca gcc cga gtg gcg aac gcc cgc     230
              Met Thr Val Thr Tyr Thr Ala Arg Val Ala Asn Ala Arg
                1               5                  10

 ttc ggt ggc ttc tcc cag ctg ctg cta ctg tgg cgt ggg agc atc tac      278
 Phe Gly Gly Phe Ser Gln Leu Leu Leu Leu Trp Arg Gly Ser Ile Tyr
      15                  20                  25

 aaa ctc ctg tgg cga gag ctg ctc tgc ttc ctt ggg ttc tac atg gcg      326
 Lys Leu Leu Trp Arg Glu Leu Leu Cys Phe Leu Gly Phe Tyr Met Ala
  30                  35                  40                  45

 ctg agt gct gcc tac cgc ttt gtg ctg acc gaa ggg cag aag cgc tac      374
 Leu Ser Ala Ala Tyr Arg Phe Val Leu Thr Glu Gly Gln Lys Arg Tyr
                  50                  55                  60

 ttc gag aag ctt gtg att tat tgt gac cag tat gcc agc ctc atc cct      422
 Phe Glu Lys Leu Val Ile Tyr Cys Asp Gln Tyr Ala Ser Leu Ile Pro
              65                  70                  75

 gtc tcc ttc gtg ctt ggc ttt tat gtg acg ctg gtg gtg aac cgc tgg      470
 Val Ser Phe Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp
          80                  85                  90

 tgg agc cag tac cta tgc atg ccg ctg ccc gac gcg ctc atg tgc gtg      518
 Trp Ser Gln Tyr Leu Cys Met Pro Leu Pro Asp Ala Leu Met Cys Val
      95                 100                 105

 gtg gcg ggc acc gtg cac gga cgc gac gac cgc ggc cgc ctc tac cgg      566
 Val Ala Gly Thr Val His Gly Arg Asp Asp Arg Gly Arg Leu Tyr Arg
 110                 115                 120                 125

 cgc aca ctc atg cgc tac gca ggg ctc tcg gcc gtg ctc atc ctg cgc      614
 Arg Thr Leu Met Arg Tyr Ala Gly Leu Ser Ala Val Leu Ile Leu Arg
                 130                 135                 140

 tcc gtc agc acc gcg gtg ttc aag cgc ttc ccc acc ata gac cac gtg      662
 Ser Val Ser Thr Ala Val Phe Lys Arg Phe Pro Thr Ile Asp His Val
             145                 150                 155

 gtg gag gct ggg ttt atg acc cgc gag gag cgc aag aag ttt gaa aac      710
 Val Glu Ala Gly Phe Met Thr Arg Glu Glu Arg Lys Lys Phe Glu Asn
         160                 165                 170

 ctg aac tca tcc tac aac aag tac tgg gtg ccc tgc gtc tgg ttc tcc      758
 Leu Asn Ser Ser Tyr Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Ser
     175                 180                 185

 aac ctg gcg gca cag gcc cga cgc gag ggc cgc atc cgc gac aac agc      806
 Asn Leu Ala Ala Gln Ala Arg Arg Glu Gly Arg Ile Arg Asp Asn Ser
 190                 195                 200                 205

 gcc ctt aag ctg ctg ctc gag gag ctg aat gtt ttt cgg ggc aaa tgt      854
 Ala Leu Lys Leu Leu Leu Glu Glu Leu Asn Val Phe Arg Gly Lys Cys
                 210                 215                 220

 gga atg ctc ttt cac tat gac tgg att agc gta ccc ctc gtg tac acg      902
 Gly Met Leu Phe His Tyr Asp Trp Ile Ser Val Pro Leu Val Tyr Thr
             225                 230                 235

 cag gtg gtg acc atc gca ctg tac agc tac ttc ctg gct tgc ctc att      950
 Gln Val Val Thr Ile Ala Leu Tyr Ser Tyr Phe Leu Ala Cys Leu Ile
         240                 245                 250

 ggt cgc cag ttc ctg gac ccg gct cag ggt tac aaa gac cac gac cta      998
 Gly Arg Gln Phe Leu Asp Pro Ala Gln Gly Tyr Lys Asp His Asp Leu
     255                 260                 265

 gac ctg tgt gtg ccc atc ttc acc ctc ttg cag ttc ttc ttc tac gcc     1046
 Asp Leu Cys Val Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala
 270                 275                 280                 285

 ggc tgg ctc aag gta gct gag cag ctc atc aac ccc ttc gga gag gac     1094
 Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp
                 290                 295                 300

 gat gat gac ttt gag acc aac ttt ctg atc gat aga aac ttc cag gtg     1142
 Asp Asp Asp Phe Glu Thr Asn Phe Leu Ile Asp Arg Asn Phe Gln Val
             305                 310                 315

 tcc atg ctg gca gtg gac gag atg tat gat gac ctg gct gtg ctg gag     1190
 Ser Met Leu Ala Val Asp Glu Met Tyr Asp Asp Leu Ala Val Leu Glu
         320                 325                 330

 aag gac ttg tac tgg gat gca gcc gag gct cgc gcc cca tac aca gcg     1238
 Lys Asp Leu Tyr Trp Asp Ala Ala Glu Ala Arg Ala Pro Tyr Thr Ala
     335                 340                 345

 gct act gtc ttc cag ctg cgg cag cct tcc ttc cag ggc tcc acc ttt     1286
 Ala Thr Val Phe Gln Leu Arg Gln Pro Ser Phe Gln Gly Ser Thr Phe
 350                 355                 360                 365

 gac atc acg ctg gcc aaa gaa gac atg cag ttc cag cgg ctg gac ggc     1334
 Asp Ile Thr Leu Ala Lys Glu Asp Met Gln Phe Gln Arg Leu Asp Gly
                 370                 375                 380

 ttg gat gga ccg atg gga ggg gcg ccc ggc gac ttc ctg cag cgc ctc     1382
 Leu Asp Gly Pro Met Gly Gly Ala Pro Gly Asp Phe Leu Gln Arg Leu
             385                 390                 395

 ctg ccg gcg ggc gcg ggc atg gtc gcg gga ggc ccg ctg ggg cgg cgc     1430
 Leu Pro Ala Gly Ala Gly Met Val Ala Gly Gly Pro Leu Gly Arg Arg
         400                 405                 410

 ctg tcc ttt cta ctc cgc aag aac agc tgc gtg tcg gag gcg tct act     1478
 Leu Ser Phe Leu Leu Arg Lys Asn Ser Cys Val Ser Glu Ala Ser Thr
     415                 420                 425

 ggg gcc agc tgc tca tgc gcg gtt gtc ccc gaa ggc gcg gcc ccg gag     1526
 Gly Ala Ser Cys Ser Cys Ala Val Val Pro Glu Gly Ala Ala Pro Glu
 430                 435                 440                 445

 tgc agc tgc ggg gac ccg ctg ctc gac ccc ggc ctg ccg gag ccc gag     1574
 Cys Ser Cys Gly Asp Pro Leu Leu Asp Pro Gly Leu Pro Glu Pro Glu
                 450                 455                 460

 gcc ccg ccc cct gcg ggt ccc gaa ccg ctt acc ctc atc cct ggg cct     1622
 Ala Pro Pro Pro Ala Gly Pro Glu Pro Leu Thr Leu Ile Pro Gly Pro
             465                 470                 475

 gtc gag ccc ttc agc atc gtg acc atg ccc ggg ccc cgg ggt ccg gcg     1670
 Val Glu Pro Phe Ser Ile Val Thr Met Pro Gly Pro Arg Gly Pro Ala
         480                 485                 490

 cca ccc tgg ctg ccc agc cct att ggc gag gag gag gag aat ctg gcc     1718
 Pro Pro Trp Leu Pro Ser Pro Ile Gly Glu Glu Glu Glu Asn Leu Ala
     495                 500                 505

 tga gatc ttagagccca gccccctaag gacagggaac caggtccctg cacggcaccc     1775
 


 acgcaggtgt cccggtctgc ataagcctcg tgtgcctttg taaagtccac ctacactttt   1835

 gaccagctct cgctgcccgc atgtgtttgg cgctgtgcta ggggcgggag ttcttccaga   1895

 ctcttggacc agcccgccct gaccaccagc tctacttccc aacccccact gcctgagagg   1955

 tctctatcag tgtcctgcct gaattctttc cttcaagtga agatgtgact gactacctcc   2015

 tcgagttgtc atgaggatga aagaatggca ttaaagcatt tggtatacag taggtgctca   2075

 ataaattgct agtgattttt actcaaaaaa aaaaaaa                            2112




      <210> 391
      <211> 929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(623)

      <400> 391
 aagctggtac gcctgtaggt accggtccgg ttttcccggg tcgacccacg cgtcggagag     60

 aactgcgtgt ttaatctgac aatgaatatg aatcagcttt gaaataggca ggggtttttg    120

 aacaatattt tttctcatta tatgtttcta ccatcgctgt g    atg ccc tat gta     173
                                                  Met Pro Tyr Val
                                                    1

 ttc tcc ttc aaa atg cct caa gag caa gga cag atg ttt caa tac tat      221
 Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met Phe Gln Tyr Tyr
   5                  10                  15                  20

 cca gtt tac atg gtc cta ccc tgg gaa caa cct cag caa aca gtt cca      269
 Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln Gln Thr Val Pro
                  25                  30                  35

 agg tca cct caa caa aca aga cag caa cag tat gag gag cag ata cca      317
 Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu Glu Gln Ile Pro
              40                  45                  50

 ttc tat gct caa ttt gga tac att cca caa cta gca gaa cct gct ata      365
 Phe Tyr Ala Gln Phe Gly Tyr Ile Pro Gln Leu Ala Glu Pro Ala Ile
          55                  60                  65

 tca gga gga cag cag caa cta gct ttt gat ccc caa cta ggc aca gct      413
 Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln Leu Gly Thr Ala
      70                  75                  80

 cct gaa att gct gtg atg tca aca gga gaa gag ata cca tat tta caa      461
 Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile Pro Tyr Leu Gln
  85                  90                  95                 100

 aaa gaa gcg atc aac ttt aga cat gac agt gca gga gtt ttc atg ccc      509
 Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly Val Phe Met Pro
                 105                 110                 115

 tca act tca cca aaa ccc agc aca acc aat gtt ttc act tct gct gta      557
 Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe Thr Ser Ala Val
             120                 125                 130

 gac caa act att acc cca gag ctc cca gaa gag aag gac aag act gac      605
 Asp Gln Thr Ile Thr Pro Glu Leu Pro Glu Glu Lys Asp Lys Thr Asp
         135                 140                 145

 agc cta agg gaa cca taa gaagtt gccctgatca ttcagacatt ttgggaaaaa      659
 Ser Leu Arg Glu Pro 
     150

 gatgtggcca tgccttggat ataattttag gctattagct tcctcaatac tagtatcagt    719

 tctttggaat acatgaaata tcttgactct tctcctaaat ttgtttttac ttatacatgt    779

 tattaaactc tttaaatatg tcatagaaaa taatacaatc atgtaatgag tcttgtctta    839

 caaaattata tgtctcttca aatatcctat cattgtataa tatggaatat aataacacag    899

 aataaagcta gtatcattaa aaaaaaaaaa                                     929




      <210> 392
      <211> 458
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (252)..(443)

      <400> 392
 tattcccggg tcgacccacg cgtccggtgt aaatgccctt ctaggaaatg agctggagcc     60

 acttgcagaa gatattctcc accaaagccc gaatatgaat gctgttattt ctttacagaa    120

 gatcattgaa attcaaagca agtattggaa gtcagtaagg atggtggctg tgccaagggg    180

 ctgtgctctg gctggtgctc agttgcaaga ggagacagag accgtttctg ccctggcctc    240

 cctaacagtg g atg tgg aac agc cct ttg ctc agg aag aca gca gaa ctg     290
              Met Trp Asn Ser Pro Leu Leu Arg Lys Thr Ala Glu Leu
                1               5                  10

 ctg gtg agc cta tgg aag agg agc cag cct tgt gaa gtg cca agt ccc      338
 Leu Val Ser Leu Trp Lys Arg Ser Gln Pro Cys Glu Val Pro Ser Pro
      15                  20                  25

 cct ctg ata ttt cct gtg tgt gac atc att gtg tat ccc ccc acc cca      386
 Pro Leu Ile Phe Pro Val Cys Asp Ile Ile Val Tyr Pro Pro Thr Pro
  30                  35                  40                  45

 gta ccc tca gac atg tct tgt ctg ctg cct ggg tgg cac aga ttc aat      434
 Val Pro Ser Asp Met Ser Cys Leu Leu Pro Gly Trp His Arg Phe Asn
                  50                  55                  60

 gga aca taa acactgggca caaag                                         458
 Gly Thr 






      <210> 393
      <211> 707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(643)

      <400> 393
 ccagagttac ataaagtgtg aggactcagg aggccatgga aggagccaca gctacagcgc     60

 tgacaggctg gagcatggga agccccagtc cacagcctgt gctcagcaca ccccacatgt    120

 ggcctgtgtc cagttggatt ctgtgtcttc tctgtgccat ccatgttctg tatcttcc      178                                                                 
 atg ttc tca gag agc atg att gtg ttc ata tat tct gac cct ccc cca      226
 Met Phe Ser Glu Ser Met Ile Val Phe Ile Tyr Ser Asp Pro Pro Pro
   1               5                  10                  15

 gct cta ccc atc aag ttc aca gag ggt ctg agg aac gaa gag gcc aca      274
 Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala Thr
              20                  25                  30

 gaa ggg gca aca gcc gtg ctg cgg tgt gag ctg agc aag atg gcc ccc      322
 Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu Ser Lys Met Ala Pro
          35                  40                  45

 gtg gag tgg tgg aag ggg cat gag acc ctc aga gat gga gac aga cac      370
 Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His
      50                  55                  60

 agc ctg agg cag gac ggg gcc agg tgt gag ctg cag atc cgc ggc ctc      418
 Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu Gln Ile Arg Gly Leu
  65                  70                  75                  80

 gtg gca gag gac gct ggg gag tac ctg tgc atg tgc ggg aag gag agg      466
 Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met Cys Gly Lys Glu Arg
                  85                  90                  95

 acc tca gcc atg ctc acc gtc agg ggt aaa ggc cac atg cag cca agc      514
 Thr Ser Ala Met Leu Thr Val Arg Gly Lys Gly His Met Gln Pro Ser
             100                 105                 110

 agc acc atg ctc tca tgt cca cgt gtt gac ttg acg cca tcc gtc tct      562
 Ser Thr Met Leu Ser Cys Pro Arg Val Asp Leu Thr Pro Ser Val Ser
         115                 120                 125

 gcc tat gct gcg ttc tct ccc cat gtc tgt gcc tgc ctg tgt aac tgc      610
 Ala Tyr Ala Ala Phe Ser Pro His Val Cys Ala Cys Leu Cys Asn Cys
     130                 135                 140

 acg agc ttc ttc cag cct cca ggg ctg ttg tag gaagcagg agctcagaac      661
 Thr Ser Phe Phe Gln Pro Pro Gly Leu Leu 
 145                 150

 aacgacagcg gccgctgtag aggatccaag cttacgcacg cgtgct                   707




      <210> 394
      <211> 1468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(1253)

      <400> 394
 cctgtggcgc acacccaggg gctcccccg  atg ctg gtt act atc tgg gct atg      53
                                  Met Leu Val Thr Ile Trp Ala Met
                                    1               5

 gtg gcc aca gct gtc ttg ccc ctc ctc acg gcc gtg ctg ggt gtt acc      101
 Val Ala Thr Ala Val Leu Pro Leu Leu Thr Ala Val Leu Gly Val Thr
      10                  15                  20

 gtg gtc acc cgc agg gac acg gag ggg cca ggc aga gca gcc cta gtt      149
 Val Val Thr Arg Arg Asp Thr Glu Gly Pro Gly Arg Ala Ala Leu Val
  25                  30                  35                  40

 cac ctc acc ggg agc ccc cgc cag aag gtg ggc acc tct ggg agg gag      197
 His Leu Thr Gly Ser Pro Arg Gln Lys Val Gly Thr Ser Gly Arg Glu
                  45                  50                  55

 gga ctg cca ggc ctt ggg gct tcc tgt gct gag tca gag ctg gaa cgg      245
 Gly Leu Pro Gly Leu Gly Ala Ser Cys Ala Glu Ser Glu Leu Glu Arg
              60                  65                  70

 gag acg cag gag ccc cgc agc cgc ggg agg tgc aga ttt ggg gct gcc      293
 Glu Thr Gln Glu Pro Arg Ser Arg Gly Arg Cys Arg Phe Gly Ala Ala
          75                  80                  85

 agg tgg cgc cag gtc ccc ttg gcc agc ccc cag cgc ccc ttt ctt ctg      341
 Arg Trp Arg Gln Val Pro Leu Ala Ser Pro Gln Arg Pro Phe Leu Leu
      90                  95                 100

 tcc cca ggg cct cgg ctt cac agg atg ggg ctg cca gtg tcc tgg gcc      389
 Ser Pro Gly Pro Arg Leu His Arg Met Gly Leu Pro Val Ser Trp Ala
 105                 110                 115                 120

 cct cct gcc ctc tgg gtt cta ggg tgc tgc gcc ctg ctc ctc tcg ctg      437
 Pro Pro Ala Leu Trp Val Leu Gly Cys Cys Ala Leu Leu Leu Ser Leu
                 125                 130                 135

 tgg gcg ctg tgc aca gcc tgc cgc agg ccc gag gac gct gta gcc ccc      485
 Trp Ala Leu Cys Thr Ala Cys Arg Arg Pro Glu Asp Ala Val Ala Pro
             140                 145                 150

 agg aag agg gcg cgg agg cag cgg gcg agg ctg cag ggc agt gcg acg      533
 Arg Lys Arg Ala Arg Arg Gln Arg Ala Arg Leu Gln Gly Ser Ala Thr
         155                 160                 165

 gcg gcg gaa gcg tcc cta ctg agg cgg acc cac ctc tgc tcc ctc agc      581
 Ala Ala Glu Ala Ser Leu Leu Arg Arg Thr His Leu Cys Ser Leu Ser
     170                 175                 180

 aag tcg gac acc aga ctg cac gag ctg cac cgg ggc ccg cgc agc agc      629
 Lys Ser Asp Thr Arg Leu His Glu Leu His Arg Gly Pro Arg Ser Ser
 185                 190                 195                 200

 agg gcc ctg cgg cct gcc agc atg gat ctc ctg cgc cca cac tgg ctg      677
 Arg Ala Leu Arg Pro Ala Ser Met Asp Leu Leu Arg Pro His Trp Leu
                 205                 210                 215

 gag gtg tcc agg gac atc acc gga ccg cag gca gcc ccc tct gcc ttc      725
 Glu Val Ser Arg Asp Ile Thr Gly Pro Gln Ala Ala Pro Ser Ala Phe
             220                 225                 230

 cca cac cag gag ctg ccc cgg gct ctg ccg gca gct gca gcc acc gca      773
 Pro His Gln Glu Leu Pro Arg Ala Leu Pro Ala Ala Ala Ala Thr Ala
         235                 240                 245

 ggg tgc gct ggc ctc gag gcc acc tat tcc aac gtg ggg ctg gcg gcc      821
 Gly Cys Ala Gly Leu Glu Ala Thr Tyr Ser Asn Val Gly Leu Ala Ala
     250                 255                 260

 ctt ccc ggg gtc agc ctg gcg gcc agc cct gtg gtg gcc gag tat gcc      869
 Leu Pro Gly Val Ser Leu Ala Ala Ser Pro Val Val Ala Glu Tyr Ala
 265                 270                 275                 280

 cgc gtc cag aag cgc aaa ggg acc cat cgc agt ccc caa gag cca cag      917
 Arg Val Gln Lys Arg Lys Gly Thr His Arg Ser Pro Gln Glu Pro Gln
                 285                 290                 295

 cag ggg aag act gag gtg acc ccg gcc gct cag gtg gac gtc ctg tac      965
 Gln Gly Lys Thr Glu Val Thr Pro Ala Ala Gln Val Asp Val Leu Tyr
             300                 305                 310

 tcc agg gtc tgc aag cct aaa agg agg gac cca gga ccc acc aca gac     1013
 Ser Arg Val Cys Lys Pro Lys Arg Arg Asp Pro Gly Pro Thr Thr Asp
         315                 320                 325

 ccg ctg gac ccc aag ggc cag gga gcg att ctg gcc ctg gcg ggt gac     1061
 Pro Leu Asp Pro Lys Gly Gln Gly Ala Ile Leu Ala Leu Ala Gly Asp
     330                 335                 340

 ctg gcc tac cag acc ctc ccg ctc agg gcc ctg gat gtg gac agc ggc     1109
 Leu Ala Tyr Gln Thr Leu Pro Leu Arg Ala Leu Asp Val Asp Ser Gly
 345                 350                 355                 360

 ccc ctg gaa aac gtg tat gag agc atc cgg gag ctg ggg gac cct gct     1157
 Pro Leu Glu Asn Val Tyr Glu Ser Ile Arg Glu Leu Gly Asp Pro Ala
                 365                 370                 375

 ggc agg agc agc acg tgc ggg gct ggg acg ccc cct gct tcc agc tgc     1205
 Gly Arg Ser Ser Thr Cys Gly Ala Gly Thr Pro Pro Ala Ser Ser Cys
             380                 385                 390

 ccc agc cta ggg agg ggc tgg aga ccc ctc cct gcc tcc ctg ccc tga     1253
 Pro Ser Leu Gly Arg Gly Trp Arg Pro Leu Pro Ala Ser Leu Pro 
         395                 400                 405

 acactcaagg acctgtgctc cttcctccag agtgaggccc gtcccccgcc ccgccccgcc   1313

 tcacagctga cagcgccagt cccaggtccc cgggccgcca gcccgtgagg tccgtgaggt   1373

 cctggccgct ctgacagccg cggcctcccc gggctccaga gaaggcccgc gtctaaataa   1433

 agcgccagcg caggatgaaa gcgaaaaaaa aaaaa                              1468




      <210> 395
      <211> 3526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(3048)

      <400> 395
 gaagattctt tgcctggtgt aattgtgact catgtgtcag ttcatgatgt ggatttgaat     60

 tcagctttca tattcagttt tgccaaagag agtaatcctg gaaccaagtt tgctattgat    120

 cagaacactg gagtggtggt gttggtgaaa acattggatt ttgaagaa atg act gaa     177
                                                      Met Thr Glu
                                                        1

 tat gag ctg ctc atc caa att tct gat tca gtg cac tac aca gag gga      225
 Tyr Glu Leu Leu Ile Gln Ile Ser Asp Ser Val His Tyr Thr Glu Gly
       5                  10                  15

 gca ctt gta gtc cgt gtg ctg gat gtc aat gat aat cca cca gtg ttt      273
 Ala Leu Val Val Arg Val Leu Asp Val Asn Asp Asn Pro Pro Val Phe
  20                  25                  30                  35

 tct caa gat ttc tat cag gtc aca gtt cct gaa tca ata cct gtg ggg      321
 Ser Gln Asp Phe Tyr Gln Val Thr Val Pro Glu Ser Ile Pro Val Gly
                  40                  45                  50

 tat tca gtg ctg act ctg tca gcc aca gac tta gaa agc aat gag aac      369
 Tyr Ser Val Leu Thr Leu Ser Ala Thr Asp Leu Glu Ser Asn Glu Asn
              55                  60                  65

 att tct tac aga att cta tcc tct tct aag gaa ttc tcc att gat cct      417
 Ile Ser Tyr Arg Ile Leu Ser Ser Ser Lys Glu Phe Ser Ile Asp Pro
          70                  75                  80

 aag aat ggc aca ata ttt act atc agt ccc gta tta ctt ctg gat aca      465
 Lys Asn Gly Thr Ile Phe Thr Ile Ser Pro Val Leu Leu Leu Asp Thr
      85                  90                  95

 ata tca aca act cga ttt ctt gtg gaa gcc agt gat ggt gga aat cct      513
 Ile Ser Thr Thr Arg Phe Leu Val Glu Ala Ser Asp Gly Gly Asn Pro
 100                 105                 110                 115

 gac ccg aga gct ctt act tta gtg gag ata gga ata gaa gat atg aac      561
 Asp Pro Arg Ala Leu Thr Leu Val Glu Ile Gly Ile Glu Asp Met Asn
                 120                 125                 130

 aat tat gcc cct gaa ttc aca gtc aaa tcc tat aat ctt agc cta agt      609
 Asn Tyr Ala Pro Glu Phe Thr Val Lys Ser Tyr Asn Leu Ser Leu Ser
             135                 140                 145

 gag gat gct ctg gtt gga agc acg ctt gtt aca ttt tca aac atc gac      657
 Glu Asp Ala Leu Val Gly Ser Thr Leu Val Thr Phe Ser Asn Ile Asp
         150                 155                 160

 cat gac tgg acc cgt gaa aac aca tat gtt gaa tat tcc atc atc agt      705
 His Asp Trp Thr Arg Glu Asn Thr Tyr Val Glu Tyr Ser Ile Ile Ser
     165                 170                 175

 ggt aat tca cag aac aat ttt cat gtg gaa act aag ttc ttt cat tca      753
 Gly Asn Ser Gln Asn Asn Phe His Val Glu Thr Lys Phe Phe His Ser
 180                 185                 190                 195

 gaa tat cct tat aag caa gtc ggt tat ctt gtg ttg ctt cac agt ctg      801
 Glu Tyr Pro Tyr Lys Gln Val Gly Tyr Leu Val Leu Leu His Ser Leu
                 200                 205                 210

 gac aga gaa gca agt gct agc cat gag ctt gtc att ctg gca tct gac      849
 Asp Arg Glu Ala Ser Ala Ser His Glu Leu Val Ile Leu Ala Ser Asp
             215                 220                 225

 agt ggc tgc cct cca ttg agt tcc aca gct gtc ata tca ata caa gta      897
 Ser Gly Cys Pro Pro Leu Ser Ser Thr Ala Val Ile Ser Ile Gln Val
         230                 235                 240

 ctt gat gtc aat gac aat ccc cca aac ttc agc agc ctg agc tat cac      945
 Leu Asp Val Asn Asp Asn Pro Pro Asn Phe Ser Ser Leu Ser Tyr His
     245                 250                 255

 acc cat gtc aag gaa agc acc cct cta ggg agt cac atc act gtg gtc      993
 Thr His Val Lys Glu Ser Thr Pro Leu Gly Ser His Ile Thr Val Val
 260                 265                 270                 275

 tca gca aat gac cgt gac aca ggg tca cat gca gaa atc atc tac aac     1041
 Ser Ala Asn Asp Arg Asp Thr Gly Ser His Ala Glu Ile Ile Tyr Asn
                 280                 285                 290

 atc atc tct gga aat gag aag gga cat ttt tac tta gaa gaa aac act     1089
 Ile Ile Ser Gly Asn Glu Lys Gly His Phe Tyr Leu Glu Glu Asn Thr
             295                 300                 305

 gga gtt ctt tat ttg att aaa cct ctg gat tat gaa aaa atg aca aaa     1137
 Gly Val Leu Tyr Leu Ile Lys Pro Leu Asp Tyr Glu Lys Met Thr Lys
         310                 315                 320

 ttc acc tta act gtc caa gct tca gat gca gaa aag aaa cat ttt tct     1185
 Phe Thr Leu Thr Val Gln Ala Ser Asp Ala Glu Lys Lys His Phe Ser
     325                 330                 335

 ttt gca gtt gtg ttt gtc agt gtc ctg gat gat aac gac cat gca cct     1233
 Phe Ala Val Val Phe Val Ser Val Leu Asp Asp Asn Asp His Ala Pro
 340                 345                 350                 355

 cag ttt atg ttc tca agc ttc agc tgt att gtt cca gaa aat ctg cct     1281
 Gln Phe Met Phe Ser Ser Phe Ser Cys Ile Val Pro Glu Asn Leu Pro
                 360                 365                 370

 att tcc tct acc ata tgc tct ata aat gct ctg gat ttt gat gct ggt     1329
 Ile Ser Ser Thr Ile Cys Ser Ile Asn Ala Leu Asp Phe Asp Ala Gly
             375                 380                 385

 ccg tat gga gaa ttg acc tat tct att gta tca ccc tgt ttt ctc act     1377
 Pro Tyr Gly Glu Leu Thr Tyr Ser Ile Val Ser Pro Cys Phe Leu Thr
         390                 395                 400

 cat gga atg tct tat gat cat gat ctc ttc ctc att gac cct ttg aca     1425
 His Gly Met Ser Tyr Asp His Asp Leu Phe Leu Ile Asp Pro Leu Thr
     405                 410                 415

 ggg gat att cat gct aag caa atc ctt gac tat gaa aat ggc aat aaa     1473
 Gly Asp Ile His Ala Lys Gln Ile Leu Asp Tyr Glu Asn Gly Asn Lys
 420                 425                 430                 435

 tac tgc ctc aca gtc caa gcc aaa gac aaa ggt gat gca act gcc tcc     1521
 Tyr Cys Leu Thr Val Gln Ala Lys Asp Lys Gly Asp Ala Thr Ala Ser
                 440                 445                 450

 tta gtg gtc tgg gtg gat att gaa ggg ata gat gaa ttt gag ccc att     1569
 Leu Val Val Trp Val Asp Ile Glu Gly Ile Asp Glu Phe Glu Pro Ile
             455                 460                 465

 ttc act caa gat cag tat ttt ttc acc ctc cca gaa aag aat aaa gac     1617
 Phe Thr Gln Asp Gln Tyr Phe Phe Thr Leu Pro Glu Lys Asn Lys Asp
         470                 475                 480

 aga cag ttg att ggc aga gtg gaa gcc tca gat gca gat gct ggt att     1665
 Arg Gln Leu Ile Gly Arg Val Glu Ala Ser Asp Ala Asp Ala Gly Ile
     485                 490                 495

 gat gga gtc att ctt tac tcc ctt gga acc tca tct cct ttc ttt tca     1713
 Asp Gly Val Ile Leu Tyr Ser Leu Gly Thr Ser Ser Pro Phe Phe Ser
 500                 505                 510                 515

 gta aat aga acc aat gga aat att tat ttg att aga gcc ctt ccc cta     1761
 Val Asn Arg Thr Asn Gly Asn Ile Tyr Leu Ile Arg Ala Leu Pro Leu
                 520                 525                 530

 ata aaa agt caa ctc aac aaa gaa gac acc ttg gaa atg aaa ata atc     1809
 Ile Lys Ser Gln Leu Asn Lys Glu Asp Thr Leu Glu Met Lys Ile Ile
             535                 540                 545

 gct cat agt ccc aaa tca gat tcc aag ttt gca tct tgc act gtt ttt     1857
 Ala His Ser Pro Lys Ser Asp Ser Lys Phe Ala Ser Cys Thr Val Phe
         550                 555                 560

 gtg aat gtg tct ttc tcc tct gaa gga aca ccc ttg gca gtg ttc gcc     1905
 Val Asn Val Ser Phe Ser Ser Glu Gly Thr Pro Leu Ala Val Phe Ala
     565                 570                 575

 agc agc ttt tca atc agc ctg gtg gtc tcc ttt tta gtg ttt ctg ata     1953
 Ser Ser Phe Ser Ile Ser Leu Val Val Ser Phe Leu Val Phe Leu Ile
 580                 585                 590                 595

 ctc atc tgc att cta att gta atg att tta aga cat aaa caa aaa gac     2001
 Leu Ile Cys Ile Leu Ile Val Met Ile Leu Arg His Lys Gln Lys Asp
                 600                 605                 610

 aca ata aac aat tat gag gag aag aaa acc tca tct tta gat gcg gac     2049
 Thr Ile Asn Asn Tyr Glu Glu Lys Lys Thr Ser Ser Leu Asp Ala Asp
             615                 620                 625

 ttg aga gtg acc cgg gat gcc agt gtg ctc aaa gcc ttc cag aaa act     2097
 Leu Arg Val Thr Arg Asp Ala Ser Val Leu Lys Ala Phe Gln Lys Thr
         630                 635                 640

 gac gac tgc agt aac gag gtg gtc cct gtg gat gcc act ccg gaa tgg     2145
 Asp Asp Cys Ser Asn Glu Val Val Pro Val Asp Ala Thr Pro Glu Trp
     645                 650                 655

 ttg agt tta ata agt atc atg gag aag gat att gtc aat ctg tac aga     2193
 Leu Ser Leu Ile Ser Ile Met Glu Lys Asp Ile Val Asn Leu Tyr Arg
 660                 665                 670                 675

 tac tca aac tcc agt ggc cac tgt tct gtg gaa gga gaa act gca gaa     2241
 Tyr Ser Asn Ser Ser Gly His Cys Ser Val Glu Gly Glu Thr Ala Glu
                 680                 685                 690

 gat aag gaa atc cag agg ata aat gag cat ccc tac aga aag tgc tca     2289
 Asp Lys Glu Ile Gln Arg Ile Asn Glu His Pro Tyr Arg Lys Cys Ser
             695                 700                 705

 gac tca gct ctg agt gac cac gag tcc agg gtg cca gac tcg ggt atc     2337
 Asp Ser Ala Leu Ser Asp His Glu Ser Arg Val Pro Asp Ser Gly Ile
         710                 715                 720

 ccg agg gac tca gac cag ctc tcc tgc cta tct ggg gaa act gat gtg     2385
 Pro Arg Asp Ser Asp Gln Leu Ser Cys Leu Ser Gly Glu Thr Asp Val
     725                 730                 735

 atg gtg act gcc gaa aca gca gaa gcc agc caa aca ttt ggg gaa gga     2433
 Met Val Thr Ala Glu Thr Ala Glu Ala Ser Gln Thr Phe Gly Glu Gly
 740                 745                 750                 755

 gat caa ggg gaa ggc tgc agc acc acc tgt gct caa aat aat gtg tta     2481
 Asp Gln Gly Glu Gly Cys Ser Thr Thr Cys Ala Gln Asn Asn Val Leu
                 760                 765                 770

 ccc cag aca gtt cag aag aga gag gca aaa gag agc atc ctg gct gat     2529
 Pro Gln Thr Val Gln Lys Arg Glu Ala Lys Glu Ser Ile Leu Ala Asp
             775                 780                 785

 gtt aga aaa gag tct gtc ttt att tca ggt gat cag gaa gta agg tgt     2577
 Val Arg Lys Glu Ser Val Phe Ile Ser Gly Asp Gln Glu Val Arg Cys
         790                 795                 800

 gca gct ctt tca act cag acg acc tct gat cat gat gga aaa gac aac     2625
 Ala Ala Leu Ser Thr Gln Thr Thr Ser Asp His Asp Gly Lys Asp Asn
     805                 810                 815

 tat cac tgg aat tat ctt ctt agt tgg gag ccc aaa ttc caa cct ctt     2673
 Tyr His Trp Asn Tyr Leu Leu Ser Trp Glu Pro Lys Phe Gln Pro Leu
 820                 825                 830                 835

 gcc tca gta ttt aat gat att gca aaa cta aag gat gaa cat ttg cat     2721
 Ala Ser Val Phe Asn Asp Ile Ala Lys Leu Lys Asp Glu His Leu His
                 840                 845                 850

 atg cct ggc att cca aaa gag aag aaa tct ttt gtt ttt cca ccc cct     2769
 Met Pro Gly Ile Pro Lys Glu Lys Lys Ser Phe Val Phe Pro Pro Pro
             855                 860                 865

 ttg ata aca gca gta gcc cag cct ggg att aaa gca gtc cca cca aga     2817
 Leu Ile Thr Ala Val Ala Gln Pro Gly Ile Lys Ala Val Pro Pro Arg
         870                 875                 880

 atg ccg gca gta aac ctg ggg cag gtg cct ccg aaa cac cca cgc tct     2865
 Met Pro Ala Val Asn Leu Gly Gln Val Pro Pro Lys His Pro Arg Ser
     885                 890                 895

 ccc atc ccc tac cat ctt ggt tct ctg cca gaa ggc atg act ccc aat     2913
 Pro Ile Pro Tyr His Leu Gly Ser Leu Pro Glu Gly Met Thr Pro Asn
 900                 905                 910                 915

 ttt tct cca tct ctt tcc cta ttg acg atg cag cct cct gcc ttg tct     2961
 Phe Ser Pro Ser Leu Ser Leu Leu Thr Met Gln Pro Pro Ala Leu Ser
                 920                 925                 930

 cca ctg ttg aga gaa gga gaa tta tta gga aca cac atc agt ggt aca     3009
 Pro Leu Leu Arg Glu Gly Glu Leu Leu Gly Thr His Ile Ser Gly Thr
             935                 940                 945

 tgc cat gaa ctt aaa gca gaa gat gaa gtt caa ata tga aaccactggg      3058
 Cys His Glu Leu Lys Ala Glu Asp Glu Val Gln Ile 
         950                 955

 atgccaagta cctgctcacc attggtcatg aatgaatgaa caaaatgttt tcaagccagc   3118

 aactcgagat tgggctcatt tttatctaaa agcaagtgat gtaatttagt tagagttttt   3178

 aaaacttccc cattaaagtt tctccaattt cttccagcct taatgaaaag ttatttcctc   3238

 ttttaatcct tatgtgttgc tctcaggact cacatttgta tatattaagt agtgtatatt   3298

 ctgtcagacc tgttgtctgt atgattagac ttccaaagga cacagtgaac ttaactgact   3358

 gccagaatgt ttatatggaa acaaaatata gtgtactctg gtcacattgc tgctgatcac   3418

 actgctatat caaaaacaaa ctagtaaagg ctaaatggag aatgagttta ggtcagaaca   3478

 tatagcagag aggggaagtc tagaggaata aactttcatt ttaagatg                3526




      <210> 396
      <211> 527
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (31)..(381)

      <400> 396
 tgaagatcag gctctgcaaa tcaccctagg     atg tcc ttc agt gag cag cag      51
                                      Met Ser Phe Ser Glu Gln Gln
                                        1               5

 tgc aag cag cca tgt gtg ccc cct cca tgc ctc cca aag acc cag gag       99
 Cys Lys Gln Pro Cys Val Pro Pro Pro Cys Leu Pro Lys Thr Gln Glu
          10                  15                  20

 cag tgc caa gca aag gct gag gag gtg tgc ctc ccc aca tgc cag cac      147
 Gln Cys Gln Ala Lys Ala Glu Glu Val Cys Leu Pro Thr Cys Gln His
      25                  30                  35

 ccc tgc caa gat aag tgt cta gtg cag gcc cag gag gta tgt ctt tct      195
 Pro Cys Gln Asp Lys Cys Leu Val Gln Ala Gln Glu Val Cys Leu Ser
  40                  45                  50                  55

 cag tgc cag gaa tca agt caa gaa aaa tgc cca cag caa ggc caa gag      243
 Gln Cys Gln Glu Ser Ser Gln Glu Lys Cys Pro Gln Gln Gly Gln Glu
                  60                  65                  70

 cca tac cta cct cca tgc caa gac cag tgt cca cct cag tgt gca gag      291
 Pro Tyr Leu Pro Pro Cys Gln Asp Gln Cys Pro Pro Gln Cys Ala Glu
              75                  80                  85

 cca tgc cag gag cta ttc cag aca aaa tgt gtg gag gtt tgc cca cag      339
 Pro Cys Gln Glu Leu Phe Gln Thr Lys Cys Val Glu Val Cys Pro Gln
          90                  95                 100

 aaa gtc cag gag aag tgc tca tcc cct ggc aag gga aag tag ctgctca      388
 Lys Val Gln Glu Lys Cys Ser Ser Pro Gly Lys Gly Lys 
     105                 110                 115

 tatgtcatct gggttcaaga agatggccag cagatgaaac cctgacccca gcccacgctc    448

 tggtgacctt cttctgtggg tacctctgtg tgcaatgtac cttcttgact cctggcttcc    508

 ttagcattcc aggacttgg                                                 527




      <210> 397
      <211> 1190
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(615)

      <400> 397
 gagtcgaccc acgcgtccgc ggacgcgtgg gcggacgcgt ggctgggttt tgcatccaga     60

 ctgagtttcc ttccctcacc cacatgaagt gtctaccttc tgcagactcc a atg gct     117
                                                          Met Ala
                                                            1

 cag gaa ctg gga atg cag tgc cag gct cgt ggt atc ctg cag cag atg      165
 Gln Glu Leu Gly Met Gln Cys Gln Ala Arg Gly Ile Leu Gln Gln Met
           5                  10                  15

 tgg gga gtt ttc ctt ctt tat gtt tcc atg aag atg gga ggc act aca      213
 Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr Thr
      20                  25                  30

 gga caa aac att gac cag ccc act gag atg aca gct acg gaa ggt gcc      261
 Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly Ala
  35                  40                  45                  50

 att gtc cag atc aac tgc acg tac cag aca tct ggg ttc aac ggg ctg      309
 Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly Leu
                  55                  60                  65

 ttc tgg tac cag caa cat gct ggc gaa gca ccc aca ttt ctg tct tac      357
 Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser Tyr
              70                  75                  80

 aat gtt ctg gat ggt ttg gag gag aaa ggt cgt ttt tct tca ttc ctt      405
 Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe Leu
          85                  90                  95

 agt cgg tct aaa ggg tac agt tac ctc ctt ttg aag gag ctc cag atg      453
 Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln Met
     100                 105                 110

 aaa gac tct gcc tct tac ctc tgt gct gtt tcg tca gga acc tac aaa      501
 Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Ser Ser Gly Thr Tyr Lys
 115                 120                 125                 130

 tac atc ttt gga aca ggc acc agg ctg aag gtt tta gca agt gag tat      549
 Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val Leu Ala Ser Glu Tyr
                 135                 140                 145

 tac aga caa gac agg ctg tat ttt aaa ggt tgt tgg tgt tca tgt ttg      597
 Tyr Arg Gln Asp Arg Leu Tyr Phe Lys Gly Cys Trp Cys Ser Cys Leu
             150                 155                 160

 agg gac aag gga agg tag gacaag ggaaataccc atgtacactg tgcaagctaa      651
 Arg Asp Lys Gly Arg 
         165

 aatccctgct atctgaagcg gcaattctgg gtccctctac tctggacagg aggggcgaag    711

 gagagctctg aggcttacca tgatggactt actgccgatt tcataagaat tgtatccatc    771

 attagcaaaa tgtttatgac ttgaaggcct caagaaactc ctgttaacac aacaggagtt    831

 ctgtgttctt tattctttta aaactatatt ctcactttac atttttcact catttttctg    891

 ccttttttat gcgtctctcc tctgtgcaac tcaatgcttc atctgggcat tcatattttg    951

 agaaatcatc tcaagaggaa atcatgtcca gatcctagca tgtcactcaa agctctctga   1011

 aatctgggcc ctttctattc tccaaattta ttcccactga ttccctttca tgaatgctct   1071

 gctccaggaa aactaggtat cctcagaaca acgacagcct agagcggccg caatacagtg   1131

 ctgggattac aggcgtgagc caccacacga aatcgtcgac agcgaagtcg acccgggaa    1190




      <210> 398
      <211> 2390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(1914)

      <400> 398
 gtccggaatt cccgggtcga cgatttcgtc gttgagttgc acagcggtat tctcaccagg     60

 ccctgcaatc ggtgggccac agtgccggcc acagag  atg gtg gaa gga cca ggc     114
                                          Met Val Glu Gly Pro Gly
                                            1               5

 tgt act ctg aat gga gag aag att cgc gcg cgg gtg ctc ccg ggc cag      162
 Cys Thr Leu Asn Gly Glu Lys Ile Arg Ala Arg Val Leu Pro Gly Gln
              10                  15                  20

 gcg gtg acc ggc gtg cgg gga agc gct ctg cgg agt ctg cag ggc cgc      210
 Ala Val Thr Gly Val Arg Gly Ser Ala Leu Arg Ser Leu Gln Gly Arg
          25                  30                  35

 gcc ttg cgg ctc gca gcc tcc acg gtt gtg gtc tcc ccg cag gct gct      258
 Ala Leu Arg Leu Ala Ala Ser Thr Val Val Val Ser Pro Gln Ala Ala
      40                  45                  50

 gca ctg aat aat gat tcc agc cag aat gtc ttg agc ctg ttt aat gga      306
 Ala Leu Asn Asn Asp Ser Ser Gln Asn Val Leu Ser Leu Phe Asn Gly
  55                  60                  65                  70

 tat gtt tac agt ggc gtg gaa act ttg ggg aag gag ctc ttt atg tac      354
 Tyr Val Tyr Ser Gly Val Glu Thr Leu Gly Lys Glu Leu Phe Met Tyr
                  75                  80                  85

 ttt gga cca aaa gct tta cgg att cat ttc gga atg aaa ggc ttc atc      402
 Phe Gly Pro Lys Ala Leu Arg Ile His Phe Gly Met Lys Gly Phe Ile
              90                  95                 100

 atg att aat cca ctt gag tat aaa tat aaa aat gga gct tct cct gtt      450
 Met Ile Asn Pro Leu Glu Tyr Lys Tyr Lys Asn Gly Ala Ser Pro Val
         105                 110                 115

 ttg gaa gtg cag ctc acc aaa gat ttg att tgt ttc ttt gac tca tca      498
 Leu Glu Val Gln Leu Thr Lys Asp Leu Ile Cys Phe Phe Asp Ser Ser
     120                 125                 130

 gta gaa ctc aga aac tca atg gaa agc caa cag aga ata aga atg atg      546
 Val Glu Leu Arg Asn Ser Met Glu Ser Gln Gln Arg Ile Arg Met Met
 135                 140                 145                 150

 aaa gaa tta gat gta tgt tca cct gaa ttt agt ttc ttg aga gca gaa      594
 Lys Glu Leu Asp Val Cys Ser Pro Glu Phe Ser Phe Leu Arg Ala Glu
                 155                 160                 165

 agt gaa gtt aaa aaa cag aaa ggc cgg atg cta ggt gat gtg cta atg      642
 Ser Glu Val Lys Lys Gln Lys Gly Arg Met Leu Gly Asp Val Leu Met
             170                 175                 180

 gat cag aac gta ttg cct gga gta ggg aac atc atc aaa aat gaa gct      690
 Asp Gln Asn Val Leu Pro Gly Val Gly Asn Ile Ile Lys Asn Glu Ala
         185                 190                 195

 ctc ttt gac agt ggt ctc cac cca gct gtt aaa gtt tgt caa tta aca      738
 Leu Phe Asp Ser Gly Leu His Pro Ala Val Lys Val Cys Gln Leu Thr
     200                 205                 210

 gat gaa cag atc cat cac ctc atg aaa atg ata cgt gat ttc agc att      786
 Asp Glu Gln Ile His His Leu Met Lys Met Ile Arg Asp Phe Ser Ile
 215                 220                 225                 230

 ctc ttt tac agg tgc cgt aaa gca gga ctt gct ctc tct aaa cac tat      834
 Leu Phe Tyr Arg Cys Arg Lys Ala Gly Leu Ala Leu Ser Lys His Tyr
                 235                 240                 245

 aag gtt tac aag cgt cct aat tgt ggt cag tgc cac tgc aga ata act      882
 Lys Val Tyr Lys Arg Pro Asn Cys Gly Gln Cys His Cys Arg Ile Thr
             250                 255                 260

 gtg tgc cgc ttt ggg gac aat aac aga atg aca tat ttc tgt cct cac      930
 Val Cys Arg Phe Gly Asp Asn Asn Arg Met Thr Tyr Phe Cys Pro His
         265                 270                 275

 tgt caa aaa gaa aat cct caa cat gtt gac ata tgc aag cta ccg act      978
 Cys Gln Lys Glu Asn Pro Gln His Val Asp Ile Cys Lys Leu Pro Thr
     280                 285                 290

 aga aat act ata atc agt tgg aca tct agc agg gtg gat cat gtt atg     1026
 Arg Asn Thr Ile Ile Ser Trp Thr Ser Ser Arg Val Asp His Val Met
 295                 300                 305                 310

 gac tcc gtg gct cgg aag tcg gaa gag cac tgg acc tgt gtg gtg tgt     1074
 Asp Ser Val Ala Arg Lys Ser Glu Glu His Trp Thr Cys Val Val Cys
                 315                 320                 325

 act tta atc aat aag ccc tct tct aag gca tgt gat gct tgc ttg acc     1122
 Thr Leu Ile Asn Lys Pro Ser Ser Lys Ala Cys Asp Ala Cys Leu Thr
             330                 335                 340

 tca agg cct att gat tca gtg ctc aag agt gaa gaa aat tct act gtc     1170
 Ser Arg Pro Ile Asp Ser Val Leu Lys Ser Glu Glu Asn Ser Thr Val
         345                 350                 355

 ttt agc cac tta atg aag tac ccg tgt aat act ttt gga aaa cct cat     1218
 Phe Ser His Leu Met Lys Tyr Pro Cys Asn Thr Phe Gly Lys Pro His
     360                 365                 370

 aca gaa gtc aag atc aac agg aaa act gca ttt gga act aca act ctt     1266
 Thr Glu Val Lys Ile Asn Arg Lys Thr Ala Phe Gly Thr Thr Thr Leu
 375                 380                 385                 390

 gtc ttg act gat ttt agc aat aaa tcc agt act ttg gaa aga aaa aca     1314
 Val Leu Thr Asp Phe Ser Asn Lys Ser Ser Thr Leu Glu Arg Lys Thr
                 395                 400                 405

 aag caa aac cag ata cta gat gag gag ttt caa aac tct cct cct gct     1362
 Lys Gln Asn Gln Ile Leu Asp Glu Glu Phe Gln Asn Ser Pro Pro Ala
             410                 415                 420

 agt gtg tgt ttg aat gat ata cag cac ccc tcc aag aag aca aca aac     1410
 Ser Val Cys Leu Asn Asp Ile Gln His Pro Ser Lys Lys Thr Thr Asn
         425                 430                 435

 gat ata act caa cta tcc agc aaa gta aac ata tca cct aca atc agt     1458
 Asp Ile Thr Gln Leu Ser Ser Lys Val Asn Ile Ser Pro Thr Ile Ser
     440                 445                 450

 tca gaa tct aaa tta ttt agt cca gca cat aaa aaa ccg aaa aca gcc     1506
 Ser Glu Ser Lys Leu Phe Ser Pro Ala His Lys Lys Pro Lys Thr Ala
 455                 460                 465                 470

 cac tac tca tca cca gag ctt aaa agc tgc aac cct gga tat tct aac     1554
 His Tyr Ser Ser Pro Glu Leu Lys Ser Cys Asn Pro Gly Tyr Ser Asn
                 475                 480                 485

 agt gaa ctt caa att aat atg aca gat ggc cct cgt acc tta aat cct     1602
 Ser Glu Leu Gln Ile Asn Met Thr Asp Gly Pro Arg Thr Leu Asn Pro
             490                 495                 500

 gac agc cct cgc tgc agt aaa cac aac cgc ctc tgc att ctc cga gtt     1650
 Asp Ser Pro Arg Cys Ser Lys His Asn Arg Leu Cys Ile Leu Arg Val
         505                 510                 515

 gtg agg aag gat ggg gaa aac aag ggc agg cag ttt tat gcc tgt cct     1698
 Val Arg Lys Asp Gly Glu Asn Lys Gly Arg Gln Phe Tyr Ala Cys Pro
     520                 525                 530

 cta cct aga gaa gca caa tgt gga ttt ttt gaa tgg gca gat ttg tcc     1746
 Leu Pro Arg Glu Ala Gln Cys Gly Phe Phe Glu Trp Ala Asp Leu Ser
 535                 540                 545                 550

 ttc cca ttc tgc aac cat ggc aag cgt tcc acc atg aaa aca gta ttg     1794
 Phe Pro Phe Cys Asn His Gly Lys Arg Ser Thr Met Lys Thr Val Leu
                 555                 560                 565

 aag att gga cct aac aat gga aag aat ttt ttt gtg tgt cct ctt ggg     1842
 Lys Ile Gly Pro Asn Asn Gly Lys Asn Phe Phe Val Cys Pro Leu Gly
             570                 575                 580

 aag gaa aaa caa tgc aat ttt ttc cag tgg gca gaa aat ggg cca gga     1890
 Lys Glu Lys Gln Cys Asn Phe Phe Gln Trp Ala Glu Asn Gly Pro Gly
         585                 590                 595

 ata aaa att att cct gga tgc taa tatctgtaga ttctctggca tttagtctct    1944
 Ile Lys Ile Ile Pro Gly Cys 
     600                 605

 tcaaactgtg tataatgttt ggtcctcctc tgtttcatag aaaagtcata gaatatctat   2004

 gatacattga aaagttactg caatatttga gaactgttct ttttttttct tgtgtgtgcc   2064

 atctttccat tgttggctac gtcttttctt ttgccttgat gaacgttcta tgtatttcat   2124

 cggatataca gcatattcca tttaggatgt gtatttaatg catttagtaa tgacgataaa   2184

 gtgtttttag tatgctttta gtctcttgta actggggaga agcagtgttt tttttttagg   2244

 aaaggattat gcgacacaat aaaataagat attctgtctg tagtgaatac atttctcatg   2304

 tactaacact atttataata tatgattaaa gatatttctt gttttattaa ataataagaa   2364

 ataagatctc ctttaaaaaa aaaaaa                                        2390




      <210> 399
      <211> 790
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(440)

      <400> 399
 ggaattcccg ggtcgacgat ttcgtggaaa ttctttaaac ctagaatcag acacaaaaac     60

 tgaactctgg gtccacaatc ctcatttgtc cttgaagt    atg agg ctg gtg gca     113
                                              Met Arg Leu Val Ala
                                                1               5

 aga gta act gtg ttt ctg acc ttt gga act ata att gat gct aag acc      161
 Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr
                  10                  15                  20

 acc cag ccc ccc tcc atg gat tgc gct gaa gga aga gct gca aac ctg      209
 Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu
              25                  30                  35

 cct tgt aat cac tct acc atc agt gga aat gag tat gtg tat tgg tat      257
 Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr
          40                  45                  50

 cga cag att cac tcc cag ggg cca cag tat atc att cat ggt cta aaa      305
 Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys
      55                  60                  65

 aac aat gaa acc aat gaa ata gcc tct ctg atc atc aca gaa gac aga      353
 Asn Asn Glu Thr Asn Glu Ile Ala Ser Leu Ile Ile Thr Glu Asp Arg
  70                  75                  80                  85

 aag tcc agc acc ttg atc ctg ccc cac gct acg ctg aga gac act gct      401
 Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala
                  90                  95                 100

 gtg tac tat tgc atc gtc gca ttc agg agg agg tgc tga cggactcacc       450
 Val Tyr Tyr Cys Ile Val Ala Phe Arg Arg Arg Cys 
             105                 110

 tttggcaaag ggactcatct aatcatccag ccctgtaagt gcttttgcct gggaggtggg    510

 gttcaaaatg cagtcctcat ggggacattt ctaaaccttg gctcatgtgc ttctggtgcc    570

 actaccattt ttggcactat cctacttaca tgggagggtt tgagccatgt agacaaggga    630

 ggggaggcag ttgggctttt ggagaatttt gagatggggg ttttgggaaa tggggttgaa    690

 taagagggcc ctcttggaac aaccggggtg ccggcaaaaa aacagaattg ggcttgggga    750

 ggggtaaaaa aaatggggag gacttttgcc cgcaaccttt                          790




      <210> 400
      <211> 1638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(1304)

      <400> 400
 atatttccgg gcgacgattt cgggggcctg attacaaggc cctggaggta ctttaaagag     60

 ggctgctcaa ctgcaaggac gctgtaagca ggaagagaag ccacagcgct tcagaaaaga    120

 gtgggacagg gacaagcata tctaagaggc tgaac   atg aat cca cag atc aga     173
                                          Met Asn Pro Gln Ile Arg
                                            1               5

 aac ccg atg aag gca atg tat cca ggc aca ttc tac ttc caa ttt aaa      221
 Asn Pro Met Lys Ala Met Tyr Pro Gly Thr Phe Tyr Phe Gln Phe Lys
              10                  15                  20

 aac cta tgg gaa gcc aac gat cgg aac gaa act tgg ctg tgc ttc acc      269
 Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu Thr Trp Leu Cys Phe Thr
          25                  30                  35

 gtg gaa ggt ata aag cgc cgc tca gtt gtc tcc tgg aag acg ggc gtc      317
 Val Glu Gly Ile Lys Arg Arg Ser Val Val Ser Trp Lys Thr Gly Val
      40                  45                  50

 ttc cga aac cag gtg gat tct gag acc cat tgt cat gca gaa agg tgc      365
 Phe Arg Asn Gln Val Asp Ser Glu Thr His Cys His Ala Glu Arg Cys
  55                  60                  65                  70

 ttc ctc tct tgg ttc tgc gac gac ata ctg tct cct aac aca aag tac      413
 Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Lys Tyr
                  75                  80                  85

 cag gtc acc tgg tac aca tct tgg agc cct tgc cca gac tgt gca ggg      461
 Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro Cys Pro Asp Cys Ala Gly
              90                  95                 100

 gag gtg gcc gag ttc ctg gcc agg cac agc aac gtg aat ctc acc atc      509
 Glu Val Ala Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile
         105                 110                 115

 ttc acc gcc cgc ctc tac tac ttc cag tat cca tgt tac cag gag ggg      557
 Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr Pro Cys Tyr Gln Glu Gly
     120                 125                 130

 ctc cgc agc ctg agt cag gaa ggg gtc gct gtg gag atc atg gac tat      605
 Leu Arg Ser Leu Ser Gln Glu Gly Val Ala Val Glu Ile Met Asp Tyr
 135                 140                 145                 150

 gaa gat ttt aaa tat tgt tgg gaa aac ttt gtg tac aat gat aat gag      653
 Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asn Glu
                 155                 160                 165

 cca ttc aag cct tgg tac aaa ttc gat gaa aat tat gca ttc ctg cac      701
 Pro Phe Lys Pro Trp Tyr Lys Phe Asp Glu Asn Tyr Ala Phe Leu His
             170                 175                 180

 cgc acg cta aag gag att ctc aga tac ctg atg gat cca gac aca ttc      749
 Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu Met Asp Pro Asp Thr Phe
         185                 190                 195

 act ttc aac ttt aat aat gac cct ttg gtc ctt cga cgg cgc cag acc      797
 Thr Phe Asn Phe Asn Asn Asp Pro Leu Val Leu Arg Arg Arg Gln Thr
     200                 205                 210

 tac ttg tgc tat gag gtg gag cgc ctg gac aat ggc acc tgg gtc ctg      845
 Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Trp Val Leu
 215                 220                 225                 230

 atg gac cag cac atg ggc ttt cta tgc aac gag gct aag aat ctt ctc      893
 Met Asp Gln His Met Gly Phe Leu Cys Asn Glu Ala Lys Asn Leu Leu
                 235                 240                 245

 tgt ggc ttt tac ggc cgc cat gcg gag ctg cgc ttc ttg gac ctg gtt      941
 Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val
             250                 255                 260

 cct tct ttg cag ttg gac ccg gcc cag atc tac agg gtc act tgg ttc      989
 Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe
         265                 270                 275

 atc tcc tgg agc ccc tgc ttc tcc tgg ggc tgt gcc ggg gaa gtg cgt     1037
 Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg
     280                 285                 290

 gcg ttc ctt cag gag aac aca cac gtg aga ctg cgc atc ttc gct gcc     1085
 Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala
 295                 300                 305                 310

 cgc atc tat gat tac gac ccc cta tat aag gag gcg ctg caa atg ctg     1133
 Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu
                 315                 320                 325

 cgg gat gct ggg gcc caa gtc tcc atc atg acc tac gat gag ttt gag     1181
 Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Glu
             330                 335                 340

 tac tgc tgg gac acc ttt gtg tac cgc cag gga tgt ccc ttc cag ccc     1229
 Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln Gly Cys Pro Phe Gln Pro
         345                 350                 355

 tgg gat gga cta gag gag cac agc caa gcc ctg agt ggg agg ctg cgg     1277
 Trp Asp Gly Leu Glu Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg
     360                 365                 370

 gcc att ctc cag aat cag gga aac tga aggat gggcctcagt ctctaaggaa     1329
 Ala Ile Leu Gln Asn Gln Gly Asn 
 375                 380

 ggcagagacc tgggttgagc agcagaataa aagatcttct tccaagaaat gcaaacagac   1389

 cgttcaccac catctccagc tgctcacaga caccagcaaa gcaatgtgct cctgatcaag   1449

 tagatttttt aaaaatcaga gtcaattaat tttaattgaa aatttctctt atgttccaag   1509

 tgtacaagag taagattatg ctcaatattc ccagaatagt tttcaatgta ttaatgaagt   1569

 gattaattgg ctccatattt agactaataa aacattaaga atcttccata attgtttcca   1629

 caaacacta                                                           1638




      <210> 401
      <211> 935
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(653)

      <400> 401
 ggaattcccg ggtcgacgtt ttcgtcggca cccggagctc ctgggcacac ggcattggca     60

 ggggccgctt cggcagagtg    atg act gat gat gag tcc gag agc gtc ctc     110
                          Met Thr Asp Asp Glu Ser Glu Ser Val Leu
                            1               5                  10

 tcc gac tcc cat gaa ggg tcg gag ctg gag ctg cct gtt atc cag ctg      158
 Ser Asp Ser His Glu Gly Ser Glu Leu Glu Leu Pro Val Ile Gln Leu
                  15                  20                  25

 tgc ggg ctg gtg gag gag ctc agc tat gta aac tct gct ctc aaa act      206
 Cys Gly Leu Val Glu Glu Leu Ser Tyr Val Asn Ser Ala Leu Lys Thr
              30                  35                  40

 gag act gag atg ttt gag aaa tat tac gct aaa ctg gag ccc agg gat      254
 Glu Thr Glu Met Phe Glu Lys Tyr Tyr Ala Lys Leu Glu Pro Arg Asp
          45                  50                  55

 cag cga cct cca cga tta tca gaa att aaa ata tca gca gca gat tat      302
 Gln Arg Pro Pro Arg Leu Ser Glu Ile Lys Ile Ser Ala Ala Asp Tyr
      60                  65                  70

 gca cag ttt cga ggc agg cgt aga tcc aaa tcc cgg aca ggt atg gac      350
 Ala Gln Phe Arg Gly Arg Arg Arg Ser Lys Ser Arg Thr Gly Met Asp
  75                  80                  85                  90

 cgt ggg gta ggc ctg act gcc gac caa aaa ctt gag ctg gta caa aaa      398
 Arg Gly Val Gly Leu Thr Ala Asp Gln Lys Leu Glu Leu Val Gln Lys
                  95                 100                 105

 gag gtt gcg gac atg aag gat gac tta cga cac aca agg gca aat gcg      446
 Glu Val Ala Asp Met Lys Asp Asp Leu Arg His Thr Arg Ala Asn Ala
             110                 115                 120

 gaa cgc gac ctg cag cat cac gag gcg atc att gag gag gct gaa att      494
 Glu Arg Asp Leu Gln His His Glu Ala Ile Ile Glu Glu Ala Glu Ile
         125                 130                 135

 cga tgg agt gaa gtt tcg aga gaa gtg cat gag ttt gaa aaa gat att      542
 Arg Trp Ser Glu Val Ser Arg Glu Val His Glu Phe Glu Lys Asp Ile
     140                 145                 150

 cta aaa gcc ata tcc aag aag aaa ggg agt att ttg gcc act cag aaa      590
 Leu Lys Ala Ile Ser Lys Lys Lys Gly Ser Ile Leu Ala Thr Gln Lys
 155                 160                 165                 170

 gtg atg aaa tac att gag gac atg aac cgc cgg agg gat aat atg aag      638
 Val Met Lys Tyr Ile Glu Asp Met Asn Arg Arg Arg Asp Asn Met Lys
                 175                 180                 185

 gag aat tac gtt tga aaaatgtttc tctcaaagtt cagaggaaaa aaatgctttt      693
 Glu Asn Tyr Val 
             190

 acaattgagg cagaaggaag aggtgagtga ggcccttcac gatgttgatt ttcagcagtt    753

 gaagatagag aacgctcaat ttcttgagac aattgacgca aggaatcaag aattgaccca    813

 gctaaagctg tcatctggaa acactctgca ggttctcaat gcctacaaaa gcaagcttca    873

 caaggcaatg gaaatatacc tcaatctgga caaggagatc ttgctgagaa aagagctact    933

 gt                                                                   935




      <210> 402
      <211> 1648
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(593)

      <400> 402
 gagtactctg caggtaccgc gtccggattc ccgggtcgac ccacgcgtcc gagcggcggt     60

 agctgcagct ggcgaagttg ggcgactggc gg  atg cag gcc ttg cgg cac gtc     113
                                      Met Gln Ala Leu Arg His Val
                                        1               5

 gtg tgc gcc ctg tcc ggc ggc gtg gac agc gcc gtg gcc gcg ctg ctg      161
 Val Cys Ala Leu Ser Gly Gly Val Asp Ser Ala Val Ala Ala Leu Leu
          10                  15                  20

 ctg agg cgg aga ggt tac cag gtg aca ggg gtg ttt atg aag aac tgg      209
 Leu Arg Arg Arg Gly Tyr Gln Val Thr Gly Val Phe Met Lys Asn Trp
      25                  30                  35

 gac tca ctg gat gaa cat ggg gtc tgt act gcc gac aaa gac tgt gaa      257
 Asp Ser Leu Asp Glu His Gly Val Cys Thr Ala Asp Lys Asp Cys Glu
  40                  45                  50                  55

 gat gct tac aga gtt tgc cag atc tta gac atc cct ttc cat caa gtg      305
 Asp Ala Tyr Arg Val Cys Gln Ile Leu Asp Ile Pro Phe His Gln Val
                  60                  65                  70

 tcc tac gta aag gag tat tgg aat gat gtg ttc agt gac ttt ttg aat      353
 Ser Tyr Val Lys Glu Tyr Trp Asn Asp Val Phe Ser Asp Phe Leu Asn
              75                  80                  85

 gag tat gaa aaa gga agg act ccc aat cct gac ata gtt tgc aac aag      401
 Glu Tyr Glu Lys Gly Arg Thr Pro Asn Pro Asp Ile Val Cys Asn Lys
          90                  95                 100

 cac atc aaa ttt agt tgc ttt ttt cat tat gct gtg gat aat ctt ggg      449
 His Ile Lys Phe Ser Cys Phe Phe His Tyr Ala Val Asp Asn Leu Gly
     105                 110                 115

 gca gat gcc att gcc aca ggt cac tat gca aga act tcc ctg gaa gat      497
 Ala Asp Ala Ile Ala Thr Gly His Tyr Ala Arg Thr Ser Leu Glu Asp
 120                 125                 130                 135

 gaa gaa gtc ttt gag cag aag cac gtt aag aag ccc gaa ggg ctt ttc      545
 Glu Glu Val Phe Glu Gln Lys His Val Lys Lys Pro Glu Gly Leu Phe
                 140                 145                 150

 aga aat cgg ttt gaa gtt aga aat gcc agg ttt ccc agg atg ccc tga      593
 Arg Asn Arg Phe Glu Val Arg Asn Ala Arg Phe Pro Arg Met Pro 
             155                 160                 165

 ggagaaccat cttccctctg gggggattaa cgaaagagtt tgtaaagaaa atcgctgctg    653

 agaatagact tcatcatgtg cttcagaaga aagagagcat gggcatgtgt ttcatcggga    713

 agaggaattt tgaacatttc cttcttcagt atctgcagcc tcgacctggt cactttattt    773

 ccatagaaga caataaggtt ctgggaacac ataaaggttg gttcctgtat accttgggcc    833

 agagagcaaa cataggtggc ctgagagagc cctggtacgt ggtggagaag gacagcgtca    893

 agggtgacgt gtttgtggcc ccccggacag accacccagc cctgtacagg gacctgctga    953

 ggaccagccg cgtgcactgg attgcggagg agcctcccgc agcactggtc cgggacaaga   1013

 tgatggagtg ccacttccga ttccgccacc agatggcact agtgccctgt gtgctgaccc   1073

 tcaatcaaga tggcaccgtg tgggtgacag ctgtgcaggc tgtgcgtgcc cttgccacag   1133

 gacagtttgc tgtgttctac aagggggacg agtgcctggg cagcgggaag atcctgcggc   1193

 tggggccgtc tgcctacacg ctccagaagg gccagcgcag agctgggatg gccactgaga   1253

 gccccagtga cagcccagaa gatggtccag gcctgagtcc cttgctctga cagagatgga   1313

 tctgctagaa ggaacctgga gagcaggacc catggctggg cggctggtga gcagtccagg   1373

 tgcccaaggg ccagcttgct gctgcccaaa gcagaggaag ccgggctggc tgagggtccg   1433

 aaaagcctgc aggggcccgg cgagccccag gaagagcctc agctccaggc tggggctctg   1493

 gctgctggag catctgctgg ctggtggggt ggcccgagtt ccccttcacc gcccccaggg   1553

 agggtttccc acctcagagt acaccgaggg gacctgcaga gggggctgtc gggacagcgt   1613

 ggaataaaca ttatttcaag gacaaaaaaa aaaaa                              1648




      <210> 403
      <211> 1067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(591)

      <400> 403
 aattcccggg tcgacccacg cgtccgctca cctctgaaca gaaacccacc ctccacccct     60

 gacacc   atg acc cac tgt tgc tcc cct tgc tgt cag cct acc tgc tgc     108
          Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys
            1               5                  10

 agg acc acc tgc tgc agg acc acc tgc tgg aag ccc acc act gtg acc      156
 Arg Thr Thr Cys Cys Arg Thr Thr Cys Trp Lys Pro Thr Thr Val Thr
  15                  20                  25                  30

 acc tgc agc agc aca ccc tgc tgc cag ccc tcc tgc tgt gtg tct agc      204
 Thr Cys Ser Ser Thr Pro Cys Cys Gln Pro Ser Cys Cys Val Ser Ser
                  35                  40                  45

 tgc tgc cag cct tgc tgc cgc cca gct tgc tgt caa aac acc tgc tgc      252
 Cys Cys Gln Pro Cys Cys Arg Pro Ala Cys Cys Gln Asn Thr Cys Cys
              50                  55                  60

 agg acc acc tgc tgc cag ccc acc tgt ctg acc agc tgc tgc cag cct      300
 Arg Thr Thr Cys Cys Gln Pro Thr Cys Leu Thr Ser Cys Cys Gln Pro
          65                  70                  75

 tcc tgc tgc agc aca acc tgc tgc cag ccc atc tgc tgt ggg tcc agc      348
 Ser Cys Cys Ser Thr Thr Cys Cys Gln Pro Ile Cys Cys Gly Ser Ser
      80                  85                  90

 tgc tgt ggc caa acc agc tgt ggg tcc agc tgt ggc cag agc agc tcc      396
 Cys Cys Gly Gln Thr Ser Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser
  95                 100                 105                 110

 tgt gca cct gtg tac tgc aga aga acc tgc tac tac ccg acg act gtc      444
 Cys Ala Pro Val Tyr Cys Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val
                 115                 120                 125

 tgc ctg cct ggt tgc ctc aac cag agc tgt gga tcc agc tgc tgc cag      492
 Cys Leu Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Ser Cys Cys Gln
             130                 135                 140

 ccc tgc tgc cgc ccc gcc tgc tgt gag acc acc tgc tgc agg acc act      540
 Pro Cys Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr
         145                 150                 155

 tgc ttc cag ccc acc tgt gtg tcc agc tgc tgc cag cct tct tgc tgc      588
 Cys Phe Gln Pro Thr Cys Val Ser Ser Cys Cys Gln Pro Ser Cys Cys
     160                 165                 170

 tga tcaa gtcccaagag aacaaccatc ttcacacaac aaccttctgc tcaactgact      645
 


 tatcttttgg aggactaatt taccttactg ctgacagcaa ccatgttctc acccaaattt    705

 ttatgaattc tctgcatatt taaaatcttg tgaatcagct tgagggaggg cagaatactt    765

 catcctgatt ctctttttct tataccttgt gaatcatgtg ccagcttcat ctgttctcaa    825

 ttttgagtca tggtctcagc tttgactcaa aagtcaagag cttcattctc ttcacttaag    885

 aaacttaagt tgctgcaaat gattaagaat cttcacaact atgttttctt ttcaatatac    945

 tcatgattct tgtatcctgc ttccttcttt taatgatcac tttgggttat ctccctataa   1005

 ccagggatct tacctatata tttctacgaa atcgtcgaca gcgaagtcga cccgggaatt   1065

 cc                                                                  1067




      <210> 404
      <211> 1189
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (279)..(1136)

      <400> 404
 ccgcccgaat tcccggtcga cttcgctgtc gacgatttcg tggctgtgaa agcatttggg     60

 aaagattttg acagttttta aagcacctta acaatgaaca cgcattggat gaccgaagca    120

 ctgctcagtg tcgagtgcaa atgcaggtgg tgcaacagtt agaaatacag ctttctaaag    180

 aacgcgaacg tcttcaagca atgatgaccc acttgcacat gcgaccctca gagcccaaat    240

 catctcccaa acctctaaat ctggtgtcta gtgtcacc    atg tcg aag aat atg     293
                                              Met Ser Lys Asn Met
                                                1               5

 ttg gag aca tcc cca cag agc tta cct caa acc cct acc aca cca acg      341
 Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr Pro Thr
                  10                  15                  20

 gcc cca gtc acc ccg att acc cag gga ccc tca gta atc acc cca gcc      389
 Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile Thr Pro Ala
              25                  30                  35

 agt gtg ccc aat gtg gga gcc ata cga agg cga cat tca gac aaa tac      437
 Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser Asp Lys Tyr
          40                  45                  50

 aac att ccc atg tca tca gaa att gcc cca aac tat gaa ttt tat aaa      485
 Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe Tyr Lys
      55                  60                  65

 aat gca gat gtc aga cct cca ttt act tat gca act ctc ata agg cag      533
 Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Gln
  70                  75                  80                  85

 gct atc atg gag tca tct gac agg cag tta aca ctt aat gaa att tac      581
 Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr
                  90                  95                 100

 agc tgg ttt aca cgg aca ttt gct tac ttc agg cgt aat gca gca act      629
 Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr
             105                 110                 115

 tgg aag aat gca gta cgt cat aat ctt agc ctg cac aag tgt ttt gtt      677
 Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val
         120                 125                 130

 cga gta gaa aat gtt aaa gga gca gta tgg act gtg gat gaa gta gaa      725
 Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu
     135                 140                 145

 tac cag aag cga agg tca caa aag ata aca gga agt cca acc tta gta      773
 Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr Leu Val
 150                 155                 160                 165

 aaa aat ata cct acc agt tta ggc tat gga gca gct ctt aat gcc agt      821
 Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn Ala Ser
                 170                 175                 180

 ttg cag gct gcc ttg gca gag agc agt tta cct ttg cta agt aat cct      869
 Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser Asn Pro
             185                 190                 195

 gga ctg ata aat aat gca tcc agt ggc cta ctg cag gcc gtc cac gaa      917
 Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala Val His Glu
         200                 205                 210

 gac ctc aat ggt tct ctg gat cac att gac agc aat gga aac agt agt      965
 Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly Asn Ser Ser
     215                 220                 225

 ccg ggc tgc tca cct cag ccg cac ata cat tca atc cac gtc aag gaa     1013
 Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His Val Lys Glu
 230                 235                 240                 245

 gag cca gtg att gca gag gat gaa gac tgc cca atg tcc tta gtg aca     1061
 Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser Leu Val Thr
                 250                 255                 260

 aca gct aat cac agt cca gaa tta gaa gac gac aga gag att gaa gaa     1109
 Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile Glu Glu
             265                 270                 275

 gag cct tta tct gaa gat ctg gaa tga gaact gacttgtgaa acctcagcgt     1161
 Glu Pro Leu Ser Glu Asp Leu Glu 
         280                 285

 gaagggacat atcactgacc tttataac                                      1189




      <210> 405
      <211> 739
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(509)

      <400> 405
 cgctccggaa ttctccgggt tcccgggtcg acccacgcgt ccgcgacctt atccagccac     60

 acgccacc atg tgt cat acc agc tgc tcc tcg ggc tgc cag cca gcc tgc     110
          Met Cys His Thr Ser Cys Ser Ser Gly Cys Gln Pro Ala Cys
            1               5                  10

 tgc gcg ccc agc ccc tgc cag cca gcc tgt tgt gtg ccc agc tcc tgc      158
 Cys Ala Pro Ser Pro Cys Gln Pro Ala Cys Cys Val Pro Ser Ser Cys
  15                  20                  25                  30

 cag gca tcc tgc tgt gtg cct gtg ggc tgc cag tcc tcc gtg tgt gtg      206
 Gln Ala Ser Cys Cys Val Pro Val Gly Cys Gln Ser Ser Val Cys Val
                  35                  40                  45

 ccc gtg agc ttc aag cca gcc gtg tgc ctg ccc gtg agc tgc cag tct      254
 Pro Val Ser Phe Lys Pro Ala Val Cys Leu Pro Val Ser Cys Gln Ser
              50                  55                  60

 tct gtg tgt gtg ccc atg agc ttc aag tca gct gtg tgc gtg ccc gtg      302
 Ser Val Cys Val Pro Met Ser Phe Lys Ser Ala Val Cys Val Pro Val
          65                  70                  75

 agc tgc cag tct tct gtg tgt gtg cct gtg agc tgc agg ccc att gtg      350
 Ser Cys Gln Ser Ser Val Cys Val Pro Val Ser Cys Arg Pro Ile Val
      80                  85                  90

 tgt gca gcc ccc tcc tgc cag tcc tcc ctg tgc gtg cct gtg agc tgc      398
 Cys Ala Ala Pro Ser Cys Gln Ser Ser Leu Cys Val Pro Val Ser Cys
  95                 100                 105                 110

 agg cct gtc gtg tat gcg gct ccg tcc tgc cag tcc tct ggg tgc tgc      446
 Arg Pro Val Val Tyr Ala Ala Pro Ser Cys Gln Ser Ser Gly Cys Cys
                 115                 120                 125

 cag ccc tcc tgc acc agc gtc ccc tgc aga ccc atc tcc tac agt atc      494
 Gln Pro Ser Cys Thr Ser Val Pro Cys Arg Pro Ile Ser Tyr Ser Ile
             130                 135                 140

 tct tcc tgc tgc tga gcatgaatct ccagacccgc tgctcccagt gcagatgagg      549
 Ser Ser Cys Cys 
         145

 ccacacctgt acactccctg gatgagtcct cagttggtct tctgcacatg gtgcaggtga    609

 aaagcatgct cagttgaacc ctctgaattc tggattgaga atgtgacaga atgatctgga    669

 gcccttgctg accttgccca tccccccagg gaagtctggg gtcccagagt cacccgggaa    729

 ttccgcgccg                                                           739




      <210> 406
      <211> 963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (212)..(661)

      <400> 406
 tagaccgctc tgggcgcccc gatcttgccg atgctgtcag gctccaagag cgcgcacggc     60

 tcgctggacc gcccgaaggc catgagctgg tccgggacca cgtgcaccgc gatgtactgg    120

 gggggcttgc cggtggcctg cgccagctgc tgggtgagct cggagaggaa cccgtccggc    180

 acaggaggcg cggggcacgt tggtgtttac g   atg aac atc ggc atg atg gca     232
                                      Met Asn Ile Gly Met Met Ala
                                        1               5

 aga agg aca cag gag acc cgc gca gag gca cag acg cac gcg ccg cgg      280
 Arg Arg Thr Gln Glu Thr Arg Ala Glu Ala Gln Thr His Ala Pro Arg
          10                  15                  20

 ccg ccg ctg agc tac gtg cct gac ttc tcg gac acc act gtg gtc ccg      328
 Pro Pro Leu Ser Tyr Val Pro Asp Phe Ser Asp Thr Thr Val Val Pro
      25                  30                  35

 cct ttt gtg acg cca ccg ccg gcg cca ggc ccc gcc ccc gcg agg ctg      376
 Pro Phe Val Thr Pro Pro Pro Ala Pro Gly Pro Ala Pro Ala Arg Leu
  40                  45                  50                  55

 cgg ctc cgc ccc gag tgg gga agt cac cgc ctg cct cgg ctc gac ccc      424
 Arg Leu Arg Pro Glu Trp Gly Ser His Arg Leu Pro Arg Leu Asp Pro
                  60                  65                  70

 cgc agg gca gga ccc tgg gcg act ccg ccc gtt cct cca gca acc gcc      472
 Arg Arg Ala Gly Pro Trp Ala Thr Pro Pro Val Pro Pro Ala Thr Ala
              75                  80                  85

 gct aag ccc ggc gca ccg ctc caa cct gtt ctc cac ttg gcg gct aga      520
 Ala Lys Pro Gly Ala Pro Leu Gln Pro Val Leu His Leu Ala Ala Arg
          90                  95                 100

 aat cgg cct gtt ccg gcc tcg cct cgg gtc ttt ctt agt cct ttc act      568
 Asn Arg Pro Val Pro Ala Ser Pro Arg Val Phe Leu Ser Pro Phe Thr
     105                 110                 115

 aag tca ccg atg tta gtc gcc agg agg cgc tgt gcc ggg ggt ggg gat      616
 Lys Ser Pro Met Leu Val Ala Arg Arg Arg Cys Ala Gly Gly Gly Asp
 120                 125                 130                 135

 gcg gcg gtg aac ccg gaa gat ggc ccc tta ccc ttc cag aga tga agc      664
 Ala Ala Val Asn Pro Glu Asp Gly Pro Leu Pro Phe Gln Arg 
                 140                 145

 ccagttcatt ccactgcacg cactgagccc ctgtacctcc tgtctttggg ccacatgtcc    724

 tcaagggctc cagtcccgca tgcgtgagct tgtgtgtttg agatggggcg gggtagtcat    784

 cgcggcaggt gagaggggag ctgcccctgc gaatcaccat ccagggaact tccctgaacc    844

 cctgctcttt aaagaggata ggatgctggg aggcaccgaa gggaaggagg cgaggtccag    904

 agcaggttca gtggttcaaa cgtgctcagc tccccttctc tgggccctct gggcaactt     963




      <210> 407
      <211> 543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(281)

      <400> 407
 aaggcgctta aggatttgtt ttctaagtta catgtgtatc ttcctgaaaa ctgtcttccc     60

 tttttggtgg ttttataagc aacataaaga gcaataatgt actaggtgag ataatggtca    120

 gtaagtaata tttagaattc taaaggaaaa aatgctctta gagttagtag   atg agt     176
                                                          Met Ser
                                                            1

 cga atc aac aag tat tta ttt agt aat tct gat tct aac ttt agt cat      224
 Arg Ile Asn Lys Tyr Leu Phe Ser Asn Ser Asp Ser Asn Phe Ser His
           5                  10                  15

 ttt tct gtc tca aat gtg agt aca tac tgt gtg cca ggt aat aag gat      272
 Phe Ser Val Ser Asn Val Ser Thr Tyr Cys Val Pro Gly Asn Lys Asp
      20                  25                  30

 aca aat tga acataat aaacatccct gtcgatctta tagggaactt acactgtatt      328
 Thr Asn 
  35

 agaggagaca gatacctaaa acaagtgctg aagtgtgaca agatggaaaa taagtgattg    388

 gtgaatgaag tgctgagtag gataaattaa tgggaaattg aagcagggag gattaattta    448

 gagtaattaa aatgttagtg ccctaaaggt agaaaaacta aatcaaagta agacatggca    508

 ggggtgcaaa tattaagttt aatactttga aacgt                               543




      <210> 408
      <211> 540
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(413)

      <400> 408
 aaataaataa ataaataaat aaataaataa ataagtgaac cacgcagggt ccttccgggg     60

 ggtgaccttc agctggccat tcgggatgat ggactttcca tcccagaacc   atg gct     116
                                                          Met Ala
                                                            1

 cca ttt gtc cgt aac ctt gtg gag aag acc cca gca ctg gtg aat gct      164
 Pro Phe Val Arg Asn Leu Val Glu Lys Thr Pro Ala Leu Val Asn Ala
           5                  10                  15

 gct gtg act tac ttg aag cct cga ttg gcc gca ttt tgg tac tac acc      212
 Ala Val Thr Tyr Leu Lys Pro Arg Leu Ala Ala Phe Trp Tyr Tyr Thr
      20                  25                  30

 acg gtt gag ctg gtt cct ccc acc cct gct gag atc cct aga gct att      260
 Thr Val Glu Leu Val Pro Pro Thr Pro Ala Glu Ile Pro Arg Ala Ile
  35                  40                  45                  50

 cag agc ctg aaa aaa ata gtc agt agt gct cag act ggt agc ttc aaa      308
 Gln Ser Leu Lys Lys Ile Val Ser Ser Ala Gln Thr Gly Ser Phe Lys
                  55                  60                  65

 cag ctc aca gtt aag gaa gct ttg ctg aac ggt ttg gtg gcc act gag      356
 Gln Leu Thr Val Lys Glu Ala Leu Leu Asn Gly Leu Val Ala Thr Glu
              70                  75                  80

 gtg tcg acg tgg ttt tat gtc aga gag atc aca ggc aag cgt ggc atc      404
 Val Ser Thr Trp Phe Tyr Val Arg Glu Ile Thr Gly Lys Arg Gly Ile
          85                  90                  95

 att ggc tag aatgttt gaagaccagt cttaacatct gattatattt gatttattat      460
 Ile Gly 
     100

 ttgagtgttg ttggaccagg tgtgatcaga ctgctacctg aataaaataa gatttgtcag    520

 aaattccaaa aaaaaaaaaa                                                540




      <210> 409
      <211> 2801
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(2446)

      <400> 409
 tgctccggaa tttccgggtc gacgatttcg tccggcacct atctgccact cccaaagg       58                                                                 
 atg ccc gtg gcc gag gcc ccc cag gtg gct ggc ggg cag ggg gac gga      106
 Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly
   1               5                  10                  15

 ggt gat ggc gag gaa gcg gag ccg gag ggg atg ttc aag gcc tgt gag      154
 Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu
              20                  25                  30

 gac tcc aag aga aaa gcc cgg ggc tac ctc cgc ctg gtg ccc ctg ttt      202
 Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe
          35                  40                  45

 gtg ctg ctg gcc ctg ctc gtg ctg gct tcg gcg ggg gtg cta ctc tgg      250
 Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp
      50                  55                  60

 tat ttc cta ggg tac aag gcg gag gtg atg gtc agc cag gtg tac tca      298
 Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser
  65                  70                  75                  80

 ggc agt ctg cgt gta ctc aat cgc cac ttc tcc cag gat ctt acc cgc      346
 Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg
                  85                  90                  95

 cgg gaa tct agt gcc ttc cgc agt gaa acc gcc aaa gcc cag aag atg      394
 Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met
             100                 105                 110

 ctc aag gag ctc atc acc agc acc cgc ctg gga act tac tac aac tcc      442
 Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser
         115                 120                 125

 agc tcc gtc tat tcc ttt ggg gag gga ccc ctc acc tgc ttc ttc tgg      490
 Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp
     130                 135                 140

 ttc att ctc caa atc ccc gag cac cgc cgg ctg atg ctg agc ccc gag      538
 Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu
 145                 150                 155                 160

 gtg gtg cag gca ctg ctg gtg gag gag ctg ctg tcc aca gtc aac agc      586
 Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser
                 165                 170                 175

 tcg gct gcc gtc ccc tac agg gcc gag tac gaa gtg gac ccc gag ggc      634
 Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly
             180                 185                 190

 cta gtg atc ctg ggt cag tac tgc gag tgg aaa cgt tgt tac cgc tac      682
 Leu Val Ile Leu Gly Gln Tyr Cys Glu Trp Lys Arg Cys Tyr Arg Tyr
         195                 200                 205

 agc tac gtg ggc cag ggc cag gtc ctc cgg ctg aag ggg cct gac cac      730
 Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His
     210                 215                 220

 ctg gcc tcc agc tgc ctg tgg cac ctg cag ggc ccc aag gac ctc atg      778
 Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met
 225                 230                 235                 240

 ctc aaa ctc cgg ctg gag tgg acg ctg gca gag tgc cgg gac cga ctg      826
 Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu
                 245                 250                 255

 gcc atg tat gac gtg gcc ggg ccc ctg gag aag agg ctc atc acc tcg      874
 Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser
             260                 265                 270

 gtg tac ggc tgc agc cgc cag gag ccc gtg gtg gag gtt ctg gcg tcg      922
 Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser
         275                 280                 285

 ggg gcc atc atg gcg gtc gtc tgg aag aag ggc ctg cac agc tac tac      970
 Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr
     290                 295                 300

 gac ccc ttc gtg ctc tcc gtg cag ccg gtg gtc ttc cag gcc tgt gaa     1018
 Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu
 305                 310                 315                 320

 gtg aac ctg acg ctg gac aac agg ctc gac tcc cag ggc gtc ctc agc     1066
 Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser
                 325                 330                 335

 acc ccg tac ttc ccc agc tac tac tcg ccc caa acc cac tgc tcc tgg     1114
 Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp
             340                 345                 350

 cac ctc acg gtg ccc tct ctg gac tac ggc ttg gcc ctc tgg ttt gat     1162
 His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp
         355                 360                 365

 gcc tat gca ctg agg agg cag aag tat gat ttg ccg tgc acc cag ggc     1210
 Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly
     370                 375                 380

 cag tgg acg atc cag aac agg agg ctg tgt ggc ttg cgc atc ctg cag     1258
 Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln
 385                 390                 395                 400

 ccc tac gcc gag agg atc ccc gtg gtg gcc acg gcc ggg atc acc atc     1306
 Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile
                 405                 410                 415

 aac ttc acc tcc cag atc tcc ctc acc ggg ccc ggt gtg cgg gtg cac     1354
 Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His
             420                 425                 430

 tat ggc ttg tac aac cag tcg gac ccc tgc cct gga gag ttc ctc tgt     1402
 Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys
         435                 440                 445

 tct gtg aat gga ctc tgt gtc cct gcc tgt gat ggg gtc aag gac tgc     1450
 Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys
     450                 455                 460

 ccc aac ggc ctg gat gag aga aac tgc gtt tgc aga gcc aca ttc cag     1498
 Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln
 465                 470                 475                 480

 tgc aaa gag gac agc aca tgc atc tca ctg ccc aag gtc tgt gat ggg     1546
 Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly
                 485                 490                 495

 cag cct gat tgt ctc aac ggc agc gac gaa gag cag tgc cag gaa ggg     1594
 Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly
             500                 505                 510

 gtg cca tgt ggg aca ttc acc ttc cag tgt gag gac cgg agc tgc gtg     1642
 Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val
         515                 520                 525

 aag aag ccc aac ccg cag tgt gat ggg cgg ccc gac tgc agg gac ggc     1690
 Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly
     530                 535                 540

 tcg gat gag gag cac tgt gac tgt ggc ctc cag ggc ccc tcc agc cgc     1738
 Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg
 545                 550                 555                 560

 att gtt ggt gga gct gtg tcc tcc gag ggt gag tgg cca tgg cag gcc     1786
 Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala
                 565                 570                 575

 agc ctc cag gtt cgg ggt cga cac atc tgt ggg ggg gcc ctc atc gct     1834
 Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala
             580                 585                 590

 gac cgc tgg gtg ata aca gct gcc cac tgc ttc cag gag gac agc atg     1882
 Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met
         595                 600                 605

 gcc tcc acg gtg ctg tgg acc gtg ttc ctg ggc aag gtg tgg cag aac     1930
 Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn
     610                 615                 620

 tcg cgc tgg cct gga gag gtg tcc ttc aag gtg agc cgc ctg ctc ctg     1978
 Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu
 625                 630                 635                 640

 cac ccg tac cac gaa gag gac agc cat gac tac gac gtg gcg ctg ctg     2026
 His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu
                 645                 650                 655

 cag ctc gac cac ccg gtg gtg cgc tcg gcc gcc gtg cgc ccc gtc tgc     2074
 Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys
             660                 665                 670

 ctg ccc gcg cgc tcc cac ttc ttc gag ccc ggc ctg cac tgc tgg att     2122
 Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile
         675                 680                 685

 acg ggc tgg ggc gcc ttg cgc gag ggc ggc ccc atc agc aac gct ctg     2170
 Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu
     690                 695                 700

 cag aaa gtg gat gtg cag ttg atc cca cag gac ctg tgc agc gag gtc     2218
 Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val
 705                 710                 715                 720

 tat cgc tac cag gtg acg cca cgc atg ctg tgt gcc ggc tac cgc aag     2266
 Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys
                 725                 730                 735

 ggc aag aag gat gcc tgt cag ggt gac tca ggt ggt ccg ctg gtg tgc     2314
 Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys
             740                 745                 750

 aag gca ctc agt ggc cgc tgg ttc ctg gcg ggg ctg gtc agc tgg ggc     2362
 Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly
         755                 760                 765

 ctg ggc tgt ggc cgg cct aac tac ttc ggc gtc tac acc cgc atc aca     2410
 Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr
     770                 775                 780

 ggt gtg atc agc tgg atc cag caa gtg gtg acc tga ggaa ctgcccccct     2460
 Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr 
 785                 790                 795

 gcaaagcagg gcccacctcc tggactcaga gagcccaggg caactgccaa gcagggggac   2520

 aagtattctg gcggggggtg ggggagagag caggccctgt ggtggcagga ggtggcatct   2580

 tgtctcgtcc ctgatgtctg ctccagtgat ggcaggagga tggagaagtg ccagcagctg   2640

 ggggtcaaga cgtcccctga ggacccaggc ccacacccag cccttctgcc tcccaattct   2700

 ctctcctccg tccccttcct ccactgctgc ctaatgcaag gcagtggctc agcagcaaga   2760

 atgctggttc tacatcccga ggagtgtctg aggtgcgccc c                       2801




      <210> 410
      <211> 1074
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (219)..(992)

      <400> 410
 atttggccct cgaggccaac aattcggcac gagcggcacg aggaagctct ttccactacg     60

 ggtgtattgc actggtgagt ccgggcccat ggatgagaaa ttgatgcgag gatcaataca    120

 agcttaattt gaattaataa aaggaaatat tttctccctt tgaacttatc tccgtaaagc    180

 cattgtgcct cctcttgggg gtcacgtgtt cacaatca    atg gcc ttt gag gag     233
                                              Met Ala Phe Glu Glu
                                                1               5

 ctc ttg agt caa gtt gga ggc ctt ggg aga ttt cag atg ctt cat ctg      281
 Leu Leu Ser Gln Val Gly Gly Leu Gly Arg Phe Gln Met Leu His Leu
                  10                  15                  20

 gtt ttt att ctt ccc tct ctc atg tta tta atc cct cat ata ctg cta      329
 Val Phe Ile Leu Pro Ser Leu Met Leu Leu Ile Pro His Ile Leu Leu
              25                  30                  35

 gag aac ttt gct gca gcc att cct ggt cat cgt tgc tgg gtc cac atg      377
 Glu Asn Phe Ala Ala Ala Ile Pro Gly His Arg Cys Trp Val His Met
          40                  45                  50

 ctg gac aat aat act gga tct ggt aat gaa act gga atc ctc agt gaa      425
 Leu Asp Asn Asn Thr Gly Ser Gly Asn Glu Thr Gly Ile Leu Ser Glu
      55                  60                  65

 gat gcc ctc ttg aga atc tct atc cca cta gac tca aat ctg agg cca      473
 Asp Ala Leu Leu Arg Ile Ser Ile Pro Leu Asp Ser Asn Leu Arg Pro
  70                  75                  80                  85

 gag aag tgt cgt cgc ttt gtc cat ccc cag tgg cag ctt ctt cac ctg      521
 Glu Lys Cys Arg Arg Phe Val His Pro Gln Trp Gln Leu Leu His Leu
                  90                  95                 100

 aat ggg act atc cac agc aca agt gag gca gac aca gaa ccc tgt gtg      569
 Asn Gly Thr Ile His Ser Thr Ser Glu Ala Asp Thr Glu Pro Cys Val
             105                 110                 115

 gat ggc tgg gta tat gat caa agc tac ttc cct tcg acc att gtg act      617
 Asp Gly Trp Val Tyr Asp Gln Ser Tyr Phe Pro Ser Thr Ile Val Thr
         120                 125                 130

 aag ttg gac ctg gta tgt gat tat cag tca ctg aaa tca gtg gtt caa      665
 Lys Leu Asp Leu Val Cys Asp Tyr Gln Ser Leu Lys Ser Val Val Gln
     135                 140                 145

 ttc cta ctt ctg act gga atg ctg gtg gga ggc atc ata ggt ggc cat      713
 Phe Leu Leu Leu Thr Gly Met Leu Val Gly Gly Ile Ile Gly Gly His
 150                 155                 160                 165

 gtc tca gac agg tgg ctg gtg gaa tct gct cgg tgg ttg ata atc acc      761
 Val Ser Asp Arg Trp Leu Val Glu Ser Ala Arg Trp Leu Ile Ile Thr
                 170                 175                 180

 aat aaa cta gat gag ggc tta aag gca ctt aga aaa gtt gca cgc aca      809
 Asn Lys Leu Asp Glu Gly Leu Lys Ala Leu Arg Lys Val Ala Arg Thr
             185                 190                 195

 aat gga ata aag aat gct gaa gaa acc ctg aac ata gag gtt gta aga      857
 Asn Gly Ile Lys Asn Ala Glu Glu Thr Leu Asn Ile Glu Val Val Arg
         200                 205                 210

 tcc acc atg cag gag gag ctg gat gca gca cag acc aaa act act gtg      905
 Ser Thr Met Gln Glu Glu Leu Asp Ala Ala Gln Thr Lys Thr Thr Val
     215                 220                 225

 tgt gac ttg ttc cgc aac ccc agt atg cgt aaa agg atc tgt atc ctg      953
 Cys Asp Leu Phe Arg Asn Pro Ser Met Arg Lys Arg Ile Cys Ile Leu
 230                 235                 240                 245

 gta ttt ttg aga aaa aaa aat ctc aag gaa aag gca taa aaatgattgc      1002
 Val Phe Leu Arg Lys Lys Asn Leu Lys Glu Lys Ala 
                 250                 255

 tacacaaaag tgaccaaatt ttaagaagcc ttcatgagct gattggtggg gaaattcaga   1062

 aaaaaaaaaa aa                                                       1074




      <210> 411
      <211> 953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (170)..(436)

      <400> 411
 catttccggt tcgacccacg cgtccgcttc agaccacacc tctggtggga ggtgctgcgt     60

 gatgtttttt gggtgaactg agtcaggtca gaggagcagg gagccccagc ccctggtgtc    120

 ttcttactgt gtggtctctt ccgtgtcacc gcacttctgt ggaagggga    atg atg     175
                                                          Met Met
                                                            1

 ggg gaa gtg gag gaa cca ctg tcc gcc tgc gga ggg gcc tca gtg ttg      223
 Gly Glu Val Glu Glu Pro Leu Ser Ala Cys Gly Gly Ala Ser Val Leu
           5                  10                  15

 gcc gtg ctc atg gcg ccc tcc tcc tgg ggc tcc ctc tcc tct ggt cct      271
 Ala Val Leu Met Ala Pro Ser Ser Trp Gly Ser Leu Ser Ser Gly Pro
      20                  25                  30

 gcc tct cct gca cgc cct tcc tgc ctc ctt ggt gcc agg gga gcc agc      319
 Ala Ser Pro Ala Arg Pro Ser Cys Leu Leu Gly Ala Arg Gly Ala Ser
  35                  40                  45                  50

 cca gga cag tct ctg tgc cta ggc cct gcc agc ctg gct gcc ctg cct      367
 Pro Gly Gln Ser Leu Cys Leu Gly Pro Ala Ser Leu Ala Ala Leu Pro
                  55                  60                  65

 cca gcc atg ggg ggc agg cgg gga ggg agt cga cca gtg ctt gtc ttt      415
 Pro Ala Met Gly Gly Arg Arg Gly Gly Ser Arg Pro Val Leu Val Phe
              70                  75                  80

 gca gaa ctg ctg gtg gac tga at gtggttctgg gggtggccag gcctgagggt      468
 Ala Glu Leu Leu Val Asp 
          85

 aactcatttt ggaaggtttg ggatgtcact tcacttaagg agccttcagc aacatggagt    528

 ttaagtggcc ctcttcactg tggccttgtg gcttcatgaa tggagctgct gtggtcagca    588

 tggctggccc tctggagagg agggtgggcc atgaggagaa gatgctgtgt ctggaggcct    648

 taaccctttc ctcccttctc tccctccctc cctcctgtct ctttctctct ctgtctcttt    708

 ctctctaggt gcataaaaaa aattgctttc agataaagtt gacatgcaat acactgcagt    768

 attctccctg tcgcttttaa aatgataatc tgtttcagcc atgcaaagca gggtataaaa    828

 taatatttca gtgtaaccag ctcagcggaa gaaataaacc attccagttg caatacctga    888

 tgtaccgttc tctgatttca aacccttcct ttttctctgc cccgactttg atgtttattc    948

 ttgtg                                                                953




      <210> 412
      <211> 478
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(342)

      <400> 412
 attttgccct cgaggccaag aattcggcac gaggcagctc ctgagactgc tggc  atg      57
                                                              Met
                                                                1

 aag ggg agc cgt gcc ctc ctg ctg gtg gcc ctc acc ctg ttc tgc atc      105
 Lys Gly Ser Arg Ala Leu Leu Leu Val Ala Leu Thr Leu Phe Cys Ile
               5                  10                  15

 tgc cgg atg gcc aca ggg gag gac aac gat gag ttt ttc atg gac ttc      153
 Cys Arg Met Ala Thr Gly Glu Asp Asn Asp Glu Phe Phe Met Asp Phe
          20                  25                  30

 ctg caa aca cta ctg gtg ggg acc cca gag gag ctc tat gag ggg acc      201
 Leu Gln Thr Leu Leu Val Gly Thr Pro Glu Glu Leu Tyr Glu Gly Thr
      35                  40                  45

 ttg ggc aag tac aat gtc aac gaa gat gcc aag gca gca atg act gaa      249
 Leu Gly Lys Tyr Asn Val Asn Glu Asp Ala Lys Ala Ala Met Thr Glu
  50                  55                  60                  65

 ctc aag tcc tgc aga gat ggc ctg cag cca atg cac aag gcg gag ctg      297
 Leu Lys Ser Cys Arg Asp Gly Leu Gln Pro Met His Lys Ala Glu Leu
                  70                  75                  80

 gtc aag ctg ctg gtg caa gtg ctg ggc agt cag gac ggt gcc taa gtg      345
 Val Lys Leu Leu Val Gln Val Leu Gly Ser Gln Asp Gly Ala 
              85                  90                  95

 gacctcagac atggctcagc cataggacct gccacacaag cagccgtgga cacaacgccc    405

 actaccacct cccacatgga aatgtatcct caaaccgttt aatcaataaa gcctcttccg    465

 caaaaaaaaa aaa                                                       478




      <210> 413
      <211> 562
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (341)..(562)

      <400> 413
 cttgcggcca tttaaaataa aagtagatca gaagtaattt gttacattag agaattaagg     60

 ggggaagtct acttatattt actaaacaca tgatgtgctt gacactgtgc tattccactt    120

 aaccactctg tgaggtaaat attgttattg ctattttaca aacaagaaaa tgaaaaaaaa    180

 ttgtgcccag atggccttcc agagacagcc ccaataagac ctctcagccc atatattctt    240

 ctgcaatgtg accttcccac ttcctttaaa gacatgcagt ttatttctca agccccttga    300

 atctgggagg ccctgtgact tctttaatag atacaatact  atg cca gtt cca aag     355
                                              Met Pro Val Pro Lys
                                                1               5

 ccc tta act gcc tgg caa ctt cta ctt cct aac tct tgg aac cct gag      403
 Pro Leu Thr Ala Trp Gln Leu Leu Leu Pro Asn Ser Trp Asn Pro Glu
                  10                  15                  20

 cag cca cat aag ttt agg cta ctc tgc tgg ata aag agg cca tct caa      451
 Gln Pro His Lys Phe Arg Leu Leu Cys Trp Ile Lys Arg Pro Ser Gln
              25                  30                  35

 aga gca ctg aga cat cag aca agt aaa agg aaa aca cca tct tgg atc      499
 Arg Ala Leu Arg His Gln Thr Ser Lys Arg Lys Thr Pro Ser Trp Ile
          40                  45                  50

 cag cct agg gca gag tct tca gat ggc ccc atc tcc agg tac tat ctg      547
 Gln Pro Arg Ala Glu Ser Ser Asp Gly Pro Ile Ser Arg Tyr Tyr Leu
      55                  60                  65

 acc aca acc aca tga                                                  562
 Thr Thr Thr Thr 
  70





      <210> 414
      <211> 1269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(1164)

      <220>
      <221> misc_feature
      <222> (1)...(1269)
      <223> n = a,t,c or g

      <400> 414
 caggacagtg ggggtctcct ccgtcctggc gtagttctgg gagccgngcc ctcgctcctc     60

 cctgggatgg ggctgccgct tctccgccgg acttaagtcg ggccctgttg cctcagtact    120

 ggagtgcaga gctgaattcg ggccactttg tcttttccac agcctgtgct cactgccaag    180

 gggaca   atg acg gcc tcc agt gtc ctc ctg cac act gga cag aag atg     228
          Met Thr Ala Ser Ser Val Leu Leu His Thr Gly Gln Lys Met
            1               5                  10

 cct ctg att ggt ctg ggg aca tgg aag agt gag cct ggt cag gtg aaa      276
 Pro Leu Ile Gly Leu Gly Thr Trp Lys Ser Glu Pro Gly Gln Val Lys
  15                  20                  25                  30

 gca gcc att aaa cat gcc ctt agc gca ggc tac cgc cac att gat tgt      324
 Ala Ala Ile Lys His Ala Leu Ser Ala Gly Tyr Arg His Ile Asp Cys
                  35                  40                  45

 gct tct gta tat ggc aat gaa act gag att ggg gag gcc ctg aag gag      372
 Ala Ser Val Tyr Gly Asn Glu Thr Glu Ile Gly Glu Ala Leu Lys Glu
              50                  55                  60

 agt gtg ggg tca ggc aag gca gtc cct cga gag gag ctg ttt gtg aca      420
 Ser Val Gly Ser Gly Lys Ala Val Pro Arg Glu Glu Leu Phe Val Thr
          65                  70                  75

 tcc aag ctg tgg aat act aag cac cac cct gag gat gta gaa cct gcc      468
 Ser Lys Leu Trp Asn Thr Lys His His Pro Glu Asp Val Glu Pro Ala
      80                  85                  90

 ctc cgg aag aca ctg gct gat ctg caa ctg gag tat ttg gac ctc tat      516
 Leu Arg Lys Thr Leu Ala Asp Leu Gln Leu Glu Tyr Leu Asp Leu Tyr
  95                 100                 105                 110

 ttg atg cac tgg cct tat gcc ttt gag cgg gga gac aat ccc ttt ccc      564
 Leu Met His Trp Pro Tyr Ala Phe Glu Arg Gly Asp Asn Pro Phe Pro
                 115                 120                 125

 aag aat gcc gat gga act gtc aga tat gac tca act cac tat aaa gag      612
 Lys Asn Ala Asp Gly Thr Val Arg Tyr Asp Ser Thr His Tyr Lys Glu
             130                 135                 140

 acc tgg aag gct ctg gag gta ctg gtg gca aag ggg ctg gtg aaa gcc      660
 Thr Trp Lys Ala Leu Glu Val Leu Val Ala Lys Gly Leu Val Lys Ala
         145                 150                 155

 ctg ggc ttg tcc aac ttc aac agt cgg cag att gat gat gtc ctc agt      708
 Leu Gly Leu Ser Asn Phe Asn Ser Arg Gln Ile Asp Asp Val Leu Ser
     160                 165                 170

 gtg gcc tct gtg cgc cca gct gtc ttg cag gtg gaa tgc cat cca tac      756
 Val Ala Ser Val Arg Pro Ala Val Leu Gln Val Glu Cys His Pro Tyr
 175                 180                 185                 190

 ctg gct cag aat gag ctc att gcc cac tgt cac gca cgg ggc ttg gag      804
 Leu Ala Gln Asn Glu Leu Ile Ala His Cys His Ala Arg Gly Leu Glu
                 195                 200                 205

 gtg act gct tat agc ccc ttg ggt tcc tct gac cgt gct tgg cgc cat      852
 Val Thr Ala Tyr Ser Pro Leu Gly Ser Ser Asp Arg Ala Trp Arg His
             210                 215                 220

 cct gat gag cca gtc ctg ctt gaa gaa cca gta gtc ttg gca cta gct      900
 Pro Asp Glu Pro Val Leu Leu Glu Glu Pro Val Val Leu Ala Leu Ala
         225                 230                 235

 gaa aaa cat ggc cga tct cca gct cag atc ttg ctt aga tgg cag gtt      948
 Glu Lys His Gly Arg Ser Pro Ala Gln Ile Leu Leu Arg Trp Gln Val
     240                 245                 250

 cag cgg aaa gtg atc tgc atc ccc aaa agc atc aat cct tcc cgc atc      996
 Gln Arg Lys Val Ile Cys Ile Pro Lys Ser Ile Asn Pro Ser Arg Ile
 255                 260                 265                 270

 ctt cag aac att cag gta ttt gat ttc acc ttt agc cca gag gag atg     1044
 Leu Gln Asn Ile Gln Val Phe Asp Phe Thr Phe Ser Pro Glu Glu Met
                 275                 280                 285

 aaa caa tta gat gct ctg aac aaa aat tgg cgg tat att gtg ccc atg     1092
 Lys Gln Leu Asp Ala Leu Asn Lys Asn Trp Arg Tyr Ile Val Pro Met
             290                 295                 300

 att acg gtg gat ggg aag agg gtt ccc aga gat gct gga cac cct ctg     1140
 Ile Thr Val Asp Gly Lys Arg Val Pro Arg Asp Ala Gly His Pro Leu
         305                 310                 315

 tat ccc ttt aat gac cca tac tga gacctatagt ttctcagctt ccctttcagt    1194
 Tyr Pro Phe Asn Asp Pro Tyr 
     320                 325

 tctcctgcta agcattgcct gctactcccc agaaagaagg aatcaataaa gccattgaag   1254

 tgtaaaaaaa aaaaa                                                    1269




      <210> 415
      <211> 5816
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(3609)

      <400> 415
 aagtcacgtg ctgtgacagt agctggggtg aggccgtcgt cgccgcacgg gctggttggg     60

 gctgtgtctg tgggaggcgc cggggtg    atg gcg gtg gag act ctg tcc ccg     111
                                  Met Ala Val Glu Thr Leu Ser Pro
                                    1               5

 gac tgg gag ttt gac cgc gtt gac gac ggc tcg cag aaa att cat gcc      159
 Asp Trp Glu Phe Asp Arg Val Asp Asp Gly Ser Gln Lys Ile His Ala
      10                  15                  20

 gaa gtc caa ctt aag aat tat ggg aaa ttt ctt gag gag tat acc tct      207
 Glu Val Gln Leu Lys Asn Tyr Gly Lys Phe Leu Glu Glu Tyr Thr Ser
  25                  30                  35                  40

 caa ctg aga aga att gag gac gct ctg gat gac tca att gga gat gtt      255
 Gln Leu Arg Arg Ile Glu Asp Ala Leu Asp Asp Ser Ile Gly Asp Val
                  45                  50                  55

 tgg gat ttc aat ctt gat cct ata gca tta aag ctt ttg cct tat gaa      303
 Trp Asp Phe Asn Leu Asp Pro Ile Ala Leu Lys Leu Leu Pro Tyr Glu
              60                  65                  70

 cag tcc tct ctt ttg gaa ctc ata aag act gaa aac aag gtc tta aac      351
 Gln Ser Ser Leu Leu Glu Leu Ile Lys Thr Glu Asn Lys Val Leu Asn
          75                  80                  85

 aaa gtc atc act gtt tat gct gca ctt tgt tgt gaa atc aag aaa tta      399
 Lys Val Ile Thr Val Tyr Ala Ala Leu Cys Cys Glu Ile Lys Lys Leu
      90                  95                 100

 aaa tat gag gct gaa act aaa ttt tac aat ggt ctc ttg ttt tat gga      447
 Lys Tyr Glu Ala Glu Thr Lys Phe Tyr Asn Gly Leu Leu Phe Tyr Gly
 105                 110                 115                 120

 gaa gga gct aca gat gcc agc atg gtg gaa ggt gat tgc caa att caa      495
 Glu Gly Ala Thr Asp Ala Ser Met Val Glu Gly Asp Cys Gln Ile Gln
                 125                 130                 135

 atg ggg aga ttt att tca ttc tta cag gaa ctg tct tgc ttt gtt acg      543
 Met Gly Arg Phe Ile Ser Phe Leu Gln Glu Leu Ser Cys Phe Val Thr
             140                 145                 150

 agg tgc tat gaa gtg gtg atg aac gta gtc cac cag ttg gct gcc ctc      591
 Arg Cys Tyr Glu Val Val Met Asn Val Val His Gln Leu Ala Ala Leu
         155                 160                 165

 tat atc agt aac aag att gca ccc aaa att ata gag aca act gga gtt      639
 Tyr Ile Ser Asn Lys Ile Ala Pro Lys Ile Ile Glu Thr Thr Gly Val
     170                 175                 180

 cat ttt cag act atg tat gag cac ttg gga gaa ctg cta aca gtt ttg      687
 His Phe Gln Thr Met Tyr Glu His Leu Gly Glu Leu Leu Thr Val Leu
 185                 190                 195                 200

 ctc acc ctg gat gaa att att gat aat cat atc aca ctg aaa gac cac      735
 Leu Thr Leu Asp Glu Ile Ile Asp Asn His Ile Thr Leu Lys Asp His
                 205                 210                 215

 tgg act atg tac aaa agg tta ctg aaa tct gtc cat cac aat cct tca      783
 Trp Thr Met Tyr Lys Arg Leu Leu Lys Ser Val His His Asn Pro Ser
             220                 225                 230

 aaa ttt gga att cag gaa gaa aaa tta aag cca ttt gaa aag ttc ttg      831
 Lys Phe Gly Ile Gln Glu Glu Lys Leu Lys Pro Phe Glu Lys Phe Leu
         235                 240                 245

 ctg aag cta gaa ggg caa tta ctg gat gga atg ata ttc cag gcc tgt      879
 Leu Lys Leu Glu Gly Gln Leu Leu Asp Gly Met Ile Phe Gln Ala Cys
     250                 255                 260

 ata gaa caa caa ttt gat tct ctc aat gga gga gta tct gtg tca aaa      927
 Ile Glu Gln Gln Phe Asp Ser Leu Asn Gly Gly Val Ser Val Ser Lys
 265                 270                 275                 280

 aat agt act ttt gct gag gaa ttt gca cat agt att cgg tca att ttt      975
 Asn Ser Thr Phe Ala Glu Glu Phe Ala His Ser Ile Arg Ser Ile Phe
                 285                 290                 295

 gca aat gta gaa gcc aaa ctt gga gaa cct tct gaa att gac cag aga     1023
 Ala Asn Val Glu Ala Lys Leu Gly Glu Pro Ser Glu Ile Asp Gln Arg
             300                 305                 310

 gac aag tat gtt gga att tgt gga ctc ttt gta ttg cac ttt cag att     1071
 Asp Lys Tyr Val Gly Ile Cys Gly Leu Phe Val Leu His Phe Gln Ile
         315                 320                 325

 ttt cga act att gat aaa aag ttt tat aag tct tta ttg gac att tgt     1119
 Phe Arg Thr Ile Asp Lys Lys Phe Tyr Lys Ser Leu Leu Asp Ile Cys
     330                 335                 340

 aag aag gta cca gcc atc act cta act gct aat att att tgg ttt cct     1167
 Lys Lys Val Pro Ala Ile Thr Leu Thr Ala Asn Ile Ile Trp Phe Pro
 345                 350                 355                 360

 gat aat ttt ctg atc cag aaa ata cca gca gct gcc aaa ctg cta gac     1215
 Asp Asn Phe Leu Ile Gln Lys Ile Pro Ala Ala Ala Lys Leu Leu Asp
                 365                 370                 375

 aga aaa agt ctt caa gcc att aaa ata cac agg gat act ttt cta caa     1263
 Arg Lys Ser Leu Gln Ala Ile Lys Ile His Arg Asp Thr Phe Leu Gln
             380                 385                 390

 cag aaa gct caa tca ctt acc aaa gat gta cag tct tac tac gtc ttt     1311
 Gln Lys Ala Gln Ser Leu Thr Lys Asp Val Gln Ser Tyr Tyr Val Phe
         395                 400                 405

 gtg agc tca tgg atg atg aaa atg gaa tct att ttg tct aaa gag cag     1359
 Val Ser Ser Trp Met Met Lys Met Glu Ser Ile Leu Ser Lys Glu Gln
     410                 415                 420

 aga atg gat aaa ttt gct gaa gat ctc acc aat aga tgt aat gtt ttt     1407
 Arg Met Asp Lys Phe Ala Glu Asp Leu Thr Asn Arg Cys Asn Val Phe
 425                 430                 435                 440

 ata cag ggc ttc ttg tat gca tat agt att agt acc att att aaa acc     1455
 Ile Gln Gly Phe Leu Tyr Ala Tyr Ser Ile Ser Thr Ile Ile Lys Thr
                 445                 450                 455

 aca atg aat ctc tac atg tcc atg caa aag cca atg acc aaa acc tca     1503
 Thr Met Asn Leu Tyr Met Ser Met Gln Lys Pro Met Thr Lys Thr Ser
             460                 465                 470

 gtt aag gca ttg tgc agg ctt gtt gaa ctt ctc aag gca ata gag cat     1551
 Val Lys Ala Leu Cys Arg Leu Val Glu Leu Leu Lys Ala Ile Glu His
         475                 480                 485

 atg ttc tac agg aga agc atg gtt gtg gct gat tca gtt tca cat ata     1599
 Met Phe Tyr Arg Arg Ser Met Val Val Ala Asp Ser Val Ser His Ile
     490                 495                 500

 aca cag cac ctt caa cat cag gct ctt cat tct att tct gtg gcc aag     1647
 Thr Gln His Leu Gln His Gln Ala Leu His Ser Ile Ser Val Ala Lys
 505                 510                 515                 520

 aaa aga gtg att tct gac aaa aaa tac agc gaa cag cgt ctt gat gtg     1695
 Lys Arg Val Ile Ser Asp Lys Lys Tyr Ser Glu Gln Arg Leu Asp Val
                 525                 530                 535

 ctc tct gct cta gtt ttg gct gaa aac act cta aat gga cca agc aca     1743
 Leu Ser Ala Leu Val Leu Ala Glu Asn Thr Leu Asn Gly Pro Ser Thr
             540                 545                 550

 aag caa cgg cga ctt att gtt tct ttg gca cta agt gtt ggc aca caa     1791
 Lys Gln Arg Arg Leu Ile Val Ser Leu Ala Leu Ser Val Gly Thr Gln
         555                 560                 565

 atg aaa aca ttt aaa gat gaa gaa ctc ttt cca ctt caa gta gtc atg     1839
 Met Lys Thr Phe Lys Asp Glu Glu Leu Phe Pro Leu Gln Val Val Met
     570                 575                 580

 aaa aaa ctg gat ctt att agt gaa ctt aga gaa cga gtc caa aca caa     1887
 Lys Lys Leu Asp Leu Ile Ser Glu Leu Arg Glu Arg Val Gln Thr Gln
 585                 590                 595                 600

 tgt gac tgt tgt ttt tta tac tgg cat cga gct gtc ttc cca att tat     1935
 Cys Asp Cys Cys Phe Leu Tyr Trp His Arg Ala Val Phe Pro Ile Tyr
                 605                 610                 615

 tta gat gat gta tat gaa aat gct gtt gat gca gcc aga tta cat tac     1983
 Leu Asp Asp Val Tyr Glu Asn Ala Val Asp Ala Ala Arg Leu His Tyr
             620                 625                 630

 atg ttc agt gct ttg cgc gac tgt gta cct gct atg atg cat gca agg     2031
 Met Phe Ser Ala Leu Arg Asp Cys Val Pro Ala Met Met His Ala Arg
         635                 640                 645

 cat tta gag tcc tat gag ata ctt ctg gat tgc tat gac aag gaa att     2079
 His Leu Glu Ser Tyr Glu Ile Leu Leu Asp Cys Tyr Asp Lys Glu Ile
     650                 655                 660

 atg gaa att tta aat gag cat ttg ctg gac aaa tta tgc aaa gaa ata     2127
 Met Glu Ile Leu Asn Glu His Leu Leu Asp Lys Leu Cys Lys Glu Ile
 665                 670                 675                 680

 gag aaa gat ctg cga ctt tct gtg cat act cat tta aag ctg gat gac     2175
 Glu Lys Asp Leu Arg Leu Ser Val His Thr His Leu Lys Leu Asp Asp
                 685                 690                 695

 cga aac cct ttc aaa gtt ggc atg aaa gac ctg gct ctt ttt ttc tct     2223
 Arg Asn Pro Phe Lys Val Gly Met Lys Asp Leu Ala Leu Phe Phe Ser
             700                 705                 710

 ctg aat cca att cgg ttt ttc aat cgt ttc att gac att cgg gct tac     2271
 Leu Asn Pro Ile Arg Phe Phe Asn Arg Phe Ile Asp Ile Arg Ala Tyr
         715                 720                 725

 gta act cac tac cta gac aag act ttc tac aat cta aca act gta gcc     2319
 Val Thr His Tyr Leu Asp Lys Thr Phe Tyr Asn Leu Thr Thr Val Ala
     730                 735                 740

 ctt cat gac tgg gcc act tat agt gag atg aga aac tta gct act cag     2367
 Leu His Asp Trp Ala Thr Tyr Ser Glu Met Arg Asn Leu Ala Thr Gln
 745                 750                 755                 760

 cgt tat gga ctg gtt atg aca gag gca cat ctt ccc agt cag act ttg     2415
 Arg Tyr Gly Leu Val Met Thr Glu Ala His Leu Pro Ser Gln Thr Leu
                 765                 770                 775

 gaa cag ggc ctt gat gtt tta gaa att atg aga aac att cat ata ttt     2463
 Glu Gln Gly Leu Asp Val Leu Glu Ile Met Arg Asn Ile His Ile Phe
             780                 785                 790

 gtg tcc cga tac ctc tat aat ctc aac aat cag att ttt att gaa cga     2511
 Val Ser Arg Tyr Leu Tyr Asn Leu Asn Asn Gln Ile Phe Ile Glu Arg
         795                 800                 805

 aca agc aat aac aag cat ttg aat act att aat att cgg cat att gct     2559
 Thr Ser Asn Asn Lys His Leu Asn Thr Ile Asn Ile Arg His Ile Ala
     810                 815                 820

 aat tca att cga aca cat ggc acg gga att atg aat aca act gtt aat     2607
 Asn Ser Ile Arg Thr His Gly Thr Gly Ile Met Asn Thr Thr Val Asn
 825                 830                 835                 840

 ttc acc tac cag ttt ttg aaa aag aag ttc tat ata ttt agc caa ttt     2655
 Phe Thr Tyr Gln Phe Leu Lys Lys Lys Phe Tyr Ile Phe Ser Gln Phe
                 845                 850                 855

 atg tat gat gaa cac atc aaa tcc aga ttg att aaa gat att cga ttt     2703
 Met Tyr Asp Glu His Ile Lys Ser Arg Leu Ile Lys Asp Ile Arg Phe
             860                 865                 870

 ttc agg gaa att aag gac caa aat gat cat aag tat cct ttt gat aga     2751
 Phe Arg Glu Ile Lys Asp Gln Asn Asp His Lys Tyr Pro Phe Asp Arg
         875                 880                 885

 gca gaa aaa ttc aat cga ggc atc aga aaa ctt gga ata aca cct gag     2799
 Ala Glu Lys Phe Asn Arg Gly Ile Arg Lys Leu Gly Ile Thr Pro Glu
     890                 895                 900

 gga cag agc tac ctt gat caa ttc agg caa ctc atc agc cag att ggt     2847
 Gly Gln Ser Tyr Leu Asp Gln Phe Arg Gln Leu Ile Ser Gln Ile Gly
 905                 910                 915                 920

 aat gct atg ggc tat gta cga atg ata aga tct ggt ggt ctt cat tgt     2895
 Asn Ala Met Gly Tyr Val Arg Met Ile Arg Ser Gly Gly Leu His Cys
                 925                 930                 935

 agc agc aat gcc att aga ttt gtt cct gat ctt gaa gat att gta aat     2943
 Ser Ser Asn Ala Ile Arg Phe Val Pro Asp Leu Glu Asp Ile Val Asn
             940                 945                 950

 ttt gaa gaa cta gta aaa gaa gaa ggt ctt gca gaa gaa aca tta aaa     2991
 Phe Glu Glu Leu Val Lys Glu Glu Gly Leu Ala Glu Glu Thr Leu Lys
         955                 960                 965

 gca gca agg cat ttg gat tca gtc ctc agt gat cac aca cga aat tct     3039
 Ala Ala Arg His Leu Asp Ser Val Leu Ser Asp His Thr Arg Asn Ser
     970                 975                 980

 gcc gaa ggc aca gaa tat ttc aaa atg ctt gta gac gtt ttt gct cca     3087
 Ala Glu Gly Thr Glu Tyr Phe Lys Met Leu Val Asp Val Phe Ala Pro
 985                 990                 995                1000

 gaa ttt cga agg cca aag aat ata cat ctc cga aat ttc tat ata att     3135
 Glu Phe Arg Arg Pro Lys Asn Ile His Leu Arg Asn Phe Tyr Ile Ile
                1005                1010                1015

 gtt ccc cct ctg acc ctc aac ttt gta gag cat tcc att agt tgc aag     3183
 Val Pro Pro Leu Thr Leu Asn Phe Val Glu His Ser Ile Ser Cys Lys
            1020                1025                1030

 gaa aaa tta aat aaa aaa aat aaa att gga gct gcc ttt act gat gat     3231
 Glu Lys Leu Asn Lys Lys Asn Lys Ile Gly Ala Ala Phe Thr Asp Asp
        1035                1040                1045

 ggc ttt gcc atg ggt gtg gct tac att cta aag ctt ttg gat cag tat     3279
 Gly Phe Ala Met Gly Val Ala Tyr Ile Leu Lys Leu Leu Asp Gln Tyr
    1050                1055                1060

 cgg gag ttt gat tca ctt cac tgg ttc cag tct gtt aga gag aaa tac     3327
 Arg Glu Phe Asp Ser Leu His Trp Phe Gln Ser Val Arg Glu Lys Tyr
1065                1070                1075                1080

 ctg aag gag ata aga gca gtt gct aag caa cag aat gta cag tca gcc     3375
 Leu Lys Glu Ile Arg Ala Val Ala Lys Gln Gln Asn Val Gln Ser Ala
                1085                1090                1095

 agt caa gat gaa aaa ctc tta caa acc atg aat ctc act cag aag cga     3423
 Ser Gln Asp Glu Lys Leu Leu Gln Thr Met Asn Leu Thr Gln Lys Arg
            1100                1105                1110

 ctg gat gtc tat cta cag gaa ttt gaa ttg ctg tat ttc tca ctg agc     3471
 Leu Asp Val Tyr Leu Gln Glu Phe Glu Leu Leu Tyr Phe Ser Leu Ser
        1115                1120                1125

 agt gca aga att ttc ttc aga gca gac aag act gcg gct gaa gaa aac     3519
 Ser Ala Arg Ile Phe Phe Arg Ala Asp Lys Thr Ala Ala Glu Glu Asn
    1130                1135                1140

 caa gaa aag aaa gag aag gaa gaa gaa act aaa aca agc aat gga gac     3567
 Gln Glu Lys Lys Glu Lys Glu Glu Glu Thr Lys Thr Ser Asn Gly Asp
1145                1150                1155                1160

 ctg tct gac agc act gtg tct gct gat cct gtt gtg aaa tga tacggat     3616
 Leu Ser Asp Ser Thr Val Ser Ala Asp Pro Val Val Lys 
                1165                1170

 ggtattcact gcacatatga tgaaatcatc agaattgtta aaacttttgc cagtggaatg   3676

 gataaactat tgatgaattg tttcctgggt cacatctctg gaaaatagat gttacagttc   3736

 ttaaaggcag tgctttaaag tgaagttcat tctgtttcca aaggctctac tttcaaaggt   3796

 taagaatgag attttaaaat tggatttttg cctggacttg agggtacaag atgtttctat   3856

 ttgaagtgaa gttataaaag ggcaaatcca gattcataaa ctatcacctc ggatttcttg   3916

 taatctacat gtttgtaatt tgtatttgca tagatctttg atctatagtt atttcaagtc   3976

 atgggaaatt caatgcatat agtatataca gccagtaaat acatgcttaa caaaaggaat   4036

 gagcctgaag ttcataaaga atacatatca atattcttat aaaaggaata tatgaagatg   4096

 gctttgatac tagaggtgag gcacaagtgt tttatgtact ctcagtgtac agtataactg   4156

 atgatccttc tttcattgtt aatttcatgt gactcacaag agctgctgat gtctttgatg   4216

 agacatttta taactagttt acattgcttt gagaacattt aacctccaac agctgcttta   4276

 aatttaagat ttacttaata ctcagaaaat tcagataaag ccatagagtc ctgtttgaag   4336

 cttcacttct attttggttg aaggcatgat gtatgatgtc agaaaaaaaa ttgaatgaat   4396

 tatttctaca tccaaactca ggtttcttct acattagatt gaattgaaat tttggtgatg   4456

 gtttgggtag actttttttt tatatcaagt ataatttaaa acatcagatt aaataattac   4516

 actgttcagg cttttaaaaa aataccactg tgagaataaa gcgctagtaa gatacatcac   4576

 ttactgattt taaaaataca gaaagatttt gagtaaattt tgtgcccagc aagctgttag   4636

 ttttattttt gtaaaggtat gtaagttatt aaatggttaa tcatggcctt ttaaaaataa   4696

 aataaagtga tacctttaca atgaagacaa aagtttaaaa ctttctaata caaacaccat   4756

 tttgggaaat gcttgatttt tttctattgc atttgtctgc taaacatttc tttggataaa   4816

 tcctgcaaat acttctaaca ttattctttg attccagctt ttagaatggg tgtacaatgc   4876

 cctgtttgta cttactggtt agggtcaggg taacttgcca gcccaagata aatactttaa   4936

 tcgttaaaag tcagaagaga cagaatatgt aggaaatgtt ttttgtttat tatgtaaaca   4996

 tggcttacag aattatgaac agtggataga ttaaaggcat ttaatatttg taattcataa   5056

 taactgtaga aatggcccta aagcatgctg cataattaat aatttatatt ttcattatta   5116

 taagtgttta tattaatgat cttgcatttg attatatcaa attcgtcatt tcatagcaac   5176

 agtattgttt tctctgtttt tcttctctaa cttctctgaa atcatctcct attaagggat   5236

 agaaattgtt actagaagag aatcacatgt tctgtgttca ttatccctac acatgtaaat   5296

 taattatttt atcaatacta gatagagttc acatgctgac tccctggata cctacagttg   5356

 agaagaaaat gacagacaat tatttttcct ttaggtcaaa ataatgtcac tgctatctgg   5416

 ataaattata agttcatata tttgaaataa gatcctggaa acgaatttaa atggtgtcaa   5476

 actgcagagc aacagggctt cagtatattc acatctaata ggttaatatg tacatttgga   5536

 tgatgatttt tcttgataac attaacatta attttatttt ttcagacata ctgtaattta   5596

 aaaattaatg tgagcgtttg ttttaagttc acagaaaact taataattca aattctcagg   5656

 aattaaggac tcaccataac attgtcagtt ctaatgaaat tttgtaaaag atggcaagtt   5716

 tgttacctca cttgagtggg gttttccttt tcccccaatt ctaagagaat ataatgtgta   5776

 tactaaaaca ttaataaaca taattttgaa aaaaaaaaaa                         5816




      <210> 416
      <211> 1039
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (252)..(746)

      <400> 416
 ggccccaccg cagctacctc agcagtcccg ccccgcccgc gtccttcccc gccgagccgg     60

 ccgctccctt ccccgcgcag ccccgcacgg cccgggccca cgtacaatga ctcttcttgc    120

 ttttcaccta agttgaataa gcaccctgtg cactttaatc tcctgtcggt accattgggc    180

 caactaaaga caaggttttg aaatctcagc tataaaagac atccagccaa actctcagtc    240

 ttgccttaac a atg ttc cag agg ctg aat aaa atg ttt gtg ggt gaa gtc     290
              Met Phe Gln Arg Leu Asn Lys Met Phe Val Gly Glu Val
                1               5                  10

 agt tct tcc tcc aac caa gaa cca gaa ttc aat gag aaa gaa gat gat      338
 Ser Ser Ser Ser Asn Gln Glu Pro Glu Phe Asn Glu Lys Glu Asp Asp
      15                  20                  25

 gaa tgg att ctt gtt gac ttc ata gat act tgc act ggt ttc tca gca      386
 Glu Trp Ile Leu Val Asp Phe Ile Asp Thr Cys Thr Gly Phe Ser Ala
  30                  35                  40                  45

 gaa gaa gaa gaa gaa gag gag gac atc agt gaa gag tca cct act gag      434
 Glu Glu Glu Glu Glu Glu Glu Asp Ile Ser Glu Glu Ser Pro Thr Glu
                  50                  55                  60

 cac cct tca gtc ttt tcc tgt tta ccg gca tct ctt gag tgc ttg gct      482
 His Pro Ser Val Phe Ser Cys Leu Pro Ala Ser Leu Glu Cys Leu Ala
              65                  70                  75

 gat aca agt gat tcc tgc ttt ctc cag ttt gag tca tgt cca atg gag      530
 Asp Thr Ser Asp Ser Cys Phe Leu Gln Phe Glu Ser Cys Pro Met Glu
          80                  85                  90

 gag agc tgg ttt atc acc cca ccc cca tgt ttt act gca ggt gga tta      578
 Glu Ser Trp Phe Ile Thr Pro Pro Pro Cys Phe Thr Ala Gly Gly Leu
      95                 100                 105

 acc act atc aag gtg gaa aca agt cct atg gaa aac ctt ctc att gaa      626
 Thr Thr Ile Lys Val Glu Thr Ser Pro Met Glu Asn Leu Leu Ile Glu
 110                 115                 120                 125

 cat ccc agc atg tct gtc tat gct gtg cat aac tcc tgc cct ggt ctc      674
 His Pro Ser Met Ser Val Tyr Ala Val His Asn Ser Cys Pro Gly Leu
                 130                 135                 140

 agt gag gcc acc cgt ggg act gat gaa tta cat agc cca agt agt ccc      722
 Ser Glu Ala Thr Arg Gly Thr Asp Glu Leu His Ser Pro Ser Ser Pro
             145                 150                 155

 agg gcc agg aaa agc tgc tta taa gactcacggg cacagaagtg gaagctcaaa     776
 Arg Ala Arg Lys Ser Cys Leu 
         160

 atgaaatggg gcagcatatt cattgttatg ttgcagctct tgctgctcat acaacttttc    836

 tggaacaacc caagagcttt cgcccttccc agtggataaa agaacacagt gaaagacagc    896

 ctcttaacag aaatagcctt cgtcgccaaa atcttaccag ggattgccac cctcggcaag    956

 tcaagcacaa tggctgggtt gttcatcagc cctgcccgcg tcagtacaat tactaatagt   1016

 ttcaagttta aaaaaaaaaa aaa                                           1039




      <210> 417
      <211> 2560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (320)..(2545)

      <400> 417
 tgacctgcgc cctctgtctg gcactcccta gtgagatgaa cccggtacct cagatggaaa     60

 tgcagaaatc acccgtcttc tgcgtcgctc acgctgggag ctgtagacca gagctgttcc    120

 tattcggcca tcttggctcc tccctcgctc ttcttggatc cctcgtggaa actacataga    180

 atctaatcgt gatgactgca cggtgtcttt gatctatgct gtgcacctta agaagtcagg    240

 ctatgtcttc tttgagtacc agtatgtcga caacaacatc ttctttgagt tctttattca    300

 aaatgatcag tgccaggag atg gac acc acc act gac aag tgg gta aaa ctt     352
                      Met Asp Thr Thr Thr Asp Lys Trp Val Lys Leu
                        1               5                  10

 aca gac aat gga gaa tgg ggc tct cat tct gta atg ctg aaa tca ggc      400
 Thr Asp Asn Gly Glu Trp Gly Ser His Ser Val Met Leu Lys Ser Gly
              15                  20                  25

 aca aac ata ctc tac tgg aga act aca ggc atc ctt atg ggt tct aag      448
 Thr Asn Ile Leu Tyr Trp Arg Thr Thr Gly Ile Leu Met Gly Ser Lys
          30                  35                  40

 gcg gtc aag cct gtg ctg gta aaa aat atc aca att gaa ggg gtg gcg      496
 Ala Val Lys Pro Val Leu Val Lys Asn Ile Thr Ile Glu Gly Val Ala
      45                  50                  55

 tac aca tca gaa tgt ttt cct tgc aag cca ggc aca ttc agc aac aaa      544
 Tyr Thr Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Phe Ser Asn Lys
  60                  65                  70                  75

 cca ggt tca ttc aac tgc cag agt tgc aaa ata att gac cca ttt ctg      592
 Pro Gly Ser Phe Asn Cys Gln Ser Cys Lys Ile Ile Asp Pro Phe Leu
                  80                  85                  90

 aaa cgc ttt ttt tat gtt gca gag gaa gga tcc agt gag tgt aca gag      640
 Lys Arg Phe Phe Tyr Val Ala Glu Glu Gly Ser Ser Glu Cys Thr Glu
              95                 100                 105

 cgc cct ccc tgt acc aca aaa gac tat ttc cag atc cat act cca tgt      688
 Arg Pro Pro Cys Thr Thr Lys Asp Tyr Phe Gln Ile His Thr Pro Cys
         110                 115                 120

 gat gaa gaa gga aag aca cag ata atg tac aag tgg ata gag ccc aaa      736
 Asp Glu Glu Gly Lys Thr Gln Ile Met Tyr Lys Trp Ile Glu Pro Lys
     125                 130                 135

 atc tgc cgg gag gat ctc aca gat gct att aga ttg ccc cct tct gga      784
 Ile Cys Arg Glu Asp Leu Thr Asp Ala Ile Arg Leu Pro Pro Ser Gly
 140                 145                 150                 155

 gag aag aag gat tgt ccg cct tgc aac cct gga ttt tat aac aat gga      832
 Glu Lys Lys Asp Cys Pro Pro Cys Asn Pro Gly Phe Tyr Asn Asn Gly
                 160                 165                 170

 tca tct tct tgc cat ccc tgt cct cct gga aca ttt tca gat gga acc      880
 Ser Ser Ser Cys His Pro Cys Pro Pro Gly Thr Phe Ser Asp Gly Thr
             175                 180                 185

 aaa gaa tgt aga cca tgt cca gca gga acg gag cct gca ctt ggc ttt      928
 Lys Glu Cys Arg Pro Cys Pro Ala Gly Thr Glu Pro Ala Leu Gly Phe
         190                 195                 200

 gaa tat aaa tgg tgg aat gtc ctt cct ggc aac atg aaa act tcc tgc      976
 Glu Tyr Lys Trp Trp Asn Val Leu Pro Gly Asn Met Lys Thr Ser Cys
     205                 210                 215

 ttc aat gtt ggg aat tca aag tgc gat gga atg aat ggt tgg gag gtg     1024
 Phe Asn Val Gly Asn Ser Lys Cys Asp Gly Met Asn Gly Trp Glu Val
 220                 225                 230                 235

 gct gga gat cat atc cag agt ggg gct gga ggt tct gac aat gat tac     1072
 Ala Gly Asp His Ile Gln Ser Gly Ala Gly Gly Ser Asp Asn Asp Tyr
                 240                 245                 250

 ctg atc tta aac ttg cat atc cca gga ttt aaa cca cca aca tct atg     1120
 Leu Ile Leu Asn Leu His Ile Pro Gly Phe Lys Pro Pro Thr Ser Met
             255                 260                 265

 act gga gcc acg ggt tct gaa cta gga aga ata aca ttt gtc ttt gag     1168
 Thr Gly Ala Thr Gly Ser Glu Leu Gly Arg Ile Thr Phe Val Phe Glu
         270                 275                 280

 acc ctc tgt tca gct gac tgt gtt ttg tac ttc atg gtg gat att aat     1216
 Thr Leu Cys Ser Ala Asp Cys Val Leu Tyr Phe Met Val Asp Ile Asn
     285                 290                 295

 aga aaa agt aca aat gtg gta gaa tcg tgg ggt gga acc aaa gaa aaa     1264
 Arg Lys Ser Thr Asn Val Val Glu Ser Trp Gly Gly Thr Lys Glu Lys
 300                 305                 310                 315

 caa gct tac acc cat atc atc ttc aag aat gca act ttt aca ttt aca     1312
 Gln Ala Tyr Thr His Ile Ile Phe Lys Asn Ala Thr Phe Thr Phe Thr
                 320                 325                 330

 tgg gca ttc cag aga act aat cag ggt caa gat aat aga cgg ttc atc     1360
 Trp Ala Phe Gln Arg Thr Asn Gln Gly Gln Asp Asn Arg Arg Phe Ile
             335                 340                 345

 aat gac atg gtg aag att tat tct atc aca gcc act aat gca gtt gat     1408
 Asn Asp Met Val Lys Ile Tyr Ser Ile Thr Ala Thr Asn Ala Val Asp
         350                 355                 360

 ggg gtg gcg tcc tca tgc cgt gcc tgt gcc ctc ggt tct gaa cag tcg     1456
 Gly Val Ala Ser Ser Cys Arg Ala Cys Ala Leu Gly Ser Glu Gln Ser
     365                 370                 375

 ggt tca tcg tgt gtc ccc tgc cct cca ggc cac tac att gag aaa gaa     1504
 Gly Ser Ser Cys Val Pro Cys Pro Pro Gly His Tyr Ile Glu Lys Glu
 380                 385                 390                 395

 acc aac cag tgc aag gaa tgt cca cct gac acc tac ctg tcc ata cat     1552
 Thr Asn Gln Cys Lys Glu Cys Pro Pro Asp Thr Tyr Leu Ser Ile His
                 400                 405                 410

 cag gtc tat ggc aaa gag gct tgt att cca tgc ggg cct ggg agt aaa     1600
 Gln Val Tyr Gly Lys Glu Ala Cys Ile Pro Cys Gly Pro Gly Ser Lys
             415                 420                 425

 aac aat cag ggg aag aag atg gct ctc tgt acc aac aat ata aca gac     1648
 Asn Asn Gln Gly Lys Lys Met Ala Leu Cys Thr Asn Asn Ile Thr Asp
         430                 435                 440

 ttt aca gta aaa gaa ata gtg gca ggg tca gat gat tac aca aat ttg     1696
 Phe Thr Val Lys Glu Ile Val Ala Gly Ser Asp Asp Tyr Thr Asn Leu
     445                 450                 455

 gta ggg gca ttt gta tgc cag tca aca att att cct tct gaa agt aag     1744
 Val Gly Ala Phe Val Cys Gln Ser Thr Ile Ile Pro Ser Glu Ser Lys
 460                 465                 470                 475

 ggt ttc cga gca gcc tta tca tca caa tcc atc att ctg gca gat aca     1792
 Gly Phe Arg Ala Ala Leu Ser Ser Gln Ser Ile Ile Leu Ala Asp Thr
                 480                 485                 490

 ttc ata gga gtc aca gtt gaa acc aca ttg aaa aat att aat ata aaa     1840
 Phe Ile Gly Val Thr Val Glu Thr Thr Leu Lys Asn Ile Asn Ile Lys
             495                 500                 505

 gaa gat atg ttc cca gtt cca aca agc caa ata cca gat gtg cat ttc     1888
 Glu Asp Met Phe Pro Val Pro Thr Ser Gln Ile Pro Asp Val His Phe
         510                 515                 520

 ttt tat aag tct tct aca gca aca aca tct tgt att aat ggc cga tca     1936
 Phe Tyr Lys Ser Ser Thr Ala Thr Thr Ser Cys Ile Asn Gly Arg Ser
     525                 530                 535

 act gct gtg aaa atg agg tgt aat cct act aaa tct gga gca gga gtg     1984
 Thr Ala Val Lys Met Arg Cys Asn Pro Thr Lys Ser Gly Ala Gly Val
 540                 545                 550                 555

 att tca gtc ccc atc aag tgc cca gca ggt acc tgt gat ggg tgt acg     2032
 Ile Ser Val Pro Ile Lys Cys Pro Ala Gly Thr Cys Asp Gly Cys Thr
                 560                 565                 570

 ttc tat ttc ctg tgg gag agt gct gaa gct tgc cct ctg tgt acg gag     2080
 Phe Tyr Phe Leu Trp Glu Ser Ala Glu Ala Cys Pro Leu Cys Thr Glu
             575                 580                 585

 cat gac ttc cat gag att gag gga gcc tgc aag aga gga ttt cag gaa     2128
 His Asp Phe His Glu Ile Glu Gly Ala Cys Lys Arg Gly Phe Gln Glu
         590                 595                 600

 acc ttg tat gtg tgg aat gaa cct aaa tgg tgc att aaa gga att tct     2176
 Thr Leu Tyr Val Trp Asn Glu Pro Lys Trp Cys Ile Lys Gly Ile Ser
     605                 610                 615

 ttg cct gag aaa aag ttg gca acc tgt gaa acg gtt gac ttt tgg ctg     2224
 Leu Pro Glu Lys Lys Leu Ala Thr Cys Glu Thr Val Asp Phe Trp Leu
 620                 625                 630                 635

 aag gtg gga gcc ggt gtg gga gct ttt act gcc gtt ttg ctg gtg gct     2272
 Lys Val Gly Ala Gly Val Gly Ala Phe Thr Ala Val Leu Leu Val Ala
                 640                 645                 650

 ctg acc tgc tac ttc tgg aaa aag aat caa aaa ctg gaa tac aaa tat     2320
 Leu Thr Cys Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr
             655                 660                 665

 tcc aag tta gta atg acg act aac tca aaa gag tgt gaa ctc ccg gct     2368
 Ser Lys Leu Val Met Thr Thr Asn Ser Lys Glu Cys Glu Leu Pro Ala
         670                 675                 680

 gca gac agt tgt gct atc atg gaa gga gaa gat aat gaa gag gaa gtt     2416
 Ala Asp Ser Cys Ala Ile Met Glu Gly Glu Asp Asn Glu Glu Glu Val
     685                 690                 695

 gta tat ttc aat aaa cag tca cta cta gga aaa ctc aaa tct ttg gca     2464
 Val Tyr Phe Asn Lys Gln Ser Leu Leu Gly Lys Leu Lys Ser Leu Ala
 700                 705                 710                 715

 acc aag gaa aaa gaa gac cat ttt gaa tct gtt caa ctg aaa acc tcc     2512
 Thr Lys Glu Lys Glu Asp His Phe Glu Ser Val Gln Leu Lys Thr Ser
                 720                 725                 730

 aaa tcc caa ata tat gaa gag aca gtg ctg tag ccttgagact aatga        2560
 Lys Ser Gln Ile Tyr Glu Glu Thr Val Leu 
             735                 740





      <210> 418
      <211> 1830
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1830)

      <400> 418
  atg gtc tac ggg gct tcc aag gca atc agg cag cct cag tct tca gct      48
  Met Val Tyr Gly Ala Ser Lys Ala Ile Arg Gln Pro Gln Ser Ser Ala
    1               5                  10                  15

 gct aag ccg aga agg agt cag tca ggg agc ctt ggg cca gag ttc cag       96
 Ala Lys Pro Arg Arg Ser Gln Ser Gly Ser Leu Gly Pro Glu Phe Gln
              20                  25                  30

 ggg ctc tgg gag tgg ctg cca gtc cag ctg tat cta ata ttg aaa gat      144
 Gly Leu Trp Glu Trp Leu Pro Val Gln Leu Tyr Leu Ile Leu Lys Asp
          35                  40                  45

 aat ctc cat gga gga gcc ccc atc ccg ccc aag gtt tct cat act cag      192
 Asn Leu His Gly Gly Ala Pro Ile Pro Pro Lys Val Ser His Thr Gln
      50                  55                  60

 tct ttg ggc gac acc tgc tgg cca tgg cag gcc ctc cat gtc cgg tgt      240
 Ser Leu Gly Asp Thr Cys Trp Pro Trp Gln Ala Leu His Val Arg Cys
  65                  70                  75                  80

 gac cag gac aca gga ggt cac tct gtg acc tgt ccg tgg ctg tgt gac      288
 Asp Gln Asp Thr Gly Gly His Ser Val Thr Cys Pro Trp Leu Cys Asp
                  85                  90                  95

 cag ggc act gac atg cgg aag ggc tat ttt gct gca ata caa ggg gac      336
 Gln Gly Thr Asp Met Arg Lys Gly Tyr Phe Ala Ala Ile Gln Gly Asp
             100                 105                 110

 cag ggc aag tcc tct cca gat ggg att tta gct gca cat ttg gaa ccc      384
 Gln Gly Lys Ser Ser Pro Asp Gly Ile Leu Ala Ala His Leu Glu Pro
         115                 120                 125

 tac acc gtc cgg gtg gag gat caa agg tca atg cgt ggc aac gtg gcc      432
 Tyr Thr Val Arg Val Glu Asp Gln Arg Ser Met Arg Gly Asn Val Ala
     130                 135                 140

 gtc ttc aag tgc ctc atc ccc tct tca gtg cag gaa tat gtt agc gtt      480
 Val Phe Lys Cys Leu Ile Pro Ser Ser Val Gln Glu Tyr Val Ser Val
 145                 150                 155                 160

 gta tct tgg gag aaa gac aca gtc tcc atc atc cca ggc aga cag gtg      528
 Val Ser Trp Glu Lys Asp Thr Val Ser Ile Ile Pro Gly Arg Gln Val
                 165                 170                 175

 cct gag caa tta att gaa aaa aca aat gag acc cgg ctg tat ttg tac      576
 Pro Glu Gln Leu Ile Glu Lys Thr Asn Glu Thr Arg Leu Tyr Leu Tyr
             180                 185                 190

 ttg agc ttg gag agg ctg gtg gtg aca gag gag gga gac agg cag gca      624
 Leu Ser Leu Glu Arg Leu Val Val Thr Glu Glu Gly Asp Arg Gln Ala
         195                 200                 205

 gaa cac tcc gag tct gca ctg gac cgt tct cag agc gct gtc ctg act      672
 Glu His Ser Glu Ser Ala Leu Asp Arg Ser Gln Ser Ala Val Leu Thr
     210                 215                 220

 gcc atg tct ttg gat gct agc cct aat ctt gtg agg cag agg acc ctc      720
 Ala Met Ser Leu Asp Ala Ser Pro Asn Leu Val Arg Gln Arg Thr Leu
 225                 230                 235                 240

 gag ggt cca agc agg cga ggg gag gct ggg agc agg ggt gtt gct aaa      768
 Glu Gly Pro Ser Arg Arg Gly Glu Ala Gly Ser Arg Gly Val Ala Lys
                 245                 250                 255

 acc att gcc agc agg ctt ctg ctc cag gcg gct tca gac acg ctc aac      816
 Thr Ile Ala Ser Arg Leu Leu Leu Gln Ala Ala Ser Asp Thr Leu Asn
             260                 265                 270

 tgg gga cca aat acc gag tgt ccg agg ggg atc cgt gct gtc tgg ggg      864
 Trp Gly Pro Asn Thr Glu Cys Pro Arg Gly Ile Arg Ala Val Trp Gly
         275                 280                 285

 gcc tct gac cac tcc gga agg gcc ttt gga aag aca cag gct tat ggt      912
 Ala Ser Asp His Ser Gly Arg Ala Phe Gly Lys Thr Gln Ala Tyr Gly
     290                 295                 300

 aga gct caa gct caa cct gtc aac cca gtg atc atg gcg att aaa aac      960
 Arg Ala Gln Ala Gln Pro Val Asn Pro Val Ile Met Ala Ile Lys Asn
 305                 310                 315                 320

 tat ctg gtc aca gca aga cct gtg tcc acg ttg ggg tgg ccg tgc cag     1008
 Tyr Leu Val Thr Ala Arg Pro Val Ser Thr Leu Gly Trp Pro Cys Gln
                 325                 330                 335

 ggc ggc tac agg aac ctg acg gag acc ctg tgg tcc caa gtc agc cac     1056
 Gly Gly Tyr Arg Asn Leu Thr Glu Thr Leu Trp Ser Gln Val Ser His
             340                 345                 350

 aca gag act gct cac tgt ggc ttt gct gtg ggc aag gcc ttg gtg gcc     1104
 Thr Glu Thr Ala His Cys Gly Phe Ala Val Gly Lys Ala Leu Val Ala
         355                 360                 365

 gag gaa cag aga ctg cct ggg cag tgt agt ggg ctg ccc tgc atg gaa     1152
 Glu Glu Gln Arg Leu Pro Gly Gln Cys Ser Gly Leu Pro Cys Met Glu
     370                 375                 380

 ggg atc ttg gtg atc att cca gcc cag ctc ttt cac ctc aat ggt gaa     1200
 Gly Ile Leu Val Ile Ile Pro Ala Gln Leu Phe His Leu Asn Gly Glu
 385                 390                 395                 400

 gaa act gag gtc cag aaa ggc aag gtg act tgt cac agc tgg acg gcc     1248
 Glu Thr Glu Val Gln Lys Gly Lys Val Thr Cys His Ser Trp Thr Ala
                 405                 410                 415

 agg aag cta tct aga atc tca ctg gct tcc cat cct ctg tct cct cca     1296
 Arg Lys Leu Ser Arg Ile Ser Leu Ala Ser His Pro Leu Ser Pro Pro
             420                 425                 430

 ccc cac ttc act gaa gac aag aca tcc ccc ttc ctc cgg gag gtg cag     1344
 Pro His Phe Thr Glu Asp Lys Thr Ser Pro Phe Leu Arg Glu Val Gln
         435                 440                 445

 gtc aat ctc atc gac ttc aag aaa tgc aat gac tac ttg gtc tat gac     1392
 Val Asn Leu Ile Asp Phe Lys Lys Cys Asn Asp Tyr Leu Val Tyr Asp
     450                 455                 460

 agt tac ctt acc cca agg atg atg tgt gct ggg gac ctt cgt ggg ggc     1440
 Ser Tyr Leu Thr Pro Arg Met Met Cys Ala Gly Asp Leu Arg Gly Gly
 465                 470                 475                 480

 aga gac tcc tgc cag gga gac agc ggg ggg cct ctt gtc tgt gag cag     1488
 Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Gln
                 485                 490                 495

 aac aac cgc tgg tac ctg gca ggt gtc acc agc tgg ggc aca ggc tgt     1536
 Asn Asn Arg Trp Tyr Leu Ala Gly Val Thr Ser Trp Gly Thr Gly Cys
             500                 505                 510

 ggc cag aga aac aaa cct ggt gtg tac acc aaa gtg aca gaa gtt ctt     1584
 Gly Gln Arg Asn Lys Pro Gly Val Tyr Thr Lys Val Thr Glu Val Leu
         515                 520                 525

 ccc tgg att tac agc aag atg gag act agc cca gtg tgg gca gat gcc     1632
 Pro Trp Ile Tyr Ser Lys Met Glu Thr Ser Pro Val Trp Ala Asp Ala
     530                 535                 540

 agc ggc cca ggt ggc gcc att gct gtc ctg gga tgg atc gtg ggt ttt     1680
 Ser Gly Pro Gly Gly Ala Ile Ala Val Leu Gly Trp Ile Val Gly Phe
 545                 550                 555                 560

 ggt gga tgc agc ttc cca ggg cct gga ccg tct tcg gtg aaa agc tgc     1728
 Gly Gly Cys Ser Phe Pro Gly Pro Gly Pro Ser Ser Val Lys Ser Cys
                 565                 570                 575

 tcc cgt tgg ctt tat gag cat caa gtc ctc acc cag acc ccc tgc tgg     1776
 Ser Arg Trp Leu Tyr Glu His Gln Val Leu Thr Gln Thr Pro Cys Trp
             580                 585                 590

 tgc cgt gga tgt cac cag tcg gac tgt gct gtg gct aac cag gct gac     1824
 Cys Arg Gly Cys His Gln Ser Asp Cys Ala Val Ala Asn Gln Ala Asp
         595                 600                 605

 aac tga                                                             1830
 Asn 






      <210> 419
      <211> 1870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1476)

      <400> 419
  atg gac ggc aac gac aac gtg acc ctg ctc ttc gcc cct ctg ctg cgg      48
  Met Asp Gly Asn Asp Asn Val Thr Leu Leu Phe Ala Pro Leu Leu Arg
    1               5                  10                  15

 gac aac tac acc ctg gcg ccc aat gcc agc agc ctg ggc ccc ggc acg       96
 Asp Asn Tyr Thr Leu Ala Pro Asn Ala Ser Ser Leu Gly Pro Gly Thr
              20                  25                  30

 aac ctc gcc ctc gcc cct gcc tcc agc gcc ggc ccc ggc cct ggg ctc      144
 Asn Leu Ala Leu Ala Pro Ala Ser Ser Ala Gly Pro Gly Pro Gly Leu
          35                  40                  45

 agc ctc ggg ccg gta ccg agc ttc ggc ttc agc ccc ggc ccc act ccg      192
 Ser Leu Gly Pro Val Pro Ser Phe Gly Phe Ser Pro Gly Pro Thr Pro
      50                  55                  60

 acc ccg gag ccc acg acc agc ggc ctc gcg ggc ggc gcg gcg agc cac      240
 Thr Pro Glu Pro Thr Thr Ser Gly Leu Ala Gly Gly Ala Ala Ser His
  65                  70                  75                  80

 ggc cct tcc ccg ttc cct cgg ccc tgg gcg ccc cac gcg ctc ccg ttc      288
 Gly Pro Ser Pro Phe Pro Arg Pro Trp Ala Pro His Ala Leu Pro Phe
                  85                  90                  95

 tgg gac acg ccg ctg aac cac ggg ctg aac gtg ttc gtg ggc gcc gcc      336
 Trp Asp Thr Pro Leu Asn His Gly Leu Asn Val Phe Val Gly Ala Ala
             100                 105                 110

 ctg tgc atc acc atg ctg ggc ctg ggc tgc acg gtg gac gtg aac cac      384
 Leu Cys Ile Thr Met Leu Gly Leu Gly Cys Thr Val Asp Val Asn His
         115                 120                 125

 ttc ggg gcg cac gtc cgt cgg ccc gtg gcg gcg ctg ctg gca gct ctg      432
 Phe Gly Ala His Val Arg Arg Pro Val Ala Ala Leu Leu Ala Ala Leu
     130                 135                 140

 cca gtt cgg cct cct gcc gct gct ggc ctt cct gct ggc cct cgc ctt      480
 Pro Val Arg Pro Pro Ala Ala Ala Gly Leu Pro Ala Gly Pro Arg Leu
 145                 150                 155                 160

 caa gct gga cga ggt ggc cgc cgt ggg ctg ctc ctg tgt ggc tgc tgt      528
 Gln Ala Gly Arg Gly Gly Arg Arg Gly Leu Leu Leu Cys Gly Cys Cys
                 165                 170                 175

 ccc ggc ggc aat ctc tcc aat ctt atg tcc ctg ctg gtt gac ggc gac      576
 Pro Gly Gly Asn Leu Ser Asn Leu Met Ser Leu Leu Val Asp Gly Asp
             180                 185                 190

 atg aac ctc aga cgt gct gct ctc ttg gca ctc tcc tcg gat gta ggt      624
 Met Asn Leu Arg Arg Ala Ala Leu Leu Ala Leu Ser Ser Asp Val Gly
         195                 200                 205

 tct gcc cag act tca acc ccg gga ctt gca gtc tcc ccg ttc cac ctc      672
 Ser Ala Gln Thr Ser Thr Pro Gly Leu Ala Val Ser Pro Phe His Leu
     210                 215                 220

 tac tca aca tac aag aaa aag gtt agc tgg ctg ttt gac tca aag ctc      720
 Tyr Ser Thr Tyr Lys Lys Lys Val Ser Trp Leu Phe Asp Ser Lys Leu
 225                 230                 235                 240

 gtt ctg att tct gca cat tcc ctt ttc tgc agc atc atc atg acc atc      768
 Val Leu Ile Ser Ala His Ser Leu Phe Cys Ser Ile Ile Met Thr Ile
                 245                 250                 255

 tcc tcc acg ctt ctg gcc ctc gtc ttg atg ccc ctg tgc ctg tgg atc      816
 Ser Ser Thr Leu Leu Ala Leu Val Leu Met Pro Leu Cys Leu Trp Ile
             260                 265                 270

 tac agc tgg gct tgg atc aac acc cct atc gtg cag tta cta ccc cta      864
 Tyr Ser Trp Ala Trp Ile Asn Thr Pro Ile Val Gln Leu Leu Pro Leu
         275                 280                 285

 ggg acc gtg acc ctg act ctc tgc agc act ctc ata cct atc ggg ttg      912
 Gly Thr Val Thr Leu Thr Leu Cys Ser Thr Leu Ile Pro Ile Gly Leu
     290                 295                 300

 ggc gtc ttc att cgc tac aaa tac agc cgg gtg gct gac tac att gtg      960
 Gly Val Phe Ile Arg Tyr Lys Tyr Ser Arg Val Ala Asp Tyr Ile Val
 305                 310                 315                 320

 aag gtt tcc ctg tgg tct ctg cta gtg act ctg gtg gtc ctt ttc ata     1008
 Lys Val Ser Leu Trp Ser Leu Leu Val Thr Leu Val Val Leu Phe Ile
                 325                 330                 335

 atg acc ggc act atg tta gga cct gaa ctg ctg gca agt atc cct gca     1056
 Met Thr Gly Thr Met Leu Gly Pro Glu Leu Leu Ala Ser Ile Pro Ala
             340                 345                 350

 gct gtt tat gtg ata gca att ttt atg cct ttg gca gcg tac gct tca     1104
 Ala Val Tyr Val Ile Ala Ile Phe Met Pro Leu Ala Ala Tyr Ala Ser
         355                 360                 365

 ggt tat ggt tta gct act ctc ttc cat ctt cca ccc aac tgc aag agg     1152
 Gly Tyr Gly Leu Ala Thr Leu Phe His Leu Pro Pro Asn Cys Lys Arg
     370                 375                 380

 act gta tgt ctg gaa aca ggt agt cag aat gtg cag ctc tgt aca gcc     1200
 Thr Val Cys Leu Glu Thr Gly Ser Gln Asn Val Gln Leu Cys Thr Ala
 385                 390                 395                 400

 att cta aaa ctg gcc ttt cca ccg caa ttc ata gga agc atg tac atg     1248
 Ile Leu Lys Leu Ala Phe Pro Pro Gln Phe Ile Gly Ser Met Tyr Met
                 405                 410                 415

 ttt cct ttg ctg tat gca ctt ttc cag tct gca gaa gcg ggg att ttt     1296
 Phe Pro Leu Leu Tyr Ala Leu Phe Gln Ser Ala Glu Ala Gly Ile Phe
             420                 425                 430

 gtt tta atc tat aaa atg tat gga agt gaa atg ttg cac aag cga gat     1344
 Val Leu Ile Tyr Lys Met Tyr Gly Ser Glu Met Leu His Lys Arg Asp
         435                 440                 445

 cct cta gat gaa gat gaa gat aca gat att tct tat aaa aaa cta aaa     1392
 Pro Leu Asp Glu Asp Glu Asp Thr Asp Ile Ser Tyr Lys Lys Leu Lys
     450                 455                 460

 gaa gag gaa atg gca gac act tcc tat ggc aca gtg aaa gca gaa aat     1440
 Glu Glu Glu Met Ala Asp Thr Ser Tyr Gly Thr Val Lys Ala Glu Asn
 465                 470                 475                 480

 ata ata atg atg gaa acc gct cag act tct ctc taa atgt ggagatacac     1490
 Ile Ile Met Met Glu Thr Ala Gln Thr Ser Leu 
                 485                 490

 aggagcttct atcttgctga aatattgctt catatttata gcctgtggta gtgcacatgg   1550

 ttaacataaa agataacact ggttcacatc atacatgtaa caattctgat ctttttaagg   1610

 ttcactggtg tattaaccaa acgttgtcac aaattacaaa tcaatgctgt aatataattt   1670

 gcacctggaa tggctaacgt gaagcctgaa ttaaatgtgg tttttagttt ttaccatcac   1730

 caatttctat gactgttgca aatacagaat ctattagaaa acagggtctt ggaaatgtag   1790

 aattttggcg cactatgagg aaaaacaagc tatctttgta aagcataatt gagtttaatg   1850

 taattgttgt aaaaaaaaaa                                               1870




      <210> 420
      <211> 655
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(509)

      <400> 420
 ccgccttcgg cgcgaaggtg gctggtgcgt accgtcccga accctaggag ccgagagact     60

 cctcccctgt cgcccagatc ccacccgcag gaccccaaaa ccca atg atc ctg cag     116
                                                  Met Ile Leu Gln
                                                    1

 cag ccc ttg cag cga ggc ccc cag gga ggg gcc cag cgc ctc ccg cgg      164
 Gln Pro Leu Gln Arg Gly Pro Gln Gly Gly Ala Gln Arg Leu Pro Arg
   5                  10                  15                  20

 gcc gcc ttg ggg gtg act tgg ggc ctg gac gcc agc tcc cct ctc cga      212
 Ala Ala Leu Gly Val Thr Trp Gly Leu Asp Ala Ser Ser Pro Leu Arg
                  25                  30                  35

 gga gct gtg ccc atg agc acc aag cgg cgc ctg gag gag gag cag gag      260
 Gly Ala Val Pro Met Ser Thr Lys Arg Arg Leu Glu Glu Glu Gln Glu
              40                  45                  50

 cct ctg cgc aag cag ttt ctg tct gag gag aac atg gcc acc cac ttc      308
 Pro Leu Arg Lys Gln Phe Leu Ser Glu Glu Asn Met Ala Thr His Phe
          55                  60                  65

 tct caa ctc agc ctg cac aat gac cac ccc tac tgc agc ccc ccc atg      356
 Ser Gln Leu Ser Leu His Asn Asp His Pro Tyr Cys Ser Pro Pro Met
      70                  75                  80

 acc ttc tcc cca gcc ctg ccc cca ctc agg agc cct tgc tct gag ctg      404
 Thr Phe Ser Pro Ala Leu Pro Pro Leu Arg Ser Pro Cys Ser Glu Leu
  85                  90                  95                 100

 ctt ctc tgg cgc tat cct ggc agc ctc atc cct gag gcc ctc cgt ctg      452
 Leu Leu Trp Arg Tyr Pro Gly Ser Leu Ile Pro Glu Ala Leu Arg Leu
                 105                 110                 115

 ctg agg ctg ggg gac acc cca gtc ccc cct acc ctg caa ccc cag ctg      500
 Leu Arg Leu Gly Asp Thr Pro Val Pro Pro Thr Leu Gln Pro Gln Leu
             120                 125                 130

 ggg aca taa tggagct tctgagtgct ggtgggacag tgcccctcca acttccttct      556
 Gly Thr 


 tcccccaaaa gagagacagc gctccgcaag gcaagttcct cctctctgag agtaggattt    616

 ggccccaggg gccctcaaaa ggaatgagcc aacgggttt                           655




      <210> 421
      <211> 1016
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(969)

      <400> 421
  atg gca tcc tct ctg aag atc tgg ggc agt ccc ttg gcc ctg ctt tgc      48
  Met Ala Ser Ser Leu Lys Ile Trp Gly Ser Pro Leu Ala Leu Leu Cys
    1               5                  10                  15

 att ctt tgc agg cta ctt gta cac agc aag gac gtt tcc tgg aga gaa       96
 Ile Leu Cys Arg Leu Leu Val His Ser Lys Asp Val Ser Trp Arg Glu
              20                  25                  30

 ttc atg acc ctg cac tat tta gat cca agc caa gat ttt gaa gag tac      144
 Phe Met Thr Leu His Tyr Leu Asp Pro Ser Gln Asp Phe Glu Glu Tyr
          35                  40                  45

 aaa tgt gat gtc ctc acg aga gaa aaa gaa gct ctg aaa cgc aag agc      192
 Lys Cys Asp Val Leu Thr Arg Glu Lys Glu Ala Leu Lys Arg Lys Ser
      50                  55                  60

 tct cat atg tcc atc tat agc tta tgg cac aaa atg gag tgt ata tgc      240
 Ser His Met Ser Ile Tyr Ser Leu Trp His Lys Met Glu Cys Ile Cys
  65                  70                  75                  80

 att att gaa atg gga ata acc gat ata gat atg cct atg tat ggg ccc      288
 Ile Ile Glu Met Gly Ile Thr Asp Ile Asp Met Pro Met Tyr Gly Pro
                  85                  90                  95

 agg gtg ccc tca aag tac tcg agt gtc agt ggc aga agt act gca ata      336
 Arg Val Pro Ser Lys Tyr Ser Ser Val Ser Gly Arg Ser Thr Ala Ile
             100                 105                 110

 gct aca cag aga tct tca act aca ttg aat tcc act gtg gca agg atg      384
 Ala Thr Gln Arg Ser Ser Thr Thr Leu Asn Ser Thr Val Ala Arg Met
         115                 120                 125

 gga tgg gtg aat att aca gtg tcc cca gat caa gcc cgt acc ttg caa      432
 Gly Trp Val Asn Ile Thr Val Ser Pro Asp Gln Ala Arg Thr Leu Gln
     130                 135                 140

 gct gca ttg ttg cag caa ctg gct cag aat ttc tct ctc atc cct gaa      480
 Ala Ala Leu Leu Gln Gln Leu Ala Gln Asn Phe Ser Leu Ile Pro Glu
 145                 150                 155                 160

 gaa ttc cta caa gag gtg gac acg cag gtg gac gtg gtg act gag atg      528
 Glu Phe Leu Gln Glu Val Asp Thr Gln Val Asp Val Val Thr Glu Met
                 165                 170                 175

 aca tcc tct cta aag att tgg ggc ata ctc ttg gcc ctg ctt tgc atc      576
 Thr Ser Ser Leu Lys Ile Trp Gly Ile Leu Leu Ala Leu Leu Cys Ile
             180                 185                 190

 ctt tgc agg ctg tgt gta tac agt aac aac att tac tgg aga gaa ttc      624
 Leu Cys Arg Leu Cys Val Tyr Ser Asn Asn Ile Tyr Trp Arg Glu Phe
         195                 200                 205

 ata aaa ctt cat tac tta agt cca agt cga gaa ttc aaa gag tac aaa      672
 Ile Lys Leu His Tyr Leu Ser Pro Ser Arg Glu Phe Lys Glu Tyr Lys
     210                 215                 220

 tgt gat gtc ctc atg aga gaa aaa gag gct ctg aaa ggc aag agc ttt      720
 Cys Asp Val Leu Met Arg Glu Lys Glu Ala Leu Lys Gly Lys Ser Phe
 225                 230                 235                 240

 cat atg ttc atc tat agc tta tgg ttc aaa att cag cgt gca tgc atc      768
 His Met Phe Ile Tyr Ser Leu Trp Phe Lys Ile Gln Arg Ala Cys Ile
                 245                 250                 255

 aat gag aag ggg agc gac cga tat aga aat gca tat gta tgg gcc cca      816
 Asn Glu Lys Gly Ser Asp Arg Tyr Arg Asn Ala Tyr Val Trp Ala Pro
             260                 265                 270

 ggt gcc ctc aaa gta ctc gag tgt cac tgg gag aag tac aac aat agg      864
 Gly Ala Leu Lys Val Leu Glu Cys His Trp Glu Lys Tyr Asn Asn Arg
         275                 280                 285

 tac aca gag agc aga agc ttc agc tac att gaa ttc cat tgt ggc gta      912
 Tyr Thr Glu Ser Arg Ser Phe Ser Tyr Ile Glu Phe His Cys Gly Val
     290                 295                 300

 gat gga tat gtt gat aac ata gaa gac ctg agg att ata gaa cct atc      960
 Asp Gly Tyr Val Asp Asn Ile Glu Asp Leu Arg Ile Ile Glu Pro Ile
 305                 310                 315                 320

 agc aac tag aaagtct atgcacatcc tcagatattg gtagagtatt cagtgcttcc     1016
 Ser Asn 






      <210> 422
      <211> 2242
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (803)..(2242)

      <400> 422
 cgtcccaacc cagggagacc attcagctca cctgcatagg ccgcagcagc atttccttcc     60

 taatcaggct caccaggggg atcattaccg tctctcccaa cctggcctgg gtcagcagca    120

 gcagcaacag cagcagcagc accatcatca ccatcaccac caacaacagc agcagcagca    180

 gccacagcag cagccaggag aagcctattc agctatgcct cgggctcagc catcctctgc    240

 ttcttatcag ccagtgccag cagacccttt tgccattgtt tccagagccc agcagatggt    300

 tgagatcctc tcagacgaga accggaactt gaggcaagag ttggaaggat gctatgagaa    360

 ggtggcaaga ctgcagaagg tggagacaga aatccagcgc gtctcggagg catatgagaa    420

 cctcgtgaag tcatcctcca aaagagaggc cctagagaaa gccatgagaa acaagctaga    480

 gggcgagatt cggaggatgc atgatttcaa cagggatctg agagagcgtc tagagactgc    540

 caacaagcag cttgcagaga aggaatatga ggggtcagag gacaccagaa aaaccatctc    600

 gcagctcttt gcaaaaaata aagaaagcca gcgtgagaag gagaagctgg aagcggagct    660

 ggccactgcc cgttctacca atgaggacca aagacgacac atcgaaatcc gagatcaggc    720

 cctgagtaat gcccaggcca aggtggtaaa gctggaagaa gagctgaaaa agaagcaagt    780

 gtacgttgac aaggtggaga ag atg cag cag gcc ctt gta cag ctc cag gca     832
                          Met Gln Gln Ala Leu Val Gln Leu Gln Ala
                            1               5                  10

 gca tgt gaa aaa cgt gag cag cta gag cac cgt ctc cgg aca cga ctg      880
 Ala Cys Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Thr Arg Leu
                  15                  20                  25

 gag agg gaa ctg gaa tcc ctg aga atc cag cag cgt cag ggc aac tgt      928
 Glu Arg Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys
              30                  35                  40

 cag ccc acc aac gtt tca gaa tac aat gct gct gca ctg atg gag ctc      976
 Gln Pro Thr Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu
          45                  50                  55

 ctt cgg gag aaa gag gag agg att ctg gct ctg gaa gct gat atg aca     1024
 Leu Arg Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr
      60                  65                  70

 aag tgg gag cag aaa tat ttg gag gag aat gtg atg aga cat ttt gct     1072
 Lys Trp Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala
  75                  80                  85                  90

 ctg gat gct gct gca act gtg gct gct cag agg gac aca aca gtc atc     1120
 Leu Asp Ala Ala Ala Thr Val Ala Ala Gln Arg Asp Thr Thr Val Ile
                  95                 100                 105

 agt cac tct cct aac acc agc tat gac aca gct cta gaa gct cgc atc     1168
 Ser His Ser Pro Asn Thr Ser Tyr Asp Thr Ala Leu Glu Ala Arg Ile
             110                 115                 120

 cag aaa gag gag gaa gaa atc ttg atg gcc aat aag cgt tgc ctt gac     1216
 Gln Lys Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp
         125                 130                 135

 atg gag ggc agg att aag acc ctc cat gcc cag att att gag aag gat     1264
 Met Glu Gly Arg Ile Lys Thr Leu His Ala Gln Ile Ile Glu Lys Asp
     140                 145                 150

 gcc atg atc aaa gta ctc cag cag cgt tcc cgg aag gag ccg agc aag     1312
 Ala Met Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys
 155                 160                 165                 170

 aca gag cag ctg tcg tgc atg cgg cca gcg aag tct ctg atg tcc att     1360
 Thr Glu Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile
                 175                 180                 185

 tcc aat gct gga tca ggc ttg ctc tcc cac tca tcc acc ctg act ggc     1408
 Ser Asn Ala Gly Ser Gly Leu Leu Ser His Ser Ser Thr Leu Thr Gly
             190                 195                 200

 tcc ccc atc atg gaa gaa aag cga gac gac aag agc tgg aag ggg agc     1456
 Ser Pro Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser
         205                 210                 215

 cta ggc att ctc ctg ggt gga gac tac cgt gct gaa tat gtc cct tcc     1504
 Leu Gly Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser
     220                 225                 230

 aca ccc tcg cct gtg cca ccc tcg act ccc ctg ctc tcg gct cac tcc     1552
 Thr Pro Ser Pro Val Pro Pro Ser Thr Pro Leu Leu Ser Ala His Ser
 235                 240                 245                 250

 aag aca ggc agc cga gac tgc agt acc caa act gaa cgt ggg acg gaa     1600
 Lys Thr Gly Ser Arg Asp Cys Ser Thr Gln Thr Glu Arg Gly Thr Glu
                 255                 260                 265

 tcg aac aaa act gca gct gtt gct ccc atc tct gtt cct gct cca gtt     1648
 Ser Asn Lys Thr Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val
             270                 275                 280

 gct gct gcc gcc act gct gcc gcc atc act gcc act gct gcc acc atc     1696
 Ala Ala Ala Ala Thr Ala Ala Ala Ile Thr Ala Thr Ala Ala Thr Ile
         285                 290                 295

 acc acc acc atg gta gct gct gct cca gtt gct gtt gct gct gct gct     1744
 Thr Thr Thr Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala
     300                 305                 310

 gct cca gct gct gct gct gcc ccg tct cca gcc act gcc gct gct act     1792
 Ala Pro Ala Ala Ala Ala Ala Pro Ser Pro Ala Thr Ala Ala Ala Thr
 315                 320                 325                 330

 gct gct gct gtt tct cca gct gct gct ggt cag att cca gct gct gcc     1840
 Ala Ala Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala
                 335                 340                 345

 tct gtt gcc tca gct gct gcc gtt gct cct tct gct gct gct gct gct     1888
 Ser Val Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala
             350                 355                 360

 gct gtt cag gtt gct cca gct gct ccg gct cca gtt cca gct ccg gct     1936
 Ala Val Gln Val Ala Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala
         365                 370                 375

 ctg gtt ccg gtt cca gct cca gca gcg gct cag gct tct gct cct gct     1984
 Leu Val Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala
     380                 385                 390

 cag act cag gca cca act tca gct ccg gct gtg gct cca act cca gct     2032
 Gln Thr Gln Ala Pro Thr Ser Ala Pro Ala Val Ala Pro Thr Pro Ala
 395                 400                 405                 410

 cca act cca act cca gct gtg gct cag gct gag gtt cct gca agt cca     2080
 Pro Thr Pro Thr Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro
                 415                 420                 425

 gct acc ggt cct gga cca cat cgt ttg tct ata cca agt ttg acc tgc     2128
 Ala Thr Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Thr Cys
             430                 435                 440

 aat cca gac aaa aca gat ggg cct gtg ttc cac tcc aat act ctg gaa     2176
 Asn Pro Asp Lys Thr Asp Gly Pro Val Phe His Ser Asn Thr Leu Glu
         445                 450                 455

 aga aaa act ccc att cag atc ctg gga caa gag cct gat gca gag atg     2224
 Arg Lys Thr Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met
     460                 465                 470

 gtg gaa tat ctc atc taa                                             2242
 Val Glu Tyr Leu Ile 
 475





      <210> 423
      <211> 853
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(637)

      <400> 423
 gcacgaggtt attatgcagg caactcactt tatcccaatt tcttgatact tttccttctg     60

 gaggtcctat ttctctaaca tcttccagaa aagtcttaaa gctgccttaa ccttttttcc    120

 agtccacctc ttaaattttt tcctcctctt cctctatact aac  atg agt gtg gat     175
                                                  Met Ser Val Asp
                                                    1

 cca gct tgt ccc caa agc ttg cct tgc ttt gaa gca tcc gac tgt aaa      223
 Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala Ser Asp Cys Lys
   5                  10                  15                  20

 gaa tct tca cct atg cct gtg att tgt ggg cct gaa gaa aac tat cca      271
 Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu Glu Asn Tyr Pro
                  25                  30                  35

 tcc ttg caa atg tct tct gct gag atg cct cac acg gag act gtc tct      319
 Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr Glu Thr Val Ser
              40                  45                  50

 cct ctt ccc tcc tcc atg gat ctg ctt att cag gac agc cct gat tct      367
 Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp Ser Pro Asp Ser
          55                  60                  65

 tcc acc agt ccc aaa ggc aaa caa ccc act tct gca gag aat agt gtc      415
 Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala Glu Asn Ser Val
      70                  75                  80

 gca aaa aag gaa gac aag gtc cca gtc aag aaa cag aag acc aga act      463
 Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln Lys Thr Arg Thr
  85                  90                  95                 100

 gtg ttc tct tcc acc cag ctg tgt gta ctc aat gat aga ttt cag aga      511
 Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp Arg Phe Gln Arg
                 105                 110                 115

 cag aaa tac ctc agc ctc cag cag atg caa gaa ctc tcc aac atc ctg      559
 Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu Ser Asn Ile Leu
             120                 125                 130

 aac ctc agc tac aaa cag gta ggc ttg ttt tgt cct tgc aat aag gtg      607
 Asn Leu Ser Tyr Lys Gln Val Gly Leu Phe Cys Pro Cys Asn Lys Val
         135                 140                 145

 acc aaa aat tgg act aat ttg cat ggc taa g atctctgtgg atgcatgtag      658
 Thr Lys Asn Trp Thr Asn Leu His Gly 
     150                 155

 atgtgtgtac tatgtgtccg tacatcgcct cttgcaagta atttatgaag atgaaatgct    718

 tttgtaactt ccttcacctc tttctttcct taaatattct attatgtgaa taattatgtc    778

 ataatttaac cactttcttg cacagaccaa tattgtgaaa atctttccaa cgtttcctta    838

 ataaaaaaaa aaaaa                                                     853




      <210> 424
      <211> 603
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (350)..(553)

      <400> 424
 cagaaaaact cagcccacac cctaaaatgt aaacctttgg aaaaaggaga agtgctccgt     60

 taagcaagct acaatgcagg ggcagatcct aggaagggag cagaactgcc agggttccaa    120

 ccaaagaaag aggttaatta ataatgggca atattgggga gatgggtggg gaaaagagga    180

 aaaagctccg ctaacctaag aataccacaa ccctgaaagg agcgccttct agaacaaagg    240

 taaaatcact aggacagatc tgttagggtt ttcctttcac tcttgtagta gaatgctgat    300

 ctaacgggag ttttgaagtg tggagcaggg gggaaaaaaa agaaagaaa    atg aga     355
                                                          Met Arg
                                                            1

 att tta att ttt gaa ata acg gca att tat cca ttg cac ata cca ctg      403
 Ile Leu Ile Phe Glu Ile Thr Ala Ile Tyr Pro Leu His Ile Pro Leu
           5                  10                  15

 tat tat gca aat caa cgt ttt gga aaa ttt aga cac aga agg gaa cta      451
 Tyr Tyr Ala Asn Gln Arg Phe Gly Lys Phe Arg His Arg Arg Glu Leu
      20                  25                  30

 gac agt ttt ccc cct gga gag atg aaa agc ttt ttg gct ctt aag tct      499
 Asp Ser Phe Pro Pro Gly Glu Met Lys Ser Phe Leu Ala Leu Lys Ser
  35                  40                  45                  50

 ttg ata aaa ggc gta cat aat tct tgt gtc tac tgt aca gaa tac tgc      547
 Leu Ile Lys Gly Val His Asn Ser Cys Val Tyr Cys Thr Glu Tyr Cys
                  55                  60                  65

 cgc tag ctggatttcc caattctgag taacactctg caatccaaac agggttcaac       603
 Arg 






      <210> 425
      <211> 1562
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1389)

      <400> 425
  atg ctg cta aac atc act cga tgc cag aca acc ccc aca aca agg aat      48
  Met Leu Leu Asn Ile Thr Arg Cys Gln Thr Thr Pro Thr Thr Arg Asn
    1               5                  10                  15

 tat gtg ggc caa aat gtc att aat acc agg att gag aaa cct act cta       96
 Tyr Val Gly Gln Asn Val Ile Asn Thr Arg Ile Glu Lys Pro Thr Leu
              20                  25                  30

 gag aag aaa gtg aga aag aaa agt agc tca gag cgg tct gtg cta tgt      144
 Glu Lys Lys Val Arg Lys Lys Ser Ser Ser Glu Arg Ser Val Leu Cys
          35                  40                  45

 gag gta tgt aaa att aat cag gcc cag aga gac atg agt atg aaa ctt      192
 Glu Val Cys Lys Ile Asn Gln Ala Gln Arg Asp Met Ser Met Lys Leu
      50                  55                  60

 cag cac act cct gct ggc aag tca ctg gcg aga act gaa gtt ttg gaa      240
 Gln His Thr Pro Ala Gly Lys Ser Leu Ala Arg Thr Glu Val Leu Glu
  65                  70                  75                  80

 ggg gct gac agc agt tac gat gaa tgg tta tta ctg cag agg gcc act      288
 Gly Ala Asp Ser Ser Tyr Asp Glu Trp Leu Leu Leu Gln Arg Ala Thr
                  85                  90                  95

 cat ttc ttt gtg tct tta gat aag aaa ggt tac tgt gag gac tac aat      336
 His Phe Phe Val Ser Leu Asp Lys Lys Gly Tyr Cys Glu Asp Tyr Asn
             100                 105                 110

 gga aaa tta gtt tgc act agg ctg aag gga gag gtg gaa cgg att cgt      384
 Gly Lys Leu Val Cys Thr Arg Leu Lys Gly Glu Val Glu Arg Ile Arg
         115                 120                 125

 cta tct acg cac ctc gag gag ggg tgt gtg agg agc tac gtt cca gag      432
 Leu Ser Thr His Leu Glu Glu Gly Cys Val Arg Ser Tyr Val Pro Glu
     130                 135                 140

 aac ggt aag aaa ctc cgg cca gga aac acg gga tca cag gag aac tcg      480
 Asn Gly Lys Lys Leu Arg Pro Gly Asn Thr Gly Ser Gln Glu Asn Ser
 145                 150                 155                 160

 agg cga agg ggc act atg aac gaa gag gag cag ttt gta aac att gat      528
 Arg Arg Arg Gly Thr Met Asn Glu Glu Glu Gln Phe Val Asn Ile Asp
                 165                 170                 175

 ttg aat gat gac aac att tgc agt gtt tgt aaa ctg gga aca gac aaa      576
 Leu Asn Asp Asp Asn Ile Cys Ser Val Cys Lys Leu Gly Thr Asp Lys
             180                 185                 190

 gaa aca ctc tcc ttc tgc cac att tgt ttt gag cta aat att gag ggg      624
 Glu Thr Leu Ser Phe Cys His Ile Cys Phe Glu Leu Asn Ile Glu Gly
         195                 200                 205

 gta cca aag tct gat ctc ttg cac acc aaa tca tta agg ggc cat aaa      672
 Val Pro Lys Ser Asp Leu Leu His Thr Lys Ser Leu Arg Gly His Lys
     210                 215                 220

 gac tgc ttt gaa aaa tac cat tta att gca aac cag ggt tgt cct cga      720
 Asp Cys Phe Glu Lys Tyr His Leu Ile Ala Asn Gln Gly Cys Pro Arg
 225                 230                 235                 240

 tct aag ctt tca aaa agt act tat gaa gaa gtt aaa acc att ttg agt      768
 Ser Lys Leu Ser Lys Ser Thr Tyr Glu Glu Val Lys Thr Ile Leu Ser
                 245                 250                 255

 aag aag ata aac tgg att gtg cag tat gca caa aat aag gat ctg gat      816
 Lys Lys Ile Asn Trp Ile Val Gln Tyr Ala Gln Asn Lys Asp Leu Asp
             260                 265                 270

 tca gat tct gaa tgt tct aaa aac ccc cag cat cat ctg ttt aat ttc      864
 Ser Asp Ser Glu Cys Ser Lys Asn Pro Gln His His Leu Phe Asn Phe
         275                 280                 285

 agg cat aag cca gaa gaa aaa tta ctc cca cag ttt gac tcc caa gta      912
 Arg His Lys Pro Glu Glu Lys Leu Leu Pro Gln Phe Asp Ser Gln Val
     290                 295                 300

 cca aaa tat tct gca aaa tgg ata gat gga agt gca ggt ggc atc tct      960
 Pro Lys Tyr Ser Ala Lys Trp Ile Asp Gly Ser Ala Gly Gly Ile Ser
 305                 310                 315                 320

 aac tgt aca caa aga att ttg gag cag agg gaa aat aca gac ttt gga     1008
 Asn Cys Thr Gln Arg Ile Leu Glu Gln Arg Glu Asn Thr Asp Phe Gly
                 325                 330                 335

 ctt tct atg tta caa gat tca ggt gcc act tta tgt cgt aac agt gta     1056
 Leu Ser Met Leu Gln Asp Ser Gly Ala Thr Leu Cys Arg Asn Ser Val
             340                 345                 350

 ttg tgg cct cat agt cac aac cag gca cag aaa aaa gaa gag aca atc     1104
 Leu Trp Pro His Ser His Asn Gln Ala Gln Lys Lys Glu Glu Thr Ile
         355                 360                 365

 tct agt cca gag gct aat gtc cag acc cag cat cca cat tac agc aga     1152
 Ser Ser Pro Glu Ala Asn Val Gln Thr Gln His Pro His Tyr Ser Arg
     370                 375                 380

 gag gaa ttg aat tcg atg act ctt ggt gag gta gag caa ctg aat gca     1200
 Glu Glu Leu Asn Ser Met Thr Leu Gly Glu Val Glu Gln Leu Asn Ala
 385                 390                 395                 400

 aag ctc cta cag caa atc cag gaa gtt ttt gaa gag tta act cac caa     1248
 Lys Leu Leu Gln Gln Ile Gln Glu Val Phe Glu Glu Leu Thr His Gln
                 405                 410                 415

 gtg caa gaa aaa gat tct ttg gcc tca cag ctc cat gtc cgc cac gtt     1296
 Val Gln Glu Lys Asp Ser Leu Ala Ser Gln Leu His Val Arg His Val
             420                 425                 430

 gcc atc gaa cag ctt ctg aag aac tgt tct aag tta cca tgt ctg caa     1344
 Ala Ile Glu Gln Leu Leu Lys Asn Cys Ser Lys Leu Pro Cys Leu Gln
         435                 440                 445

 gta ggg cga aca gga atg aag tcg cac cta ccc ata aac aac tga cct     1392
 Val Gly Arg Thr Gly Met Lys Ser His Leu Pro Ile Asn Asn 
     450                 455                 460

 aaacagactt acttcgtatg ccctgccctt tattggtctc ccagacatgc aaactttgaa   1452

 gaagtttgaa gaaagttgtg gtccgttttt ttatggtcat taaatttgcc aaacataagg   1512

 cagtatttaa catctttgtc aaataaagca gatcattata aaaaaaaaaa              1562




      <210> 426
      <211> 633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(633)

      <400> 426
  atg cgg acc agg gcg ctc ccc att ccc gtc ggg agc ccg ccg att ggc      48
  Met Arg Thr Arg Ala Leu Pro Ile Pro Val Gly Ser Pro Pro Ile Gly
    1               5                  10                  15

 tgg gtg tgg gcg cac gtg acc gac atg tgg ctg tat tgg tgc agc ccg       96
 Trp Val Trp Ala His Val Thr Asp Met Trp Leu Tyr Trp Cys Ser Pro
              20                  25                  30

 cca ggg tgt cac tgg aga cag aat gga ggt gct gcc gga ctc gga aat      144
 Pro Gly Cys His Trp Arg Gln Asn Gly Gly Ala Ala Gly Leu Gly Asn
          35                  40                  45

 ggg agt gga ata aca gta tct aag gaa acg ggt aga gga caa caa aga      192
 Gly Ser Gly Ile Thr Val Ser Lys Glu Thr Gly Arg Gly Gln Gln Arg
      50                  55                  60

 atg gag cat att cat ggc gag gag caa aag ctc tac ccc att gaa agg      240
 Met Glu His Ile His Gly Glu Glu Gln Lys Leu Tyr Pro Ile Glu Arg
  65                  70                  75                  80

 ctt ctt ttc ctc cct ggc gac aag gac aca tgc att ggt ggc caa aag      288
 Leu Leu Phe Leu Pro Gly Asp Lys Asp Thr Cys Ile Gly Gly Gln Lys
                  85                  90                  95

 aga gag gag aca aaa ccg ctg cag atg gct gat gtg aat cta gtg gaa      336
 Arg Glu Glu Thr Lys Pro Leu Gln Met Ala Asp Val Asn Leu Val Glu
             100                 105                 110

 aga gct act ggg gat gag aga aag agg agg agg cag cga aga ata gcc      384
 Arg Ala Thr Gly Asp Glu Arg Lys Arg Arg Arg Gln Arg Arg Ile Ala
         115                 120                 125

 aga att cag caa atc gaa aag gac ata ctt cgt ata cga cag ctt tta      432
 Arg Ile Gln Gln Ile Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu
     130                 135                 140

 cag tcc caa gca aca gaa gca gag ttc ttt gac acc act gta tat cct      480
 Gln Ser Gln Ala Thr Glu Ala Glu Phe Phe Asp Thr Thr Val Tyr Pro
 145                 150                 155                 160

 cca gtt ggg ttc aat ttt gat cct aac tac cca gag tta gag tca gct      528
 Pro Val Gly Phe Asn Phe Asp Pro Asn Tyr Pro Glu Leu Glu Ser Ala
                 165                 170                 175

 cca caa gta aaa gac aaa gtc agt cac aag act gtc cac ttc aaa cgc      576
 Pro Gln Val Lys Asp Lys Val Ser His Lys Thr Val His Phe Lys Arg
             180                 185                 190

 cag cca caa gtt ttg ggt gtc cct aag cca cca gga ctg ctg cca agc      624
 Gln Pro Gln Val Leu Gly Val Pro Lys Pro Pro Gly Leu Leu Pro Ser
         195                 200                 205

 tgt cta taa                                                          633
 Cys Leu 
     210





      <210> 427
      <211> 2751
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(2751)

      <400> 427
 ctctcccatg atgttgcagg ctacccaggg cgcctttcca aggtgtttgt aaattgcccc     60

 caaacgtcag gtctgcagtt ggcatctcac cacttatgcc tgcgcttcac tgaggtccgc    120

 agggct   atg gag gct gag ctg aaa gca ctt cca agt gat tcc cca agg     168
          Met Glu Ala Glu Leu Lys Ala Leu Pro Ser Asp Ser Pro Arg
            1               5                  10

 aac gtc ctc aca gga gcg ttc aga ggg gcc cag cca gtg ctc ttg ctg      216
 Asn Val Leu Thr Gly Ala Phe Arg Gly Ala Gln Pro Val Leu Leu Leu
  15                  20                  25                  30

 ctg aag gag cat ccc agg gag tgt gtg aag cca aga tac cga aca agt      264
 Leu Lys Glu His Pro Arg Glu Cys Val Lys Pro Arg Tyr Arg Thr Ser
                  35                  40                  45

 cgg caa gag aca aaa acg ggg aga tgc cag gac gag cat ccg ttc tgc      312
 Arg Gln Glu Thr Lys Thr Gly Arg Cys Gln Asp Glu His Pro Phe Cys
              50                  55                  60

 tcc gca gtg gcc cgg ggg ccg gtg ttc ccg cag aca cca gca gct gat      360
 Ser Ala Val Ala Arg Gly Pro Val Phe Pro Gln Thr Pro Ala Ala Asp
          65                  70                  75

 ccg cgc aca gaa cag gac ccc ggc cac ggt gag gaa gag aga acg cgc      408
 Pro Arg Thr Glu Gln Asp Pro Gly His Gly Glu Glu Glu Arg Thr Arg
      80                  85                  90

 acg ctt cag atc tct ggt cgg agc gct gtt atg gag ttg gcg gtg gac      456
 Thr Leu Gln Ile Ser Gly Arg Ser Ala Val Met Glu Leu Ala Val Asp
  95                 100                 105                 110

 ctc acg agt gcc gag tgc att tgc tcc ccg ggg agg ctc gat gct cag      504
 Leu Thr Ser Ala Glu Cys Ile Cys Ser Pro Gly Arg Leu Asp Ala Gln
                 115                 120                 125

 gga ctc cag gcc tcg gcg tct gca gca gat aat cac aga ggc ttg cca      552
 Gly Leu Gln Ala Ser Ala Ser Ala Ala Asp Asn His Arg Gly Leu Pro
             130                 135                 140

 ggt ggc ctc cga aca ttg cta ata cac cag ctg cag ggg ctt cag cac      600
 Gly Gly Leu Arg Thr Leu Leu Ile His Gln Leu Gln Gly Leu Gln His
         145                 150                 155

 tgg aac acc acg tgg cac act gct ctc ctc aaa ggc tgc gag cgg ctg      648
 Trp Asn Thr Thr Trp His Thr Ala Leu Leu Lys Gly Cys Glu Arg Leu
     160                 165                 170

 agc gcc gtt cca gac act gct cca ccc ggc gag gga ctg cac tcc aag      696
 Ser Ala Val Pro Asp Thr Ala Pro Pro Gly Glu Gly Leu His Ser Lys
 175                 180                 185                 190

 gcg tta ctg ttg cca ctg ctg gcc gtg ccg gca gct ctc aca cat cag      744
 Ala Leu Leu Leu Pro Leu Leu Ala Val Pro Ala Ala Leu Thr His Gln
                 195                 200                 205

 cag aag atg gag atg gag ctc gtg aaa cag gag gat agg aag tcc atg      792
 Gln Lys Met Glu Met Glu Leu Val Lys Gln Glu Asp Arg Lys Ser Met
             210                 215                 220

 act ggc gag aac ttc agt caa aga act gga ccg cac cgc tgg cag gcg      840
 Thr Gly Glu Asn Phe Ser Gln Arg Thr Gly Pro His Arg Trp Gln Ala
         225                 230                 235

 cca agt caa tgt gga aag cag cac ccg gcc aac ccc agc cac aca cac      888
 Pro Ser Gln Cys Gly Lys Gln His Pro Ala Asn Pro Ser His Thr His
     240                 245                 250

 acc aca aac acc tat cag ccc ctc agt tca cat cct gct acc cac acc      936
 Thr Thr Asn Thr Tyr Gln Pro Leu Ser Ser His Pro Ala Thr His Thr
 255                 260                 265                 270

 atc cat gct tgg gtc aca acg tcc cct cca att cca ggg aac cct cct      984
 Ile His Ala Trp Val Thr Thr Ser Pro Pro Ile Pro Gly Asn Pro Pro
                 275                 280                 285

 tcc acc tcg tca caa tcg ctc ata gct gca gcc ttc tgg ggc cac ttc     1032
 Ser Thr Ser Ser Gln Ser Leu Ile Ala Ala Ala Phe Trp Gly His Phe
             290                 295                 300

 cac cag caa gca ggc cac gca ctg aag tac aca cat aca ctt cac gag     1080
 His Gln Gln Ala Gly His Ala Leu Lys Tyr Thr His Thr Leu His Glu
         305                 310                 315

 ttc ccc aac aga ggc cac aca ctt cag tac aca cac aca ctt cat gtg     1128
 Phe Pro Asn Arg Gly His Thr Leu Gln Tyr Thr His Thr Leu His Val
     320                 325                 330

 ttc cct gat gga ggc ctg gcg ctg cag tat gca cac ata ctt cac gtg     1176
 Phe Pro Asp Gly Gly Leu Ala Leu Gln Tyr Ala His Ile Leu His Val
 335                 340                 345                 350

 ttc cca gat gga ggc cac aca ctg tgg tac aca cac gca ctt cac gtg     1224
 Phe Pro Asp Gly Gly His Thr Leu Trp Tyr Thr His Ala Leu His Val
                 355                 360                 365

 ttc ccc gac gga ggc cac acg ctg tgg tac aca cac aca ctt cat gtg     1272
 Phe Pro Asp Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val
             370                 375                 380

 ttc cct gat gga ggc ccg gcg ctg cag tat gca cac aca ctt cac gtg     1320
 Phe Pro Asp Gly Gly Pro Ala Leu Gln Tyr Ala His Thr Leu His Val
         385                 390                 395

 ttc ccc gat gga ggc cac acg ctg tgg tac aca cac aca ctt cat gtg     1368
 Phe Pro Asp Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val
     400                 405                 410

 ttc cct gat gga ggc ccg gcg ctg cag tat gcg cac aca ctt cac gtg     1416
 Phe Pro Asp Gly Gly Pro Ala Leu Gln Tyr Ala His Thr Leu His Val
 415                 420                 425                 430

 ttc ccc gac gga ggc cac atg ctg tgg tac aca cac aca ctt cac atg     1464
 Phe Pro Asp Gly Gly His Met Leu Trp Tyr Thr His Thr Leu His Met
                 435                 440                 445

 ttc tct gac gga ggc cac acg ctg tgg tac aca cac aca ctt cac gtg     1512
 Phe Ser Asp Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val
             450                 455                 460

 ttc ccc gac gga ggc ccg gcg ctg cca tac aca cac aca ctt cac gtg     1560
 Phe Pro Asp Gly Gly Pro Ala Leu Pro Tyr Thr His Thr Leu His Val
         465                 470                 475

 ttc ccc gtt gga ggc cac acg ctg tgg tac aca cac aca ctt cac gtg     1608
 Phe Pro Val Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val
     480                 485                 490

 ttc tcc gac gga ggc cac agc gct gca gta cac aca cac act tca cgt     1656
 Phe Ser Asp Gly Gly His Ser Ala Ala Val His Thr His Thr Ser Arg
 495                 500                 505                 510

 gtt ctc cga cgg agg cca tgg cac cac tgc cgc tct cat gca tct gct     1704
 Val Leu Arg Arg Arg Pro Trp His His Cys Arg Ser His Ala Ser Ala
                 515                 520                 525

 gtc act gct cag tgt cgg ctc cct ggg ggc ggc gca cac tcg gtt ccc     1752
 Val Thr Ala Gln Cys Arg Leu Pro Gly Gly Gly Ala His Ser Val Pro
             530                 535                 540

 ttc ttg gtg tct gct ggg tgt ggg agt gtg gat gcc aat gtg ttg aat     1800
 Phe Leu Val Ser Ala Gly Cys Gly Ser Val Asp Ala Asn Val Leu Asn
         545                 550                 555

 gat aca ggc agg acg gaa gaa atg cct gga aca gtg gca cca act gct     1848
 Asp Thr Gly Arg Thr Glu Glu Met Pro Gly Thr Val Ala Pro Thr Ala
     560                 565                 570

 ctg gtc tca cac gtg ccc cga agc acg ttt acc ctg cag cac acc cgc     1896
 Leu Val Ser His Val Pro Arg Ser Thr Phe Thr Leu Gln His Thr Arg
 575                 580                 585                 590

 acc tgc tac caa gca gac ggc cac acg gac cac ctc tgc tgg ttc tcc     1944
 Thr Cys Tyr Gln Ala Asp Gly His Thr Asp His Leu Cys Trp Phe Ser
                 595                 600                 605

 aca aaa acc ggg acc atg gct gcc ctc cgt ctt tcc cat aaa ggt aat     1992
 Thr Lys Thr Gly Thr Met Ala Ala Leu Arg Leu Ser His Lys Gly Asn
             610                 615                 620

 gaa ttt tgg ggc act aca caa aca ctg aat gtt aaa ttt ctg cct tca     2040
 Glu Phe Trp Gly Thr Thr Gln Thr Leu Asn Val Lys Phe Leu Pro Ser
         625                 630                 635

 gat cct aat cac ttt att att ggc aca gac atg gaa gtg cag cca gga     2088
 Asp Pro Asn His Phe Ile Ile Gly Thr Asp Met Glu Val Gln Pro Gly
     640                 645                 650

 aag ccg gtg ctt gga gcc tgg ctc acc cgc cgc gga gct ggg gac ctc     2136
 Lys Pro Val Leu Gly Ala Trp Leu Thr Arg Arg Gly Ala Gly Asp Leu
 655                 660                 665                 670

 gtg cac gtc acc gag gct ctc cgg ggc tgt ttc cta atc tat gaa atg     2184
 Val His Val Thr Glu Ala Leu Arg Gly Cys Phe Leu Ile Tyr Glu Met
                 675                 680                 685

 tgg ttc ttt act cac agt cgt gga gag caa ggt ggg acc cag gcc ggc     2232
 Trp Phe Phe Thr His Ser Arg Gly Glu Gln Gly Gly Thr Gln Ala Gly
             690                 695                 700

 agc agc agc agc gaa ata gat caa cag aca aca ggg tgt tca gga ccc     2280
 Ser Ser Ser Ser Glu Ile Asp Gln Gln Thr Thr Gly Cys Ser Gly Pro
         705                 710                 715

 agt tca ggg ctg gag agg aca gag atc aac aaa gaa ctt ggt cat cgc     2328
 Ser Ser Gly Leu Glu Arg Thr Glu Ile Asn Lys Glu Leu Gly His Arg
     720                 725                 730

 caa gga gcc cga tgc cgg cct cag cac cac gct gtc tcc gct gcc gct     2376
 Gln Gly Ala Arg Cys Arg Pro Gln His His Ala Val Ser Ala Ala Ala
 735                 740                 745                 750

 tta act gtg gac gtg gtg acc agc agc ctt cca gag gtg gcc cct cca     2424
 Leu Thr Val Asp Val Val Thr Ser Ser Leu Pro Glu Val Ala Pro Pro
                 755                 760                 765

 gga acg gtg gca tca gct ctg tgc agg gag gac agc tgc tcc cag acg     2472
 Gly Thr Val Ala Ser Ala Leu Cys Arg Glu Asp Ser Cys Ser Gln Thr
             770                 775                 780

 aag gga gga ggc ctg ggt ccc cac aca gtc cct gat tca ggg tcg tgc     2520
 Lys Gly Gly Gly Leu Gly Pro His Thr Val Pro Asp Ser Gly Ser Cys
         785                 790                 795

 tgg aca cgt att ctg cac ggg gca gat tat gcg gat ttt agc ctt gtg     2568
 Trp Thr Arg Ile Leu His Gly Ala Asp Tyr Ala Asp Phe Ser Leu Val
     800                 805                 810

 gat cct aca gcc gca gcc aca gaa aga tgg aga caa ggg cac gtg gct     2616
 Asp Pro Thr Ala Ala Ala Thr Glu Arg Trp Arg Gln Gly His Val Ala
 815                 820                 825                 830

 gtg tcc cag gaa aac tct ctc tac agc tgc cgg cca ctt ctg gcc gcc     2664
 Val Ser Gln Glu Asn Ser Leu Tyr Ser Cys Arg Pro Leu Leu Ala Ala
                 835                 840                 845

 tcc cgg tct aga cgc tca cat gag aga aaa aca gat tta aaa aat cat     2712
 Ser Arg Ser Arg Arg Ser His Glu Arg Lys Thr Asp Leu Lys Asn His
             850                 855                 860

 tta agc cat tgc ctc aag gcc att tca caa atc caa tga                 2751
 Leu Ser His Cys Leu Lys Ala Ile Ser Gln Ile Gln 
         865                 870





      <210> 428
      <211> 281
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(234)

      <400> 428
 ttctttgtcc agtcctagaa atgtgctgaa caaaggaggt gggtgggagg gatatgccca     60

 caacctaaag aaacaaccag ttaaaacatt tacagcaatc tt   atg ttt ttc cct     114
                                                  Met Phe Phe Pro
                                                    1

 ttg ttc agg tta cta ctt tgg gat tgt gat gat cga agc tat agc tac      162
 Leu Phe Arg Leu Leu Leu Trp Asp Cys Asp Asp Arg Ser Tyr Ser Tyr
   5                  10                  15                  20

 tac gtt gag gtt tct acc aac cag caa cag tgg acc atg gtt gct gac      210
 Tyr Val Glu Val Ser Thr Asn Gln Gln Gln Trp Thr Met Val Ala Asp
                  25                  30                  35

 aga act aaa gtc tcc tgc aag taa gttgtgtctt ttcaggaatt tattcctatt     264
 Arg Thr Lys Val Ser Cys Lys 
              40

 gaaaagacag tcttccc                                                   281




      <210> 429
      <211> 438
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(376)

      <400> 429
 cgagagaaga aagtataaaa gcagaaggaa tgaggaagta ataaagaatg agtaattaaa     60

 tgagcaaatg ataagttgct taaaatcggc tttatcttag gaggagaaag aactaacaga    120

 g    atg cag aag tcc tct tct act cgg gct ggg gat atg cgt gag aaa     166
      Met Gln Lys Ser Ser Ser Thr Arg Ala Gly Asp Met Arg Glu Lys
        1               5                  10                  15

 gac acg cgt gga tgc cgt atg agc tct cgt tct gaa tgc gga aat ctg      214
 Asp Thr Arg Gly Cys Arg Met Ser Ser Arg Ser Glu Cys Gly Asn Leu
                  20                  25                  30

 acc tcc cac cgg ata ctc agt tca ggg ggc tcc tgg acc ctc cag ctg      262
 Thr Ser His Arg Ile Leu Ser Ser Gly Gly Ser Trp Thr Leu Gln Leu
              35                  40                  45

 ctc ctc tac tca tcg ctc cct cac tca gaa aac cag cag aga agt gaa      310
 Leu Leu Tyr Ser Ser Leu Pro His Ser Glu Asn Gln Gln Arg Ser Glu
          50                  55                  60

 ctt cct caa atg act gac ggt aaa tat cca gca tgg agc tgg att aca      358
 Leu Pro Gln Met Thr Asp Gly Lys Tyr Pro Ala Trp Ser Trp Ile Thr
      65                  70                  75

 aaa ctg tat aaa ctg taa atagca tcacgctatt ccctttaaag aagtgtcagt      412
 Lys Leu Tyr Lys Leu 
  80

 ctcgaatcgt gaccgggaag tcgggc                                         438




      <210> 430
      <211> 1375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(1328)

      <400> 430
 cgcagcgccc agcagcaccc ggagtcgctt ggacgccggt tcggggctat tgcggggtgg     60

 cgtcgctggg cccgggaaag ttcgggactg gagagtggcg acgccgggcg gcgggaccc     119                                                                 
 atg gag gcg cgc ggg gag ctg ggc ccg gcc cgg gag tcg gcg gga ggc      167
 Met Glu Ala Arg Gly Glu Leu Gly Pro Ala Arg Glu Ser Ala Gly Gly
   1               5                  10                  15

 gac ctg ctg cta gca ctg ctg gcg cgg agg gca gac ctg cgc cga gag      215
 Asp Leu Leu Leu Ala Leu Leu Ala Arg Arg Ala Asp Leu Arg Arg Glu
              20                  25                  30

 atc ccg ctg tgc gct ggc tgt gac cag cac atc ctg gac cgc ttc atc      263
 Ile Pro Leu Cys Ala Gly Cys Asp Gln His Ile Leu Asp Arg Phe Ile
          35                  40                  45

 ctc aag gct ctg gac cgc cac tgg cac agc aag tgt ctc aag tgc agc      311
 Leu Lys Ala Leu Asp Arg His Trp His Ser Lys Cys Leu Lys Cys Ser
      50                  55                  60

 gac tgc cac acg cca ctg gcc gag cgc tgc ttc agc cga ggg gag agc      359
 Asp Cys His Thr Pro Leu Ala Glu Arg Cys Phe Ser Arg Gly Glu Ser
  65                  70                  75                  80

 gtt tac tgc aag gac gac ttt ttc aag cgc ttc ggg acc aag tgc gcc      407
 Val Tyr Cys Lys Asp Asp Phe Phe Lys Arg Phe Gly Thr Lys Cys Ala
                  85                  90                  95

 gcg tgc cag ctg ggc atc ccg ccc acg cag gtg gtg cgc cgc gcc cag      455
 Ala Cys Gln Leu Gly Ile Pro Pro Thr Gln Val Val Arg Arg Ala Gln
             100                 105                 110

 gac ttc gtg tac cac ctg cac tgc ttt gcc tgc gtc gtg tgc aag cgg      503
 Asp Phe Val Tyr His Leu His Cys Phe Ala Cys Val Val Cys Lys Arg
         115                 120                 125

 cag ctg gcc acg ggc gac gag ttc tac ctc atg gag gac agc cgg ctc      551
 Gln Leu Ala Thr Gly Asp Glu Phe Tyr Leu Met Glu Asp Ser Arg Leu
     130                 135                 140

 gtg tgc aag gcg gac tac gaa acc gcc aag cag cga gag gcc gag gcc      599
 Val Cys Lys Ala Asp Tyr Glu Thr Ala Lys Gln Arg Glu Ala Glu Ala
 145                 150                 155                 160

 acg gcc aag cgg ccg cgc acg acc atc acc gcc aag cag ctg gag acg      647
 Thr Ala Lys Arg Pro Arg Thr Thr Ile Thr Ala Lys Gln Leu Glu Thr
                 165                 170                 175

 ctg aag agc gct tac aac acc tcg ccc aag ccg gcg cgc cac gtg cgc      695
 Leu Lys Ser Ala Tyr Asn Thr Ser Pro Lys Pro Ala Arg His Val Arg
             180                 185                 190

 gag cag ctc tcg tcc gag acg ggc ctg gac atg cgc gtg gtg cag gtt      743
 Glu Gln Leu Ser Ser Glu Thr Gly Leu Asp Met Arg Val Val Gln Val
         195                 200                 205

 tgg ttc cag aac cgc cgg gcc aag gag aag agg ctg aag aag gac gcc      791
 Trp Phe Gln Asn Arg Arg Ala Lys Glu Lys Arg Leu Lys Lys Asp Ala
     210                 215                 220

 ggc cgg cag cgc tgg ggg cag tat ttc cgc aac atg aag cgc tcc cgc      839
 Gly Arg Gln Arg Trp Gly Gln Tyr Phe Arg Asn Met Lys Arg Ser Arg
 225                 230                 235                 240

 ggc ggc tcc aag tcg gac aag gac agc gtt cag gag ggg cag gac agc      887
 Gly Gly Ser Lys Ser Asp Lys Asp Ser Val Gln Glu Gly Gln Asp Ser
                 245                 250                 255

 gac gct gag gtc tcc ttc ccc gat gag cct tcc ttg gcg gaa atg ggc      935
 Asp Ala Glu Val Ser Phe Pro Asp Glu Pro Ser Leu Ala Glu Met Gly
             260                 265                 270

 ccg gcc aat ggc ctc tac ggg agc ttg ggg gaa ccc acc cag gcc ttg      983
 Pro Ala Asn Gly Leu Tyr Gly Ser Leu Gly Glu Pro Thr Gln Ala Leu
         275                 280                 285

 ggc cgg ccc tcg gga gcc ctg ggc aac ttc tcc ctg gag cat gga ggc     1031
 Gly Arg Pro Ser Gly Ala Leu Gly Asn Phe Ser Leu Glu His Gly Gly
     290                 295                 300

 ctg gca ggc cca gag cag tac cga gag ctg cgt ccc ggc agc ccc tac     1079
 Leu Ala Gly Pro Glu Gln Tyr Arg Glu Leu Arg Pro Gly Ser Pro Tyr
 305                 310                 315                 320

 ggt gtc ccc cca tcc ccc gcc gcc ccg cag agc ctc cct ggc ccc cag     1127
 Gly Val Pro Pro Ser Pro Ala Ala Pro Gln Ser Leu Pro Gly Pro Gln
                 325                 330                 335

 ccc ctc ctc tcc agc ctg gtg tac cca gac acc agc ttg ggc ctt gtg     1175
 Pro Leu Leu Ser Ser Leu Val Tyr Pro Asp Thr Ser Leu Gly Leu Val
             340                 345                 350

 ccc tcg gga gcc ccc ggc ggg ccc cca ccc atg agg gtg ctg gca ggg     1223
 Pro Ser Gly Ala Pro Gly Gly Pro Pro Pro Met Arg Val Leu Ala Gly
         355                 360                 365

 aac gga ccc agt tct gac cta tcc acg ggg agc agc ggg ggt tac ccc     1271
 Asn Gly Pro Ser Ser Asp Leu Ser Thr Gly Ser Ser Gly Gly Tyr Pro
     370                 375                 380

 gac ttc cct gcc agc ccc gcc tcc tgg ctg gat gag gta gac cac gct     1319
 Asp Phe Pro Ala Ser Pro Ala Ser Trp Leu Asp Glu Val Asp His Ala
 385                 390                 395                 400

 cag ttc tga cccaggc ccggctccac cctgcacctc acacgaggga gctgcccctg     1375
 Gln Phe 






      <210> 431
      <211> 1456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (437)..(1129)

      <400> 431
 aatgaacatt ttcatcctca gcatccatct ccgagacaag gtcggggata tgggatgccc     60

 aggaattcat ctcggtttat aaacaggcac aacatgccgg gccctaaagt tgatttttac    120

 ccaggcccag gtaaaaggtg ctgccagagc tatgataact tctcttatag atctcgttca    180

 tttagacgta gtcaccgcca gatgagttgt gtgaataagg agtcccagta tggatttacc    240

 ccagggaatg gacagatgcc caggggcttg gaagaaacta ttacttttta tgaagttgaa    300

 gaaggggatg agactgctta tccaacttta cctaatcatg gaggtccctc tacaatggtt    360

 cctgctactt caggatactg tgttggaagg cggggacata gctcaggcaa acagactttg    420

 aatttagagg agggca    atg gcc aga gtg aaa atg ggc gat atc atg aag     469
                      Met Ala Arg Val Lys Met Gly Asp Ile Met Lys
                        1               5                  10

 aat atc ttt atc gtg cag agc cag act atg aaa ctt cag gtg ttt ata      517
 Asn Ile Phe Ile Val Gln Ser Gln Thr Met Lys Leu Gln Val Phe Ile
              15                  20                  25

 gca caa ctg cat cta cag caa act tgt ctc ttc agg aca aga aag tca      565
 Ala Gln Leu His Leu Gln Gln Thr Cys Leu Phe Arg Thr Arg Lys Ser
          30                  35                  40

 tgt tct atg tct cct cag gac aca gtt acc tca tac aac tac ccc cag      613
 Cys Ser Met Ser Pro Gln Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln
      45                  50                  55

 aag atg atg gga aat att gca gca gtt gca gct tcc tgt gcc aat aat      661
 Lys Met Met Gly Asn Ile Ala Ala Val Ala Ala Ser Cys Ala Asn Asn
  60                  65                  70                  75

 gtt cca gct cca gtc tta tct aac ggt gca gcg gct aat caa gct att      709
 Val Pro Ala Pro Val Leu Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile
                  80                  85                  90

 agt acc act tca gtt tcc tca cag aat gct ata cag cct ctc ttt gta      757
 Ser Thr Thr Ser Val Ser Ser Gln Asn Ala Ile Gln Pro Leu Phe Val
              95                 100                 105

 tct cca cct aca cac ggc agg cca gtg att gcc tca cca tcc tat cca      805
 Ser Pro Pro Thr His Gly Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro
         110                 115                 120

 tgc cat tct gct att cct cat gct ggt gcc tct tta cca caa cca cca      853
 Cys His Ser Ala Ile Pro His Ala Gly Ala Ser Leu Pro Gln Pro Pro
     125                 130                 135

 cca cca cca cca cca cca cca cca cca cca cca cct cct cct cct cct      901
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
 140                 145                 150                 155

 cct cct cct cct cct cct cct gct ctt gat gtg gga gag act tca aac      949
 Pro Pro Pro Pro Pro Pro Pro Ala Leu Asp Val Gly Glu Thr Ser Asn
                 160                 165                 170

 tta caa cca cca cca cca cta cca cct cca cct tat tcc tgt gat cca      997
 Leu Gln Pro Pro Pro Pro Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro
             175                 180                 185

 agc ggc agt gat ttg cct caa gat aca aaa gtt ttg cag tac tat ttc     1045
 Ser Gly Ser Asp Leu Pro Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe
         190                 195                 200

 aat cta gga ttg cag tgc tat tac cac agc tac tgg cac tca tgg tct     1093
 Asn Leu Gly Leu Gln Cys Tyr Tyr His Ser Tyr Trp His Ser Trp Ser
     205                 210                 215

 atg tgc cac aga tgc agc agc agc agc ttc atg tag agat atcagtctat     1143
 Met Cys His Arg Cys Ser Ser Ser Ser Phe Met 
 220                 225                 230

 actgagccac ctctggtaga tcaaaccgtt cctcaatgct acagtgaggt gaggagagaa   1203

 gatggcatac aggcggaagg catcagcaaa tgatactttt ccgaatgctg attcttcatc   1263

 tgtccctcat ggagcagtct attatccagt aatgtcagat ccctatgggc agccaccttt   1323

 gccaggtttt gactcctgct tccggttgtg ccagattatt tctgtgttcc cccctggcat   1383

 ccagttggta cagcatatgg tggttcttct caaattcatg gtgctataaa tcctgggccc   1443

 gaatcgcggc cgc                                                      1456




      <210> 432
      <211> 2935
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (315)..(1772)

      <400> 432
 tttcgtgact attctctggc agctccccga atcctttctc cgaagatgtc aaacggcccc     60

 cagcgcccct ggtaactgac aaggaggcca ggaagaaggt tctcaaacaa gctttttcag    120

 ccaaccaagt gccggagaag ctggatgtgg tggtaattgg cagtggcttt gggggcctgg    180

 ctgcagctgc aattctagct aaagctggca agcgagtcct ggtgctggaa caacatacca    240

 aggcaggggg ctgctgtcat acctttggaa agaatggcct tgaatttgac acaggaatcc    300

 attacattgg gcgt  atg gaa gag ggc agc att ggc cgt ttt atc ttg gac     350
                  Met Glu Glu Gly Ser Ile Gly Arg Phe Ile Leu Asp
                    1               5                  10

 cag atc act gaa ggg cag ctg gac tgg gct ccc ctg tcc tct cct ttt      398
 Gln Ile Thr Glu Gly Gln Leu Asp Trp Ala Pro Leu Ser Ser Pro Phe
          15                  20                  25

 gac atc atg gta ctg gaa ggg ccc aat ggc cga aag gag tac ccc atg      446
 Asp Ile Met Val Leu Glu Gly Pro Asn Gly Arg Lys Glu Tyr Pro Met
      30                  35                  40

 tac agt gga gag aaa gcc tac att cag ggc ctc aag gag aag ttt cca      494
 Tyr Ser Gly Glu Lys Ala Tyr Ile Gln Gly Leu Lys Glu Lys Phe Pro
  45                  50                  55                  60

 cag gag gaa gct atc att gac aag tat ata aag ctg gtt aag gtg gta      542
 Gln Glu Glu Ala Ile Ile Asp Lys Tyr Ile Lys Leu Val Lys Val Val
                  65                  70                  75

 tcc agt gga gcc cct cat gcc atc ctg ttg aaa ttc ctc cca ttg ccc      590
 Ser Ser Gly Ala Pro His Ala Ile Leu Leu Lys Phe Leu Pro Leu Pro
              80                  85                  90

 gtg gtt cag ctc ctc gac agg tgt ggg ctg ctg act cgt ttc tct cca      638
 Val Val Gln Leu Leu Asp Arg Cys Gly Leu Leu Thr Arg Phe Ser Pro
          95                 100                 105

 ttc ctt caa gca tcc acc cag agc ctg gct gag gtc ctg cag cag ctg      686
 Phe Leu Gln Ala Ser Thr Gln Ser Leu Ala Glu Val Leu Gln Gln Leu
     110                 115                 120

 ggg gcc tcc tct gag ctc cag gca gta ctc agc tac atc ttc ccc act      734
 Gly Ala Ser Ser Glu Leu Gln Ala Val Leu Ser Tyr Ile Phe Pro Thr
 125                 130                 135                 140

 tac ggt gtc acc ccc aac cac agt gcc ttt tcc atg cac gcc ctg ctg      782
 Tyr Gly Val Thr Pro Asn His Ser Ala Phe Ser Met His Ala Leu Leu
                 145                 150                 155

 gtc aac cac tac atg aaa gga ggc ttt tat ccc cga ggg ggt tcc agt      830
 Val Asn His Tyr Met Lys Gly Gly Phe Tyr Pro Arg Gly Gly Ser Ser
             160                 165                 170

 gaa att gcc ttc cac acc atc cct gtg att cag cgg gct ggg ggc gct      878
 Glu Ile Ala Phe His Thr Ile Pro Val Ile Gln Arg Ala Gly Gly Ala
         175                 180                 185

 gtc ctc aca aag gcc act gtg cag agt gtg ttg ctg gac tca gct ggg      926
 Val Leu Thr Lys Ala Thr Val Gln Ser Val Leu Leu Asp Ser Ala Gly
     190                 195                 200

 aaa gcc tgt ggt gtc agt gtg aag aag ggg cat gag ctg gtg aac atc      974
 Lys Ala Cys Gly Val Ser Val Lys Lys Gly His Glu Leu Val Asn Ile
 205                 210                 215                 220

 tat tgc ccc atc gtg gtc tcc aac gca gga ctg ttc aac acc tat gaa     1022
 Tyr Cys Pro Ile Val Val Ser Asn Ala Gly Leu Phe Asn Thr Tyr Glu
                 225                 230                 235

 cac cta ctg ccg ggg aac gcc cgc tgc ctg cca ggt gtg aag cag caa     1070
 His Leu Leu Pro Gly Asn Ala Arg Cys Leu Pro Gly Val Lys Gln Gln
             240                 245                 250

 ctg ggg acg gtg cgg ccc ggc tta ggc atg acc tct gtt ttc atc tgc     1118
 Leu Gly Thr Val Arg Pro Gly Leu Gly Met Thr Ser Val Phe Ile Cys
         255                 260                 265

 ctg cga ggc acc aag gaa gac ctg cat ctg ccg tcc acc aac tac tat     1166
 Leu Arg Gly Thr Lys Glu Asp Leu His Leu Pro Ser Thr Asn Tyr Tyr
     270                 275                 280

 gtt tac tat gac acg gac atg gac cag gcg atg gag cgc tac gtc tcc     1214
 Val Tyr Tyr Asp Thr Asp Met Asp Gln Ala Met Glu Arg Tyr Val Ser
 285                 290                 295                 300

 atg ccc agg gaa gag gct gcg gaa cac atc cct ctt ctc ttc ttc gct     1262
 Met Pro Arg Glu Glu Ala Ala Glu His Ile Pro Leu Leu Phe Phe Ala
                 305                 310                 315

 ttc cca tca gcc aaa gat ccg acc tgg gag gac cga ttc cca ggc cgg     1310
 Phe Pro Ser Ala Lys Asp Pro Thr Trp Glu Asp Arg Phe Pro Gly Arg
             320                 325                 330

 tcc acc atg atc atg ctc ata ccc act gcc tac gag tgg ttt gag gag     1358
 Ser Thr Met Ile Met Leu Ile Pro Thr Ala Tyr Glu Trp Phe Glu Glu
         335                 340                 345

 tgg cag gcg gag ctg aag gga aag cgg ggc agt gac tat gag acc ttc     1406
 Trp Gln Ala Glu Leu Lys Gly Lys Arg Gly Ser Asp Tyr Glu Thr Phe
     350                 355                 360

 aaa aac tcc ttt gtg gaa gcc tct atg tca gtg gtc ctg aaa ctg ttc     1454
 Lys Asn Ser Phe Val Glu Ala Ser Met Ser Val Val Leu Lys Leu Phe
 365                 370                 375                 380

 cca cag ctg gag ggg aag gtg gag agt gtg act gca gga tcc cca ctc     1502
 Pro Gln Leu Glu Gly Lys Val Glu Ser Val Thr Ala Gly Ser Pro Leu
                 385                 390                 395

 acc aac cag ttc tat ctg gct gct ccc cga ggt gcc tgc tac ggg gct     1550
 Thr Asn Gln Phe Tyr Leu Ala Ala Pro Arg Gly Ala Cys Tyr Gly Ala
             400                 405                 410

 gac cat gac ctg ggc cgc ctg cac cct tgt gtg atg gcc tcc ttg agg     1598
 Asp His Asp Leu Gly Arg Leu His Pro Cys Val Met Ala Ser Leu Arg
         415                 420                 425

 gcc cag agc ccc atc ccc aac ctc tat ctg aca ggc cag gat atc ttc     1646
 Ala Gln Ser Pro Ile Pro Asn Leu Tyr Leu Thr Gly Gln Asp Ile Phe
     430                 435                 440

 acc tgt gga ctg gtc ggg gcc ctg caa ggt gcc ctg ctg tgc agc agc     1694
 Thr Cys Gly Leu Val Gly Ala Leu Gln Gly Ala Leu Leu Cys Ser Ser
 445                 450                 455                 460

 acc atc ctg aag cgg aac ttg tac tca gac ctt aag aat ctt gat tct     1742
 Thr Ile Leu Lys Arg Asn Leu Tyr Ser Asp Leu Lys Asn Leu Asp Ser
                 465                 470                 475

 agg atc cgg gca cag aag aaa aag aat tag t tccatcaggg aggagtcaga     1793
 Arg Ile Arg Ala Gln Lys Lys Lys Asn 
             480                 485

 ggaatttgcc caatggctgg ggcatctccc ttgacttacc cataatgtct ttctgcatta   1853

 gttccttgca tgtataaagc actctaattt ggttctgatg cctgaagaga ggcctagttt   1913

 aaatcacaat tccgaatctg gggcaatgga atcactgctt ccagctgggg caggtgagat   1973

 ctttacgcct tttataacat gccatcccta ctaataggat attgacttgg atagcttgat   2033

 gtctcatgac gagcggcgct ctgcatccct cacccatgcc tcctaactca gtgatcaaag   2093

 cgaatattcc atctgtggat agaacccctg gcagtgttgt cagctcaacc tggtgggttc   2153

 agttctgtcc tgaggcttct gctctcattc atttagtgct acgctgcaca gttctacact   2213

 gtcaagggaa aagggagact aatgaggctt aactcaaaac ctgggcatgg ttttggttgc   2273

 cattccatag gtttggagag ctctagatct cttttgtgct gggttcagtg gctcttcagg   2333

 ggacaggaaa tgcctgtgtc tggccagtgt ggttctggag ctttggggta acagcaggat   2393

 ccatcagtta gtagggtgca tgtcagatga tcatatccaa ttcatatgga agtcccgggt   2453

 ctgtcttcct tatcatcggg gtggcagctg gttctcaatg tgccagcagg gactcagtac   2513

 ctgagcctca atcaagcctt atccaccaaa tacacaggga agggtgatgc agggaagggt   2573

 gacatcagga gtcagggcat ggactggtaa gatgaatact ttgctgggct gaagcaggct   2633

 gcagggcatt ccagccaagg gcacagcagg ggacagtgca gggaggtgtg gggtaaggga   2693

 gggaagtcac atcagaaaag ggaaagccac ggaatgtgtg tgaagcccag aaatggcatt   2753

 tgcagttaat tagcacatgt gagggttaga caggtaggtg aatgcaagct caaggtttgg   2813

 aaaaatgact tttcagttat gtctttggta tcagacatac gaaaggtctc tttgtagttc   2873

 gtgttaatgt aacattaata aatttattga ttccattgct ttaacatttg aaaaaaaaaa   2933

 aa                                                                  2935




      <210> 433
      <211> 1499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(1167)

      <400> 433
 atgccaaagg cagcttccaa aggcgtgtca aggaatggag tggaaatgag ctgtttaaag     60

 cctcagtgca gcagtgatat caccagcgag ttgagtacca caattattca aggcagtcca    120

 gccgcattgg aggaacgggc t  atg gaa aaa ttg aga gaa aaa gtt cca ttt     171
                          Met Glu Lys Leu Arg Glu Lys Val Pro Phe
                            1               5                  10

 cag aat aga gga aaa gga aca tta tca tct att atc ccg aat aac tct      219
 Gln Asn Arg Gly Lys Gly Thr Leu Ser Ser Ile Ile Pro Asn Asn Ser
                  15                  20                  25

 gat aca aga aaa gca act gaa act act tct ctg agt agc aag cct gaa      267
 Asp Thr Arg Lys Ala Thr Glu Thr Thr Ser Leu Ser Ser Lys Pro Glu
              30                  35                  40

 tat gta aat cct gac ttt aga tgg agt aaa gat cct tcc tcc aaa agt      315
 Tyr Val Asn Pro Asp Phe Arg Trp Ser Lys Asp Pro Ser Ser Lys Ser
          45                  50                  55

 gga aat ctg ttg gaa acc agt gag gta ggt tgg aca tca aac cct gag      363
 Gly Asn Leu Leu Glu Thr Ser Glu Val Gly Trp Thr Ser Asn Pro Glu
      60                  65                  70

 gaa ttg gac ccg atc agg ctg gct ctc ctg ggc aag tca ggt ctg agc      411
 Glu Leu Asp Pro Ile Arg Leu Ala Leu Leu Gly Lys Ser Gly Leu Ser
  75                  80                  85                  90

 tgt cag gtg ggg tca gcc aca tca cac cct gtg tcc tgc cag gag cct      459
 Cys Gln Val Gly Ser Ala Thr Ser His Pro Val Ser Cys Gln Glu Pro
                  95                 100                 105

 ata gat gaa gat caa aga ata agt cct aaa gat aag tca act gct ggc      507
 Ile Asp Glu Asp Gln Arg Ile Ser Pro Lys Asp Lys Ser Thr Ala Gly
             110                 115                 120

 cgt gag ttc agt ggc cag gtt tct cat cag acc acc tct gaa aac cag      555
 Arg Glu Phe Ser Gly Gln Val Ser His Gln Thr Thr Ser Glu Asn Gln
         125                 130                 135

 tgt act cct att ccc agc agc aca gtt cac agc tct gtg gct gac atg      603
 Cys Thr Pro Ile Pro Ser Ser Thr Val His Ser Ser Val Ala Asp Met
     140                 145                 150

 cag aac atg cct gct gct gtg cat gca ctc ttg aca caa ccc tct ctc      651
 Gln Asn Met Pro Ala Ala Val His Ala Leu Leu Thr Gln Pro Ser Leu
 155                 160                 165                 170

 agc gct gct cct ttt gct cag cgg tat ttg gga aca ctc cct tca act      699
 Ser Ala Ala Pro Phe Ala Gln Arg Tyr Leu Gly Thr Leu Pro Ser Thr
                 175                 180                 185

 gga agc acc acc ttg cct cag tgc cat gct ggc aat gcc aca gtc tgt      747
 Gly Ser Thr Thr Leu Pro Gln Cys His Ala Gly Asn Ala Thr Val Cys
             190                 195                 200

 ggc ttc tca gga ggc ctt ccc tat cca gct gtt gca gga gag cct gtg      795
 Gly Phe Ser Gly Gly Leu Pro Tyr Pro Ala Val Ala Gly Glu Pro Val
         205                 210                 215

 cag aac tct gtg gct gtg gga att tgt cta gga tca aat atc ggc tct      843
 Gln Asn Ser Val Ala Val Gly Ile Cys Leu Gly Ser Asn Ile Gly Ser
     220                 225                 230

 gga tgg atg ggt acc tct tcc ctc tgt aac cca tat tct aat acc tta      891
 Gly Trp Met Gly Thr Ser Ser Leu Cys Asn Pro Tyr Ser Asn Thr Leu
 235                 240                 245                 250

 aat cag aac ctg cta agc aca aca aaa cct ttt cct gtg ccg tct gtt      939
 Asn Gln Asn Leu Leu Ser Thr Thr Lys Pro Phe Pro Val Pro Ser Val
                 255                 260                 265

 ggt aca aac tgt gga att gaa cca tgg gat tca gga gtg aca tca gga      987
 Gly Thr Asn Cys Gly Ile Glu Pro Trp Asp Ser Gly Val Thr Ser Gly
             270                 275                 280

 ttg ggg agt gtc cga gtg ccc gag gag ttg aag ctt cct cat gct tgc     1035
 Leu Gly Ser Val Arg Val Pro Glu Glu Leu Lys Leu Pro His Ala Cys
         285                 290                 295

 tgt gtc ggg atc gct tcc cag acc ctc ctc agt gtg ctt aat cca act     1083
 Cys Val Gly Ile Ala Ser Gln Thr Leu Leu Ser Val Leu Asn Pro Thr
     300                 305                 310

 gac cgc tgg ctg caa gtc agc att ggg gtc ctc agc att agt gtt aat     1131
 Asp Arg Trp Leu Gln Val Ser Ile Gly Val Leu Ser Ile Ser Val Asn
 315                 320                 325                 330

 ggt gaa aag gta gct ttc tat gtc ttt ctc att taa ccta acagttgcat     1181
 Gly Glu Lys Val Ala Phe Tyr Val Phe Leu Ile 
                 335                 340

 tgtgattagg tgcttgattt cccccatctc tagtgctagg ttctcccttc acgcctttat   1241

 taatgcacac agtcattgcc atggtatctt tctctcagac cccttttgtt gtagtgcttg   1301

 tagagtgtaa agtgaaacag ttttgcattt tccatcattt attatttata ttttattgtt   1361

 atttattggt aaattcctat aaatttgctt ttagtgctat tatttaaatc atcaaaagtt   1421

 ctgagtttct tgtttctact tgtcagtttt gttaaaggtg attgaatata agtaaccatg   1481

 acttgtaaaa aaaaaaaa                                                 1499




      <210> 434
      <211> 2349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1868)

      <400> 434
 ccaag    atg gcg gca gcg acg gca gac ccg gga gct ggg aac ccg cag      47
          Met Ala Ala Ala Thr Ala Asp Pro Gly Ala Gly Asn Pro Gln
            1               5                  10

 cct ggg gac tcc tcc ggc ggg ggc gct ggg ggc ggg ctg ccg tcc cct       95
 Pro Gly Asp Ser Ser Gly Gly Gly Ala Gly Gly Gly Leu Pro Ser Pro
  15                  20                  25                  30

 ggg gag cag gag ctg agc cgg cgc ttg cag cgc ctg tat ccc gcg gtc      143
 Gly Glu Gln Glu Leu Ser Arg Arg Leu Gln Arg Leu Tyr Pro Ala Val
                  35                  40                  45

 aac cag caa gag act ccg ctg ccg cgc tcc tgg agc ccc aag gac aaa      191
 Asn Gln Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys
              50                  55                  60

 tac aac tac att ggt ctc tcc cag ggc aac ctc cgc gtc cac tac aaa      239
 Tyr Asn Tyr Ile Gly Leu Ser Gln Gly Asn Leu Arg Val His Tyr Lys
          65                  70                  75

 ggt cat ggc aaa aat cac aaa gat gcg gcc tca gtg cgt gcc acc cac      287
 Gly His Gly Lys Asn His Lys Asp Ala Ala Ser Val Arg Ala Thr His
      80                  85                  90

 ccc ata cct gct gcc tgt ggc att tat tac ttt gaa gtg aag att gtc      335
 Pro Ile Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val
  95                 100                 105                 110

 agc aaa gga aga gat ggt tac atg gga ata gga ctc tcg gct caa ggc      383
 Ser Lys Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly
                 115                 120                 125

 gtc aac atg aac aga ctt cct ggt tgg gac aaa cat tcc tat ggt tac      431
 Val Asn Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr
             130                 135                 140

 cat ggt gat gat ggg cat tcg ttc tgc tcc tcg ggg act ggc cag ccc      479
 His Gly Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro
         145                 150                 155

 tat ggt ccc aca ttc acc aca gga gac gtg atc ggc tgc tgt gtc aac      527
 Tyr Gly Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn
     160                 165                 170

 ctc atc aat ggc acc tgc ttc tac acc aag aat ggc cac agc ctt ggt      575
 Leu Ile Asn Gly Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly
 175                 180                 185                 190

 ata gcc ttc aca gac ctc ccg gcc aac ctc tac ccc acc gta ggc ctg      623
 Ile Ala Phe Thr Asp Leu Pro Ala Asn Leu Tyr Pro Thr Val Gly Leu
                 195                 200                 205

 cag aca cct ggg gag att gtg gac gcc aac ttt ggg cag cag ccc ttc      671
 Gln Thr Pro Gly Glu Ile Val Asp Ala Asn Phe Gly Gln Gln Pro Phe
             210                 215                 220

 ctg ttt gac att gag gac tac atg cgg gag tgg cgt gcc aag gtc cag      719
 Leu Phe Asp Ile Glu Asp Tyr Met Arg Glu Trp Arg Ala Lys Val Gln
         225                 230                 235

 ggc acg gtc cac tgc ttc ccc atc agt gcc cgg ctt ggc gag tgg cag      767
 Gly Thr Val His Cys Phe Pro Ile Ser Ala Arg Leu Gly Glu Trp Gln
     240                 245                 250

 gca gtg ctg cag aac atg gtt tca tct tac ctc gtg cat cat ggg tat      815
 Ala Val Leu Gln Asn Met Val Ser Ser Tyr Leu Val His His Gly Tyr
 255                 260                 265                 270

 tgt gcc aca gcc acg gct ttt gct cga atg act gaa acc ccg att cag      863
 Cys Ala Thr Ala Thr Ala Phe Ala Arg Met Thr Glu Thr Pro Ile Gln
                 275                 280                 285

 gaa gaa cag gcg tcc ata aag aac aga caa aag atc cag aag ctg gtg      911
 Glu Glu Gln Ala Ser Ile Lys Asn Arg Gln Lys Ile Gln Lys Leu Val
             290                 295                 300

 ctg gag ggc cgt gtg ggc gag gcc atc gag acc acc cag cgc ttc tac      959
 Leu Glu Gly Arg Val Gly Glu Ala Ile Glu Thr Thr Gln Arg Phe Tyr
         305                 310                 315

 cca ggg ctg ctg gag cac aac ccc aac ctc ctc ttc atg ctc aag tgc     1007
 Pro Gly Leu Leu Glu His Asn Pro Asn Leu Leu Phe Met Leu Lys Cys
     320                 325                 330

 cgg cag ttt gtg gag atg gtg aat ggg acg gac agt gag gtc cga agt     1055
 Arg Gln Phe Val Glu Met Val Asn Gly Thr Asp Ser Glu Val Arg Ser
 335                 340                 345                 350

 ttg agc tcc cga agc ccc aag tcc cag gac agc tac cct ggc tcc ccc     1103
 Leu Ser Ser Arg Ser Pro Lys Ser Gln Asp Ser Tyr Pro Gly Ser Pro
                 355                 360                 365

 agc ctc agt ccc cga cat ggc ccc agt agt tcc cac atg cac aac aca     1151
 Ser Leu Ser Pro Arg His Gly Pro Ser Ser Ser His Met His Asn Thr
             370                 375                 380

 gga gca gac agt ccc agc tgt agc aat ggc gtc gcg tcc acc aag agc     1199
 Gly Ala Asp Ser Pro Ser Cys Ser Asn Gly Val Ala Ser Thr Lys Ser
         385                 390                 395

 aaa cag aac cac agt aaa tac cct gca ccc agc tcc tca tcc tcg tcc     1247
 Lys Gln Asn His Ser Lys Tyr Pro Ala Pro Ser Ser Ser Ser Ser Ser
     400                 405                 410

 tcc tcc tcc tcc tcg tcc tct tcc cca tcc tcc gtc aat tac tcc gag     1295
 Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Ser Val Asn Tyr Ser Glu
 415                 420                 425                 430

 tcc aac tca aca gac tcc acc aag tcc cag cac cac agc agt acc agt     1343
 Ser Asn Ser Thr Asp Ser Thr Lys Ser Gln His His Ser Ser Thr Ser
                 435                 440                 445

 aac cag gag acc agc gac agt gag atg gag atg gag gca gag cac tac     1391
 Asn Gln Glu Thr Ser Asp Ser Glu Met Glu Met Glu Ala Glu His Tyr
             450                 455                 460

 ccc aac ggt gtg cta gga agc atg tcc aca cgc att gtt aat ggt gcc     1439
 Pro Asn Gly Val Leu Gly Ser Met Ser Thr Arg Ile Val Asn Gly Ala
         465                 470                 475

 tac aag cat gag gac ctg cag acg gat gag tcc agc atg gat gac agg     1487
 Tyr Lys His Glu Asp Leu Gln Thr Asp Glu Ser Ser Met Asp Asp Arg
     480                 485                 490

 cat cct cgg cgg cag ctc tgc ggg ggc aac cag gct gcc aca gaa agg     1535
 His Pro Arg Arg Gln Leu Cys Gly Gly Asn Gln Ala Ala Thr Glu Arg
 495                 500                 505                 510

 atc att ctg ttt ggc cgc gag ttg cag gca ttg agt gag cag ttg ggc     1583
 Ile Ile Leu Phe Gly Arg Glu Leu Gln Ala Leu Ser Glu Gln Leu Gly
                 515                 520                 525

 cgg gag tac ggc aag aat ttg gcc cac aca gag atg ctg cag gat gcc     1631
 Arg Glu Tyr Gly Lys Asn Leu Ala His Thr Glu Met Leu Gln Asp Ala
             530                 535                 540

 ttc agc ctg ctg gca tac tca gac ccc tgg agc tgc cca gtt ggc cag     1679
 Phe Ser Leu Leu Ala Tyr Ser Asp Pro Trp Ser Cys Pro Val Gly Gln
         545                 550                 555

 cag ctt gac ccc atc cag agg gaa cct gtg tgt gct gcc ctc aac agc     1727
 Gln Leu Asp Pro Ile Gln Arg Glu Pro Val Cys Ala Ala Leu Asn Ser
     560                 565                 570

 gcc att tta gag tcc cag aac ctg cca aag cag ccc cct ctg atg ctc     1775
 Ala Ile Leu Glu Ser Gln Asn Leu Pro Lys Gln Pro Pro Leu Met Leu
 575                 580                 585                 590

 gcc ctg ggc cag gca tct gag tgt ctc cgg ctc atg gcc cga gca ggc     1823
 Ala Leu Gly Gln Ala Ser Glu Cys Leu Arg Leu Met Ala Arg Ala Gly
                 595                 600                 605

 ctg ggt tct tgc tcc ttt gcc aga gtt gat gac tac ttg cac tag ctg     1871
 Leu Gly Ser Cys Ser Phe Ala Arg Val Asp Asp Tyr Leu His 
             610                 615                 620

 actgtgctgg ctggctctgg ctggccctcc actggcccca gggctggagc tgccctgccc   1931

 tccataggca actggtgcag ggactgggaa accatagaca gagtccactc ctcctgcctg   1991

 gcctttcccc ctctcccttt ccttccttcc ttcctttctc tgcccaccac cccgctcagt   2051

 ctctctctct ctccccttca cgtgcagcgg cctgtaacac agtattggct ggttactctc   2111

 atgtagcgcc ttctattttg aaaggggggt tttgttttga ggaggggttg gggtttttaa   2171

 atttttttct cctgactgag ccaccagtat ttatctctgg agagtttgtg ctgagctggt   2231

 ttctgctaat ttagtgatga agcctatcca agttggtgat agcttattat tttcataagt   2291

 aaaaaacaaa tgagattata tatatatata taaaaatata tatattaaaa aaaaaaaa     2349




      <210> 435
      <211> 2466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1985)

      <400> 435
 ccaag    atg gcg gca gcg acg gca gac ccg gga gct ggg aac ccg cag      47
          Met Ala Ala Ala Thr Ala Asp Pro Gly Ala Gly Asn Pro Gln
            1               5                  10

 cct ggg gac tcc tcc ggc ggg ggc gct ggg ggc ggg ctg ccg tcc cct       95
 Pro Gly Asp Ser Ser Gly Gly Gly Ala Gly Gly Gly Leu Pro Ser Pro
  15                  20                  25                  30

 ggg gag cag gag ctg agc cgg cgc ttg cag cgc ctg tat ccc gcg gtc      143
 Gly Glu Gln Glu Leu Ser Arg Arg Leu Gln Arg Leu Tyr Pro Ala Val
                  35                  40                  45

 aac cag caa gag act ccg ctg ccg cgc tcc tgg agc ccc aag gac aaa      191
 Asn Gln Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys
              50                  55                  60

 tac aac tac att ggt ctc tcc cag ggc aac ctc cgc gtc cac tac aaa      239
 Tyr Asn Tyr Ile Gly Leu Ser Gln Gly Asn Leu Arg Val His Tyr Lys
          65                  70                  75

 ggt cat ggc aaa aat cac aaa gat gcg gcc tca gtg cgt gcc acc cac      287
 Gly His Gly Lys Asn His Lys Asp Ala Ala Ser Val Arg Ala Thr His
      80                  85                  90

 ccc ata cct gct gcc tgt ggc att tat tac ttt gaa gtg aag att gtc      335
 Pro Ile Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val
  95                 100                 105                 110

 agc aaa gga aga gat ggt tac atg gga ata gga ctc tcg gct caa ggc      383
 Ser Lys Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly
                 115                 120                 125

 gtc aac atg aac aga ctt cct ggt tgg gac aaa cat tcc tat ggt tac      431
 Val Asn Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr
             130                 135                 140

 cat ggt gat gat ggg cat tcg ttc tgc tcc tcg ggg act ggc cag ccc      479
 His Gly Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro
         145                 150                 155

 tat ggt ccc aca ttc acc aca gga gac gtg atc ggc tgc tgt gtc aac      527
 Tyr Gly Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn
     160                 165                 170

 ctc atc aat ggc acc tgc ttc tac acc aag aat ggc cac agc ctt ggt      575
 Leu Ile Asn Gly Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly
 175                 180                 185                 190

 ata gcc ttc aca gac ctc ccg gga ctc act ctt gtc acc aag gct ggg      623
 Ile Ala Phe Thr Asp Leu Pro Gly Leu Thr Leu Val Thr Lys Ala Gly
                 195                 200                 205

 ttg cag tgg cag aat cac agc tta ctg cag cct caa ttt cct gga ctc      671
 Leu Gln Trp Gln Asn His Ser Leu Leu Gln Pro Gln Phe Pro Gly Leu
             210                 215                 220

 aag cca tct tcc cac ctc agc ctc ccg agt agc tgg gac cac agg aac      719
 Lys Pro Ser Ser His Leu Ser Leu Pro Ser Ser Trp Asp His Arg Asn
         225                 230                 235

 ctc tac ccc acc gta ggc ctg cag aca cct ggg gag att gtg gac gcc      767
 Leu Tyr Pro Thr Val Gly Leu Gln Thr Pro Gly Glu Ile Val Asp Ala
     240                 245                 250

 aac ttt ggg cag cag ccc ttc ctg ttt gac att gag gac tac atg cgg      815
 Asn Phe Gly Gln Gln Pro Phe Leu Phe Asp Ile Glu Asp Tyr Met Arg
 255                 260                 265                 270

 gag tgg cgt gcc aag gtc cag ggc acg gtc cac tgc ttc ccc atc agt      863
 Glu Trp Arg Ala Lys Val Gln Gly Thr Val His Cys Phe Pro Ile Ser
                 275                 280                 285

 gcc cgg ctt ggc gag tgg cag gca gtg ctg cag aac atg gtt tca tct      911
 Ala Arg Leu Gly Glu Trp Gln Ala Val Leu Gln Asn Met Val Ser Ser
             290                 295                 300

 tac ctc gtg cat cat ggg tat tgt gcc aca gcc acg gct ttt gct cga      959
 Tyr Leu Val His His Gly Tyr Cys Ala Thr Ala Thr Ala Phe Ala Arg
         305                 310                 315

 atg act gaa acc ccg att cag gaa gaa cag gcg tcc ata aag aac aga     1007
 Met Thr Glu Thr Pro Ile Gln Glu Glu Gln Ala Ser Ile Lys Asn Arg
     320                 325                 330

 caa aag atc cag aag ctg gtg ctg gag ggc cgt gtg ggc gag gcc atc     1055
 Gln Lys Ile Gln Lys Leu Val Leu Glu Gly Arg Val Gly Glu Ala Ile
 335                 340                 345                 350

 gag acc acc cag cgc ttc tac cca ggg ctg ctg gag cac aac ccc aac     1103
 Glu Thr Thr Gln Arg Phe Tyr Pro Gly Leu Leu Glu His Asn Pro Asn
                 355                 360                 365

 ctc ctc ttc atg ctc aag tgc cgg cag ttt gtg gag atg gtg aat ggg     1151
 Leu Leu Phe Met Leu Lys Cys Arg Gln Phe Val Glu Met Val Asn Gly
             370                 375                 380

 acg gac agt gag gtc cga agt ttg agc tcc cga agc ccc aag tcc cag     1199
 Thr Asp Ser Glu Val Arg Ser Leu Ser Ser Arg Ser Pro Lys Ser Gln
         385                 390                 395

 gac agc tac cct ggc tcc ccc agc ctc agt ccc cga cat ggc ccc agt     1247
 Asp Ser Tyr Pro Gly Ser Pro Ser Leu Ser Pro Arg His Gly Pro Ser
     400                 405                 410

 agt tcc cac atg cac aac aca gga gca gac agt ccc agc tgt agc aat     1295
 Ser Ser His Met His Asn Thr Gly Ala Asp Ser Pro Ser Cys Ser Asn
 415                 420                 425                 430

 ggc gtc gcg tcc acc aag agc aaa cag aac cac agt aaa tac cct gca     1343
 Gly Val Ala Ser Thr Lys Ser Lys Gln Asn His Ser Lys Tyr Pro Ala
                 435                 440                 445

 ccc agc tcc tca tcc tcg tcc tcc tcc tcc tcc tcg tcc tct tcc cca     1391
 Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro
             450                 455                 460

 tcc tcc gtc aat tac tcc gag tcc aac tca aca gac tcc acc aag tcc     1439
 Ser Ser Val Asn Tyr Ser Glu Ser Asn Ser Thr Asp Ser Thr Lys Ser
         465                 470                 475

 cag cac cac agc agt acc agt aac cag gag acc agc gac agt gag atg     1487
 Gln His His Ser Ser Thr Ser Asn Gln Glu Thr Ser Asp Ser Glu Met
     480                 485                 490

 gag atg gag gca gag cac tac ccc aac ggt gtg cta gga agc atg tcc     1535
 Glu Met Glu Ala Glu His Tyr Pro Asn Gly Val Leu Gly Ser Met Ser
 495                 500                 505                 510

 aca cgc att gtt aat ggt gcc tac aag cat gag gac ctg cag acg gat     1583
 Thr Arg Ile Val Asn Gly Ala Tyr Lys His Glu Asp Leu Gln Thr Asp
                 515                 520                 525

 gag tcc agc atg gat gac agg cat cct cgg cgg cag ctc tgc ggg ggc     1631
 Glu Ser Ser Met Asp Asp Arg His Pro Arg Arg Gln Leu Cys Gly Gly
             530                 535                 540

 aac cag gct gcc aca gaa agg atc att ctg ttt ggc cgc gag ttg cag     1679
 Asn Gln Ala Ala Thr Glu Arg Ile Ile Leu Phe Gly Arg Glu Leu Gln
         545                 550                 555

 gca ttg agt gag cag ttg ggc cgg gag tac ggc aag aat ttg gcc cac     1727
 Ala Leu Ser Glu Gln Leu Gly Arg Glu Tyr Gly Lys Asn Leu Ala His
     560                 565                 570

 aca gag atg ctg cag gat gcc ttc agc ctg ctg gca tac tca gac ccc     1775
 Thr Glu Met Leu Gln Asp Ala Phe Ser Leu Leu Ala Tyr Ser Asp Pro
 575                 580                 585                 590

 tgg agc tgc cca gtt ggc cag cag ctt gac ccc atc cag agg gaa cct     1823
 Trp Ser Cys Pro Val Gly Gln Gln Leu Asp Pro Ile Gln Arg Glu Pro
                 595                 600                 605

 gtg tgt gct gcc ctc aac agc gcc att tta gag tcc cag aac ctg cca     1871
 Val Cys Ala Ala Leu Asn Ser Ala Ile Leu Glu Ser Gln Asn Leu Pro
             610                 615                 620

 aag cag ccc cct ctg atg ctc gcc ctg ggc cag gca tct gag tgt ctc     1919
 Lys Gln Pro Pro Leu Met Leu Ala Leu Gly Gln Ala Ser Glu Cys Leu
         625                 630                 635

 cgg ctc atg gcc cga gca ggc ctg ggt tct tgc tcc ttt gcc aga gtt     1967
 Arg Leu Met Ala Arg Ala Gly Leu Gly Ser Cys Ser Phe Ala Arg Val
     640                 645                 650

 gat gac tac ttg cac tag ctgact gtgctggctg gctctggctg gccctccact     2021
 Asp Asp Tyr Leu His 
 655

 ggccccaggg ctggagctgc cctgccctcc ataggcaact ggtgcaggga ctgggaaacc   2081

 atagacagag tccactcctc ctgcctggcc tttccccctc tccctttcct tccttccttc   2141

 ctttctctgc ccaccacccc gctcagtctc tctctctctc cccttcacgt gcagcggcct   2201

 gtaacacagt attggctggt tactctcatg tagcgccttc tattttgaaa ggggggtttt   2261

 gttttgagga ggggttgggg tttttaaatt tttttctcct gactgagcca ccagtattta   2321

 tctctggaga gtttgtgctg agctggtttc tgctaattta gtgatgaagc ctatccaagt   2381

 tggtgatagc ttattatttt cataagtaaa aaacaaatga gattatatat atatatataa   2441

 aaatatatat attaaaaaaa aaaaa                                         2466




      <210> 436
      <211> 4986
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(4986)

      <400> 436
 atgagtcaga gagagcccca cccaagcagc agacaggcag ggggagctga gagcagcaaa     60

 cagcggcata acaaactatg gagatctcat tcagatagtg acctctcaga ccaccacgaa    120

 cccatctgca aacctgggct agaactcaac aagaaggata tcaccacctc agcagaccag    180

 attgctgagg tgaagacc  atg gag agt cac cca ccc ata cct cct gtc ttt     231
                      Met Glu Ser His Pro Pro Ile Pro Pro Val Phe
                        1               5                  10

 gtg gaa cat atg gtc cca caa gat gca aat cag aaa ggc ctg tgt acc      279
 Val Glu His Met Val Pro Gln Asp Ala Asn Gln Lys Gly Leu Cys Thr
              15                  20                  25

 aaa gaa aga atg atc tgc ttg gag ttt act tct agg gaa ttt cat gct      327
 Lys Glu Arg Met Ile Cys Leu Glu Phe Thr Ser Arg Glu Phe His Ala
          30                  35                  40

 gga cag att gag gat gaa tta aac tta aat gac atc aat gga tgc tca      375
 Gly Gln Ile Glu Asp Glu Leu Asn Leu Asn Asp Ile Asn Gly Cys Ser
      45                  50                  55

 tca ggg tgt tgt ctg aat gaa tca aaa ttt cct ctt gac aat tgc cat      423
 Ser Gly Cys Cys Leu Asn Glu Ser Lys Phe Pro Leu Asp Asn Cys His
  60                  65                  70                  75

 gca tcc aaa gcc tta att cag cct gga cat gtc cca gaa atg gcc aac      471
 Ala Ser Lys Ala Leu Ile Gln Pro Gly His Val Pro Glu Met Ala Asn
                  80                  85                  90

 aag ttt cca gac tta aca gtg gaa gat ttg gag aca gat gca ctg aaa      519
 Lys Phe Pro Asp Leu Thr Val Glu Asp Leu Glu Thr Asp Ala Leu Lys
              95                 100                 105

 gca gac atg aat gtc cac cta ctg cct atg gaa gaa ttg aca tct cca      567
 Ala Asp Met Asn Val His Leu Leu Pro Met Glu Glu Leu Thr Ser Pro
         110                 115                 120

 ctg aaa gac ccc ccc atg tcc cct gat cct gag tca cca agc ccc caa      615
 Leu Lys Asp Pro Pro Met Ser Pro Asp Pro Glu Ser Pro Ser Pro Gln
     125                 130                 135

 ccc agt tgc cag act gaa atc tca gat ttc agt aca gat cgc att gac      663
 Pro Ser Cys Gln Thr Glu Ile Ser Asp Phe Ser Thr Asp Arg Ile Asp
 140                 145                 150                 155

 ttt ttt agt gcc cta gag aag ttt gtg gag ctc tcc caa gaa acc cgg      711
 Phe Phe Ser Ala Leu Glu Lys Phe Val Glu Leu Ser Gln Glu Thr Arg
                 160                 165                 170

 tca cga tct ttt tcc cat tca agg atg gag gaa ctg ggt gga gga agg      759
 Ser Arg Ser Phe Ser His Ser Arg Met Glu Glu Leu Gly Gly Gly Arg
             175                 180                 185

 aat gag agc tgt cga ctg tca gtg gta gaa gta gcc cct tcc aaa gtg      807
 Asn Glu Ser Cys Arg Leu Ser Val Val Glu Val Ala Pro Ser Lys Val
         190                 195                 200

 aca gct gat gac cag aga agc agc tct ttg agt aat act ccc cat gca      855
 Thr Ala Asp Asp Gln Arg Ser Ser Ser Leu Ser Asn Thr Pro His Ala
     205                 210                 215

 tca gaa gaa tct tca atg gat gag gaa cag tca aag gca att tca gaa      903
 Ser Glu Glu Ser Ser Met Asp Glu Glu Gln Ser Lys Ala Ile Ser Glu
 220                 225                 230                 235

 ctg gtc agc cca gac atc ttc atg cag tct cac tcg gaa aat gca att      951
 Leu Val Ser Pro Asp Ile Phe Met Gln Ser His Ser Glu Asn Ala Ile
                 240                 245                 250

 tca gtc aaa gaa att gtc act gaa att gag tcc atc agt caa gga gtt      999
 Ser Val Lys Glu Ile Val Thr Glu Ile Glu Ser Ile Ser Gln Gly Val
             255                 260                 265

 ggg cag att caa ctg aaa gga gac atc tta ccc aac cca tgc cat aca     1047
 Gly Gln Ile Gln Leu Lys Gly Asp Ile Leu Pro Asn Pro Cys His Thr
         270                 275                 280

 cca aag aag aac agc atc cat gag ctg ctc ctt gag agg gcc cag act     1095
 Pro Lys Lys Asn Ser Ile His Glu Leu Leu Leu Glu Arg Ala Gln Thr
     285                 290                 295

 cca gag aac aaa cct gga cat atg gag caa gat gag gac tcc tgc aca     1143
 Pro Glu Asn Lys Pro Gly His Met Glu Gln Asp Glu Asp Ser Cys Thr
 300                 305                 310                 315

 gcc cag cct gaa cta gcc aaa gac tca ggg atg tgc aac cca gaa ggc     1191
 Ala Gln Pro Glu Leu Ala Lys Asp Ser Gly Met Cys Asn Pro Glu Gly
                 320                 325                 330

 tgc cta acc aca cac tca tct ata gca gac ttg gaa gaa ggg gaa cca     1239
 Cys Leu Thr Thr His Ser Ser Ile Ala Asp Leu Glu Glu Gly Glu Pro
             335                 340                 345

 gct gag ggg gaa caa gag ctc cag ggc tca ggg atg cac cca ggt gcc     1287
 Ala Glu Gly Glu Gln Glu Leu Gln Gly Ser Gly Met His Pro Gly Ala
         350                 355                 360

 aag tgg tac cct ggg tct gtg agg cga gcc acc ttg gag ttc gaa gag     1335
 Lys Trp Tyr Pro Gly Ser Val Arg Arg Ala Thr Leu Glu Phe Glu Glu
     365                 370                 375

 cgc tta cgg cag gag caa gag cat cat ggt gct gcc cca aca tgt acc     1383
 Arg Leu Arg Gln Glu Gln Glu His His Gly Ala Ala Pro Thr Cys Thr
 380                 385                 390                 395

 tca ttg tcc act cgt aag aat tca aag aat gat tct tct gtg gca gac     1431
 Ser Leu Ser Thr Arg Lys Asn Ser Lys Asn Asp Ser Ser Val Ala Asp
                 400                 405                 410

 cta gca cca aaa ggg aaa agt gat gaa gcc ccc cca gaa cat tca ttt     1479
 Leu Ala Pro Lys Gly Lys Ser Asp Glu Ala Pro Pro Glu His Ser Phe
             415                 420                 425

 gtc ctc aag gaa cca gaa atg agc aaa ggc aaa ggg aaa tac agt ggg     1527
 Val Leu Lys Glu Pro Glu Met Ser Lys Gly Lys Gly Lys Tyr Ser Gly
         430                 435                 440

 tct gag gct ggc tca ctg tcc cat tct gag cag aat gcc act gtt cca     1575
 Ser Glu Ala Gly Ser Leu Ser His Ser Glu Gln Asn Ala Thr Val Pro
     445                 450                 455

 gct ccc agg gtg ctg gag ttt gac cac ttg cca gat cct cag gag ggc     1623
 Ala Pro Arg Val Leu Glu Phe Asp His Leu Pro Asp Pro Gln Glu Gly
 460                 465                 470                 475

 cca ggg tca gat act gga aca cag cag gaa gga gtc ctg aag gat ctg     1671
 Pro Gly Ser Asp Thr Gly Thr Gln Gln Glu Gly Val Leu Lys Asp Leu
                 480                 485                 490

 agg act gtg att cca tac cag gag tct gaa aca caa gca gtc cct ctt     1719
 Arg Thr Val Ile Pro Tyr Gln Glu Ser Glu Thr Gln Ala Val Pro Leu
             495                 500                 505

 ccc ctt ccc aag agg gta gaa atc att gaa tat acc cac ata gtt aca     1767
 Pro Leu Pro Lys Arg Val Glu Ile Ile Glu Tyr Thr His Ile Val Thr
         510                 515                 520

 tca ccc aat cac act ggg cca ggg agt gaa ata gcc acc agt gag aag     1815
 Ser Pro Asn His Thr Gly Pro Gly Ser Glu Ile Ala Thr Ser Glu Lys
     525                 530                 535

 agc gga gag caa ggg ctg agg aaa gtg aac atg gaa aaa tct gtc act     1863
 Ser Gly Glu Gln Gly Leu Arg Lys Val Asn Met Glu Lys Ser Val Thr
 540                 545                 550                 555

 gtg ctc tgc aca ctg gat gaa aat cta aac agg act ctg gac ccc aac     1911
 Val Leu Cys Thr Leu Asp Glu Asn Leu Asn Arg Thr Leu Asp Pro Asn
                 560                 565                 570

 cag gtt tct ctg cac ccc caa gtg cta cct ctg cct cat tct tcc tcc     1959
 Gln Val Ser Leu His Pro Gln Val Leu Pro Leu Pro His Ser Ser Ser
             575                 580                 585

 cct gag cac aac aga ccc act gac cat cca acc tcc atc ctg agt agc     2007
 Pro Glu His Asn Arg Pro Thr Asp His Pro Thr Ser Ile Leu Ser Ser
         590                 595                 600

 cct gaa gac aga ggc agc agc ctg tcc aca gcc ctg gag aca gca gca     2055
 Pro Glu Asp Arg Gly Ser Ser Leu Ser Thr Ala Leu Glu Thr Ala Ala
     605                 610                 615

 cct ttt gtc agt cat aca acc cat tta ctg tct gcc agt ttg gat tac     2103
 Pro Phe Val Ser His Thr Thr His Leu Leu Ser Ala Ser Leu Asp Tyr
 620                 625                 630                 635

 ctg cat ccc cag act atg gtt cac ctg gag ggc ttc aca gag cag agc     2151
 Leu His Pro Gln Thr Met Val His Leu Glu Gly Phe Thr Glu Gln Ser
                 640                 645                 650

 agc act aca gat gag ccc tct gca gaa cag gtt agc tgg gaa gaa agt     2199
 Ser Thr Thr Asp Glu Pro Ser Ala Glu Gln Val Ser Trp Glu Glu Ser
             655                 660                 665

 cag gag agc cct ctc tcc agt ggc agt gag gtg cca tat aag gac tcc     2247
 Gln Glu Ser Pro Leu Ser Ser Gly Ser Glu Val Pro Tyr Lys Asp Ser
         670                 675                 680

 cag cta agt agc gca gac cta agt tta att agc aaa ctt ggt gac aac     2295
 Gln Leu Ser Ser Ala Asp Leu Ser Leu Ile Ser Lys Leu Gly Asp Asn
     685                 690                 695

 act ggg gag tta cag gag aaa atg gac cca ttg cct gta gcc tgt cga     2343
 Thr Gly Glu Leu Gln Glu Lys Met Asp Pro Leu Pro Val Ala Cys Arg
 700                 705                 710                 715

 ctc cca cat agc tct agt agt gaa aac ata aag agt ctc agc cac agc     2391
 Leu Pro His Ser Ser Ser Ser Glu Asn Ile Lys Ser Leu Ser His Ser
                 720                 725                 730

 ccc ggt gtg gtg aag gag cgt gct aaa gaa atc gag tct cga gtg gtt     2439
 Pro Gly Val Val Lys Glu Arg Ala Lys Glu Ile Glu Ser Arg Val Val
             735                 740                 745

 ttc cag gca ggg ctc acc aaa cca tcc caa atg agg cgc tca gct tct     2487
 Phe Gln Ala Gly Leu Thr Lys Pro Ser Gln Met Arg Arg Ser Ala Ser
         750                 755                 760

 ctc gcc aaa tta ggt tac ttg gac ctc tgt aaa gac tgc tta cca gag     2535
 Leu Ala Lys Leu Gly Tyr Leu Asp Leu Cys Lys Asp Cys Leu Pro Glu
     765                 770                 775

 agg gag cct gcc tcc tgt gaa tcc cct cat ctc aaa ctg ctt cag cct     2583
 Arg Glu Pro Ala Ser Cys Glu Ser Pro His Leu Lys Leu Leu Gln Pro
 780                 785                 790                 795

 ttc ctc aga aca gac tca ggc atg cac gcg atg gag gac caa gag tcc     2631
 Phe Leu Arg Thr Asp Ser Gly Met His Ala Met Glu Asp Gln Glu Ser
                 800                 805                 810

 cta gaa aac cca ggt gcc ccc cac aac cca gag ccc acc aag tct ttt     2679
 Leu Glu Asn Pro Gly Ala Pro His Asn Pro Glu Pro Thr Lys Ser Phe
             815                 820                 825

 gta gaa caa ctc aca aca aca gag tgt att gtg cag agc aag cca gtg     2727
 Val Glu Gln Leu Thr Thr Thr Glu Cys Ile Val Gln Ser Lys Pro Val
         830                 835                 840

 gag agg ccc ctt gtg cag tat gcc aaa gaa ttt ggt tct agt cag cag     2775
 Glu Arg Pro Leu Val Gln Tyr Ala Lys Glu Phe Gly Ser Ser Gln Gln
     845                 850                 855

 tat ttg ctc ccc agg gca gga ctt gaa ttg act agt tct gaa gga ggc     2823
 Tyr Leu Leu Pro Arg Ala Gly Leu Glu Leu Thr Ser Ser Glu Gly Gly
 860                 865                 870                 875

 ctt ccc gtg cta cag acc cag gga ctg caa cct gag gca tcg aat ggg     2871
 Leu Pro Val Leu Gln Thr Gln Gly Leu Gln Pro Glu Ala Ser Asn Gly
                 880                 885                 890

 cta aag gtc agc cag aag tca gag ggc tct cag cct tca tcc agc cgc     2919
 Leu Lys Val Ser Gln Lys Ser Glu Gly Ser Gln Pro Ser Ser Ser Arg
             895                 900                 905

 agc cct tta gag ttc ctg aag gag gca gag agc cgc agg atc ggc cag     2967
 Ser Pro Leu Glu Phe Leu Lys Glu Ala Glu Ser Arg Arg Ile Gly Gln
         910                 915                 920

 agt gcg gag ctg gac acc cgg gtc cca gat act aca gac acc cgg aga     3015
 Ser Ala Glu Leu Asp Thr Arg Val Pro Asp Thr Thr Asp Thr Arg Arg
     925                 930                 935

 ggt ggc tcc ttc gcc ctg aag cct tcc tcg gcc ccc tac gca ctc ggg     3063
 Gly Gly Ser Phe Ala Leu Lys Pro Ser Ser Ala Pro Tyr Ala Leu Gly
 940                 945                 950                 955

 ccc ctt ccg cag agg att cgc agc gtg agc gcc ccg cag ccc gct cag     3111
 Pro Leu Pro Gln Arg Ile Arg Ser Val Ser Ala Pro Gln Pro Ala Gln
                 960                 965                 970

 gac cag atg cga gtt cgg tat cct gtg gtg gct gca gtc ttg gcc cca     3159
 Asp Gln Met Arg Val Arg Tyr Pro Val Val Ala Ala Val Leu Ala Pro
             975                 980                 985

 tac ctg gct tta agc caa gat cca atg gtc aag tct tct gct tct gga     3207
 Tyr Leu Ala Leu Ser Gln Asp Pro Met Val Lys Ser Ser Ala Ser Gly
         990                 995                1000

 cag ggt gcc tct ggg agc tac aac cac gtc cgt gaa gag atg ctc atc     3255
 Gln Gly Ala Ser Gly Ser Tyr Asn His Val Arg Glu Glu Met Leu Ile
    1005                1010                1015

 aag gct ggc ggt gct atg agc aga cgt gtg gtt cgg caa agc aag ttc     3303
 Lys Ala Gly Gly Ala Met Ser Arg Arg Val Val Arg Gln Ser Lys Phe
1020                1025                1030                1035

 cgc cat gtg ttt ggg cag gca gca aag gcc gac cag gcc tac gag gac     3351
 Arg His Val Phe Gly Gln Ala Ala Lys Ala Asp Gln Ala Tyr Glu Asp
                1040                1045                1050

 atc cgt gtg tcc aag gtc aca tgg gac agc tcc ttc tgt gcc gtc aac     3399
 Ile Arg Val Ser Lys Val Thr Trp Asp Ser Ser Phe Cys Ala Val Asn
            1055                1060                1065

 ccc aaa ttc ctg gcc att att gtg gag gct gga ggc ggg ggt gcc ttc     3447
 Pro Lys Phe Leu Ala Ile Ile Val Glu Ala Gly Gly Gly Gly Ala Phe
        1070                1075                1080

 atc gtc ctg cct ctg gcc aag aca ggg cga gtg gat aag aac tac cca     3495
 Ile Val Leu Pro Leu Ala Lys Thr Gly Arg Val Asp Lys Asn Tyr Pro
    1085                1090                1095

 ctg gtc act ggg cac act gcc cct gtg ctg gat att gac tgg tgt cca     3543
 Leu Val Thr Gly His Thr Ala Pro Val Leu Asp Ile Asp Trp Cys Pro
1100                1105                1110                1115

 cac aat gac aac gtt atc gcc agt gcc tca gac gac acc acc atc atg     3591
 His Asn Asp Asn Val Ile Ala Ser Ala Ser Asp Asp Thr Thr Ile Met
                1120                1125                1130

 gtg tgg cag att cca gac tat acc ccc atg cgc aac att acg gaa cct     3639
 Val Trp Gln Ile Pro Asp Tyr Thr Pro Met Arg Asn Ile Thr Glu Pro
            1135                1140                1145

 atc atc aca ctt gag ggc cac tcc aag cgt gtg ggc atc ctc tcc tgg     3687
 Ile Ile Thr Leu Glu Gly His Ser Lys Arg Val Gly Ile Leu Ser Trp
        1150                1155                1160

 cac cct act gcc agg aat gtc ctg ctc agt gca ggt ggt gac aat gtg     3735
 His Pro Thr Ala Arg Asn Val Leu Leu Ser Ala Gly Gly Asp Asn Val
    1165                1170                1175

 atc atc atc tgg aat gtg ggc acc ggg gag gtg ctg ctg agc ctg gat     3783
 Ile Ile Ile Trp Asn Val Gly Thr Gly Glu Val Leu Leu Ser Leu Asp
1180                1185                1190                1195

 gat atg cac cca gac gtc atc cac agt gtg tgc tgg aac agc aac ggt     3831
 Asp Met His Pro Asp Val Ile His Ser Val Cys Trp Asn Ser Asn Gly
                1200                1205                1210

 agc ctg cta gcc acc acc tgc aag gac aag acc ttg cgc atc att gac     3879
 Ser Leu Leu Ala Thr Thr Cys Lys Asp Lys Thr Leu Arg Ile Ile Asp
            1215                1220                1225

 ccc aga aaa ggc caa gtg gtg gcg gag caa gcc cgg cct cac gag ggc     3927
 Pro Arg Lys Gly Gln Val Val Ala Glu Gln Ala Arg Pro His Glu Gly
        1230                1235                1240

 gcc cgc ccg ctg cgg gct gtc ttc acc gca gac ggg aag ctg ctc agc     3975
 Ala Arg Pro Leu Arg Ala Val Phe Thr Ala Asp Gly Lys Leu Leu Ser
    1245                1250                1255

 acc ggc ttc agc agg atg agt gag cgg caa ctc gcg ctc tgg gac ccg     4023
 Thr Gly Phe Ser Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro
1260                1265                1270                1275

 gag agg ttt gcg gcc cac gag ggg atg agg ccc atg cgg gcc gtc ttc     4071
 Glu Arg Phe Ala Ala His Glu Gly Met Arg Pro Met Arg Ala Val Phe
                1280                1285                1290

 acg cgc cag ggc cat atc ttc acc acg ggc ttc acc cgc atg agc cag     4119
 Thr Arg Gln Gly His Ile Phe Thr Thr Gly Phe Thr Arg Met Ser Gln
            1295                1300                1305

 cga gag ctg ggc ctg tgg gac ccg aac aac ttc gag gag cca gtg gca     4167
 Arg Glu Leu Gly Leu Trp Asp Pro Asn Asn Phe Glu Glu Pro Val Ala
        1310                1315                1320

 ctg cag gag atg gac aca agc aac ggg gtc cta ttg ccc ttt tac gat     4215
 Leu Gln Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro Phe Tyr Asp
    1325                1330                1335

 ccc gac tcc agc atc gtc tac ctg tgt ggc aag gtg ctc acg gcc ggg     4263
 Pro Asp Ser Ser Ile Val Tyr Leu Cys Gly Lys Val Leu Thr Ala Gly
1340                1345                1350                1355

 cag gga gaa cag ggc act gga tgg aga tgt gga ggg cct tgt ccg ggc     4311
 Gln Gly Glu Gln Gly Thr Gly Trp Arg Cys Gly Gly Pro Cys Pro Gly
                1360                1365                1370

 gcg ccc ctg aac cga ctg att ttg cag ggc gac agc agc att cgg tac     4359
 Ala Pro Leu Asn Arg Leu Ile Leu Gln Gly Asp Ser Ser Ile Arg Tyr
            1375                1380                1385

 ttt gag att acc gac gag ccg cct ttc gtg cac tac ctg aac acg ttc     4407
 Phe Glu Ile Thr Asp Glu Pro Pro Phe Val His Tyr Leu Asn Thr Phe
        1390                1395                1400

 agc agc aaa gag ccg cag cgg ggc atg ggt ttc atg ccc aaa agg gga     4455
 Ser Ser Lys Glu Pro Gln Arg Gly Met Gly Phe Met Pro Lys Arg Gly
    1405                1410                1415

 ctg gat gtc agc aag tgt gag atc gcc cgg ttc tac aag cta cac gaa     4503
 Leu Asp Val Ser Lys Cys Glu Ile Ala Arg Phe Tyr Lys Leu His Glu
1420                1425                1430                1435

 aga aag tgt gaa cct atc atc atg act gtg ccc cgc aag tca gac ctc     4551
 Arg Lys Cys Glu Pro Ile Ile Met Thr Val Pro Arg Lys Ser Asp Leu
                1440                1445                1450

 ttc cag gac gat ctg tac ccg gat acg cca ggc ccg gag ccg gcc cta     4599
 Phe Gln Asp Asp Leu Tyr Pro Asp Thr Pro Gly Pro Glu Pro Ala Leu
            1455                1460                1465

 gaa gcg gac gaa tgg cta tcc ggc cag gac gcc gaa ccc gtg ctc att     4647
 Glu Ala Asp Glu Trp Leu Ser Gly Gln Asp Ala Glu Pro Val Leu Ile
        1470                1475                1480

 tcg ctg agg gac ggc tat gtg ccc ccc aag cac cgc gag ctc cgg gtc     4695
 Ser Leu Arg Asp Gly Tyr Val Pro Pro Lys His Arg Glu Leu Arg Val
    1485                1490                1495

 acg aag cgc aac atc ctg gac gtg cgc ccg ccc tcc ggc ccc cgc cgc     4743
 Thr Lys Arg Asn Ile Leu Asp Val Arg Pro Pro Ser Gly Pro Arg Arg
1500                1505                1510                1515

 agc cag tcg gcc agc gac gcc ccc ttg tcg gta aga tcg gcc ctg ctg     4791
 Ser Gln Ser Ala Ser Asp Ala Pro Leu Ser Val Arg Ser Ala Leu Leu
                1520                1525                1530

 cac tct ggc cca atc tac atc tcc ccc aac cgc ccc tat acg aca cgg     4839
 His Ser Gly Pro Ile Tyr Ile Ser Pro Asn Arg Pro Tyr Thr Thr Arg
            1535                1540                1545

 cct ctc tgt cct ccg ccc cag cag cag cac acc ctg gag acg ctg ctg     4887
 Pro Leu Cys Pro Pro Pro Gln Gln Gln His Thr Leu Glu Thr Leu Leu
        1550                1555                1560

 gaa gag atc aag gcc ctc cgc gag cgg gtg cag gcc cag gag cag cgc     4935
 Glu Glu Ile Lys Ala Leu Arg Glu Arg Val Gln Ala Gln Glu Gln Arg
    1565                1570                1575

 atc acg gct ctg gag aac atg ctg tgc gag ctg gtg gac ggc acg gac     4983
 Ile Thr Ala Leu Glu Asn Met Leu Cys Glu Leu Val Asp Gly Thr Asp
1580                1585                1590                1595

 tag                                                                 4986
 






      <210> 437
      <211> 1889
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (215)..(1558)

      <220>
      <221> misc_feature
      <222> (1)...(1889)
      <223> n = a,t,c or g

      <400> 437
 ctatcccatg ggacttcctc catccccttg attctgggga agtactgtga ccgctttgac     60

 cattttgata ttgcaaaatt gatgctgtac ccttaaccaa cctgagctct catttcctgc    120

 ctcttggaag ttagctgctg tgtataattt cctgagctca ctatgcactg aaaagccgcg    180

 gaggcgcgcc cgaactgtcg cggccgccgc caac    atg gcc gag acc agc gag     232
                                          Met Ala Glu Thr Ser Glu
                                            1               5

 gag gtg gcg gtg ctg gtg cag cgg gtt gtg aag gac atc act aac gcc      280
 Glu Val Ala Val Leu Val Gln Arg Val Val Lys Asp Ile Thr Asn Ala
              10                  15                  20

 ttc agg agg aac cca cac ata gat gaa att ggc ctg atc cca tgt cct      328
 Phe Arg Arg Asn Pro His Ile Asp Glu Ile Gly Leu Ile Pro Cys Pro
          25                  30                  35

 gaa gct agg tat aac cgg agt ccc ata gtc ctg gtt gaa aac aaa ctg      376
 Glu Ala Arg Tyr Asn Arg Ser Pro Ile Val Leu Val Glu Asn Lys Leu
      40                  45                  50

 ggt gtg gag agc tgg tgt gtc aag ttc ctt tta cca tat gtc cac aac      424
 Gly Val Glu Ser Trp Cys Val Lys Phe Leu Leu Pro Tyr Val His Asn
  55                  60                  65                  70

 aag ctc ctt ttg tac aga aca aga aag caa tgg ctg aac aga gat gaa      472
 Lys Leu Leu Leu Tyr Arg Thr Arg Lys Gln Trp Leu Asn Arg Asp Glu
                  75                  80                  85

 ttg ata gat gtc aca tgt acc ctg ctg ctt cta aac cca gac ttt acc      520
 Leu Ile Asp Val Thr Cys Thr Leu Leu Leu Leu Asn Pro Asp Phe Thr
              90                  95                 100

 act gca tgg aac gtg agg tat gtc att ttc att agt gat atg ata aag      568
 Thr Ala Trp Asn Val Arg Tyr Val Ile Phe Ile Ser Asp Met Ile Lys
         105                 110                 115

 ttt gtc caa att tct gaa gac atg aaa gag ctg atc ctc tct ggc act      616
 Phe Val Gln Ile Ser Glu Asp Met Lys Glu Leu Ile Leu Ser Gly Thr
     120                 125                 130

 tta aat cca att aag gat tta cat ctg gga aaa ctc gcc tta acc aag      664
 Leu Asn Pro Ile Lys Asp Leu His Leu Gly Lys Leu Ala Leu Thr Lys
 135                 140                 145                 150

 ttt cca aag agt cca gaa aca tgg att cac agg cga tgg gtg cta caa      712
 Phe Pro Lys Ser Pro Glu Thr Trp Ile His Arg Arg Trp Val Leu Gln
                 155                 160                 165

 cag cta att cag gaa acc tcc ttg cct tcc ttt gtg acc aaa gga aac      760
 Gln Leu Ile Gln Glu Thr Ser Leu Pro Ser Phe Val Thr Lys Gly Asn
             170                 175                 180

 ttg gga aca att ccc aca gaa agg gca cag cga ctc ata caa gaa gag      808
 Leu Gly Thr Ile Pro Thr Glu Arg Ala Gln Arg Leu Ile Gln Glu Glu
         185                 190                 195

 atg gag gtc tgt ggt gaa gca gca ggg aga tac cca agc aac tat aat      856
 Met Glu Val Cys Gly Glu Ala Ala Gly Arg Tyr Pro Ser Asn Tyr Asn
     200                 205                 210

 gct tgg tcc cat cgc atc tgg gtt tta cag cac ttg gcc aag cta gat      904
 Ala Trp Ser His Arg Ile Trp Val Leu Gln His Leu Ala Lys Leu Asp
 215                 220                 225                 230

 gtc aag att ctt ctt gat gaa cta tct tct act aaa cat tgg gca tct      952
 Val Lys Ile Leu Leu Asp Glu Leu Ser Ser Thr Lys His Trp Ala Ser
                 235                 240                 245

 atg cac gtt tca gac cac agt gga ttt cac tac cgc cag ttt ttg ctt     1000
 Met His Val Ser Asp His Ser Gly Phe His Tyr Arg Gln Phe Leu Leu
             250                 255                 260

 aag tct ttg att agc caa act gtg ata gac agt tct gtg atg gag caa     1048
 Lys Ser Leu Ile Ser Gln Thr Val Ile Asp Ser Ser Val Met Glu Gln
         265                 270                 275

 aat cct ttg aga agt gag cca gcc cta gtt cct cca aaa gat gaa gaa     1096
 Asn Pro Leu Arg Ser Glu Pro Ala Leu Val Pro Pro Lys Asp Glu Glu
     280                 285                 290

 gca gca gtt tca aca gaa gaa cca agg att aat ctt ccc cat ctt cta     1144
 Ala Ala Val Ser Thr Glu Glu Pro Arg Ile Asn Leu Pro His Leu Leu
 295                 300                 305                 310

 gaa gaa gaa gtt gaa ttc agc act gat ctt att gat tcc tac cca gga     1192
 Glu Glu Glu Val Glu Phe Ser Thr Asp Leu Ile Asp Ser Tyr Pro Gly
                 315                 320                 325

 cat gaa acc ctt tgg tgt cat agg cgg cat att ttc tac ctt cag cat     1240
 His Glu Thr Leu Trp Cys His Arg Arg His Ile Phe Tyr Leu Gln His
             330                 335                 340

 cac tta aat ggt agg ttt cct cac agc atg acc cag ttg tca cct gca     1288
 His Leu Asn Gly Arg Phe Pro His Ser Met Thr Gln Leu Ser Pro Ala
         345                 350                 355

 gac agc cct ggg ggg act ttg agt gac ttg cac ctt atc cca gca ggc     1336
 Asp Ser Pro Gly Gly Thr Leu Ser Asp Leu His Leu Ile Pro Ala Gly
     360                 365                 370

 tcc cag ctg tct caa gca atg gaa gta gat gga ctg aat gac tct agc     1384
 Ser Gln Leu Ser Gln Ala Met Glu Val Asp Gly Leu Asn Asp Ser Ser
 375                 380                 385                 390

 aag caa ggc tat tcc cag gaa acc aaa cgc ctg aag cgg acg cca gtt     1432
 Lys Gln Gly Tyr Ser Gln Glu Thr Lys Arg Leu Lys Arg Thr Pro Val
                 395                 400                 405

 cca gac tcc cta ggc cta gaa atg gag cac agg ttc att gat caa gta     1480
 Pro Asp Ser Leu Gly Leu Glu Met Glu His Arg Phe Ile Asp Gln Val
             410                 415                 420

 ttg tcc acc tgt cgg aac gtg gag caa gcc agg ttt gcc agt gca tac     1528
 Leu Ser Thr Cys Arg Asn Val Glu Gln Ala Arg Phe Ala Ser Ala Tyr
         425                 430                 435

 agg aaa tgg ctg gtt act ttg agt caa tga a agaggtgaat tagtcctaca     1579
 Arg Lys Trp Leu Val Thr Leu Ser Gln 
     440                 445

 aggttcccct tttagtgcaa tattgctttc ttttattatt tacatagttg catgaactgt   1639

 ttactattat tggctaacca tatgttcttc gtctttaggt tgaaagtcca tagtaaatct   1699

 ttcattttat ttattttgtt aataactggc attcctgtgg ggataaaata atcgtatagt   1759

 tccttcctgc tgaacagcga gtcttaaatt ttctgtttaa cttctcaccc tttgtatttc   1819

 tatatgtggg gcttctcatt tggttttcnt gattggttca cacacacaca cctccacata   1879

 aatacacaca                                                          1889




      <210> 438
      <211> 1793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (215)..(1504)

      <400> 438
 ctatcccatg ggacttcctc catccccttg attctgggga agtactgtga ccgctttgac     60

 cattttgata ttgcaaaatt gatgctgtac ccttaaccaa cctgagctct catttcctgc    120

 ctcttggaag ttagctgctg tgtataattt cctgagctca ctatgcactg aaaagccgcg    180

 gaggcgcgcc cgaactgtcg cggccgccgc caac    atg gcc gag acc agc gag     232
                                          Met Ala Glu Thr Ser Glu
                                            1               5

 gag gtg gcg gtg ctg gtg cag cgg gtt gtg aag gac atc act aac gcc      280
 Glu Val Ala Val Leu Val Gln Arg Val Val Lys Asp Ile Thr Asn Ala
              10                  15                  20

 ttc agg agg aac cca cac ata gat gaa att ggc ctg atc cca tgt cct      328
 Phe Arg Arg Asn Pro His Ile Asp Glu Ile Gly Leu Ile Pro Cys Pro
          25                  30                  35

 gaa gct agg tat aac cgg agt ccc ata gtc ctg gtt gaa aac aaa ctg      376
 Glu Ala Arg Tyr Asn Arg Ser Pro Ile Val Leu Val Glu Asn Lys Leu
      40                  45                  50

 ggt gtg gag agc tgg tgt gtc aag ttc ctt tta cca tat gtc cac aac      424
 Gly Val Glu Ser Trp Cys Val Lys Phe Leu Leu Pro Tyr Val His Asn
  55                  60                  65                  70

 aag ctc ctt ttg tac aga aca aga aag caa tgg ctg aac aga gat gaa      472
 Lys Leu Leu Leu Tyr Arg Thr Arg Lys Gln Trp Leu Asn Arg Asp Glu
                  75                  80                  85

 ttg ata gat gtc aca tgt acc ctg ctg ctt cta aac cca gac ttt acc      520
 Leu Ile Asp Val Thr Cys Thr Leu Leu Leu Leu Asn Pro Asp Phe Thr
              90                  95                 100

 act gca tgg aac gtg agg aaa gag ctg atc ctc tct ggc act tta aat      568
 Thr Ala Trp Asn Val Arg Lys Glu Leu Ile Leu Ser Gly Thr Leu Asn
         105                 110                 115

 cca att aag gat tta cat ctg gga aaa ctc gcc tta acc aag ttt cca      616
 Pro Ile Lys Asp Leu His Leu Gly Lys Leu Ala Leu Thr Lys Phe Pro
     120                 125                 130

 aag agt cca gaa aca tgg att cac agg cga tgg gtg cta caa cag cta      664
 Lys Ser Pro Glu Thr Trp Ile His Arg Arg Trp Val Leu Gln Gln Leu
 135                 140                 145                 150

 att cag gaa acc tcc ttg cct tcc ttt gtg acc aaa gga aac ttg gga      712
 Ile Gln Glu Thr Ser Leu Pro Ser Phe Val Thr Lys Gly Asn Leu Gly
                 155                 160                 165

 aca att ccc aca gaa agg gca cag cga ctc ata caa gaa gag atg gag      760
 Thr Ile Pro Thr Glu Arg Ala Gln Arg Leu Ile Gln Glu Glu Met Glu
             170                 175                 180

 gtc tgt ggt gaa gca gca ggg aga tac cca agc aac tat aat gct tgg      808
 Val Cys Gly Glu Ala Ala Gly Arg Tyr Pro Ser Asn Tyr Asn Ala Trp
         185                 190                 195

 tcc cat cgc atc tgg gtt tta cag cac ttg gcc aag cta gat gtc aag      856
 Ser His Arg Ile Trp Val Leu Gln His Leu Ala Lys Leu Asp Val Lys
     200                 205                 210

 att ctt ctt gat gaa cta tct tct act aaa cat tgg gca tct atg cac      904
 Ile Leu Leu Asp Glu Leu Ser Ser Thr Lys His Trp Ala Ser Met His
 215                 220                 225                 230

 gtt tca gac cac agt gga ttt cac tac cgc cag ttt ttg ctt aag tct      952
 Val Ser Asp His Ser Gly Phe His Tyr Arg Gln Phe Leu Leu Lys Ser
                 235                 240                 245

 ttg att agc caa act gtg ata gac agt tct gtg atg gag caa aat cct     1000
 Leu Ile Ser Gln Thr Val Ile Asp Ser Ser Val Met Glu Gln Asn Pro
             250                 255                 260

 ttg aga agt gag cca gcc cta gtt cct cca aaa gat gaa gaa gca gca     1048
 Leu Arg Ser Glu Pro Ala Leu Val Pro Pro Lys Asp Glu Glu Ala Ala
         265                 270                 275

 gtt tca aca gaa gaa cca agg att aat ctt ccc cat ctt cta gaa gaa     1096
 Val Ser Thr Glu Glu Pro Arg Ile Asn Leu Pro His Leu Leu Glu Glu
     280                 285                 290

 gaa gtt gaa ttc agc act gat ctt att gat tcc tac cca gga cat gaa     1144
 Glu Val Glu Phe Ser Thr Asp Leu Ile Asp Ser Tyr Pro Gly His Glu
 295                 300                 305                 310

 acc ctt tgg tgt cat agg cgg cat att ttc tac ctt cag cat cac tta     1192
 Thr Leu Trp Cys His Arg Arg His Ile Phe Tyr Leu Gln His His Leu
                 315                 320                 325

 aat ggt agg ttt cct cac agc atg acc cag ttg tca cct gca gac agc     1240
 Asn Gly Arg Phe Pro His Ser Met Thr Gln Leu Ser Pro Ala Asp Ser
             330                 335                 340

 cct ggg ggg act ttg agt gac ttg cac ctt atc cca gca ggc tcc cag     1288
 Pro Gly Gly Thr Leu Ser Asp Leu His Leu Ile Pro Ala Gly Ser Gln
         345                 350                 355

 ctg tct caa gca atg gaa gta gat gga ctg aat gac tct agc aag caa     1336
 Leu Ser Gln Ala Met Glu Val Asp Gly Leu Asn Asp Ser Ser Lys Gln
     360                 365                 370

 ggc tat tcc cag gaa acc aaa cgc ctg aag cgg acg cca gtt cca gac     1384
 Gly Tyr Ser Gln Glu Thr Lys Arg Leu Lys Arg Thr Pro Val Pro Asp
 375                 380                 385                 390

 tcc cta ggc cta gaa atg gag cac agg ttc att gat caa gta ttg tcc     1432
 Ser Leu Gly Leu Glu Met Glu His Arg Phe Ile Asp Gln Val Leu Ser
                 395                 400                 405

 acc tgt cgg aac gtg gag caa gcc agg ttt gcc agt gca tac agg aaa     1480
 Thr Cys Arg Asn Val Glu Gln Ala Arg Phe Ala Ser Ala Tyr Arg Lys
             410                 415                 420

 tgg ctg gtt act ttg agt caa tga aagaggtgaa ttagtcctac aaggttcccc    1534
 Trp Leu Val Thr Leu Ser Gln 
         425

 ttttagtgca atattgcttt cttttattat ttacatagtt gcatgaactg tttactatta   1594

 ttggctaacc atatgttctt cgtctttagg ttgaaagtcc atagtaaatc tttcatttta   1654

 tttattttgt taataactgg cattcctgtg gggataaaat aatcgtatag ttccttcctg   1714

 ctgaacagcg agtcttaaat tttctgttta acttctcacc ctttgtattt ctatatgtgg   1774

 ggcttctcat ttggttttc                                                1793




      <210> 439
      <211> 824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(273)

      <400> 439
 gattgccctt cacagaaaaa cttgctgacc ctagtatagt acaggatatg ttggaaagaa     60

 aagaataaat ctagaactgt gaggaatgtt tccagaaaaa caaaggtggt gtcagtgtag    120

 tcattgatat gaaaggagag ccgtgggaac tgcattctag cacctaaagg a atg ggt     177
                                                          Met Gly
                                                            1

 gag gag cat gag caa cag atg aat aag tat ggg gaa gag gcc cca gaa      225
 Glu Glu His Glu Gln Gln Met Asn Lys Tyr Gly Glu Glu Ala Pro Glu
           5                  10                  15

 ttt agc aat ggc tgt tct gta aca ggg ctc cca cag ttc aca ggt tag      273
 Phe Ser Asn Gly Cys Ser Val Thr Gly Leu Pro Gln Phe Thr Gly 
      20                  25                  30

 caatgtgtgt gagtccgtgt ttaatttgcc ctgttaaatt ctaacttcta ggttttgatc    333

 tttcattcta gactactgac ataattttga gttccaattc tgtttgctga attagctgtc    393

 tttccatttg gtctttaaaa atagactttc aggctatgta ataagtagtt ttttacttac    453

 tgcacagtac tttattgctt tgaatgtcag gtgtggcaac agtaaacatt tgtgtgtgtg    513

 atatgtgttt gagggccgtt ctactgagtc atttctaatt taccaggaac atgtttgctg    573

 ccaattatat gttgagactt catttcagac gaatttttta caaattaaac tttctcttct    633

 cttgaaactt cagacatgta ggtatgaagt ttcaagagaa gagaaagttt agacatgtag    693

 gtatgaaaat atcaaattaa taacaattgt tttctgtctt aaaagaattc agagatcatt    753

 gggaaccttt taaaacttga tggagatgtt agcctaatga ttttgtggga taaagtgaaa    813

 ggtcttactt c                                                         824




      <210> 440
      <211> 462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(293)

      <400> 440
 aggtcgagga acaaggtcgt gaaaaaaaaa ggtcttggtg aggtgccgcc atttcatctg     60

 tcctcattct ctgcgccttt cgcagagctt ccagcagcgg t    atg ttg ggc cag     113
                                                  Met Leu Gly Gln
                                                    1

 agc atc cgg agg gtc aca acc tct gtg gtc cgt agg agc cac tat gag      161
 Ser Ile Arg Arg Val Thr Thr Ser Val Val Arg Arg Ser His Tyr Glu
   5                  10                  15                  20

 gag ggc cct ggg aag aat ttg cca ttt tca gtg gaa aac aag tgg tcg      209
 Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu Asn Lys Trp Ser
                  25                  30                  35

 tta cta gct aag atg tgt ttg tac ttt gga tct gca tgt gct aca ccc      257
 Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala Cys Ala Thr Pro
              40                  45                  50

 ttc cgt gta gta aga cac caa ctg ctt gaa aca taa ggat gttccagctc      307
 Phe Arg Val Val Arg His Gln Leu Leu Glu Thr 
          55                  60

 ctccagtcaa cagatatgaa gcgcatttta agaggttcgg cctctgggac tggatcaaac    367

 tggaactcat atgccatact agataggttt gtcggtgacc tgctgacgtg aagaaaaaaa    427

 aaagtcggac ggccgccaat taattaatag taagt                               462




      <210> 441
      <211> 1727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (273)..(1727)

      <400> 441
 tgttgagtcc cttgggtacc ggcccggaat tcccgggtcg acgatttcgt aggaatctca     60

 gcctggggag tcccagagct ggggtccaca gcctcagggg atggagggtc tgagggctat    120

 tggggcctgc cctggaccca gttccctgag tccccacttc acacccccag ggcctccccg    180

 ctctttccac ctccaagctc ctgctaggct cacgcctgtc tattgcaggg gcccagggcc    240

 ggaaccagga ggagcgcctg ctcgcagacc tg  atg caa aac tac gac ccc aac     293
                                      Met Gln Asn Tyr Asp Pro Asn
                                        1               5

 ctg cgg ccc gcg gaa cga gac tcg gat gtg gtc aat gtc agc ctg aag      341
 Leu Arg Pro Ala Glu Arg Asp Ser Asp Val Val Asn Val Ser Leu Lys
          10                  15                  20

 cta acc ctc acc aac ctc atc tcc ctg aac gag cga gag gaa gcc ctc      389
 Leu Thr Leu Thr Asn Leu Ile Ser Leu Asn Glu Arg Glu Glu Ala Leu
      25                  30                  35

 acc acc aat gtc tgg ata gag atg cag tgg tgc gac tat cgc ctg cgc      437
 Thr Thr Asn Val Trp Ile Glu Met Gln Trp Cys Asp Tyr Arg Leu Arg
  40                  45                  50                  55

 tgg gat ccg cga gac tac gaa ggc ctg tgg gtg ctg agg gtg ccg tcc      485
 Trp Asp Pro Arg Asp Tyr Glu Gly Leu Trp Val Leu Arg Val Pro Ser
                  60                  65                  70

 acc atg gtg tgg cgg ccg gat atc gtg ctg gag aac aac gtg gac ggt      533
 Thr Met Val Trp Arg Pro Asp Ile Val Leu Glu Asn Asn Val Asp Gly
              75                  80                  85

 gtc ttc gag gtg gcc ctc tac tgc aat gtg ctc gtg tcc cct gac ggc      581
 Val Phe Glu Val Ala Leu Tyr Cys Asn Val Leu Val Ser Pro Asp Gly
          90                  95                 100

 tgt atc tac tgg ctg ccg cct gcc atc ttc cgt tcc gcc tgc tct atc      629
 Cys Ile Tyr Trp Leu Pro Pro Ala Ile Phe Arg Ser Ala Cys Ser Ile
     105                 110                 115

 tca gtc acc tac ttc ccc ttc gac tgg cag aac tgc tcc ctt atc ttc      677
 Ser Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Ser Leu Ile Phe
 120                 125                 130                 135

 cag tcc cag act tac agc acc aat gag att gat ctg cag ctg agt cag      725
 Gln Ser Gln Thr Tyr Ser Thr Asn Glu Ile Asp Leu Gln Leu Ser Gln
                 140                 145                 150

 gaa gat ggc cag acc atc gag tgg att ttc att gac cct gag gcc ttc      773
 Glu Asp Gly Gln Thr Ile Glu Trp Ile Phe Ile Asp Pro Glu Ala Phe
             155                 160                 165

 aca gag aat ggg gag tgg gcc atc cag cac cga cca gcc aag atg ctc      821
 Thr Glu Asn Gly Glu Trp Ala Ile Gln His Arg Pro Ala Lys Met Leu
         170                 175                 180

 ctg gac cca gcg gcg cca gcc cag gaa gca ggc cac cag aag gtg gtg      869
 Leu Asp Pro Ala Ala Pro Ala Gln Glu Ala Gly His Gln Lys Val Val
     185                 190                 195

 ttc tac ctg ctc atc cag cgc aag ccc ctc ttc tac gtc atc aac atc      917
 Phe Tyr Leu Leu Ile Gln Arg Lys Pro Leu Phe Tyr Val Ile Asn Ile
 200                 205                 210                 215

 atc gcc ccc tgt gtg ctc atc tcc tct gtc gcc atc ctc atc cac ttc      965
 Ile Ala Pro Cys Val Leu Ile Ser Ser Val Ala Ile Leu Ile His Phe
                 220                 225                 230

 ctt cct gcc aag gct ggg ggc cag aag tgt acc gtc gcc atc aac gtg     1013
 Leu Pro Ala Lys Ala Gly Gly Gln Lys Cys Thr Val Ala Ile Asn Val
             235                 240                 245

 ctc ctg gcc cag act gtc ttc ctc ttc ctt gtg gcc aag aag gtg cct     1061
 Leu Leu Ala Gln Thr Val Phe Leu Phe Leu Val Ala Lys Lys Val Pro
         250                 255                 260

 gaa acc tcc cag gcg gtg cca ctc atc agc aag tac ctg acc ttc ctc     1109
 Glu Thr Ser Gln Ala Val Pro Leu Ile Ser Lys Tyr Leu Thr Phe Leu
     265                 270                 275

 ctg gtg gtg acc atc ctc att gtc gtg aat gct gtg gtt gtg ctc aat     1157
 Leu Val Val Thr Ile Leu Ile Val Val Asn Ala Val Val Val Leu Asn
 280                 285                 290                 295

 gtc tcc ttg cgg tct cca cac aca cac tcc atg gcc cga ggg gtc cgc     1205
 Val Ser Leu Arg Ser Pro His Thr His Ser Met Ala Arg Gly Val Arg
                 300                 305                 310

 aag gtg ttc ctg agg ctc ttg ccc cag ctg ctg agg atg cac gtt cgc     1253
 Lys Val Phe Leu Arg Leu Leu Pro Gln Leu Leu Arg Met His Val Arg
             315                 320                 325

 ccg ctg gcc ccg gca gct gtg cag gac acc cag tcc cgg cta cag aat     1301
 Pro Leu Ala Pro Ala Ala Val Gln Asp Thr Gln Ser Arg Leu Gln Asn
         330                 335                 340

 ggc tcc tcg gga tgg tcg atc aca act ggg gag gag gtg gcc ctc tgc     1349
 Gly Ser Ser Gly Trp Ser Ile Thr Thr Gly Glu Glu Val Ala Leu Cys
     345                 350                 355

 ctg cct cgc agt gaa ctc ctc ttc cag cag tgg cag cgg caa ggg ctg     1397
 Leu Pro Arg Ser Glu Leu Leu Phe Gln Gln Trp Gln Arg Gln Gly Leu
 360                 365                 370                 375

 gtg gcg gca gcg ctg gag aag cta gag aaa ggc ccg gag tta ggg ctg     1445
 Val Ala Ala Ala Leu Glu Lys Leu Glu Lys Gly Pro Glu Leu Gly Leu
                 380                 385                 390

 agc cag ttc tgt ggc agc ctg aag cag gct gcc cca gcc atc cag gcc     1493
 Ser Gln Phe Cys Gly Ser Leu Lys Gln Ala Ala Pro Ala Ile Gln Ala
             395                 400                 405

 tgt gtg gaa gcc tgc aac ctc att gcc tgt gcc cgg cac cag cag agt     1541
 Cys Val Glu Ala Cys Asn Leu Ile Ala Cys Ala Arg His Gln Gln Ser
         410                 415                 420

 cac ttt gac aat ggg aat gag gag tgg ttc ctg gtg ggc cga gtg ctg     1589
 His Phe Asp Asn Gly Asn Glu Glu Trp Phe Leu Val Gly Arg Val Leu
     425                 430                 435

 gac cgc gtc tgc ttc ctg gcc atg ctc tcg ctc ttc atc tgt ggc aca     1637
 Asp Arg Val Cys Phe Leu Ala Met Leu Ser Leu Phe Ile Cys Gly Thr
 440                 445                 450                 455

 gct ggc atc ttc ctc atg gcc cac tac aac cgg gtg ccg gcc ctg cca     1685
 Ala Gly Ile Phe Leu Met Ala His Tyr Asn Arg Val Pro Ala Leu Pro
                 460                 465                 470

 ttc cct gga gat cca cgc ccc tac ctg ccc tca cca gac tga             1727
 Phe Pro Gly Asp Pro Arg Pro Tyr Leu Pro Ser Pro Asp 
             475                 480





      <210> 442
      <211> 2320
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(660)

      <400> 442
 ttcggaattc ccgggtcgac gatttcgtgg agttcgactt ttgacgggag ttgagaagta     60

 taaagactga aaactaaagc ctgcaaagac ctctgaagga aaacctgtcc cgggctctgt    120

 cacttcacac cc    atg gct aac cct gga ggt ggt gct gtt tgc aac ggg     168
                  Met Ala Asn Pro Gly Gly Gly Ala Val Cys Asn Gly
                    1               5                  10

 aaa ctt cac aat cac aag aaa cag agc aat ggc tca caa agc aga aac      216
 Lys Leu His Asn His Lys Lys Gln Ser Asn Gly Ser Gln Ser Arg Asn
          15                  20                  25

 tgc aca aag aat gga ata gtg aag gaa gcc cag caa aat ggg aag cca      264
 Cys Thr Lys Asn Gly Ile Val Lys Glu Ala Gln Gln Asn Gly Lys Pro
      30                  35                  40

 cat ttt tat gat aag ctc att gtt gaa tcg ttt gag gaa gca ccc ctt      312
 His Phe Tyr Asp Lys Leu Ile Val Glu Ser Phe Glu Glu Ala Pro Leu
  45                  50                  55                  60

 cat gtt atg gtt ttc act tac atg gga tat gga att gga acc ctg ttt      360
 His Val Met Val Phe Thr Tyr Met Gly Tyr Gly Ile Gly Thr Leu Phe
                  65                  70                  75

 ggc tat ctc aga gac ttt tta aga aac tgg gga ata gaa aaa tgc aac      408
 Gly Tyr Leu Arg Asp Phe Leu Arg Asn Trp Gly Ile Glu Lys Cys Asn
              80                  85                  90

 gca gct gtg gaa cga aaa gaa caa aaa gta cgt atg cgc acc tcc ctg      456
 Ala Ala Val Glu Arg Lys Glu Gln Lys Val Arg Met Arg Thr Ser Leu
          95                 100                 105

 gat ctt tgt caa tgc cta ctc ctc tct aaa gtg ttc tca gaa gtg gtg      504
 Asp Leu Cys Gln Cys Leu Leu Leu Ser Lys Val Phe Ser Glu Val Val
     110                 115                 120

 atg cag gtg cag att cta gaa agc atg agg tgc tca gga act att cag      552
 Met Gln Val Gln Ile Leu Glu Ser Met Arg Cys Ser Gly Thr Ile Gln
 125                 130                 135                 140

 ggc aaa ttt cat tca tct cca cct gct aaa ccc cat tac cca tgg gct      600
 Gly Lys Phe His Ser Ser Pro Pro Ala Lys Pro His Tyr Pro Trp Ala
                 145                 150                 155

 tat gga cct gtt ttt aca aac atc tca tgg gca act act att tgc cac      648
 Tyr Gly Pro Val Phe Thr Asn Ile Ser Trp Ala Thr Thr Ile Cys His
             160                 165                 170

 ata cca aac taa ggc ttttcccata ccttgtaata tttaattttt gtaacaaccc      703
 Ile Pro Asn 
         175

 catgatatag atattaaact ataattttga agataaaaac atcaaaatat aaaagcaagt    763

 gctcctgggt gggactgtac tttggtcttc tagttgtaag ttgggtatta tttatgctct    823

 atcctgaaaa ggaaagtgca tttgagtgaa ctgggacttt tttatttcat ctaaatctga    883

 tttctcacct ttgacactat taatattttg aaccaatttt ttgggcattg taagaatttt    943

 aacagcatct gaaaaatata gcattaaacc actaaagcta aggaccctga tgaagtcact   1003

 gcaccctcca ctacctctac tggaacaggc actggtatcc actgctgaga gacccataga   1063

 cggttcacat cacaggactc tgtggagaca atccccagta ccaacttgga gccgggtaga   1123

 ctcggtgggt ggcgagaccc agaagagaga caacaatcac tgcagtcagc tcacaggaag   1183

 ccacatccat aggaaaaggg ggagagtaat acatcaaggg aacaccccaa gggacaaaag   1243

 aatctgaaca acagtcttca gccctagact ttcccaaatg agaaggaacc agaaaaccaa   1303

 ccttggtaat atgacaaaac aaggctcttc aacacccccc aaaatataat actagttcac   1363

 cggcaatgga tccaaaccaa gaagaaatcc ctgatttacc tgaaaaagaa ttcaggaggt   1423

 tattaagcta atcagggaga ggccagagaa aggcaaagcc caatgcaaga aaatccaaaa   1483

 aatgttacaa gaagtgaaga gagaaatatt caaggaaata gatggcttaa agtaaaaaca   1543

 atcaaaaatt caagaaactt tggacacact tttagaaatg caaaatgctc tggaaagtct   1603

 cagcaataga attgaactag tagaagaaaa aaattcagag cttaaagaca aggtcttcga   1663

 attaacccaa ttcaacaaag acaaagaaaa attaataaga aaatatgaac aaagcctcca   1723

 agaagtctgg gattatgtta aacaaccaaa cctaagaata atcaatgttc ctgaggaaga   1783

 agagaattct aaaagcctgg aaaacatatt tgggggaata attgaggaaa acttccctgg   1843

 ccttgctaga gacctagaca tccaaataca agaagcacaa agatcaccca ggaaattcat   1903

 caccaaaaga tcttcaccta ggtacactgt catcaggtta tccaaaggaa accattttaa   1963

 gagctgtgag cagaagcacc aggtaactta caaaggaaaa atctatcaga ttaacagcag   2023

 atttctcagc agaaacccta caagctaaga cagaattggg gccctatctt cagccccctc   2083

 aaacaaaaca attatcagcc aagaattttg tatacagcga aactaagcat catatttgaa   2143

 ggaaagatac agtcatcttc agacaaacaa atgccaagat aattcacacc aagccaccac   2203

 tacaagaact gataaaagga gctctaaata ttgaaacaaa tcctggaaaa cagagcttct   2263

 ttaaagcata aatcacgtgg gacctattaa aaaacacaca cacacaagtt aaaaagc      2320




      <210> 443
      <211> 2985
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (757)..(2817)

      <400> 443
 gtgaggcgag cctggagctc atttccaggc gcccttccct cttcggaact aagggagact     60

 tgtgggcttt tgcacactgg ctgtagggtt cccgggaaag actggagcag cgaacaggag    120

 ggagagaggt ggacaggcag agtctgcacc tgccgcctgc acctccgtta gggcgacagg    180

 gcagctggtg tttcgctcct ggagtgtgcc tacctcgcaa ggggggcgag ggccacaggc    240

 tgaggcgcct gcgtcccgga gtgcaccgct tggccgaggc aaggtgttgc tggggcaagg    300

 ctgctccgaa gcgaagtcgc gcaaaaggaa gagtctggga ggcaggcgac ttaggagagt    360

 ctagtcactg agagacagag gcagcatctg ccattctaac tacggagctg agtaatttag    420

 aaaccctcct taactctccc tttccagctc tccccaaagt ccacagaagc tctgctgaac    480

 tctagaaatc ttccctggct ggggggaagt ttactagtat cctctttggc taagacaggg    540

 agtggaaaaa acaggcgggg ctgtactgtc cgctgtttgg ggagacgcgg tcttcctcgc    600

 gcccccttca gccactccga ctgcctggga agtcccagcc cgcgctctcc ggaacccggc    660

 tcgccgtctc gccctggaca tggaactacg catctgagac ctgctggacg ttttgctggc    720

 cgttttgcaa gactcagctg tcaagaaaag tgaagg  atg aag cca cca ttt ctt     774
                                          Met Lys Pro Pro Phe Leu
                                            1               5

 ttg gcc ctt gtg gtc tgt tct gta gtc agc aca aat ctg aag atg gtg      822
 Leu Ala Leu Val Val Cys Ser Val Val Ser Thr Asn Leu Lys Met Val
              10                  15                  20

 tca aag aga aat tct gtg gat ggc tgc att gac tgg tca gtg gat ctc      870
 Ser Lys Arg Asn Ser Val Asp Gly Cys Ile Asp Trp Ser Val Asp Leu
          25                  30                  35

 aag aca tac atg gct ttg gca ggt gaa cca gtc cga gtg aaa tgt gcc      918
 Lys Thr Tyr Met Ala Leu Ala Gly Glu Pro Val Arg Val Lys Cys Ala
      40                  45                  50

 ctt ttc tac agt tat att cgt acc aac tat agc acg gcc cag agc act      966
 Leu Phe Tyr Ser Tyr Ile Arg Thr Asn Tyr Ser Thr Ala Gln Ser Thr
  55                  60                  65                  70

 ggg ctc agg ctt atg tgg tac aaa aac aaa ggt gat ttg gaa gag ccc     1014
 Gly Leu Arg Leu Met Trp Tyr Lys Asn Lys Gly Asp Leu Glu Glu Pro
                  75                  80                  85

 atc atc ttt tca gag gtc agg atg agc aaa gag gaa gat tca ata tgg     1062
 Ile Ile Phe Ser Glu Val Arg Met Ser Lys Glu Glu Asp Ser Ile Trp
              90                  95                 100

 ttt cac tca gct gag gca caa gac agt gga ttc tac act tgt gtt tta     1110
 Phe His Ser Ala Glu Ala Gln Asp Ser Gly Phe Tyr Thr Cys Val Leu
         105                 110                 115

 aga aac tca aca tat tgc atg aag gtg tca atg tcc ttg act gtt gca     1158
 Arg Asn Ser Thr Tyr Cys Met Lys Val Ser Met Ser Leu Thr Val Ala
     120                 125                 130

 gag aat gaa tca ggc ctg tgc tac aac agc agg atc cgc tat tta gaa     1206
 Glu Asn Glu Ser Gly Leu Cys Tyr Asn Ser Arg Ile Arg Tyr Leu Glu
 135                 140                 145                 150

 aaa tct gaa gtc act aaa aga aag gag atc tcc tgt cca gac atg gat     1254
 Lys Ser Glu Val Thr Lys Arg Lys Glu Ile Ser Cys Pro Asp Met Asp
                 155                 160                 165

 gac ttt aaa aag tcc gat cag gag cct gat gtt gtg tgg tat aag gaa     1302
 Asp Phe Lys Lys Ser Asp Gln Glu Pro Asp Val Val Trp Tyr Lys Glu
             170                 175                 180

 tgc aag cca aaa atg tgg aga agc ata ata ata cag aaa gga aat gct     1350
 Cys Lys Pro Lys Met Trp Arg Ser Ile Ile Ile Gln Lys Gly Asn Ala
         185                 190                 195

 ctt ctg atc caa gaa gtt caa gaa gaa gat gga gga aat tac aca tgt     1398
 Leu Leu Ile Gln Glu Val Gln Glu Glu Asp Gly Gly Asn Tyr Thr Cys
     200                 205                 210

 gaa ctt aaa tat gaa gga aaa ctt gta aga cga aca act gaa ttg aaa     1446
 Glu Leu Lys Tyr Glu Gly Lys Leu Val Arg Arg Thr Thr Glu Leu Lys
 215                 220                 225                 230

 gtt aca gct tta ctc aca gac aag cct ccc aag cca ttg ttc ccc atg     1494
 Val Thr Ala Leu Leu Thr Asp Lys Pro Pro Lys Pro Leu Phe Pro Met
                 235                 240                 245

 gag aat cag cca agt gtt ata gat gtc cag ctg ggt aag cct ctg aac     1542
 Glu Asn Gln Pro Ser Val Ile Asp Val Gln Leu Gly Lys Pro Leu Asn
             250                 255                 260

 atc ccc tgc aaa gca ttc ttc gga ttc agt gga gag tct ggg cca atg     1590
 Ile Pro Cys Lys Ala Phe Phe Gly Phe Ser Gly Glu Ser Gly Pro Met
         265                 270                 275

 atc tac tgg atg aaa gga gaa aag ttt att gaa gaa ctg gca ggt cac     1638
 Ile Tyr Trp Met Lys Gly Glu Lys Phe Ile Glu Glu Leu Ala Gly His
     280                 285                 290

 att aga gaa ggt gaa ata agg ctt ctc aaa gag cat ctt gga gaa aaa     1686
 Ile Arg Glu Gly Glu Ile Arg Leu Leu Lys Glu His Leu Gly Glu Lys
 295                 300                 305                 310

 gaa gtt gaa ttg gca ctc atc ttt gac tca gtt gtg gaa gct gac ctg     1734
 Glu Val Glu Leu Ala Leu Ile Phe Asp Ser Val Val Glu Ala Asp Leu
                 315                 320                 325

 gcg aat tat acc tgc cat gtt gaa aac cga aat gga cgg aaa cat gcc     1782
 Ala Asn Tyr Thr Cys His Val Glu Asn Arg Asn Gly Arg Lys His Ala
             330                 335                 340

 agt gtt ttg ctg cgt aaa aag gat tta atc tat aaa att gag ctt gca     1830
 Ser Val Leu Leu Arg Lys Lys Asp Leu Ile Tyr Lys Ile Glu Leu Ala
         345                 350                 355

 ggg ggc ctg gga gca atc ttc ctc ctc ctt gta ctg ctg gtg gtc att     1878
 Gly Gly Leu Gly Ala Ile Phe Leu Leu Leu Val Leu Leu Val Val Ile
     360                 365                 370

 tac aaa tgc tac aac att gaa ttg atg ctc ttc tac agg cag cac ttt     1926
 Tyr Lys Cys Tyr Asn Ile Glu Leu Met Leu Phe Tyr Arg Gln His Phe
 375                 380                 385                 390

 gga gct gat gaa act aat gat gac aac aag gaa tat gat gcc tat ctc     1974
 Gly Ala Asp Glu Thr Asn Asp Asp Asn Lys Glu Tyr Asp Ala Tyr Leu
                 395                 400                 405

 tct tac aca aaa gtg gac caa gat act tta gac tgt gac aat cct gaa     2022
 Ser Tyr Thr Lys Val Asp Gln Asp Thr Leu Asp Cys Asp Asn Pro Glu
             410                 415                 420

 gaa gag cag ttt gct ctt gaa gta ctg cca gat gtc ctg gaa aaa cac     2070
 Glu Glu Gln Phe Ala Leu Glu Val Leu Pro Asp Val Leu Glu Lys His
         425                 430                 435

 tat gga tat aaa ctc ttc atc cca gaa aga gac ctg att cca agt gga     2118
 Tyr Gly Tyr Lys Leu Phe Ile Pro Glu Arg Asp Leu Ile Pro Ser Gly
     440                 445                 450

 aca tac atg gaa gat ctc aca aga tat gtt gaa caa agc aga aga ctt     2166
 Thr Tyr Met Glu Asp Leu Thr Arg Tyr Val Glu Gln Ser Arg Arg Leu
 455                 460                 465                 470

 att atc gtg cta act cca gac tat att ctc aga cgg gga tgg agt att     2214
 Ile Ile Val Leu Thr Pro Asp Tyr Ile Leu Arg Arg Gly Trp Ser Ile
                 475                 480                 485

 ttc gaa ctg gaa agc aga ctc cat aac atg cta gtc agt gga gaa atc     2262
 Phe Glu Leu Glu Ser Arg Leu His Asn Met Leu Val Ser Gly Glu Ile
             490                 495                 500

 aaa gtg att ttg att gag tgt aca gaa tta aaa ggg aaa gtg aat tgc     2310
 Lys Val Ile Leu Ile Glu Cys Thr Glu Leu Lys Gly Lys Val Asn Cys
         505                 510                 515

 cag gaa gtg gaa tca cta aag cgt agc atc aaa ctt ctg tcc ctg atc     2358
 Gln Glu Val Glu Ser Leu Lys Arg Ser Ile Lys Leu Leu Ser Leu Ile
     520                 525                 530

 aag tgg aag gga tcc aaa agc agc aaa tta aat tct aag ttt tgg aag     2406
 Lys Trp Lys Gly Ser Lys Ser Ser Lys Leu Asn Ser Lys Phe Trp Lys
 535                 540                 545                 550

 cac tta gta tat gaa atg ccc atc aag aaa aaa gaa atg cta cct cgg     2454
 His Leu Val Tyr Glu Met Pro Ile Lys Lys Lys Glu Met Leu Pro Arg
                 555                 560                 565

 tgc cat gtt ctg gac tcc gca gaa caa gga ctt ttt gga gaa ctc cag     2502
 Cys His Val Leu Asp Ser Ala Glu Gln Gly Leu Phe Gly Glu Leu Gln
             570                 575                 580

 cct ata ccc tct att gcc atg acc agt act tca gcc act ctg gtg tca     2550
 Pro Ile Pro Ser Ile Ala Met Thr Ser Thr Ser Ala Thr Leu Val Ser
         585                 590                 595

 tct cag gct gat ctc cct gaa ttc cac cct tca gat tca atg caa atc     2598
 Ser Gln Ala Asp Leu Pro Glu Phe His Pro Ser Asp Ser Met Gln Ile
     600                 605                 610

 agg cac tgt tgc aga ggt tat aaa cat gag ata cca gcc acg acc ttg     2646
 Arg His Cys Cys Arg Gly Tyr Lys His Glu Ile Pro Ala Thr Thr Leu
 615                 620                 625                 630

 cca gta cct tcc tta ggc aac cac cat act tat tgt aac ctg cct ctg     2694
 Pro Val Pro Ser Leu Gly Asn His His Thr Tyr Cys Asn Leu Pro Leu
                 635                 640                 645

 acg cta ctc aac gga cag cta ccc ctt aat aac acc ctg aaa gat acc     2742
 Thr Leu Leu Asn Gly Gln Leu Pro Leu Asn Asn Thr Leu Lys Asp Thr
             650                 655                 660

 cag gaa ttt cac agg aac agt tct ttg ctg cct tta tcc tcc aaa gag     2790
 Gln Glu Phe His Arg Asn Ser Ser Leu Leu Pro Leu Ser Ser Lys Glu
         665                 670                 675

 ctt agc ttt acc agt gat att tgg tag tgaaa aatctgaatt cctctgaaca     2842
 Leu Ser Phe Thr Ser Asp Ile Trp 
     680                 685

 gctagataag catagagaat ttctgttata ccaagcataa agtacaccta ataacgttgt   2902

 gttaaaaaag tgtttgaaga aaaaggtaca aaaatggctt ttatacttaa atatttttgt   2962

 ttacatttcc agaatagtgg ggg                                           2985




      <210> 444
      <211> 2309
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (361)..(1770)

      <400> 444
 gatttgggga gttatgcgcc agtgccccag tgaccgcggg acacggagag gggaagtctg     60

 cgttgtacat aaggacctag ggactccgag cttggcctga gaacccttgg acgccgagtg    120

 cttgccttac gggctgcact cctcaactct gctccaaagc agccgctgag ctcaactcct    180

 gcgtccaggg cgttcgctgc gcgccaggac gcgcttagta cccagttcct gggctctctc    240

 ttcagtagct gctttgaaag ctcccacgcg cgtcccgcag gctagcctgg caacaaaact    300

 ggggtaaacc gtgttatctt aggtcttgtc ccccagaaca tgacctagag gtacctgcgc    360
                                                                 
 atg cag atg gcc gat gca gcc acg ata gcc acc atg aat aag gca gca      408
 Met Gln Met Ala Asp Ala Ala Thr Ile Ala Thr Met Asn Lys Ala Ala
   1               5                  10                  15

 ggc ggg gac aag cta gca gaa ctc ttc agt ctg gtc ccg gac ctt ctg      456
 Gly Gly Asp Lys Leu Ala Glu Leu Phe Ser Leu Val Pro Asp Leu Leu
              20                  25                  30

 gag gcg gcc aac acg agt ggt aac gcg tcg ctg cag ctt ccg gac ttg      504
 Glu Ala Ala Asn Thr Ser Gly Asn Ala Ser Leu Gln Leu Pro Asp Leu
          35                  40                  45

 tgg tgg gag ctg ggg ctg gag ttg ccg gac ggc gcg ccg cca gga cat      552
 Trp Trp Glu Leu Gly Leu Glu Leu Pro Asp Gly Ala Pro Pro Gly His
      50                  55                  60

 ccc ccg ggc agc ggc ggg gca gag agc gcg gac aca gag gcc cgg gtg      600
 Pro Pro Gly Ser Gly Gly Ala Glu Ser Ala Asp Thr Glu Ala Arg Val
  65                  70                  75                  80

 cgg att ctc atc agc gtg gtg tac tgg gtg gtg tgc gcc ctg ggg ttg      648
 Arg Ile Leu Ile Ser Val Val Tyr Trp Val Val Cys Ala Leu Gly Leu
                  85                  90                  95

 gcg ggc aac ctg ctg gtt ctc tac ctg atg aag agc atg cag ggc tgg      696
 Ala Gly Asn Leu Leu Val Leu Tyr Leu Met Lys Ser Met Gln Gly Trp
             100                 105                 110

 cgc aag tcc tct atc aac ctc ttc gtc acc aac ctg gcg ctg acg gac      744
 Arg Lys Ser Ser Ile Asn Leu Phe Val Thr Asn Leu Ala Leu Thr Asp
         115                 120                 125

 ttt cag ttt gtg ctc acc ctg ccc ttc tgg gcg gtg gag aac gct ctt      792
 Phe Gln Phe Val Leu Thr Leu Pro Phe Trp Ala Val Glu Asn Ala Leu
     130                 135                 140

 gac ttc aaa tgg ccc ttc ggc aag gcc atg tgt aag atc gtg tcc atg      840
 Asp Phe Lys Trp Pro Phe Gly Lys Ala Met Cys Lys Ile Val Ser Met
 145                 150                 155                 160

 gtg acg tcc atg aac atg tac gcc agc gtg ttc ttc ctc act gcc atg      888
 Val Thr Ser Met Asn Met Tyr Ala Ser Val Phe Phe Leu Thr Ala Met
                 165                 170                 175

 agt gtg acg cgc tac cat tcg gtg gcc tcg gct ctg aag agc cac cgg      936
 Ser Val Thr Arg Tyr His Ser Val Ala Ser Ala Leu Lys Ser His Arg
             180                 185                 190

 acc cga gga cac ggc cgg ggc gac tgc tgc ggc cgg agc ctg ggg gac      984
 Thr Arg Gly His Gly Arg Gly Asp Cys Cys Gly Arg Ser Leu Gly Asp
         195                 200                 205

 agc tgc tgc ttc tcg gcc aag gcg ctg tgt gtg tgg atc tgg gct ttg     1032
 Ser Cys Cys Phe Ser Ala Lys Ala Leu Cys Val Trp Ile Trp Ala Leu
     210                 215                 220

 gcc gcg ctg gcc tcg ctg ccc agt gcc att ttc tcc acc acg gtc aag     1080
 Ala Ala Leu Ala Ser Leu Pro Ser Ala Ile Phe Ser Thr Thr Val Lys
 225                 230                 235                 240

 gtg atg ggc gag gag ctg tgc ctg gtg cgt ttc ccg gac aag ttg ctg     1128
 Val Met Gly Glu Glu Leu Cys Leu Val Arg Phe Pro Asp Lys Leu Leu
                 245                 250                 255

 ggc cgc gac agg cag ttc tgg ctg ggc ctc tac cac tcg cag aag gtg     1176
 Gly Arg Asp Arg Gln Phe Trp Leu Gly Leu Tyr His Ser Gln Lys Val
             260                 265                 270

 ctg ttg ggc ttc gtg ctg ccg ctg ggc atc att atc ttg tgc tac ctg     1224
 Leu Leu Gly Phe Val Leu Pro Leu Gly Ile Ile Ile Leu Cys Tyr Leu
         275                 280                 285

 ctg ctg gtg cgc ttc atc gcc gac cgc cgc gcg gcg ggg acc aaa gga     1272
 Leu Leu Val Arg Phe Ile Ala Asp Arg Arg Ala Ala Gly Thr Lys Gly
     290                 295                 300

 ggg gcc gcg gta gcc gga gga cgc ccg acc gga gcc agc gcc cgg aga     1320
 Gly Ala Ala Val Ala Gly Gly Arg Pro Thr Gly Ala Ser Ala Arg Arg
 305                 310                 315                 320

 ctg tcg aag gtc acc aaa tca gtg acc atc gtt gtc ctg tcc ttc ttc     1368
 Leu Ser Lys Val Thr Lys Ser Val Thr Ile Val Val Leu Ser Phe Phe
                 325                 330                 335

 ctg tgt tgg ctg ccc aac cag gcg ctc acc acc tgg agc atc ctc atc     1416
 Leu Cys Trp Leu Pro Asn Gln Ala Leu Thr Thr Trp Ser Ile Leu Ile
             340                 345                 350

 aag ttc aac gcg gtg ccc ttc agc cag gag tat ttc ctg tgc cag gta     1464
 Lys Phe Asn Ala Val Pro Phe Ser Gln Glu Tyr Phe Leu Cys Gln Val
         355                 360                 365

 tac gcg ttc cct gtg agc gtg tgc cta gcg cac tcc aac agc tgc ctc     1512
 Tyr Ala Phe Pro Val Ser Val Cys Leu Ala His Ser Asn Ser Cys Leu
     370                 375                 380

 aac ccc gtc ctc tac tgc ctc gtg cgc cgc gag ttc cgc aag gcg ctc     1560
 Asn Pro Val Leu Tyr Cys Leu Val Arg Arg Glu Phe Arg Lys Ala Leu
 385                 390                 395                 400

 aag agc ctg ctg tgg cgc atc gcg tct cct tcg atc acc agc atg cgc     1608
 Lys Ser Leu Leu Trp Arg Ile Ala Ser Pro Ser Ile Thr Ser Met Arg
                 405                 410                 415

 ccc ttc acc gcc act acc aag ccg gag cac gag gat cag ggg ctg cag     1656
 Pro Phe Thr Ala Thr Thr Lys Pro Glu His Glu Asp Gln Gly Leu Gln
             420                 425                 430

 gcc ccg gcg ccg ccc cac gcg gcc gcg gag ccg gac ctg ctc tac tac     1704
 Ala Pro Ala Pro Pro His Ala Ala Ala Glu Pro Asp Leu Leu Tyr Tyr
         435                 440                 445

 cca cct ggc gtc gtg gtc tac agc ggg ggg cgc tac gac ctg ctg ccc     1752
 Pro Pro Gly Val Val Val Tyr Ser Gly Gly Arg Tyr Asp Leu Leu Pro
     450                 455                 460

 agc agc tct gcc tac tga cgcagg cctcaggccc agggcgcgcc gtcggggcaa     1806
 Ser Ser Ser Ala Tyr 
 465

 ggtggccttc cccgggcggt aaagaggtga aaggatgaag gagggctggg gggggcccca   1866

 tttaagaagt aggtgggagg aggatgggca gagcatggag gaggagcctg tggataggcc   1926

 gaggaccttc tctggagagg agatgcttcg aaatcgggtg gagagaggaa attggcaaag   1986

 ggatagagac gagccccacg ggccagacag ccaacctccg ctccgcaccc cacagcctct   2046

 ccttactctt cccacgctga gtagtgtggg ggcgcccaga agcgaagaca agcagcaaaa   2106

 atgtagagaa attggcacga ggagcggggc ttagccaaat gatgcacaga caattgtgcc   2166

 cgtttaatcc agcgacttct gcggagaagg cagccgtcgg cacaaacact cctttgcgtc   2226

 tggcaaacga actgaacacg ccaggtctac ttgctccggt tgcccagaac cagagctgtg   2286

 gcaaaaagct ttggattaaa aaa                                           2309




      <210> 445
      <211> 651
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(597)

      <400> 445
 tggggaacaa ctgccaggga gctgttccag ggcccacaca gaaaaaggcc tcgctaacgc     60

 aacaaacctg atcattgtca acaaccatag gactgaggtg aagcc    atg aag ttc     114
                                                      Met Lys Phe
                                                        1

 ttg ctg atc tcc cta gcc cta tgg ctg ggc aca ggg ggc aca cgt ggg      162
 Leu Leu Ile Ser Leu Ala Leu Trp Leu Gly Thr Gly Gly Thr Arg Gly
       5                  10                  15

 aca gag ccc gaa ctc atc gag acc cag cgc agg agc cta cag gtg gct      210
 Thr Glu Pro Glu Leu Ile Glu Thr Gln Arg Arg Ser Leu Gln Val Ala
  20                  25                  30                  35

 ttg gag gag ttc cac aaa cac cca cct gtg cag ttg gcc ttc caa gag      258
 Leu Glu Glu Phe His Lys His Pro Pro Val Gln Leu Ala Phe Gln Glu
                  40                  45                  50

 atc ggt gtg gac aga gct gaa gaa gtg ctc ttc tca gct ggc acc ttt      306
 Ile Gly Val Asp Arg Ala Glu Glu Val Leu Phe Ser Ala Gly Thr Phe
              55                  60                  65

 gtg agg ttg gaa ttt aag ctc cag cag acc aac tgc ccc aag aag gac      354
 Val Arg Leu Glu Phe Lys Leu Gln Gln Thr Asn Cys Pro Lys Lys Asp
          70                  75                  80

 tgg aaa aag ccg gag tgc aca atc aaa cca aac ggg aga agg cgg aaa      402
 Trp Lys Lys Pro Glu Cys Thr Ile Lys Pro Asn Gly Arg Arg Arg Lys
      85                  90                  95

 tgc ctg gcc tgc att aaa atg gac ccc aag ggt aaa att cta ggc cgg      450
 Cys Leu Ala Cys Ile Lys Met Asp Pro Lys Gly Lys Ile Leu Gly Arg
 100                 105                 110                 115

 ata gtc cac tgc cca att ctg aag caa ggg cct cag cag gat cct cag      498
 Ile Val His Cys Pro Ile Leu Lys Gln Gly Pro Gln Gln Asp Pro Gln
                 120                 125                 130

 gag ttg caa tgc att aag ata gca cag gct ggc gaa gac ccc cac ggc      546
 Glu Leu Gln Cys Ile Lys Ile Ala Gln Ala Gly Glu Asp Pro His Gly
             135                 140                 145

 tac ttc cta cct gga cag ttt gcc ttc tcc agg gcc ctg aga acc aaa      594
 Tyr Phe Leu Pro Gly Gln Phe Ala Phe Ser Arg Ala Leu Arg Thr Lys
         150                 155                 160

 taa gccc tagacaggac ttcaccttac tccctgtaca gctgtggcag cacccagcag      651
 






      <210> 446
      <211> 2653
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1055)..(2149)

      <400> 446
 ctgctggtgg ccgtgggcac ggatgtcttc caggctcacc agaaggacac agagcgctat     60

 gtgctcacca acctcaacat cggggcagaa ctgcttcggg acccggtccc tgggggctca    120

 gtttcgggtg cacctggtga agatggtcat tctgacagag cctgagggtg ctccaaatat    180

 cacagccaac ctcacctcgt ccctgctgag cgtctgtggg tggagccaga ccatcaaccc    240

 tgaggacgac acggatcctg gccatgctga cctggtcctc tatatcacta ggtttgacct    300

 ggagttgcct gatggtaacc ggcaggtgcg gggcgtcacc cagctgggcg gtgcctgctc    360

 cccaacctgg agctgcctca ttaccgagga cactggcttc gacctgggag tcaccattgc    420

 ccatgagatt gggcacagct tcggcctgga gcacgacggc gcgcccggca gcggctgcgg    480

 ccccagcgga cacgtgatgg cttcggacgg cgccgcgccc cgcgccggcc tcgcctggtc    540

 cccctgcagc cgccggcagc tgctgagcct gctcagaccc gtccctccgt cgccgctccc    600

 tctgctggcc acccacctct gcgccggcag gagccttagt cttggtccca gccaagagcc    660

 ggctcctggt ggggggcgcg ggccgagaac tcctgttccc actcacaaaa ggccacgctt    720

 ccaaacgctt ccatcctcgt gcccactcct ccgtcccgcc tcctcccggt gtacaccccg    780

 ggactgagcc gggcctgagc cgggccttgt cgcagcgcat gacgggcgcg ctggtgtggg    840

 acccgccgcg gcctcaaccc gggtccgcgg ggcacccgcg gaatgcgcac ctgggcctct    900

 actacagcgc caacgagcag tgccgcgtgg ccttcggccc caaggctgtc gcctgcacct    960

 tcgccaggga gcacctggtg agtctgccgg cggtggcctg ggattggctg tgaggtccct   1020

 ccgcatcacc cagctcacgt ccccccaaac gtgc    atg gat atg tgc cag gcc    1072
                                          Met Asp Met Cys Gln Ala
                                            1               5

 ctc tcc tgc cac aca gac ccg ctg gac caa agc agc tgc agc cgc ctc     1120
 Leu Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu
              10                  15                  20

 ctc gtt cct ctc ctg gat ggg aca gaa tgt ggc gtg gag aag tgg tgc     1168
 Leu Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys
          25                  30                  35

 tcc aag ggt cgc tgc cgc tcc ctg gtg gag ctg acc ccc ata gca gca     1216
 Ser Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala
      40                  45                  50

 gtg cat ggg cgc tgg tct agc tgg ggt ccc cga agt cct tgc tcc cgc     1264
 Val His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg
  55                  60                  65                  70

 tcc tgc gga gga ggt gtg gtc acc agg agg cgg cag tgc aac aac ccc     1312
 Ser Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro
                  75                  80                  85

 aga cct gcc ttt ggg ggg cgt gca tgt gtt ggt gct gac ctc cag gcc     1360
 Arg Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala
              90                  95                 100

 gag atg tgc aac act cag gcc tgc gag aag acc cag ctg gag ttc atg     1408
 Glu Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met
         105                 110                 115

 tcg caa cag tgc gcc agg acc gac ggc cag ccg ctg cgc tcc tcc cct     1456
 Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro
     120                 125                 130

 ggc ggc gcc tcc ttc tac cac tgg ggt gct gct gta cca cac agc caa     1504
 Gly Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln
 135                 140                 145                 150

 ggg gat gct ctg tgc aga cac atg tgc cgg gcc att ggc gag agc ttc     1552
 Gly Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe
                 155                 160                 165

 atc atg aag cgt gga gac agc ttc ctc gat ggg acc cgg tgt atg cca     1600
 Ile Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro
             170                 175                 180

 agt ggc ccc cgg gag gac ggg acc ctg agc ctg tgt gtg tcg ggc agc     1648
 Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser
         185                 190                 195

 tgc agg aca ttt ggc tgt gat ggt agg atg gac tcc cag cag gta tgg     1696
 Cys Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp
     200                 205                 210

 gac agg tgc cag gtg tgt ggt ggg gac aac agc acg tgc agc cca cgg     1744
 Asp Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg
 215                 220                 225                 230

 aag ggc tct ttc aca gct ggc aga gcg aga gaa tat gtc acg ttt ctg     1792
 Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu
                 235                 240                 245

 aca gtt acc ccc aac ctg acc agt gtc tac att gcc aac cac agg cct     1840
 Thr Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro
             250                 255                 260

 ctc ttc aca cac ttg gcg gtg agg atc gga ggg cgc tat gtc gtg gct     1888
 Leu Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala
         265                 270                 275

 ggg aag atg agc atc tcc cct aac acc acc tac ccc tcc ctc ctg gag     1936
 Gly Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu
     280                 285                 290

 gat ggt cgt gtc gag tac aga gtg gcc ctc acc gag gac cgg ctg ccc     1984
 Asp Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro
 295                 300                 305                 310

 cgc ctg gag gag atc cgc atc tgg gga ccc ctc cag gaa gat gct gac     2032
 Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp
                 315                 320                 325

 atc cag gtg gga ggt gtc aga gcc cag ctc atg cac atc agc tgg tgg     2080
 Ile Gln Val Gly Gly Val Arg Ala Gln Leu Met His Ile Ser Trp Trp
             330                 335                 340

 agc agg cct ggc ctt gga gaa cga gac ctg tgt gcc agg ggc aga tgg     2128
 Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu Cys Ala Arg Gly Arg Trp
         345                 350                 355

 cct gga ggc tcc agt gac tga gg ggcctggctc cgtagatgag aagctgcctg     2181
 Pro Gly Gly Ser Ser Asp 
     360

 cccctgagcc ctgtgtcggg atgtcatgtc ctccaggctg gggccatctg gatgccacct   2241

 ctgcagggga gaaggctccc tccccatggg gcagcatcag gacgggggct caagctgcac   2301

 acgtgtggac ccctgcggca gggtcgtgct ccgtctcctg cgggcgaggt ctgatggagc   2361

 tgcgtttcct gtgcatggac tctgccctca gggtgcctgt ccaggaagag ctgtgtggcc   2421

 tggcaagcaa gcctgggagc cggcgggagg tctgccaggc tgtcccgtgc cctgctcggt   2481

 ggcagtacaa gctggcggcc tgcagcgtga gctgtgggag aggggtcgtg cggaggatcc   2541

 tgtattgtgc ccgggcccat ggggaggacg atggtgagga gatcctgttg gacacccagt   2601

 gccaggggct gcctcgcccg gaaccccagg aggcctgcag cctggagccc tg           2653


      <210> 447
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 447
 Met Lys Met Met Val Val Leu Leu Met Leu Ser Ser Leu Ser Arg Leu
   1               5                  10                  15    
 Leu Gly Leu Met Arg Pro Ser Ser Leu Arg Gln Tyr Leu Asp Ser Val
              20                  25                  30        
 Pro Leu Pro Pro Cys Gln Glu Gln Gln Pro Lys Ala Ser Ala Glu Leu
          35                  40                  45            
 Asp His Lys Ala Cys Tyr Leu Cys His Ser Leu Leu Met Leu Ala Gly
      50                  55                  60                
 Val Val Val Ser Cys Gln Asp Ile Thr Pro Asp Gln Trp Gly Glu Leu
  65                  70                  75                  80
 Gln Leu Leu Cys Met Gln Leu Asp Arg His Ile Ser Thr Gln Ile Arg
                  85                  90                  95    
 Glu Ser Pro Gln Ala Met His Arg Thr Met Leu Lys Asp Leu Ala Thr
             100                 105                 110        
 Gln Thr Tyr Ile Arg Trp Gln Glu Leu Leu Thr His Cys Gln Pro Gln
         115                 120                 125            
 Ala Gln Tyr Phe Ser Pro Trp Lys Asp Ile
     130                 135            



      <210> 448
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 448
 Met Ala Asp Ser Gly Thr Ala Gly Gly Ala Ala Leu Ala Ala Pro Ala
   1               5                  10                  15    
 Pro Gly Pro Gly Ser Gly Gly Pro Gly Pro Arg Val Tyr Phe Gln Ser
              20                  25                  30        
 Pro Pro Gly Ala Ala Gly Glu Gly Pro Gly Gly Ala Asp Asp Glu Gly
          35                  40                  45            
 Pro Val Arg Arg Gln Gly Lys Val Thr Val Lys Tyr Asp Arg Lys Glu
      50                  55                  60                
 Leu Arg Lys Arg Leu Asn Leu Glu Glu Trp Ile Leu Glu Gln Leu Thr
  65                  70                  75                  80
 Arg Leu Tyr Asp Cys Gln Glu Glu Glu Ile Pro Glu Leu Glu Ile Asp
                  85                  90                  95    
 Val Asp Glu Leu Leu Asp Met Glu Ser Asp Asp Ala Arg Ala Ala Arg
             100                 105                 110        
 Val Lys Glu Leu Leu Val Asp Cys Tyr Lys Pro Thr Glu Ala Phe Ile
         115                 120                 125            
 Ser Gly Leu Leu Asp Lys Ile Arg Gly Met Gln Lys Leu Ser Thr Pro
     130                 135                 140                
 Gln Lys Lys
 145        



      <210> 449
      <211> 441
      <212> PRT
      <213> Homo sapiens


      <400> 449
 Met Asp Asp Asp Asp Phe Gly Gly Phe Glu Ala Ala Glu Thr Phe Asp
   1               5                  10                  15    
 Gly Gly Ser Gly Glu Thr Gln Thr Thr Ser Pro Ala Ile Pro Trp Ala
              20                  25                  30        
 Ala Phe Pro Ala Val Ser Gly Val His Leu Ser Pro Ser Ser Pro Glu
          35                  40                  45            
 Ile Val Leu Asp Arg Asp His Ser Ser Ser Ile Gly Cys Leu Ser Ser
      50                  55                  60                
 Asp Ala Ile Ile Ser Ser Pro Glu Asn Thr His Ala Ala Asn Ser Ile
  65                  70                  75                  80
 Val Ser Gln Thr Ile Pro Lys Ala Gln Ile Gln Gln Ser Thr His Thr
                  85                  90                  95    
 His Leu Asp Ile Ser Leu Phe Pro Leu Gly Leu Thr Asp Glu Lys Ser
             100                 105                 110        
 Asn Gly Thr Ile Ala Leu Val Asp Asp Ser Glu Asp Pro Gly Ala Asn
         115                 120                 125            
 Val Ser Asn Ile Gln Leu Gln Gln Lys Ile Ser Ser Leu Glu Ile Lys
     130                 135                 140                
 Leu Lys Val Ser Glu Glu Glu Lys Gln Arg Ile Lys Gln Asp Val Glu
 145                 150                 155                 160
 Ser Leu Met Glu Lys His Asn Val Leu Glu Lys Gly Phe Leu Lys Glu
                 165                 170                 175    
 Lys Glu Gln Glu Ala Ile Ser Phe Gln Asp Arg Tyr Lys Glu Leu Gln
             180                 185                 190        
 Glu Lys His Lys Gln Glu Leu Glu Asp Met Arg Lys Ala Gly His Glu
         195                 200                 205            
 Ala Leu Ser Ile Ile Val Asp Glu Tyr Lys Ala Leu Leu Gln Ser Ser
     210                 215                 220                
 Val Lys Gln Gln Val Glu Ala Ile Glu Lys Gln Tyr Ile Ser Ala Ile
 225                 230                 235                 240
 Glu Lys Gln Ala His Lys Cys Glu Glu Leu Leu Asn Ala Gln His Gln
                 245                 250                 255    
 Arg Leu Leu Glu Met Leu Asp Thr Glu Lys Glu Leu Leu Lys Glu Lys
             260                 265                 270        
 Ile Lys Glu Ala Leu Ile Gln Gln Ser Gln Glu Gln Lys Glu Ile Leu
         275                 280                 285            
 Glu Lys Cys Leu Glu Glu Glu Arg Gln Arg Asn Lys Glu Ala Leu Val
     290                 295                 300                
 Ser Ala Ala Lys Leu Glu Lys Glu Ala Val Lys Asp Ala Val Leu Lys
 305                 310                 315                 320
 Val Val Glu Glu Glu Arg Lys Asn Leu Glu Lys Ala His Ala Glu Glu
                 325                 330                 335    
 Arg Glu Leu Trp Lys Thr Glu His Ala Lys Asp Gln Glu Lys Val Ser
             340                 345                 350        
 Gln Glu Ile Gln Lys Ala Ile Gln Glu Gln Arg Lys Ile Ser Gln Glu
         355                 360                 365            
 Thr Val Lys Ala Ala Ile Ile Glu Glu Gln Lys Arg Ser Glu Lys Ala
     370                 375                 380                
 Val Glu Glu Ala Val Lys Arg Thr Arg Asp Glu Leu Ile Glu Tyr Ile
 385                 390                 395                 400
 Lys Glu Gln Lys Arg Leu Asp Gln Val Ile Arg Gln Arg Ser Leu Ser
                 405                 410                 415    
 Ser Leu Glu Leu Phe Leu Ser Cys Ala Gln Lys Gln Leu Ser Ala Leu
             420                 425                 430        
 Ile Ala Thr Glu Pro Val Asp Ile Glu
         435                 440    



      <210> 450
      <211> 410
      <212> PRT
      <213> Homo sapiens


      <400> 450
 Met Asp Asp Asp Asp Phe Gly Gly Phe Glu Ala Ala Glu Thr Phe Asp
   1               5                  10                  15    
 Gly Gly Ser Gly Glu Thr Gln Thr Thr Ser Pro Ala Ile Pro Trp Ala
              20                  25                  30        
 Ala Phe Pro Ala Val Ser Gly Val His Leu Ser Pro Ser Ser Pro Glu
          35                  40                  45            
 Ile Val Leu Asp Arg Asp His Ser Ser Ser Ile Gly Cys Leu Ser Ser
      50                  55                  60                
 Asp Ala Ile Ile Ser Ser Pro Glu Asn Thr His Ala Ala Asn Ser Ile
  65                  70                  75                  80
 Val Ser Gln Thr Ile Pro Lys Ala Gln Ile Gln Gln Ser Thr His Thr
                  85                  90                  95    
 His Leu Asp Ile Ser Leu Phe Pro Leu Gly Leu Thr Asp Glu Lys Ser
             100                 105                 110        
 Asn Gly Thr Ile Ala Leu Val Asp Asp Ser Glu Asp Pro Gly Ala Asn
         115                 120                 125            
 Val Ser Asn Ile Gln Leu Gln Gln Lys Ile Ser Ser Leu Glu Ile Lys
     130                 135                 140                
 Leu Lys Val Ser Glu Glu Glu Lys Gln Arg Ile Lys Gln Asp Val Glu
 145                 150                 155                 160
 Ser Leu Met Glu Lys His Asn Val Leu Glu Lys Gly Phe Leu Lys Glu
                 165                 170                 175    
 Lys Glu Gln Glu Ala Ile Ser Phe Gln Asp Arg Tyr Lys Glu Leu Gln
             180                 185                 190        
 Glu Lys His Lys Gln Glu Leu Glu Asp Met Arg Lys Ala Gly His Glu
         195                 200                 205            
 Ala Leu Ser Ile Ile Val Asp Glu Tyr Lys Ala Leu Leu Gln Ser Ser
     210                 215                 220                
 Val Lys Gln Gln Val Glu Ala Ile Glu Lys Gln Tyr Ile Ser Ala Ile
 225                 230                 235                 240
 Glu Lys Gln Ala His Lys Cys Glu Glu Leu Leu Asn Ala Gln Glu Ile
                 245                 250                 255    
 Leu Glu Lys Cys Leu Glu Glu Glu Arg Gln Arg Asn Lys Glu Ala Leu
             260                 265                 270        
 Val Ser Ala Ala Lys Leu Glu Lys Glu Ala Val Lys Asp Ala Val Leu
         275                 280                 285            
 Lys Val Val Glu Glu Glu Arg Lys Asn Leu Glu Lys Ala His Ala Glu
     290                 295                 300                
 Glu Arg Glu Leu Trp Lys Thr Glu His Ala Lys Asp Gln Glu Lys Val
 305                 310                 315                 320
 Ser Gln Glu Ile Gln Lys Ala Ile Gln Glu Gln Arg Lys Ile Ser Gln
                 325                 330                 335    
 Glu Thr Val Lys Ala Ala Ile Ile Glu Glu Gln Lys Arg Ser Glu Lys
             340                 345                 350        
 Ala Val Glu Glu Ala Val Lys Arg Thr Arg Asp Glu Leu Ile Glu Tyr
         355                 360                 365            
 Ile Lys Glu Gln Lys Arg Leu Asp Gln Val Ile Arg Gln Arg Ser Leu
     370                 375                 380                
 Ser Ser Leu Glu Leu Phe Leu Ser Cys Ala Gln Lys Gln Leu Ser Ala
 385                 390                 395                 400
 Leu Ile Ala Thr Glu Pro Val Asp Ile Glu
                 405                 410



      <210> 451
      <211> 852
      <212> PRT
      <213> Homo sapiens


      <400> 451
 Met Lys Pro Met Leu Lys Asp Phe Ser Asn Leu Leu Leu Val Val Leu
   1               5                  10                  15    
 Cys Asp Tyr Val Leu Gly Glu Ala Glu Tyr Leu Leu Leu Arg Glu Pro
              20                  25                  30        
 Gly His Val Ala Leu Ser Asn Asp Thr Gly Tyr Val Asp Phe Gln Tyr
          35                  40                  45            
 Phe Asp Gly Ala Asn Gly Thr Leu Arg Asn Val Ser Val Leu Leu Leu
      50                  55                  60                
 Glu Ala Asn Thr Asn Gln Thr Val Thr Thr Lys Tyr Leu Leu Thr Asn
  65                  70                  75                  80
 Gln Ser Gln Gly Thr Leu Lys Phe Glu Cys Phe Tyr Phe Lys Glu Ala
                  85                  90                  95    
 Gly Asp Tyr Trp Phe Thr Met Thr Pro Glu Ala Thr Asp Asn Ser Thr
             100                 105                 110        
 Pro Phe Pro Trp Trp Glu Lys Ser Ala Phe Leu Lys Val Glu Trp Pro
         115                 120                 125            
 Val Phe His Val Asp Leu Asn Arg Ser Ala Lys Ala Ala Glu Gly Thr
     130                 135                 140                
 Phe Gln Val Gly Leu Phe Thr Ser Gln Pro Leu Cys Pro Phe Pro Val
 145                 150                 155                 160
 Asp Lys Pro Asn Ile Val Val Asp Val Ile Phe Thr Asn Ser Leu Pro
                 165                 170                 175    
 Glu Ala Arg Arg Asn Ser Arg Gln Pro Leu Glu Ile Arg Thr Ser Lys
             180                 185                 190        
 Arg Thr Glu Leu Ala Gln Gly Gln Trp Val Glu Phe Gly Cys Ala Pro
         195                 200                 205            
 Leu Gly Pro Glu Ala Tyr Val Thr Val Val Leu Lys Leu Leu Gly Arg
     210                 215                 220                
 Asp Ser Val Ile Thr Ser Thr Gly Pro Ile Asp Leu Ala Gln Lys Phe
 225                 230                 235                 240
 Gly Tyr Lys Leu Val Met Val Pro Glu Leu Thr Cys Glu Ser Gly Val
                 245                 250                 255    
 Glu Val Thr Val Leu Pro Pro Pro Cys Thr Phe Val Gln Gly Val Val
             260                 265                 270        
 Thr Val Phe Lys Glu Ala Pro Arg Tyr Pro Gly Lys Arg Thr Ile His
         275                 280                 285            
 Leu Ala Lys Asn Ser Leu Pro Leu Gly Glu Arg Arg Thr Ile Phe Asn
     290                 295                 300                
 Cys Thr Leu Phe Asp Met Gly Lys Asn Lys Tyr Cys Phe Asp Phe Gly
 305                 310                 315                 320
 Ile Ser Ser Arg Ser His Phe Ser Ala Lys Glu Glu Cys Met Leu Ile
                 325                 330                 335    
 Gln Arg Asn Thr Glu Thr Trp Gly Leu Trp Gln Pro Trp Ser Gln Cys
             340                 345                 350        
 Ser Ala Thr Cys Gly Asp Gly Val Arg Glu Arg Arg Arg Val Cys Leu
         355                 360                 365            
 Thr Ser Phe Pro Ser Ser Pro Val Cys Pro Gly Met Ser Leu Glu Ala
     370                 375                 380                
 Ser Leu Cys Ser Leu Glu Glu Cys Ala Ala Phe Gln Pro Ser Ser Pro
 385                 390                 395                 400
 Ser Pro Leu Gln Pro Gln Gly Pro Val Lys Ser Asn Asn Ile Val Thr
                 405                 410                 415    
 Val Thr Gly Ile Ser Leu Cys Leu Phe Ile Ile Ile Ala Thr Val Leu
             420                 425                 430        
 Ile Thr Leu Trp Arg Arg Phe Gly Arg Pro Ala Lys Cys Ser Thr Pro
         435                 440                 445            
 Ala Arg His Asn Ser Ile His Ser Pro Ser Phe Arg Lys Asn Ser Asp
     450                 455                 460                
 Glu Glu Asn Ile Cys Glu Leu Ser Glu Gln Arg Gly Ser Phe Ser Asp
 465                 470                 475                 480
 Gly Gly Asp Gly Pro Thr Gly Ser Pro Gly Asp Thr Gly Ile Pro Leu
                 485                 490                 495    
 Thr Tyr Arg Arg Ser Gly Pro Val Pro Pro Glu Asp Asp Ala Ser Gly
             500                 505                 510        
 Ser Glu Ser Phe Gln Ser Asn Ala Gln Lys Ile Ile Pro Pro Leu Phe
         515                 520                 525            
 Ser Tyr Arg Leu Ala Gln Gln Gln Leu Lys Glu Met Lys Lys Lys Gly
     530                 535                 540                
 Leu Thr Glu Thr Thr Lys Val Tyr His Val Ser Gln Ser Pro Leu Thr
 545                 550                 555                 560
 Asp Thr Ala Ile Asp Ala Ala Pro Ser Ala Pro Leu Asp Leu Glu Ser
                 565                 570                 575    
 Pro Glu Glu Ala Ala Ala Asn Lys Phe Arg Ile Lys Ser Pro Phe Pro
             580                 585                 590        
 Glu Gln Pro Ala Val Ser Ala Gly Glu Arg Pro Pro Ser Arg Leu Asp
         595                 600                 605            
 Leu Asn Val Thr Gln Ala Ser Cys Ala Ile Ser Pro Ser Gln Thr Leu
     610                 615                 620                
 Ile Arg Lys Ser Gln Ala Arg His Val Gly Ser Arg Gly Gly Pro Ser
 625                 630                 635                 640
 Glu Arg Ser His Ala Arg Asn Ala His Phe Arg Arg Thr Ala Ser Phe
                 645                 650                 655    
 His Glu Ala Arg Gln Ala Arg Pro Phe Arg Glu Arg Ser Met Ser Thr
             660                 665                 670        
 Leu Thr Pro Arg Gln Ala Pro Ala Tyr Ser Ser Arg Thr Arg Thr Cys
         675                 680                 685            
 Glu Gln Ala Glu Asp Arg Phe Arg Pro Gln Ser Arg Gly Ala His Leu
     690                 695                 700                
 Phe Pro Glu Lys Leu Glu His Phe Gln Glu Ala Ser Gly Thr Arg Gly
 705                 710                 715                 720
 Pro Leu Asn Pro Leu Pro Lys Ser Tyr Thr Leu Gly Gln Pro Leu Arg
                 725                 730                 735    
 Lys Pro Asp Leu Gly Asp His Gln Ala Gly Leu Val Ala Gly Ile Glu
             740                 745                 750        
 Arg Thr Glu Pro His Arg Ala Arg Arg Gly Pro Ser Pro Ser His Lys
         755                 760                 765            
 Ser Val Ser Arg Lys Gln Ser Ser Pro Ile Ser Pro Lys Asp Asn Tyr
     770                 775                 780                
 Gln Arg Val Ser Ser Leu Ser Pro Ser Gln Cys Arg Lys Asp Lys Cys
 785                 790                 795                 800
 Gln Ser Phe Pro Thr His Pro Glu Phe Ala Phe Tyr Asp Asn Thr Ser
                 805                 810                 815    
 Phe Gly Leu Thr Glu Ala Glu Gln Arg Met Leu Asp Leu Pro Gly Tyr
             820                 825                 830        
 Phe Gly Ser Asn Glu Glu Asp Glu Thr Thr Ser Thr Leu Ser Val Glu
         835                 840                 845            
 Lys Leu Val Ile
     850        



      <210> 452
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 452
 Met Ser Arg Arg Tyr Asp Ser Arg Thr Thr Ile Phe Ser Pro Glu Gly
   1               5                  10                  15    
 Arg Leu Tyr Gln Val Glu Tyr Ala Met Glu Ala Ile Gly His Ala Gly
              20                  25                  30        
 Thr Cys Leu Gly Ile Leu Ala Asn Asp Gly Val Leu Leu Ala Ala Glu
          35                  40                  45            
 Arg Arg Asn Ile His Lys Leu Leu Asp Glu Val Phe Phe Ser Glu Lys
      50                  55                  60                
 Ile Tyr Lys Leu Asn Glu Asp Met Ala Cys Ser Val Ala Gly Ile Thr
  65                  70                  75                  80
 Ser Asp Ala Asn Val Leu Thr Asn Glu Leu Arg Leu Ile Ala Gln Arg
                  85                  90                  95    
 Tyr Leu Leu Gln Tyr Gln Glu Pro Ile Pro Cys Glu Gln Leu Val Thr
             100                 105                 110        
 Ala Leu Cys Asp Ile Lys Gln Ala Tyr Thr Gln Phe Gly Gly Lys Arg
         115                 120                 125            
 Pro Phe Gly Val Ser Leu Leu Tyr Ile Gly Trp Asp Lys His Tyr Gly
     130                 135                 140                
 Phe Gln Leu Tyr Gln Ser Asp Pro Ser Gly Asn Tyr Gly Gly Trp Lys
 145                 150                 155                 160
 Ala Thr Cys Ile Gly Asn Asn Ser Ala Ala Ala Val Ser Met Leu Lys
                 165                 170                 175    
 Gln Asp Tyr Lys Glu Gly Glu Met Thr Leu Lys Ser Ala Leu Ala Leu
             180                 185                 190        
 Ala Ile Lys Val Leu Asn Lys Thr Met Asp Val Ser Lys Leu Ser Ala
         195                 200                 205            
 Glu Lys Val Glu Ile Ala Thr Leu Thr Arg Glu Asn Gly Lys Thr Val
     210                 215                 220                
 Ile Arg Val Leu Lys Gln Lys Glu Val Glu Gln Leu Ile Lys Lys His
 225                 230                 235                 240
 Glu Glu Glu Glu Ala Lys Ala Glu Arg Glu Lys Lys Glu Lys Glu Gln
                 245                 250                 255    
 Lys Glu Lys Asp Lys
             260    



      <210> 453
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 453
 Met Ser Arg Arg Tyr Asp Ser Arg Thr Thr Ile Phe Ser Pro Glu Ala
   1               5                  10                  15    
 Glu Arg Arg Asn Ile His Lys Leu Leu Asp Glu Val Phe Phe Ser Glu
              20                  25                  30        
 Lys Ile Tyr Lys Leu Asn Glu Asp Met Ala Cys Ser Val Ala Gly Ile
          35                  40                  45            
 Thr Ser Asp Ala Asn Val Leu Thr Asn Glu Leu Arg Leu Ile Ala Gln
      50                  55                  60                
 Arg Tyr Leu Leu Gln Tyr Gln Glu Pro Ile Pro Cys Glu Gln Leu Val
  65                  70                  75                  80
 Thr Ala Leu Cys Asp Ile Lys Gln Ala Tyr Thr Gln Phe Gly Gly Lys
                  85                  90                  95    
 Arg Pro Phe Gly Val Ser Leu Leu Tyr Ile Gly Trp Asp Lys His Tyr
             100                 105                 110        
 Gly Phe Gln Leu Tyr Gln Ser Asp Pro Ser Gly Asn Tyr Gly Gly Trp
         115                 120                 125            
 Lys Ala Thr Cys Ile Gly Asn Asn Ser Ala Ala Ala Val Ser Met Leu
     130                 135                 140                
 Lys Gln Asp Tyr Lys Glu Gly Glu Met Thr Leu Lys Ser Ala Leu Ala
 145                 150                 155                 160
 Leu Ala Ile Lys Val Leu Asn Lys Thr Met Asp Val Ser Lys Leu Ser
                 165                 170                 175    
 Ala Glu Lys Val Glu Ile Ala Thr Leu Thr Arg Glu Asn Gly Lys Thr
             180                 185                 190        
 Val Ile Arg Val Leu Lys Gln Lys Glu Val Glu Gln Leu Ile Lys Lys
         195                 200                 205            
 His Glu Glu Glu Glu Ala Lys Ala Glu Arg Glu Lys Lys Glu Lys Glu
     210                 215                 220                
 Gln Lys Glu Lys Asp Lys
 225                 230



      <210> 454
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 454
 Met Glu Phe Asp Cys Glu Gly Leu Arg Arg Leu Leu Gly Lys Tyr Lys
   1               5                  10                  15    
 Phe Arg Asp Leu Thr Val Glu Glu Leu Arg Asn Val Asn Val Phe Phe
              20                  25                  30        
 Pro His Phe Lys Tyr Ser Met Asp Thr Tyr Val Phe Lys Asp Ser Ser
          35                  40                  45            
 Gln Lys Asp Leu Leu Asn Phe Thr Gly Thr Ile Pro Val Met Tyr Gln
      50                  55                  60                
 Gly Asn Thr Tyr Asn Ile Pro Ile Arg Phe Trp Ile Leu Asp Ser His
  65                  70                  75                  80
 Pro Phe Ala Pro Pro Ile Cys Phe Leu Lys Pro Thr Ala Asn Met Gly
                  85                  90                  95    
 Ile Leu Val Gly Lys His Val Asp Ala Gln Gly Arg Ile Tyr Leu Pro
             100                 105                 110        
 Tyr Leu Gln Asn Trp Ser His Pro Lys Ser Val Ile Val Gly Leu Ile
         115                 120                 125            
 Lys Glu Met Ile Ala Lys Phe Gln Glu Glu Leu Pro Met Tyr Ser Leu
     130                 135                 140                
 Ser Ser Ser Asp Glu Ala Arg Gln Val Asp Leu Leu Ala Tyr Ile Ala
 145                 150                 155                 160
 Lys Ile Thr Glu Gly Val Ser Asp Thr Asn Ser Lys Ser Trp Ala Asn
                 165                 170                 175    
 His Glu Asn Lys Thr Val Asn Lys Ile Thr Val Val Gly Gly Gly Glu
             180                 185                 190        
 Leu Gly Ile Ala Cys Thr Leu Ala Ile Ser Ala Lys Gly Ile Ala Asp
         195                 200                 205            
 Arg Leu Val Leu Leu Asp Leu Ser Glu Gly Thr Lys Gly Ala Thr Met
     210                 215                 220                
 Asp Leu Glu Ile Phe Asn Leu Pro Asn Val Glu Ile Ser Lys Asp Leu
 225                 230                 235                 240
 Ser Ala Ser Ala His Ser Lys Val Val Ile Phe Thr Val Asn Ser Leu
                 245                 250                 255    
 Gly Ser Ser Gln Ser Tyr Leu Asp Val Val Gln Ser Asn Val Asp Met
             260                 265                 270        
 Phe Arg Ala Leu Val Pro Ala Leu Gly His Tyr Ser Gln His Ser Val
         275                 280                 285            
 Leu Leu Val Ala Ser Gln Pro Val Glu Ile Met Thr Tyr Val Thr Trp
     290                 295                 300                
 Lys Leu Ser Thr Phe Pro Ala Asn Arg Val Ile Gly Ile Gly Cys Asn
 305                 310                 315                 320
 Leu Asp Ser Gln Arg Leu Gln Tyr Ile Ile Thr Asn Val Leu Lys Ala
                 325                 330                 335    
 Gln Thr Ser Gly Lys Glu Val Trp Val Ile Gly Glu Gln Gly Glu Asp
             340                 345                 350        
 Lys Val Leu Thr Trp Ser Gly Gln Glu Glu Val Val Ser Leu Thr Ser
         355                 360                 365            
 Gln Val Gln Leu Ser Asn Arg Asp Ile Met Ile
     370                 375                



      <210> 455
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 455
 Met Gly Gly Gly Glu Arg Tyr Asn Ile Pro Ala Pro Gln Ser Arg Asn
   1               5                  10                  15    
 Val Ser Lys Asn Gln Gln Gln Leu Asn Arg Gln Lys Thr Lys Glu Gln
              20                  25                  30        
 Asn Ser Gln Met Lys Ile Val His Lys Lys Lys Glu Arg Gly His Gly
          35                  40                  45            
 Tyr Asn Ser Ser Ala Ala Ala Trp Gln Ala Met Gln Asn Gly Gly Lys
      50                  55                  60                
 Asn Lys Asn Phe Pro Asn Asn Gln Ser Trp Asn Ser Ser Leu Ser Gly
  65                  70                  75                  80
 Pro Arg Leu Leu Phe Lys Ser Gln Ala Asn Gln Asn Tyr Ala Gly Ala
                  85                  90                  95    
 Lys Phe Ser Glu Pro Pro Ser Pro Ser Val Leu Pro Lys Pro Pro Ser
             100                 105                 110        
 His Trp Val Pro Val Ser Phe Asn Pro Ser Asp Lys Glu Ile Met Thr
         115                 120                 125            
 Phe Gln Leu Lys Thr Leu Leu Lys Val Gln Val
     130                 135                



      <210> 456
      <211> 499
      <212> PRT
      <213> Homo sapiens


      <400> 456
 Met Trp Cys Pro Pro Pro Thr Ser Val Cys Val Cys Phe Gln Arg Leu
   1               5                  10                  15    
 Pro Thr Gly Gly Asp Ala Pro Gln Glu His Gly Ala Ala Leu Pro Pro
              20                  25                  30        
 Asn Val Gln Ile Ile Pro Val Phe Val Thr Lys Glu Glu Ala Ile Ser
          35                  40                  45            
 Leu His Glu Phe Pro Val Glu Gln Met Thr Arg Ser Leu Ala Ser Pro
      50                  55                  60                
 Ala Gly Leu Gln Asp Gly Ser Ala Gln His His Pro Lys Gly Gly Ser
  65                  70                  75                  80
 Thr Ser Ala Leu Lys Glu Asn Ala Thr Gly His Val Glu Ser Met Ala
                  85                  90                  95    
 Trp Thr Thr Pro Asp Pro Thr Ser Pro Asp Glu Ala Cys Pro Asp Gly
             100                 105                 110        
 Arg Lys Glu Asn Gly Cys Leu Ser Gly His Asp Leu Glu Ser Ile Arg
         115                 120                 125            
 Pro Ala Gly Leu His Asn Ser Ala Arg Gly Glu Val Leu Gly Leu Ser
     130                 135                 140                
 Ser Ser Leu Gly Lys Glu Leu Val Phe Leu Gln Glu Glu Leu Asp Leu
 145                 150                 155                 160
 Ser Glu Ile His Ile Pro Glu Ala Gln Glu Val Glu Met Ala Ser Gly
                 165                 170                 175    
 His Phe Ala Phe Leu His Val Pro Val Pro Asp Gly Arg Ala Pro Tyr
             180                 185                 190        
 Cys Lys Ala Ser Leu Ser Ala Ser Ser Ser Leu Glu Pro Thr Pro Pro
         195                 200                 205            
 Glu Asp Thr Ala Ile Ser Ser Leu Arg Pro Pro Ser Ala Pro Glu Met
     210                 215                 220                
 Leu Thr Gln His Gly Ala Gln Glu Gln Leu Glu Asp His Pro Gly His
 225                 230                 235                 240
 Ser Ser Gln Ala Pro Ile Pro Arg Ala Asp Pro Leu Pro Arg Arg Thr
                 245                 250                 255    
 Arg Arg Pro Leu Leu Leu Pro Arg Leu Asp Pro Gly Gln Arg Gly Asn
             260                 265                 270        
 Lys Leu Pro Thr Gly Glu Gln Gly Leu Asp Glu Asp Val Asp Gly Val
         275                 280                 285            
 Cys Glu Ser His Ala Ala Pro Gly Leu Glu Cys Ser Ser Gly Ser Ala
     290                 295                 300                
 Asn Cys Gln Gly Ala Gly Pro Ser Ala Asp Gly Ile Ser Ser Arg Leu
 305                 310                 315                 320
 Thr Pro Ala Glu Ser Cys Met Gly Leu Val Arg Met Asn Leu Tyr Thr
                 325                 330                 335    
 His Cys Val Lys Gly Leu Met Leu Ser Leu Leu Ala Glu Glu Pro Leu
             340                 345                 350        
 Leu Gly Asp Ser Ala Ala Ile Glu Glu Val Tyr His Ser Ser Leu Ala
         355                 360                 365            
 Ser Leu Asn Gly Leu Glu Val His Leu Lys Glu Thr Leu Pro Arg Asp
     370                 375                 380                
 Glu Ala Ala Ser Thr Ser Ser Thr Tyr Asn Phe Thr Tyr Tyr Asp Arg
 385                 390                 395                 400
 Ile Gln Ser Leu Leu Met Ala Asn Leu Pro Gln Val Ala Thr Pro His
                 405                 410                 415    
 Asp Arg Arg Phe Leu Gln Ala Val Ser Leu Met His Ser Glu Phe Ala
             420                 425                 430        
 Gln Leu Pro Ala Leu Tyr Glu Met Thr Val Arg Asn Ala Ser Thr Ala
         435                 440                 445            
 Val Tyr Ala Cys Cys Asn Pro Ile Gln Glu Thr Tyr Phe Gln Gln Leu
     450                 455                 460                
 Ala Pro Ala Ala Arg Ser Ser Gly Phe Pro Asn Pro Gln Asp Gly Ala
 465                 470                 475                 480
 Phe Ser Leu Ser Gly Lys Ala Lys Gln Lys Leu Leu Lys His Gly Val
                 485                 490                 495    
 Asn Leu Leu
            



      <210> 457
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 457
 Met Ala Lys Val Ser Val Leu Asn Val Ala Val Leu Glu Asn Pro Ser
   1               5                  10                  15    
 Pro Phe His Ser Pro Phe Arg Phe Glu Ile Ser Phe Glu Cys Ser Glu
              20                  25                  30        
 Ala Leu Ala Asp Asp Leu Glu Trp Lys Ile Ile Tyr Val Gly Ser Ala
          35                  40                  45            
 Glu Ser Glu Glu Phe Asp Gln Ile Leu Asp Ser Val Leu Val Gly Pro
      50                  55                  60                
 Val Pro Ala Gly Arg His Met Phe Val Phe Gln Ala Asp Ala Pro Asn
  65                  70                  75                  80
 Pro Ser Leu Ile Pro Glu Ala Asp Ala Val Gly Val Thr Val Val Leu
                  85                  90                  95    
 Ile Thr Cys Thr Tyr His Gly Gln Glu Phe Ile Arg Val Gly Tyr Tyr
             100                 105                 110        
 Val Asn Asn Glu Tyr Leu Asn Pro Glu Leu Arg Glu Asn Pro Pro Met
         115                 120                 125            
 Lys Pro Asp Phe Ser Gln Leu Gln Arg Asn Ile Leu Ala Ser Asn Pro
     130                 135                 140                
 Arg Val Thr Arg Phe His Ile Asn Trp Asp Asn Asn Met Asp Arg Leu
 145                 150                 155                 160
 Glu Ala Ile Glu Thr Gln Asp Pro Ser Leu Gly Cys Gly Leu Pro Leu
                 165                 170                 175    
 Asn Cys Thr Pro Ile Lys Gly Leu Gly Leu Pro Gly Cys Ile Pro Gly
             180                 185                 190        
 Leu Leu Pro Glu Asn Ser Met Asp Cys Ile
         195                 200        



      <210> 458
      <211> 222
      <212> PRT
      <213> Homo sapiens


      <400> 458
 Met Ser Gly Leu Gly Arg Leu Phe Gly Lys Gly Lys Lys Glu Lys Gly
   1               5                  10                  15    
 Pro Thr Pro Glu Glu Ala Ile Gln Lys Leu Lys Glu Thr Glu Lys Ile
              20                  25                  30        
 Leu Ile Lys Lys Gln Glu Phe Leu Glu Gln Lys Ile Gln Gln Glu Leu
          35                  40                  45            
 Gln Thr Ala Lys Lys Tyr Gly Thr Lys Asn Lys Arg Ala Ala Leu Gln
      50                  55                  60                
 Ala Leu Arg Arg Lys Lys Arg Phe Glu Gln Gln Leu Ala Gln Thr Asp
  65                  70                  75                  80
 Gly Thr Leu Ser Thr Leu Glu Phe Gln Arg Glu Ala Ile Glu Asn Ala
                  85                  90                  95    
 Thr Thr Asn Ala Glu Val Leu Arg Thr Met Glu Leu Ala Ala Gln Ser
             100                 105                 110        
 Met Lys Lys Ala Tyr Gln Asp Met Asp Ile Asp Lys Val Asp Glu Leu
         115                 120                 125            
 Met Thr Asp Ile Thr Glu Gln Gln Glu Val Ala Gln Gln Ile Ser Asp
     130                 135                 140                
 Ala Ile Ser Arg Pro Met Gly Phe Gly Asp Asp Val Asp Glu Asp Glu
 145                 150                 155                 160
 Leu Leu Glu Glu Leu Glu Glu Leu Glu Gln Glu Glu Leu Ala Gln Glu
                 165                 170                 175    
 Leu Leu Asn Val Gly Asp Lys Glu Glu Glu Pro Ser Val Lys Leu Pro
             180                 185                 190        
 Ser Val Pro Ser Thr His Leu Pro Ala Gly Pro Ala Pro Lys Val Asp
         195                 200                 205            
 Glu Asp Glu Glu Ala Leu Lys Gln Leu Ala Glu Trp Val Ser
     210                 215                 220        



      <210> 459
      <211> 446
      <212> PRT
      <213> Homo sapiens


      <400> 459
 Met Lys Arg Gln Ala Ala Glu Glu Ala Cys Ile Leu Arg Gly Gly Ala
   1               5                  10                  15    
 Leu Ser Thr Val Arg Ala Gly Ala Glu Leu Arg Ala Val Leu Ala Leu
              20                  25                  30        
 Leu Arg Ala Gly Pro Gly Pro Gly Gly Gly Ser Lys Asp Leu Leu Phe
          35                  40                  45            
 Trp Val Ala Leu Glu Arg Arg Arg Ser His Cys Thr Leu Glu Asn Glu
      50                  55                  60                
 Pro Leu Arg Gly Phe Ser Trp Leu Ser Ser Asp Pro Gly Gly Leu Glu
  65                  70                  75                  80
 Ser Asp Thr Leu Gln Trp Val Glu Glu Pro Gln Arg Ser Cys Thr Ala
                  85                  90                  95    
 Arg Arg Cys Ala Val Leu Gln Ala Thr Gly Gly Val Glu Pro Ala Gly
             100                 105                 110        
 Trp Lys Glu Met Arg Cys His Leu Arg Ala Asn Gly Tyr Leu Cys Lys
         115                 120                 125            
 Tyr Gln Phe Glu Val Leu Cys Pro Ala Pro Arg Pro Gly Ala Ala Ser
     130                 135                 140                
 Asn Leu Ser Tyr Arg Ala Pro Phe Gln Leu His Ser Ala Ala Leu Asp
 145                 150                 155                 160
 Phe Ser Pro Pro Gly Thr Glu Val Ser Ala Leu Cys Arg Gly Gln Leu
                 165                 170                 175    
 Pro Ile Ser Val Thr Cys Ile Ala Asp Glu Ile Gly Ala Arg Trp Asp
             180                 185                 190        
 Lys Leu Ser Gly Asp Val Leu Cys Pro Cys Pro Gly Arg Tyr Leu Arg
         195                 200                 205            
 Ala Gly Lys Cys Ala Glu Leu Pro Asn Cys Leu Asp Asp Leu Gly Gly
     210                 215                 220                
 Phe Ala Cys Glu Cys Ala Thr Gly Phe Glu Leu Gly Lys Asp Gly Arg
 225                 230                 235                 240
 Ser Cys Val Thr Ser Gly Glu Gly Gln Pro Thr Leu Gly Gly Thr Gly
                 245                 250                 255    
 Val Pro Thr Arg Arg Pro Pro Ala Thr Ala Thr Ser Pro Val Pro Gln
             260                 265                 270        
 Arg Thr Trp Pro Ile Arg Val Asp Glu Lys Leu Gly Glu Thr Pro Leu
         275                 280                 285            
 Val Pro Glu Gln Asp Asn Ser Val Thr Ser Ile Pro Glu Ile Pro Arg
     290                 295                 300                
 Trp Gly Ser Gln Ser Thr Met Ser Thr Leu Gln Met Ser Leu Gln Ala
 305                 310                 315                 320
 Glu Ser Lys Ala Thr Ile Thr Pro Ser Gly Ser Val Ile Ser Lys Phe
                 325                 330                 335    
 Asn Ser Thr Thr Ser Ser Ala Thr Pro Gln Ala Phe Asp Ser Ser Ser
             340                 345                 350        
 Ala Val Val Phe Ile Phe Val Ser Thr Ala Val Val Val Leu Val Ile
         355                 360                 365            
 Leu Thr Met Thr Val Leu Gly Leu Val Lys Leu Cys Phe His Glu Ser
     370                 375                 380                
 Pro Ser Ser Gln Pro Arg Lys Glu Ser Met Gly Pro Pro Gly Leu Glu
 385                 390                 395                 400
 Ser Asp Pro Glu Pro Ala Ala Leu Gly Ser Ser Ser Ala His Cys Thr
                 405                 410                 415    
 Asn Asn Gly Val Lys Val Gly Asp Cys Asp Leu Arg Asp Arg Ala Glu
             420                 425                 430        
 Gly Ala Leu Leu Ala Glu Ser Pro Leu Gly Ser Ser Asp Ala
         435                 440                 445    



      <210> 460
      <211> 618
      <212> PRT
      <213> Homo sapiens


      <400> 460
 Met Glu Asn Phe Ile Leu Tyr Glu Glu Ile Gly Arg Gly Ser Lys Thr
   1               5                  10                  15    
 Val Val Tyr Lys Gly Arg Arg Lys Gly Thr Ile Asn Phe Val Ala Ile
              20                  25                  30        
 Leu Cys Thr Asp Lys Cys Lys Arg Pro Glu Ile Thr Asn Trp Val Arg
          35                  40                  45            
 Leu Thr Arg Glu Ile Lys His Lys Asn Ile Val Thr Phe His Glu Trp
      50                  55                  60                
 Tyr Glu Thr Ser Asn His Leu Trp Leu Val Val Glu Leu Cys Thr Gly
  65                  70                  75                  80
 Gly Ser Leu Lys Thr Val Ile Ala Gln Asp Glu Asn Leu Pro Glu Asp
                  85                  90                  95    
 Val Val Arg Glu Phe Gly Ile Asp Leu Ile Ser Gly Leu His His Leu
             100                 105                 110        
 His Lys Leu Gly Ile Leu Phe Cys Asp Ile Ser Pro Arg Lys Ile Leu
         115                 120                 125            
 Leu Glu Gly Pro Gly Thr Leu Lys Phe Ser Asn Phe Cys Leu Ala Lys
     130                 135                 140                
 Val Glu Gly Glu Asn Leu Glu Glu Phe Phe Ala Leu Val Ala Ala Glu
 145                 150                 155                 160
 Glu Gly Gly Gly Asp Asn Gly Glu Asn Val Leu Lys Lys Ser Met Lys
                 165                 170                 175    
 Ser Arg Val Lys Gly Ser Pro Val Tyr Thr Ala Pro Glu Val Val Arg
             180                 185                 190        
 Gly Ala Asp Phe Ser Ile Ser Ser Asp Leu Trp Ser Leu Gly Cys Leu
         195                 200                 205            
 Leu Tyr Glu Met Phe Ser Gly Lys Pro Pro Phe Phe Ser Glu Ser Ile
     210                 215                 220                
 Ser Glu Leu Thr Glu Lys Ile Leu Cys Glu Asp Pro Leu Pro Pro Ile
 225                 230                 235                 240
 Pro Lys Asp Ser Ser Arg Pro Lys Ala Ser Ser Asp Phe Ile Asn Leu
                 245                 250                 255    
 Leu Asp Gly Leu Leu Gln Arg Asp Pro Gln Lys Arg Leu Thr Trp Thr
             260                 265                 270        
 Arg Leu Leu Gln His Ser Phe Trp Lys Lys Ala Phe Ala Gly Ala Asp
         275                 280                 285            
 Gln Glu Ser Ser Val Glu Asp Leu Ser Leu Ser Arg Asn Thr Met Glu
     290                 295                 300                
 Cys Ser Gly Pro Gln Asp Ser Lys Glu Leu Leu Gln Asn Ser Gln Ser
 305                 310                 315                 320
 Arg Gln Ala Lys Gly His Lys Ser Gly Gln Pro Leu Gly His Ser Phe
                 325                 330                 335    
 Arg Leu Glu Asn Pro Thr Glu Phe Arg Pro Lys Ser Thr Leu Glu Gly
             340                 345                 350        
 Gln Leu Asn Glu Ser Met Phe Leu Leu Ser Ser Arg Pro Thr Pro Arg
         355                 360                 365            
 Thr Ser Thr Ala Val Glu Val Ser Pro Gly Glu Asp Met Thr His Cys
     370                 375                 380                
 Ser Pro Gln Lys Thr Ser Pro Leu Thr Lys Ile Thr Ser Gly His Leu
 385                 390                 395                 400
 Ser Gln Gln Asp Leu Glu Ser Gln Met Arg Glu Leu Ile Tyr Thr Asp
                 405                 410                 415    
 Ser Asp Leu Val Val Thr Pro Ile Ile Asp Asn Pro Lys Ile Met Lys
             420                 425                 430        
 Gln Pro Pro Val Lys Phe Asp Ala Lys Ile Leu His Leu Pro Thr Tyr
         435                 440                 445            
 Ser Val Asp Lys Leu Leu Phe Leu Lys Asp Gln Asp Trp Asn Asp Phe
     450                 455                 460                
 Leu Gln Gln Val Cys Ser Gln Ile Asp Ser Thr Glu Lys Ser Met Gly
 465                 470                 475                 480
 Ala Ser Arg Ala Lys Leu Asn Leu Leu Cys Tyr Leu Cys Val Val Ala
                 485                 490                 495    
 Gly His Gln Glu Val Ala Thr Arg Leu Leu His Ser Pro Leu Phe Gln
             500                 505                 510        
 Leu Leu Ile Gln His Leu Arg Ile Ala Pro Asn Trp Asp Ile Arg Ala
         515                 520                 525            
 Lys Val Ala His Val Ile Gly Leu Leu Ala Ser His Thr Ala Glu Leu
     530                 535                 540                
 Gln Glu Asn Thr Pro Val Val Glu Ala Ile Val Leu Leu Thr Glu Leu
 545                 550                 555                 560
 Ile Arg Glu Asn Phe Arg Asn Ser Lys Leu Lys Gln Cys Leu Leu Pro
                 565                 570                 575    
 Thr Leu Gly Glu Leu Ile Tyr Leu Val Ala Pro Gln Glu Glu Lys Lys
             580                 585                 590        
 Lys Asn Pro Arg Glu Cys Trp Ala Val Pro Leu Ala Ala Tyr Thr Val
         595                 600                 605            
 Leu Met Arg Cys Leu Arg Glu Gly Glu Leu
     610                 615            



      <210> 461
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 461
 Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala
   1               5                  10                  15    
 Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn
              20                  25                  30        
 Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser
          35                  40                  45            
 Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser
      50                  55                  60                
 Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser
  65                  70                  75                  80
 Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp
                  85                  90                  95    
 Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu
             100                 105                 110        
 Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg
         115                 120                 125            
 Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu
     130                 135                 140                
 Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser
 145                 150                 155                 160
 Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg
                 165                 170                 175    
 Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser
             180                 185                 190        
 Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser
         195                 200                 205            
 Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn
     210                 215                 220                
 Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp
 225                 230                 235                 240
 Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp
                 245                 250            



      <210> 462
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 462
 Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu
   1               5                  10                  15    
 Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu
              20                  25                  30        
 Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys
          35                  40                  45            
 Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser
      50                  55                  60                
 Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe
  65                  70                  75                  80
 Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val
                  85                  90                  95    
 Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys
             100                 105                 110        
 Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu
         115                 120                 125            
 Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe
     130                 135                 140                
 Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu
 145                 150                 155                 160
 Asp Arg Arg Ser Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu
                 165                 170                 175    
 Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Thr
             180                 185                 190        
 Leu Pro Leu Gln Gln His Gln His Gln Pro Gln Pro Pro Gln Tyr Ala
         195                 200                 205            
 Pro Ala Pro Gln Gln Leu Gln Gln Pro Pro Gln Gln Arg Tyr Leu Gln
     210                 215                 220                
 His His His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp Ile Asn
 225                 230                 235                 240
 Asp Gly His Cys Gly Thr Gly Leu Gly Ser Glu Met Asn Ala Ala Leu
                 245                 250                 255    
 Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly Arg
             260                 265                 270        
 Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp Asp
         275                 280                 285            
 Glu Leu Gly Phe His Ser Gly Glu Val Val Glu Val Leu Asp Ser Ser
     290                 295                 300                
 Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu Phe
 305                 310                 315                 320
 Pro Ala Asn Tyr Val Ala Pro Met Thr Arg
                 325                 330



      <210> 463
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 463
 Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu
   1               5                  10                  15    
 Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu
              20                  25                  30        
 Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys
          35                  40                  45            
 Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser
      50                  55                  60                
 Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe
  65                  70                  75                  80
 Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val
                  85                  90                  95    
 Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys
             100                 105                 110        
 Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu
         115                 120                 125            
 Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe
     130                 135                 140                
 Leu Arg Asp Arg Thr Arg Glu Asp Gln Arg Val Arg Trp Ala Arg Ala
 145                 150                 155                 160
 Leu Tyr Asp Phe Glu Ala Leu Glu Asp Asp Glu Leu Gly Phe His Ser
                 165                 170                 175    
 Gly Glu Val Val Glu Val Leu Asp Ser Ser Asn Pro Ser Trp Trp Thr
             180                 185                 190        
 Gly Arg Leu His Asn Lys Leu Gly Leu Phe Pro Ala Asn Tyr Val Ala
         195                 200                 205            
 Pro Met Thr Arg
     210        



      <210> 464
      <211> 76
      <212> PRT
      <213> Homo sapiens


      <400> 464
 Met Ile Lys His Ala Gln Arg Ser Trp Asn Arg Tyr Ser Tyr Leu Val
   1               5                  10                  15    
 Arg Val Asn Lys Asn Asn Gln Gly Pro Arg Val Cys Met Leu Pro Gly
              20                  25                  30        
 Gly Gly Glu Arg Gly Ile Ser Gln Asn Leu Lys Thr Asn Trp Lys Asn
          35                  40                  45            
 Asn Gln Asp Ser Gln Val Lys Gln Pro Gln Gly Pro Lys Gln Ser Arg
      50                  55                  60                
 Ser Leu Met Cys Leu Glu Met Thr Leu Cys Tyr Ser
  65                  70                  75    



      <210> 465
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 465
 Met Ala Ala Ser Met His Gly Gln Pro Ser Pro Ser Leu Glu Asp Ala
   1               5                  10                  15    
 Lys Leu Arg Arg Pro Met Val Ile Glu Ile Ile Glu Lys Asn Phe Asp
              20                  25                  30        
 Tyr Leu Arg Lys Glu Met Thr Gln Asn Ile Tyr Gln Met Ala Thr Phe
          35                  40                  45            
 Gly Thr Thr Ala Gly Phe Ser Gly Ile Phe Ser Asn Phe Leu Phe Arg
      50                  55                  60                
 Arg Cys Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr Ala Ser Leu
  65                  70                  75                  80
 Ala Thr Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys Leu Phe Val
                  85                  90                  95    
 Ile Asp Ala Leu Tyr Ser Asp Asn Ile Ser Lys Glu Asn Cys Val Phe
             100                 105                 110        
 Arg Ser Ser Leu Ile Gly Ile Val Cys Gly Val Phe Tyr Pro Ser Ser
         115                 120                 125            
 Leu Ala Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr His Thr Val
     130                 135                 140                
 Pro Leu Pro Pro Lys Gly Arg Val Leu Ile His Trp Met Thr Leu Cys
 145                 150                 155                 160
 Gln Thr Gln Met Lys Leu Met Ala Ile Pro Leu Val Phe Gln Ile Met
                 165                 170                 175    
 Phe Gly Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe Glu Glu Thr
             180                 185                 190        
 Leu Glu Lys Thr Ile His Glu Glu
         195                 200



      <210> 466
      <211> 658
      <212> PRT
      <213> Homo sapiens


      <400> 466
 Met Leu Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr
   1               5                  10                  15    
 Gly Met Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys
              20                  25                  30        
 Arg Val Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val
          35                  40                  45            
 Ser Tyr Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr
      50                  55                  60                
 Ala Arg Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu
  65                  70                  75                  80
 Arg Gln Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp
                  85                  90                  95    
 Thr Gly Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu
             100                 105                 110        
 Gln Ser Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser
         115                 120                 125            
 Arg Trp Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg
     130                 135                 140                
 Gly Arg Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr
 145                 150                 155                 160
 Leu Pro Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala
                 165                 170                 175    
 Met Glu Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser
             180                 185                 190        
 Ser Thr Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser
         195                 200                 205            
 Pro His Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln
     210                 215                 220                
 Ser Val Glu Ala Ser Gly His His Thr His His Gln Ser Asp Ser Pro
 225                 230                 235                 240
 Ser Ser Val Val Asn Lys Gln Leu Gly Ser Met Ser Leu Asp Glu Gln
                 245                 250                 255    
 Gln Asp Asn Asn Asn Glu Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu
             260                 265                 270        
 Pro Val Leu Ser Leu His Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr
         275                 280                 285            
 Ile Lys Leu Asn Phe Thr Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser
     290                 295                 300                
 Arg Gly Ile Gly Ser His Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe
 305                 310                 315                 320
 Val Pro Gln Ser Ser Val Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys
                 325                 330                 335    
 Ala Pro Glu Glu Ser Ser Glu Asp Val Thr Lys Tyr Gln Glu Gly Val
             340                 345                 350        
 Ser Ala Glu Asn Pro Val Glu Asn His Ile Asn Ile Thr Gln Ser Asp
         355                 360                 365            
 Lys Phe Thr Ala Lys Pro Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp
     370                 375                 380                
 Leu Asn Leu Asp Arg Ser Cys Gly Val Pro Glu Glu Ser Ala Ser Ser
 385                 390                 395                 400
 Glu Lys Ala Lys Glu Pro Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser
                 405                 410                 415    
 Ala Thr Asn Glu Asn Asn Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu
             420                 425                 430        
 Ala Thr Gly Pro Ser Ala His Glu Glu Thr Ser Thr Arg Asp Ser Ala
         435                 440                 445            
 Leu Gln Asp Thr Asp Asp Ser Asp Asp Asp Pro Val Leu Ile Pro Gly
     450                 455                 460                
 Ala Arg Tyr Arg Ala Gly Pro Gly Asp Arg Arg Ser Ala Val Ala Arg
 465                 470                 475                 480
 Ile Gln Glu Phe Phe Arg Arg Arg Lys Glu Arg Lys Glu Met Glu Glu
                 485                 490                 495    
 Leu Asp Thr Leu Asn Ile Arg Arg Pro Leu Val Lys Met Val Tyr Lys
             500                 505                 510        
 Gly His Arg Asn Ser Arg Thr Met Ile Lys Glu Ala Asn Phe Trp Gly
         515                 520                 525            
 Ala Asn Phe Val Met Ser Gly Ser Asp Cys Gly His Ile Phe Ile Trp
     530                 535                 540                
 Asp Arg His Thr Ala Glu His Leu Met Leu Leu Glu Ala Asp Asn His
 545                 550                 555                 560
 Val Val Asn Cys Leu Gln Pro His Pro Phe Asp Pro Ile Leu Ala Ser
                 565                 570                 575    
 Ser Gly Ile Asp Tyr Asp Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser
             580                 585                 590        
 Arg Ile Phe Asn Arg Lys Leu Ala Asp Glu Val Ile Thr Arg Asn Glu
         595                 600                 605            
 Leu Met Leu Glu Glu Thr Arg Asn Thr Ile Thr Val Pro Ala Ser Phe
     610                 615                 620                
 Met Leu Arg Met Leu Ala Ser Leu Asn His Ile Arg Ala Asp Arg Leu
 625                 630                 635                 640
 Glu Gly Asp Arg Ser Glu Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp
                 645                 650                 655    
 Glu Glu
        



      <210> 467
      <211> 638
      <212> PRT
      <213> Homo sapiens


      <400> 467
 Met Leu Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr
   1               5                  10                  15    
 Gly Met Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys
              20                  25                  30        
 Arg Val Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val
          35                  40                  45            
 Ser Tyr Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr
      50                  55                  60                
 Ala Arg Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu
  65                  70                  75                  80
 Arg Gln Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp
                  85                  90                  95    
 Thr Gly Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu
             100                 105                 110        
 Gln Ser Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser
         115                 120                 125            
 Arg Trp Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg
     130                 135                 140                
 Gly Arg Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr
 145                 150                 155                 160
 Leu Pro Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala
                 165                 170                 175    
 Met Glu Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser
             180                 185                 190        
 Ser Thr Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser
         195                 200                 205            
 Pro His Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln
     210                 215                 220                
 Ser Val Glu Ala Ser Gly His His Thr His His Gln Ser Asp Asn Asn
 225                 230                 235                 240
 Asn Glu Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val Leu Ser
                 245                 250                 255    
 Leu His Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu Asn
             260                 265                 270        
 Phe Thr Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile Gly
         275                 280                 285            
 Ser His Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro Gln Ser
     290                 295                 300                
 Ser Val Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu Glu
 305                 310                 315                 320
 Ser Ser Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu Asn
                 325                 330                 335    
 Pro Val Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr Ala
             340                 345                 350        
 Lys Pro Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu Asp
         355                 360                 365            
 Arg Ser Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala Lys
     370                 375                 380                
 Glu Pro Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn Glu
 385                 390                 395                 400
 Asn Asn Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly Pro
                 405                 410                 415    
 Ser Ala His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp Thr
             420                 425                 430        
 Asp Asp Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr Arg
         435                 440                 445            
 Ala Gly Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln Glu Phe
     450                 455                 460                
 Phe Arg Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp Thr Leu
 465                 470                 475                 480
 Asn Ile Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His Arg Asn
                 485                 490                 495    
 Ser Arg Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn Phe Val
             500                 505                 510        
 Met Ser Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg His Thr
         515                 520                 525            
 Ala Glu His Leu Met Leu Leu Glu Ala Asp Asn His Val Val Asn Cys
     530                 535                 540                
 Leu Gln Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly Ile Asp
 545                 550                 555                 560
 Tyr Asp Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile Phe Asn
                 565                 570                 575    
 Arg Lys Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met Leu Glu
             580                 585                 590        
 Glu Thr Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu Arg Met
         595                 600                 605            
 Leu Ala Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly Asp Arg
     610                 615                 620                
 Ser Glu Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu
 625                 630                 635            



      <210> 468
      <211> 443
      <212> PRT
      <213> Homo sapiens


      <400> 468
 Met Thr Arg Ser Leu Ala Ser Pro Ala Gly Leu Gln Asp Gly Ser Ala
   1               5                  10                  15    
 Gln His His Pro Lys Gly Gly Ser Thr Ser Ala Leu Lys Glu Asn Ala
              20                  25                  30        
 Thr Gly His Val Glu Ser Met Ala Trp Thr Thr Pro Asp Pro Thr Ser
          35                  40                  45            
 Pro Asp Glu Ala Cys Pro Asp Gly Arg Lys Glu Asn Gly Cys Leu Ser
      50                  55                  60                
 Gly His Asp Leu Glu Ser Ile Arg Pro Ala Gly Leu His Asn Ser Ala
  65                  70                  75                  80
 Arg Gly Glu Val Leu Gly Leu Ser Ser Ser Leu Gly Lys Glu Leu Val
                  85                  90                  95    
 Phe Leu Gln Glu Glu Leu Asp Leu Ser Glu Ile His Ile Pro Glu Ala
             100                 105                 110        
 Gln Glu Val Glu Met Ala Ser Gly His Phe Ala Phe Leu His Val Pro
         115                 120                 125            
 Val Pro Asp Gly Arg Ala Pro Tyr Cys Lys Ala Ser Leu Ser Ala Ser
     130                 135                 140                
 Ser Ser Leu Glu Pro Thr Pro Pro Glu Asp Thr Ala Ile Ser Ser Leu
 145                 150                 155                 160
 Arg Pro Pro Ser Ala Pro Glu Met Leu Thr Gln His Gly Ala Gln Glu
                 165                 170                 175    
 Gln Leu Glu Asp His Pro Gly His Ser Ser Gln Ala Pro Ile Pro Arg
             180                 185                 190        
 Ala Asp Pro Leu Pro Arg Arg Thr Arg Arg Pro Leu Leu Leu Pro Arg
         195                 200                 205            
 Leu Asp Pro Gly Gln Arg Gly Asn Lys Leu Pro Thr Gly Glu Gln Gly
     210                 215                 220                
 Leu Asp Glu Asp Val Asp Gly Val Cys Glu Ser His Ala Ala Pro Gly
 225                 230                 235                 240
 Leu Glu Cys Ser Ser Gly Ser Ala Asn Cys Gln Gly Ala Gly Pro Ser
                 245                 250                 255    
 Ala Asp Gly Ile Ser Ser Arg Leu Thr Pro Ala Glu Ser Cys Met Gly
             260                 265                 270        
 Leu Val Arg Met Asn Leu Tyr Thr His Cys Val Lys Gly Leu Met Leu
         275                 280                 285            
 Ser Leu Leu Ala Glu Glu Pro Leu Leu Gly Asp Ser Ala Ala Ile Glu
     290                 295                 300                
 Glu Val Tyr His Ser Ser Leu Ala Ser Leu Asn Gly Leu Glu Val His
 305                 310                 315                 320
 Leu Lys Glu Thr Leu Pro Arg Asp Glu Ala Ala Ser Thr Ser Ser Thr
                 325                 330                 335    
 Tyr Asn Phe Thr Tyr Tyr Asp Arg Ile Gln Ser Leu Leu Met Ala Asn
             340                 345                 350        
 Leu Pro Gln Val Ala Thr Pro His Asp Arg Arg Phe Leu Gln Ala Val
         355                 360                 365            
 Ser Leu Met His Ser Glu Phe Ala Gln Leu Pro Ala Leu Tyr Glu Met
     370                 375                 380                
 Thr Val Arg Asn Ala Ser Thr Ala Val Tyr Ala Cys Cys Asn Pro Ile
 385                 390                 395                 400
 Gln Glu Thr Tyr Phe Gln Gln Leu Ala Pro Ala Ala Arg Ser Ser Gly
                 405                 410                 415    
 Phe Pro Asn Pro Gln Asp Gly Ala Phe Ser Leu Ser Gly Lys Ala Lys
             420                 425                 430        
 Gln Lys Leu Leu Lys His Gly Val Asn Leu Leu
         435                 440            



      <210> 469
      <211> 602
      <212> PRT
      <213> Homo sapiens


      <400> 469
 Met Ser Trp Leu Ser Ser Ser Gln Gly Val Val Leu Thr Ala Tyr His
   1               5                  10                  15    
 Pro Ser Gly Lys Asp Gln Ala Val Gly Asn Ser His Ala Lys Ala Gly
              20                  25                  30        
 Glu Glu Ala Thr Ser Ser Arg Arg Tyr Gly Gln Tyr Thr Met Asn Gln
          35                  40                  45            
 Glu Ser Thr Thr Ile Lys Val Met Glu Lys Pro Pro Phe Asp Arg Ser
      50                  55                  60                
 Ile Ser Gln Asp Ser Leu Asp Glu Leu Ser Met Glu Asp Tyr Trp Ile
  65                  70                  75                  80
 Glu Leu Glu Asn Ile Lys Lys Ser Ser Glu Asn Ser Gln Glu Asp Gln
                  85                  90                  95    
 Glu Val Val Val Val Lys Glu Pro Asp Glu Gly Glu Leu Glu Glu Glu
             100                 105                 110        
 Trp Leu Lys Glu Ala Gly Leu Ser Asn Leu Phe Gly Glu Ser Ala Gly
         115                 120                 125            
 Asp Pro Gln Glu Ser Ile Val Phe Leu Ser Thr Leu Thr Arg Thr Gln
     130                 135                 140                
 Ala Ala Ala Val Gln Lys Arg Val Glu Thr Val Ser Gln Thr Leu Arg
 145                 150                 155                 160
 Lys Lys Asn Lys Gln Tyr Gln Ile Pro Asp Val Arg Asp Ile Phe Ala
                 165                 170                 175    
 Gln Gln Arg Glu Ser Lys Glu Thr Ala Pro Gly Gly Thr Glu Ser Gln
             180                 185                 190        
 Ser Leu Arg Thr Asn Glu Asn Lys Tyr Gln Gly Arg Asp Asp Glu Ala
         195                 200                 205            
 Ser Asn Leu Val Gly Glu Glu Lys Leu Ile Pro Pro Glu Glu Thr Pro
     210                 215                 220                
 Ala Pro Glu Thr Asp Ile Asn Leu Glu Val Ser Phe Ala Glu Gln Ala
 225                 230                 235                 240
 Leu Asn Gln Lys Glu Ser Ser Lys Glu Lys Ile Gln Lys Ser Lys Gly
                 245                 250                 255    
 Asp Asp Ala Thr Leu Pro Ser Phe Arg Leu Pro Lys Asp Lys Thr Gly
             260                 265                 270        
 Thr Thr Arg Ile Gly Asp Leu Ala Pro Gln Asp Met Lys Lys Val Cys
         275                 280                 285            
 His Leu Ala Leu Ile Glu Leu Thr Ala Leu Tyr Asp Val Leu Gly Ile
     290                 295                 300                
 Glu Leu Lys Gln Gln Lys Ala Val Lys Ile Lys Thr Lys Asp Ser Gly
 305                 310                 315                 320
 Leu Phe Cys Val Pro Leu Thr Ala Leu Leu Glu Gln Asp Gln Arg Lys
                 325                 330                 335    
 Val Pro Gly Met Arg Ile Pro Leu Ile Phe Gln Lys Leu Ile Ser Arg
             340                 345                 350        
 Ile Glu Glu Arg Gly Leu Glu Thr Glu Gly Leu Leu Arg Ile Pro Gly
         355                 360                 365            
 Ala Ala Ile Arg Ile Lys Asn Leu Cys Gln Glu Leu Glu Ala Lys Phe
     370                 375                 380                
 Tyr Glu Gly Thr Phe Asn Trp Glu Ser Val Lys Gln His Asp Ala Ala
 385                 390                 395                 400
 Ser Leu Leu Lys Leu Phe Ile Arg Glu Leu Pro Gln Pro Leu Leu Ser
                 405                 410                 415    
 Val Glu Tyr Leu Lys Ala Phe Gln Ala Val Gln Asn Leu Pro Thr Lys
             420                 425                 430        
 Lys Gln Gln Leu Gln Ala Leu Asn Leu Leu Val Ile Leu Leu Pro Asp
         435                 440                 445            
 Ala Asn Arg Asp Thr Leu Lys Ala Leu Leu Glu Phe Leu Gln Arg Val
     450                 455                 460                
 Ile Asp Asn Lys Glu Lys Asn Lys Met Thr Val Met Asn Val Ala Met
 465                 470                 475                 480
 Val Met Ala Pro Asn Leu Phe Met Cys His Ala Leu Gly Leu Lys Ser
                 485                 490                 495    
 Ser Glu Gln Arg Glu Phe Val Met Ala Ala Gly Thr Ala Asn Thr Met
             500                 505                 510        
 His Leu Leu Ile Lys Tyr Gln Lys Leu Leu Trp Thr Ile Pro Lys Phe
         515                 520                 525            
 Ile Val Asn Gln Val Arg Lys Gln Asn Thr Glu Asn His Lys Lys Asp
     530                 535                 540                
 Lys Arg Ala Met Lys Lys Leu Leu Lys Lys Met Ala Tyr Asp Arg Glu
 545                 550                 555                 560
 Lys Tyr Glu Lys Gln Asp Lys Ser Thr Asn Asp Ala Asp Val Pro Gln
                 565                 570                 575    
 Gly Val Ile Arg Val Gln Ala Pro His Leu Ser Lys Val Ser Met Ala
             580                 585                 590        
 Ile Gln Leu Thr Glu Gly Thr Lys Ser Gln
         595                 600        



      <210> 470
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 470
 Met Ala Lys Ser Lys Val Thr Gln Pro Ser Ala Ser Glu Gln Arg Arg
   1               5                  10                  15    
 Ile Gln Val Ser Cys Pro Ser Ala Leu Ser Ala Ala His Ala Thr Cys
              20                  25                  30        
 Phe His Ala Ile Ser Val His Leu Pro Ala Thr His Leu Gln Ser Glu
          35                  40                  45            
 Thr Glu Ser Leu Arg Val Cys Val Glu Pro Lys Arg Gly Gln Gln Trp
      50                  55                  60                
 Leu Glu Ala Arg His Lys Ser Tyr Leu His Ser Arg Arg Gly Asp His
  65                  70                  75                  80
 Ala Lys Asp Lys Leu Gln Arg Asp Asn Arg Phe Ala Ser Gln Thr His
                  85                  90                  95    
 Ser His Trp Ala Lys Ser Ser Cys His Cys Arg Phe Glu Ser Arg Pro
             100                 105                 110        
 Phe Phe Leu Pro Ser Pro Ser Trp Ser Tyr Asn Arg Ser Trp Gly Gly
         115                 120                 125            
 Glu Ser Ala Glu Arg Thr Trp Met Lys Gln Arg Gly Thr Cys Leu Ser
     130                 135                 140                
 His Ser Pro Leu Asp Leu Leu His Pro Gly Leu Cys Gln His Lys Val
 145                 150                 155                 160
 Gly Ala Arg
            



      <210> 471
      <211> 551
      <212> PRT
      <213> Homo sapiens


      <400> 471
 Met Ala Leu Thr Val His Phe Glu Glu Ala Ala Thr Ala Lys Glu Arg
   1               5                  10                  15    
 Ser Lys Val Ala Lys Ile Gly Ala Phe Cys Cys Gly Leu Ser Leu Cys
              20                  25                  30        
 Asn Gln His Thr Ile Ile Leu Tyr Val Leu Cys Ile Ile Pro Trp Ile
          35                  40                  45            
 Leu Phe Gln Leu Leu Lys Lys Lys Glu Leu Ser Leu Gly Ser Leu Leu
      50                  55                  60                
 Lys Leu Ser Leu Tyr Phe Ser Ala Gly Leu Leu Pro Tyr Val His Leu
  65                  70                  75                  80
 Pro Ile Ser Ser Tyr Leu Asn His Ala Arg Trp Thr Trp Gly Asp Gln
                  85                  90                  95    
 Thr Thr Leu Gln Gly Phe Leu Thr His Phe Leu Arg Glu Glu Tyr Gly
             100                 105                 110        
 Thr Phe Ser Leu Ala Lys Ser Glu Ile Gly Ser Ser Met Ser Glu Ile
         115                 120                 125            
 Leu Leu Ser Gln Val Thr Asn Met Arg Thr Glu Leu Ser Phe Asn Ile
     130                 135                 140                
 Gln Ala Leu Ala Val Cys Ala Asn Ile Cys Leu Ala Thr Lys Asp Arg
 145                 150                 155                 160
 Gln Asn Pro Ser Leu Val Trp Leu Phe Thr Gly Met Phe Cys Ile Tyr
                 165                 170                 175    
 Ser Leu Phe Phe Ala Trp Arg Ala Asn Leu Asp Ile Ser Lys Pro Leu
             180                 185                 190        
 Phe Met Gly Val Val Glu Arg Phe Trp Met Gln Ser Asn Ala Val Val
         195                 200                 205            
 Ala Val Leu Ala Gly Ile Gly Leu Ala Ala Val Val Ser Glu Thr Asn
     210                 215                 220                
 Arg Val Leu Asn Ser Asn Gly Leu Gln Cys Leu Glu Trp Leu Ser Ala
 225                 230                 235                 240
 Thr Leu Phe Val Val Tyr Gln Ile Tyr Ser Asn Tyr Ser Val Cys Asp
                 245                 250                 255    
 Gln Arg Thr Asn Tyr Val Ile Asp Lys Phe Ala Lys Asn Leu Leu Thr
             260                 265                 270        
 Ser Met Pro His Asp Ala Ile Ile Leu Leu Arg Gly Asp Leu Pro Gly
         275                 280                 285            
 Asn Ser Leu Arg Tyr Met His Tyr Cys Glu Gly Leu Arg Pro Asp Ile
     290                 295                 300                
 Ser Leu Val Asp Gln Glu Met Met Thr Tyr Glu Trp Tyr Leu Pro Lys
 305                 310                 315                 320
 Met Ala Lys His Leu Pro Gly Val Asn Phe Pro Gly Asn Arg Trp Asn
                 325                 330                 335    
 Pro Val Glu Gly Ile Leu Pro Ser Gly Met Val Thr Phe Asn Leu Tyr
             340                 345                 350        
 His Phe Leu Glu Val Asn Lys Gln Lys Glu Thr Phe Val Cys Ile Gly
         355                 360                 365            
 Ile His Glu Gly Asp Pro Thr Trp Lys Lys Asn Tyr Ser Leu Trp Pro
     370                 375                 380                
 Trp Gly Ser Cys Asp Lys Leu Val Pro Leu Glu Ile Val Phe Asn Pro
 385                 390                 395                 400
 Glu Glu Trp Ile Lys Leu Thr Lys Asn Ile Tyr Asn Trp Thr Glu Glu
                 405                 410                 415    
 Tyr Gly Arg Phe Asp Pro Ser Ser Trp Glu Ser Val Ala Asn Glu Glu
             420                 425                 430        
 Met Trp Gln Ala Arg Met Lys Thr Pro Phe Phe Ile Phe Asn Leu Ala
         435                 440                 445            
 Glu Thr Ala His Met Pro Ser Lys Val Lys Ala Gln Leu Tyr Ala Gln
     450                 455                 460                
 Ala Tyr Asp Leu Tyr Lys Glu Ile Val Tyr Leu Gln Lys Glu His Pro
 465                 470                 475                 480
 Val Asn Trp His Lys Asn Tyr Ala Ile Ala Cys Glu Arg Met Leu Arg
                 485                 490                 495    
 Leu Gln Ala Arg Asp Ala Asp Pro Glu Val Leu Leu Ser Glu Thr Ile
             500                 505                 510        
 Arg His Phe Arg Leu Tyr Ser Gln Lys Ala Pro Asn Asp Pro Gln Gln
         515                 520                 525            
 Ala Asp Ile Leu Gly Ala Leu Lys His Leu Arg Lys Glu Leu Gln Ser
     530                 535                 540                
 Leu Arg Asn Arg Lys Asn Val
 545                 550    



      <210> 472
      <211> 914
      <212> PRT
      <213> Homo sapiens


      <400> 472
 Met Glu Asn Trp Pro Thr Pro Ser Glu Leu Val Asn Thr Gly Phe Gln
   1               5                  10                  15    
 Ser Val Leu Ser Gln Gly Asn Lys Lys Pro Gln Asn Arg Lys Glu Lys
              20                  25                  30        
 Glu Glu Lys Val Glu Lys Arg Ser Asn Ser Asp Ser Lys Glu Asn Arg
          35                  40                  45            
 Glu Thr Lys Leu Asn Gly Pro Gly Glu Asn Val Ser Glu Asp Glu Ala
      50                  55                  60                
 Gln Ser Ser Asn Gln Arg Lys Arg Ala Asn Lys His Lys Trp Val Pro
  65                  70                  75                  80
 Leu His Leu Asp Val Val Arg Ser Glu Ser Gln Glu Arg Pro Gly Ser
                  85                  90                  95    
 Arg Asn Ser Ser Arg Cys Gln Pro Glu Ala Asn Lys Pro Thr His Asn
             100                 105                 110        
 Asn Arg Arg Asn Asp Thr Arg Ser Trp Lys Arg Asp Arg Glu Lys Arg
         115                 120                 125            
 Asp Asp Gln Asp Asp Val Ser Ser Val Arg Ser Glu Gly Gly Asn Ile
     130                 135                 140                
 Arg Gly Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly
 145                 150                 155                 160
 Arg Gly Arg Gly Asn Pro Arg Leu Asn Phe Asp Tyr Ser Tyr Gly Tyr
                 165                 170                 175    
 Gln Glu His Gly Glu Arg Thr Asp Gln Pro Phe Gln Thr Glu Leu Asn
             180                 185                 190        
 Thr Ser Met Met Tyr Tyr Tyr Asp Asp Gly Thr Gly Val Gln Val Tyr
         195                 200                 205            
 Pro Val Glu Glu Ala Leu Leu Lys Glu Tyr Ile Lys Arg Gln Ile Glu
     210                 215                 220                
 Tyr Tyr Phe Ser Val Glu Asn Leu Glu Arg Asp Phe Phe Leu Arg Gly
 225                 230                 235                 240
 Lys Met Asp Glu Gln Gly Phe Leu Pro Ile Ser Leu Ile Ala Gly Phe
                 245                 250                 255    
 Gln Arg Val Gln Ala Leu Thr Thr Asn Leu Asn Leu Ile Leu Glu Ala
             260                 265                 270        
 Leu Lys Asp Ser Thr Glu Val Glu Ile Val Asp Glu Lys Met Arg Lys
         275                 280                 285            
 Glu Ile Glu Pro Glu Lys Trp Pro Ile Pro Gly Pro Pro Pro Arg Ser
     290                 295                 300                
 Val Pro Pro Thr Asp Phe Ser Gln Leu Ile Asp Cys Pro Glu Phe Val
 305                 310                 315                 320
 Pro Gly Gln Ala Phe Cys Ser His Thr Glu Ser Ala Pro Asn Ser Pro
                 325                 330                 335    
 Arg Ile Gly Ser Pro Leu Ser Pro Lys Lys Asn Ser Glu Thr Ser Ile
             340                 345                 350        
 Leu Gln Ala Met Ser Arg Gly Leu Ser Thr Ser Leu Pro Asp Leu Asp
         355                 360                 365            
 Ser Glu Pro Trp Ile Glu Val Lys Lys Arg His Gln Pro Ala Pro Val
     370                 375                 380                
 Lys Leu Arg Glu Ser Val Ser Val Pro Glu Gly Ser Leu Asn Gln Leu
 385                 390                 395                 400
 Cys Ser Ser Glu Glu Pro Glu Gln Glu Glu Leu Asp Phe Leu Phe Asp
                 405                 410                 415    
 Glu Glu Ile Glu Gln Ile Gly Arg Lys Asn Thr Phe Thr Asp Trp Ser
             420                 425                 430        
 Asp Asn Asp Ser Asp Tyr Glu Ile Asp Asp Gln Asp Leu Asn Lys Ile
         435                 440                 445            
 Leu Ile Val Thr Gln Thr Pro Pro Tyr Val Lys Lys His Arg Gly Gly
     450                 455                 460                
 Asp Arg Thr Gly Thr His Met Ser Arg Ala Lys Ile Thr Ser Glu Leu
 465                 470                 475                 480
 Ala Lys Val Ile Asn Asp Gly Leu Tyr Tyr Tyr Glu Gln Asp Leu Trp
                 485                 490                 495    
 Met Glu Glu Asp Glu Asn Lys His Thr Ala Ile Lys Gln Glu Val Glu
             500                 505                 510        
 Asn Phe Lys Lys Leu Asn Leu Ile Ser Lys Glu Gln Phe Glu Asn Leu
         515                 520                 525            
 Thr Pro Glu Leu Pro Phe Glu Pro Asn Gln Glu Val Pro Val Ala Pro
     530                 535                 540                
 Ser Gln Ser Arg Gln Gly Gly Val Gln Gly Val Leu His Ile Pro Lys
 545                 550                 555                 560
 Lys Asp Leu Thr Asp Glu Leu Ala Gln Lys Leu Phe Asp Val Ser Glu
                 565                 570                 575    
 Ile Thr Ser Ala Ala Met Val His Ser Leu Pro Thr Ala Val Pro Glu
             580                 585                 590        
 Ser Pro Arg Ile His Pro Thr Arg Thr Pro Lys Thr Pro Arg Thr Pro
         595                 600                 605            
 Arg Leu Gln Asp Pro Asn Lys Thr Pro Arg Phe Tyr Pro Val Val Lys
     610                 615                 620                
 Glu Pro Lys Ala Ile Asp Val Lys Ser Pro Arg Lys Arg Lys Thr Arg
 625                 630                 635                 640
 His Ser Thr Asn Pro Pro Leu Glu Cys His Val Gly Trp Val Met Asp
                 645                 650                 655    
 Ser Arg Asp His Gly Pro Gly Thr Ser Ser Val Ser Thr Ser Asn Ala
             660                 665                 670        
 Ser Pro Ser Glu Gly Ala Pro Leu Ala Gly Ser Tyr Gly Cys Thr Pro
         675                 680                 685            
 His Ser Phe Pro Lys Phe Gln His Pro Ser His Glu Leu Leu Lys Glu
     690                 695                 700                
 Asn Gly Phe Thr Gln Gln Val Tyr His Lys Tyr Arg Arg Arg Cys Leu
 705                 710                 715                 720
 Ser Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser Gln Glu Met Asn Thr
                 725                 730                 735    
 Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp His Phe Asn Lys Lys
             740                 745                 750        
 Met Tyr Glu Glu Phe Arg Gln Leu Ala Trp Glu Asp Ala Lys Glu Asn
         755                 760                 765            
 Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Phe Tyr Ser Tyr Gly Leu
     770                 775                 780                
 Glu Lys Lys Phe Arg Arg Glu Ile Phe Gln Asp Phe Gln Glu Glu Thr
 785                 790                 795                 800
 Lys Lys Asp Tyr Glu Ser Gly Gln Leu Tyr Gly Leu Glu Lys Phe Trp
                 805                 810                 815    
 Ala Tyr Leu Lys Tyr Ser Gln Ser Lys Thr Gln Ser Ile Asp Pro Lys
             820                 825                 830        
 Leu Gln Glu Tyr Leu Cys Ser Phe Lys Arg Leu Glu Asp Phe Arg Val
         835                 840                 845            
 Asp Pro Pro Ile Ser Asp Glu Phe Gly Arg Lys Arg His Ser Ser Thr
     850                 855                 860                
 Ser Gly Glu Glu Ser Asn Arg His Arg Leu Pro Pro Asn Ser Ser Thr
 865                 870                 875                 880
 Lys Pro Pro Asn Ala Ala Lys Pro Thr Ser Thr Ser Glu Leu Gln Val
                 885                 890                 895    
 Pro Ile Asn Ser Pro Arg Arg Asn Ile Ser Pro Glu Ser Ser Asp Asn
             900                 905                 910        
 Ser His
        



      <210> 473
      <211> 600
      <212> PRT
      <213> Homo sapiens


      <400> 473
 Met Arg Ser Cys Leu Trp Arg Cys Arg His Leu Ser Gln Gly Val Gln
   1               5                  10                  15    
 Trp Ser Leu Leu Leu Ala Val Leu Val Phe Phe Leu Phe Ala Leu Pro
              20                  25                  30        
 Ser Phe Ile Lys Glu Pro Gln Thr Lys Pro Ser Arg His Gln Arg Thr
          35                  40                  45            
 Glu Asn Ile Lys Glu Arg Ser Leu Gln Ser Leu Ala Lys Pro Lys Ser
      50                  55                  60                
 Gln Ala Pro Thr Arg Ala Arg Arg Thr Thr Ile Tyr Ala Glu Pro Val
  65                  70                  75                  80
 Pro Glu Asn Asn Ala Leu Asn Thr Gln Thr Gln Pro Lys Ala His Thr
                  85                  90                  95    
 Thr Gly Asp Arg Gly Lys Glu Ala Asn Gln Ala Pro Pro Glu Glu Gln
             100                 105                 110        
 Asp Lys Val Pro His Thr Ala Gln Arg Ala Ala Trp Lys Ser Pro Glu
         115                 120                 125            
 Lys Glu Lys Thr Met Val Asn Thr Leu Ser Pro Arg Gly Gln Asp Ala
     130                 135                 140                
 Gly Met Ala Ser Gly Arg Thr Glu Ala Gln Ser Trp Lys Ser Gln Asp
 145                 150                 155                 160
 Thr Lys Thr Thr Gln Gly Asn Gly Gly Gln Thr Arg Lys Leu Thr Ala
                 165                 170                 175    
 Ser Arg Thr Val Ser Glu Lys His Gln Gly Lys Ala Ala Thr Thr Ala
             180                 185                 190        
 Lys Thr Leu Ile Pro Lys Ser Gln His Arg Met Leu Ala Pro Thr Gly
         195                 200                 205            
 Ala Val Ser Thr Arg Thr Arg Gln Lys Gly Val Thr Thr Ala Val Ile
     210                 215                 220                
 Pro Pro Lys Glu Lys Lys Pro Gln Ala Thr Pro Pro Pro Ala Pro Phe
 225                 230                 235                 240
 Gln Ser Pro Thr Thr Gln Arg Asn Gln Arg Leu Lys Ala Ala Asn Phe
                 245                 250                 255    
 Lys Ser Glu Pro Arg Trp Asp Phe Glu Glu Lys Tyr Ser Phe Glu Ile
             260                 265                 270        
 Gly Gly Leu Gln Thr Thr Cys Pro Asp Ser Val Lys Ile Lys Ala Ser
         275                 280                 285            
 Lys Ser Leu Trp Leu Gln Lys Leu Phe Leu Pro Asn Leu Thr Leu Phe
     290                 295                 300                
 Leu Asp Ser Arg His Phe Asn Gln Ser Glu Trp Asp Arg Leu Glu His
 305                 310                 315                 320
 Phe Ala Pro Pro Phe Gly Phe Met Glu Leu Asn Tyr Ser Leu Val Gln
                 325                 330                 335    
 Lys Val Val Thr Arg Phe Pro Pro Val Pro Gln Gln Gln Leu Leu Leu
             340                 345                 350        
 Ala Ser Leu Pro Ala Gly Ser Leu Arg Cys Ile Thr Cys Ala Val Val
         355                 360                 365            
 Gly Asn Gly Gly Ile Leu Asn Asn Ser His Met Gly Gln Glu Ile Asp
     370                 375                 380                
 Ser His Asp Tyr Val Phe Arg Leu Ser Gly Ala Leu Ile Lys Gly Tyr
 385                 390                 395                 400
 Glu Gln Asp Val Gly Thr Arg Thr Ser Phe Tyr Gly Phe Thr Ala Phe
                 405                 410                 415    
 Ser Leu Thr Gln Ser Leu Leu Ile Leu Gly Asn Arg Gly Phe Lys Asn
             420                 425                 430        
 Val Pro Leu Gly Lys Asp Val Arg Tyr Leu His Phe Leu Glu Gly Thr
         435                 440                 445            
 Arg Asp Tyr Glu Trp Leu Glu Ala Leu Leu Met Asn Gln Thr Val Met
     450                 455                 460                
 Ser Lys Asn Leu Phe Trp Phe Arg His Arg Pro Gln Glu Ala Phe Arg
 465                 470                 475                 480
 Glu Ala Leu His Met Asp Arg Tyr Leu Leu Leu His Pro Asp Phe Leu
                 485                 490                 495    
 Arg Tyr Met Lys Asn Arg Phe Leu Arg Ser Lys Thr Leu Asp Gly Ala
             500                 505                 510        
 His Trp Arg Ile Tyr Arg Pro Thr Thr Gly Ala Leu Leu Leu Leu Thr
         515                 520                 525            
 Ala Leu Gln Leu Cys Asp Gln Val Ser Ala Tyr Gly Phe Ile Thr Glu
     530                 535                 540                
 Gly His Glu Arg Phe Ser Asp His Tyr Tyr Asp Thr Ser Trp Lys Arg
 545                 550                 555                 560
 Leu Ile Phe Tyr Ile Asn His Asp Phe Lys Leu Glu Arg Glu Val Trp
                 565                 570                 575    
 Lys Arg Leu His Asp Glu Gly Ile Ile Arg Leu Tyr Gln Arg Pro Gly
             580                 585                 590        
 Pro Gly Thr Ala Lys Ala Lys Asn
         595                 600



      <210> 474
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 474
 Met Ala Arg Thr Val Tyr Cys Thr Asp Val Gly Ala Asp Leu Leu Ser
   1               5                  10                  15    
 Met Cys Gln Arg Asn Ile Ala Leu Asn Ser His Leu Ala Ala Thr Gly
              20                  25                  30        
 Gly Gly Ile Val Arg Val Lys Glu Leu Asp Trp Leu Lys Asp Asp Leu
          35                  40                  45            
 Cys Thr Asp Pro Lys Val Pro Phe Ser Trp Ser Gln Glu Glu Ile Ser
      50                  55                  60                
 Asp Leu Tyr Asp His Thr Thr Ile Leu Phe Ala Ala Glu Val Phe Tyr
  65                  70                  75                  80
 Asp Asp Asp Leu Thr Asp Ala Val Phe Lys Thr Leu Ser Arg Leu Ala
                  85                  90                  95    
 His Arg Leu Lys Asn Ala Cys Thr Ala Ile Leu Ser Val Glu Lys Arg
             100                 105                 110        
 Leu Asn Phe Thr Leu Arg His Leu Asp Val Thr Cys Glu Ala Tyr Asp
         115                 120                 125            
 His Phe Arg Ser Cys Leu His Ala Leu Glu Gln Leu Thr Asp Gly Lys
     130                 135                 140                
 Leu Arg Phe Val Val Glu Pro Val Glu Ala Ser Phe Pro Gln Leu Leu
 145                 150                 155                 160
 Val Tyr Glu Arg Leu Gln Gln Leu Glu Leu Trp Lys Ile Ile Ala Glu
                 165                 170                 175    
 Pro Val Thr
            



      <210> 475
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 475
 Met Val Gln Leu Ala Pro Ala Ala Ala Met Asp Glu Val Thr Phe Arg
   1               5                  10                  15    
 Ser Asp Thr Val Leu Ser Asp Val His Leu Tyr Thr Pro Asn His Arg
              20                  25                  30        
 His Leu Met Val Arg Leu Asn Ser Val Gly Gln Pro Val Phe Leu Ser
          35                  40                  45            
 Gln Phe Lys Leu Leu Trp Ser Gln Asp Ser Trp Thr Asp Ser Gly Ala
      50                  55                  60                
 Lys Gly Gly Ser His Arg Asp Val His Thr Lys Glu Pro Pro Ser Ala
  65                  70                  75                  80
 Glu Thr Gly Ser Thr Gly Ser Pro Pro Gly Ser Gly His Gly Asn Glu
                  85                  90                  95    
 Gly Phe Ser Leu Gln Ala Gly Thr Asp Thr Thr Gly Gln Glu Val Ala
             100                 105                 110        
 Glu Ala Gln Leu Asp Glu Asp Gly Asp Leu Asp Val Val Arg Arg Pro
         115                 120                 125            
 Arg Ala Ala Ser Asp Ser Asn Pro Ala Gly Pro Leu Arg Asp Lys Val
     130                 135                 140                
 His Pro Met Ile Leu Ala Gln Glu Glu Asp Asp Val Leu Gly Glu Glu
 145                 150                 155                 160
 Ala Gln Gly Ser Pro His Asp Ile Ile Arg Ile Glu His Thr Met Ala
                 165                 170                 175    
 Thr Pro Leu Glu Asp Val Gly Lys Gln Val Cys Gly Gly Ala Leu Leu
             180                 185                 190        
 Leu Ala Asp Tyr Ile Leu Phe Arg Gln Asp Leu Phe Arg Gly Cys Thr
         195                 200                 205            
 Ala Leu Glu Leu Gly Ala Gly Thr Gly Leu Ala Ser Ile Ile Ala Ala
     210                 215                 220                
 Thr Met Ala Arg Thr Val Tyr Cys Thr Asp Val Gly Ala Asp Leu Leu
 225                 230                 235                 240
 Ser Met Cys Gln Arg Asn Ile Ala Leu Asn Ser His Leu Ala Ala Thr
                 245                 250                 255    
 Gly Gly Gly Ile Val Arg Val Lys Glu Leu Asp Trp Leu Lys Asp Asp
             260                 265                 270        
 Leu Cys Thr Asp Pro Lys Val Pro Phe Ser Trp Ser Gln Glu Glu Ile
         275                 280                 285            
 Ser Asp Leu Tyr Asp His Thr Thr Ile Leu Phe Ala Ala Glu Val Phe
     290                 295                 300                
 Tyr Asp Asp Asp Leu Thr Asp Ala Val Phe Lys Thr Leu Ser Arg Leu
 305                 310                 315                 320
 Ala His Arg Leu Lys Asn Ala Cys Thr Ala Ile Leu Ser Val Glu Lys
                 325                 330                 335    
 Arg Leu Asn Phe Thr Leu Arg His Leu Asp Val Thr Cys Glu Ala Tyr
             340                 345                 350        
 Asp His Phe Arg Ser Cys Leu His Ala Leu Glu Gln Leu Thr Asp Gly
         355                 360                 365            
 Lys Leu Arg Phe Val Val Glu Pro Val Glu Ala Ser Phe Pro Gln Leu
     370                 375                 380                
 Leu Val Tyr Glu Arg Leu Gln Gln Leu Glu Leu Trp Lys Ile Ile Ala
 385                 390                 395                 400
 Glu Pro Val Thr
                



      <210> 476
      <211> 396
      <212> PRT
      <213> Homo sapiens


      <400> 476
 Met Ala Ala Pro Cys Val Ser Tyr Gly Gly Ala Val Ser Tyr Arg Leu
   1               5                  10                  15    
 Leu Leu Trp Gly Arg Gly Ser Leu Ala Arg Lys Gln Gly Leu Trp Lys
              20                  25                  30        
 Thr Ala Ala Pro Glu Leu Gln Thr Asn Val Arg Ser Gln Ile Leu Arg
          35                  40                  45            
 Leu Arg His Thr Ala Phe Val Ile Pro Lys Lys Asn Val Pro Thr Ser
      50                  55                  60                
 Lys Arg Glu Thr Tyr Thr Glu Asp Phe Ile Lys Lys Gln Ile Glu Glu
  65                  70                  75                  80
 Phe Asn Ile Gly Lys Arg His Leu Ala Asn Met Met Gly Glu Asp Pro
                  85                  90                  95    
 Glu Thr Phe Thr Gln Glu Asp Ile Asp Arg Ala Ile Ala Tyr Leu Phe
             100                 105                 110        
 Pro Ser Gly Leu Phe Glu Lys Arg Ala Arg Pro Val Met Lys His Pro
         115                 120                 125            
 Glu Gln Ile Phe Pro Arg Gln Arg Ala Ile Gln Trp Gly Glu Asp Gly
     130                 135                 140                
 Arg Pro Phe His Tyr Leu Phe Tyr Thr Gly Lys Gln Ser Tyr Tyr Ser
 145                 150                 155                 160
 Leu Met His Asp Val Tyr Gly Met Leu Leu Asn Leu Glu Lys His Gln
                 165                 170                 175    
 Ser His Leu Gln Ala Lys Ser Leu Leu Pro Glu Lys Thr Val Thr Arg
             180                 185                 190        
 Asp Val Ile Gly Ser Arg Trp Leu Ile Lys Glu Glu Leu Glu Glu Met
         195                 200                 205            
 Leu Val Glu Lys Leu Ser Asp Leu Asp Tyr Met Gln Phe Ile Arg Leu
     210                 215                 220                
 Leu Glu Lys Leu Leu Thr Ser Gln Cys Gly Ala Ala Glu Glu Glu Phe
 225                 230                 235                 240
 Val Gln Arg Phe Arg Arg Ser Val Thr Leu Glu Ser Lys Lys Gln Leu
                 245                 250                 255    
 Ile Glu Pro Val Gln Tyr Asp Glu Gln Gly Met Ala Phe Ser Lys Ser
             260                 265                 270        
 Glu Gly Lys Arg Lys Thr Ala Lys Ala Glu Ala Ile Val Tyr Lys His
         275                 280                 285            
 Gly Ser Gly Arg Ile Lys Val Asn Gly Ile Asp Tyr Gln Leu Tyr Phe
     290                 295                 300                
 Pro Ile Thr Gln Asp Arg Glu Gln Leu Met Phe Pro Phe His Phe Val
 305                 310                 315                 320
 Asp Arg Leu Gly Lys His Asp Val Thr Cys Thr Val Ser Gly Gly Gly
                 325                 330                 335    
 Arg Ser Ala Gln Ala Gly Ala Ile Arg Leu Ala Met Ala Lys Ala Leu
             340                 345                 350        
 Cys Ser Phe Val Thr Glu Asp Glu Val Glu Trp Met Arg Gln Ala Gly
         355                 360                 365            
 Leu Leu Thr Thr Asp Pro Arg Val Arg Glu Arg Lys Lys Pro Gly Gln
     370                 375                 380                
 Glu Gly Ala Arg Arg Lys Phe Thr Trp Lys Lys Arg
 385                 390                 395    



      <210> 477
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 477
 Met Leu Lys Lys Met Gly Glu Ala Val Ala Arg Val Ala Arg Lys Val
   1               5                  10                  15    
 Asn Glu Thr Val Glu Ser Gly Ser Asp Thr Leu Glu Leu His Leu Glu
              20                  25                  30        
 Gly Asn Phe Leu His Arg Leu Pro Ser Glu Val Ser Ala Leu Gln His
          35                  40                  45            
 Leu Lys Ala Ile Asp Leu Ser Arg Asn Gln Phe Gln Asp Phe Pro Glu
      50                  55                  60                
 Gln Leu Thr Ala Leu Pro Ala Leu Glu Thr Ile Asn Leu Glu Glu Asn
  65                  70                  75                  80
 Glu Ile Val Asp Val Pro Val Glu Lys Leu Ala Ala Met Pro Ala Leu
                  85                  90                  95    
 Arg Ser Ile Asn Leu Arg Phe Asn Pro Leu Asn Ala Glu Val Arg Val
             100                 105                 110        
 Ile Ala Pro Pro Leu Ile Lys Phe Asp Met Leu Met Ser Pro Glu Gly
         115                 120                 125            
 Ala Arg Ala Pro Leu Pro Tyr Ala Thr Leu Leu Met Pro Thr Gln Gln
     130                 135                 140                
 Gly Thr Glu Ala Thr Gly Leu Glu Pro Trp Lys Gly Gly Arg Pro Met
 145                 150                 155                 160
 Gly Gly Gln Ala Trp Gly Leu Gly Ala Gly Gly Pro Ser Ser Thr Trp
                 165                 170                 175    
 Trp Val Gly Cys Ser Trp Ser Gly
             180                



      <210> 478
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 478
 Met Asp Arg Leu Ala Arg Gly Thr Gln Ser Ile Pro Asn Asp Ser Pro
   1               5                  10                  15    
 Ala Arg Gly Glu Gly Thr His Ser Glu Glu Glu Gly Phe Ala Met Asp
              20                  25                  30        
 Glu Glu Asp Ser Asp Gly Glu Leu Asn Thr Trp Glu Leu Ser Glu Gly
          35                  40                  45            
 Thr Asn Cys Pro Pro Lys Glu Gln Pro Gly Asp Leu Phe Asn Glu Asp
      50                  55                  60                
 Trp Asp Ser Glu Leu Lys Ala Asp Gln Gly Asn Pro Tyr Asp Ala Asp
  65                  70                  75                  80
 Asp Ile Gln Glu Ser Ile Ser Gln Glu Leu Lys Pro Trp Val Cys Cys
                  85                  90                  95    
 Ala Pro Gln Gly Asp Met Ile Tyr Asp Pro Ser Trp His His Pro Pro
             100                 105                 110        
 Pro Leu Ile Pro Tyr Tyr Ser Lys Met Val Phe Glu Thr Gly Gln Phe
         115                 120                 125            
 Asp Asp Ala Glu Asp
     130            



      <210> 479
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 479
 Met Ala Ala Leu Lys Ala Leu Val Ser Gly Cys Gly Arg Leu Leu Arg
   1               5                  10                  15    
 Gly Leu Leu Ala Gly Pro Ala Ala Thr Ser Trp Ser Arg Leu Pro Ala
              20                  25                  30        
 Arg Gly Phe Arg Glu Val Val Glu Thr Gln Glu Gly Lys Thr Thr Ile
          35                  40                  45            
 Ile Glu Gly Arg Ile Thr Ala Thr Pro Lys Glu Ser Pro Asn Pro Pro
      50                  55                  60                
 Asn Pro Ser Gly Gln Cys Pro Ile Cys Arg Trp Asn Leu Lys His Lys
  65                  70                  75                  80
 Tyr Asn Tyr Asp Asp Val Leu Leu Leu Ser Gln Phe Ile Arg Pro His
                  85                  90                  95    
 Gly Gly Met Leu Pro Arg Lys Ile Thr Gly Leu Cys Gln Glu Glu His
             100                 105                 110        
 Arg Lys Ile Glu Glu Cys Val Lys Met Ala His Arg Ala Gly Leu Leu
         115                 120                 125            
 Pro Asn His Arg Pro Arg Leu Pro Glu Gly Val Val Pro Lys Ser Lys
     130                 135                 140                
 Pro Gln Leu Asn Arg Tyr Leu Thr Arg Trp Ala Pro Gly Ser Val Lys
 145                 150                 155                 160
 Pro Ile Tyr Lys Lys Gly Pro Arg Trp Asn Arg Val Arg Met Pro Val
                 165                 170                 175    
 Gly Ser Pro Leu Leu Arg Asp Asn Val Cys Tyr Ser Arg Thr Pro Trp
             180                 185                 190        
 Lys Leu Tyr His
         195    



      <210> 480
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 480
 Met Asn Lys Met Asp Gly Glu Glu Lys Thr Tyr Gly Gly Cys Glu Gly
   1               5                  10                  15    
 Pro Asp Ala Met Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe
              20                  25                  30        
 Ile Val Lys Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Ala Met
          35                  40                  45            
 Leu Ser Gly Pro Gly Gln Phe Ala Glu Asn Glu Thr Asn Glu Val Asn
      50                  55                  60                
 Phe Arg Glu Ile Pro Ser His Val Leu Ser Lys Val Cys Met Tyr Phe
  65                  70                  75                  80
 Thr Tyr Lys Val Arg Tyr Thr Asn Ser Ser Thr Glu Ile Pro Glu Phe
                  85                  90                  95    
 Pro Ile Ala Pro Glu Ile Ala Leu Glu Leu Leu Met Ala Ala Asn Phe
             100                 105                 110        
 Leu Asp Cys
         115



      <210> 481
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 481
 Met Ala Ala Ser Val Cys Ser Gly Leu Leu Gly Pro Arg Val Leu Ser
   1               5                  10                  15    
 Trp Ser Arg Glu Leu Pro Cys Ala Trp Arg Ala Leu His Thr Ser Pro
              20                  25                  30        
 Val Cys Ala Lys Asn Arg Ala Ala Arg Val Arg Val Thr Lys Gly Asp
          35                  40                  45            
 Lys Pro Val Thr Tyr Glu Glu Ala His Ala Pro His Tyr Ile Ala His
      50                  55                  60                
 Arg Lys Gly Trp Leu Ser Leu His Thr Gly Asn Leu Asp Gly Glu Asp
  65                  70                  75                  80
 His Ala Ala Glu Arg Thr Val Glu Asp Val Phe Leu Arg Lys Phe Met
                  85                  90                  95    
 Trp Gly Thr Phe Pro Gly Cys Leu Ala Asp Gln Leu Val Leu Lys Arg
             100                 105                 110        
 Arg Gly Asn Gln Leu Glu Ile Cys Ala Val Val Leu Arg Gln Leu Ser
         115                 120                 125            
 Pro His Lys Tyr Tyr Phe Leu Val Gly Tyr Ser Glu Thr Leu Leu Ser
     130                 135                 140                
 Tyr Phe Tyr Lys Cys Pro Val Arg Leu His Leu Gln Thr Val Pro Ser
 145                 150                 155                 160
 Lys Val Val Tyr Lys Tyr Leu
                 165        



      <210> 482
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 482
 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu
   1               5                  10                  15    
 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp
              20                  25                  30        
 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys
          35                  40                  45            
 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu
      50                  55                  60                
 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe
  65                  70                  75                  80
 Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser
                  85                  90                  95    
 Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile
             100                 105                 110        
 Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp
         115                 120                 125            
 Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His
     130                 135                 140                
 Leu Val Leu Arg Leu Arg Gly Gly Cys
 145                 150            



      <210> 483
      <211> 533
      <212> PRT
      <213> Homo sapiens


      <400> 483
 Met Glu His Val Thr Glu Gly Ser Trp Glu Ser Leu Pro Val Pro Leu
   1               5                  10                  15    
 His Pro Gln Val Leu Gly Ala Leu Arg Glu Leu Gly Phe Pro Tyr Met
              20                  25                  30        
 Thr Pro Val Gln Ser Ala Thr Ile Pro Leu Phe Met Arg Asn Lys Asp
          35                  40                  45            
 Val Ala Ala Glu Ala Val Thr Gly Ser Gly Lys Thr Leu Ala Phe Val
      50                  55                  60                
 Ile Pro Ile Leu Glu Ile Leu Leu Arg Arg Glu Glu Lys Leu Lys Lys
  65                  70                  75                  80
 Ser Gln Val Gly Ala Ile Ile Ile Thr Pro Thr Arg Glu Leu Ala Ile
                  85                  90                  95    
 Gln Ile Asp Glu Val Leu Ser His Phe Thr Lys His Phe Pro Glu Phe
             100                 105                 110        
 Ser Gln Ile Leu Trp Ile Gly Gly Arg Asn Pro Gly Glu Asp Val Glu
         115                 120                 125            
 Arg Phe Lys Gln Gln Gly Gly Asn Ile Ile Val Ala Thr Pro Gly Arg
     130                 135                 140                
 Leu Glu Asp Met Phe Arg Arg Lys Ala Glu Gly Leu Asp Leu Ala Ser
 145                 150                 155                 160
 Cys Val Arg Ser Leu Asp Val Leu Val Leu Asp Glu Ala Asp Arg Leu
                 165                 170                 175    
 Leu Asp Met Gly Phe Glu Ala Ser Ile Asn Thr Ile Leu Glu Phe Leu
             180                 185                 190        
 Pro Lys Gln Arg Arg Thr Gly Leu Phe Ser Ala Thr Gln Thr Gln Glu
         195                 200                 205            
 Val Glu Asn Leu Val Arg Ala Gly Leu Arg Asn Pro Val Arg Val Ser
     210                 215                 220                
 Val Lys Glu Lys Gly Val Ala Ala Ser Ser Ala Gln Lys Thr Pro Ser
 225                 230                 235                 240
 Arg Leu Glu Asn Tyr Tyr Met Val Cys Lys Ala Asp Glu Lys Phe Asn
                 245                 250                 255    
 Gln Leu Val His Phe Leu Arg Asn His Lys Gln Glu Lys His Leu Val
             260                 265                 270        
 Phe Phe Ser Thr Cys Ala Cys Val Glu Tyr Tyr Gly Lys Ala Leu Glu
         275                 280                 285            
 Val Leu Val Lys Gly Val Lys Ile Met Cys Ile His Gly Lys Met Lys
     290                 295                 300                
 Tyr Lys Arg Asn Lys Ile Phe Met Glu Phe Arg Lys Leu Gln Ser Gly
 305                 310                 315                 320
 Ile Leu Val Cys Thr Asp Val Met Ala Arg Gly Ile Asp Ile Pro Glu
                 325                 330                 335    
 Val Asn Trp Val Leu Gln Tyr Asp Pro Pro Ser Asn Ala Ser Ala Phe
             340                 345                 350        
 Val His Arg Cys Gly Arg Thr Ala Arg Ile Gly His Gly Gly Ser Ala
         355                 360                 365            
 Leu Val Phe Leu Leu Pro Met Glu Glu Ser Tyr Ile Asn Phe Leu Ala
     370                 375                 380                
 Ile Asn Gln Lys Cys Pro Leu Gln Glu Met Lys Pro Gln Arg Asn Thr
 385                 390                 395                 400
 Ala Asp Leu Leu Pro Lys Leu Lys Ser Met Ala Leu Ala Asp Arg Ala
                 405                 410                 415    
 Val Phe Glu Lys Gly Met Lys Ala Phe Val Ser Tyr Val Gln Ala Tyr
             420                 425                 430        
 Ala Lys His Glu Cys Asn Leu Ile Phe Arg Leu Lys Asp Leu Asp Phe
         435                 440                 445            
 Ala Ser Leu Ala Arg Gly Phe Ala Leu Leu Arg Met Pro Lys Met Pro
     450                 455                 460                
 Glu Leu Arg Gly Lys Gln Phe Pro Asp Phe Val Pro Val Asp Val Asn
 465                 470                 475                 480
 Thr Asp Thr Ile Pro Phe Lys Asp Lys Ile Arg Glu Lys Gln Arg Gln
                 485                 490                 495    
 Lys Leu Leu Glu Gln Gln Arg Arg Glu Lys Thr Glu Asn Glu Gly Arg
             500                 505                 510        
 Arg Lys Phe Ile Lys Asn Lys Ala Trp Ser Lys Gln Lys Ala Lys Lys
         515                 520                 525            
 Lys Leu Ser Leu Phe
     530            



      <210> 484
      <211> 532
      <212> PRT
      <213> Homo sapiens


      <400> 484
 Met Ile Lys Gln Ile Leu Pro Glu His Ser Val Leu Gln Asn Ile Asn
   1               5                  10                  15    
 Phe Val Glu Ala Phe Gln Asp Glu Leu Leu Val Thr Glu Val Tyr Asp
              20                  25                  30        
 Leu Pro Gln Arg Pro Asn Asp Val Gln Leu Phe Tyr Gly Ser Met Cys
          35                  40                  45            
 Lys Ile Ile Leu Ser Val Ile Gly Glu Phe Arg Asp Cys Ile Ser Ser
      50                  55                  60                
 Arg Glu Phe Leu Gln Pro Ser Ser Lys Ala Ser Leu Glu Ser Thr Ser
  65                  70                  75                  80
 Asp Leu Gly Ala Ser Gly Lys His Gly Gly Asn Val Ser Leu Asp Val
                  85                  90                  95    
 Leu Pro Val Lys Gly Pro Gln Gly Ser Pro Leu Leu Ser Arg Ala Ala
             100                 105                 110        
 Arg Pro Pro Pro Asp Gln Leu Ala Ser Glu Glu Pro Trp Thr Val Leu
         115                 120                 125            
 Pro Glu His Leu Ile Leu Val Ala Pro Ser Pro Cys Asp Met Ala Lys
     130                 135                 140                
 Thr Gly Arg Phe Gln Ile Val Asn Asn Ser Val Arg Leu Leu Arg Phe
 145                 150                 155                 160
 Glu Leu Cys Trp Pro Ala His Cys Leu Thr Val Thr Pro Gln His Gly
                 165                 170                 175    
 Cys Val Ala Pro Glu Ser Lys Leu Gln Ile Leu Val Ser Pro Asn Ser
             180                 185                 190        
 Ser Leu Ser Thr Lys Gln Ser Met Phe Pro Trp Ser Gly Leu Ile Tyr
         195                 200                 205            
 Ile His Cys Asp Asp Gly Gln Lys Lys Ile Val Lys Val Gln Ile Arg
     210                 215                 220                
 Glu Asp Leu Thr Gln Val Glu Leu Leu Thr Arg Leu Thr Ser Lys Pro
 225                 230                 235                 240
 Phe Gly Ile Leu Ser Pro Val Ser Glu Pro Ser Val Ser His Leu Val
                 245                 250                 255    
 Lys Pro Met Thr Lys Pro Pro Ser Thr Lys Val Glu Ile Arg Asn Lys
             260                 265                 270        
 Ser Ile Thr Phe Pro Thr Thr Glu Pro Gly Glu Thr Ser Glu Ser Cys
         275                 280                 285            
 Leu Glu Leu Glu Asn His Gly Thr Thr Asp Val Lys Trp His Leu Ser
     290                 295                 300                
 Ser Leu Ala Pro Pro Tyr Val Lys Gly Val Asp Glu Ser Gly Asp Val
 305                 310                 315                 320
 Phe Arg Ala Thr Tyr Ala Ala Phe Arg Cys Ser Pro Ile Ser Gly Leu
                 325                 330                 335    
 Leu Glu Ser His Gly Ile Gln Lys Val Ser Ile Thr Phe Leu Pro Arg
             340                 345                 350        
 Gly Arg Gly Asp Tyr Ala Gln Phe Trp Asp Val Glu Cys His Pro Leu
         355                 360                 365            
 Lys Glu Pro His Met Lys His Thr Leu Arg Phe Gln Leu Ser Gly Gln
     370                 375                 380                
 Ser Ile Glu Ala Glu Asn Glu Pro Glu Asn Ala Cys Leu Ser Thr Asp
 385                 390                 395                 400
 Ser Leu Ile Lys Ile Asp His Leu Val Lys Pro Arg Arg Gln Ala Val
                 405                 410                 415    
 Ser Glu Ala Ser Ala Arg Ile Pro Glu Gln Leu Asp Val Thr Ala Arg
             420                 425                 430        
 Gly Val Tyr Ala Pro Glu Asp Val Tyr Arg Phe Leu Pro Thr Ser Val
         435                 440                 445            
 Gly Glu Ser Arg Thr Leu Lys Val Asn Leu Arg Asn Asn Ser Phe Ile
     450                 455                 460                
 Thr His Ser Leu Lys Phe Leu Ser Pro Arg Glu Pro Phe Tyr Val Lys
 465                 470                 475                 480
 His Ser Lys Tyr Ser Leu Arg Ala Gln His Tyr Ile Asn Met Pro Val
                 485                 490                 495    
 Gln Phe Lys Pro Lys Ser Ala Gly Lys Phe Glu Ala Leu Leu Val Ile
             500                 505                 510        
 Gln Thr Asp Glu Gly Lys Ser Ile Ala Ile Arg Leu Ile Gly Glu Ala
         515                 520                 525            
 Leu Gly Lys Asn
     530        



      <210> 485
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 485
 Met Ala Ser Ser Glu Val Ala Arg His Leu Leu Phe Gln Ser His Met
   1               5                  10                  15    
 Ala Thr Lys Thr Thr Cys Met Ser Ser Gln Gly Ser Asp Asp Glu Gln
              20                  25                  30        
 Ile Lys Arg Glu Asn Ile Arg Ser Leu Thr Met Ser Gly His Val Gly
          35                  40                  45            
 Phe Glu Ser Leu Pro Asp Gln Leu Val Asn Arg Ser Ile Gln Gln Gly
      50                  55                  60                
 Phe Cys Phe Asn Ile Leu Cys Val Gly Glu Thr Gly Ile Gly Lys Ser
  65                  70                  75                  80
 Thr Leu Ile Asp Thr Leu Phe Asn Thr Asn Phe Glu Asp Tyr Glu Ser
                  85                  90                  95    
 Ser His Phe Cys Pro Asn Val Lys Leu Lys Ala Gln Thr Tyr Glu Leu
             100                 105                 110        
 Gln Glu Ser Asn Val Gln Leu Lys Leu Thr Ile Val Asn Thr Val Gly
         115                 120                 125            
 Phe Gly Asp Gln Ile Asn Lys Glu Glu Ser Tyr Gln Pro Ile Val Asp
     130                 135                 140                
 Tyr Ile Asp Ala Gln Phe Glu Ala Tyr Leu Gln Glu Glu Leu Lys Ile
 145                 150                 155                 160
 Lys Arg Ser Leu Phe Thr Tyr His Asp Ser Arg Ile His Val Cys Leu
                 165                 170                 175    
 Tyr Phe Ile Ser Pro Thr Gly His Ser Leu Lys Thr Leu Asp Leu Leu
             180                 185                 190        
 Thr Met Lys Asn Leu Asp Ser Lys Val Asn Ile Ile Pro Val Ile Ala
         195                 200                 205            
 Lys Ala Asp Thr Val Ser Lys Thr Glu Leu Gln Lys Phe Lys Ile Lys
     210                 215                 220                
 Leu Met Ser Glu Leu Val Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro
 225                 230                 235                 240
 Thr Asp Asp Asp Thr Ile Ala Lys Val Asn Ala Ala Met Asn Gly Gln
                 245                 250                 255    
 Leu Pro Phe Ala Val Val Gly Ser Met Asp Glu Val Lys Val Gly Asn
             260                 265                 270        
 Lys Met Val Lys Ala Arg Gln Tyr Pro Trp Gly Val Val Gln Val Glu
         275                 280                 285            
 Asn Glu Asn His Cys Asp Phe Val Lys Leu Arg Glu Met Leu Ile Cys
     290                 295                 300                
 Thr Asn Met Glu Asp Leu Arg Glu Gln Thr His Thr Arg His Tyr Glu
 305                 310                 315                 320
 Leu Tyr Arg Arg Cys Lys Leu Glu Glu Met Gly Phe Thr Asp Val Gly
                 325                 330                 335    
 Pro Glu Asn Lys Pro Val Ser Val Gln Glu Thr Tyr Glu Ala Lys Arg
             340                 345                 350        
 His Glu Phe His Gly Glu Arg Gln Arg Lys Glu Glu Glu Met Lys Gln
         355                 360                 365            
 Met Phe Val Gln Arg Val Lys Glu Lys Glu Ala Ile Leu Lys Glu Ala
     370                 375                 380                
 Glu Arg Glu Leu Gln Ala Lys Phe Glu His Leu Lys Arg Leu His Gln
 385                 390                 395                 400
 Glu Glu Arg Met Lys Leu Glu Glu Lys Arg Arg Leu Leu Glu Glu Glu
                 405                 410                 415    
 Ile Ile Ala Phe Ser Lys Lys Lys Ala Thr Ser Glu Ile Phe His Ser
             420                 425                 430        
 Gln Ser Phe Leu Ala Thr Gly Ser Asn Leu Arg Lys Asp Lys Asp Arg
         435                 440                 445            
 Lys Asn Ser Asn Phe Leu
     450                



      <210> 486
      <211> 708
      <212> PRT
      <213> Homo sapiens


      <400> 486
 Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu
   1               5                  10                  15    
 Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro
              20                  25                  30        
 Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp
          35                  40                  45            
 Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro
      50                  55                  60                
 Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr
  65                  70                  75                  80
 Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu
                  85                  90                  95    
 Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg
             100                 105                 110        
 Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg
         115                 120                 125            
 Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn
     130                 135                 140                
 Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr
 145                 150                 155                 160
 Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg
                 165                 170                 175    
 Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser
             180                 185                 190        
 Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser
         195                 200                 205            
 Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser
     210                 215                 220                
 Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly
 225                 230                 235                 240
 Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys
                 245                 250                 255    
 Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly
             260                 265                 270        
 Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly
         275                 280                 285            
 Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn
     290                 295                 300                
 Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile
 305                 310                 315                 320
 Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser
                 325                 330                 335    
 Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr
             340                 345                 350        
 Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly
         355                 360                 365            
 Asp Phe Ala Cys Tyr Ile Leu Thr Asp Leu Val Thr Phe Thr Leu Ala
     370                 375                 380                
 Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp
 385                 390                 395                 400
 Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro
                 405                 410                 415    
 Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu
             420                 425                 430        
 Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val
         435                 440                 445            
 Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys
     450                 455                 460                
 Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg
 465                 470                 475                 480
 Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe
                 485                 490                 495    
 Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser
             500                 505                 510        
 Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val
         515                 520                 525            
 Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr
     530                 535                 540                
 Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly
 545                 550                 555                 560
 Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro
                 565                 570                 575    
 Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met
             580                 585                 590        
 Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr
         595                 600                 605            
 Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg
     610                 615                 620                
 Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu
 625                 630                 635                 640
 Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr
                 645                 650                 655    
 Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn
             660                 665                 670        
 His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg
         675                 680                 685            
 Gln Ile Arg Pro Cys Thr Ser Leu Ser Asp Gly Glu Glu Asp Glu Asp
     690                 695                 700                
 Asp Glu Asp Glu
 705            



      <210> 487
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 487
 Met Tyr Met Tyr Thr Ser Cys Thr Lys His Val Met Leu Leu Ser Ser
   1               5                  10                  15    
 Gly Glu Ala Thr Ser Thr Ile Lys Cys Gly Ser Lys Thr Ala Ser Asp
              20                  25                  30        
 Phe Leu Thr Ser Gln Ala Gly Thr Phe Arg Ser Phe Pro Ser Arg Cys
          35                  40                  45            
 Thr Glu Gly Thr Thr Glu Pro Thr Val Cys Arg Val Cys Val Pro Arg
      50                  55                  60                
 Ala Leu Pro Trp Pro Pro Pro Ala Leu Ala Ser Gly Leu Gln Ser Gln
  65                  70                  75                  80
 Val Pro Ile Leu Gly Ala Leu Ser Cys Ser Pro Asp Pro Gly Val Cys
                  85                  90                  95    
 Pro Gly Val Lys Ser Arg Arg
             100            



      <210> 488
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 488
 Met Ala Arg Arg Pro Arg Asn Ser Arg Ala Trp His Phe Val Leu Ser
   1               5                  10                  15    
 Ala Ala Arg Arg Asp Ala Asp Ala Arg Ala Val Ala Leu Ala Gly Ser
              20                  25                  30        
 Thr Asn Trp Gly Tyr Asp Ser Asp Gly Gln His Ser Asp Ser Asp Ser
          35                  40                  45            
 Asp Pro Glu Tyr Ser Thr Leu Pro Pro Ser Ile Pro Ser Ala Val Pro
      50                  55                  60                
 Val Thr Gly Glu Ser Phe Cys Asp Cys Ala Gly Gln Ser Glu Ala Ser
  65                  70                  75                  80
 Phe Cys Ser Ser Leu His Ser Ala His Arg Gly Arg Asp Cys Arg Cys
                  85                  90                  95    
 Gly Glu Glu Asp Glu Tyr Phe Asp Trp Val Trp Asp Asp Leu Asn Lys
             100                 105                 110        
 Ser Ser Ala Thr Leu Leu Ser Cys Asp Asn Arg Lys Val Ser Phe His
         115                 120                 125            
 Met Glu Tyr Ser Cys Gly Thr Ala Ala Ile Arg Gly Thr Lys Glu Leu
     130                 135                 140                
 Gly Glu Gly Gln His Phe Trp Glu Ile Lys Met Thr Ser Pro Val Tyr
 145                 150                 155                 160
 Gly Thr Asp Met Met Val Gly Ile Gly Thr Ser Asp Val Asp Leu Asp
                 165                 170                 175    
 Lys Tyr Arg His Thr Phe Cys Ser Leu Leu Gly Arg Asp Glu Asp Ser
             180                 185                 190        
 Trp Gly Leu Ser Tyr Thr Gly Leu Leu His His Lys Gly Asp Lys Thr
         195                 200                 205            
 Ser Phe Ser Ser Arg Phe Gly Gln Gly Ser Ile Ile Gly Val His Leu
     210                 215                 220                
 Asp Thr Trp His Gly Thr Leu Thr Phe Phe Lys Asn Arg Lys Cys Ile
 225                 230                 235                 240
 Gly Trp Ala Pro Pro Phe Gln Val Trp Gln Pro Pro Ser Cys Arg Thr
                 245                 250                 255    
 Arg Asp Ser Thr Arg Trp Cys Ala Pro Arg Arg Pro Gly Ala Ala
             260                 265                 270    



      <210> 489
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 489
 Met Gly Phe Phe Ser Arg Arg Thr Phe Cys Gly Arg Ser Gly Arg Ser
   1               5                  10                  15    
 Cys Arg Gly Gln Leu Val Gln Val Ser Arg Pro Glu Val Ser Ala Gly
              20                  25                  30        
 Ser Leu Leu Leu Pro Ala Pro Gln Ala Glu Asp His Ser Ser Arg Ile
          35                  40                  45            
 Leu Tyr Pro Arg Pro Lys Ser Leu Leu Pro Lys Met Met Asn Ala Asp
      50                  55                  60                
 Met Asp Ala Val Asp Ala Glu Asn Gln Val Glu Leu Glu Glu Lys Thr
  65                  70                  75                  80
 Arg Leu Ile Asn Gln Val Leu Glu Leu Gln His Thr Leu Glu Asp Leu
                  85                  90                  95    
 Ser Ala Arg Val Asp Ala Val Lys Glu Glu Asn Leu Lys Leu Lys Ser
             100                 105                 110        
 Glu Asn Gln Val Leu Gly Gln Tyr Ile Glu Asn Leu Met Ser Ala Ser
         115                 120                 125            
 Ser Val Phe Gln Thr Thr Asp Thr Lys Ser Lys Arg Lys
     130                 135                 140    



      <210> 490
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 490
 Met Gln Asp Glu Asp Gly Tyr Ile Thr Leu Asn Ile Lys Thr Arg Lys
   1               5                  10                  15    
 Pro Ala Leu Val Ser Val Gly Ser Ala Ser Ser Ser Trp Trp Arg Val
              20                  25                  30        
 Met Ala Leu Ile Leu Leu Ile Leu Cys Val Gly Met Val Val Gly Leu
          35                  40                  45            
 Val Ala Leu Gly Ile Trp Ser Val Met Gln Arg Asn Tyr Leu Gln Asp
      50                  55                  60                
 Glu Asn Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe
  65                  70                  75                  80
 Cys Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly
                  85                  90                  95    
 His Lys Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser
             100                 105                 110        
 Cys Tyr Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln
         115                 120                 125            
 Tyr Cys Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn
     130                 135                 140                
 Ile Val Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly
 145                 150                 155                 160
 Leu Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser
                 165                 170                 175    
 Val Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn
             180                 185                 190        
 Met Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys
         195                 200                 205            
 Glu Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys
     210                 215                 220                
 Val Asp Gln Leu Pro
 225                



      <210> 491
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 491
 Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser
   1               5                  10                  15    
 Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg Ile His
              20                  25                  30        
 Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gln Asp
          35                  40                  45            
 Phe Lys Leu Asp Phe Gly Asn Ser Gln Gly Lys Thr Ser Gln Thr Trp
      50                  55                  60                
 His Gly Gly Ile Ala Thr Ile Phe Gln Ser Pro Gly Asp Glu Val Trp
  65                  70                  75                  80
 Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu
                  85                  90                  95    
 Gln Glu Gly Val Lys Ser Gly Met Tyr Val Val Ile Glu Val Lys Val
             100                 105                 110        
 Ala Thr Gln Glu Gly Lys Glu Ile Thr Cys Arg Ser Tyr Leu Met Thr
         115                 120                 125            
 Asn Tyr Glu Ser Ala Pro Pro Ser Pro Gln Tyr Lys Lys Ile Ile Cys
     130                 135                 140                
 Met Gly Ala Lys Glu Asn Gly Leu Pro Leu Glu Tyr Gln Glu Lys Leu
 145                 150                 155                 160
 Lys Ala Ile Glu Pro Asn Asp Tyr Thr Gly Lys Val Ser Glu Glu Ile
                 165                 170                 175    
 Glu Asp Ile Ile Lys Lys Gly Glu Thr Gln Thr Leu
             180                 185            



      <210> 492
      <211> 483
      <212> PRT
      <213> Homo sapiens


      <400> 492
 Met Ala Ser Leu Leu Trp Gly Gly Asp Ala Gly Ala Ala Glu Ser Glu
   1               5                  10                  15    
 Arg Leu Asn Ser His Phe Ser Asn Leu Ser Gln Pro Arg Lys Asn Leu
              20                  25                  30        
 Trp Gly Ile Lys Ser Thr Ala Val Arg Asn Ile Asp Gly Ser Ile Asn
          35                  40                  45            
 Asn Ile Asn Glu Asp Asp Glu Glu Asp Val Val Asp Leu Ala Ala Asn
      50                  55                  60                
 Ser Leu Leu Asn Lys Leu Ile His Gln Ser Leu Val Glu Ser Ser His
  65                  70                  75                  80
 Arg Val Glu Val Leu Gln Lys Asp Pro Ser Ser Pro Leu Tyr Ser Val
                  85                  90                  95    
 Lys Thr Phe Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile
             100                 105                 110        
 Tyr Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu
         115                 120                 125            
 Pro Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln
     130                 135                 140                
 Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg
 145                 150                 155                 160
 Val Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr
                 165                 170                 175    
 Tyr Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys
             180                 185                 190        
 Phe Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile
         195                 200                 205            
 Pro Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly
     210                 215                 220                
 Thr Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys
 225                 230                 235                 240
 Ile Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln
                 245                 250                 255    
 Gly Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu
             260                 265                 270        
 Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His
         275                 280                 285            
 Phe Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys
     290                 295                 300                
 Glu Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu
 305                 310                 315                 320
 His Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile
                 325                 330                 335    
 Thr Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys
             340                 345                 350        
 Trp Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu
         355                 360                 365            
 Ser Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe
     370                 375                 380                
 Arg Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg
 385                 390                 395                 400
 Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro
                 405                 410                 415    
 Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile
             420                 425                 430        
 Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile
         435                 440                 445            
 Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn
     450                 455                 460                
 Ser Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys
 465                 470                 475                 480
 Ile Asp Tyr
            



      <210> 493
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 493
 Met Asn Gly Pro Thr Leu Arg Pro Thr Ser Ser Ile Pro Ala Asn Asn
   1               5                  10                  15    
 Pro Leu Val Thr Gln Leu Leu Gln Gly Lys Asp Val Pro Met Glu Gln
              20                  25                  30        
 Ile Leu Pro Lys Pro Leu Thr Lys Val Glu Met Lys Thr Val Pro Leu
          35                  40                  45            
 Thr Ala Lys Glu Glu Arg Gly Met Gly Ala Leu Ile Ala Thr Asn Thr
      50                  55                  60                
 Thr Glu Asn Ser Thr Arg Glu Glu Val Asn Glu Arg Gln Ser His Pro
  65                  70                  75                  80
 Ala Thr Gln Gln Gln Leu Gly Lys Thr Leu Gln Ser Lys Gln Leu Pro
                  85                  90                  95    
 Gln Val Pro Arg Pro Leu Gln Leu Phe Ser Ala Lys Glu Leu Arg Asp
             100                 105                 110        
 Ser Ser Ile Asp Thr His Gln Tyr His Glu Gly Leu Ser Lys Ala Thr
         115                 120                 125            
 Gln Asp Gln Ile Leu Gln Thr Leu Ile Gln Arg Val Arg Arg Gln Asn
     130                 135                 140                
 Leu Leu Ser Val Val Pro Pro Ser Gln Phe Asn Phe Ala His Ser Gly
 145                 150                 155                 160
 Phe Gln Leu Glu Asp Ile Ser Thr Ser Gln Arg Phe Met Leu Gly Phe
                 165                 170                 175    
 Ala Gly Arg Arg Thr Ser Lys Pro Ala Met Ala Gly His Tyr Leu Leu
             180                 185                 190        
 Asn Ile Ser Thr Tyr Gly Arg Gly Ser Glu Ser Phe Arg Arg Thr His
         195                 200                 205            
 Ser Val Asn Pro Glu Asp Arg Phe Cys Leu Ser Ser Pro Thr Glu Ala
     210                 215                 220                
 Leu Lys Met Gly Tyr Thr Asp Cys Lys Asn Ala Thr Gly Glu Ser Ser
 225                 230                 235                 240
 Ser Ser Lys Glu Asp Asp Thr Asp Glu Glu Ser Thr Gly Asp Glu Gln
                 245                 250                 255    
 Glu Ser Val Thr Val Lys Glu Glu Pro Gln Val Ser Gln Ser Ala Gly
             260                 265                 270        
 Lys Gly Asp Thr Ser Ser Gly Pro His Ser Arg Glu Thr Leu Ser Thr
         275                 280                 285            
 Ser Asp Cys Leu Ala Ser Lys Asn Val Lys Ala Glu Ile Pro Leu Asn
     290                 295                 300                
 Glu Gln Thr Thr Leu Ser Lys Glu Asn Tyr Leu Phe Thr Arg Gly Gln
 305                 310                 315                 320
 Thr Phe Asp Glu Lys Thr Leu Ala Arg Asp Leu Ile Gln Ala Ala Gln
                 325                 330                 335    
 Lys Gln Met Ala His Ala Val Arg Gly Lys Ala Ile Arg Ser Ser Pro
             340                 345                 350        
 Glu Leu Phe Ser Ser Thr Val Leu Pro Leu Pro Ala Asp Ser Pro Thr
         355                 360                 365            
 His Gln Pro Leu Leu Leu Pro Pro Leu Gln Thr Pro Lys Leu Tyr Gly
     370                 375                 380                
 Ser Pro Thr Gln Ile Gly Pro Ser Tyr Arg Gly Met Ile Asn Val Ser
 385                 390                 395                 400
 Thr Ser Ser Asp Met Asp His Asn Ser Ala Val Pro Gly Ser Gln Val
                 405                 410                 415    
 Ser Ser Asn Val Gly Asp Val Met Ser Phe Ser Val Thr Val Thr Thr
             420                 425                 430        
 Ile Pro Ala Ser Gln Ala Met Asn Pro Ser Ser His Gly Gln Thr Ile
         435                 440                 445            
 Pro Val Gln Ala Phe Ser Glu Glu Asn Ser Ile Glu Gly Thr Pro Ser
     450                 455                 460                
 Lys Cys Tyr Cys Arg Leu Lys Ala Met Ile Met Cys Lys Gly Cys Gly
 465                 470                 475                 480
 Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys Leu Cys Val Ser
                 485                 490                 495    
 Cys Leu Val Val Arg
             500    



      <210> 494
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 494
 Met Asp Thr Pro Ser Pro Asp Pro Leu Pro Ser Pro Leu Pro Gly Glu
   1               5                  10                  15    
 Glu Glu Lys Pro Leu Ala Leu Ser Pro Pro Val Pro Arg Gly Arg Arg
              20                  25                  30        
 Gly Arg Arg Pro Gly Gly Ala Thr Ser Ser Asn Arg Thr Leu Lys Ala
          35                  40                  45            
 Ser Leu Pro Arg Lys Arg Gly Arg Pro Pro Lys Ser Gly Gln Glu Pro
      50                  55                  60                
 Pro Leu Val Gln Val Gln Gly Val Thr Ala Pro Val Gly Ser Ser Gly
  65                  70                  75                  80
 Gly Ser Asp Leu Leu Leu Ile Asp Asp Gln Gly Val Pro Tyr Thr Val
                  85                  90                  95    
 Ser Glu Gly Ser Ala Ala Gly Pro Glu Gly Ser Gly Pro Arg Lys Ala
             100                 105                 110        
 Pro His Phe Cys Pro Val Cys Leu Arg Ala Phe Pro Tyr Leu Ser Asp
         115                 120                 125            
 Leu Glu Arg His Ser Ile Ser His Ser Glu Leu Lys Pro His Gln Cys
     130                 135                 140                
 Lys Val Cys Gly Lys Thr Phe Lys Arg Ser Ser His Leu Arg Arg His
 145                 150                 155                 160
 Cys Asn Ile His Ala Gly Leu Arg Pro Phe Arg Cys Pro Leu Cys Pro
                 165                 170                 175    
 Arg Arg Phe Arg Glu Ala Gly Glu Leu Ala His His His Arg Val His
             180                 185                 190        
 Ser Gly Glu Arg Pro Tyr Gln Cys Pro Ile Cys Arg Leu Arg Phe Thr
         195                 200                 205            
 Glu Ala Asn Thr Leu Arg Arg His Ala Lys Arg Lys His Pro Glu Ala
     210                 215                 220                
 Met Gly Val Pro Leu Cys Ala Pro Asp Pro Gly Ser Glu Pro Pro Trp
 225                 230                 235                 240
 Asp Glu Glu Gly Ile Pro Ala Thr Ala Gly Ala Glu Glu Glu Glu Glu
                 245                 250                 255    
 Thr Glu Gly Lys Gly Glu Pro Ala
             260                



      <210> 495
      <211> 498
      <212> PRT
      <213> Homo sapiens


      <400> 495
 Met Glu Asp Thr Gln Arg Leu Asp Glu Leu Gln Lys Gln Leu Gln Glu
   1               5                  10                  15    
 Asp Ile Arg Gln Gly Arg Gly Ile Lys Ser Pro Ile Arg Ile Gly Glu
              20                  25                  30        
 Glu Asp Ser Thr Asp Asp Glu Asp Gly Leu Leu Glu Glu His Lys Glu
          35                  40                  45            
 Phe Leu Lys Lys Phe Ser Val Thr Ile Asp Ala Ile Pro Asp His His
      50                  55                  60                
 Pro Gly Glu Glu Ile Phe Asn Phe Leu Asn Ser Gly Lys Ile Phe Asn
  65                  70                  75                  80
 Gln Tyr Thr Leu Asp Leu Arg Asp Ser Gly Phe Ile Gly Gln Ser Ala
                  85                  90                  95    
 Val Glu Lys Leu Ile Leu Lys Ser Gly Lys Thr Asp Gln Ile Phe Leu
             100                 105                 110        
 Thr Thr Gln Gly Phe Leu Thr Ser Ala Tyr His Tyr Val Gln Cys Pro
         115                 120                 125            
 Val Pro Val Leu Lys Trp Leu Phe Arg Met Met Ser Val His Thr Asp
     130                 135                 140                
 Cys Ile Val Ser Val Gln Ile Leu Ser Thr Leu Met Glu Ile Thr Ile
 145                 150                 155                 160
 Arg Asn Asp Thr Phe Ser Asp Ser Pro Val Trp Pro Trp Ile Pro Ser
                 165                 170                 175    
 Leu Ser Asp Val Ala Ala Val Phe Phe Asn Met Gly Ile Asp Phe Arg
             180                 185                 190        
 Ser Leu Phe Pro Leu Glu Asn Leu Gln Pro Asp Phe Asn Glu Asp Tyr
         195                 200                 205            
 Leu Val Ser Glu Thr Gln Thr Thr Ser Arg Gly Lys Glu Ser Glu Asp
     210                 215                 220                
 Ser Ser Tyr Lys Pro Ile Phe Ser Thr Leu Pro Glu Thr Asn Ile Leu
 225                 230                 235                 240
 Asn Val Val Lys Phe Leu Gly Leu Cys Thr Ser Ile His Pro Glu Gly
                 245                 250                 255    
 Tyr Gln Asp Arg Glu Ile Met Leu Leu Ile Leu Met Leu Phe Lys Met
             260                 265                 270        
 Ser Leu Glu Lys Gln Leu Lys Gln Ile Pro Leu Val Asp Phe Gln Ser
         275                 280                 285            
 Leu Leu Ile Asn Leu Met Lys Asn Ile Arg Asp Trp Asn Thr Lys Val
     290                 295                 300                
 Pro Glu Leu Cys Leu Gly Ile Asn Glu Leu Ser Ser His Pro His Asn
 305                 310                 315                 320
 Leu Leu Trp Leu Val Gln Leu Val Pro Asn Trp Thr Ser Arg Gly Arg
                 325                 330                 335    
 Gln Leu Arg Gln Cys Leu Ser Leu Val Ile Ile Ser Lys Leu Leu Asp
             340                 345                 350        
 Glu Lys His Glu Asp Val Pro Asn Ala Ser Asn Leu Gln Val Ser Val
         355                 360                 365            
 Leu His Arg Tyr Leu Val Gln Met Lys Pro Ser Asp Leu Leu Lys Lys
     370                 375                 380                
 Met Val Leu Lys Lys Lys Ala Glu Gln Pro Asp Gly Ile Ile Asp Asp
 385                 390                 395                 400
 Ser Leu His Leu Glu Leu Glu Lys Gln Ala Tyr Tyr Leu Thr Tyr Ile
                 405                 410                 415    
 Leu Leu His Leu Val Gly Glu Val Ser Cys Ser His Ser Phe Ser Ser
             420                 425                 430        
 Gly Gln Arg Lys His Phe Val Leu Leu Cys Gly Ala Leu Glu Lys His
         435                 440                 445            
 Val Lys Cys Asp Ile Arg Glu Asp Ala Arg Leu Phe Tyr Arg Thr Lys
     450                 455                 460                
 Val Lys Asp Leu Val Ala Arg Ile His Gly Lys Trp Gln Glu Ile Ile
 465                 470                 475                 480
 Gln Asn Cys Arg Pro Thr Gln Gly Gln Leu His Asp Phe Trp Val Pro
                 485                 490                 495    
 Asp Ser
        



      <210> 496
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 496
 Met Glu Asp Thr Gln Arg Leu Asp Glu Leu Gln Lys Gln Leu Gln Glu
   1               5                  10                  15    
 Asp Ile Arg Gln Gly Arg Gly Ile Lys Ser Pro Ile Arg Ile Gly Glu
              20                  25                  30        
 Glu Asp Ser Thr Asp Asp Glu Asp Gly Leu Leu Glu Glu His Lys Glu
          35                  40                  45            
 Phe Leu Lys Lys Phe Ser Val Thr Ile Asp Ala Ile Pro Asp His His
      50                  55                  60                
 Pro Gly Glu Glu Ile Phe Asn Phe Leu Asn Ser Gly Lys Ile Phe Asn
  65                  70                  75                  80
 Gln Tyr Thr Leu Asp Leu Arg Asp Ser Gly Phe Ile Gly Gln Ser Ala
                  85                  90                  95    
 Val Glu Lys Leu Ile Leu Lys Ser Gly Lys Thr Asp Gln Ile Phe Leu
             100                 105                 110        
 Thr Thr Gln Gly Phe Leu Thr Ser Ala Tyr His Tyr Val Gln Cys Pro
         115                 120                 125            
 Val Pro Val Leu Lys Trp Leu Phe Arg Met Met Ser Val His Thr Asp
     130                 135                 140                
 Cys Ile Val Ser Val Gln Ile Leu Ser Thr Leu Met Glu Ile Thr Ile
 145                 150                 155                 160
 Arg Asn Asp Thr Phe Ser Asp Ser Pro Val Trp Pro Trp Ile Pro Ser
                 165                 170                 175    
 Leu Ser Asp Val Ala Ala Val Phe Phe Asn Met Gly Ile Asp Phe Arg
             180                 185                 190        
 Ser Leu Phe Pro Leu Glu Asn Leu Gln Pro Asp Phe Asn Glu Asp Tyr
         195                 200                 205            
 Leu Val Ser Glu Thr Gln Thr Thr Ser Arg Gly Lys Glu Ser Glu Asp
     210                 215                 220                
 Ser Ser Tyr Lys Pro Ile Phe Ser Thr Leu Pro Glu Thr Asn Ile Leu
 225                 230                 235                 240
 Asn Val Val Lys Phe Leu Gly Leu Cys Thr Ser Ile His Pro Glu Gly
                 245                 250                 255    
 Tyr Gln Asp Arg Glu Ile Met Leu Leu Ile Leu Met Leu Phe Lys Met
             260                 265                 270        
 Ser Leu Glu Lys Gln Leu Lys Gln Ile Pro Leu Val Asp Phe Gln Ser
         275                 280                 285            
 Leu Leu Ile Asn Leu Met Lys Asn Ile Arg Asp Trp Asn Thr Lys Val
     290                 295                 300                
 Pro Glu Leu Cys Leu Gly Ile Asn Glu Leu Ser Ser His Pro His Asn
 305                 310                 315                 320
 Leu Leu Trp Leu Val Gln Leu Val Pro Asn Trp Thr Ser Arg Gly Arg
                 325                 330                 335    
 Gln Leu Arg Gln Cys Leu Ser Leu Val Ile Ile Ser Lys Leu Leu Asp
             340                 345                 350        
 Glu Lys His Glu Asp Val Pro Asn Ala Ser Asn Leu Gln Ala Tyr Tyr
         355                 360                 365            
 Leu Thr Tyr Ile Leu Leu His Leu Val Gly Glu Val Ser Cys Ser His
     370                 375                 380                
 Ser Phe Ser Ser Gly Gln Arg Lys His Phe Val Leu Leu Cys Gly Ala
 385                 390                 395                 400
 Leu Glu Lys His Val Lys Cys Asp Ile Arg Glu Asp Ala Arg Leu Phe
                 405                 410                 415    
 Tyr Arg Thr Lys Val Lys Asp Leu Val Ala Arg Ile His Gly Lys Trp
             420                 425                 430        
 Gln Glu Ile Ile Gln Asn Cys Arg Pro Thr Gln Gly Gln Leu His Asp
         435                 440                 445            
 Phe Trp Val Pro Asp Ser
     450                



      <210> 497
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 497
 Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser
   1               5                  10                  15    
 Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser
              20                  25                  30        
 Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser
          35                  40                  45            
 Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe
      50                  55                  60                
 Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp
  65                  70                  75                  80
 Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu
                  85                  90                  95    
 Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg
             100                 105                 110        
 Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly
         115                 120                 125            
 Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly
     130                 135                 140                
 Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val
 145                 150                 155                 160
 Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr
                 165                 170                 175    
 Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu
             180                 185                 190        
 Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu
         195                 200                 205            
 Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser
     210                 215                 220                
 Glu Gln Leu Leu Ile Glu Glu Cys
 225                 230        



      <210> 498
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 498
 Met Ala Asn Pro Lys Leu Leu Gly Leu Glu Leu Ser Glu Ala Glu Ala
   1               5                  10                  15    
 Ile Gly Ala Asp Ser Ala Arg Phe Glu Glu Leu Leu Leu Gln Ala Ser
              20                  25                  30        
 Lys Glu Leu Gln Gln Ala Gln Thr Thr Arg Pro Glu Ser Thr Gln Ile
          35                  40                  45            
 Gln Pro Gln Pro Gly Phe Cys Ile Lys Thr Asn Ser Ser Glu Gly Lys
      50                  55                  60                
 Val Phe Ile Asn Ile Cys His Ser Pro Ser Ile Pro Pro Pro Ala Asp
  65                  70                  75                  80
 Val Thr Glu Glu Glu Leu Leu Gln Met Leu Glu Glu Asp Gln Ala Gly
                  85                  90                  95    
 Phe Arg Ile Pro Met Ser Leu Gly Glu Pro His Ala Glu Leu Asp Ala
             100                 105                 110        
 Lys Gly Gln Gly Cys Thr Ala Tyr Asp Val Ala Val Asn Ser Asp Phe
         115                 120                 125            
 Tyr Arg Arg Met Gln Asn Ser Asp Phe Leu Arg Glu Leu Val Ile Thr
     130                 135                 140                
 Ile Ala Arg Glu Gly Leu Glu Asp Lys Tyr Asn Leu Gln Leu Asn Pro
 145                 150                 155                 160
 Glu Trp Arg Met Met Lys Asn Arg Pro Phe Met Gly Ser Ile Ser Gln
                 165                 170                 175    
 Gln Asn Ile Arg Ser Glu Gln Arg Pro Arg Ile Gln Glu Leu Gly Asp
             180                 185                 190        
 Leu Tyr Thr Pro Ala Pro Gly Arg Ala Glu Ser Gly Pro Glu Lys Pro
         195                 200                 205            
 His Leu Asn Leu Trp Leu Glu Ala Pro Asp Leu Leu Leu Ala Glu Val
     210                 215                 220                
 Asp Leu Pro Lys Leu Asp Gly Ala Leu Gly Leu Ser Leu Glu Ile Gly
 225                 230                 235                 240
 Glu Asn Arg Leu Val Met Gly Gly Pro Gln Gln Leu Tyr His Leu Asp
                 245                 250                 255    
 Ala Tyr Ile Pro Leu Gln Ile Asn Ser His Glu Ser Lys Ala Ala Phe
             260                 265                 270        
 His Arg Lys Arg Lys Gln Leu Met Val Ala Met Pro Leu Leu Pro Val
         275                 280                 285            
 Pro Ser
     290



      <210> 499
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 499
 Met Leu Arg Trp Leu Ile Gly Gly Gly Arg Glu Pro Gln Gly Leu Ala
   1               5                  10                  15    
 Glu Lys Ser Pro Leu Gln Thr Ile Gly Glu Glu Gln Thr Gln Asn Pro
              20                  25                  30        
 Tyr Thr Glu Leu Leu Val Leu Lys Ala His His Asp Ile Val Arg Phe
          35                  40                  45            
 Leu Val Gln Leu Asp Asp Tyr Arg Phe Ala Ser Ala Gly Asp Asp Gly
      50                  55                  60                
 Ile Val Val Val Trp Asn Ala Gln Thr Gly Glu Lys Leu Leu Glu Leu
  65                  70                  75                  80
 Asn Gly His Thr Gln Lys Ile Thr Ala Ile Ile Thr Phe Pro Ser Leu
                  85                  90                  95    
 Glu Ser Cys Glu Glu Lys Asn Gln Leu Ile Leu Thr Ala Ser Ala Asp
             100                 105                 110        
 Arg Thr Val Ile Val Trp Asp Gly Asp Thr Thr Arg Gln Val Gln Arg
         115                 120                 125            
 Ile Ser Cys Phe Gln Ser Thr Val Lys Cys Leu Thr Val Leu Gln Arg
     130                 135                 140                
 Leu Asp Val Trp Leu Ser Gly Gly Asn Asp Leu Cys Val Trp Asn Arg
 145                 150                 155                 160
 Lys Leu Asp Leu Leu Cys Lys Thr Ser His Leu Ser Asp Thr Gly Ile
                 165                 170                 175    
 Ser Ala Leu Val Glu Ile Pro Lys Asn Cys Val Val Ala Ala Val Gly
             180                 185                 190        
 Lys Glu Leu Ile Ile Phe Arg Leu Val Ala Pro Thr Glu Gly Ser Leu
         195                 200                 205            
 Glu Trp Asp Ile Leu Glu Val Lys Arg Leu Leu Asp His Gln Asp Asn
     210                 215                 220                
 Ile Leu Ser Leu Ile Asn Val Asn Asp Leu Ser Phe Val Thr Gly Ser
 225                 230                 235                 240
 His Val Gly Glu Leu Ile Ile Trp Asp Ala Leu Asp Trp Thr Met Gln
                 245                 250                 255    
 Ala Tyr Glu Arg Asn Phe Trp Asp Pro Ser Pro Gln Leu Asp Thr Gln
             260                 265                 270        
 Gln Glu Ile Lys Leu Cys Gln Lys Ser Asn Asp Ile Ser Ile His His
         275                 280                 285            
 Phe Thr Cys Asp Glu Glu Asn Val Phe Ala Ala Val Gly Arg Gly Leu
     290                 295                 300                
 Tyr Val Tyr Ser Leu Gln Met Lys Arg Val Ile Ala Cys Gln Lys Thr
 305                 310                 315                 320
 Ala His Asp Ser Asn Val Leu His Ile Ala Arg Leu Pro Asn Arg Gln
                 325                 330                 335    
 Leu Ile Ser Cys Ser Glu Asp Gly Ser Val Arg Ile Trp Glu Leu Arg
             340                 345                 350        
 Glu Lys Gln Gln Leu Ala Ala Glu Pro Val Pro Thr Gly Phe Phe Asn
         355                 360                 365            
 Met Trp Gly Phe Gly Arg Val Ser Lys Gln Ala Ser Gln Pro Val Lys
     370                 375                 380                
 Lys Gln Gln Glu Asn Ala Thr Ser Cys Ser Leu Glu Leu Ile Gly Asp
 385                 390                 395                 400
 Leu Ile Gly His Ser Ser Ser Val Glu Met Phe Leu Tyr Phe Glu Asp
                 405                 410                 415    
 His Gly Leu Val Thr Cys Ser Ala Asp His Leu Ile Ile Leu Trp Lys
             420                 425                 430        
 Asn Gly Glu Arg Glu Ser Gly Leu Arg Ser Leu Arg Leu Phe Gln Lys
         435                 440                 445            
 Leu Glu Glu Asn Gly Asp Leu Tyr Leu Ala Val
     450                 455                



      <210> 500
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 500
 Met Gly Gln Gly Leu Trp Arg Val Val Arg Asn Gln Gln Leu Gln Gln
   1               5                  10                  15    
 Glu Gly Tyr Ser Glu Gln Gly Tyr Leu Thr Arg Glu Gln Ser Arg Arg
              20                  25                  30        
 Met Ala Ala Ser Asn Ile Ser Asn Thr Asn His Arg Lys Gln Val Gln
          35                  40                  45            
 Gly Gly Ile Asp Ile Tyr His Leu Leu Lys Ala Arg Lys Ser Lys Glu
      50                  55                  60                
 Gln Glu Gly Phe Ile Asn Leu Glu Met Leu Pro Pro Glu Leu Ser Phe
  65                  70                  75                  80
 Thr Ile Leu Ser Tyr Leu Asn Ala Thr Asp Leu Cys Leu Ala Ser Cys
                  85                  90                  95    
 Val Trp Gln Asp Leu Ala Asn Asp Glu Leu Leu Trp Gln Gly Leu Cys
             100                 105                 110        
 Lys Ser Thr Trp Gly His Cys Ser Ile Tyr Asn Lys Asn Pro Pro Leu
         115                 120                 125            
 Gly Phe Ser Phe Arg Lys Leu Tyr Met Gln Leu Asp Glu Gly Ser Leu
     130                 135                 140                
 Thr Phe Asn Ala Asn Pro Asp Glu Gly Val Asn Tyr Phe Met Ser Lys
 145                 150                 155                 160
 Gly Ile Leu Asp Asp Ser Pro Lys Glu Ile Ala Lys Phe Ile Phe Cys
                 165                 170                 175    
 Thr Arg Thr Leu Asn Trp Lys Lys Leu Arg Ile Tyr Leu Asp Glu Arg
             180                 185                 190        
 Arg Asp Val Leu Asp Asp Leu Val Thr Leu His Asn Phe Arg Asn Gln
         195                 200                 205            
 Phe Leu Pro Asn Ala Leu Arg Glu Phe Phe Arg His Ile His Ala Pro
     210                 215                 220                
 Glu Glu Arg Gly Glu Tyr Leu Glu Thr Leu Ile Thr Lys Phe Ser His
 225                 230                 235                 240
 Arg Phe Cys Ala Cys Asn Pro Asp Leu Met Arg Glu Leu Gly Leu Ser
                 245                 250                 255    
 Pro Asp Ala Val Tyr Val Leu Cys Tyr Ser Leu Ile Leu Leu Ser Ile
             260                 265                 270        
 Asp Leu Thr Ser Pro His Val Lys Asn Lys Met Ser Lys Arg Glu Phe
         275                 280                 285            
 Ile Arg Asn Thr Arg Arg Ala Ala Gln Asn Ile Ser Glu Asp Phe Val
     290                 295                 300                
 Gly His Leu Tyr Asp Asn Ile Tyr Leu Ile Gly His Val Ala Ala
 305                 310                 315                



      <210> 501
      <211> 354
      <212> PRT
      <213> Homo sapiens


      <400> 501
 Met Ala Thr Pro Leu Val Ala Gly Pro Ala Ala Leu Arg Phe Ala Ala
   1               5                  10                  15    
 Ala Ala Ser Trp Gln Val Val Arg Gly Arg Cys Val Glu His Phe Pro
              20                  25                  30        
 Arg Val Leu Glu Phe Leu Arg Ser Leu Arg Ala Val Ala Pro Gly Leu
          35                  40                  45            
 Val Arg Tyr Arg His His Glu Arg Leu Cys Met Gly Leu Lys Ala Lys
      50                  55                  60                
 Val Val Val Glu Leu Ile Leu Gln Gly Arg Pro Trp Ala Gln Val Leu
  65                  70                  75                  80
 Lys Ala Leu Asn His His Phe Pro Glu Ser Gly Pro Ile Val Arg Asp
                  85                  90                  95    
 Pro Lys Ala Thr Lys Gln Asp Leu Arg Lys Ile Leu Glu Ala Gln Glu
             100                 105                 110        
 Thr Phe Tyr Gln Gln Val Lys Gln Leu Ser Glu Ala Pro Val Asp Leu
         115                 120                 125            
 Ala Ser Lys Leu Gln Glu Leu Glu Gln Glu Tyr Gly Glu Pro Phe Leu
     130                 135                 140                
 Ala Ala Met Glu Lys Leu Leu Phe Glu Tyr Leu Cys Gln Leu Glu Lys
 145                 150                 155                 160
 Ala Leu Pro Thr Pro Gln Ala Gln Gln Leu Gln Asp Val Leu Ser Trp
                 165                 170                 175    
 Met Gln Pro Gly Val Ser Ile Thr Ser Ser Leu Ala Trp Arg Gln Tyr
             180                 185                 190        
 Gly Val Asp Met Gly Trp Leu Leu Pro Glu Cys Ser Val Thr Asp Ser
         195                 200                 205            
 Val Asn Leu Ala Glu Pro Met Glu Gln Asn Pro Pro Gln Gln Gln Arg
     210                 215                 220                
 Leu Ala Leu His Asn Pro Leu Pro Lys Ala Lys Pro Gly Thr His Leu
 225                 230                 235                 240
 Pro Gln Gly Pro Ser Ser Arg Thr His Pro Glu Pro Leu Ala Gly Arg
                 245                 250                 255    
 His Phe Asn Leu Ala Pro Leu Gly Arg Arg Arg Val Gln Ser Gln Trp
             260                 265                 270        
 Ala Ser Thr Arg Gly Gly His Lys Glu Arg Pro Thr Val Met Leu Phe
         275                 280                 285            
 Pro Phe Arg Asn Leu Gly Ser Pro Thr Gln Val Ile Ser Lys Pro Glu
     290                 295                 300                
 Ser Lys Glu Glu His Ala Ile Tyr Thr Ala Asp Leu Ala Met Gly Thr
 305                 310                 315                 320
 Arg Ala Ala Ser Thr Gly Lys Ser Lys Ser Pro Cys Gln Thr Leu Gly
                 325                 330                 335    
 Gly Arg Ala Leu Lys Glu Asn Pro Val Asp Leu Pro Ala Thr Glu Gln
             340                 345                 350        
 Lys Glu
        



      <210> 502
      <211> 642
      <212> PRT
      <213> Homo sapiens


      <400> 502
 Met Leu Leu Asp Gln Leu Arg Ser His Cys Thr Val Lys Asp Pro Glu
   1               5                  10                  15    
 Ser Leu Leu Val Pro Ala Pro Leu Ser Gly Pro Arg Arg Tyr Gln Val
              20                  25                  30        
 Met Arg Gln His Ser Arg Gln Gln Leu Ser Phe His Ile Asp Ser Ser
          35                  40                  45            
 Ser Ser Ser Ser Ser Gly Gln Leu Val Asp Phe Thr Leu Arg Glu Phe
      50                  55                  60                
 Leu Trp Gln His Val Glu Leu Val Leu Ser Lys Lys Gly Phe Asp Asp
  65                  70                  75                  80
 Ser Val Gly Arg Asn Pro Gln Pro Ser His Phe Glu Leu Pro Thr Tyr
                  85                  90                  95    
 Gln Lys Trp Ile Ser Ala Ala Ser Lys Leu Tyr Glu Val Ala Ile Asp
             100                 105                 110        
 Gly Lys Glu Glu Asp Leu Gly Ser Pro Thr Gly Glu Leu Thr Ser Lys
         115                 120                 125            
 Ile Leu Ser Ser Ile Lys Val Leu Glu Gly Phe Leu Asp Ile Asp Thr
     130                 135                 140                
 Lys Phe Ser Glu Asn Arg Cys Gln Lys Ala Leu Pro Met Ala His Ser
 145                 150                 155                 160
 Ala Tyr Gln Ser Asn Leu Pro His Asn Tyr Thr Met Thr Val His Lys
                 165                 170                 175    
 Asn Gln Leu Ala Gln Ala Leu Arg Val Tyr Ser Gln His Ala Arg Gly
             180                 185                 190        
 Pro Ala Phe His Lys Tyr Ala Met Gln Leu His Glu Asp Cys Tyr Lys
         195                 200                 205            
 Phe Trp Ser Asn Gly His Gln Leu Cys Glu Glu Arg Ser Leu Thr Asp
     210                 215                 220                
 Gln His Cys Val His Lys Phe His Ser Leu Pro Lys Ser Gly Glu Lys
 225                 230                 235                 240
 Pro Glu Ala Asp Arg Asn Pro Pro Val Leu Tyr His Asn Ser Arg Ala
                 245                 250                 255    
 Arg Ser Thr Gly Ala Cys Asn Cys Gly Arg Lys Gln Ala Pro Arg Asp
             260                 265                 270        
 Asp Pro Phe Asp Ile Lys Ala Ala Asn Tyr Asp Phe Tyr Gln Leu Leu
         275                 280                 285            
 Glu Glu Lys Cys Cys Gly Lys Leu Asp His Ile Asn Phe Pro Val Phe
     290                 295                 300                
 Glu Pro Ser Thr Pro Asp Pro Ala Pro Ala Lys Asn Glu Ser Ser Pro
 305                 310                 315                 320
 Ala Pro Pro Asp Ser Asp Ala Asp Lys Leu Lys Glu Lys Glu Pro Gln
                 325                 330                 335    
 Thr Gln Gly Glu Ser Thr Ser Leu Ser Leu Ala Leu Ser Leu Gly Gln
             340                 345                 350        
 Ser Thr Asp Ser Leu Gly Thr Tyr Pro Ala Asp Pro Gln Ala Gly Gly
         355                 360                 365            
 Asp Asn Pro Glu Val His Gly Gln Val Glu Val Lys Thr Glu Lys Arg
     370                 375                 380                
 Pro Asn Phe Val Asp Arg Gln Ala Ser Thr Val Glu Tyr Leu Pro Gly
 385                 390                 395                 400
 Met Leu His Ser Asn Cys Pro Lys Gly Leu Leu Pro Lys Phe Ser Ser
                 405                 410                 415    
 Trp Ser Leu Val Lys Leu Gly Pro Ala Lys Ser Tyr Asn Phe His Thr
             420                 425                 430        
 Gly Leu Asp Gln Gln Gly Phe Ile Pro Gly Thr Asn Tyr Leu Met Pro
         435                 440                 445            
 Trp Asp Ile Val Ile Arg Thr Arg Ala Glu Asp Glu Gly Asp Leu Asp
     450                 455                 460                
 Thr Asn Ser Trp Pro Ala Pro Asn Lys Ala Ile Pro Gly Lys Arg Ser
 465                 470                 475                 480
 Ala Val Val Met Gly Arg Gly Arg Arg Arg Asp Asp Ile Ala Arg Ala
                 485                 490                 495    
 Phe Val Gly Phe Glu Tyr Glu Asp Ser Arg Gly Arg Arg Phe Met Cys
             500                 505                 510        
 Ser Gly Pro Asp Lys Val Met Lys Val Met Gly Ser Gly Pro Lys Glu
         515                 520                 525            
 Ser Ala Leu Lys Ala Leu Asn Ser Asp Met Pro Leu Tyr Ile Leu Ser
     530                 535                 540                
 Ser Ser Gln Gly Arg Gly Leu Lys Pro His Tyr Ala Gln Leu Met Arg
 545                 550                 555                 560
 Leu Phe Val Val Val Pro Asp Ala Pro Leu Gln Ile Ile Leu Met Pro
                 565                 570                 575    
 Gln Val Gln Pro Gly Pro Pro Pro Cys Pro Val Phe Tyr Pro Glu Lys
             580                 585                 590        
 Gln Glu Ile Thr Leu Pro Pro Asp Gly Leu Trp Val Leu Arg Phe Pro
         595                 600                 605            
 Tyr Ala Tyr Val Thr Glu Arg Gly Pro Cys Phe Pro Pro Lys Glu Asn
     610                 615                 620                
 Val Gln Leu Met Ser Tyr Lys Val Leu Arg Gly Val Leu Lys Ala Val
 625                 630                 635                 640
 Thr Gln
        



      <210> 503
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 503
 Met Ser Gln Val Thr Phe Ser Asp Val Ala Ile Asp Phe Ser His Glu
   1               5                  10                  15    
 Glu Trp Ala Cys Leu Asp Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val
              20                  25                  30        
 Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Gly Leu Ser Val Thr
          35                  40                  45            
 Lys Pro Tyr Val Ile Met Leu Leu Glu Asp Gly Lys Glu Pro Trp Met
      50                  55                  60                
 Met Glu Lys Lys Leu Ser Lys Asp Trp Glu Ser Arg Trp Glu Asn Lys
  65                  70                  75                  80
 Glu Leu Ser Thr Lys Lys Asp Ile Tyr Asp Glu Asp Ser Pro Gln Pro
                  85                  90                  95    
 Val Thr Met Glu Lys Val Val Lys Gln Ser Tyr Glu Phe Ser Asn Ser
             100                 105                 110        
 Asn Lys Asn Leu Glu Tyr Thr Glu Cys Asp Thr Phe Arg Ser Thr Phe
         115                 120                 125            
 His Ser Lys Ser Thr Leu Ser Glu Pro Gln Asn Asn Ser Ala Glu Gly
     130                 135                 140                
 Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu Ser Lys Lys Ser
 145                 150                 155                 160
 Val Ile Lys Ser Glu Arg Ile Asn Gly Gly Lys Lys Leu Leu Asn Ser
                 165                 170                 175    
 Asn Lys Ser Gly Ala Ala Phe Asn Gln Ser Lys Ser Leu Thr Leu Pro
             180                 185                 190        
 Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser Glu Cys Gly Lys
         195                 200                 205            
 Ala Phe Gly Lys Gln Ser Ile Leu Ser Arg His Trp Arg Ile His Thr
     210                 215                 220                
 Gly Glu Lys Pro Tyr Glu Cys Arg Glu Phe Gly Lys Thr Phe Ser His
 225                 230                 235                 240
 Gly Ser Ser Leu Thr Arg His Gln Ile Ser His Ser Gly Glu Lys Pro
                 245                 250                 255    
 Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His Gly Ser Ser Leu
             260                 265                 270        
 Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Met
         275                 280                 285            
 Asn Cys Gly Lys Ser Phe Ser Arg Val Ser Leu Leu Ile Gln His Leu
     290                 295                 300                
 Arg Ile His Thr Gln Glu Lys Arg Tyr Glu Cys Arg Ile Cys Gly Lys
 305                 310                 315                 320
 Ala Phe Ile His Ser Ser Ser Leu Ile His His Gln Lys Ser His Thr
                 325                 330                 335    
 Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe Cys Cys
             340                 345                 350        
 Ser Ser His Leu Thr Gln His Gln Arg Ile His Ser Met Lys Lys Lys
         355                 360                 365            
 Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser Phe Ser Phe Leu
     370                 375                 380                
 Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro Phe Glu Val
 385                 390                 395                



      <210> 504
      <211> 263
      <212> PRT
      <213> Homo sapiens


      <400> 504
 Met Glu Ser Trp Ala Leu Ala Val Phe Pro Glu Tyr Arg Val Ser Leu
   1               5                  10                  15    
 Leu Trp Cys Leu Glu Leu Ala Ser Pro Leu Trp Ser Leu Gly Gln Ala
              20                  25                  30        
 Pro Pro Leu His Glu Thr Trp Phe Val Gly His Thr Trp Phe Gln Gly
          35                  40                  45            
 Arg Gly Lys Arg Ser Pro Arg Ala Glu Val Ser Arg Pro Glu Pro Gly
      50                  55                  60                
 Ala Pro Leu Leu Gly Cys Trp Leu Gln Trp Gly Ala Pro Ser Pro Gly
  65                  70                  75                  80
 Pro Leu Cys Leu Leu Phe Arg Leu Cys Ser Cys Thr Cys Phe Ala Pro
                  85                  90                  95    
 Leu Pro Ala Gly Ala Asp Met Asp Pro Asn Pro Arg Ala Ala Leu Glu
             100                 105                 110        
 Arg Gln Gln Leu Arg Leu Arg Glu Arg Gln Lys Phe Phe Glu Asp Ile
         115                 120                 125            
 Leu Gln Pro Glu Thr Glu Phe Val Phe Pro Leu Ser His Leu His Leu
     130                 135                 140                
 Glu Ser Gln Arg Pro Pro Ile Gly Ser Ile Ser Ser Met Glu Val Asn
 145                 150                 155                 160
 Val Asp Thr Leu Glu Gln Val Glu Leu Ile Asp Leu Gly Asp Pro Asp
                 165                 170                 175    
 Ala Ala Asp Val Phe Leu Pro Cys Glu Asp Pro Pro Pro Thr Pro Gln
             180                 185                 190        
 Ser Ser Gly Val Asp Asn His Leu Glu Glu Leu Ser Leu Pro Val Ala
         195                 200                 205            
 Thr Ser Asp Arg Thr Thr Ser Arg Thr Ser Ser Ser Ser Ser Ser Asp
     210                 215                 220                
 Ser Ser Thr Asn Leu His Ser Pro Asn Pro Ser Asp Asp Gly Ala Asp
 225                 230                 235                 240
 Thr Pro Leu Ala Gln Ser Asp Glu Glu Glu Glu Arg Gly Asp Gly Gly
                 245                 250                 255    
 Ala Glu Pro Gly Ala Cys Ser
             260            



      <210> 505
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 505
 Met Asp Asn Pro Thr Phe Ala Glu Asp Glu Glu Leu Gln Asn Met Asp
   1               5                  10                  15    
 Lys Glu Asp Ala Leu Ile Cys Phe Glu Glu His Ile Arg Ala Leu Glu
              20                  25                  30        
 Lys Glu Glu Glu Glu Glu Lys Gln Lys Ser Leu Leu Arg Glu Arg Arg
          35                  40                  45            
 Arg Gln Arg Lys Asn Arg Glu Ser Phe Gln Ile Phe Leu Asp Glu Leu
      50                  55                  60                
 His Glu His Gly Gln Leu His Ser Met Ser Ser Trp Met Glu Leu Tyr
  65                  70                  75                  80
 Pro Thr Ile Ser Ser Asp Ile Arg Phe Thr Asn Met Leu Gly Gln Pro
                  85                  90                  95    
 Val Phe Ser Leu Gly Ser Thr Ala Leu Asp Leu Phe Lys Phe Tyr Val
             100                 105                 110        
 Glu Asp Leu Lys Ala Arg Tyr His Asp Glu Lys Lys Ile Ile Lys Asp
         115                 120                 125            
 Ile Leu Lys Asp Lys Gly Phe Val Val Glu Val Asn Thr Thr Phe Glu
     130                 135                 140                
 Asp Phe Val Ala Ile Ile Ser Ser Thr Lys Arg Ser Thr Thr Leu Asp
 145                 150                 155                 160
 Ala Gly Asn Ile Lys Leu Ala Phe Asn Ser Leu Leu Glu Lys Ala Glu
                 165                 170                 175    
 Ala Arg Glu Arg Glu Arg Glu Lys Glu Glu Ala Arg Lys Met Lys Arg
             180                 185                 190        
 Lys Glu Ser Ala Phe Lys Ser Met Leu Lys Gln Ala Ala Pro Pro Ile
         195                 200                 205            
 Glu Leu Asp Ala Val Trp Glu Asp Ile Arg Glu Arg Phe Val Lys Glu
     210                 215                 220                
 Pro Ala Phe Glu Asp Ile Thr Leu Glu Ser Glu Arg Lys Arg Ile Phe
 225                 230                 235                 240
 Lys Asp Phe Met His Val Leu Glu His Glu Cys Gln His His His Ser
                 245                 250                 255    
 Lys Asn Lys Lys His Ser Lys Lys Ser Lys Lys His His Arg Lys Arg
             260                 265                 270        
 Ser Arg Ser Arg Ser Gly Ser Asp Ser Asp Asp Asp Asp Ser His Ser
         275                 280                 285            
 Lys Lys Lys Arg Gln Arg Ser Glu Ser Arg Ser Ala Ser Glu His Ser
     290                 295                 300                
 Ser Ser Ala Glu Ser Glu Arg Ser Tyr Lys Lys Ser Lys Lys His Lys
 305                 310                 315                 320
 Lys Lys Ser Lys Lys Arg Arg His Lys Ser Asp Ser Pro Glu Ser Asp
                 325                 330                 335    
 Ala Glu Arg Glu Lys Asp Lys Lys Glu Lys Asp Arg Glu Ser Glu Lys
             340                 345                 350        
 Asp Arg Thr Arg Gln Arg Ser Glu Ser Lys His Lys Ser Pro Lys Lys
         355                 360                 365            
 Lys Thr Gly Lys Asp Ser Gly Asn Trp Asp Thr Ser Gly Ser Glu Leu
     370                 375                 380                
 Ser Glu Gly Glu Leu Glu Lys Arg Arg Arg Thr Leu Leu Glu Gln Leu
 385                 390                 395                 400
 Asp Asp Asp Gln
                



      <210> 506
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 506
 Met Ala Glu Ala Val Leu Arg Val Ala Arg Arg Gln Leu Ser Gln Arg
   1               5                  10                  15    
 Gly Gly Ser Gly Ala Pro Ile Leu Leu Arg Gln Met Phe Glu Pro Val
              20                  25                  30        
 Ser Cys Thr Phe Thr Tyr Leu Leu Gly Asp Arg Glu Ser Arg Glu Ala
          35                  40                  45            
 Val Leu Ile Asp Pro Val Leu Glu Thr Ala Pro Arg Asp Ala Gln Leu
      50                  55                  60                
 Ile Lys Glu Leu Gly Leu Arg Leu Leu Tyr Ala Val Asn Thr His Cys
  65                  70                  75                  80
 His Ala Asp His Ile Thr Gly Ser Gly Leu Leu Arg Ser Leu Leu Pro
                  85                  90                  95    
 Gly Cys Gln Ser Val Ile Ser Arg Leu Ser Gly Ala Gln Ala Asp Leu
             100                 105                 110        
 His Ile Glu Asp Gly Asp Ser Ile Arg Phe Gly Arg Phe Ala Leu Glu
         115                 120                 125            
 Thr Arg Ala Ser Pro Gly His Thr Pro Gly Cys Val Thr Phe Val Leu
     130                 135                 140                
 Asn Asp His Ser Met Ala Phe Thr Gly Asp Ala Leu Leu Ile Arg Gly
 145                 150                 155                 160
 Cys Gly Arg Thr Asp Phe Gln Gln Gly Cys Ala Lys Thr Leu Tyr His
                 165                 170                 175    
 Ser Val His Glu Lys Ile Phe Thr Leu Pro Gly Asp Cys Leu Ile Tyr
             180                 185                 190        
 Pro Ala His Asp Tyr His Gly Phe Thr Val Ser Thr Val Glu Glu Glu
         195                 200                 205            
 Arg Thr Leu Asn Pro Arg Leu Thr Leu Ser Cys Glu Glu Phe Val Lys
     210                 215                 220                
 Ile Met Gly Asn Leu Asn Leu Pro Lys Pro Gln Gln Ile Asp Phe Ala
 225                 230                 235                 240
 Val Pro Ala Asn Met Arg Cys Gly Val Gln Thr Pro Thr Ala
                 245                 250                



      <210> 507
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 507
 Met Glu Thr Glu Thr Ala Pro Leu Thr Leu Glu Ser Leu Pro Thr Asp
   1               5                  10                  15    
 Pro Leu Leu Leu Ile Leu Ser Phe Leu Asp Tyr Arg Asp Leu Ile Asn
              20                  25                  30        
 Cys Cys Tyr Val Ser Arg Arg Leu Ser Gln Leu Ser Ser His Asp Pro
          35                  40                  45            
 Leu Trp Arg Arg His Cys Lys Lys Tyr Trp Leu Ile Ser Glu Glu Glu
      50                  55                  60                
 Lys Thr Gln Lys Asn Gln Cys Trp Lys Ser Leu Phe Ile Asp Thr Tyr
  65                  70                  75                  80
 Ser Asp Val Gly Arg Tyr Ile Asp His Tyr Ala Ala Ile Lys Lys Ala
                  85                  90                  95    
 Trp Asp Asp Leu Lys Lys Tyr Leu Glu Pro Arg Cys Pro Arg Met Val
             100                 105                 110        
 Leu Ser Leu Lys Glu Gly Ala Arg Glu Glu Asp Leu Asp Ala Val Glu
         115                 120                 125            
 Ala Gln Ile Gly Cys Lys Leu Pro Asp Asp Tyr Arg Cys Ser Tyr Arg
     130                 135                 140                
 Ile His Asn Gly Gln Lys Leu Val Val Pro Gly Leu Leu Gly Ser Met
 145                 150                 155                 160
 Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu Leu Asp Val Asp Thr
                 165                 170                 175    
 Ala Ala Gly Gly Phe Gln Gln Arg Gln Gly Leu Lys Tyr Cys Leu Pro
             180                 185                 190        
 Leu Thr Phe Cys Ile His Thr Gly Leu Ser Gln Tyr Ile Ala Val Glu
         195                 200                 205            
 Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe Tyr Gln Cys Pro Asp
     210                 215                 220                
 Gln Met Ala Arg Asn Pro Ala Ala Ile Asp Met Phe Ile Ile Gly Ala
 225                 230                 235                 240
 Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Lys Asn Val Val Ser Gly
                 245                 250                 255    
 Gly Phe Pro Ile Ile Arg Asp Gln Ile Phe Arg Tyr Val His Asp Pro
             260                 265                 270        
 Glu Cys Val Ala Thr Thr Gly Asp Ile Thr Val Ser Val Ser Thr Ser
         275                 280                 285            
 Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro His Tyr Phe Phe Thr
     290                 295                 300                
 Tyr Arg Ile Arg Ile Glu Met Ser Lys Asp Ala Leu Pro Glu Lys Ala
 305                 310                 315                 320
 Cys Gln Leu Asp Ser Arg Tyr Trp Arg Ile Thr Asn Ala Lys Gly Asp
                 325                 330                 335    
 Val Glu Glu Val Gln Gly Pro Gly Val Val Gly Glu Phe Pro Ile Ile
             340                 345                 350        
 Ser Pro Gly Arg Val Tyr Glu Tyr Thr Ser Cys Thr Thr Phe Ser Thr
         355                 360                 365            
 Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe His Phe Leu Tyr Phe
     370                 375                 380                
 Lys Asp Lys Ile Phe Asn Val Ala Ile Pro Arg Phe His Met Ala Cys
 385                 390                 395                 400
 Pro Thr Phe Arg Val Ser Ile Ala Arg Leu Glu Met Gly Pro Asp Glu
                 405                 410                 415    
 Tyr Glu Glu Met Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu
             420                 425                 430        
 Asp Asp Asp Ser Ala Asp Met Asp Glu Ser Asp Glu Asp Asp Glu Glu
         435                 440                 445            
 Glu Arg Arg Arg Arg Val Phe Asp Val Pro Ile Arg Arg Arg Arg Cys
     450                 455                 460                
 Ser Arg Leu Phe
 465            



      <210> 508
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 508
 Met Pro Val Ala Arg Ser Trp Val Cys Arg Lys Thr Tyr Val Thr Pro
   1               5                  10                  15    
 Arg Arg Pro Phe Glu Lys Ser Arg Leu Asp Gln Glu Leu Lys Leu Ile
              20                  25                  30        
 Gly Glu Tyr Gly Leu Arg Asn Lys Arg Glu Val Trp Arg Val Lys Phe
          35                  40                  45            
 Thr Leu Ala Lys Ile Arg Lys Ala Ala Arg Glu Leu Leu Thr Leu Asp
      50                  55                  60                
 Glu Lys Asp Pro Arg Arg Leu Phe Glu Gly Asn Ala Leu Leu Arg Arg
  65                  70                  75                  80
 Leu Val Arg Ile Gly Val Leu Asp Glu Gly Lys Met Lys Leu Asp Tyr
                  85                  90                  95    
 Ile Leu Gly Leu Lys Ile Glu Asp Phe Leu Glu Arg Arg Leu Gln Thr
             100                 105                 110        
 Gln Val Phe Lys Leu Gly Leu Ala Lys Ser Ile His Ala Arg Val Leu
         115                 120                 125            
 Ile Arg Gln Arg His Ile Arg Val Arg Lys Gln Val Val Asn Ile Pro
     130                 135                 140                
 Ser Phe Ile Val Arg Leu Asp Ser Gln Lys His Ile Asp Phe Ser Leu
 145                 150                 155                 160
 Arg Ser Pro Tyr Gly Gly Gly Arg Pro Gly Arg Val Lys Arg Lys Asn
                 165                 170                 175    
 Ala Lys Lys Gly Gln Gly Gly Ala Gly Ala Gly Asp Asp Glu Glu Glu
             180                 185                 190        
 Asp
    



      <210> 509
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 509
 Met Ala Ala Glu Glu Glu Asp Glu Val Glu Trp Val Val Glu Ser Ile
   1               5                  10                  15    
 Ala Gly Phe Leu Arg Gly Pro Asp Trp Ser Ile Pro Ile Leu Asp Phe
              20                  25                  30        
 Val Glu Gln Lys Cys Glu Val Phe Asp Asp Glu Glu Glu Ser Lys Leu
          35                  40                  45            
 Thr Tyr Thr Glu Ile His Gln Glu Tyr Lys Glu Leu Val Glu Lys Leu
      50                  55                  60                
 Leu Glu Gly Tyr Leu Lys Glu Ile Gly Ile Asn Glu Asp Gln Phe Gln
  65                  70                  75                  80
 Glu Ala Cys Thr Ser Pro Leu Ala Lys Thr His Thr Ser Gln Ala Ile
                  85                  90                  95    
 Leu Gln Pro Val Leu Ala Ala Glu Asp Phe Thr Ile Phe Lys Ala Met
             100                 105                 110        
 Met Val Gln Lys Asn Ile Glu Met Gln Leu Gln Ala Ile Arg Ile Ile
         115                 120                 125            
 Gln Glu Arg Asn Gly Val Leu Pro Asp Cys Leu Thr Asp Gly Ser Asp
     130                 135                 140                
 Val Val Ser Asp Leu Glu His Glu Glu Met Lys Ile Leu Arg Glu Val
 145                 150                 155                 160
 Leu Arg Lys Ser Lys Glu Glu Tyr Asp Gln Glu Glu Lys Gly Glu Glu
                 165                 170                 175    
 Lys Gln Leu Ser Glu Ala Lys Gln Lys Glu Pro Thr Val His Ser Ser
             180                 185                 190        
 Glu Ala Ala Ile Met Asn Asn Ser Gln Gly Asp Gly Glu His Phe Ala
         195                 200                 205            
 His Pro Pro Ser Glu Val Lys Met His Phe Ala Asn Gln Ser Ile Glu
     210                 215                 220                
 Pro Leu Gly Arg Lys Val Glu Arg Ser Glu Thr Ser Ser Leu Pro Gln
 225                 230                 235                 240
 Lys Gly Leu Lys Ile Pro Gly Leu Glu His Ala Ser Ile Glu Gly Pro
                 245                 250                 255    
 Ile Ala Asn Leu Ser Val Leu Gly Thr Glu Glu Leu Arg Gln Arg Glu
             260                 265                 270        
 His Tyr Leu Lys Gln Lys Arg Asp Lys Leu Met Ser Met Arg Lys Asp
         275                 280                 285            
 Met Arg Thr Lys Gln Ile Gln Asn Met Glu Gln Lys Gly Lys Pro Thr
     290                 295                 300                
 Gly Glu Val Glu Glu Met Thr Glu Lys Pro Glu Met Thr Ala Glu Glu
 305                 310                 315                 320
 Lys Gln Thr Leu Leu Lys Arg Arg Leu Leu Ala Glu Lys Leu Lys Glu
                 325                 330                 335    
 Glu Val Ile Asn Lys
             340    



      <210> 510
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 510
 Met Ala Val Gly Lys Asn Lys Arg Leu Thr Lys Gly Gly Lys Lys Gly
   1               5                  10                  15    
 Ala Lys Lys Lys Val Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp
              20                  25                  30        
 Val Lys Ala Pro Ala Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Leu
          35                  40                  45            
 Val Thr Arg Thr Gln Gly Thr Lys Ile Ala Ser Asp Gly Leu Lys Gly
      50                  55                  60                
 Arg Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Val Ala
  65                  70                  75                  80
 Phe Arg Lys Phe Lys Leu Ile Thr Glu Asp Val Gln Gly Lys Asn Cys
                  85                  90                  95    
 Leu Thr Asn Phe His Gly Met Asp Leu Thr Arg Asp Lys Met Cys Ser
             100                 105                 110        
 Met Val Lys Lys Trp Gln Thr Met Ile Glu Ala His Val Asp Val Lys
         115                 120                 125            
 Thr Thr Asp Gly Tyr Leu Leu Arg Leu Phe Cys Val Gly Phe Thr Lys
     130                 135                 140                
 Lys Arg Asn Asn Gln Ile Arg Lys Thr Ser Tyr Ala Gln His Gln Gln
 145                 150                 155                 160
 Val Arg Gln Ile Arg Lys Lys Met Met Glu Ile Met Thr Arg Glu Val
                 165                 170                 175    
 Gln Thr Asn Asp Leu Lys Glu Val Val Asn Lys Leu Ile Pro Asp Ser
             180                 185                 190        
 Val Gly Lys Asp Ile Glu
         195            



      <210> 511
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 511
 Met Ala Asp Glu Ala Leu Phe Leu Leu Leu His Asn Glu Met Val Ser
   1               5                  10                  15    
 Gly Val Tyr Lys Ser Ala Glu Gln Gly Glu Val Glu Asn Gly Arg Cys
              20                  25                  30        
 Ile Thr Lys Leu Glu Asn Met Gly Phe Arg Val Gly Gln Gly Leu Ile
          35                  40                  45            
 Glu Arg Phe Thr Lys Asp Thr Ala Arg Phe Lys Asp Glu Leu Asp Ile
      50                  55                  60                
 Met Lys Phe Ile Cys Lys Asp Phe Trp Thr Thr Val Phe Lys Lys Gln
  65                  70                  75                  80
 Ile Asp Asn Leu Arg Thr Asn His Gln Gly Ile Tyr Val Leu Gln Asp
                  85                  90                  95    
 Asn Lys Phe Arg Leu Leu Thr Gln Met Ser Ala Gly Lys Gln Tyr Leu
             100                 105                 110        
 Glu His Ala Ser Lys Tyr Leu Ala Phe Thr Cys Gly Leu Ile Arg Gly
         115                 120                 125            
 Gly Leu Ser Asn Leu Gly Ile Lys Ser Ile Val Thr Ala Glu Val Ser
     130                 135                 140                
 Ser Met Pro Ala Cys Lys Phe Gln Val Met Ile Gln Lys Leu
 145                 150                 155            



      <210> 512
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 512
 Met Leu Arg Arg Ala Pro Val Ser Asp Ala Gly Thr Gly Phe Pro Pro
   1               5                  10                  15    
 His Ser Thr Ser Pro Asp Gln Val Phe Gly Cys Gln Leu Glu Ser Leu
              20                  25                  30        
 Cys Gln Arg Glu Gly Asp Thr Val Pro Ser Phe Leu Arg Leu Cys Ile
          35                  40                  45            
 Ala Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val
      50                  55                  60                
 Ser Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu Val Asp Arg
  65                  70                  75                  80
 Glu Arg Ala Val Thr Ser Asp Gly Arg Tyr Val Phe Pro Glu Gln Pro
                  85                  90                  95    
 Gly Gln Glu Gly Arg Leu Asp Leu Asp Ser Thr Glu Trp Asp Asp Ile
             100                 105                 110        
 His Val Val Thr Gly Ala Leu Lys Leu Phe Leu Arg Glu Leu Pro Gln
         115                 120                 125            
 Pro Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala Ala Leu Ala
     130                 135                 140                
 Leu Ser Glu Ser Glu Gln Cys Leu Ser Gln Ile Gln Glu Leu Ile Gly
 145                 150                 155                 160
 Ser Met Pro Lys Pro Asn His Asp Thr Leu Arg Tyr Leu Leu Glu His
                 165                 170                 175    
 Leu Cys Arg Val Ile Ala His Ser Asp Lys Asn Arg Met Thr Pro His
             180                 185                 190        
 Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Phe Arg Pro Glu Gln Glu
         195                 200                 205            
 Thr Ser Asp Pro Ala Ala His Ala Leu Tyr Pro Gly Gln Leu Val Gln
     210                 215                 220                
 Leu Met Leu Thr Asn Phe Thr Ser Leu Phe Pro
 225                 230                 235



      <210> 513
      <211> 900
      <212> PRT
      <213> Homo sapiens


      <400> 513
 Met Pro Gly Met Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro
   1               5                  10                  15    
 Ser Gly Gln Pro Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro
              20                  25                  30        
 Gly Ala Pro Gly Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly
          35                  40                  45            
 Arg Glu Gly Leu Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala
      50                  55                  60                
 Pro Gly Pro Val Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala
  65                  70                  75                  80
 Gly Phe Thr Gly Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly
                  85                  90                  95    
 Ile Asp Gly Met Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser
             100                 105                 110        
 Pro Gly Met Asp Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro
         115                 120                 125            
 Gly Phe Pro Gly Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly
     130                 135                 140                
 Leu Lys Gly Leu Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp
 145                 150                 155                 160
 Pro Gly Pro Pro Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp
                 165                 170                 175    
 Ile Lys Gly Glu Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr
             180                 185                 190        
 Leu Gly Ala Lys Gly Ile Gln Gly Met Pro Gly Ile Pro Gly Leu Ser
         195                 200                 205            
 Gly Ile Pro Gly Leu Pro Gly Arg Pro Gly His Ile Lys Gly Val Lys
     210                 215                 220                
 Gly Asp Ile Gly Val Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly
 225                 230                 235                 240
 Val Ala Gly Pro Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser
                 245                 250                 255    
 Arg Gly Asp Lys Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu Ile
             260                 265                 270        
 Gly Ala Thr Gly Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn Leu Pro
         275                 280                 285            
 Gly Arg Pro Gly Leu Lys Gly Glu Arg Gly Thr Thr Gly Ile Pro Gly
     290                 295                 300                
 Leu Lys Gly Phe Phe Gly Glu Lys Gly Thr Glu Gly Asp Ile Gly Phe
 305                 310                 315                 320
 Pro Gly Ile Thr Gly Val Thr Gly Val Gln Gly Pro Pro Gly Leu Lys
                 325                 330                 335    
 Gly Gln Thr Gly Phe Pro Gly Leu Thr Gly Pro Pro Gly Ser Gln Gly
             340                 345                 350        
 Glu Leu Gly Arg Ile Gly Leu Pro Gly Gly Lys Gly Asp Asp Gly Trp
         355                 360                 365            
 Pro Gly Ala Pro Gly Leu Pro Gly Phe Pro Gly Leu Arg Gly Ile Arg
     370                 375                 380                
 Gly Leu His Gly Leu Pro Gly Thr Lys Gly Phe Pro Gly Ser Pro Gly
 385                 390                 395                 400
 Ser Asp Ile His Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg
                 405                 410                 415    
 Gly Asp Pro Gly Glu Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro
             420                 425                 430        
 Gly Gln Lys Gly Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly
         435                 440                 445            
 Ser Pro Gly Leu Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile
     450                 455                 460                
 Ser Gly Ala Pro Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys
 465                 470                 475                 480
 Gly Tyr Arg Gly Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly
                 485                 490                 495    
 Ser Lys Gly Asp Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly Thr
             500                 505                 510        
 Lys Gly Trp Ala Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly Val Phe
         515                 520                 525            
 Gly Leu Pro Gly Glu Lys Gly Pro Arg Gly Glu Gln Gly Phe Met Gly
     530                 535                 540                
 Asn Thr Gly Pro Thr Gly Ala Val Gly Asp Arg Gly Pro Lys Gly Pro
 545                 550                 555                 560
 Lys Gly Asp Pro Gly Phe Pro Gly Ala Pro Gly Thr Val Gly Ala Pro
                 565                 570                 575    
 Gly Ile Ala Gly Ile Pro Gln Lys Ile Ala Val Gln Pro Gly Thr Val
             580                 585                 590        
 Gly Pro Gln Gly Arg Arg Gly Pro Pro Gly Ala Pro Gly Glu Met Gly
         595                 600                 605            
 Pro Gln Gly Pro Pro Gly Glu Pro Gly Phe Arg Gly Ala Pro Gly Lys
     610                 615                 620                
 Ala Gly Pro Gln Gly Arg Gly Gly Val Ser Ala Val Pro Gly Phe Arg
 625                 630                 635                 640
 Gly Asp Glu Gly Pro Ile Gly His Gln Gly Pro Ile Gly Gln Glu Gly
                 645                 650                 655    
 Ala Pro Gly Arg Pro Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg
             660                 665                 670        
 Ser Val Ser Ile Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln
         675                 680                 685            
 Glu Pro Met Cys Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser
     690                 695                 700                
 Leu Leu Tyr Phe Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly
 705                 710                 715                 720
 Leu Ala Gly Ser Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr
                 725                 730                 735    
 Cys Asn Pro Gly Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser
             740                 745                 750        
 Tyr Trp Leu Ser Thr Thr Ala Pro Leu Pro Met Met Pro Val Ala Glu
         755                 760                 765            
 Asp Glu Ile Lys Pro Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro
     770                 775                 780                
 Ala Ile Ala Ile Ala Val His Ser Gln Asp Val Ser Ile Pro His Cys
 785                 790                 795                 800
 Pro Ala Gly Trp Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His
                 805                 810                 815    
 Thr Ala Ala Gly Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly
             820                 825                 830        
 Ser Cys Leu Glu Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly
         835                 840                 845            
 Gly Arg Gly Thr Cys His Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu
     850                 855                 860                
 Thr Thr Ile Pro Glu Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr
 865                 870                 875                 880
 Leu Lys Ala Gly Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys
                 885                 890                 895    
 Met Lys Asn Leu
             900



      <210> 514
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 514
 Met Ala Val Asp Gln Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro
   1               5                  10                  15    
 Phe Lys Pro Ser Ala Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val
              20                  25                  30        
 Lys Lys Gly Val Pro Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys
          35                  40                  45            
 Ile Pro Asn Phe Leu His Leu Thr Pro Val Ala Ile Lys Lys His Cys
      50                  55                  60                
 Glu Ala Leu Lys Asp Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser
  65                  70                  75                  80
 Asp Glu Lys Cys Glu Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp
                  85                  90                  95    
 Tyr Val Ser Ser Gly Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val
             100                 105                 110        
 Val Leu Arg Val Lys Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys
         115                 120                 125            
 Lys Lys Leu Ile Lys Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp
     130                 135                 140                
 Val Leu Thr Ile Lys Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr
 145                 150                 155                 160
 Asp Tyr Ala Val Tyr Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn
                 165                 170                 175    
 Thr Glu Glu Trp Glu Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr
             180                 185                 190        
 Ile Trp Glu Asn Ser Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu
         195                 200                 205            
 Gln Met Lys Ala Ala Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu
     210                 215                 220                
 Leu Gly Thr Lys Glu Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu
 225                 230                 235                 240
 Lys Asn Glu Glu Glu Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser
                 245                 250                 255    
 Val Lys Arg Leu Leu Asn Val Thr
             260                



      <210> 515
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 515
 Met Ser Ala Ser Leu Val Arg Ala Thr Val Arg Ala Val Ser Lys Arg
   1               5                  10                  15    
 Lys Leu Gln Pro Thr Arg Ala Ala Leu Thr Leu Thr Pro Ser Ala Val
              20                  25                  30        
 Asn Lys Ile Lys Gln Leu Leu Lys Asp Lys Pro Glu His Val Gly Val
          35                  40                  45            
 Lys Val Gly Val Arg Thr Arg Gly Cys Asn Gly Leu Ser Tyr Thr Leu
      50                  55                  60                
 Glu Tyr Thr Lys Thr Lys Gly Asp Ser Asp Glu Glu Val Ile Gln Asp
  65                  70                  75                  80
 Gly Val Arg Val Phe Ile Glu Lys Lys Ala Gln Leu Thr Leu Leu Gly
                  85                  90                  95    
 Thr Glu Met Asp Tyr Val Glu Asp Lys Leu Ser Ser Glu Phe Val Phe
             100                 105                 110        
 Asn Asn Pro Asn Ile Lys Gly Thr Cys Gly Cys Gly Glu Ser Phe Asn
         115                 120                 125            
 Ile
    



      <210> 516
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 516
 Met Ala Ser Ala Gly Val Ala Ala Gly Arg Gln Ala Glu Asp Val Leu
   1               5                  10                  15    
 Pro Pro Thr Ser Asp Gln Pro Leu Pro Asp Thr Lys Pro Leu Pro Pro
              20                  25                  30        
 Pro Gln Pro Pro Pro Val Pro Ala Pro Gln Pro Gln Gln Ser Pro Ala
          35                  40                  45            
 Pro Arg Pro Gln Ser Pro Ala Arg Ala Arg Glu Glu Glu Asn Tyr Ser
      50                  55                  60                
 Phe Leu Pro Leu Val His Asn Ile Ile Lys Cys Met Asp Lys Asp Ser
  65                  70                  75                  80
 Pro Glu Val His Gln Asp Leu Asn Ala Leu Lys Ser Lys Phe Gln Glu
                  85                  90                  95    
 Met Arg Lys Leu Ile Ser Thr Met Pro Gly Ile His Leu Ser Pro Glu
             100                 105                 110        
 Gln Gln Gln Gln Gln Leu Gln Ser Leu Arg Glu Gln Val Arg Thr Lys
         115                 120                 125            
 Asn Glu Leu Leu Gln Lys Tyr Lys Ser Leu Cys Met Phe Glu Ile Pro
     130                 135                 140                
 Lys Glu
 145    



      <210> 517
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 517
 Met Met His Pro Lys Gln Asn Ile Lys Arg Thr Lys Arg Lys Lys Glu
   1               5                  10                  15    
 Tyr Leu Asn Glu Asp Val Asn Gly Phe Met Glu Tyr Leu Arg Gln Asn
              20                  25                  30        
 Ser Gln Met Val His Asn Gly Gln Ile Ile Ala Thr Asp Ser Glu Glu
          35                  40                  45            
 Val Arg Glu Glu Ile Ala Val Ala Leu Lys Lys Asp Ser Arg Arg Glu
      50                  55                  60                
 Gly Arg Arg Leu Lys Arg Gln Ala Ala Lys Lys Asn Ala Met Val Cys
  65                  70                  75                  80
 Phe His Cys Arg Lys Pro Gly His Gly Ile Ala Asp Cys Pro Ala Ala
                  85                  90                  95    
 Leu Glu Asn Gln Asp Met Gly Thr Gly Ile Cys Tyr Arg Cys Gly Ser
             100                 105                 110        
 Thr Glu His Glu Ile Thr Lys Cys Lys Ala Lys Val Asp Pro Ala Leu
         115                 120                 125            
 Gly Glu Phe Pro Phe Ala Lys Cys Phe Val Cys Gly Glu Met Gly His
     130                 135                 140                
 Leu Ser Arg Ser Cys Pro Asp Asn Pro Lys Gly Leu Tyr Ala Asp Gly
 145                 150                 155                 160
 Gly Gly Cys Lys Leu Cys Gly Ser Val Glu His Leu Lys Lys Asp Cys
                 165                 170                 175    
 Pro Glu Ser Gln Asn Ser Glu Arg Met Val Thr Val Gly Arg Trp Ala
             180                 185                 190        
 Lys Gly Met Ser Ala Asp Tyr Glu Glu Ile Leu Asp Val Pro Lys Pro
         195                 200                 205            
 Gln Lys Pro Lys Thr Lys Ile Pro Lys Val Val Asn Phe
     210                 215                 220    



      <210> 518
      <211> 535
      <212> PRT
      <213> Homo sapiens


      <400> 518
 Met Glu Glu Gly Ala Arg His Arg Asn Asn Thr Glu Lys Lys His Pro
   1               5                  10                  15    
 Gly Gly Gly Glu Ser Asp Ala Ser Pro Glu Ala Gly Ser Gly Gly Gly
              20                  25                  30        
 Gly Val Ala Leu Lys Lys Glu Ile Gly Leu Val Ser Ala Cys Gly Ile
          35                  40                  45            
 Ile Val Gly Asn Ile Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly
      50                  55                  60                
 Val Leu Glu Asn Ala Gly Ser Val Gly Leu Ala Leu Ile Val Trp Ile
  65                  70                  75                  80
 Val Thr Gly Phe Ile Thr Val Val Gly Ala Leu Cys Tyr Ala Glu Leu
                  85                  90                  95    
 Gly Val Thr Ile Pro Lys Ser Gly Gly Asp Tyr Ser Tyr Val Lys Asp
             100                 105                 110        
 Ile Phe Gly Gly Leu Ala Gly Phe Leu Arg Leu Trp Ile Ala Val Leu
         115                 120                 125            
 Val Ile Tyr Pro Thr Asn Gln Ala Val Ile Ala Leu Thr Phe Ser Asn
     130                 135                 140                
 Tyr Val Leu Gln Pro Leu Phe Pro Thr Cys Phe Pro Pro Glu Ser Gly
 145                 150                 155                 160
 Leu Arg Leu Leu Ala Ala Ile Cys Leu Leu Leu Leu Thr Trp Val Asn
                 165                 170                 175    
 Cys Ser Ser Val Arg Trp Ala Thr Arg Val Gln Asp Ile Phe Thr Ala
             180                 185                 190        
 Gly Lys Leu Leu Ala Leu Ala Leu Ile Ile Ile Met Gly Ile Val Gln
         195                 200                 205            
 Ile Cys Lys Gly Glu Tyr Phe Trp Leu Glu Pro Lys Asn Ala Phe Glu
     210                 215                 220                
 Asn Phe Gln Glu Pro Asp Ile Gly Leu Val Ala Leu Ala Phe Leu Gln
 225                 230                 235                 240
 Gly Ser Phe Ala Tyr Gly Gly Trp Asn Phe Leu Asn Tyr Val Thr Glu
                 245                 250                 255    
 Glu Leu Val Asp Pro Tyr Lys Asn Leu Pro Arg Ala Ile Phe Ile Ser
             260                 265                 270        
 Ile Pro Leu Val Thr Phe Val Tyr Val Phe Ala Asn Val Ala Tyr Val
         275                 280                 285            
 Thr Ala Met Ser Pro Gln Glu Leu Leu Ala Ser Asn Ala Val Ala Val
     290                 295                 300                
 Thr Phe Gly Glu Lys Leu Leu Gly Val Met Ala Trp Ile Met Pro Ile
 305                 310                 315                 320
 Ser Val Ala Leu Ser Thr Phe Gly Gly Val Asn Gly Ser Leu Phe Thr
                 325                 330                 335    
 Ser Ser Arg Leu Phe Phe Ala Gly Ala Arg Glu Gly His Leu Pro Ser
             340                 345                 350        
 Val Leu Ala Met Ile His Val Lys Arg Cys Thr Pro Ile Pro Ala Leu
         355                 360                 365            
 Leu Phe Thr Cys Ile Ser Thr Leu Leu Met Leu Val Thr Ser Asp Met
     370                 375                 380                
 Tyr Thr Leu Ile Asn Tyr Val Gly Phe Ile Asn Tyr Leu Phe Tyr Gly
 385                 390                 395                 400
 Val Thr Val Ala Gly Gln Ile Val Leu Arg Trp Lys Lys Pro Asp Ile
                 405                 410                 415    
 Pro Arg Pro Ile Lys Ile Asn Leu Leu Phe Pro Ile Ile Tyr Leu Leu
             420                 425                 430        
 Phe Trp Ala Phe Leu Leu Val Phe Ser Leu Trp Ser Glu Pro Val Val
         435                 440                 445            
 Cys Gly Ile Gly Leu Ala Ile Met Leu Thr Gly Val Pro Val Tyr Phe
     450                 455                 460                
 Leu Gly Val Tyr Trp Gln His Lys Pro Lys Cys Phe Ser Asp Phe Ile
 465                 470                 475                 480
 Glu Leu Leu Thr Leu Val Ser Gln Lys Met Cys Val Val Val Tyr Pro
                 485                 490                 495    
 Glu Val Glu Arg Gly Ser Gly Thr Glu Glu Ala Asn Glu Asp Met Glu
             500                 505                 510        
 Glu Gln Gln Gln Pro Met Tyr Gln Pro Thr Pro Thr Lys Asp Lys Asp
         515                 520                 525            
 Val Ala Gly Gln Pro Gln Pro
     530                 535



      <210> 519
      <211> 835
      <212> PRT
      <213> Homo sapiens


      <400> 519
 Met Val Ala Met Asp Leu Gly Ser Pro Ser Leu Pro Lys Lys Ser Leu
   1               5                  10                  15    
 Pro Val Pro Gly Ala Leu Glu Gln Val Ala Ser Arg Leu Ser Ser Lys
              20                  25                  30        
 Val Ala Ala Glu Val Pro His Gly Ser Lys Gln Glu Leu Gln Asp Leu
          35                  40                  45            
 Lys Ala Gln Ser Leu Thr Thr Cys Glu Val Cys Gly Ala Cys Phe Glu
      50                  55                  60                
 Thr Arg Lys Gly Leu Ser Ser His Ala Arg Ser His Leu Arg Gln Leu
  65                  70                  75                  80
 Gly Val Ala Glu Ser Glu Ser Ser Gly Ala Pro Ile Asp Leu Leu Tyr
                  85                  90                  95    
 Glu Leu Val Lys Gln Lys Gly Leu Pro Asp Ala His Leu Gly Leu Pro
             100                 105                 110        
 Pro Gly Leu Ala Lys Lys Ser Ser Ser Leu Lys Glu Val Val Ala Gly
         115                 120                 125            
 Ala Pro Arg Pro Gly Leu Leu Ser Leu Ala Lys Pro Leu Asp Ala Pro
     130                 135                 140                
 Ala Val Asn Lys Ala Ile Lys Ser Pro Pro Gly Phe Ser Ala Lys Gly
 145                 150                 155                 160
 Leu Gly His Pro Pro Ser Ser Pro Leu Leu Lys Lys Thr Pro Leu Ala
                 165                 170                 175    
 Leu Ala Gly Ser Pro Thr Pro Lys Asn Pro Glu Asp Lys Ser Pro Gln
             180                 185                 190        
 Leu Ser Leu Ser Pro Arg Pro Ala Ser Pro Lys Ala Gln Trp Pro Gln
         195                 200                 205            
 Ser Glu Asp Glu Gly Pro Leu Asn Leu Thr Ser Gly Pro Glu Pro Ala
     210                 215                 220                
 Arg Asp Ile Arg Cys Glu Phe Cys Gly Glu Phe Phe Glu Asn Arg Lys
 225                 230                 235                 240
 Gly Leu Ser Ser His Ala Arg Ser His Leu Arg Gln Met Gly Val Thr
                 245                 250                 255    
 Glu Trp Tyr Val Asn Gly Ser Pro Ile Asp Thr Leu Arg Glu Ile Leu
             260                 265                 270        
 Lys Arg Arg Thr Gln Ser Arg Pro Gly Gly Pro Pro Asn Pro Pro Gly
         275                 280                 285            
 Pro Ser Pro Lys Ala Leu Ala Lys Met Met Gly Gly Ala Gly Pro Gly
     290                 295                 300                
 Ser Ser Leu Glu Ala Arg Ser Pro Ser Asp Leu His Ile Ser Pro Leu
 305                 310                 315                 320
 Ala Lys Lys Leu Pro Pro Pro Pro Gly Ser Pro Leu Gly His Ser Pro
                 325                 330                 335    
 Thr Ala Ser Pro Pro Pro Thr Ala Arg Lys Met Phe Pro Gly Leu Ala
             340                 345                 350        
 Ala Pro Ser Leu Pro Lys Lys Leu Lys Pro Glu Gln Ile Arg Val Glu
         355                 360                 365            
 Ile Lys Arg Glu Met Leu Pro Gly Ala Leu His Gly Glu Leu His Pro
     370                 375                 380                
 Ser Glu Gly Pro Trp Gly Ala Pro Arg Glu Asp Met Thr Pro Leu Asn
 385                 390                 395                 400
 Leu Ser Ser Arg Ala Glu Pro Val Arg Asp Ile Arg Cys Glu Phe Cys
                 405                 410                 415    
 Gly Glu Phe Phe Glu Asn Arg Lys Gly Leu Ser Ser His Ala Arg Ser
             420                 425                 430        
 His Leu Arg Gln Met Gly Val Thr Glu Trp Ser Val Asn Gly Ser Pro
         435                 440                 445            
 Ile Asp Thr Leu Arg Glu Ile Leu Lys Lys Lys Ser Lys Pro Cys Leu
     450                 455                 460                
 Ile Lys Lys Glu Pro Pro Ala Gly Asp Leu Ala Pro Ala Leu Ala Glu
 465                 470                 475                 480
 Asp Gly Pro Pro Thr Val Ala Pro Gly Pro Val Gln Ser Pro Leu Pro
                 485                 490                 495    
 Leu Ser Pro Leu Ala Gly Arg Pro Gly Lys Pro Gly Ala Gly Pro Ala
             500                 505                 510        
 Gln Val Pro Arg Glu Leu Ser Leu Thr Pro Ile Thr Gly Ala Lys Pro
         515                 520                 525            
 Ser Ala Thr Gly Tyr Leu Gly Ser Val Ala Ala Lys Arg Pro Leu Gln
     530                 535                 540                
 Glu Asp Arg Leu Leu Pro Ala Glu Val Lys Ala Lys Thr Tyr Ile Gln
 545                 550                 555                 560
 Thr Glu Leu Pro Phe Lys Ala Lys Thr Leu His Glu Lys Thr Ser His
                 565                 570                 575    
 Ser Ser Thr Glu Ala Cys Cys Glu Leu Cys Gly Leu Tyr Phe Glu Asn
             580                 585                 590        
 Arg Lys Ala Leu Ala Ser His Ala Arg Ala His Leu Arg Gln Phe Gly
         595                 600                 605            
 Val Thr Glu Trp Cys Val Asn Gly Ser Pro Ile Glu Thr Leu Ser Glu
     610                 615                 620                
 Trp Ile Lys His Arg Pro Gln Lys Val Gly Ala Tyr Arg Ser Tyr Ile
 625                 630                 635                 640
 Gln Gly Gly Arg Pro Phe Thr Lys Lys Phe Arg Ser Ala Gly His Gly
                 645                 650                 655    
 Arg Asp Ser Asp Lys Arg Pro Ser Leu Gly Leu Ala Pro Gly Gly Leu
             660                 665                 670        
 Ala Val Val Gly Arg Ser Ala Gly Gly Glu Pro Gly Pro Glu Ala Gly
         675                 680                 685            
 Arg Ala Ala Asp Gly Gly Glu Arg Pro Leu Ala Ala Ser Pro Pro Gly
     690                 695                 700                
 Thr Val Lys Ala Glu Glu His Gln Arg Gln Asn Ile Asn Lys Phe Glu
 705                 710                 715                 720
 Arg Arg Gln Ala Arg Pro Pro Asp Ala Ser Ala Ala Arg Gly Gly Glu
                 725                 730                 735    
 Asp Thr Asn Asp Leu Gln Gln Lys Leu Glu Glu Val Arg Gln Pro Pro
             740                 745                 750        
 Pro Arg Val Arg Pro Val Pro Ser Leu Val Pro Arg Pro Pro Gln Thr
         755                 760                 765            
 Ser Leu Val Lys Phe Val Gly Asn Ile Tyr Thr Leu Lys Cys Arg Phe
     770                 775                 780                
 Cys Glu Val Glu Phe Gln Gly Pro Leu Ser Ile Gln Glu Glu Trp Val
 785                 790                 795                 800
 Arg His Leu Gln Arg His Ile Leu Glu Met Asn Phe Ser Lys Ala Asp
                 805                 810                 815    
 Pro Pro Pro Glu Glu Ser Gln Ala Pro Gln Ala Gln Thr Ala Ala Ala
             820                 825                 830        
 Glu Ala Pro
         835



      <210> 520
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 520
 Met Pro Asn Ala Pro Ser Leu Gly His Trp Phe Lys Ser Leu Gly Lys
   1               5                  10                  15    
 Arg Asp Ser Trp Leu Val Ser Ser Gly Pro Leu His Pro Leu Pro Ser
              20                  25                  30        
 Trp Ser Trp Gly Ser Val Ser Gly Cys Phe Val Cys Trp Trp Asp Pro
          35                  40                  45            
 Gly Asn Arg Ala Pro Ser Ala Leu Val Arg Cys Arg Trp Ala Ala Gly
      50                  55                  60                
 Pro Leu Ala Ala Ala Gln His Gly Glu Glu Val Val Leu Glu Asp Lys
  65                  70                  75                  80
 Glu Val Asp Gly
                



      <210> 521
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 521
 Met Ser Lys Thr Gln Cys Tyr His Thr Ser Pro Cys Ser Phe Lys Lys
   1               5                  10                  15    
 Gln Gln Lys Gln Ala Leu Leu Ala Arg Pro Ser Ser Thr Ile Thr Tyr
              20                  25                  30        
 Leu Thr Asp Ser Pro Lys Pro Ala Leu Cys Val Thr Leu Ala Gly Leu
          35                  40                  45            
 Ile Pro Phe Val Ala Pro Pro Leu Val Met Leu Met Thr Lys Thr Tyr
      50                  55                  60                
 Ile Pro Ile Leu Ala Phe Thr Gln Met Ala Tyr Gly Ala Ser Phe Leu
  65                  70                  75                  80
 Ser Phe Leu Gly Gly Ile Arg Trp Gly Phe Ala Leu Pro Glu Gly Ser
                  85                  90                  95    
 Pro Ala Lys Pro Asp Tyr Leu Asn Leu Ala Ser Ser Ala Ala Pro Leu
             100                 105                 110        
 Phe Phe Ser Trp Phe Ala Phe Leu Ile Ser Glu Arg Leu Ser Glu Ala
         115                 120                 125            
 Ile Val Thr Val Ile Met Gly Met Gly Val Ala Phe His Leu Glu Leu
     130                 135                 140                
 Phe Leu Leu Pro His Tyr Pro Asn Trp Phe Lys Ala Leu Arg Ile Val
 145                 150                 155                 160
 Val Thr Leu Leu Ala Thr Phe Ser Phe Ile Ile Thr Leu Val Val Lys
                 165                 170                 175    
 Ser Ser Phe Pro Glu Lys Gly His Lys Arg Pro Gly Gln Val
             180                 185                 190



      <210> 522
      <211> 298
      <212> PRT
      <213> Homo sapiens


      <400> 522
 Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr
   1               5                  10                  15    
 Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly
              20                  25                  30        
 Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp
          35                  40                  45            
 Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu
      50                  55                  60                
 Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr Ser Phe
  65                  70                  75                  80
 Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu Ile Glu
                  85                  90                  95    
 Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met Arg Arg
             100                 105                 110        
 Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala Pro Thr
         115                 120                 125            
 Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu Thr Gln
     130                 135                 140                
 Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly Glu Thr
 145                 150                 155                 160
 Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg Glu Arg
                 165                 170                 175    
 Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu Lys Gln
             180                 185                 190        
 Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn Asn Asn
         195                 200                 205            
 Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu Asp Lys
     210                 215                 220                
 Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala Leu Ile
 225                 230                 235                 240
 Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala Pro Leu
                 245                 250                 255    
 Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln Leu Leu
             260                 265                 270        
 Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn Glu Val
         275                 280                 285            
 Leu Trp Ala Val Val Ala Ala Phe Thr Lys
     290                 295            



      <210> 523
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 523
 Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu
   1               5                  10                  15    
 Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu
              20                  25                  30        
 Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln
          35                  40                  45            
 Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys
      50                  55                  60                
 Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe
  65                  70                  75                  80
 Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys
                  85                  90                  95    
 Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp
             100                 105                 110        
 Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val
         115                 120                 125            
 Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu
     130                 135                 140                
 Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg
 145                 150                 155                 160
 Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser
                 165                 170                 175    
 His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe
             180                 185                 190        
 Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys
         195                 200                 205            
 Arg Ser Val Glu Gly Ser Cys Gly Ser Arg Cys Pro Leu Gly Ile Leu
     210                 215                 220                





      <210> 524
      <211> 672
      <212> PRT
      <213> Homo sapiens


      <400> 524
 Met Lys Arg Val Phe Asp Thr Tyr Met Leu Phe Phe Gln Val Asn Gln
   1               5                  10                  15    
 Ser Ala Thr Ala Leu Lys His Val Phe Ala Ser Leu Arg Leu Phe Val
              20                  25                  30        
 Cys Lys Phe Pro Ser Ala Phe Phe Gln Gly Pro Ala Asp Leu Cys Gly
          35                  40                  45            
 Ser Phe Cys Tyr Glu Val Leu Lys Cys Cys Asn His Arg Ser Arg Ser
      50                  55                  60                
 Thr Gln Thr Glu Ala Ser Ala Leu Leu Tyr Leu Phe Met Arg Lys Asn
  65                  70                  75                  80
 Phe Glu Phe Asn Lys Gln Lys Ser Ile Val Arg Ser His Leu Gln Leu
                  85                  90                  95    
 Ile Lys Ala Val Ser Gln Leu Ile Ala Asp Ala Gly Ile Gly Gly Ser
             100                 105                 110        
 Arg Phe Gln His Ser Leu Ala Ile Thr Asn Asn Phe Ala Asn Gly Asp
         115                 120                 125            
 Lys Gln Met Lys Asn Ser Asn Phe Pro Ala Glu Val Lys Asp Leu Thr
     130                 135                 140                
 Lys Arg Ile Arg Thr Val Leu Met Ala Thr Ala Gln Met Lys Glu His
 145                 150                 155                 160
 Glu Lys Asp Pro Glu Met Leu Val Asp Leu Gln Tyr Ser Leu Ala Asn
                 165                 170                 175    
 Ser Tyr Ala Ser Thr Pro Glu Leu Arg Arg Thr Trp Leu Glu Ser Met
             180                 185                 190        
 Ala Lys Ile His Ala Arg Asn Gly Asp Leu Ser Glu Ala Ala Met Cys
         195                 200                 205            
 Tyr Ile His Ile Ala Ala Leu Ile Ala Glu Tyr Leu Lys Arg Lys Gly
     210                 215                 220                
 Tyr Trp Lys Val Glu Lys Ile Cys Thr Ala Ser Leu Leu Ser Glu Asp
 225                 230                 235                 240
 Thr His Pro Cys Asp Ser Asn Ser Leu Leu Thr Thr Pro Ser Gly Gly
                 245                 250                 255    
 Ser Met Phe Ser Met Gly Trp Pro Ala Phe Leu Ser Ile Thr Pro Asn
             260                 265                 270        
 Ile Lys Glu Glu Gly Ala Met Lys Glu Asp Ser Gly Met Gln Asp Thr
         275                 280                 285            
 Pro Tyr Asn Glu Asn Ile Leu Val Glu Gln Leu Tyr Met Cys Val Glu
     290                 295                 300                
 Phe Leu Trp Lys Ser Glu Arg Tyr Glu Leu Ile Ala Asp Val Asn Lys
 305                 310                 315                 320
 Pro Ile Ile Ala Val Phe Glu Lys Gln Arg Asp Phe Lys Lys Leu Ser
                 325                 330                 335    
 Asp Leu Tyr Tyr Asp Ile His Arg Ser Tyr Leu Lys Val Ala Glu Val
             340                 345                 350        
 Val Asn Ser Glu Lys Arg Leu Phe Gly Arg Tyr Tyr Arg Val Ala Phe
         355                 360                 365            
 Tyr Gly Gln Gly Phe Phe Glu Glu Glu Glu Gly Lys Glu Tyr Ile Tyr
     370                 375                 380                
 Lys Glu Pro Lys Leu Thr Gly Leu Ser Glu Ile Ser Gln Arg Leu Leu
 385                 390                 395                 400
 Lys Leu Tyr Ala Asp Lys Phe Gly Ala Asp Asn Val Lys Ile Ile Gln
                 405                 410                 415    
 Asp Ser Asn Lys Val Asn Pro Lys Asp Leu Asp Pro Lys Tyr Ala Tyr
             420                 425                 430        
 Ile Gln Val Thr Tyr Val Thr Pro Phe Phe Glu Glu Lys Glu Ile Glu
         435                 440                 445            
 Asp Arg Lys Thr Asp Phe Glu Met His His Asn Ile Asn Arg Phe Val
     450                 455                 460                
 Phe Glu Thr Pro Phe Thr Leu Ser Gly Lys Lys His Gly Gly Val Ala
 465                 470                 475                 480
 Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr Thr Ser His Leu Phe Pro
                 485                 490                 495    
 Tyr Val Lys Lys Arg Ile Gln Val Ile Ser Gln Ser Ser Thr Glu Leu
             500                 505                 510        
 Asn Pro Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val Ser Glu
         515                 520                 525            
 Leu Asn Gln Leu Cys Thr Met Glu Glu Val Asp Met Ile Arg Leu Gln
     530                 535                 540                
 Leu Lys Leu Gln Gly Ser Val Ser Val Lys Val Asn Ala Gly Pro Met
 545                 550                 555                 560
 Ala Tyr Ala Arg Ala Phe Leu Glu Glu Thr Asn Ala Lys Lys Tyr Pro
                 565                 570                 575    
 Asp Asn Gln Val Lys Leu Leu Lys Glu Ile Phe Arg Gln Phe Ala Asp
             580                 585                 590        
 Ala Cys Gly Gln Ala Leu Asp Val Asn Glu Arg Leu Ile Lys Glu Asp
         595                 600                 605            
 Gln Leu Glu Tyr Gln Glu Glu Leu Arg Ser His Tyr Lys Asp Met Leu
     610                 615                 620                
 Ser Glu Leu Ser Thr Val Met Asn Glu Gln Ile Thr Gly Arg Asp Asp
 625                 630                 635                 640
 Leu Ser Lys Arg Gly Val Asp Gln Thr Cys Thr Arg Val Ile Ser Lys
                 645                 650                 655    
 Ala Thr Pro Ala Leu Pro Thr Val Ser Ile Ser Ser Ser Ala Glu Val
             660                 665                 670        





      <210> 525
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 525
 Met Leu Gln Gly Ser Gln Ala Ala Leu Tyr Ile Gln Lys Ile Pro Glu
   1               5                  10                  15    
 Gln Pro Gln Lys Asn Gln Asp Leu Leu Leu Ser Val Gln Gly Val Pro
              20                  25                  30        
 Asp Thr Phe Gln Asp Phe Asn Trp Tyr Leu Gly Glu Glu Thr Tyr Gly
          35                  40                  45            
 Gly Thr Arg Leu Phe Thr Tyr Ile Pro Gly Ile Gln Arg Pro Gln Arg
      50                  55                  60                
 Asp Gly Ser Ala Met Gly Gln Arg Asp Ile Val Gly Phe Pro Asn Gly
  65                  70                  75                  80
 Ser Met Leu Leu Arg Arg Ala Gln Pro Thr Asp Ser Gly Thr Tyr Gln
                  85                  90                  95    
 Val Ala Ile Thr Ile Asn Ser Glu Trp Thr Met Lys Ala Lys Thr Glu
             100                 105                 110        
 Val Gln Val Ala Asp
         115        



      <210> 526
      <211> 438
      <212> PRT
      <213> Homo sapiens


      <400> 526
 Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
   1               5                  10                  15    
 Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
              20                  25                  30        
 Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
          35                  40                  45            
 Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
      50                  55                  60                
 Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
  65                  70                  75                  80
 Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                  85                  90                  95    
 Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
             100                 105                 110        
 Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
         115                 120                 125            
 Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
     130                 135                 140                
 Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
 145                 150                 155                 160
 Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                 165                 170                 175    
 Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
             180                 185                 190        
 Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
         195                 200                 205            
 Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
     210                 215                 220                
 Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
 225                 230                 235                 240
 Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                 245                 250                 255    
 Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
             260                 265                 270        
 Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
         275                 280                 285            
 Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
     290                 295                 300                
 Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
 305                 310                 315                 320
 Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                 325                 330                 335    
 Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
             340                 345                 350        
 Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
         355                 360                 365            
 Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
     370                 375                 380                
 Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
 385                 390                 395                 400
 Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                 405                 410                 415    
 Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Gln Lys Pro Leu
             420                 425                 430        
 Gly Gln Val Ser Cys Gly
         435            



      <210> 527
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 527
 Met Val Pro Ala Ala Gly Ala Leu Leu Trp Val Leu Leu Leu Asn Leu
   1               5                  10                  15    
 Gly Pro Arg Ala Ala Gly Ala Gln Gly Leu Thr Gln Thr Pro Thr Glu
              20                  25                  30        
 Met Gln Arg Val Ser Leu Arg Phe Gly Gly Pro Met Thr Arg Ser Tyr
          35                  40                  45            
 Arg Ser Thr Ala Arg Thr Gly Leu Pro Arg Lys Thr Arg Ile Ile Leu
      50                  55                  60                
 Glu Asp Glu Asn Asp Ala Met Ala Asp Ala Asp Arg Leu Ala Gly Pro
  65                  70                  75                  80
 Ala Ala Ala Glu Leu Leu Ala Ala Thr Val Ser Thr Gly Phe Ser Arg
                  85                  90                  95    
 Ser Ser Ala Ile Asn Glu Glu Asp Gly Ser Ser Glu Glu Gly Val Val
             100                 105                 110        
 Ile Asn Ala Gly Lys Asp Ser Thr Ser Arg Glu Leu Pro Ser Ala Thr
         115                 120                 125            
 Pro Asn Thr Ala Gly Ser Ser Ser Thr Arg Phe Ile Ala Asn Ser Gln
     130                 135                 140                
 Glu Pro Glu Ile Arg Leu Thr Ser Ser Leu Pro Arg Ser Pro Gly Arg
 145                 150                 155                 160
 Ser Thr Glu Asp Leu Pro Gly Ser Gln Ala Thr Leu Ser Gln Trp Ser
                 165                 170                 175    
 Thr Pro Gly Ser Thr Pro Ser Arg Trp Pro Ser Pro Ser Pro Thr Ala
             180                 185                 190        
 Met Pro Ser Pro Glu Asp Leu Arg Leu Val Leu Met Pro Trp Gly Pro
         195                 200                 205            
 Trp His Cys His Cys Lys Ser Gly Thr Met Ser Arg Ser Arg Ser Gly
     210                 215                 220                
 Lys Leu His Gly Leu Ser Gly Arg Leu Arg Val Gly Ala Leu Ser Gln
 225                 230                 235                 240
 Leu Arg Thr Glu His Lys Pro Cys Thr Tyr Gln Gln Cys Pro Cys Asn
                 245                 250                 255    
 Arg Leu Arg Glu Glu Cys Pro Leu Asp Thr Ser Leu Cys Thr Asp Thr
             260                 265                 270        
 Asn Cys Ala Ser Gln Ser Thr Thr Ser Thr Arg Thr Thr Thr Thr Pro
         275                 280                 285            
 Phe Pro Thr Ile His Leu Arg Ser Ser Pro Ser Leu Pro Pro Ala Ser
     290                 295                 300                
 Pro Cys Pro Ala Leu Ala Phe Trp Lys Arg Val Arg Ile Gly Leu Glu
 305                 310                 315                 320
 Asp Ile Trp Asn Ser Leu Ser Ser Val Phe Thr Glu Met Gln Pro Ile
                 325                 330                 335    
 Asp Arg Asn Gln Arg
             340    



      <210> 528
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 528
 Met Tyr Leu Ile Phe Cys Asn Phe Ser Glu Phe Pro Ala Asp Val His
   1               5                  10                  15    
 Trp Pro His Gly Leu Ala Leu Gly Ile Thr Ser Leu Glu Val Pro Val
              20                  25                  30        
 Pro Ser Asp Lys Gly Pro Trp Ile His Met Thr Ala Cys Leu Phe Phe
          35                  40                  45            
 Leu Glu Thr Gly Pro His Cys Arg Glu Val Ile Val Lys Val Ser Asn
      50                  55                  60                
 Pro Val Met Pro Pro Pro Ala Thr Leu Thr Trp Glu Arg Asp Thr His
  65                  70                  75                  80
 Lys Ser Met Ser Asn Arg His Pro Phe Leu Ser Leu Ser Leu Arg Ser
                  85                  90                  95    
 Gln Gly Val Phe Leu Phe Ser Ser Asp Ser Phe Ser Gln Gly Leu Phe
             100                 105                 110        
 Tyr Lys Asn Pro Cys Pro Glu Gly Tyr Cys
         115                 120        



      <210> 529
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 529
 Met Ala Ser Trp Leu Tyr Glu Cys Leu Cys Glu Ala Glu Leu Ala Gln
   1               5                  10                  15    
 Tyr Tyr Ser His Phe Thr Ala Leu Gly Leu Gln Lys Ile Asp Glu Leu
              20                  25                  30        
 Ala Lys Ile Thr Met Lys Asp Tyr Ser Lys Leu Gly Val His Asp Met
          35                  40                  45            
 Asn Asp Arg Lys Arg Leu Phe Gln Leu Ile Lys Ile Ile Lys Ile Met
      50                  55                  60                
 Gln Glu Glu Asp Lys Ala Val Ser Ile Pro Glu Arg His Leu Gln Thr
  65                  70                  75                  80
 Ser Ser Leu Arg Ile Lys Ser Gln Glu Leu Arg Ser Gly Pro Arg Arg
                  85                  90                  95    
 Gln Leu Asn Phe Asp Ser Pro Ala Asp Asn Lys Asp Arg Asn Ala Ser
             100                 105                 110        
 Asn Asp Gly Phe Glu Met Cys Ser Leu Ser Asp Phe Ser Ala Asn Glu
         115                 120                 125            
 Gln Lys Ser Thr Tyr Leu Lys Val Leu Glu His Met Leu Pro Asp Asp
     130                 135                 140                
 Ser Gln Tyr His Thr Lys Thr Gly Ile Leu Asn Ala Thr Ala Gly Asp
 145                 150                 155                 160
 Ser Tyr Val Gln Thr Glu Ile Ser Thr Ser Leu Phe Ser Pro Asn Tyr
                 165                 170                 175    
 Leu Ser Ala Ile Leu Gly Asp Cys Asp Ile Pro Ile Ile Gln Arg Ile
             180                 185                 190        
 Ser His Val Ser Gly Tyr Asn Tyr Gly Ile Pro His Ser Cys Ile Arg
         195                 200                 205            





      <210> 530
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 530
 Met Leu Ala Asn Cys Gly Ser Val Cys Glu Glu Thr Gln Phe Arg Gly
   1               5                  10                  15    
 Thr Thr Val Ala Pro Ala Leu Gly Glu Phe Phe Thr Thr Thr Thr Lys
              20                  25                  30        
 Glu Gly Tyr Asp Arg Arg Pro Val Asp Ile Thr Pro Leu Glu Gln Arg
          35                  40                  45            
 Lys Leu Thr Phe Asp Thr His Ala Leu Val Gln Asp Leu Glu Thr His
      50                  55                  60                
 Gly Phe Asp Lys Thr Gln Ala Glu Thr Ile Val Ser Ala Leu Thr Ala
  65                  70                  75                  80
 Leu Ser Asn Val Ser Leu Asp Thr Ile Tyr Lys Glu Met Val Thr Gln
                  85                  90                  95    
 Ala Gln Gln Glu Ile Thr Val Gln Gln Leu Met Ala His Leu Asp Ala
             100                 105                 110        
 Ile Arg Lys Asp Met Val Ile Leu Glu Lys Ser Glu Phe Ala Asn Leu
         115                 120                 125            
 Arg Ala Glu Asn Glu Lys Met Lys Ile Glu Leu Asp Gln Val Lys Gln
     130                 135                 140                
 Gln Leu Met His Glu Thr Ser Arg Ile Arg Ala Asp Asn Lys Leu Asp
 145                 150                 155                 160
 Ile Asn Leu Glu Arg Ser Arg Val Thr Asp Met Phe Thr Asp Gln Glu
                 165                 170                 175    
 Lys Gln Leu Met Glu Thr Thr Thr Glu Phe Thr Lys Lys Asp Thr Gln
             180                 185                 190        
 Thr Lys Ser Ile Ile Ser Glu Thr Ser Asn Lys Ile Asp Ala Glu Ile
         195                 200                 205            
 Ala Ser Leu Lys Thr Leu Met Glu Ser Asn Lys Leu Glu Thr Ile Arg
     210                 215                 220                
 Tyr Leu Ala Ala Ser Val Phe Thr Cys Leu Ala Ile Ala Leu Gly Phe
 225                 230                 235                 240
 Tyr Arg Phe Trp Lys
                 245



      <210> 531
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 531
 Met Lys Ser Arg Ile Pro Val Val Leu Leu Ala Cys Gly Ser Phe Asn
   1               5                  10                  15    
 Pro Ile Thr Asn Met His Leu Arg Met Phe Glu Val Ala Arg Asp His
              20                  25                  30        
 Leu His Gln Thr Gly Met Tyr Gln Val Ile Gln Gly Ile Ile Ser Pro
          35                  40                  45            
 Val Asn Asp Thr Tyr Gly Lys Lys Asp Leu Ala Ala Ser His His Arg
      50                  55                  60                
 Val Ala Met Ala Arg Leu Ala Leu Gln Thr Ser Asp Trp Ile Arg Val
  65                  70                  75                  80
 Asp Pro Trp Glu Ser Glu Gln Ala Gln Trp Met Glu Thr Val Lys Val
                  85                  90                  95    
 Leu Arg His His His Ser Lys Leu Leu Arg Ser Pro Pro Gln Met Glu
             100                 105                 110        
 Gly Pro Asp His Gly Lys Ala Leu Phe Ser Thr Pro Ala Ala Val Pro
         115                 120                 125            
 Glu Leu Lys Leu Leu Cys Gly Ala Asp Val Leu Lys Thr Phe Gln Thr
     130                 135                 140                
 Pro Asn Leu Trp Lys Asp Ala His Ile Gln Glu Ile Val Glu Lys Phe
 145                 150                 155                 160
 Gly Leu Val Cys Val Gly Arg Val Gly His Asp Pro Lys Gly Tyr Ile
                 165                 170                 175    
 Ala Glu Ser Pro Ile Leu Arg Met His Gln His Asn Ile His Leu Ala
             180                 185                 190        
 Lys Glu Pro Val Gln Asn Glu Ile Arg Ala Thr Tyr Ile Arg Arg Ala
         195                 200                 205            
 Leu Gly Gln Gly Gln Ser Val Lys Tyr Leu Ile Pro Asp Ala Val Ile
     210                 215                 220                
 Thr Tyr Ile Lys Asp His Gly Leu Tyr Thr Lys Gly Ser Thr Trp Lys
 225                 230                 235                 240
 Gly Lys Ser Thr Gln Ser Thr Glu Gly Lys Thr Ser
                 245                 250        



      <210> 532
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 532
 Met Gln Arg Glu Glu Lys Gln Leu Glu Ala Ser Leu Asp Ala Leu Leu
   1               5                  10                  15    
 Ser Gln Val Ala Asp Leu Lys Asn Ser Leu Gly Ser Phe Ile Cys Lys
              20                  25                  30        
 Leu Glu Asn Glu Tyr Gly Arg Leu Thr Trp Pro Ser Val Leu Asp Ser
          35                  40                  45            
 Phe Ala Leu Leu Ser Gly Gln Leu Asn Thr Leu Asn Lys Val Leu Lys
      50                  55                  60                
 His Glu Lys Thr Pro Leu Phe Arg Asn Gln Val Ile Ile Pro Leu Val
  65                  70                  75                  80
 Leu Ser Pro Asp Arg Asp Glu Asp Leu Met Arg Gln Thr Glu Gly Arg
                  85                  90                  95    
 Val Pro Val Phe Ser His Glu Val Val Pro Asp His Leu Arg Thr Lys
             100                 105                 110        
 Pro Asp Pro Glu Val Glu Glu Gln Glu Lys Gln Leu Thr Thr Asp Ala
         115                 120                 125            
 Ala Arg Ile Gly Ala Asp Ala Ala Gln Lys Gln Ile Gln Ser Leu Asn
     130                 135                 140                
 Lys Met Cys Ser Asn Leu Leu Glu Lys Ile Ser Lys Glu Glu Arg Glu
 145                 150                 155                 160
 Ser Glu Ser Gly Gly Leu Arg Pro Asn Lys Gln Thr Phe Asn Pro Thr
                 165                 170                 175    
 Asp Thr Asn Ala Leu Val Ala Ala Val Ala Phe Gly Lys Gly Leu Ser
             180                 185                 190        
 Asn Trp Arg Pro Ser Gly Ser Ser Gly Pro Gly Gln Ala Gly Gln Pro
         195                 200                 205            
 Gly Ala Gly Thr Ile Leu Ala Gly Thr Ser Gly Leu Gln Gln Val Gln
     210                 215                 220                
 Met Ala Gly Ala Pro Ser Gln Gln Gln Pro Met Leu Ser Gly Val Gln
 225                 230                 235                 240
 Met Ala Gln Ala Gly Gln Pro Gly Lys Met Pro Ser Gly Ile Lys Thr
                 245                 250                 255    
 Asn Ile Lys Ser Ala Ser Met His Pro Tyr Gln Arg
             260                 265            



      <210> 533
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 533
 Met Arg Gln Thr Glu Gly Arg Val Pro Val Phe Ser His Glu Val Val
   1               5                  10                  15    
 Pro Asp His Leu Arg Thr Lys Pro Asp Pro Glu Val Glu Glu Gln Glu
              20                  25                  30        
 Lys Gln Leu Thr Thr Asp Ala Ala Arg Ile Gly Ala Asp Ala Ala Gln
          35                  40                  45            
 Lys Gln Ile Gln Ser Leu Asn Lys Met Cys Ser Asn Leu Leu Glu Lys
      50                  55                  60                
 Ile Ser Lys Glu Glu Arg Glu Ser Glu Ser Gly Gly Leu Arg Pro Asn
  65                  70                  75                  80
 Lys Gln Thr Phe Asn Pro Thr Asp Thr Asn Ala Leu Val Ala Ala Val
                  85                  90                  95    
 Ala Phe Gly Lys Gly Leu Ser Asn Trp Arg Pro Ser Gly Ser Ser Gly
             100                 105                 110        
 Pro Gly Gln Ala Gly Gln Pro Gly Ala Gly Thr Ile Leu Ala Gly Thr
         115                 120                 125            
 Ser Gly Leu Gln Gln Val Gln Met Ala Gly Ala Pro Ser Gln Gln Gln
     130                 135                 140                
 Pro Met Leu Ser Gly Val Gln Met Ala Gln Ala Gly Gln Pro Gly Lys
 145                 150                 155                 160
 Met Pro Ser Gly Ile Lys Thr Asn Ile Lys Ser Ala Ser Met His Pro
                 165                 170                 175    
 Tyr Gln Arg Pro Ser Cys Leu Gly Phe Ile Leu Ala Ile Pro Leu Arg
             180                 185                 190        
 Arg Lys Val Lys Lys Leu Leu Gly Gln Glu Gly Lys Lys Asn Ala His
         195                 200                 205            
 Leu Gln Leu Trp
     210        



      <210> 534
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 534
 Met Ala Ala Arg Thr Gly His Thr Ala Leu Arg Arg Val Val Ser Gly
   1               5                  10                  15    
 Cys Arg Pro Lys Ser Ala Thr Ala Ala Gly Ala Gln Ala Pro Val Arg
              20                  25                  30        
 Asn Gly Arg Tyr Leu Ala Ser Cys Gly Ile Leu Met Ser Arg Thr Leu
          35                  40                  45            
 Pro Leu His Thr Ser Ile Leu Pro Lys Glu Ile Cys Ala Arg Thr Phe
      50                  55                  60                
 Phe Lys Ile Thr Ala Pro Leu Ile Asn Lys Arg Lys Glu Tyr Ser Glu
  65                  70                  75                  80
 Arg Arg Ile Leu Gly Tyr Ser Met Gln Glu Met Tyr Asp Val Val Ser
                  85                  90                  95    
 Gly Val Glu Asp Tyr Lys His Phe Val Pro Trp Cys Lys Lys Ser Asp
             100                 105                 110        
 Val Ile Ser Lys Arg Ser Gly Tyr Cys Lys Thr Arg Leu Glu Ile Gly
         115                 120                 125            
 Phe Pro Pro Val Leu Glu Arg Tyr Thr Ser Val Val Thr Leu Val Lys
     130                 135                 140                
 Pro His Leu Val Lys Ala Ser Cys Thr Asp Gly Arg Leu Phe Asn His
 145                 150                 155                 160
 Leu Glu Thr Ile Trp Arg Phe Ser Pro Gly Leu Pro Gly Tyr Pro Arg
                 165                 170                 175    
 Thr Cys Thr Leu Asp Phe Ser Ile Ser Phe Glu Phe Arg Ser Leu Leu
             180                 185                 190        
 His Ser Gln Leu Ala Thr Leu Phe Phe Asp Glu Val Val Lys Gln Met
         195                 200                 205            
 Val Ala Ala Phe Glu Arg Arg Ala Cys Lys Leu Tyr Gly Pro Glu Thr
     210                 215                 220                
 Asn Ile Pro Arg Glu Leu Met Leu His Glu Val His His Thr
 225                 230                 235            



      <210> 535
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 535
 Met Lys Thr Ile Ser Val Val Gly Ile Glu Leu Cys Pro Pro Gly Lys
   1               5                  10                  15    
 Arg Phe Met Ile Thr Met Val Ala Ser Phe Val Ala Met Ala Gly Gln
              20                  25                  30        
 Phe Leu Met Pro Gly Leu Ala Ala Leu Cys Arg Asp Trp Gln Val Leu
          35                  40                  45            
 Gln Ala Leu Ile Ile Cys Pro Phe Leu Leu Met Leu Leu Tyr Trp Ser
      50                  55                  60                





      <210> 536
      <211> 632
      <212> PRT
      <213> Homo sapiens


      <400> 536
 Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala
   1               5                  10                  15    
 Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys
              20                  25                  30        
 Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly
          35                  40                  45            
 Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe
      50                  55                  60                
 Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp
  65                  70                  75                  80
 Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly
                  85                  90                  95    
 Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His
             100                 105                 110        
 Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys
         115                 120                 125            
 Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly
     130                 135                 140                
 Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser
 145                 150                 155                 160
 Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro
                 165                 170                 175    
 Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly
             180                 185                 190        
 Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro
         195                 200                 205            
 Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly
     210                 215                 220                
 Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro
 225                 230                 235                 240
 Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln
                 245                 250                 255    
 Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro
             260                 265                 270        
 Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys
         275                 280                 285            
 Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly
     290                 295                 300                
 Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr
 305                 310                 315                 320
 Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr
                 325                 330                 335    
 Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly
             340                 345                 350        
 Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly
         355                 360                 365            
 Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu
     370                 375                 380                
 Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly
 385                 390                 395                 400
 Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile
                 405                 410                 415    
 Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly
             420                 425                 430        
 Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp
         435                 440                 445            
 Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp
     450                 455                 460                
 Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr
 465                 470                 475                 480
 Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro
                 485                 490                 495    
 Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly
             500                 505                 510        
 Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu
         515                 520                 525            
 Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys
     530                 535                 540                
 Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys
 545                 550                 555                 560
 Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly
                 565                 570                 575    
 Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu
             580                 585                 590        
 Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro
         595                 600                 605            
 Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly
     610                 615                 620                
 Phe Gly Pro Pro Gly Pro Ser Arg
 625                 630        



      <210> 537
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 537
 Met Gln Pro Ser Gly Trp Ala Ala Ala Arg Glu Ala Ala Gly Arg Asp
   1               5                  10                  15    
 Met Leu Ala Ala Asp Leu Arg Cys Ser Leu Phe Ala Ser Ala Leu Gln
              20                  25                  30        
 Ser Tyr Lys Arg Asp Ser Val Leu Arg Pro Phe Pro Ala Ser Tyr Ala
          35                  40                  45            
 Arg Gly Asp Cys Lys Asp Phe Glu Ala Leu Thr Ser Leu Phe Gly Glu
      50                  55                  60                
 Gly Thr Tyr Leu Thr Ser Asp Leu Ser Leu Ala Leu Ile Tyr Ser Pro
  65                  70                  75                  80
 His Gly His Gly Trp Gln His Ser Leu Leu Gly Pro Ile Leu Ser Cys
                  85                  90                  95    
 Val Ala Val Cys Glu Val Ile Asp His Pro Asp Val Lys Cys Gln Thr
             100                 105                 110        
 Lys Lys Lys Asp Ser Lys Glu Ile Asp Arg Arg Arg Ala Arg Ile Lys
         115                 120                 125            
 His Ser Glu Gly Gly Asp Ile Pro Pro Lys Tyr Phe Val Val Thr Asn
     130                 135                 140                
 Asn Gln Leu Leu Arg Val Lys Tyr Leu Leu Val Tyr Ser Gln Lys Pro
 145                 150                 155                 160
 Pro Lys Arg Ala Ser Ser Gln Leu Ser Trp Phe Ser Ser His Trp Phe
                 165                 170                 175    
 Thr Val Met Ile Ser Leu Tyr Leu Leu Leu Leu Leu Ile Val Ser Val
             180                 185                 190        
 Ile Asn Ser Ser Ala Phe Gln His Phe Trp Asn Arg Ala Lys Arg
         195                 200                 205        



      <210> 538
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 538
 Met Gln Pro Ser Gly Trp Ala Ala Ala Arg Glu Ala Ala Gly Arg Asp
   1               5                  10                  15    
 Met Leu Ala Ala Asp Leu Arg Cys Ser Leu Phe Ala Ser Ala Leu Gln
              20                  25                  30        
 Ser Tyr Lys Arg Asp Ser Val Leu Arg Pro Phe Pro Ala Ser Tyr Ala
          35                  40                  45            
 Arg Gly Asp Cys Lys Asp Phe Glu Ala Leu Phe Glu Lys Ile Gln Lys
      50                  55                  60                
 Leu Thr Gly Ala Pro His Thr Pro Val Pro Ala Pro Asp Phe Leu Phe
  65                  70                  75                  80
 Glu Ile Glu Tyr Phe Asp Pro Ala Asn Ala Lys Phe Tyr Glu Thr Lys
                  85                  90                  95    
 Gly Glu Arg Asp Leu Ile Tyr Ala Phe His Gly Ser Arg Leu Glu Asn
             100                 105                 110        
 Phe His Ser Ile Ile His Asn Gly Leu His Cys His Leu Asn Lys Thr
         115                 120                 125            
 Ser Leu Phe Gly Glu Gly Thr Tyr Leu Thr Ser Asp Leu Ser Leu Ala
     130                 135                 140                
 Leu Ile Tyr Ser Pro His Gly His Gly Trp Gln His Ser Leu Leu Gly
 145                 150                 155                 160
 Pro Ile Leu Ser Cys Val Ala Val Cys Glu Val Ile Asp His Pro Asp
                 165                 170                 175    
 Val Lys Cys Gln Thr Lys Lys Lys Asp Ser Lys Glu Ile Asp Arg Arg
             180                 185                 190        
 Arg Ala Arg Ile Lys His Ser Glu Gly Gly Asp Ile Pro Pro Lys Tyr
         195                 200                 205            
 Phe Val Val Thr Asn Asn Gln Leu Leu Arg Val Lys Tyr Leu Leu Val
     210                 215                 220                
 Tyr Ser Gln Lys Pro Pro Lys Arg Ala Ser Ser Gln Leu Ser Trp Phe
 225                 230                 235                 240
 Ser Ser His Trp Phe Thr Val Met Ile Ser Leu Tyr Leu Leu Leu Leu
                 245                 250                 255    
 Leu Ile Val Ser Val Ile Asn Ser Ser Ala Phe Gln His Phe Trp Asn
             260                 265                 270        
 Arg Ala Lys Arg
         275    



      <210> 539
      <211> 730
      <212> PRT
      <213> Homo sapiens


      <400> 539
 Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Val Leu Gly Lys Ala
   1               5                  10                  15    
 Ser Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly
              20                  25                  30        
 Arg Asn Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys
          35                  40                  45            
 Asn Asp Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val
      50                  55                  60                
 Lys Ala Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala
  65                  70                  75                  80
 Val Gly Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro
                  85                  90                  95    
 Asp Gly Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu
             100                 105                 110        
 Ala Cys Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu
         115                 120                 125            
 Asn Lys Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro
     130                 135                 140                
 Asp Asp Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu
 145                 150                 155                 160
 Thr Ala Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly
                 165                 170                 175    
 Gly Thr Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly
             180                 185                 190        
 Phe Asp Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu
         195                 200                 205            
 Thr Gln Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg
     210                 215                 220                
 Gly Leu Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu
 225                 230                 235                 240
 Leu Cys Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro
                 245                 250                 255    
 Glu Cys Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser
             260                 265                 270        
 Lys Leu Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg
         275                 280                 285            
 Leu Ala His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly
     290                 295                 300                
 Ser Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg
 305                 310                 315                 320
 Leu Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr
                 325                 330                 335    
 Ala Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys
             340                 345                 350        
 Glu Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val
         355                 360                 365            
 Met Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly
     370                 375                 380                
 Ser Glu Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu
 385                 390                 395                 400
 Gly Ala Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys
                 405                 410                 415    
 Gln Leu Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu
             420                 425                 430        
 Ala Glu Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile
         435                 440                 445            
 Ser Pro Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu
     450                 455                 460                
 Leu Leu Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu
 465                 470                 475                 480
 Ile Leu Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu
                 485                 490                 495    
 Gln Gln Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro
             500                 505                 510        
 Asp Ser Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn
         515                 520                 525            
 Leu Val Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr
     530                 535                 540                
 Ser Leu Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln
 545                 550                 555                 560
 Gln Gly Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu
                 565                 570                 575    
 Met Ala Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala
             580                 585                 590        
 Ser Arg Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His
         595                 600                 605            
 Val Ala Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser
     610                 615                 620                
 Pro Glu Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu
 625                 630                 635                 640
 Gly Met Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala
                 645                 650                 655    
 Pro Ala Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu
             660                 665                 670        
 Gly Ser Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr
         675                 680                 685            
 Gln Gly Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu
     690                 695                 700                
 Ala Met Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met
 705                 710                 715                 720
 Ala Ala Leu Glu Gln Cys Leu Ser Glu Pro
                 725                 730



      <210> 540
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 540
 Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Thr Gly Trp Gln
   1               5                  10                  15    
 Pro Arg Trp Phe Val Leu Asp Asn Gly Ile Leu Ser Tyr Tyr Asp Ser
              20                  25                  30        
 Gln Asp Asp Val Cys Lys Gly Ser Lys Gly Ser Ile Lys Met Ala Val
          35                  40                  45            
 Cys Glu Ile Lys Val His Ser Ala Asp Asn Thr Arg Met Glu Leu Ile
      50                  55                  60                
 Ile Pro Gly Glu Gln His Phe Tyr Met Lys Ala Val Asn Ala Ala Glu
  65                  70                  75                  80
 Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ser Lys Ala Cys Leu Thr
                  85                  90                  95    
 Asp Thr Arg Thr Lys Lys Glu Lys Glu Ile Ser Glu Thr Ser Glu Ser
             100                 105                 110        
 Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Met
         115                 120                 125            
 Gln Gln Val His Thr Ile Gln Glu Phe Val His His Asp Glu Asn His
     130                 135                 140                
 Ser Ser Pro Ser Ala Glu Asn Met Asn Glu Ala Ser Ser Leu Leu Ser
 145                 150                 155                 160
 Ala Thr Cys Asn Thr Phe Ile Thr Thr Leu Glu Glu Cys Val Lys Ile
                 165                 170                 175    
 Ala Asn Ala Lys Phe Lys Pro Glu Met Phe Gln Leu His His Pro Asp
             180                 185                 190        
 Pro Leu Val Ser Pro Val Ser Pro Ser Pro Val Gln Met Met Lys Arg
         195                 200                 205            
 Ser Val Ser His Pro Gly Ser Cys Ser Ser Glu Arg Ser Ser His Ser
     210                 215                 220                
 Ile Lys Glu Pro Val Ser Thr Leu His Arg Leu Ser Gln Arg Arg Arg
 225                 230                 235                 240
 Arg Thr Tyr Ser Asp Thr Asp Ser Cys Ser Asp Ile Pro Leu Glu Asp
                 245                 250                 255    
 Pro Asp Arg Pro Val His Cys Ser Lys Asn Thr Leu Asn Gly Asp Leu
             260                 265                 270        
 Ala Ser Ala Thr Ile Pro Glu Glu Ser Arg Leu Met Ala Lys Lys Gln
         275                 280                 285            
 Ser Glu Ser Glu Asp Thr Leu Pro Ser Phe Ser Ser
     290                 295                 300



      <210> 541
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 541
 Met Ala Gly Gln Phe Arg Ser Tyr Val Trp Asp Pro Leu Leu Ile Leu
   1               5                  10                  15    
 Ser Gln Ile Val Leu Met Gln Thr Val Tyr Tyr Gly Ser Leu Gly Leu
              20                  25                  30        
 Trp Leu Ala Leu Val Asp Gly Leu Val Arg Ser Ser Pro Ser Leu Asp
          35                  40                  45            
 Gln Met Phe Asp Ala Glu Ile Leu Gly Phe Ser Thr Pro Pro Gly Arg
      50                  55                  60                
 Leu Ser Met Met Ser Phe Ile Leu Asn Ala Leu Thr Cys Ala Leu Gly
  65                  70                  75                  80
 Leu Leu Tyr Phe Ile Arg Arg Gly Lys Gln Cys Leu Asp Phe Thr Val
                  85                  90                  95    
 Thr Val His Phe Phe His Leu Leu Gly Cys Trp Phe Tyr Ser Ser Arg
             100                 105                 110        
 Phe Pro Ser Ala Leu Thr Trp Trp Leu Val Gln Ala Val Cys Ile Ala
         115                 120                 125            
 Leu Met Ala Val Ile Gly Glu Tyr Leu Cys Met Arg Thr Glu Leu Lys
     130                 135                 140                
 Glu Ile Pro Leu Asn Ser Ala Pro Lys Ser Asn Val
 145                 150                 155    



      <210> 542
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 542
 Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln
   1               5                  10                  15    
 Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys
              20                  25                  30        
 Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys
          35                  40                  45            
 Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln
      50                  55                  60                
 Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn
  65                  70                  75                  80
 Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys
                  85                  90                  95    
 Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met
             100                 105                 110        
 Ile Lys Ala Phe Leu Pro Lys Met Leu Ala Gln Lys Ser Gly Asn Ile
         115                 120                 125            
 Ile Asn Met Ser Ser Val Ala Ser Ser Val Lys Gly Val Val Asn Arg
     130                 135                 140                
 Cys Val Tyr Ser Thr Thr Lys Ala Ala Val Ile Gly Leu Thr Lys Ser
 145                 150                 155                 160
 Val Ala Ala Asp Phe Ile Gln Gln Gly Ile Arg Cys Asn Cys Val Cys
                 165                 170                 175    
 Pro Gly Thr Val Asp Thr Pro Ser Leu Gln Glu Arg Ile Gln Ala Arg
             180                 185                 190        
 Gly Asn Pro Glu Glu Ala Arg Asn Asp Phe Leu Lys Arg Gln Lys Thr
         195                 200                 205            
 Gly Arg Phe Ala Thr Ala Glu Glu Ile Ala Met Leu Cys Val Tyr Leu
     210                 215                 220                
 Ala Ser Asp Glu Ser Ala Tyr Val Thr Gly Asn Pro Val Ile Ile Asp
 225                 230                 235                 240
 Gly Gly Trp Ser Leu
                 245



      <210> 543
      <211> 302
      <212> PRT
      <213> Homo sapiens


      <400> 543
 Met Leu Val Ile Lys Lys Gly Asn Thr Lys Asp Leu Gln Leu Ser Gly
   1               5                  10                  15    
 Phe Pro Val Val Gly Asn Leu Pro Ser Gln Pro Val Lys Asn Gly Thr
              20                  25                  30        
 Gly Pro Ser Val Tyr Lys Gly Leu Val Pro Lys Pro Ala Ala Pro Pro
          35                  40                  45            
 Thr Lys Pro Thr Gln Trp Lys Ser Gln Thr Lys Glu Asn Lys Val Gly
      50                  55                  60                
 Thr Ser Phe Pro His Glu Ser Thr Phe Gly Val Gly Asn Phe Asn Ala
  65                  70                  75                  80
 Phe Lys Ser Thr Ala Lys Asn Phe Ser Pro Ser Thr Asn Ser Val Lys
                  85                  90                  95    
 Glu Cys Asn Arg Ser Asn Ser Ser Ser Pro Val Asp Lys Leu Asn Gln
             100                 105                 110        
 Gln Pro Arg Leu Thr Lys Leu Thr Arg Met Arg Thr Asp Lys Lys Ser
         115                 120                 125            
 Glu Phe Leu Lys Ala Leu Lys Arg Asp Arg Val Glu Glu Glu His Glu
     130                 135                 140                
 Asp Glu Ser Arg Ala Gly Ser Glu Lys Asp Asp Asp Ser Phe Asn Leu
 145                 150                 155                 160
 His Asn Ser Asn Ser Thr His Gln Glu Arg Asp Ile Asn Arg Asn Phe
                 165                 170                 175    
 Asp Glu Asn Glu Ile Pro Gln Glu Asn Gly Asn Ala Ser Val Ile Ser
             180                 185                 190        
 Gln Gln Ile Ile Arg Ser Ser Thr Phe Pro Gln Thr Asp Val Leu Ser
         195                 200                 205            
 Ser Ser Leu Glu Ala Glu His Arg Leu Leu Lys Glu Met Gly Trp Gln
     210                 215                 220                
 Glu Asp Ser Glu Asn Asp Glu Thr Cys Ala Pro Leu Thr Glu Asp Glu
 225                 230                 235                 240
 Met Arg Glu Phe Gln Val Ile Ser Glu Gln Leu Gln Lys Asn Gly Leu
                 245                 250                 255    
 Arg Lys Asn Gly Ile Leu Lys Asn Gly Leu Ile Cys Asp Phe Lys Phe
             260                 265                 270        
 Gly Pro Trp Lys Asn Ser Thr Phe Lys Pro Thr Thr Glu Asn Asp Asp
         275                 280                 285            
 Thr Glu Thr Ser Ser Ser Asp Thr Ser Asp Asp Asp Asp Val
     290                 295                 300        



      <210> 544
      <211> 708
      <212> PRT
      <213> Homo sapiens


      <400> 544
 Met Ala Asn Glu Glu Asp Asp Pro Val Val Gln Glu Ile Asp Val Tyr
   1               5                  10                  15    
 Leu Ala Lys Ser Leu Ala Glu Lys Leu Tyr Leu Phe Gln Tyr Pro Val
              20                  25                  30        
 Arg Pro Ala Ser Met Thr Tyr Asp Asp Ile Pro His Leu Ser Ala Lys
          35                  40                  45            
 Ile Lys Pro Lys Gln Gln Lys Val Glu Leu Glu Met Ala Ile Asp Thr
      50                  55                  60                
 Leu Asn Pro Asn Tyr Cys Arg Ser Lys Gly Glu Gln Ile Ala Leu Asn
  65                  70                  75                  80
 Val Asp Gly Ala Cys Ala Asp Glu Thr Ser Thr Tyr Ser Ser Lys Leu
                  85                  90                  95    
 Met Asp Lys Gln Thr Phe Cys Ser Ser Gln Thr Thr Ser Asn Thr Ser
             100                 105                 110        
 Arg Tyr Ala Ala Ala Leu Tyr Arg Gln Gly Glu Leu His Leu Thr Pro
         115                 120                 125            
 Leu His Gly Ile Leu Gln Leu Arg Pro Ser Phe Ser Tyr Leu Asp Lys
     130                 135                 140                
 Ala Asp Ala Lys His Arg Glu Arg Glu Ala Ala Asn Glu Ala Gly Asp
 145                 150                 155                 160
 Ser Ser Gln Asp Glu Ala Glu Asp Asp Val Lys Gln Ile Thr Val Arg
                 165                 170                 175    
 Phe Ser Arg Pro Glu Ser Glu Gln Ala Arg Gln Arg Arg Val Gln Ser
             180                 185                 190        
 Tyr Glu Phe Leu Gln Lys Lys His Ala Glu Glu Pro Trp Val His Leu
         195                 200                 205            
 His Tyr Tyr Gly Leu Arg Asp Ser Arg Ser Glu His Glu Arg Gln Tyr
     210                 215                 220                
 Leu Leu Cys Pro Gly Ser Ser Gly Val Glu Asn Thr Glu Leu Val Lys
 225                 230                 235                 240
 Ser Pro Ser Glu Tyr Leu Met Met Leu Met Pro Pro Ser Gln Glu Glu
                 245                 250                 255    
 Glu Lys Asp Lys Pro Val Ala Pro Ser Asn Val Leu Ser Met Ala Gln
             260                 265                 270        
 Leu Arg Thr Leu Pro Leu Ala Asp Gln Ile Lys Ile Leu Met Lys Asn
         275                 280                 285            
 Val Lys Val Met Pro Phe Ala Asn Leu Met Ser Leu Leu Gly Pro Ser
     290                 295                 300                
 Ile Asp Ser Val Ala Val Leu Arg Gly Ile Gln Lys Val Ala Met Leu
 305                 310                 315                 320
 Val Gln Gly Asn Trp Val Val Lys Ser Asp Ile Leu Tyr Pro Lys Asp
                 325                 330                 335    
 Ser Ser Ser Pro His Ser Gly Val Pro Ala Glu Val Leu Cys Arg Gly
             340                 345                 350        
 Arg Asp Phe Val Met Trp Lys Phe Thr Gln Ser Arg Trp Val Val Arg
         355                 360                 365            
 Lys Glu Val Ala Thr Val Thr Lys Leu Cys Ala Glu Asp Val Lys Asp
     370                 375                 380                
 Phe Leu Glu His Met Ala Val Val Arg Ile Asn Lys Gly Trp Glu Phe
 385                 390                 395                 400
 Ile Leu Pro Tyr Asp Gly Glu Phe Ile Lys Lys His Pro Asp Val Val
                 405                 410                 415    
 Gln Arg Gln His Met Leu Trp Thr Gly Ile Gln Ala Lys Leu Glu Lys
             420                 425                 430        
 Val Tyr Asn Leu Val Lys Glu Thr Met Pro Lys Lys Pro Asp Ala Gln
         435                 440                 445            
 Ser Gly Pro Ala Gly Leu Val Cys Gly Asp Gln Arg Ile Gln Val Ala
     450                 455                 460                
 Lys Thr Lys Ala Gln Gln Asn His Ala Leu Leu Glu Arg Glu Leu Gln
 465                 470                 475                 480
 Arg Arg Lys Glu Gln Leu Arg Val Pro Ala Val Pro Pro Gly Val Arg
                 485                 490                 495    
 Ile Lys Glu Glu Pro Val Ser Glu Glu Gly Glu Glu Asp Glu Glu Gln
             500                 505                 510        
 Glu Ala Glu Glu Glu Pro Met Asp Thr Ser Pro Ser Gly Leu His Ser
         515                 520                 525            
 Lys Leu Ala Asn Gly Leu Pro Leu Gly Arg Ala Ala Gly Thr Asp Ser
     530                 535                 540                
 Phe Asn Gly His Pro Pro Gln Gly Cys Ala Ser Thr Pro Val Ala Arg
 545                 550                 555                 560
 Glu Leu Lys Ala Phe Val Glu Ala Thr Phe Gln Arg Gln Phe Val Leu
                 565                 570                 575    
 Thr Leu Ser Glu Leu Lys Arg Leu Phe Asn Leu His Leu Ala Ser Leu
             580                 585                 590        
 Pro Pro Gly His Thr Leu Phe Ser Gly Ile Ser Asp Arg Met Leu Gln
         595                 600                 605            
 Asp Thr Val Leu Ala Ala Gly Cys Lys Gln Ile Leu Val Pro Phe Pro
     610                 615                 620                
 Pro Gln Thr Ala Ala Ser Pro Asp Glu Gln Lys Val Phe Ala Leu Trp
 625                 630                 635                 640
 Glu Ser Gly Asp Met Ser Asp Gln His Arg Gln Val Leu Leu Glu Ile
                 645                 650                 655    
 Phe Ser Lys Asn Tyr Arg Val Arg Arg Asn Met Ile Gln Ser Arg Leu
             660                 665                 670        
 Thr Gln Glu Cys Gly Glu Asp Leu Ser Lys Gln Glu Val Asp Lys Val
         675                 680                 685            
 Leu Lys Asp Cys Cys Val Ser Tyr Gly Gly Met Trp Tyr Leu Lys Gly
     690                 695                 700                
 Thr Val Gln Ser
 705            



      <210> 545
      <211> 441
      <212> PRT
      <213> Homo sapiens


      <400> 545
 Met Arg Gly Leu Glu Glu Pro Gly Pro Arg Pro Thr Ala Thr Pro Cys
   1               5                  10                  15    
 Gly Cys Val Lys Pro Ala Leu Glu Thr Gly Asn Leu Leu Thr Glu Pro
              20                  25                  30        
 Val Gly Tyr Leu Glu Ser Cys Phe Ser Ala Lys Asn Gly Thr Pro Arg
          35                  40                  45            
 Gln Pro Ser Ile Cys Ser Tyr Ser Arg Ala Cys Leu Arg Ile Arg Lys
      50                  55                  60                
 Arg Ile Phe Asn Asn Pro Glu His Ser Leu Met Gly Leu Glu Gln Phe
  65                  70                  75                  80
 Ser His Val Trp Ile Leu Phe Val Phe His Lys Asn Gly His Leu Ser
                  85                  90                  95    
 Cys Lys Ala Lys Val Gln Pro Pro Arg Leu Asn Gly Ala Lys Thr Gly
             100                 105                 110        
 Val Phe Ser Thr Arg Ser Pro His Arg Pro Asn Ala Ile Gly Leu Thr
         115                 120                 125            
 Leu Ala Lys Leu Glu Lys Val Glu Gly Gly Ala Ile Tyr Leu Ser Gly
     130                 135                 140                
 Ile Asp Met Ile His Gly Thr Pro Val Leu Asp Ile Lys Pro Tyr Ile
 145                 150                 155                 160
 Ala Glu Tyr Asp Ser Pro Gln Asn Val Met Glu Pro Leu Ala Asp Phe
                 165                 170                 175    
 Asn Leu Gln Asn Asn Gln His Thr Pro Asn Thr Val Ser Gln Ser Asp
             180                 185                 190        
 Ser Lys Thr Asp Ser Cys Asp Gln Arg Gln Leu Ser Gly Cys Asp Glu
         195                 200                 205            
 Pro Gln Pro His His Ser Thr Lys Arg Lys Pro Lys Cys Pro Glu Asp
     210                 215                 220                
 Arg Thr Ser Glu Glu Asn Tyr Leu Thr His Ser Asp Thr Ala Arg Ile
 225                 230                 235                 240
 Gln Gln Ala Phe Pro Met His Arg Glu Ile Ala Val Asp Phe Gly Leu
                 245                 250                 255    
 Glu Ser Arg Arg Asp Gln Ser Ser Ser Val Ala Glu Glu Gln Ile Gly
             260                 265                 270        
 Pro Tyr Cys Pro Glu Lys Ser Phe Ser Glu Lys Gly Thr Asp Lys Lys
         275                 280                 285            
 Leu Glu Arg Val Glu Gly Ala Ala Val Leu Gln Gly Ser Arg Ala Glu
     290                 295                 300                
 Thr Gln Pro Met Ala Pro His Cys Pro Ala Gly Arg Ala Asp Gly Ala
 305                 310                 315                 320
 Pro Arg Ser Val Val Pro Ala Trp Val Thr Glu Ala Pro Val Ala Thr
                 325                 330                 335    
 Leu Glu Val Arg Phe Thr Pro His Ala Glu Met Asp Leu Gly Gln Leu
             340                 345                 350        
 Ser Ser Gln Asp Val Asp Gln Ala Ser Phe Lys Tyr Phe Gln Ser Ala
         355                 360                 365            
 Glu Glu Ala Lys Arg Ala Ile Glu Ala Val Leu Ser Ala Asp Pro Arg
     370                 375                 380                
 Ser Val Tyr Arg Arg Lys Leu Cys Gln Asp Arg Leu Phe Tyr Phe Thr
 385                 390                 395                 400
 Val Asp Ile Ala His Val Thr Cys Trp Phe Gly Asp Gly Phe Ala Glu
                 405                 410                 415    
 Val Leu Arg Ile Lys Pro Ala Ser Glu Pro Val His Met Thr Gly Pro
             420                 425                 430        
 Val Gly Ser Leu Val Ser Leu Gly Ser
         435                 440    



      <210> 546
      <211> 524
      <212> PRT
      <213> Homo sapiens


      <400> 546
 Met Ser Phe Ile Cys Gly Leu Gln Ser Ala Ala Arg Asn His Val Phe
   1               5                  10                  15    
 Phe Arg Phe Asn Ser Leu Ser Asn Trp Arg Lys Cys Asn Thr Leu Ala
              20                  25                  30        
 Ser Thr Ser Arg Gly Cys His Gln Val Gln Val Asn His Ile Val Asn
          35                  40                  45            
 Lys Tyr Gln Gly Leu Gly Val Asn Gln Cys Asp Arg Trp Ser Phe Leu
      50                  55                  60                
 Pro Gly Asn Phe His Phe Tyr Ser Thr Phe Asn Asn Lys Arg Thr Gly
  65                  70                  75                  80
 Gly Leu Ser Ser Thr Lys Ser Lys Glu Ile Trp Arg Ile Thr Ser Lys
                  85                  90                  95    
 Cys Thr Val Trp Asn Asp Ala Phe Ser Arg Gln Leu Leu Ile Lys Glu
             100                 105                 110        
 Val Thr Ala Val Pro Ser Leu Ser Val Leu His Pro Leu Ser Pro Ala
         115                 120                 125            
 Ser Ile Arg Ala Ile Arg Asn Phe His Thr Ser Pro Arg Phe Gln Ala
     130                 135                 140                
 Ala Pro Val Pro Leu Leu Leu Met Ile Leu Lys Pro Val Gln Lys Leu
 145                 150                 155                 160
 Phe Ala Ile Ile Val Gly Arg Gly Ile Arg Lys Trp Trp Gln Ala Leu
                 165                 170                 175    
 Pro Pro Asn Lys Lys Glu Val Val Lys Glu Asn Ile Arg Lys Asn Lys
             180                 185                 190        
 Trp Lys Leu Phe Leu Gly Leu Ser Ser Phe Gly Leu Leu Phe Val Val
         195                 200                 205            
 Phe Tyr Phe Thr His Leu Glu Val Ser Pro Ile Thr Gly Arg Ser Lys
     210                 215                 220                
 Leu Leu Leu Leu Gly Lys Glu Gln Phe Arg Leu Leu Ser Glu Leu Glu
 225                 230                 235                 240
 Tyr Glu Ala Trp Met Glu Glu Phe Lys Asn Asp Met Leu Thr Glu Lys
                 245                 250                 255    
 Asp Ala Arg Tyr Leu Ala Val Lys Glu Val Leu Cys His Leu Ile Glu
             260                 265                 270        
 Cys Asn Lys Asp Val Pro Gly Ile Ser Gln Ile Asn Trp Val Ile His
         275                 280                 285            
 Val Val Asp Ser Pro Ile Ile Asn Ala Phe Val Leu Pro Asn Gly Gln
     290                 295                 300                
 Met Phe Val Phe Thr Gly Phe Leu Asn Ser Val Thr Asp Ile His Gln
 305                 310                 315                 320
 Leu Ser Phe Leu Leu Gly His Glu Leu Ala His Ala Val Leu Gly His
                 325                 330                 335    
 Ala Ala Glu Lys Ala Gly Met Val His Leu Leu Asp Phe Leu Gly Met
             340                 345                 350        
 Ile Phe Leu Thr Met Ile Trp Ala Ile Cys Pro Arg Asp Ser Leu Ala
         355                 360                 365            
 Leu Leu Cys Gln Trp Ile Gln Ser Lys Leu Gln Glu Tyr Met Phe Asn
     370                 375                 380                
 Arg Pro Tyr Ser Arg Lys Leu Glu Ala Glu Ala Asp Lys Ile Gly Leu
 385                 390                 395                 400
 Leu Leu Ala Ala Lys Ala Cys Ala Asp Ile Arg Ala Ser Ser Val Phe
                 405                 410                 415    
 Trp Gln Gln Met Glu Phe Val Asp Ser Leu His Gly Gln Pro Lys Met
             420                 425                 430        
 Pro Glu Trp Leu Ser Thr His Pro Ser His Gly Asn Arg Val Glu Tyr
         435                 440                 445            
 Leu Asp Arg Leu Ile Pro Gln Ala Leu Lys Ile Arg Glu Met Cys Asn
     450                 455                 460                
 Cys Pro Pro Leu Ser Asn Pro Asp Pro Arg Leu Leu Phe Lys Leu Ser
 465                 470                 475                 480
 Thr Lys His Phe Leu Glu Glu Ser Glu Lys Glu Asp Leu Asn Ile Thr
                 485                 490                 495    
 Lys Lys Gln Lys Met Asp Thr Leu Pro Ile Gln Lys Gln Glu Gln Ile
             500                 505                 510        
 Pro Leu Thr Tyr Ile Val Glu Lys Arg Thr Gly Ser
         515                 520                



      <210> 547
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 547
 Met Ile Gly Ile Val Ser Val Val Ala Gly Ala Pro Ala Glu Met Ile
   1               5                  10                  15    
 Arg Glu Asp Asp Ile Ile Arg Lys Phe Arg Arg Lys Gly His Ile Ser
              20                  25                  30        
 Pro Gln Ser Gly Cys Val Leu Ala Val Ile Asp Trp Leu Gln Leu Leu
          35                  40                  45            
 Thr Leu Gly Leu Gly Gly Leu Arg Arg Gly Tyr Ser Pro Ser Phe Ser
      50                  55                  60                
 Ser Asp Thr Ala Asp Phe Ser Ile Val Gly Val Gly Gly Gly Gly Trp
  65                  70                  75                  80
 Met Ser Leu Gly Arg Asp Leu Gly Leu Ser Leu Ile Thr His Lys Asn
                  85                  90                  95    
 Ala Thr Leu Ala Glu Ser Arg Pro Val Ser Leu Ala Gly Ser Thr Thr
             100                 105                 110        
 Lys Lys Met Leu Phe Pro Ser Thr Val Ile
         115                 120        



      <210> 548
      <211> 605
      <212> PRT
      <213> Homo sapiens


      <400> 548
 Met Trp Leu His His Tyr Ser Leu Glu Met Tyr Gln Lys Met Gln Ser
   1               5                  10                  15    
 Pro His Ala Lys Leu Glu Val Leu His Tyr Arg Leu Ser Val Ser Ser
              20                  25                  30        
 Ala Leu Tyr Ser Pro Ala Gln Pro Ser Leu Gln Ala Leu His Ala Tyr
          35                  40                  45            
 Gln Glu Ser Phe Thr Pro Thr Glu Glu His Val Leu Val Val Arg Leu
      50                  55                  60                
 Leu Leu Lys His Leu His Ala Phe Ala Asn Ser Leu Lys Pro Glu Gln
  65                  70                  75                  80
 Ala Ser Pro Ser Ala His Ser His Ala Thr Ser Pro Leu Glu Glu Phe
                  85                  90                  95    
 Lys Arg Met Gly Leu Asn Leu Pro Glu Val Pro Ser Ala Leu Pro Arg
             100                 105                 110        
 Arg Ser Gln Pro Ser Leu Met Gly Ala Leu Gly Ser Ser Val Ser Arg
         115                 120                 125            
 Ala Ser Leu Leu Gly Lys Gln Gln Val Thr Leu Pro Ile Pro Cys Arg
     130                 135                 140                
 Ala Ala Val Pro Arg Phe Val Gln Gln Lys Leu Tyr Leu Phe Leu Gln
 145                 150                 155                 160
 His Cys Phe Gly His Trp Pro Leu Asp Ala Ser Phe Arg Ala Val Leu
                 165                 170                 175    
 Glu Met Trp Leu Ser Tyr Leu Gln Pro Trp Arg Tyr Ala Pro Asp Lys
             180                 185                 190        
 Gln Ala Pro Gly Ser Asp Ser Gln Pro Arg Cys Val Ser Glu Lys Trp
         195                 200                 205            
 Ala Pro Phe Val Gln Glu Asn Leu Leu Met Tyr Thr Lys Leu Phe Val
     210                 215                 220                
 Gly Phe Leu Asn Arg Ala Leu Arg Thr Asp Leu Val Ser Pro Lys His
 225                 230                 235                 240
 Ala Leu Met Val Phe Arg Val Ala Lys Val Phe Ala Gln Pro Asn Leu
                 245                 250                 255    
 Ala Glu Met Ile Gln Lys Gly Glu Gln Leu Phe Leu Glu Pro Glu Leu
             260                 265                 270        
 Val Ile Pro His Arg Gln His Arg Leu Phe Thr Ala Pro Thr Phe Thr
         275                 280                 285            
 Gly Ser Phe Leu Ser Pro Trp Pro Pro Ala Val Thr Asp Ala Ser Phe
     290                 295                 300                
 Lys Val Lys Ser His Val Tyr Ser Leu Glu Gly Gln Asp Cys Lys Tyr
 305                 310                 315                 320
 Thr Pro Met Phe Gly Pro Glu Ala Arg Thr Leu Val Leu Arg Leu Ala
                 325                 330                 335    
 Gln Leu Ile Thr Gln Ala Lys His Thr Ala Lys Ser Ile Ser Asp Gln
             340                 345                 350        
 Cys Ala Glu Ser Pro Ala Gly His Ser Phe Leu Ser Trp Leu Gly Phe
         355                 360                 365            
 Ser Ser Met Asp Thr Asn Gly Ser Tyr Thr Ala Asn Asp Leu Asp Glu
     370                 375                 380                
 Met Gly Gln Asp Ser Val Arg Lys Thr Asp Glu Tyr Leu Glu Lys Ala
 385                 390                 395                 400
 Leu Glu Tyr Leu Arg Gln Ile Phe Arg Leu Ser Glu Ala Gln Leu Arg
                 405                 410                 415    
 Gln Phe Thr Leu Ala Leu Gly Thr Thr Gln Asp Glu Asn Gly Lys Lys
             420                 425                 430        
 Gln Leu Pro Asp Cys Ile Val Gly Glu Asp Gly Leu Ile Leu Thr Pro
         435                 440                 445            
 Leu Gly Arg Tyr Gln Ile Ile Asn Gly Leu Arg Arg Phe Glu Ile Glu
     450                 455                 460                
 Tyr Gln Gly Asp Pro Lys Leu Gln Pro Ile Arg Ser Tyr Glu Ile Ala
 465                 470                 475                 480
 Ser Leu Val Arg Thr Leu Phe Arg Leu Ser Ser Ala Ile Asn His Arg
                 485                 490                 495    
 Phe Ala Gly Gln Met Ala Ala Leu Cys Ser Arg Asp Asp Phe Leu Gly
             500                 505                 510        
 Ser Phe Cys Arg Tyr His Leu Thr Glu Pro Gly Leu Ala Ser Arg His
         515                 520                 525            
 Leu Leu Ser Pro Val Gly Arg Arg Gln Val Ala Gly His Thr Arg Gly
     530                 535                 540                
 Pro Arg Leu Ser Leu Arg Phe Leu Gly Ser Tyr Arg Thr Leu Val Ser
 545                 550                 555                 560
 Leu Leu Leu Ala Phe Phe Val Ala Ser Leu Phe Cys Val Gly Pro Leu
                 565                 570                 575    
 Pro Cys Thr Leu Leu Leu Thr Leu Gly Tyr Val Leu Tyr Ala Ser Ala
             580                 585                 590        
 Met Thr Leu Leu Thr Glu Arg Gly Lys Leu His Gln Pro
         595                 600                 605



      <210> 549
      <211> 247
      <212> PRT
      <213> Homo sapiens


      <400> 549
 Met Gln Phe Gly Leu Leu Gly Thr Gly Phe Gln Leu Phe Gly Tyr Glu
   1               5                  10                  15    
 Glu Lys Leu Gln Ser Asn Pro Leu Gln His Leu Phe Glu Val Tyr Val
              20                  25                  30        
 Gln Val Asn Lys Glu Ala Ala Asp Asp Lys Ser Val Ala Lys Ala Ala
          35                  40                  45            
 Gln Glu Phe Phe Gln Arg Leu Glu Leu Gly Asp Val Gln Ala Leu Ser
      50                  55                  60                
 Leu Trp Gln Lys Phe Arg Asp Leu Ser Ile Glu Glu Tyr Ile Arg Val
  65                  70                  75                  80
 Tyr Lys Arg Leu Gly Val Tyr Phe Asp Glu Tyr Ser Gly Glu Ser Phe
                  85                  90                  95    
 Tyr Arg Glu Lys Ser Gln Glu Val Leu Lys Leu Leu Glu Ser Lys Gly
             100                 105                 110        
 Leu Leu Leu Lys Thr Ile Lys Gly Thr Ala Val Val Asp Leu Ser Gly
         115                 120                 125            
 Asn Gly Asp Pro Ser Ser Ile Cys Thr Val Met Arg Ser Asp Gly Thr
     130                 135                 140                
 Ser Leu Tyr Ala Thr Arg Asp Leu Ala Ala Ala Ile Asp Arg Met Asp
 145                 150                 155                 160
 Lys Tyr Asn Phe Asp Thr Met Ile Tyr Val Thr Asp Lys Gly Gln Lys
                 165                 170                 175    
 Lys His Phe Gln Gln Val Phe Gln Met Leu Lys Ile Met Gly Tyr Asp
             180                 185                 190        
 Trp Ala Glu Arg Cys Gln His Val Pro Phe Gly Val Val Gln Gly Met
         195                 200                 205            
 Lys Thr Arg Arg Gly Asp Val Thr Phe Leu Glu Asp Val Leu Asn Glu
     210                 215                 220                
 Ile Gln Leu Arg Met Leu Gln Asn Met Ala Ser Ile Lys Ser Glu Phe
 225                 230                 235                 240
 Ser Phe Phe Leu Leu Lys Ser
                 245        



      <210> 550
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 550
 Met Gln Phe Gly Leu Leu Gly Thr Gly Phe Gln Leu Phe Gly Tyr Glu
   1               5                  10                  15    
 Glu Lys Leu Gln Ser Asn Pro Leu Gln His Leu Phe Glu Val Tyr Val
              20                  25                  30        
 Gln Val Asn Lys Glu Ala Ala Asp Asp Lys Ser Val Ala Lys Ala Ala
          35                  40                  45            
 Gln Glu Phe Phe Gln Arg Leu Glu Leu Gly Asp Val Gln Ala Leu Ser
      50                  55                  60                
 Leu Trp Gln Lys Phe Arg Asp Leu Ser Ile Glu Glu Tyr Ile Arg Val
  65                  70                  75                  80
 Tyr Lys Arg Leu Gly Val Tyr Phe Asp Glu Tyr Ser Gly Glu Ser Phe
                  85                  90                  95    
 Tyr Arg Glu Lys Ser Gln Glu Val Leu Lys Leu Leu Glu Ser Lys Gly
             100                 105                 110        
 Leu Leu Leu Lys Thr Ile Lys Gly Thr Ala Val Val Asp Leu Ser Gly
         115                 120                 125            
 Asn Gly Asp Pro Ser Ser Ile Cys Thr Val Met Arg Ser Asp Gly Thr
     130                 135                 140                
 Ser Leu Tyr Ala Thr Arg Asp Leu Ala Ala Ala Ile Asp Arg Met Asp
 145                 150                 155                 160
 Lys Tyr Asn Phe Asp Thr Met Ile Tyr Val Thr Asp Lys Gly Gln Lys
                 165                 170                 175    
 Lys His Phe Gln Gln Val Phe Gln Met Leu Lys Ile Met Gly Tyr Asp
             180                 185                 190        
 Trp Ala Glu Arg Cys Gln His Val Pro Phe Gly Val Val Gln Gly Met
         195                 200                 205            
 Lys Thr Arg Arg Gly Asp Val Thr Phe Leu Glu Asp Val Leu Asn Glu
     210                 215                 220                
 Ile Gln Leu Arg Met Leu Gln Asn Met Ala Ser Ile Lys Thr Thr Lys
 225                 230                 235                 240
 Glu Leu Lys Asn Pro Gln Glu Thr Ala Glu Arg Val Gly Leu Ala Ala
                 245                 250                 255    
 Leu Ile Ile Gln Asp Phe Lys Gly Leu Leu Leu Ser Asp Tyr Lys Phe
             260                 265                 270        
 Ser Trp Asp Arg Val Phe Gln Ser Arg Gly Asp Thr Gly Val Phe Leu
         275                 280                 285            
 Gln Tyr Thr His Ala Arg Leu His Ser Leu Glu Glu Thr Phe Gly Cys
     290                 295                 300                
 Gly Tyr Leu Asn Asp Phe Asn Thr Ala Cys Leu Gln Glu Pro Gln Ser
 305                 310                 315                 320
 Val Ser Ile Leu Gln His Leu Leu Arg Phe Asp Glu Val Leu Tyr Lys
                 325                 330                 335    
 Ser Ser Gln Asp Phe Gln Pro Arg His Ile Val Ser Tyr Leu Leu Thr
             340                 345                 350        
 Leu Ser His Leu Ala Ala Val Ala His Lys Thr Leu Gln Ile Lys Asp
         355                 360                 365            
 Ser Pro Pro Glu Val Ala Gly Ala Arg Leu His Leu Phe Lys Ala Val
     370                 375                 380                
 Arg Ser Val Leu Ala Asn Gly Met Lys Leu Leu Gly Ile Thr Pro Val
 385                 390                 395                 400
 Cys Arg Met
            



      <210> 551
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 551
 Met Ile Phe Gly Ala Cys Ala Gly Leu Ile Gly Gln Ser Ala Ser Tyr
   1               5                  10                  15    
 Pro Leu Asp Val Val Arg Arg Arg Met Gln Thr Ala Gly Val Thr Gly
              20                  25                  30        
 Tyr Pro Arg Ala Ser Ile Ala Arg Thr Leu Arg Thr Ile Val Arg Glu
          35                  40                  45            
 Glu Gly Ala Val Arg Gly Leu Tyr Lys Gly Leu Ser Met Asn Trp Val
      50                  55                  60                
 Lys Gly Pro Ile Ala Val Gly Ile Ser Phe Thr Thr Phe Asp Leu Met
  65                  70                  75                  80
 Gln Ile Leu Leu Arg His Leu Gln Ser
                  85                



      <210> 552
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 552
 Met Pro Gly Phe Thr Cys Cys Val Pro Gly Cys Tyr Asn Asn Ser His
   1               5                  10                  15    
 Arg Asp Lys Ala Leu His Phe Tyr Thr Phe Pro Lys Asp Ala Glu Leu
              20                  25                  30        
 Arg Arg Leu Trp Leu Lys Asn Val Ser Arg Ala Gly Val Ser Gly Cys
          35                  40                  45            
 Phe Ser Thr Phe Gln Pro Thr Thr Gly His Arg Leu Cys Ser Val His
      50                  55                  60                
 Phe Gln Gly Gly Arg Lys Thr Tyr Thr Val Arg Val Pro Thr Ile Phe
  65                  70                  75                  80
 Pro Leu Arg Gly Val Asn Glu Arg Lys Val Ala Arg Arg Pro Ala Gly
                  85                  90                  95    
 Ala Ala Ala Ala Arg Arg Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln
             100                 105                 110        
 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
         115                 120                 125            
 Gln Gln Gln Gln Ser Ser Pro Ser Ala Ser Thr Ala Gln Thr Ala Gln
     130                 135                 140                
 Leu Gln Pro Asn Leu Val Ser Ala Ser Ala Ala Val Leu Leu Thr Leu
 145                 150                 155                 160
 Gln Ala Thr Val Asp Ser Ser Gln Ala Pro Gly Ser Val Gln Pro Ala
                 165                 170                 175    
 Pro Ile Thr Pro Thr Gly Glu Asp Val Lys Pro Ile Asp Leu Thr Val
             180                 185                 190        
 Gln Val Glu Phe Ala Ala Ala Glu Gly Ala Ala Ala Ala Ala Ala Ala
         195                 200                 205            
 Ser Glu Leu Gln Ala Ala Thr Ala Gly Leu Glu Ala Ala Glu Cys Pro
     210                 215                 220                
 Met Gly Pro Gln Leu Val Val Val Gly Glu Glu Gly Phe Pro Asp Thr
 225                 230                 235                 240
 Gly Ser Asp His Ser Tyr Ser Leu Ser Ser Gly Thr Thr Glu Glu Glu
                 245                 250                 255    
 Leu Leu Arg Lys Leu Asn Glu Gln Arg Asp Ile Leu Ala Leu Met Glu
             260                 265                 270        
 Val Lys Met Lys Glu Met Lys Gly Ser Ile Arg His Leu Arg Leu Thr
         275                 280                 285            
 Glu Ala Lys Leu Arg Glu Glu Leu Arg Glu Lys Asp Arg Leu Leu Ala
     290                 295                 300                
 Met Ala Val Ile Arg Lys Lys His Gly Met
 305                 310                



      <210> 553
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 553
 Met Gln Thr Leu Ser Ser Thr Thr Ser Gly Thr Leu Ile Arg Phe Ser
   1               5                  10                  15    
 Ser Ser Cys Thr Ser Lys Phe Val Ser Ala Thr Pro Trp Gly Gly Ser
              20                  25                  30        
 Thr Gly Ser Pro Pro Ser Leu Pro Val Pro Gly Gly Leu Ser Gly Phe
          35                  40                  45            
 Pro Lys Glu Ser Ser Phe Pro Arg Asp Gln Lys Pro Glu Leu Thr Leu
      50                  55                  60                
 Pro Cys Val Gln Val Gly Leu Ser Thr Thr Leu Leu Cys Thr Thr Trp
  65                  70                  75                  80
 Met Pro Tyr Ala Cys Cys Trp Gly Lys Pro Leu Arg Thr Leu Cys Phe
                  85                  90                  95    
 Leu Trp Asp Met Ser Ser Ala Gln Ile Trp Pro Pro
             100                 105            



      <210> 554
      <211> 291
      <212> PRT
      <213> Homo sapiens


      <400> 554
 Met Asp Phe Glu Asn Leu Phe Ser Lys Pro Pro Asn Pro Ala Leu Gly
   1               5                  10                  15    
 Lys Thr Ala Thr Asp Ser Asp Glu Arg Ile Asp Asp Glu Ile Asp Thr
              20                  25                  30        
 Glu Val Glu Glu Thr Gln Glu Glu Lys Ile Lys Leu Glu Cys Glu Gln
          35                  40                  45            
 Ile Pro Lys Lys Phe Arg His Ser Ala Ile Ser Pro Lys Ser Ser Leu
      50                  55                  60                
 His Arg Lys Ser Arg Ser Lys Asp Tyr Asp Val Tyr Ser Asp Asn Asp
  65                  70                  75                  80
 Ile Cys Ser Gln Glu Ser Glu Asp Asn Phe Ala Lys Glu Leu Gln Gln
                  85                  90                  95    
 Tyr Ile Gln Ala Arg Glu Met Ala Asn Ala Ala Gln Pro Glu Glu Ser
             100                 105                 110        
 Thr Lys Lys Glu Gly Val Lys Asp Thr Pro Gln Ala Ala Lys Gln Lys
         115                 120                 125            
 Asn Lys Asn Leu Lys Ala Gly His Lys Asn Gly Lys Gln Lys Lys Met
     130                 135                 140                
 Lys Arg Lys Trp Pro Gly Pro Gly Asn Lys Gly Ser Asn Ala Leu Leu
 145                 150                 155                 160
 Arg Asn Ser Gly Ser Gln Glu Glu Asp Gly Lys Pro Lys Glu Lys Gln
                 165                 170                 175    
 Gln His Leu Ser Gln Ala Phe Ile Asn Gln His Thr Val Glu Arg Lys
             180                 185                 190        
 Gly Lys Gln Ile Cys Lys Tyr Phe Leu Glu Arg Lys Cys Ile Lys Gly
         195                 200                 205            
 Asp Gln Cys Lys Phe Asp His Asp Ala Glu Ile Glu Lys Lys Lys Glu
     210                 215                 220                
 Met Cys Lys Phe Tyr Val Gln Gly Tyr Cys Thr Arg Gly Glu Asn Cys
 225                 230                 235                 240
 Leu Tyr Leu His Asn Glu Tyr Pro Cys Lys Phe Tyr His Thr Gly Thr
                 245                 250                 255    
 Lys Cys Tyr Gln Gly Glu Tyr Cys Lys Phe Ser His Ala Pro Leu Thr
             260                 265                 270        
 Pro Glu Thr Gln Glu Leu Leu Ala Lys Val Leu Asp Thr Glu Lys Lys
         275                 280                 285            
 Ser Cys Lys
     290    



      <210> 555
      <211> 583
      <212> PRT
      <213> Homo sapiens


      <400> 555
 Met Ala Asn Thr Val Glu Ala Asp Gly Ser Asn Asp Glu Gly Tyr Glu
   1               5                  10                  15    
 Ala Ala Glu Glu Gly Leu Gly Asp Glu Asp Glu Lys Arg Lys Ile Ser
              20                  25                  30        
 Ala Ile Arg Ser Tyr Arg Asp Val Met Lys Leu Cys Ala Ala His Leu
          35                  40                  45            
 Pro Thr Glu Ser Asp Ala Pro Asn His Tyr Gln Ala Val Cys Arg Ala
      50                  55                  60                
 Leu Phe Ala Glu Thr Met Glu Leu His Thr Phe Leu Thr Lys Ile Lys
  65                  70                  75                  80
 Ser Ala Lys Glu Asn Leu Lys Lys Ile Gln Glu Met Glu Lys Ser Asp
                  85                  90                  95    
 Glu Ser Ser Thr Asp Leu Glu Glu Leu Lys Asn Ala Asp Trp Ala Arg
             100                 105                 110        
 Phe Trp Val Gln Val Met Arg Asp Leu Arg Asn Gly Val Lys Leu Lys
         115                 120                 125            
 Lys Val Gln Glu Arg Gln Tyr Asn Pro Leu Pro Ile Glu Tyr Gln Leu
     130                 135                 140                
 Thr Pro Tyr Glu Met Leu Met Asp Asp Ile Arg Cys Lys Arg Tyr Thr
 145                 150                 155                 160
 Leu Arg Lys Val Met Val Asn Gly Asp Ile Pro Pro Arg Leu Lys Lys
                 165                 170                 175    
 Ser Ala His Glu Ile Ile Leu Asp Phe Ile Arg Ser Arg Pro Pro Leu
             180                 185                 190        
 Asn Pro Val Ser Ala Arg Lys Leu Lys Pro Thr Pro Pro Arg Pro Arg
         195                 200                 205            
 Ser Leu His Glu Arg Ile Leu Glu Glu Ile Lys Ala Glu Arg Lys Leu
     210                 215                 220                
 Arg Pro Val Ser Pro Glu Glu Ile Arg Arg Ser Arg Leu Asp Val Thr
 225                 230                 235                 240
 Thr Pro Glu Ser Thr Lys Asn Leu Val Glu Ser Ser Met Val Asn Gly
                 245                 250                 255    
 Gly Leu Thr Ser Gln Thr Lys Glu Asn Gly Leu Ser Thr Ser Gln Gln
             260                 265                 270        
 Val Pro Ala Gln Arg Lys Lys Leu Leu Arg Ala Pro Thr Leu Ala Glu
         275                 280                 285            
 Leu Asp Ser Ser Glu Ser Glu Glu Glu Thr Leu His Lys Ser Thr Ser
     290                 295                 300                
 Ser Ser Ser Val Ser Pro Ser Phe Pro Glu Glu Pro Val Leu Glu Ala
 305                 310                 315                 320
 Val Ser Thr Arg Lys Lys Pro Pro Lys Phe Leu Pro Ile Ser Ser Thr
                 325                 330                 335    
 Pro Gln Pro Glu Arg Arg Gln Pro Pro Gln Arg Arg His Ser Ile Glu
             340                 345                 350        
 Lys Glu Thr Pro Thr Asn Val Arg Gln Phe Leu Pro Pro Ser Arg Gln
         355                 360                 365            
 Ser Ser Arg Ser Leu Glu Glu Phe Cys Tyr Pro Val Glu Cys Leu Ala
     370                 375                 380                
 Leu Thr Val Glu Glu Val Met His Ile Arg Gln Val Leu Val Lys Ala
 385                 390                 395                 400
 Glu Leu Glu Lys Tyr Gln Gln Tyr Lys Asp Ile Tyr Thr Ala Leu Lys
                 405                 410                 415    
 Lys Gly Lys Leu Cys Phe Cys Cys Arg Thr Arg Arg Phe Ser Phe Phe
             420                 425                 430        
 Thr Trp Ser Tyr Thr Cys Gln Phe Cys Lys Arg Pro Val Cys Ser Gln
         435                 440                 445            
 Cys Cys Lys Lys Met Arg Leu Pro Ser Lys Pro Tyr Ser Thr Leu Pro
     450                 455                 460                
 Ile Phe Ser Leu Gly Pro Ser Ala Leu Gln Arg Gly Glu Ser Ser Met
 465                 470                 475                 480
 Arg Ser Glu Lys Pro Ser Thr Ala His His Arg Pro Leu Arg Ser Ile
                 485                 490                 495    
 Ala Arg Phe Ser Ser Lys Ser Lys Ser Met Asp Lys Ser Asp Glu Glu
             500                 505                 510        
 Leu Gln Phe Pro Lys Glu Leu Met Glu Asp Trp Ser Thr Met Glu Val
         515                 520                 525            
 Cys Val Asp Cys Lys Lys Phe Ile Ser Glu Ile Ile Ser Ser Ser Arg
     530                 535                 540                
 Arg Ser Leu Val Leu Ala Asn Lys Arg Ala Arg Leu Lys Arg Lys Thr
 545                 550                 555                 560
 Gln Ser Phe Tyr Met Ser Ser Pro Gly Pro Ser Glu Tyr Cys Pro Ser
                 565                 570                 575    
 Glu Arg Thr Ile Ser Glu Ile
             580            



      <210> 556
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 556
 Met Leu Arg Glu Pro Gly Asp Pro Glu Lys Leu Gly Glu Phe Leu Gln
   1               5                  10                  15    
 Lys Asp Asn Ile Ser Val His Tyr Phe Cys Leu Ile Leu Ser Ser Lys
              20                  25                  30        
 Leu Pro Gln Arg Gly Gln Ser Asn Arg Gly Phe His Gly Phe Leu Pro
          35                  40                  45            
 Glu Asp Ile Lys Lys Glu Ala Ala Arg Ala Ser Arg Lys Ile Cys Phe
      50                  55                  60                
 Val Cys Lys Lys Lys Gly Ala Ala Ile Asn Cys Gln Lys Asp Gln Cys
  65                  70                  75                  80
 Leu Arg Asn Phe His Leu Pro Cys Gly Gln Glu Arg Gly Cys Leu Ser
                  85                  90                  95    
 Gln Phe Phe Gly Glu Tyr Lys Ser Phe Cys Asp Lys His Arg Pro Thr
             100                 105                 110        
 Gln Asn Ile Gln His Gly His Val Gly Glu Glu Ser Cys Ile Leu Cys
         115                 120                 125            
 Cys Glu Asp Leu Ser Gln Gln Ser Val Glu Asn Ile Gln Ser Pro Cys
     130                 135                 140                
 Cys Ser Gln Ala Ile Tyr His Arg Lys Cys Ile Gln Lys Tyr Ala His
 145                 150                 155                 160
 Thr Ser Ala Lys His Phe Phe Lys Cys Pro Gln Cys Asn Asn Arg Lys
                 165                 170                 175    
 Glu Phe Pro Gln Glu Met Leu Arg Met Gly Ile His Ile Pro Asp Arg
             180                 185                 190        





      <210> 557
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 557
 Met Glu Ser Pro Lys Cys Leu Tyr Ser Arg Ile Thr Val Asn Thr Ala
   1               5                  10                  15    
 Phe Gly Thr Lys Phe Ser His Ile Ser Phe Ile Ile Leu Phe Lys Val
              20                  25                  30        
 Phe Leu Phe Pro Arg Ile Thr Ile Ser Lys Lys Thr Lys Leu Val Thr
          35                  40                  45            
 Leu Ser Asn Tyr Leu Asn Lys
      50                  55



      <210> 558
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 558
 Met Ala Glu Val Glu Glu Thr Leu Lys Arg Leu Gln Ser Gln Lys Gly
   1               5                  10                  15    
 Val Gln Gly Ile Ile Val Val Asn Thr Glu Gly Ile Pro Ile Lys Ser
              20                  25                  30        
 Thr Met Asp Asn Pro Thr Thr Thr Gln Tyr Ala Ser Leu Met His Ser
          35                  40                  45            
 Phe Ile Leu Lys Ala Arg Ser Thr Val Arg Asp Ile Asp Pro Gln Asn
      50                  55                  60                
 Asp Leu Thr Phe Leu Arg Ile Arg Ser Lys Lys Asn Glu Ile Met Val
  65                  70                  75                  80
 Ala Pro Asp Lys Asp Tyr Phe Leu Ile Val Ile Gln Asn Pro Thr Glu
                  85                  90                  95    





      <210> 559
      <211> 354
      <212> PRT
      <213> Homo sapiens


      <400> 559
 Met Arg His Ser Leu Thr Lys Leu Leu Ala Ala Ser Gly Ser Asn Ser
   1               5                  10                  15    
 Pro Thr Arg Ser Glu Ser Pro Glu Pro Ala Ala Thr Cys Ser Leu Pro
              20                  25                  30        
 Ser Asp Leu Thr Arg Ala Ala Ala Gly Glu Glu Glu Thr Ala Ala Ala
          35                  40                  45            
 Gly Ser Pro Gly Arg Lys Gln Gln Phe Gly Asp Glu Gly Glu Leu Glu
      50                  55                  60                
 Ala Gly Arg Gly Ser Arg Gly Gly Val Ala Val Arg Ala Pro Ser Pro
  65                  70                  75                  80
 Glu Glu Met Glu Glu Glu Ala Ile Ala Ser Leu Pro Gly Glu Glu Thr
                  85                  90                  95    
 Glu Asp Met Asp Phe Leu Ser Gly Leu Glu Leu Ala Asp Leu Leu Asp
             100                 105                 110        
 Pro Arg Gln Pro Asp Trp His Leu Asp Pro Gly Leu Ser Ser Pro Gly
         115                 120                 125            
 Pro Leu Ser Ser Ser Gly Gly Gly Ser Asp Ser Gly Gly Leu Trp Arg
     130                 135                 140                
 Gly Asp Asp Asp Asp Glu Ala Ala Ala Ala Glu Met Gln Arg Phe Ser
 145                 150                 155                 160
 Asp Leu Leu Gln Arg Leu Leu Asn Gly Ile Gly Gly Cys Ser Ser Ser
                 165                 170                 175    
 Ser Asp Ser Gly Ser Ala Glu Lys Arg Arg Arg Lys Ser Pro Gly Gly
             180                 185                 190        
 Gly Gly Gly Gly Gly Ser Gly Asn Asp Asn Asn Gln Ala Ala Thr Lys
         195                 200                 205            
 Ser Pro Arg Lys Ala Ala Ala Ala Ala Ala Arg Leu Asn Arg Leu Lys
     210                 215                 220                
 Lys Lys Glu Tyr Val Met Gly Leu Glu Ser Arg Val Arg Gly Leu Ala
 225                 230                 235                 240
 Ala Glu Asn Gln Glu Leu Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg
                 245                 250                 255    
 Val Gln Ala Leu Gln Glu Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala
             260                 265                 270        
 Asn Glu Thr Gly Leu Ala Arg Leu Leu Ser Arg Leu Ser Gly Val Gly
         275                 280                 285            
 Leu Arg Leu Thr Thr Ser Leu Phe Arg Asp Ser Pro Ala Gly Asp His
     290                 295                 300                
 Asp Tyr Ala Leu Pro Val Gly Lys Gln Lys Gln Asp Leu Leu Glu Glu
 305                 310                 315                 320
 Asp Asp Ser Ala Gly Gly Val Cys Leu His Val Asp Lys Asp Lys Val
                 325                 330                 335    
 Ser Val Glu Phe Cys Ser Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu
             340                 345                 350        
 Lys Met
        



      <210> 560
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 560
 Met Asn Ser Arg Gln Ala Trp Arg Leu Phe Leu Ser Gln Gly Arg Gly
   1               5                  10                  15    
 Asp Arg Trp Val Ser Arg Pro Arg Gly His Phe Ser Pro Ala Leu Arg
              20                  25                  30        
 Arg Glu Phe Phe Thr Thr Thr Thr Lys Glu Gly Tyr Asp Arg Arg Pro
          35                  40                  45            
 Val Asp Ile Thr Pro Leu Glu Gln Arg Lys Leu Thr Phe Asp Thr His
      50                  55                  60                
 Ala Leu Val Gln Asp Leu Glu Thr His Gly Phe Asp Lys Thr Gln Ala
  65                  70                  75                  80
 Glu Thr Ile Val Ser Ala Leu Thr Ala Leu Ser Asn Val Ser Leu Asp
                  85                  90                  95    
 Thr Ile Tyr Lys Glu Met Val Thr Gln Ala Gln Gln Glu Ile Thr Val
             100                 105                 110        
 Gln Gln Leu Met Ala His Leu Asp Ala Ile Arg Lys Asp Met Val Ile
         115                 120                 125            
 Leu Glu Lys Ser Glu Phe Ala Asn Leu Arg Ala Glu Asn Glu Lys Met
     130                 135                 140                
 Lys Ile Glu Leu Asp Gln Val Lys Gln Gln Leu Met His Glu Thr Ser
 145                 150                 155                 160
 Arg Ile Arg Ala Asp Asn Lys Leu Asp Ile Asn Leu Glu Arg Ser Arg
                 165                 170                 175    
 Val Thr Asp Met Phe Thr Asp Gln Glu Lys Gln Leu Met Glu Thr Thr
             180                 185                 190        
 Thr Glu Phe Thr Lys Lys Asp Thr Gln Thr Lys Ser Ile Ile Ser Glu
         195                 200                 205            
 Thr Ser Asn Lys Ile Asp Ala Glu Ile Ala Ser Leu Lys Thr Leu Met
     210                 215                 220                
 Glu Ser Asn Lys Leu Glu Thr Ile Arg Tyr Leu Ala Ala Ser Val Phe
 225                 230                 235                 240
 Thr Cys Leu Ala Ile Ala Leu Gly Phe Tyr Arg Phe Trp Lys
                 245                 250                



      <210> 561
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 561
 Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala Gly Ser Cys Phe Arg
   1               5                  10                  15    
 Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg Leu Thr Arg Ser Ser
              20                  25                  30        
 Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys Pro Gln Glu Ser Pro
          35                  40                  45            
 Gly Ala Pro Ser Arg Thr Tyr Asn Arg Val Pro Leu His Lys Pro Thr
      50                  55                  60                
 Asp Trp Gln Lys Lys Ile Leu Ile Trp Ser Gly Arg Phe Lys Lys Glu
  65                  70                  75                  80
 Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met Leu Asp Ala Ala Lys
                  85                  90                  95    
 Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met Ile Ala Leu Thr Val
             100                 105                 110        
 Val Gly Cys Ile Phe Met Val Ile Glu Gly Lys Lys Ala Ala Gln Arg
         115                 120                 125            
 His Glu Thr Leu Thr Ser Leu Asn Leu Glu Lys Lys Ala Arg Leu Lys
     130                 135                 140                
 Glu Glu Ala Ala Met Lys Ala Lys Thr Glu
 145                 150                



      <210> 562
      <211> 47
      <212> PRT
      <213> Homo sapiens


      <400> 562
 Met His Phe Leu Val Val Ile Trp Asn Gln Ala Ser Ile Asn Tyr Tyr
   1               5                  10                  15    
 Thr Ser Arg Gly Ala Leu Asp Leu Ser Ser Glu Glu Gly Trp His Leu
              20                  25                  30        
 Phe Arg Phe Asn Arg Glu Glu Leu Leu Asp Met Ala Trp Glu Glu
          35                  40                  45        



      <210> 563
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 563
 Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser Leu Asn Ile Phe Pro
   1               5                  10                  15    
 Ser Val Ala Ile Asn Lys Ser Ser Gly Ala Pro Arg Arg Val Pro Ala
              20                  25                  30        
 Gln Gly Ser Ile Lys Asp His Thr Ala Gly Leu Arg Leu Thr Ala Leu
          35                  40                  45            
 Ser Pro Glu His Gln Ser Pro Ala Glu Ser Gly Asp Asn Thr Ser Ser
      50                  55                  60                
 Leu Gln Arg Gly Thr Ser Pro Pro Ala Ala Thr Ser Leu Arg Leu Leu
  65                  70                  75                  80
 Leu Ser Ser Lys Asp Ser Leu Gly Phe Lys Cys His Phe Pro Cys Phe
                  85                  90                  95    
 Arg Asp Pro Gly Val Leu Ile Ala
             100                



      <210> 564
      <211> 3909
      <212> PRT
      <213> Homo sapiens


      <400> 564
 Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln
   1               5                  10                  15    
 His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu
              20                  25                  30        
 Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala
          35                  40                  45            
 Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr
      50                  55                  60                
 His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu
  65                  70                  75                  80
 Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu
                  85                  90                  95    
 Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val
             100                 105                 110        
 Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn
         115                 120                 125            
 Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp
     130                 135                 140                
 Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu
 145                 150                 155                 160
 Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala
                 165                 170                 175    
 Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr
             180                 185                 190        
 Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly
         195                 200                 205            
 Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala
     210                 215                 220                
 Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met
 225                 230                 235                 240
 Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val
                 245                 250                 255    
 Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala
             260                 265                 270        
 Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp
         275                 280                 285            
 Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg
     290                 295                 300                
 Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile
 305                 310                 315                 320
 Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu
                 325                 330                 335    
 Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val
             340                 345                 350        
 Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu
         355                 360                 365            
 Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr
     370                 375                 380                
 Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr
 385                 390                 395                 400
 Val Phe Lys Arg Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn
                 405                 410                 415    
 Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala
             420                 425                 430        
 His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys
         435                 440                 445            
 Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr
     450                 455                 460                
 Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr
 465                 470                 475                 480
 Thr Ile Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly
                 485                 490                 495    
 Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile
             500                 505                 510        
 Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu
         515                 520                 525            
 Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly
     530                 535                 540                
 Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn
 545                 550                 555                 560
 Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly
                 565                 570                 575    
 Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser
             580                 585                 590        
 Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala
         595                 600                 605            
 Gly Asn Glu Leu Asp Leu Phe Ser Leu Asn Pro Asn Ser Gly Val Leu
     610                 615                 620                
 Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe
 625                 630                 635                 640
 His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro
                 645                 650                 655    
 Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu
             660                 665                 670        
 Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu
         675                 680                 685            
 Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe
     690                 695                 700                
 Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu
 705                 710                 715                 720
 Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val
                 725                 730                 735    
 Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu
             740                 745                 750        
 Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp
         755                 760                 765            
 Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr
     770                 775                 780                
 Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro
 785                 790                 795                 800
 Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn
                 805                 810                 815    
 Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser
             820                 825                 830        
 Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp
         835                 840                 845            
 Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Leu Thr Asp
     850                 855                 860                
 Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala
 865                 870                 875                 880
 Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu
                 885                 890                 895    
 Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val
             900                 905                 910        
 Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile
         915                 920                 925            
 Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr
     930                 935                 940                
 Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly
 945                 950                 955                 960
 Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val
                 965                 970                 975    
 Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu
             980                 985                 990        
 Lys Lys Gln Val Tyr Asn Leu Thr Val Arg Ala Lys Asp Lys Gly Lys
         995                1000                1005            
 Pro Val Ser Leu Ser Ser Thr Cys Tyr Val Glu Val Glu Val Val Asp
    1010                1015                1020                
 Val Asn Glu Asn Leu His Pro Pro Val Phe Ser Ser Phe Val Glu Lys
1025                1030                1035                1040
 Gly Thr Val Lys Glu Asp Ala Pro Val Gly Ser Leu Val Met Thr Val
                1045                1050                1055    
 Ser Ala His Asp Glu Asp Ala Gly Arg Asp Gly Glu Ile Arg Tyr Ser
            1060                1065                1070        
 Ile Arg Asp Gly Ser Gly Val Gly Val Phe Lys Ile Gly Glu Glu Thr
        1075                1080                1085            
 Gly Val Ile Glu Thr Ser Asp Arg Leu Asp Arg Glu Ser Thr Ser His
    1090                1095                1100                
 Tyr Trp Leu Thr Val Phe Ala Thr Asp Gln Gly Val Val Pro Leu Ser
1105                1110                1115                1120
 Ser Phe Ile Glu Ile Tyr Ile Glu Val Glu Asp Val Asn Asp Asn Ala
                1125                1130                1135    
 Pro Gln Thr Ser Glu Pro Val Tyr Tyr Pro Glu Ile Met Glu Asn Ser
            1140                1145                1150        
 Pro Lys Asp Val Ser Val Val Gln Ile Glu Ala Phe Asp Pro Asp Ser
        1155                1160                1165            
 Ser Ser Asn Asp Lys Leu Met Tyr Lys Ile Thr Ser Gly Asn Pro Gln
    1170                1175                1180                
 Gly Phe Phe Ser Ile His Pro Lys Thr Gly Leu Ile Thr Thr Thr Ser
1185                1190                1195                1200
 Arg Lys Leu Asp Arg Glu Gln Gln Asp Glu His Ile Leu Glu Val Thr
                1205                1210                1215    
 Val Thr Asp Asn Gly Ser Pro Pro Lys Ser Thr Ile Ala Arg Val Ile
            1220                1225                1230        
 Val Lys Ile Leu Asp Glu Asn Asp Asn Lys Pro Gln Phe Leu Gln Lys
        1235                1240                1245            
 Phe Tyr Lys Ile Arg Leu Pro Glu Arg Glu Lys Pro Asp Arg Glu Arg
    1250                1255                1260                
 Asn Ala Arg Arg Glu Pro Leu Tyr Arg Val Ile Ala Thr Asp Lys Asp
1265                1270                1275                1280
 Glu Gly Pro Asn Ala Glu Ile Ser Tyr Ser Ile Glu Asp Gly Asn Glu
                1285                1290                1295    
 His Gly Lys Phe Phe Ile Glu Pro Lys Thr Gly Val Val Ser Ser Lys
            1300                1305                1310        
 Arg Phe Ser Ala Ala Gly Glu Tyr Asp Ile Leu Ser Ile Lys Ala Val
        1315                1320                1325            
 Asp Asn Gly Arg Pro Gln Lys Ser Ser Thr Thr Arg Leu His Ile Glu
    1330                1335                1340                
 Trp Ile Ser Lys Pro Lys Gln Ser Leu Glu Pro Ile Ser Phe Glu Glu
1345                1350                1355                1360
 Ser Phe Phe Thr Phe Thr Val Met Glu Ser Asp Pro Val Ala His Met
                1365                1370                1375    
 Ile Gly Val Ile Ser Val Glu Pro Pro Gly Ile Pro Leu Trp Phe Asp
            1380                1385                1390        
 Ile Thr Gly Gly Asn Tyr Asp Ser His Phe Asp Val Asp Lys Gly Thr
        1395                1400                1405            
 Gly Thr Ile Ile Val Ala Lys Pro Leu Asp Ala Glu Gln Lys Ser Asn
    1410                1415                1420                
 Tyr Asn Leu Thr Val Glu Ala Thr Asp Gly Thr Thr Thr Ile Leu Thr
1425                1430                1435                1440
 Gln Val Phe Ile Lys Val Ile Asp Thr Asn Asp His Arg Pro Gln Phe
                1445                1450                1455    
 Ser Thr Ser Lys Tyr Glu Val Val Ile Pro Glu Asp Thr Ala Pro Glu
            1460                1465                1470        
 Thr Glu Ile Leu Gln Ile Ser Ala Val Asp Gln Asp Glu Lys Asn Lys
        1475                1480                1485            
 Leu Ile Tyr Thr Leu Gln Ser Ser Arg Asp Pro Leu Ser Leu Lys Lys
    1490                1495                1500                
 Phe Arg Leu Asp Pro Ala Thr Gly Ser Leu Tyr Thr Ser Glu Lys Leu
1505                1510                1515                1520
 Asp His Glu Ala Val Ser Pro Ala His Leu Thr Val Met Val Arg Asp
                1525                1530                1535    
 Gln Asp Val Pro Val Lys Arg Asn Phe Ala Arg Ile Val Val Asn Val
            1540                1545                1550        
 Ser Asp Thr Asn Asp His Ala Pro Trp Phe Thr Ala Ser Ser Tyr Lys
        1555                1560                1565            
 Gly Arg Val Tyr Glu Ser Ala Ala Val Gly Ser Val Val Leu Gln Val
    1570                1575                1580                
 Thr Ala Leu Asp Lys Asp Lys Gly Lys Asn Ala Glu Val Leu Tyr Ser
1585                1590                1595                1600
 Ile Glu Ser Gly Asn Ile Gly Asn Ile Gly Asn Ser Phe Met Ile Asp
                1605                1610                1615    
 Pro Val Leu Gly Ser Ile Lys Thr Ala Lys Glu Leu Asp Arg Ser Asn
            1620                1625                1630        
 Gln Ala Glu Tyr Asp Leu Met Val Lys Ala Thr Asp Lys Gly Ser Pro
        1635                1640                1645            
 Pro Met Ser Glu Ile Thr Ser Val Arg Ile Phe Val Thr Ile Ala Asp
    1650                1655                1660                
 Asn Ala Ser Pro Lys Phe Thr Ser Lys Glu Tyr Ser Val Glu Leu Ser
1665                1670                1675                1680
 Glu Thr Val Ser Ile Gly Ser Phe Val Gly Met Val Thr Ala His Ser
                1685                1690                1695    
 Gln Ser Ser Val Val Tyr Glu Ile Lys Asp Gly Asn Thr Gly Asp Ala
            1700                1705                1710        
 Phe Asp Ile Asn Pro His Ser Gly Thr Ile Ile Thr Gln Lys Ala Leu
        1715                1720                1725            
 Asp Phe Glu Thr Leu Pro Ile Tyr Thr Leu Ile Ile Gln Gly Thr Asn
    1730                1735                1740                
 Met Ala Gly Leu Ser Thr Asn Thr Thr Val Leu Val His Leu Gln Asp
1745                1750                1755                1760
 Glu Asn Asp Asn Ala Pro Val Phe Met Gln Ala Glu Tyr Thr Gly Leu
                1765                1770                1775    
 Ile Ser Glu Ser Ala Ser Ile Asn Ser Val Val Leu Thr Asp Arg Asn
            1780                1785                1790        
 Val Pro Leu Val Ile Arg Ala Ala Asp Ala Asp Lys Asp Ser Asn Ala
        1795                1800                1805            
 Leu Leu Val Tyr His Ile Val Glu Pro Ser Val His Thr Tyr Phe Ala
    1810                1815                1820                
 Ile Asp Ser Ser Thr Gly Ala Ile His Thr Val Leu Ser Leu Asp Tyr
1825                1830                1835                1840
 Glu Glu Thr Ser Ile Phe His Phe Thr Val Gln Val His Asp Met Gly
                1845                1850                1855    
 Thr Pro Arg Leu Phe Ala Glu Tyr Ala Ala Asn Val Thr Val His Val
            1860                1865                1870        
 Ile Asp Ile Asn Asp Cys Pro Pro Val Phe Ala Lys Pro Leu Tyr Glu
        1875                1880                1885            
 Ala Ser Leu Leu Leu Pro Thr Tyr Lys Gly Val Lys Val Ile Thr Val
    1890                1895                1900                
 Asn Ala Thr Asp Ala Asp Ser Ser Ala Phe Ser Gln Leu Ile Tyr Ser
1905                1910                1915                1920
 Ile Thr Glu Gly Asn Ile Gly Glu Lys Phe Ser Met Asp Tyr Lys Thr
                1925                1930                1935    
 Gly Ala Leu Thr Val Gln Asn Thr Thr Gln Leu Arg Ser Arg Tyr Glu
            1940                1945                1950        
 Leu Thr Val Arg Ala Ser Asp Gly Arg Phe Ala Gly Leu Thr Ser Val
        1955                1960                1965            
 Lys Ile Asn Val Lys Glu Ser Lys Glu Ser His Leu Lys Phe Thr Gln
    1970                1975                1980                
 Asp Val Tyr Ser Ala Val Val Lys Glu Asn Ser Thr Glu Ala Glu Thr
1985                1990                1995                2000
 Leu Ala Val Ile Thr Ala Ile Gly Ser Pro Ile Asn Glu Pro Leu Phe
                2005                2010                2015    
 Tyr His Ile Leu Asn Pro Asp Arg Arg Phe Lys Ile Ser Arg Thr Ser
            2020                2025                2030        
 Gly Val Leu Ser Thr Thr Gly Thr Pro Phe Asp Arg Glu Gln Gln Glu
        2035                2040                2045            
 Ala Phe Asp Val Val Val Glu Val Ile Glu Glu His Lys Pro Ser Ala
    2050                2055                2060                
 Val Ala His Val Val Val Lys Val Ile Val Glu Asp Gln Asn Asp Asn
2065                2070                2075                2080
 Ala Pro Val Phe Val Asn Leu Pro Tyr Tyr Ala Val Val Lys Val Asp
                2085                2090                2095    
 Thr Glu Val Gly His Val Ile Arg Tyr Val Thr Ala Val Asp Arg Asp
            2100                2105                2110        
 Ser Gly Arg Asn Gly Glu Val His Tyr Tyr Leu Lys Glu His His Glu
        2115                2120                2125            
 His Phe Gln Ile Gly Pro Leu Gly Glu Ile Ser Leu Lys Lys Gln Phe
    2130                2135                2140                
 Glu Leu Asp Thr Leu Asn Lys Glu Tyr Leu Val Thr Val Val Ala Lys
2145                2150                2155                2160
 Asp Gly Gly Asn Pro Ala Phe Ser Ala Glu Val Ile Val Pro Ile Thr
                2165                2170                2175    
 Val Met Asn Lys Ala Met Pro Val Phe Glu Lys Pro Phe Tyr Ser Ala
            2180                2185                2190        
 Glu Ile Ala Glu Ser Ile Gln Val His Ser Pro Val Val His Val Gln
        2195                2200                2205            
 Ala Asn Ser Pro Glu Gly Leu Lys Val Phe Tyr Ser Ile Thr Asp Gly
    2210                2215                2220                
 Asp Pro Phe Ser Gln Phe Thr Ile Asn Phe Asn Thr Gly Val Ile Asn
2225                2230                2235                2240
 Val Ile Ala Pro Leu Asp Phe Glu Ala His Pro Ala Tyr Lys Leu Ser
                2245                2250                2255    
 Ile Arg Ala Thr Asp Ser Leu Thr Gly Ala His Ala Glu Val Phe Val
            2260                2265                2270        
 Asp Ile Ile Val Asp Asp Ile Asn Asp Asn Pro Pro Val Phe Ala Gln
        2275                2280                2285            
 Gln Ser Tyr Ala Val Thr Leu Ser Glu Ala Ser Val Ile Gly Thr Ser
    2290                2295                2300                
 Val Val Gln Val Arg Ala Thr Asp Ser Asp Ser Glu Pro Asn Arg Gly
2305                2310                2315                2320
 Ile Ser Tyr Gln Met Phe Gly Asn His Ser Lys Ser His Asp His Phe
                2325                2330                2335    
 His Val Asp Ser Ser Thr Gly Leu Ile Ser Leu Leu Arg Thr Leu Asp
            2340                2345                2350        
 Tyr Glu Gln Ser Arg Gln His Thr Ile Phe Val Arg Ala Val Asp Gly
        2355                2360                2365            
 Gly Met Pro Thr Leu Ser Ser Asp Val Ile Val Thr Val Asp Val Thr
    2370                2375                2380                
 Asp Leu Asn Gly Asn Pro Pro Leu Phe Glu Gln Gln Ile Tyr Glu Ala
2385                2390                2395                2400
 Arg Ile Ser Glu His Ala Pro His Gly His Phe Val Thr Cys Val Lys
                2405                2410                2415    
 Ala Tyr Asp Ala Asp Ser Ser Asp Ile Asp Lys Leu Gln Tyr Ser Ile
            2420                2425                2430        
 Leu Ser Gly Asn Asp His Lys His Phe Val Ile Asp Ser Ala Thr Gly
        2435                2440                2445            
 Ile Ile Thr Leu Ser Asn Leu His Arg His Ala Leu Lys Pro Phe Tyr
    2450                2455                2460                
 Ser Leu Asn Leu Ser Val Ser Asp Gly Val Phe Arg Ser Ser Thr Gln
2465                2470                2475                2480
 Val His Val Thr Val Ile Gly Gly Asn Leu His Ser Pro Ala Phe Leu
                2485                2490                2495    
 Gln Asn Glu Tyr Glu Val Glu Leu Ala Glu Asn Ala Pro Leu His Thr
            2500                2505                2510        
 Leu Val Met Glu Val Lys Thr Thr Asp Gly Asp Ser Gly Ile Tyr Gly
        2515                2520                2525            
 His Val Thr Tyr His Ile Val Asn Asp Phe Ala Lys Asp Arg Phe Tyr
    2530                2535                2540                
 Ile Asn Glu Arg Gly Gln Ile Phe Thr Leu Glu Lys Leu Asp Arg Glu
2545                2550                2555                2560
 Thr Pro Ala Glu Lys Val Ile Ser Val Arg Leu Met Ala Lys Asp Ala
                2565                2570                2575    
 Gly Gly Lys Val Ala Phe Cys Thr Val Asn Val Ile Leu Thr Asp Asp
            2580                2585                2590        
 Asn Asp Asn Ala Pro Gln Phe Arg Ala Thr Lys Tyr Glu Val Asn Ile
        2595                2600                2605            
 Gly Ser Ser Ala Ala Lys Gly Thr Ser Val Val Lys Ser Ala Ser Asp
    2610                2615                2620                
 Ala Asp Glu Gly Ser Asn Ala Asp Ile Thr Tyr Ala Ile Glu Ala Asp
2625                2630                2635                2640
 Ser Glu Ser Val Lys Glu Asn Leu Glu Ile Asn Lys Leu Ser Gly Val
                2645                2650                2655    
 Ile Thr Thr Lys Glu Ser Leu Ile Gly Leu Glu Asn Glu Phe Phe Thr
            2660                2665                2670        
 Phe Phe Val Arg Ala Val Asp Asn Gly Ser Pro Ser Lys Glu Ser Val
        2675                2680                2685            
 Val Leu Val Tyr Val Lys Ile Leu Pro Pro Glu Met Gln Leu Pro Lys
    2690                2695                2700                
 Phe Ser Glu Pro Phe Tyr Thr Phe Thr Val Ser Glu Asp Val Pro Val
2705                2710                2715                2720
 Gly Thr Glu Ile Asp Leu Ile Arg Ala Glu His Ser Gly Thr Val Leu
                2725                2730                2735    
 Tyr Ser Leu Val Lys Gly Asn Thr Pro Glu Ser Asn Arg Asp Glu Ser
            2740                2745                2750        
 Phe Val Ile Asp Arg Gln Ser Gly Arg Leu Lys Leu Glu Lys Ser Leu
        2755                2760                2765            
 Asp His Glu Thr Thr Lys Trp Tyr Gln Phe Ser Ile Leu Ala Arg Cys
    2770                2775                2780                
 Thr Gln Asp Asp His Glu Met Val Ala Ser Val Asp Val Ser Ile Gln
2785                2790                2795                2800
 Val Lys Asp Ala Asn Asp Asn Ser Pro Val Phe Glu Ser Ser Pro Tyr
                2805                2810                2815    
 Glu Ala Phe Ile Val Glu Asn Leu Pro Gly Gly Ser Arg Val Ile Gln
            2820                2825                2830        
 Ile Arg Ala Ser Asp Ala Asp Ser Gly Thr Asn Gly Gln Val Met Tyr
        2835                2840                2845            
 Ser Leu Asp Gln Ser Gln Ser Val Glu Val Ile Glu Ser Phe Ala Ile
    2850                2855                2860                
 Asn Met Glu Thr Gly Trp Ile Thr Thr Leu Lys Glu Leu Asp His Glu
2865                2870                2875                2880
 Lys Arg Asp Asn Tyr Gln Ile Lys Val Val Ala Ser Asp His Gly Glu
                2885                2890                2895    
 Lys Ile Gln Leu Ser Ser Thr Ala Ile Val Asp Val Thr Val Thr Asp
            2900                2905                2910        
 Val Asn Asp Ser Pro Pro Arg Phe Thr Ala Glu Ile Tyr Lys Gly Thr
        2915                2920                2925            
 Val Ser Glu Asp Asp Pro Gln Gly Gly Val Ile Ala Ile Leu Ser Thr
    2930                2935                2940                
 Thr Asp Ala Asp Ser Glu Glu Ile Asn Arg Gln Val Thr Tyr Phe Ile
2945                2950                2955                2960
 Thr Gly Gly Asp Pro Leu Gly Gln Phe Ala Val Glu Thr Ile Gln Asn
                2965                2970                2975    
 Glu Trp Lys Val Tyr Val Lys Lys Pro Leu Asp Arg Glu Lys Arg Asp
            2980                2985                2990        
 Asn Tyr Leu Leu Thr Ile Thr Ala Thr Asp Gly Thr Phe Ser Ser Lys
        2995                3000                3005            
 Ala Ile Val Glu Val Lys Val Leu Asp Ala Asn Asp Asn Ser Pro Val
    3010                3015                3020                
 Cys Glu Lys Thr Leu Tyr Ser Asp Thr Ile Pro Glu Asp Val Leu Pro
3025                3030                3035                3040
 Gly Lys Leu Ile Met Gln Ile Ser Ala Thr Asp Ala Asp Ile Arg Ser
                3045                3050                3055    
 Asn Ala Glu Ile Thr Tyr Thr Leu Leu Gly Ser Gly Ala Glu Lys Phe
            3060                3065                3070        
 Lys Leu Asn Pro Asp Thr Gly Glu Leu Lys Thr Ser Thr Pro Leu Asp
        3075                3080                3085            
 Arg Glu Glu Gln Ala Val Tyr His Leu Leu Val Arg Ala Thr Asp Gly
    3090                3095                3100                
 Gly Gly Arg Phe Cys Gln Ala Ser Ile Val Val Thr Leu Glu Asp Val
3105                3110                3115                3120
 Asn Asp Asn Ala Pro Glu Phe Ser Ala Asp Pro Tyr Ala Ile Thr Val
                3125                3130                3135    
 Phe Glu Asn Thr Glu Pro Gly Thr Leu Leu Thr Arg Val Gln Ala Thr
            3140                3145                3150        
 Asp Ala Asp Ala Gly Leu Asn Arg Lys Ile Leu Tyr Ser Leu Ile Asp
        3155                3160                3165            
 Ser Ala Asp Gly Gln Phe Ser Ile Asn Glu Leu Ser Gly Ile Ile Gln
    3170                3175                3180                
 Leu Glu Lys Pro Leu Asp Arg Glu Leu Gln Ala Val Tyr Thr Leu Ser
3185                3190                3195                3200
 Leu Lys Ala Val Asp Gln Gly Leu Pro Arg Arg Leu Thr Ala Thr Gly
                3205                3210                3215    
 Thr Val Ile Val Ser Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe
            3220                3225                3230        
 Glu Tyr Arg Glu Tyr Gly Ala Thr Val Ser Glu Asp Ile Leu Val Gly
        3235                3240                3245            
 Thr Glu Val Leu Gln Val Tyr Ala Ala Ser Arg Asp Ile Glu Ala Asn
    3250                3255                3260                
 Ala Glu Ile Thr Tyr Ser Ile Ile Ser Gly Asn Glu His Gly Lys Phe
3265                3270                3275                3280
 Ser Ile Asp Ser Lys Thr Gly Ala Val Phe Ile Ile Glu Asn Leu Asp
                3285                3290                3295    
 Tyr Glu Ser Ser His Glu Tyr Tyr Leu Thr Val Glu Ala Thr Asp Gly
            3300                3305                3310        
 Gly Thr Pro Ser Leu Ser Asp Val Ala Thr Val Asn Val Asn Val Thr
        3315                3320                3325            
 Asp Ile Asn Asp Asn Thr Pro Val Phe Ser Gln Asp Thr Tyr Thr Thr
    3330                3335                3340                
 Val Ile Ser Glu Asp Ala Val Leu Glu Gln Ser Val Ile Thr Val Met
3345                3350                3355                3360
 Ala Asp Asp Ala Asp Gly Pro Ser Asn Ser His Ile His Tyr Ser Ile
                3365                3370                3375    
 Ile Asp Gly Asn Gln Gly Ser Ser Phe Thr Ile Asp Pro Val Arg Gly
            3380                3385                3390        
 Glu Val Lys Val Thr Lys Leu Leu Asp Arg Glu Thr Ile Ser Gly Tyr
        3395                3400                3405            
 Thr Leu Thr Val Gln Ala Ser Asp Asn Gly Ser Pro Pro Arg Val Asn
    3410                3415                3420                
 Thr Thr Thr Val Asn Ile Asp Val Ser Asp Val Asn Asp Asn Ala Pro
3425                3430                3435                3440
 Val Phe Ser Arg Gly Asn Tyr Ser Val Ile Ile Gln Glu Asn Lys Pro
                3445                3450                3455    
 Val Gly Phe Ser Val Leu Gln Leu Val Val Thr Asp Glu Asp Ser Ser
            3460                3465                3470        
 His Asn Gly Pro Pro Phe Phe Phe Thr Ile Val Thr Gly Asn Asp Glu
        3475                3480                3485            
 Lys Ala Phe Glu Val Asn Pro Gln Gly Val Leu Leu Thr Ser Ser Ala
    3490                3495                3500                
 Ile Lys Arg Lys Glu Lys Asp His Tyr Leu Leu Gln Val Lys Val Ala
3505                3510                3515                3520
 Asp Asn Gly Lys Pro Gln Leu Ser Ser Leu Thr Tyr Ile Asp Ile Arg
                3525                3530                3535    
 Val Ile Glu Glu Ser Ile Tyr Pro Pro Ala Ile Leu Pro Leu Glu Ile
            3540                3545                3550        
 Phe Ile Thr Ser Ser Gly Glu Glu Tyr Ser Gly Gly Val Ile Gly Lys
        3555                3560                3565            
 Ile His Ala Thr Asp Gln Asp Val Tyr Asp Thr Leu Thr Tyr Ser Leu
    3570                3575                3580                
 Asp Pro Gln Met Asp Asn Leu Phe Ser Val Ser Ser Thr Gly Gly Lys
3585                3590                3595                3600
 Leu Ile Ala His Lys Lys Leu Asp Ile Gly Gln Tyr Leu Leu Asn Val
                3605                3610                3615    
 Ser Val Thr Asp Gly Lys Phe Thr Thr Val Ala Asp Ile Thr Val His
            3620                3625                3630        
 Ile Arg Gln Val Thr Gln Glu Met Leu Asn His Thr Ile Ala Ile Arg
        3635                3640                3645            
 Phe Ala Asn Leu Thr Pro Glu Glu Phe Val Gly Asp Tyr Trp Arg Asn
    3650                3655                3660                
 Phe Gln Arg Ala Leu Arg Asn Ile Leu Gly Val Arg Arg Asn Asp Ile
3665                3670                3675                3680
 Gln Ile Val Ser Leu Gln Ser Ser Glu Pro His Pro His Leu Asp Val
                3685                3690                3695    
 Leu Leu Phe Val Glu Lys Pro Gly Ser Ala Gln Ile Ser Thr Lys Gln
            3700                3705                3710        
 Leu Leu His Lys Ile Asn Ser Ser Val Thr Asp Ile Glu Glu Ile Ile
        3715                3720                3725            
 Gly Val Arg Ile Leu Asn Val Phe Gln Lys Leu Cys Ala Gly Leu Asp
    3730                3735                3740                
 Cys Pro Trp Lys Phe Cys Asp Glu Lys Val Ser Val Asp Glu Ser Val
3745                3750                3755                3760
 Met Ser Thr His Ser Thr Ala Arg Leu Ser Phe Val Thr Pro Arg His
                3765                3770                3775    
 His Arg Ala Ala Val Cys Leu Cys Lys Glu Gly Arg Cys Pro Pro Val
            3780                3785                3790        
 His His Gly Cys Glu Asp Asp Pro Cys Pro Glu Gly Ser Glu Cys Val
        3795                3800                3805            
 Ser Asp Pro Trp Glu Glu Lys His Thr Cys Val Cys Pro Ser Gly Arg
    3810                3815                3820                
 Phe Gly Gln Cys Pro Gly Ser Ser Ser Met Thr Leu Thr Gly Asn Ser
3825                3830                3835                3840
 Tyr Val Lys Tyr Arg Leu Thr Glu Asn Glu Asn Lys Leu Glu Met Lys
                3845                3850                3855    
 Leu Thr Met Arg Leu Arg Thr Tyr Ser Thr His Ala Val Val Met Tyr
            3860                3865                3870        
 Ala Arg Gly Thr Asp Tyr Ser Ile Leu Glu Ile His His Gly Arg Leu
        3875                3880                3885            
 Gln Tyr Lys Phe Asp Cys Gly Thr Trp Pro Trp Asn Cys Leu Cys Ser
    3890                3895                3900                
 Glu His Ser Gly Gln
3905                



      <210> 565
      <211> 348
      <212> PRT
      <213> Homo sapiens


      <400> 565
 Met Gly Ser Arg Ala Leu Arg Leu Trp Leu Val Ala Pro Gly Gly Gly
   1               5                  10                  15    
 Ile Lys Trp Arg Phe Ile Ala Thr Ser Pro Ala Ser Gln Leu Ser Pro
              20                  25                  30        
 Thr Glu Leu Thr Glu Met Arg Asn Asp Leu Phe Asn Lys Glu Lys Ala
          35                  40                  45            
 Arg Gln Leu Ser Leu Thr Pro Arg Thr Glu Lys Ile Glu Val Lys His
      50                  55                  60                
 Val Gly Lys Thr Asp Pro Gly Thr Val Phe Val Met Asn Lys Asn Ile
  65                  70                  75                  80
 Ser Thr Pro Tyr Ser Cys Ala Met His Leu Ser Glu Trp Tyr Cys Arg
                  85                  90                  95    
 Lys Ser Ile Leu Ala Leu Val Asp Gly Gln Pro Trp Asp Met Tyr Lys
             100                 105                 110        
 Pro Leu Thr Lys Ser Cys Glu Ile Lys Phe Leu Thr Phe Lys Asp Cys
         115                 120                 125            
 Asp Pro Gly Glu Val Asn Lys Ala Tyr Trp Arg Ser Cys Ala Met Met
     130                 135                 140                
 Met Gly Cys Val Ile Glu Arg Ala Phe Lys Asp Glu Tyr Met Val Asn
 145                 150                 155                 160
 Leu Val Arg Ala Pro Glu Val Pro Val Ile Ser Gly Ala Phe Cys Tyr
                 165                 170                 175    
 Asp Val Val Leu Asp Ser Lys Leu Asp Glu Trp Met Pro Thr Lys Glu
             180                 185                 190        
 Asn Leu Arg Ser Phe Thr Lys Asp Ala His Ala Leu Ile Tyr Lys Asp
         195                 200                 205            
 Leu Pro Phe Glu Thr Leu Glu Val Glu Ala Lys Val Ala Leu Glu Ile
     210                 215                 220                
 Phe Gln His Ser Lys Tyr Lys Val Asp Phe Ile Glu Glu Lys Ala Ser
 225                 230                 235                 240
 Gln Asn Pro Glu Arg Ile Val Lys Leu His Arg Ile Gly Asp Phe Ile
                 245                 250                 255    
 Asp Val Ser Glu Gly Pro Leu Ile Pro Arg Thr Ser Ile Cys Phe Gln
             260                 265                 270        
 Tyr Glu Val Ser Ala Val His Asn Leu Gln Pro Thr Gln Pro Ser Leu
         275                 280                 285            
 Ile Arg Arg Phe Gln Gly Val Ser Leu Pro Val His Leu Arg Ala His
     290                 295                 300                
 Phe Thr Ile Trp Asp Lys Leu Leu Glu Arg Ser Arg Lys Met Thr Pro
 305                 310                 315                 320
 Phe Pro Ile Leu Leu Leu Phe Thr Thr Gln Ser Phe Phe Thr Thr Ser
                 325                 330                 335    
 Pro Glu Ser Tyr Leu Leu His Gly Thr Val Ser Glu
             340                 345            



      <210> 566
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 566
 Met Thr Ala Arg Gly Thr Pro Ser Arg Phe Leu Ala Ser Val Leu His
   1               5                  10                  15    
 Asn Gly Leu Gly Arg Tyr Val Gln Gln Leu Gln Arg Leu Ser Phe Ser
              20                  25                  30        
 Val Ser Arg Asp Gly Ala Ser Ser Arg Gly Ala Arg Glu Phe Val Glu
          35                  40                  45            
 Arg Glu Val Ile Asp Phe Ala Arg Arg Asn Pro Gly Val Val Ile Tyr
      50                  55                  60                
 Val Asn Ser Arg Pro Cys Cys Val Pro Arg Val Val Ala Glu Tyr Leu
  65                  70                  75                  80
 Asn Gly Ala Val Arg Glu Glu Ser Ile His Cys Lys Ser Val Glu Glu
                  85                  90                  95    
 Ile Ser Thr Leu Val Gln Lys Leu Ala Asp Gln Ser Gly Leu Asp Val
             100                 105                 110        
 Ile Arg Ile Arg Lys Pro Phe His Thr Asp Asn Pro Ser Ile Gln Gly
         115                 120                 125            
 Gln Trp His Pro Phe Thr Asn Lys Pro Thr Thr Phe Arg Gly Leu Arg
     130                 135                 140                
 Pro Arg Glu Val Gln Asp Pro Ala Pro Ala Gln Asp Thr Gly Leu Arg
 145                 150                 155                 160
 Leu Ser Ala Val Ala Pro Gln Ile Leu Leu Pro Gly Trp Pro Asp Pro
                 165                 170                 175    
 Ile Ser Val Gln Ser Ser Asp Leu Pro Trp Gly Asn Thr His Tyr Arg
             180                 185                 190        
 Pro Glu Pro Leu Ser Ser Thr Thr Trp Leu
         195                 200        



      <210> 567
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 567
 Met Ala Glu Val Glu Ala Pro Thr Ala Ala Glu Thr Asp Met Lys Gln
   1               5                  10                  15    
 Tyr Gln Gly Ser Gly Gly Val Ala Met Asp Val Glu Arg Ser Arg Phe
              20                  25                  30        
 Pro Tyr Cys Val Val Trp Thr Pro Ile Pro Val Leu Thr Trp Phe Phe
          35                  40                  45            
 Pro Ile Ile Gly His Met Gly Ile Cys Thr Ser Thr Gly Val Ile Arg
      50                  55                  60                
 Asp Phe Ala Gly Pro Tyr Phe Val Ser Glu Asp Asn Met Ala Phe Gly
  65                  70                  75                  80
 Lys Pro Ala Lys Tyr Trp Lys Leu Asp Pro Ala Gln Val Tyr Ala Ser
                  85                  90                  95    
 Gly Pro Asn Ala Trp Asp Thr Ala Val His Asp Ala Ser Glu Glu Tyr
             100                 105                 110        
 Lys His Arg Met His Asn Leu Cys Cys Asp Asn Cys His Ser His Val
         115                 120                 125            
 Ala Leu Ala Leu Asn Leu Met Arg Tyr Asn Asn Ser Thr Asn Trp Asn
     130                 135                 140                
 Met Val Thr Leu Cys Phe Phe Cys Leu Leu Tyr Gly Lys Tyr Val Ser
 145                 150                 155                 160
 Val Gly Ala Phe Val Lys Thr Trp Leu Pro Phe Ile Leu Leu Leu Gly
                 165                 170                 175    
 Ile Ile Leu Thr Val Ser Leu Val Phe Asn Leu Arg
             180                 185            



      <210> 568
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 568
 Met Ala Arg Gly Gly Val Ser Ala Arg Val Leu Leu Gln Ala Ala Arg
   1               5                  10                  15    
 Gly Thr Trp Trp Asn Arg Pro Gly Gly Thr Ser Gly Ser Gly Glu Gly
              20                  25                  30        
 Val Ala Leu Gly Thr Thr Arg Lys Phe Gln Ala Thr Gly Ser Arg Pro
          35                  40                  45            
 Ala Gly Glu Glu Asp Ala Gly Gly Pro Glu Arg Pro Gly Asp Val Val
      50                  55                  60                
 Asn Val Val Phe Val Asp Arg Ser Gly Gln Arg Ile Pro Val Ser Gly
  65                  70                  75                  80
 Arg Val Gly Asp Asn Val Leu His Leu Ala Gln Arg His Gly Val Asp
                  85                  90                  95    
 Leu Glu Gly Ala Cys Glu Ala Ser Leu Ala Cys Ser Thr Cys His Val
             100                 105                 110        
 Tyr Val Ser Glu Asp His Leu Asp Leu Leu Pro Pro Pro Glu Glu Arg
         115                 120                 125            
 Glu Asp Asp Met Leu Asp Met Ala Pro Leu Leu Gln Glu Asn Ser Arg
     130                 135                 140                
 Leu Gly Cys Gln Ile Val Leu Thr Pro Glu Leu Glu Gly Ala Glu Phe
 145                 150                 155                 160
 Thr Leu Pro Lys Ile Thr Arg Asn Phe Tyr Val Asp Gly His Val Pro
                 165                 170                 175    
 Lys Pro His
            



      <210> 569
      <211> 204
      <212> PRT
      <213> Homo sapiens


      <400> 569
 Met Glu Leu Lys Gln Ser Leu Ser Thr His Leu Glu Ala Glu Lys Pro
   1               5                  10                  15    
 Leu Arg Arg Tyr Gly Ala Val Glu Glu Thr Ala Trp Lys Thr Glu Arg
              20                  25                  30        
 Leu Gly Arg Asn Gln Leu Asp Ile Ile Ser Met Ala Glu Thr Thr Met
          35                  40                  45            
 Met Pro Glu Glu Ile Glu Leu Glu Met Ala Lys Ile Gln Arg Leu Arg
      50                  55                  60                
 Glu Val Leu Val Arg Arg Glu Ser Glu Leu Arg Phe Met Met Asp Asp
  65                  70                  75                  80
 Ile Gln Leu Cys Lys Asp Ile Met Asp Leu Lys Gln Glu Leu Gln Asn
                  85                  90                  95    
 Leu Val Ala Ile Pro Glu Lys Glu Lys Thr Lys Leu Gln Lys Gln Arg
             100                 105                 110        
 Glu Asp Glu Leu Ile Gln Lys Ile His Lys Leu Val Gln Lys Arg Asp
         115                 120                 125            
 Phe Leu Val Asp Asp Ala Glu Val Glu Arg Leu Arg Glu Gln Glu Glu
     130                 135                 140                
 Asp Lys Glu Met Ala Asp Phe Leu Arg Ile Lys Leu Lys Pro Leu Asp
 145                 150                 155                 160
 Lys Val Thr Lys Ser Pro Ala Ser Ser Arg Ala Glu Lys Lys Ala Glu
                 165                 170                 175    
 Pro Pro Pro Ser Lys Pro Thr Val Ala Lys Thr Gly Leu Ala Leu Ile
             180                 185                 190        
 Lys Asp Cys Cys Gly Ala Thr Gln Cys Asn Ile Met
         195                 200                



      <210> 570
      <211> 512
      <212> PRT
      <213> Homo sapiens


      <400> 570
 Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys Thr Ala Glu Leu Leu
   1               5                  10                  15    
 Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys Asn Phe Val Lys Lys
              20                  25                  30        
 Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu Asp Leu Arg Ser Phe
          35                  40                  45            
 Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln Met Val Met Lys Met
      50                  55                  60                
 Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val Asp Ile Glu Thr Pro
  65                  70                  75                  80
 Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys Glu Phe Leu Val Pro
                  85                  90                  95    
 Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro Gln Ser Pro Gln Gln
             100                 105                 110        
 Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp Arg Tyr Phe Gln Val
         115                 120                 125            
 Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro Asp Arg Gln Pro Glu
     130                 135                 140                
 Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val Asp Gln Thr Gly Ile
 145                 150                 155                 160
 Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser Trp Pro Asn Asp Lys
                 165                 170                 175    
 Asp Pro Val Val Val Pro Phe Pro Thr Met Thr Phe Ala Glu Val Leu
             180                 185                 190        
 Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg Phe Gly Met Lys Ile
         195                 200                 205            
 Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu Ile Gly Phe Leu Gln
     210                 215                 220                
 Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys Ala Ile Cys Ile Pro
 225                 230                 235                 240
 Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile Glu Ser Ile Arg Asn
                 245                 250                 255    
 Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu Pro Val Phe Leu Asn
             260                 265                 270        
 Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn Phe Ile Met Glu Ser
         275                 280                 285            
 Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr Gln Glu Glu Asp Val
     290                 295                 300                
 Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala Cys Ser Leu Leu Gly
 305                 310                 315                 320
 Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Lys Thr Arg Gly Val Val
                 325                 330                 335    
 Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp Val Val Asp Phe Pro
             340                 345                 350        
 Leu Phe Leu Pro Lys Glu Glu Ser Pro Arg Glu Leu Glu Ser Ala His
         355                 360                 365            
 His Pro Phe Thr Ala Pro His Pro Ser Asp Ile His Leu Leu Tyr Thr
     370                 375                 380                
 Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp Leu Val Leu Asn Gly
 385                 390                 395                 400
 Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His Asn Ala Glu Leu Gln
                 405                 410                 415    
 Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp Val Lys Met Leu Ser
             420                 425                 430        
 His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro Pro His Gly Gly Ile
         435                 440                 445            
 Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val Thr Gly Ser Pro Ser
     450                 455                 460                
 Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe Arg Gly His Asp Leu
 465                 470                 475                 480
 Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu Glu Leu Lys Pro Tyr
                 485                 490                 495    
 His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys Ala Glu Arg Ala His
             500                 505                 510        





      <210> 571
      <211> 747
      <212> PRT
      <213> Homo sapiens


      <400> 571
 Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser
   1               5                  10                  15    
 Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro
              20                  25                  30        
 Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro
          35                  40                  45            
 Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala
      50                  55                  60                
 Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu
  65                  70                  75                  80
 Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala
                  85                  90                  95    
 Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg
             100                 105                 110        
 Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu
         115                 120                 125            
 Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp
     130                 135                 140                
 Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys
 145                 150                 155                 160
 Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp
                 165                 170                 175    
 Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu
             180                 185                 190        
 Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu
         195                 200                 205            
 Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val
     210                 215                 220                
 Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile
 225                 230                 235                 240
 Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile
                 245                 250                 255    
 Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp
             260                 265                 270        
 Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro
         275                 280                 285            
 Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys
     290                 295                 300                
 Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln
 305                 310                 315                 320
 Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu
                 325                 330                 335    
 Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln
             340                 345                 350        
 Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr
         355                 360                 365            
 Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg
     370                 375                 380                
 Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala
 385                 390                 395                 400
 Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu
                 405                 410                 415    
 Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu
             420                 425                 430        
 Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val
         435                 440                 445            
 Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile
     450                 455                 460                
 Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly
 465                 470                 475                 480
 Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu
                 485                 490                 495    
 Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu
             500                 505                 510        
 Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro
         515                 520                 525            
 Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr
     530                 535                 540                
 Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala
 545                 550                 555                 560
 Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu
                 565                 570                 575    
 Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala
             580                 585                 590        
 Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly
         595                 600                 605            
 Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp
     610                 615                 620                
 Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn
 625                 630                 635                 640
 Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu
                 645                 650                 655    
 Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly
             660                 665                 670        
 Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro
         675                 680                 685            
 Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp
     690                 695                 700                
 Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp
 705                 710                 715                 720
 Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu
                 725                 730                 735    
 Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser
             740                 745        



      <210> 572
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 572
 Met Ala Leu Asn Asn Val Ser Leu Ser Ser Gly Asp Gln Arg Ser Arg
   1               5                  10                  15    
 Val Ala Tyr Arg Ser Ser His Gly Asp Leu Arg Pro Arg Ala Ser Ala
              20                  25                  30        
 Leu Ala Met Val Ser Gly Asp Gly Phe Leu Val Ser Arg Pro Glu Ala
          35                  40                  45            
 Ile His Leu Gly Pro Arg Gln Ala Val Arg Pro Ser Val Arg Ala Glu
      50                  55                  60                
 Ser Arg Arg Val Asp Gly Gly Gly Arg Ser Pro Arg Glu Pro Asp Gly
  65                  70                  75                  80
 Arg Gly Arg Ser Arg Gln Ala Arg Phe Ser Pro Tyr Pro Ile Pro Ala
                  85                  90                  95    
 Val Glu Pro Asp Leu Leu Arg Ser Val Leu Gln Gln Arg Leu Ile Ala
             100                 105                 110        
 Leu Gly Gly Val Ile Ala Ala Arg Ile Ser Val
         115                 120            



      <210> 573
      <211> 497
      <212> PRT
      <213> Homo sapiens


      <400> 573
 Met Ala Pro Gly Ala Leu Leu Leu Glu Ala Gln Lys Glu Tyr Glu Lys
   1               5                  10                  15    
 Glu Ser Gln Lys Ala Asp Glu Tyr Leu Arg Glu Ile Gln Glu Leu Gly
              20                  25                  30        
 Gln Leu Thr Gln Ala Val Gln Gln Cys Ile Glu Ala Ala Gly His Glu
          35                  40                  45            
 His Gln Pro Asp Met Gln Lys Ser Leu Leu Arg Ala Ala Ser Phe Gly
      50                  55                  60                
 Lys Cys Phe Leu Asp Arg Phe Pro Pro Asp Ser Phe Val His Met Cys
  65                  70                  75                  80
 Gln Asp Leu Arg Val Leu Asn Ala Val Arg Asp Tyr His Ile Gly Ile
                  85                  90                  95    
 Pro Leu Thr Tyr Ser Gln Tyr Lys Gln Leu Thr Ile Gln Val Leu Leu
             100                 105                 110        
 Asp Arg Leu Val Leu Arg Arg Leu Tyr Pro Leu Ala Ile Gln Ile Cys
         115                 120                 125            
 Glu Tyr Leu Arg Leu Pro Glu Val Gln Gly Val Ser Arg Ile Leu Ala
     130                 135                 140                
 His Trp Ala Cys Tyr Lys Val Gln Gln Lys Asp Val Ser Asp Glu Asp
 145                 150                 155                 160
 Val Ala Arg Ala Ile Asn Gln Lys Leu Gly Asp Thr Pro Gly Val Ser
                 165                 170                 175    
 Tyr Ser Asp Ile Ala Ala Arg Ala Tyr Gly Cys Gly Arg Thr Glu Leu
             180                 185                 190        
 Ala Ile Lys Leu Leu Glu Tyr Glu Pro Arg Ser Gly Glu Gln Val Pro
         195                 200                 205            
 Leu Leu Leu Lys Met Lys Arg Ser Lys Leu Ala Leu Ser Lys Ala Ile
     210                 215                 220                
 Glu Ser Gly Asp Thr Asp Leu Val Phe Thr Val Leu Leu His Leu Lys
 225                 230                 235                 240
 Asn Glu Leu Asn Arg Gly Asp Phe Phe Met Thr Leu Arg Asn Gln Pro
                 245                 250                 255    
 Met Ala Leu Ser Leu Tyr Arg Gln Phe Cys Lys His Gln Glu Leu Glu
             260                 265                 270        
 Thr Leu Lys Asp Leu Tyr Asn Gln Asp Asp Asn His Gln Glu Leu Gly
         275                 280                 285            
 Ser Phe His Ile Arg Ala Ser Tyr Ala Ala Glu Glu Arg Ile Glu Gly
     290                 295                 300                
 Arg Val Ala Ala Leu Gln Thr Ala Ala Asp Ala Phe Tyr Lys Ala Lys
 305                 310                 315                 320
 Asn Glu Phe Ala Ala Lys Ala Thr Glu Asp Gln Met Arg Leu Leu Arg
                 325                 330                 335    
 Leu Gln Arg Arg Leu Glu Asp Glu Leu Gly Gly Gln Phe Leu Asp Leu
             340                 345                 350        
 Ser Leu His Asp Thr Val Thr Thr Leu Ile Leu Gly Gly His Asn Lys
         355                 360                 365            
 Arg Ala Glu Gln Leu Ala Arg Asp Phe Arg Ile Pro Asp Lys Arg Leu
     370                 375                 380                
 Trp Trp Leu Lys Leu Thr Ala Leu Ala Asp Leu Glu Asp Trp Glu Glu
 385                 390                 395                 400
 Leu Glu Lys Phe Ser Lys Ser Lys Lys Ser Pro Ile Gly Tyr Leu Pro
                 405                 410                 415    
 Phe Val Glu Ile Cys Met Lys Gln His Asn Lys Tyr Glu Ala Lys Lys
             420                 425                 430        
 Tyr Ala Ser Arg Val Gly Pro Glu Gln Lys Val Lys Ala Leu Leu Leu
         435                 440                 445            
 Val Gly Asp Val Ala Gln Ala Ala Asp Val Ala Ile Glu His Arg Asn
     450                 455                 460                
 Glu Ala Glu Leu Ser Leu Val Leu Ser His Cys Thr Gly Ala Thr Asp
 465                 470                 475                 480
 Gly Ala Thr Ala Asp Lys Ile Gln Arg Ala Arg Ala Gln Ala Gln Lys
                 485                 490                 495    
 Lys
    



      <210> 574
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 574
 Met Asn Gly Gln Leu Asn Gly Phe His Glu Ala Phe Ile Glu Glu Gly
   1               5                  10                  15    
 Thr Phe Leu Phe Thr Ser Glu Ser Val Gly Glu Gly His Pro Asp Lys
              20                  25                  30        
 Ile Cys Asp Gln Ile Ser Asp Ala Val Leu Asp Ala His Leu Gln Gln
          35                  40                  45            
 Asp Pro Asp Ala Lys Val Ala Cys Glu Thr Val Ala Lys Thr Gly Met
      50                  55                  60                
 Ile Leu Leu Ala Gly Glu Ile Thr Ser Arg Ala Ala Val Asp Tyr Gln
  65                  70                  75                  80
 Lys Val Val Arg Glu Ala Val Lys His Ile Gly Tyr Asp Asp Ser Ser
                  85                  90                  95    
 Lys Gly Phe Asp Tyr Lys Thr Cys Asn Val Leu Val Ala Leu Glu Gln
             100                 105                 110        
 Gln Ser Pro Asp Ile Ala Gln Gly Val His Leu Asp Arg Asn Glu Glu
         115                 120                 125            
 Asp Ile Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Thr Asp
     130                 135                 140                
 Glu Thr Glu Glu Cys Met Pro Leu Thr Ile Val Leu Ala His Lys Leu
 145                 150                 155                 160
 Asn Ala Lys Leu Ala Glu Leu Arg Arg Asn Gly Thr Leu Pro Trp Leu
                 165                 170                 175    
 Arg Pro Asp Ser Lys Thr Gln Val Thr Val Gln Tyr Met Gln Asp Arg
             180                 185                 190        
 Gly Ala Val Leu Pro Ile Arg Val His Thr Ile Val Ile Ser Val Gln
         195                 200                 205            
 His Asp Glu Glu Val Cys Leu Asp Glu Met Arg Asp Ala Leu Lys Glu
     210                 215                 220                
 Lys Val Ile Lys Ala Val Val Pro Ala Lys Tyr Leu Asp Glu Asp Thr
 225                 230                 235                 240
 Ile Tyr His Leu Gln Pro Ser Gly Arg Phe Val Ile Gly Trp Ala Ser
                 245                 250                 255    
 Gly Val Met Leu Val
             260    



      <210> 575
      <211> 272
      <212> PRT
      <213> Homo sapiens


      <400> 575
 Met Thr Ser Ser His Val Cys Cys Asn Phe Leu Asn Met Trp Lys Lys
   1               5                  10                  15    
 Ser Lys Ile Ser Thr Met Tyr Tyr Leu Asn Gln Asp Ala Lys Leu Ser
              20                  25                  30        
 Asn Leu Phe Leu Gln Ala Ser Ser Pro Thr Thr Gly Thr Ala Pro Arg
          35                  40                  45            
 Ser Gln Ser Arg Leu Ser Val Cys Pro Ser Thr Gln Asp Ile Cys Arg
      50                  55                  60                
 Ile Cys His Cys Glu Gly Asp Glu Glu Ser Pro Leu Ile Thr Pro Cys
  65                  70                  75                  80
 Arg Cys Thr Gly Thr Leu Arg Phe Val His Gln Ser Cys Leu His Gln
                  85                  90                  95    
 Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr Asp
             100                 105                 110        
 Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys Leu
         115                 120                 125            
 Gln Met Thr Thr Ser Glu Arg Arg Lys Ile Phe Cys Ser Val Thr Phe
     130                 135                 140                
 His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu Ile
 145                 150                 155                 160
 Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Asn Asp Asn Gly Val Leu
                 165                 170                 175    
 Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe Thr
             180                 185                 190        
 Gly Gly Leu Val Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln Leu
         195                 200                 205            
 Trp Arg Arg Leu Lys Ala Tyr Asn Arg Val Ile Phe Val Gln Asn Cys
     210                 215                 220                
 Pro Asp Thr Ala Lys Lys Leu Glu Lys Asn Phe Ser Cys Asn Val Asn
 225                 230                 235                 240
 Thr Asp Ile Lys Asp Ala Val Val Val Pro Val Pro Gln Thr Gly Ala
                 245                 250                 255    
 Asn Ser Leu Pro Ser Ala Glu Gly Gly Pro Pro Glu Val Val Ser Val
             260                 265                 270        





      <210> 576
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 576
 Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala
   1               5                  10                  15    
 Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro
              20                  25                  30        
 Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr
          35                  40                  45            
 Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln
      50                  55                  60                
 Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn
  65                  70                  75                  80
 Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser
                  85                  90                  95    
 Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe
             100                 105                 110        
 Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val
         115                 120                 125            
 Ala Asp Glu Asp Asn Ser Glu Ile Ser Asp Ser Glu Asp Asp Ser Cys
     130                 135                 140                
 Lys
 145



      <210> 577
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 577
 Met Asn Arg Leu Pro Asp Asp Tyr Asp Pro Tyr Ala Val Glu Glu Pro
   1               5                  10                  15    
 Ser Asp Glu Glu Pro Ala Leu Ser Ser Ser Glu Asp Glu Val Asp Val
              20                  25                  30        
 Leu Leu His Gly Thr Pro Asp Gln Lys Arg Lys Leu Ile Arg Glu Cys
          35                  40                  45            
 Leu Thr Gly Glu Ser Glu Ser Ser Ser Glu Asp Glu Phe Glu Lys Glu
      50                  55                  60                
 Met Glu Ala Glu Leu Asn Ser Thr Met Lys Thr Met Glu Asp Lys Leu
  65                  70                  75                  80
 Ser Ser Leu Gly Thr Gly Ser Ser Ser Gly Asn Gly Lys Val Ala Thr
                  85                  90                  95    
 Ala Pro Thr Arg Tyr Tyr Asp Asp Ile Tyr Phe Asp Ser Asp Ser Glu
             100                 105                 110        
 Asp Glu Asp Arg Ala Val Gln Val Thr Lys Lys Lys Lys Lys Lys Gln
         115                 120                 125            
 His Lys Ile Pro Thr Asn Asp Glu Leu Leu Tyr Asp Pro Glu Lys Asp
     130                 135                 140                
 Asn Arg Asp Gln Ala Trp Val Asp Ala Gln Arg Arg Gly Tyr His Gly
 145                 150                 155                 160
 Leu Gly Pro Gln Arg Ser Arg Glu Gln Gln Pro Val Pro Asn Ser Asp
                 165                 170                 175    
 Ala Val Leu Asn Cys Pro Ala Cys Met Thr Thr Leu Cys Leu Asp Cys
             180                 185                 190        
 Gln Arg His Glu Ser Tyr Lys Thr Gln Tyr Arg Ala Met Phe Val Met
         195                 200                 205            
 Asn Cys Ser Ile Asn Lys Glu Glu Val Leu Arg Tyr Lys Ala Ser Glu
     210                 215                 220                
 Asn Arg Lys Lys Arg Arg Val His Lys Lys Met Arg Ser Asn Arg Glu
 225                 230                 235                 240
 Asp Ala Ala Glu Lys Ala Glu Thr Asp Val Glu Glu Ile Tyr His Pro
                 245                 250                 255    
 Val Met Cys Thr Glu Cys Ser Thr Glu Val Ala Val Tyr Asp Lys Asp
             260                 265                 270        
 Glu Val Phe His Phe Phe Asn Val Leu Ala Ser His Ser
         275                 280                 285



      <210> 578
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 578
 Met Ala Ala Ser Arg Leu Pro Pro Ala Thr Leu Thr Leu Lys Gln Phe
   1               5                  10                  15    
 Val Arg Arg Gln Gln Val Leu Leu Leu Tyr Arg Arg Ile Leu Gln Thr
              20                  25                  30        
 Ile Arg Gln Val Pro Asn Asp Ser Asp Arg Lys Tyr Leu Glu Asp Trp
          35                  40                  45            
 Ala Arg Glu Glu Phe Arg Arg Asn Lys Ser Ala Thr Glu Glu Asp Thr
      50                  55                  60                
 Ile Arg Met Met Ile Thr Gln Gly Asn Met Gln Leu Lys Glu Leu Glu
  65                  70                  75                  80
 Lys Thr Leu Ala Leu Ala Lys Ser
                  85            



      <210> 579
      <211> 682
      <212> PRT
      <213> Homo sapiens


      <400> 579
 Met Leu Ser Lys Asp Cys Ser Gln Glu Tyr Thr Asp Ser Thr Gly Ile
   1               5                  10                  15    
 Asp Leu His Glu Phe Leu Ile Asn Thr Leu Lys Asn Asn Ser Arg Asp
              20                  25                  30        
 Arg Met Ile Leu Leu Lys Met Glu Gln Glu Ile Ile Asp Phe Ile Ala
          35                  40                  45            
 Asp Asn Asn Asn His Tyr Lys Lys Phe Pro Gln Met Ser Ser Tyr Gln
      50                  55                  60                
 Arg Met Leu Val His Arg Val Ala Ala Tyr Phe Gly Leu Asp His Asn
  65                  70                  75                  80
 Val Asp Gln Thr Gly Lys Ser Val Ile Ile Asn Lys Thr Ser Ser Thr
                  85                  90                  95    
 Arg Ile Pro Glu Gln Arg Phe Cys Glu His Leu Lys Asp Glu Lys Gly
             100                 105                 110        
 Glu Glu Ser Gln Lys Arg Phe Ile Leu Lys Arg Asp Asn Ser Ser Ile
         115                 120                 125            
 Asp Lys Glu Asp Asn Gln Ser Val Cys Ser Gln Glu Ser Leu Phe Val
     130                 135                 140                
 Glu Asn Ser Arg Leu Leu Glu Asp Ser Asn Ile Cys Asn Glu Thr Tyr
 145                 150                 155                 160
 Lys Lys Arg Gln Leu Phe Arg Gly Asn Arg Asp Gly Ser Gly Arg Thr
                 165                 170                 175    
 Ser Gly Ser Arg Gln Ser Ser Ser Glu Asn Glu Leu Lys Trp Ser Asp
             180                 185                 190        
 His Gln Arg Ala Trp Ser Ser Thr Asp Ser Asp Ser Ser Asn Arg Asn
         195                 200                 205            
 Leu Lys Pro Ala Met Thr Lys Thr Ala Ser Phe Gly Gly Ile Thr Val
     210                 215                 220                
 Leu Thr Arg Gly Asp Ser Thr Ser Ser Thr Arg Ser Thr Gly Lys Leu
 225                 230                 235                 240
 Ser Lys Ala Gly Ser Glu Ser Ser Ser Ser Ala Gly Ser Ser Gly Ser
                 245                 250                 255    
 Leu Ser Arg Thr His Pro Pro Leu Gln Ser Thr Pro Leu Val Ser Gly
             260                 265                 270        
 Val Ala Ala Gly Ser Pro Gly Cys Val Pro Tyr Pro Glu Asn Gly Ile
         275                 280                 285            
 Gly Gly Gln Val Ala Pro Ser Ser Thr Ser Tyr Ile Leu Leu Pro Leu
     290                 295                 300                
 Glu Ala Ala Thr Gly Ile Pro Pro Gly Ser Ile Leu Leu Asn Pro His
 305                 310                 315                 320
 Thr Gly Gln Pro Phe Val Asn Pro Asp Gly Thr Pro Ala Ile Tyr Asn
                 325                 330                 335    
 Pro Pro Thr Ser Gln Gln Pro Leu Arg Ser Ala Met Val Gly Gln Ser
             340                 345                 350        
 Gln Gln Gln Pro Pro Gln Gln Gln Pro Ser Pro Gln Pro Gln Gln Gln
         355                 360                 365            
 Val Gln Pro Pro Gln Pro Gln Met Ala Gly Pro Leu Val Thr Gln Ser
     370                 375                 380                
 Val Gln Gly Leu Gln Ala Ser Ser Gln Ser Val Gln Tyr Pro Ala Val
 385                 390                 395                 400
 Ser Phe Pro Pro Gln His Leu Leu Pro Val Ser Pro Thr Gln His Phe
                 405                 410                 415    
 Pro Met Arg Asp Asp Val Ala Thr Gln Phe Gly Gln Met Thr Leu Ser
             420                 425                 430        
 Arg Gln Ser Ser Gly Glu Thr Pro Glu Pro Pro Ser Gly Pro Val Tyr
         435                 440                 445            
 Pro Ser Ser Leu Met Pro Gln Pro Ala Gln Gln Pro Ser Tyr Val Ile
     450                 455                 460                
 Ala Ser Thr Gly Gln Gln Leu Pro Thr Gly Gly Phe Ser Gly Ser Gly
 465                 470                 475                 480
 Pro Pro Ile Ser Gln Gln Val Leu Gln Pro Pro Pro Ser Pro Gln Gly
                 485                 490                 495    
 Phe Val Gln Gln Pro Pro Pro Ala Gln Met Pro Val Tyr Tyr Tyr Pro
             500                 505                 510        
 Ser Gly Gln Tyr Pro Thr Ser Thr Thr Gln Gln Tyr Arg Pro Met Ala
         515                 520                 525            
 Pro Val Gln Tyr Asn Ala Gln Arg Ser Gln Gln Met Pro Gln Ala Ala
     530                 535                 540                
 Gln Gln Ala Gly Tyr Gln Pro Val Leu Ser Gly Gln Gln Gly Phe Gln
 545                 550                 555                 560
 Gly Leu Ile Gly Val Gln Gln Pro Pro Gln Ser Gln Asn Val Ile Asn
                 565                 570                 575    
 Asn Gln Gln Gly Thr Pro Val Gln Ser Val Met Val Ser Tyr Pro Thr
             580                 585                 590        
 Met Ser Ser Tyr Gln Val Pro Met Thr Gln Gly Ser Gln Gly Leu Pro
         595                 600                 605            
 Gln Gln Ser Tyr Gln Gln Pro Ile Met Leu Pro Asn Gln Ala Gly Gln
     610                 615                 620                
 Gly Ser Leu Pro Ala Thr Gly Met Pro Val Tyr Cys Asn Val Thr Pro
 625                 630                 635                 640
 Pro Thr Pro Gln Asn Asn Leu Arg Leu Ile Gly Pro His Cys Pro Ser
                 645                 650                 655    
 Ser Thr Val Pro Val Met Ser Ala Ser Cys Arg Thr Asn Cys Ala Ser
             660                 665                 670        
 Met Ser Asn Ala Gly Trp Gln Val Lys Phe
         675                 680        



      <210> 580
      <211> 296
      <212> PRT
      <213> Homo sapiens


      <400> 580
 Met Ala Gly Pro Leu Gln Gly Gly Gly Ala Arg Ala Leu Asp Leu Leu
   1               5                  10                  15    
 Arg Gly Leu Pro Arg Val Ser Leu Ala Asn Leu Lys Pro Asn Pro Gly
              20                  25                  30        
 Ser Lys Lys Pro Glu Arg Arg Pro Arg Gly Arg Arg Arg Gly Arg Lys
          35                  40                  45            
 Cys Gly Arg Gly His Lys Gly Glu Arg Gln Arg Gly Thr Arg Pro Arg
      50                  55                  60                
 Leu Gly Phe Glu Gly Gly Gln Thr Pro Phe Tyr Ile Arg Ile Pro Lys
  65                  70                  75                  80
 Tyr Gly Phe Asn Glu Gly His Ser Phe Arg Arg Gln Tyr Lys Pro Leu
                  85                  90                  95    
 Ser Leu Asn Arg Leu Gln Tyr Leu Ile Asp Leu Gly Arg Val Asp Pro
             100                 105                 110        
 Ser Gln Pro Ile Asp Leu Thr Gln Leu Val Asn Gly Arg Gly Val Thr
         115                 120                 125            
 Ile Gln Pro Leu Lys Arg Asp Tyr Gly Val Gln Leu Val Glu Glu Gly
     130                 135                 140                
 Ala Asp Thr Phe Thr Ala Lys Val Asn Ile Glu Val Gln Leu Ala Ser
 145                 150                 155                 160
 Glu Leu Ala Ile Ala Ala Ile Glu Lys Asn Gly Gly Val Val Thr Thr
                 165                 170                 175    
 Ala Phe Tyr Asp Pro Arg Ser Leu Asp Ile Val Cys Lys Pro Val Pro
             180                 185                 190        
 Phe Phe Leu Arg Gly Gln Pro Ile Pro Lys Arg Met Leu Pro Pro Glu
         195                 200                 205            
 Glu Leu Val Pro Tyr Tyr Thr Asp Ala Lys Asn Arg Gly Tyr Leu Ala
     210                 215                 220                
 Asp Pro Ala Lys Phe Pro Glu Ala Arg Leu Glu Leu Ala Arg Lys Tyr
 225                 230                 235                 240
 Gly Tyr Ile Leu Pro Asp Ile Thr Lys Asp Glu Leu Phe Lys Met Leu
                 245                 250                 255    
 Cys Thr Arg Lys Asp Pro Arg Gln Ile Phe Phe Gly Leu Ala Pro Gly
             260                 265                 270        
 Trp Val Val Asn Met Ala Asp Lys Lys Ile Leu Lys Pro Thr Asp Glu
         275                 280                 285            
 Asn Leu Leu Lys Tyr Tyr Thr Ser
     290                 295    



      <210> 581
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 581
 Met Glu Leu Pro Leu Gly Arg Cys Asp Asp Ser Arg Thr Trp Asp Asp
   1               5                  10                  15    
 Asp Ser Asp Pro Glu Ser Glu Thr Asp Pro Asp Ala Gln Ala Lys Ala
              20                  25                  30        
 Tyr Val Ala Arg Val Leu Ser Pro Pro Lys Ser Gly Leu Ala Phe Ser
          35                  40                  45            
 Arg Pro Ser Gln Leu Ser Thr Pro Ala Ala Ser Pro Ser Ala Ser Glu
      50                  55                  60                
 Pro Arg Ala Ala Ser Arg Val Ser Ala Val Ser Glu Pro Gly Leu Leu
  65                  70                  75                  80
 Ser Leu Pro Pro Glu Leu Leu Leu Glu Ile Cys Ser Tyr Leu Asp Ala
                  85                  90                  95    
 Arg Leu Val Leu His Val Leu Ser Arg Val Cys His Ala Leu Arg Asp
             100                 105                 110        
 Leu Val Ser Asp His Val Thr Trp Arg Leu Arg Ala Leu Arg Arg Val
         115                 120                 125            
 Arg Ala Pro Tyr Pro Val Val Glu Glu Lys Asn Phe Asp Trp Pro Ala
     130                 135                 140                
 Ala Cys Ile Ala Leu Glu Gln His Leu Ser Arg Trp Ala Glu Asp Gly
 145                 150                 155                 160
 Arg Trp Val Glu Tyr Phe Cys Leu Ala Glu Gly His Val Ala Ser Val
                 165                 170                 175    
 Asp Ser Val Leu Leu Leu Gln Gly Gly Ser Leu Cys Leu Ser Gly Ser
             180                 185                 190        
 Arg Asp Arg Asn Val Asn Leu Trp Asp Leu Arg Gln Leu Gly Thr Glu
         195                 200                 205            
 Ser Asn Gln Val Leu Ile Lys Thr Leu Gly Thr Lys Arg Asn Ser Thr
     210                 215                 220                
 His Glu Gly Trp Val Trp Ser Leu Ala Ala Gln Asp His Arg Val Cys
 225                 230                 235                 240
 Ser Gly Ser Trp Asp Ser Thr Val Lys Leu Trp Asp Met Ala Ala Asp
                 245                 250                 255    
 Gly Gln Gln Phe Gly Glu Ile Lys Ala Ser Ser Ala Val Leu Cys Leu
             260                 265                 270        
 Ser Tyr Leu Pro Asp Ile Leu Val Thr Gly Thr Tyr Asp Lys Lys Val
         275                 280                 285            
 Thr Ile Tyr Asp Pro Arg Ala Gly Pro Ala Leu Leu Lys His Gln Gln
     290                 295                 300                
 Leu His Ser Arg Pro Val Leu Thr Leu Leu Ala Asp Asp Arg His Ile
 305                 310                 315                 320
 Ile Ser Gly Ser Glu Asp His Thr Leu Val Val Val Asp Arg Arg Ala
                 325                 330                 335    
 Asn Ser Val Leu Gln Arg Leu Gln Leu Asp Ser Tyr Leu Leu Cys Met
             340                 345                 350        
 Ser Tyr Gln Glu Pro Gln Leu Trp Ala Gly Asp Asn Gln Gly Leu Leu
         355                 360                 365            
 His Val Phe Ala Asn Arg Asn Gly Cys Phe Gln Leu Ile Arg Ser Phe
     370                 375                 380                
 Asp Val Gly His Ser Phe Pro Ile Thr Gly Ile Gln Tyr Ser Val Gly
 385                 390                 395                 400
 Ala Leu Tyr Thr Thr Ser Thr Asp Lys Thr Ile Arg Val His Val Pro
                 405                 410                 415    
 Thr Asp Pro Pro Arg Thr Ile Cys Thr Arg Arg His Asp Asn Gly Leu
             420                 425                 430        
 Asn Arg Val Cys Ala Glu Gly Asn Leu Val Val Ala Gly Ser Gly Asp
         435                 440                 445            
 Leu Ser Leu Glu Val Trp Arg Leu Gln Ala
     450                 455            



      <210> 582
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 582
 Met Gly Cys Ala Ser Ala Lys His Val Ala Thr Val Gln Asn Glu Glu
   1               5                  10                  15    
 Glu Ala Gln Lys Gly Lys Asn Tyr Gln Asn Gly Asp Val Phe Gly Asp
              20                  25                  30        
 Glu Tyr Arg Ile Lys Pro Val Glu Glu Val Lys Tyr Met Lys Asn Gly
          35                  40                  45            
 Ala Glu Glu Glu Gln Lys Ile Ala Ala Arg Asn Gln Glu Asn Leu Glu
      50                  55                  60                
 Lys Ser Ala Ser Ser Asn Val Arg Leu Lys Thr Asn Lys Glu Val Pro
  65                  70                  75                  80
 Gly Leu Val His Gln Pro Arg Ala Asn Met His Ile Ser Glu Ser Gln
                  85                  90                  95    
 Gln Glu Phe Phe Arg Met Leu Asp Glu Lys Ile Glu Lys Gly Arg Asp
             100                 105                 110        
 Tyr Cys Ser Glu Glu Glu Asp Ile Thr
         115                 120    



      <210> 583
      <211> 437
      <212> PRT
      <213> Homo sapiens


      <400> 583
 Met Met Met Pro Phe Lys Arg Gln Ala Leu Val Glu Phe Glu Asn Ile
   1               5                  10                  15    
 Asp Ser Ala Lys Glu Cys Val Thr Phe Ala Ala Asp Glu Pro Val Tyr
              20                  25                  30        
 Ile Ala Gly Gln Gln Ala Phe Phe Asn Tyr Ser Thr Ser Lys Arg Ile
          35                  40                  45            
 Thr Arg Pro Gly Asn Thr Asp Asp Pro Ser Gly Gly Asn Lys Val Leu
      50                  55                  60                
 Leu Leu Ser Ile Gln Asn Pro Leu Tyr Pro Ile Thr Val Asp Val Leu
  65                  70                  75                  80
 Tyr Thr Val Cys Asn Pro Val Gly Lys Val Gln Arg Ile Val Ile Phe
                  85                  90                  95    
 Lys Arg Asn Gly Ile Gln Ala Met Val Glu Phe Glu Ser Val Leu Cys
             100                 105                 110        
 Ala Gln Lys Ala Lys Ala Ala Leu Asn Gly Ala Asp Ile Tyr Ala Gly
         115                 120                 125            
 Cys Cys Thr Leu Lys Ile Glu Tyr Ala Arg Pro Thr Arg Leu Asn Val
     130                 135                 140                
 Ile Arg Asn Asp Asn Asp Ser Trp Asp Tyr Thr Lys Pro Tyr Leu Gly
 145                 150                 155                 160
 Arg Arg Asp Arg Gly Lys Gly Arg Gln Arg Gln Ala Ile Leu Gly Glu
                 165                 170                 175    
 His Pro Ser Ser Phe Arg His Asp Gly Tyr Gly Ser His Gly Pro Leu
             180                 185                 190        
 Leu Pro Leu Pro Ser Arg Tyr Arg Met Gly Ser Arg Asp Thr Pro Glu
         195                 200                 205            
 Leu Val Ala Tyr Pro Leu Pro Gln Ala Ser Ser Ser Tyr Met His Gly
     210                 215                 220                
 Gly Asn Pro Ser Gly Ser Val Val Met Val Ser Gly Leu His Gln Leu
 225                 230                 235                 240
 Lys Met Asn Cys Ser Arg Val Phe Asn Leu Phe Cys Leu Tyr Gly Asn
                 245                 250                 255    
 Ile Glu Lys Val Lys Phe Met Lys Thr Ile Pro Gly Thr Ala Leu Val
             260                 265                 270        
 Glu Met Gly Asp Glu Tyr Ala Val Glu Arg Ala Val Thr His Leu Asn
         275                 280                 285            
 Asn Val Lys Leu Phe Gly Lys Arg Leu Asn Val Cys Val Ser Lys Gln
     290                 295                 300                
 His Ser Val Val Pro Ser Gln Ile Phe Glu Leu Glu Asp Gly Thr Ser
 305                 310                 315                 320
 Ser Tyr Lys Asp Phe Ala Met Ser Lys Asn Asn Arg Phe Thr Ser Ala
                 325                 330                 335    
 Gly Gln Ala Ser Lys Asn Ile Ile Gln Pro Pro Ser Cys Val Leu His
             340                 345                 350        
 Tyr Tyr Asn Val Pro Leu Cys Val Thr Glu Glu Thr Phe Thr Lys Leu
         355                 360                 365            
 Cys Asn Asp His Glu Val Leu Thr Phe Ile Lys Tyr Lys Val Phe Asp
     370                 375                 380                
 Ala Lys Pro Ser Ala Lys Thr Leu Ser Gly Leu Leu Glu Trp Glu Cys
 385                 390                 395                 400
 Lys Thr Asp Ala Val Glu Ala Leu Thr Ala Leu Asn His Tyr Gln Ile
                 405                 410                 415    
 Arg Val Pro Asn Gly Ser Asn Pro Tyr Thr Leu Lys Leu Cys Phe Ser
             420                 425                 430        
 Thr Ser Ser His Leu
         435        



      <210> 584
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 584
 Met Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu
   1               5                  10                  15    
 Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu
              20                  25                  30        
 Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val
          35                  40                  45            
 Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp
      50                  55                  60                
 Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser
  65                  70                  75                  80
 Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met
                  85                  90                  95    
 Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val
             100                 105                 110        
 Tyr Phe Ser Thr
         115    



      <210> 585
      <211> 472
      <212> PRT
      <213> Homo sapiens


      <400> 585
 Met Asp Leu Ser Lys Val Val Leu Pro Thr Phe Ile Leu Glu Pro Arg
   1               5                  10                  15    
 Ser Phe Leu Asp Lys Leu Ser Asp Tyr Tyr Tyr His Ala Asp Phe Leu
              20                  25                  30        
 Ser Glu Ala Ala Leu Glu Glu Asn Pro Tyr Phe Arg Leu Lys Lys Val
          35                  40                  45            
 Val Lys Trp Tyr Leu Ser Gly Phe Tyr Lys Lys Pro Lys Gly Leu Lys
      50                  55                  60                
 Lys Pro Tyr Asn Pro Ile Leu Gly Glu Thr Phe Arg Cys Leu Trp Ile
  65                  70                  75                  80
 His Pro Arg Thr Asn Ser Lys Thr Phe Tyr Ile Ala Glu Gln Val Ser
                  85                  90                  95    
 His His Pro Pro Ile Ser Ala Phe Tyr Val Ser Asn Arg Lys Asp Gly
             100                 105                 110        
 Phe Cys Leu Ser Gly Ser Ile Leu Ala Lys Ser Lys Phe Tyr Gly Asn
         115                 120                 125            
 Ser Leu Ser Ala Ile Leu Glu Gly Glu Ala Arg Leu Thr Phe Leu Asn
     130                 135                 140                
 Arg Gly Glu Asp Tyr Val Met Thr Met Pro Tyr Ala His Cys Lys Gly
 145                 150                 155                 160
 Ile Leu Tyr Gly Thr Met Thr Leu Glu Leu Gly Gly Thr Val Asn Ile
                 165                 170                 175    
 Thr Cys Gln Lys Thr Gly Tyr Ser Ala Ile Leu Glu Phe Lys Leu Lys
             180                 185                 190        
 Pro Phe Leu Gly Ser Ser Asp Cys Val Asn Gln Ile Ser Gly Lys Leu
         195                 200                 205            
 Lys Leu Gly Lys Glu Val Leu Ala Thr Leu Glu Gly His Trp Asp Ser
     210                 215                 220                
 Glu Val Phe Ile Thr Asp Lys Lys Thr Asp Asn Ser Glu Val Phe Trp
 225                 230                 235                 240
 Asn Pro Thr Pro Asp Ile Lys Gln Trp Arg Leu Ile Arg His Thr Val
                 245                 250                 255    
 Lys Phe Glu Glu Gln Gly Asp Phe Glu Ser Glu Lys Leu Trp Gln Arg
             260                 265                 270        
 Val Thr Arg Ala Ile Asn Ala Lys Asp Gln Thr Glu Ala Thr Gln Glu
         275                 280                 285            
 Lys Tyr Val Leu Glu Glu Ala Gln Arg Gln Ala Ala Arg Asp Arg Lys
     290                 295                 300                
 Thr Lys Asn Glu Glu Trp Ser Cys Lys Leu Phe Glu Leu Asp Pro Leu
 305                 310                 315                 320
 Thr Gly Glu Trp His Tyr Lys Phe Ala Asp Thr Arg Pro Trp Asp Pro
                 325                 330                 335    
 Leu Asn Asp Met Ile Gln Phe Glu Lys Asp Gly Val Ile Gln Thr Lys
             340                 345                 350        
 Val Lys His Arg Thr Pro Met Val Ser Val Pro Lys Met Lys His Lys
         355                 360                 365            
 Pro Thr Arg Gln Gln Lys Lys Val Ala Lys Gly Tyr Ser Ser Pro Glu
     370                 375                 380                
 Pro Asp Ile Gln Asp Ser Ser Gly Ser Glu Ala Gln Ser Val Lys Pro
 385                 390                 395                 400
 Ser Thr Arg Arg Lys Lys Gly Ile Glu Leu Gly Asp Ile Gln Ser Ser
                 405                 410                 415    
 Ile Glu Ser Ile Lys Gln Thr Gln Glu Glu Lys Lys Lys Asn Ile Met
             420                 425                 430        
 Ala Leu Arg Asn His Leu Val Ser Ser Thr Pro Ala Thr Asp Tyr Phe
         435                 440                 445            
 Leu Gln Gln Lys Asp Tyr Phe Ile Ile Phe Leu Leu Ile Leu Leu Gln
     450                 455                 460                
 Val Ile Ile Asn Phe Met Phe Lys
 465                 470        



      <210> 586
      <211> 491
      <212> PRT
      <213> Homo sapiens


      <400> 586
 Met Ala Gln Ser Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala Val
   1               5                  10                  15    
 Gln Ile Arg Val Ala Ile Gln Glu Ala Glu Asp Val Asp Glu Leu Glu
              20                  25                  30        
 Asp Glu Glu Glu Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala Arg
          35                  40                  45            
 Tyr Leu Ser Pro Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser Arg
      50                  55                  60                
 Gly His Ser Gly Thr Thr Ala Ser Gly Gly Glu Asn Glu Arg Glu Asp
  65                  70                  75                  80
 Leu Glu Gln Glu Trp Lys Pro Pro Asp Glu Glu Leu Ile Lys Lys Leu
                  85                  90                  95    
 Val Asp Gln Ile Glu Phe Tyr Phe Ser Asp Glu Asn Leu Glu Lys Asp
             100                 105                 110        
 Ala Phe Leu Leu Lys His Val Arg Arg Asn Lys Leu Gly Tyr Val Ser
         115                 120                 125            
 Val Lys Leu Leu Thr Ser Phe Lys Lys Val Lys His Leu Thr Arg Asp
     130                 135                 140                
 Trp Arg Thr Thr Ala His Ala Leu Lys Tyr Ser Val Val Leu Glu Leu
 145                 150                 155                 160
 Asn Glu Asp His Arg Lys Val Arg Arg Thr Thr Pro Val Pro Leu Phe
                 165                 170                 175    
 Pro Asn Glu Asn Leu Pro Ser Lys Met Leu Leu Val Tyr Asp Leu Tyr
             180                 185                 190        
 Leu Ser Pro Lys Leu Trp Ala Leu Ala Thr Pro Gln Lys Asn Gly Arg
         195                 200                 205            
 Val Gln Glu Lys Val Met Glu His Leu Leu Lys Leu Phe Gly Thr Phe
     210                 215                 220                
 Gly Val Ile Ser Ser Val Arg Ile Leu Lys Pro Gly Arg Glu Leu Pro
 225                 230                 235                 240
 Pro Asp Ile Arg Arg Ile Ser Ser Arg Tyr Ser Gln Val Gly Thr Gln
                 245                 250                 255    
 Glu Cys Ala Ile Val Glu Phe Glu Glu Val Glu Ala Ala Ile Lys Ala
             260                 265                 270        
 His Glu Phe Met Ile Thr Glu Ser Gln Gly Lys Glu Asn Met Lys Ala
         275                 280                 285            
 Val Leu Ile Gly Met Lys Pro Pro Lys Lys Lys Pro Ala Lys Asp Lys
     290                 295                 300                
 Asn His Asp Glu Glu Pro Thr Ala Ser Ile His Leu Asn Lys Ser Leu
 305                 310                 315                 320
 Asn Lys Arg Val Glu Glu Leu Gln Tyr Met Gly Asp Glu Ser Ser Ala
                 325                 330                 335    
 Asn Ser Ser Ser Asp Pro Glu Ser Asn Pro Thr Ser Pro Met Ala Gly
             340                 345                 350        
 Arg Arg His Ala Ala Thr Asn Lys Leu Ser Pro Ser Gly His Gln Asn
         355                 360                 365            
 Leu Phe Leu Ser Pro Asn Ala Ser Pro Cys Thr Ser Pro Trp Ser Ser
     370                 375                 380                
 Pro Leu Ala Gln Arg Lys Gly Val Ser Arg Lys Ser Pro Leu Ala Glu
 385                 390                 395                 400
 Glu Gly Arg Leu Asn Cys Ser Thr Ser Pro Glu Ile Phe Arg Lys Cys
                 405                 410                 415    
 Met Asp Tyr Ser Ser Asp Ser Ser Val Thr Pro Ser Gly Ser Pro Trp
             420                 425                 430        
 Val Arg Arg Arg Arg Gln Ala Glu Met Gly Thr Gln Glu Lys Ser Pro
         435                 440                 445            
 Gly Thr Ser Pro Leu Leu Ser Arg Lys Met Gln Thr Ala Asp Gly Leu
     450                 455                 460                
 Pro Val Gly Val Leu Arg Leu Pro Arg Gly Pro Asp Asn Thr Arg Gly
 465                 470                 475                 480
 Phe His Gly His Glu Arg Ser Arg Ala Cys Val
                 485                 490    



      <210> 587
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 587
 Met Ala Ala Arg Ser Val Ser Gly Ile Thr Arg Arg Val Phe Met Trp
   1               5                  10                  15    
 Thr Val Ser Gly Thr Pro Cys Arg Glu Phe Trp Ser Arg Phe Arg Lys
              20                  25                  30        
 Glu Lys Glu Pro Val Val Val Glu Thr Val Glu Glu Lys Lys Glu Pro
          35                  40                  45            
 Ile Leu Val Cys Pro Pro Leu Arg Ser Arg Ala Tyr Thr Pro Pro Glu
      50                  55                  60                
 Asp Leu Gln Ser Arg Leu Glu Ser Tyr Val Lys Glu Val Phe Gly Ser
  65                  70                  75                  80
 Ser Leu Pro Ser Asn Trp Gln Asp Ile Ser Leu Glu Asp Ser Arg Leu
                  85                  90                  95    
 Lys Phe Asn Leu Leu Ala His Leu Ala Asp Asp Leu Gly His Val Val
             100                 105                 110        
 Pro Asn Ser Arg Leu His Gln Met Cys Arg Val Arg Asp Val Leu Asp
         115                 120                 125            
 Phe Tyr Asn Val Pro Ile Gln Asp Arg Ser Lys Phe Asp Glu Leu Ser
     130                 135                 140                
 Ala Ser Asn Leu Pro Pro Asn Leu Lys Ile Thr Trp Ser Tyr
 145                 150                 155            



      <210> 588
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 588
 Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg
   1               5                  10                  15    
 Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg
              20                  25                  30        
 Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val
          35                  40                  45            
 Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys
      50                  55                  60                
 Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile
  65                  70                  75                  80
 Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys
                  85                  90                  95    
 Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu
             100                 105                 110        
 Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr
         115                 120                 125            
 Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe
     130                 135                 140                
 Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu
 145                 150                 155                 160
 Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile
                 165                 170                 175    
 Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro
             180                 185                 190        
 Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu
         195                 200                 205            
 Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro
     210                 215                 220                
 Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly
 225                 230                 235                 240
 Asp Thr Trp Asp Glu
                 245



      <210> 589
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 589
 Met Gly Asn Cys Val Lys Tyr Pro Leu Arg Asn Leu Ser Arg Lys Met
   1               5                  10                  15    
 Arg Gln Glu Glu Gln Thr Ser Tyr Met Val Val Gln Thr Thr Glu Glu
              20                  25                  30        
 Gly Leu Ala Ala Asp Ala Glu Leu Pro Gly Pro Leu Leu Met Leu Ala
          35                  40                  45            
 Gln Asn Cys Ala Val Met His Asn Leu Leu Gly Pro Ala Cys Ile Phe
      50                  55                  60                
 Leu Arg Lys Gly Phe Ala Glu Asn Arg Gln Pro Asp Arg Ser Leu Arg
  65                  70                  75                  80
 Pro Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg Glu Phe Asp Lys
                  85                  90                  95    
 Asp Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly Asn Cys Met Arg
             100                 105                 110        
 Thr Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu Leu Ser Gln
         115                 120                 125            
 Gln Ile Asn Met Asn Leu Gly Gly His Val Asp Phe Asp Asp Phe Val
     130                 135                 140                
 Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp Met Ile Gly
 145                 150                 155                 160
 Val Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr Asn Gly Asp
                 165                 170                 175    
 Gly Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met Arg Lys Leu Leu
             180                 185                 190        
 Gly His Gln Val Gly His Arg Asp Ile Glu Glu Ile Ile Arg Asp Val
         195                 200                 205            
 Asp Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu Phe Val Arg Met
     210                 215                 220                
 Met Ser Arg
 225        



      <210> 590
      <211> 789
      <212> PRT
      <213> Homo sapiens


      <400> 590
 Met Arg Lys Val Glu Ser Arg Gly Glu Gly Gly Arg Glu Glu Leu Gly
   1               5                  10                  15    
 Ser Asn Ser Pro Pro Gln Arg Asn Trp Lys Gly Ile Ala Ile Ala Leu
              20                  25                  30        
 Leu Val Ile Leu Val Val Cys Ser Leu Ile Thr Met Ser Val Ile Leu
          35                  40                  45            
 Leu Thr Pro Asp Glu Leu Thr Asn Ser Ser Glu Thr Arg Leu Ser Leu
      50                  55                  60                
 Glu Asp Leu Phe Arg Lys Asp Phe Val Leu His Asp Pro Glu Ala Arg
  65                  70                  75                  80
 Trp Ile Asn Asp Thr Asp Val Val Tyr Lys Ser Glu Asn Gly His Val
                  85                  90                  95    
 Ile Lys Leu Asn Ile Glu Thr Asn Ala Thr Thr Leu Leu Leu Glu Asn
             100                 105                 110        
 Thr Thr Phe Val Thr Phe Lys Ala Ser Arg His Ser Val Ser Pro Asp
         115                 120                 125            
 Leu Lys Tyr Val Leu Leu Ala Tyr Asp Val Lys Gln Ile Phe His Tyr
     130                 135                 140                
 Ser Tyr Thr Ala Ser Tyr Val Ile Tyr Asn Ile His Thr Arg Glu Val
 145                 150                 155                 160
 Trp Glu Leu Asn Pro Pro Glu Val Glu Asp Ser Val Leu Gln Tyr Ala
                 165                 170                 175    
 Ala Trp Gly Val Gln Gly Gln Gln Leu Ile Tyr Ile Phe Glu Asn Asn
             180                 185                 190        
 Ile Tyr Tyr Gln Pro Asp Ile Lys Ser Ser Ser Leu Arg Leu Thr Ser
         195                 200                 205            
 Ser Gly Lys Glu Glu Ile Ile Phe Asn Gly Ile Ala Asp Trp Leu Tyr
     210                 215                 220                
 Glu Glu Glu Leu Leu His Ser His Ile Ala His Trp Trp Ser Pro Asp
 225                 230                 235                 240
 Gly Glu Arg Leu Ala Phe Leu Met Ile Asn Asp Ser Leu Val Pro Thr
                 245                 250                 255    
 Met Val Ile Pro Arg Phe Thr Gly Ala Leu Tyr Pro Lys Gly Lys Gln
             260                 265                 270        
 Tyr Pro Tyr Pro Lys Ala Gly Gln Val Asn Pro Thr Ile Lys Leu Tyr
         275                 280                 285            
 Val Val Asn Leu Tyr Gly Pro Thr His Thr Leu Glu Leu Met Pro Pro
     290                 295                 300                
 Asp Ser Phe Lys Ser Arg Glu Tyr Tyr Ile Thr Met Val Lys Trp Val
 305                 310                 315                 320
 Ser Asn Thr Lys Thr Val Val Arg Trp Leu Asn Arg Ala Gln Asn Ile
                 325                 330                 335    
 Ser Ile Leu Thr Val Cys Glu Thr Thr Thr Gly Ala Cys Ser Lys Lys
             340                 345                 350        
 Tyr Glu Met Thr Ser Asp Thr Trp Leu Ser Gln Arg Asn Glu Glu Pro
         355                 360                 365            
 Val Phe Ser Arg Asp Gly Ser Lys Phe Phe Met Thr Val Pro Val Lys
     370                 375                 380                
 Gln Gly Gly Arg Gly Glu Phe His His Ile Ala Met Phe Leu Ile Gln
 385                 390                 395                 400
 Ser Lys Ser Glu Gln Ile Thr Val Arg His Leu Thr Ser Gly Asn Trp
                 405                 410                 415    
 Glu Val Ile Lys Ile Leu Ala Tyr Asp Glu Thr Thr Gln Lys Ile Tyr
             420                 425                 430        
 Phe Leu Ser Thr Glu Ser Ser Pro Arg Gly Arg Gln Leu Tyr Ser Ala
         435                 440                 445            
 Ser Thr Glu Gly Leu Leu Asn Arg Gln Cys Ile Ser Cys Asn Phe Met
     450                 455                 460                
 Lys Glu Gln Cys Thr Tyr Phe Asp Ala Ser Phe Ser Pro Met Asn Gln
 465                 470                 475                 480
 His Phe Leu Leu Phe Cys Glu Gly Pro Arg Val Pro Val Val Ser Leu
                 485                 490                 495    
 His Ser Thr Asp Asn Pro Ala Lys Tyr Phe Ile Leu Glu Ser Asn Ser
             500                 505                 510        
 Met Leu Lys Glu Ala Ile Leu Lys Lys Lys Ile Gly Lys Pro Glu Ile
         515                 520                 525            
 Lys Ile Leu His Ile Asp Asp Tyr Glu Leu Pro Leu Gln Leu Ser Leu
     530                 535                 540                
 Pro Lys Asp Phe Met Asp Arg Asn Gln Tyr Ala Leu Leu Leu Ile Met
 545                 550                 555                 560
 Asp Glu Glu Pro Gly Gly Gln Leu Val Thr Asp Lys Phe His Ile Asp
                 565                 570                 575    
 Trp Asp Ser Val Leu Ile Asp Met Asp Asn Val Ile Val Ala Arg Phe
             580                 585                 590        
 Asp Gly Arg Gly Ser Gly Phe Gln Gly Leu Lys Ile Leu Gln Glu Ile
         595                 600                 605            
 His Arg Arg Leu Gly Ser Val Glu Val Lys Asp Gln Ile Thr Ala Val
     610                 615                 620                
 Lys Phe Leu Leu Lys Leu Pro Tyr Ile Asp Ser Lys Arg Leu Ser Ile
 625                 630                 635                 640
 Phe Gly Lys Gly Tyr Gly Gly Tyr Ile Ala Ser Met Ile Leu Lys Ser
                 645                 650                 655    
 Asp Glu Lys Leu Phe Lys Cys Gly Ser Val Val Ala Pro Ile Thr Asp
             660                 665                 670        
 Leu Lys Leu Tyr Ala Ser Ala Phe Ser Glu Arg Tyr Leu Gly Met Pro
         675                 680                 685            
 Ser Lys Glu Glu Ser Thr Tyr Gln Ala Ala Ser Val Leu His Asn Val
     690                 695                 700                
 His Gly Leu Lys Glu Glu Asn Ile Leu Ile Ile His Gly Thr Ala Asp
 705                 710                 715                 720
 Thr Lys Val His Phe Gln His Ser Ala Glu Leu Ile Lys His Leu Ile
                 725                 730                 735    
 Lys Ala Gly Val Asn Tyr Thr Met Gln Val Tyr Pro Asp Glu Gly His
             740                 745                 750        
 Asn Val Ser Glu Lys Ser Lys Tyr His Leu Tyr Ser Thr Ile Leu Lys
         755                 760                 765            
 Phe Phe Ser Asp Cys Leu Lys Glu Glu Ile Ser Val Leu Pro Gln Glu
     770                 775                 780                
 Pro Glu Glu Asp Glu
 785                



      <210> 591
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 591
 Met Ala Gly Leu Leu Ala Leu Leu Gly Pro Ala Gly Arg Val Gly Ala
   1               5                  10                  15    
 Arg Val Arg Pro Arg Ala Thr Trp Leu Leu Gly Ala Thr Ala Pro Cys
              20                  25                  30        
 Ala Pro Pro Pro Leu Ala Leu Ala Leu Leu Pro Pro Arg Leu Asp Ala
          35                  40                  45            
 Arg Leu Leu Arg Thr Ala Arg Gly Asp Cys Arg Gly His Gln Asp Pro
      50                  55                  60                
 Ser Gln Ala Thr Gly Thr Thr Gly Ser Ser Val Ser Cys Thr Glu Glu
  65                  70                  75                  80
 Lys Lys Gln Ser Lys Ser Gln Gln Leu Lys Lys Ile Phe Gln Glu Tyr
                  85                  90                  95    
 Gly Thr Val Gly Val Ser Leu His Ile Gly Ile Ser Leu Ile Ser Leu
             100                 105                 110        
 Gly Ile Phe Tyr Met Val Val Ser Ser Gly Val Asp Met Pro Ala Ile
         115                 120                 125            
 Leu Leu Lys Leu Gly Phe Lys Glu Ser Leu Val Gln Ser Lys Met Ala
     130                 135                 140                
 Ala Gly Thr Ser Thr Phe Val Val Ala Tyr Ala Ile His Lys Leu Phe
 145                 150                 155                 160
 Ala Pro Val Arg Ile Ser Ile Thr Leu Val Ser Val Pro Leu Ile Val
                 165                 170                 175    
 Arg Tyr Phe Arg Lys Val Gly Phe Phe Lys Pro Pro Ala Ala Lys Pro
             180                 185                 190        





      <210> 592
      <211> 444
      <212> PRT
      <213> Homo sapiens


      <400> 592
 Met Ser Glu Glu Thr Ala Thr Ser Asp Asn Asp Asn Ser Tyr Ala Arg
   1               5                  10                  15    
 Val Arg Ala Val Val Met Thr Arg Asp Asp Ser Ser Gly Gly Trp Leu
              20                  25                  30        
 Pro Leu Gly Gly Ser Gly Leu Ser Ser Val Thr Val Phe Lys Val Pro
          35                  40                  45            
 His Gln Glu Glu Asn Gly Cys Ala Asp Phe Phe Ile Arg Gly Glu Arg
      50                  55                  60                
 Leu Arg Asp Lys Met Val Val Leu Glu Cys Met Leu Lys Lys Asp Leu
  65                  70                  75                  80
 Ile Tyr Asn Lys Val Thr Pro Thr Phe His His Trp Lys Ile Asp Asp
                  85                  90                  95    
 Lys Lys Phe Gly Leu Thr Phe Gln Ser Pro Ala Asp Ala Arg Ala Phe
             100                 105                 110        
 Asp Arg Gly Ile Arg Arg Ala Ile Glu Asp Ile Ser Gln Gly Cys Pro
         115                 120                 125            
 Glu Ser Lys Asn Glu Ala Glu Gly Ala Asp Asp Leu Gln Ala Asn Glu
     130                 135                 140                
 Glu Asp Ser Ser Ser Ser Leu Val Lys Asp His Leu Phe Gln Gln Glu
 145                 150                 155                 160
 Thr Val Val Thr Ser Glu Pro Tyr Arg Ser Ser Asn Ile Arg Pro Ser
                 165                 170                 175    
 Pro Phe Glu Asp Leu Asn Ala Arg Arg Val Tyr Met Gln Ser Gln Ala
             180                 185                 190        
 Asn Gln Ile Thr Phe Gly Gln Pro Gly Leu Asp Ile Gln Ser Arg Ser
         195                 200                 205            
 Met Glu Tyr Val Gln Arg Gln Ile Ser Lys Glu Cys Gly Ser Leu Lys
     210                 215                 220                
 Ser Gln Asn Arg Val Pro Leu Lys Ser Ile Arg His Val Ser Phe Gln
 225                 230                 235                 240
 Asp Glu Asp Glu Ile Val Arg Ile Asn Pro Arg Asp Ile Leu Ile Arg
                 245                 250                 255    
 Arg Tyr Ala Asp Tyr Arg His Pro Asp Met Trp Lys Asn Asp Leu Glu
             260                 265                 270        
 Arg Asp Asp Ala Asp Ser Ser Ile Gln Phe Ser Lys Pro Asp Ser Lys
         275                 280                 285            
 Lys Ser Asp Tyr Leu Tyr Ser Cys Gly Asp Glu Thr Lys Leu Ser Ser
     290                 295                 300                
 Pro Lys Asp Ser Val Val Phe Lys Thr Gln Pro Ser Ser Leu Lys Ile
 305                 310                 315                 320
 Lys Lys Ser Lys Arg Arg Lys Glu Asp Gly Glu Arg Ser Arg Cys Val
                 325                 330                 335    
 Tyr Cys Gln Glu Arg Phe Asn His Glu Glu Asn Val Arg Gly Lys Cys
             340                 345                 350        
 Gln Asp Ala Pro Asp Pro Ile Lys Arg Cys Ile Tyr Gln Val Ser Cys
         355                 360                 365            
 Met Leu Cys Ala Glu Ser Met Leu Tyr His Cys Met Ser Asp Ser Glu
     370                 375                 380                
 Gly Asp Phe Ser Asp Pro Cys Ser Cys Asp Thr Ser Asp Asp Lys Phe
 385                 390                 395                 400
 Cys Leu Arg Trp Leu Ala Leu Val Ala Leu Ser Phe Ile Val Pro Cys
                 405                 410                 415    
 Met Cys Trp Tyr Val Pro Leu Arg Met Cys His Arg Cys Gly Glu Ala
             420                 425                 430        
 Cys Gly Cys Cys Gly Gly Lys His Lys Ala Ala Gly
         435                 440                



      <210> 593
      <211> 573
      <212> PRT
      <213> Homo sapiens


      <400> 593
 Met Leu Ser Ala Pro Cys Cys Asp Asp Arg Arg Met Cys Val Cys Pro
   1               5                  10                  15    
 Gly Pro Arg Arg Ile Gly Ile Pro Val Arg Ser Ser Ser Leu Pro Leu
              20                  25                  30        
 Phe Ser Asp Ala Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Ile
          35                  40                  45            
 Arg Asn Cys Glu Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His
      50                  55                  60                
 His Lys His Leu Cys Cys Ser Ser Ser Tyr Ile Pro Gln Ser Arg Leu
  65                  70                  75                  80
 Arg Tyr Thr Pro His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Lys Glu
                  85                  90                  95    
 Asn Trp Trp Gln Tyr Thr Gln Gly Arg Arg Tyr Ala Ser Thr Pro Gln
             100                 105                 110        
 Lys Phe Tyr Leu Thr Pro Pro Gln Val Asn Ser Ile Leu Lys Ala Asn
         115                 120                 125            
 Glu Tyr Ser Phe Lys Val Pro Glu Phe Asp Gly Lys Met Ser Val Leu
     130                 135                 140                
 Ser Leu Asp Leu Thr Ala Ile Lys Leu Pro Ala Asn Ala Pro Ile Glu
 145                 150                 155                 160
 Asp Arg Arg Ser Ala Ala Thr Cys Leu Gln Thr Arg Gly Met Leu Leu
                 165                 170                 175    
 Gly Val Phe Asp Gly His Ala Gly Cys Ala Trp Ser Gln Ala Val Ser
             180                 185                 190        
 Glu Arg Leu Phe Tyr Tyr Ile Ala Gly Ser Leu Val Pro His Glu Thr
         195                 200                 205            
 Leu Leu Glu Ile Glu Asn Ala Val Glu Ser Gly Arg Ala Leu Leu Pro
     210                 215                 220                
 Ile Leu Gln Trp His Lys His Pro Asn Asp Tyr Phe Ser Lys Glu Ala
 225                 230                 235                 240
 Ser Lys Leu Tyr Phe Asn Ser Leu Arg Thr Tyr Trp Gln Glu Leu Ile
                 245                 250                 255    
 Asp Leu Asn Thr Gly Glu Ser Thr Asp Ile Asp Val Lys Glu Ala Leu
             260                 265                 270        
 Ile Asn Ala Phe Lys Arg Leu Asp Asn Asp Ile Ser Leu Glu Ala Gln
         275                 280                 285            
 Val Gly Asp Pro Asn Ser Phe Leu Asn Tyr Leu Val Leu Arg Val Ala
     290                 295                 300                
 Phe Ser Gly Ala Thr Ala Cys Val Ala His Val Asp Gly Val Asp Leu
 305                 310                 315                 320
 His Val Ala Asn Thr Gly Asp Ser Arg Ala Met Leu Gly Val Gln Glu
                 325                 330                 335    
 Glu Asp Gly Ser Trp Ser Ala Val Thr Leu Ser Asn Asp His Asn Ala
             340                 345                 350        
 Gln Asn Glu Arg Glu Leu Glu Arg Leu Lys Leu Glu His Pro Lys Ser
         355                 360                 365            
 Glu Ala Lys Ser Val Val Lys Gln Asp Arg Leu Leu Gly Leu Leu Met
     370                 375                 380                
 Pro Phe Arg Ala Phe Gly Asp Val Lys Phe Lys Trp Ser Ile Asp Leu
 385                 390                 395                 400
 Gln Lys Arg Val Ile Glu Ser Gly Pro Asp Gln Leu Asn Asp Asn Glu
                 405                 410                 415    
 Tyr Thr Lys Phe Ile Pro Pro Asn Tyr His Thr Pro Pro Tyr Leu Thr
             420                 425                 430        
 Ala Glu Pro Glu Val Thr Tyr His Arg Leu Arg Pro Gln Asp Lys Phe
         435                 440                 445            
 Leu Val Leu Ala Thr Asp Gly Leu Trp Glu Thr Met His Arg Gln Asp
     450                 455                 460                
 Val Val Arg Ile Val Gly Glu Tyr Leu Thr Gly Met His His Gln Gln
 465                 470                 475                 480
 Pro Ile Ala Val Gly Gly Tyr Lys Val Thr Leu Gly Gln Met His Gly
                 485                 490                 495    
 Leu Leu Thr Glu Arg Arg Thr Lys Met Ser Ser Val Phe Glu Asp Gln
             500                 505                 510        
 Asn Ala Ala Thr His Leu Ile Arg His Ala Val Gly Asn Asn Glu Phe
         515                 520                 525            
 Gly Thr Val Asp His Glu Arg Leu Ser Lys Met Leu Ser Leu Pro Glu
     530                 535                 540                
 Glu Leu Ala Arg Met Tyr Arg Asp Asp Ile Thr Ile Ile Val Val Gln
 545                 550                 555                 560
 Phe Asn Ser His Val Val Gly Ala Tyr Gln Asn Gln Glu
                 565                 570            



      <210> 594
      <211> 273
      <212> PRT
      <213> Homo sapiens


      <400> 594
 Met Arg Thr Arg Cys Ala Pro Gly Thr Gly Val Gly Gly Arg Pro Gly
   1               5                  10                  15    
 Gly Asp Gly Gln Glu Val Arg Ser Lys His Pro Thr Pro Leu Trp Asn
              20                  25                  30        
 Leu Ser Asp Phe Tyr Leu Ser Phe Cys Asn Ser Tyr Thr Leu Trp Glu
          35                  40                  45            
 Leu Phe Ser Gly Leu Ser Ser Pro Asn Thr Leu Asn Cys Ser Leu Asp
      50                  55                  60                
 Val Val Leu Lys Glu Gly Gly Glu Met Thr Thr Cys Arg Gln Cys Val
  65                  70                  75                  80
 Glu Ala Tyr Gln Asp Tyr Asp His His Ala Gln Glu Lys Tyr Glu Glu
                  85                  90                  95    
 Phe Glu Ser Val Leu His Lys Tyr Leu Gln Ser Glu Glu Tyr Ser Val
             100                 105                 110        
 Lys Ser Cys Pro Glu Asp Cys Lys Ile Val Tyr Lys Ala Trp Leu Cys
         115                 120                 125            
 Ser Gln Tyr Phe Glu Val Thr Gln Phe Asn Cys Arg Lys Thr Ile Pro
     130                 135                 140                
 Cys Lys Gln Tyr Cys Leu Glu Val Gln Thr Arg Cys Pro Phe Ile Leu
 145                 150                 155                 160
 Pro Asp Asn Asp Glu Val Ile Tyr Gly Gly Leu Ser Ser Phe Ile Cys
                 165                 170                 175    
 Thr Gly Leu Tyr Glu Thr Phe Leu Thr Asn Asp Glu Pro Glu Cys Cys
             180                 185                 190        
 Asp Val Arg Arg Glu Glu Lys Ser Asn Asn Pro Ser Lys Gly Thr Val
         195                 200                 205            
 Glu Lys Ser Gly Ser Cys His Arg Thr Ser Leu Thr Val Ser Ser Ala
     210                 215                 220                
 Thr Arg Leu Cys Asn Ser Arg Leu Lys Leu Cys Val Leu Val Leu Ile
 225                 230                 235                 240
 Leu Leu His Thr Val Leu Thr Ala Ser Ala Ala Gln Asn Thr Ala Gly
                 245                 250                 255    
 Leu Ser Phe Gly Gly Ile Asn Thr Leu Glu Glu Asn Ser Thr Asn Glu
             260                 265                 270        
 Glu
    



      <210> 595
      <211> 370
      <212> PRT
      <213> Homo sapiens


      <400> 595
 Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Thr Cys His Ala Trp
   1               5                  10                  15    
 Asn Arg Asp Arg Thr Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val
              20                  25                  30        
 His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu
          35                  40                  45            
 Lys Glu His Asn Gly His Ile Thr Gly Ile Asp Trp Ala Pro Lys Ser
      50                  55                  60                
 Asp Arg Ile Val Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser
  65                  70                  75                  80
 Gln Lys Asp Gly Val Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn
                  85                  90                  95    
 Arg Ala Ala Thr Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala
             100                 105                 110        
 Val Gly Ser Gly Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu Ser Glu
         115                 120                 125            
 Asn Asp Trp Trp Val Ser Lys His Ile Lys Lys Pro Ile Arg Ser Thr
     130                 135                 140                
 Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly
 145                 150                 155                 160
 Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys Glu Val
                 165                 170                 175    
 Asp Glu Lys Pro Ala Ser Thr Pro Trp Gly Ser Lys Met Pro Phe Gly
             180                 185                 190        
 Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Thr Gly Gly Trp Val His
         195                 200                 205            
 Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val Ser His
     210                 215                 220                
 Asp Ser Thr Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln Val Ser
 225                 230                 235                 240
 Thr Leu Lys Thr Glu Phe Leu Pro Leu Leu Ser Val Ser Phe Val Ser
                 245                 250                 255    
 Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys Pro Met Leu Phe
             260                 265                 270        
 Asn Tyr Asp Asp Arg Gly Cys Leu Thr Phe Val Ser Lys Leu Asp Ile
         275                 280                 285            
 Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met Glu Arg Phe Arg
     290                 295                 300                
 Asn Met Asp Lys Arg Ala Thr Thr Glu Asp Arg Asn Thr Ala Leu Glu
 305                 310                 315                 320
 Thr Leu His Gln Asn Ser Ile Thr Gln Val Ser Ile Tyr Glu Val Asp
                 325                 330                 335    
 Lys Gln Asp Cys Arg Lys Phe Cys Thr Thr Gly Ile Asp Gly Ala Met
             340                 345                 350        
 Thr Ile Trp Asp Phe Lys Thr Leu Glu Ser Ser Ile Gln Gly Leu Arg
         355                 360                 365            
 Ile Met
     370



      <210> 596
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 596
 Met Ser Gly Lys Ser Leu Leu Leu Lys Val Ile Leu Leu Gly Asp Gly
   1               5                  10                  15    
 Gly Val Gly Lys Ser Ser Leu Met Asn Arg Tyr Val Thr Asn Lys Phe
              20                  25                  30        
 Asp Ser Gln Ala Phe His Thr Ile Gly Val Glu Phe Leu Asn Arg Asp
          35                  40                  45            
 Leu Glu Val Asp Gly Arg Phe Val Thr Leu Gln Ile Trp Asp Thr Ala
      50                  55                  60                
 Gly Gln Glu Arg Phe Lys Ser Leu Arg Thr Pro Phe Tyr Arg Gly Ala
  65                  70                  75                  80
 Asp Cys Cys Leu Leu Thr Phe Ser Val Asp Asp Arg Gln Ser Phe Glu
                  85                  90                  95    
 Asn Leu Gly Asn Trp Gln Lys Glu Phe Ile Tyr Tyr Ala Asp Val Lys
             100                 105                 110        
 Asp Pro Glu His Phe Pro Phe Val Val Leu Gly Asn Lys Val Asp Lys
         115                 120                 125            
 Glu Asp Arg Gln Val Thr Thr Glu Glu Ala Gln Thr Trp Cys Met Glu
     130                 135                 140                
 Asn Gly Asp Tyr Pro Tyr Leu Glu Thr Ser Ala Lys Asp Asp Thr Asn
 145                 150                 155                 160
 Val Thr Val Ala Phe Glu Glu Ala Val Arg Gln Val Leu Ala Val Glu
                 165                 170                 175    
 Glu Gln Leu Glu His Cys Met Leu Gly His Thr Ile Asp Leu Asn Ser
             180                 185                 190        
 Gly Ser Lys Ala Gly Ser Ser Cys Cys
         195                 200    



      <210> 597
      <211> 1402
      <212> PRT
      <213> Homo sapiens


      <400> 597
 Met His Phe Arg Ala Arg Ala Thr Gly Pro Ala Ala Pro Pro Pro Arg
   1               5                  10                  15    
 Leu Arg Glu Val His Asp Ser Tyr Ala Leu Leu Val Ala Glu Ser Trp
              20                  25                  30        
 Arg Glu Thr Val Gln Leu Tyr Glu Asp Glu Val Arg Glu Leu Glu Glu
          35                  40                  45            
 Ala Leu Arg Arg Gly Gln Glu Ser Arg Leu Gln Ala Glu Glu Glu Thr
      50                  55                  60                
 Arg Leu Cys Ala Gln Glu Ala Glu Ala Leu Arg Arg Glu Ala Leu Gly
  65                  70                  75                  80
 Leu Glu Gln Leu Arg Ala Arg Leu Glu Asp Ala Leu Leu Arg Met Arg
                  85                  90                  95    
 Glu Glu Tyr Gly Ile Gln Ala Glu Glu Arg Gln Arg Ala Ile Asp Cys
             100                 105                 110        
 Leu Glu Asp Glu Lys Ala Thr Leu Thr Leu Ala Met Ala Asp Trp Leu
         115                 120                 125            
 Arg Asp Tyr Gln Asp Leu Leu Gln Val Lys Thr Gly Leu Ser Leu Glu
     130                 135                 140                
 Val Ala Thr Tyr Arg Ala Leu Leu Glu Gly Glu Ser Asn Pro Glu Ile
 145                 150                 155                 160
 Val Ile Trp Ala Glu His Val Glu Asn Met Pro Ser Glu Phe Arg Asn
                 165                 170                 175    
 Lys Ser Tyr His Tyr Thr Asp Ser Leu Leu Gln Arg Glu Asn Glu Trp
             180                 185                 190        
 Asn Leu Phe Ser Arg Gln Lys Ala Pro Leu Ala Ser Phe Asn His Ser
         195                 200                 205            
 Ser Ala Leu Tyr Ser Asn Leu Ser Gly His Arg Gly Ser Gln Thr Gly
     210                 215                 220                
 Thr Ser Ile Gly Gly Asp Ala Arg Arg Gly Phe Leu Gly Ser Gly Tyr
 225                 230                 235                 240
 Ser Ser Ser Ala Thr Thr Gln Gln Glu Asn Ser Tyr Gly Lys Ala Val
                 245                 250                 255    
 Ser Ser Gln Thr Asn Val Arg Thr Phe Ser Pro Thr Tyr Gly Leu Leu
             260                 265                 270        
 Arg Asn Thr Glu Ala Gln Val Lys Thr Phe Pro Asp Arg Pro Lys Ala
         275                 280                 285            
 Gly Asp Thr Arg Glu Val Pro Val Tyr Ile Gly Glu Asp Ser Thr Ile
     290                 295                 300                
 Ala Arg Glu Ser Tyr Arg Asp Arg Arg Asp Lys Val Ala Ala Gly Ala
 305                 310                 315                 320
 Ser Glu Ser Thr Arg Ser Asn Glu Arg Thr Val Ile Leu Gly Lys Lys
                 325                 330                 335    
 Thr Glu Val Lys Ala Thr Arg Glu Gln Glu Arg Asn Arg Pro Glu Thr
             340                 345                 350        
 Ile Arg Thr Lys Pro Glu Glu Lys Met Phe Asp Ser Lys Glu Lys Ala
         355                 360                 365            
 Ser Glu Glu Arg Asn Leu Arg Trp Glu Glu Leu Thr Lys Leu Asp Lys
     370                 375                 380                
 Glu Ala Arg Gln Arg Glu Ser Gln Gln Met Lys Glu Lys Ala Lys Glu
 385                 390                 395                 400
 Lys Asp Ser Pro Lys Glu Lys Ser Val Arg Glu Arg Glu Val Pro Ile
                 405                 410                 415    
 Ser Leu Glu Val Ser Gln Asp Arg Arg Ala Glu Val Ser Pro Lys Gly
             420                 425                 430        
 Leu Gln Thr Pro Val Lys Asp Ala Gly Gly Gly Thr Gly Arg Glu Ala
         435                 440                 445            
 Glu Ala Arg Glu Leu Arg Phe Arg Leu Gly Thr Ser Asp Ala Thr Gly
     450                 455                 460                
 Ser Leu Gln Gly Asp Ser Met Thr Glu Thr Val Ala Glu Asn Ile Val
 465                 470                 475                 480
 Thr Ser Ile Leu Lys Gln Phe Thr Gln Ser Pro Glu Thr Glu Ala Ser
                 485                 490                 495    
 Ala Asp Ser Phe Pro Asp Thr Lys Val Thr Tyr Val Asp Arg Lys Glu
             500                 505                 510        
 Leu Pro Gly Glu Arg Lys Thr Lys Thr Glu Ile Val Val Glu Ser Lys
         515                 520                 525            
 Leu Thr Glu Asp Val Asp Val Ser Asp Glu Ala Gly Leu Asp Tyr Leu
     530                 535                 540                
 Leu Ser Lys Asp Ile Lys Glu Val Gly Leu Lys Gly Lys Ser Ala Glu
 545                 550                 555                 560
 Gln Met Ile Gly Asp Ile Ile Asn Leu Gly Leu Lys Gly Arg Glu Gly
                 565                 570                 575    
 Arg Ala Lys Val Val Asn Val Glu Ile Val Glu Glu Pro Val Ser Tyr
             580                 585                 590        
 Val Ser Gly Glu Lys Pro Glu Glu Phe Ser Val Pro Phe Lys Val Glu
         595                 600                 605            
 Glu Val Glu Asp Val Ser Pro Gly Pro Trp Gly Leu Val Lys Glu Glu
     610                 615                 620                
 Glu Gly Tyr Gly Glu Ser Asp Val Thr Phe Ser Val Asn Gln His Arg
 625                 630                 635                 640
 Arg Thr Lys Gln Pro Gln Glu Asn Thr Thr His Val Glu Glu Val Thr
                 645                 650                 655    
 Glu Ala Gly Asp Ser Glu Gly Glu Gln Ser Tyr Phe Val Ser Thr Pro
             660                 665                 670        
 Asp Glu His Pro Gly Gly His Asp Arg Asp Asp Gly Ser Val Tyr Gly
         675                 680                 685            
 Gln Ile His Ile Glu Glu Glu Ser Thr Ile Arg Tyr Ser Trp Gln Asp
     690                 695                 700                
 Glu Ile Val Gln Gly Thr Arg Arg Arg Thr Gln Lys Asp Gly Ala Val
 705                 710                 715                 720
 Gly Glu Lys Val Val Lys Pro Leu Asp Val Pro Ala Pro Ser Leu Glu
                 725                 730                 735    
 Gly Asp Leu Gly Ser Thr His Trp Lys Glu Gln Ala Arg Ser Gly Glu
             740                 745                 750        
 Phe His Ala Glu Pro Thr Val Ile Glu Lys Glu Ile Lys Ile Pro His
         755                 760                 765            
 Glu Phe His Thr Ser Met Lys Gly Ile Ser Ser Lys Glu Pro Arg Gln
     770                 775                 780                
 Gln Leu Val Glu Val Ile Gly Gln Leu Glu Glu Thr Leu Pro Glu Arg
 785                 790                 795                 800
 Met Arg Glu Glu Leu Ser Ala Leu Thr Arg Glu Gly Gln Gly Gly Pro
                 805                 810                 815    
 Gly Ser Val Ser Val Asp Val Lys Lys Val Gln Gly Ala Gly Gly Ser
             820                 825                 830        
 Ser Val Thr Leu Val Ala Glu Val Asn Val Ser Gln Thr Val Asp Ala
         835                 840                 845            
 Asp Arg Leu Asp Leu Glu Glu Leu Ser Lys Asp Glu Ala Ser Glu Met
     850                 855                 860                
 Glu Lys Ala Val Glu Ser Val Val Arg Glu Ser Leu Ser Arg Gln Arg
 865                 870                 875                 880
 Ser Pro Ala Pro Gly Ser Pro Asp Glu Glu Gly Gly Ala Glu Ala Pro
                 885                 890                 895    
 Ala Ala Gly Ile Arg Phe Arg Arg Trp Ala Thr Arg Glu Leu Tyr Ile
             900                 905                 910        
 Pro Ser Gly Glu Ser Glu Val Ala Gly Gly Ala Ser His Ser Ser Gly
         915                 920                 925            
 Gln Arg Thr Pro Gln Gly Pro Val Ser Ala Thr Val Glu Val Ser Ser
     930                 935                 940                
 Pro Thr Gly Phe Ala Gln Ser Gln Val Leu Glu Asp Val Ser Gln Ala
 945                 950                 955                 960
 Ala Arg His Ile Lys Leu Gly Pro Ser Glu Val Trp Arg Thr Glu Arg
                 965                 970                 975    
 Met Ser Tyr Glu Gly Pro Thr Ala Glu Val Val Glu Val Ser Ala Gly
             980                 985                 990        
 Gly Asp Leu Ser Gln Ala Ala Ser Pro Thr Gly Ala Ser Arg Ser Val
         995                1000                1005            
 Arg His Val Thr Leu Gly Pro Gly Gln Ser Pro Leu Ser Arg Glu Val
    1010                1015                1020                
 Ile Phe Leu Gly Pro Ala Pro Ala Cys Pro Glu Ala Trp Gly Ser Pro
1025                1030                1035                1040
 Glu Pro Gly Pro Ala Glu Ser Ser Ala Asp Met Asp Gly Ser Gly Arg
                1045                1050                1055    
 His Ser Thr Phe Gly Cys Arg Gln Phe His Ala Glu Lys Glu Ile Ile
            1060                1065                1070        
 Phe Gln Gly Pro Ile Ser Ala Ala Gly Lys Val Gly Asp Tyr Phe Ala
        1075                1080                1085            
 Thr Glu Glu Ser Val Gly Thr Gln Thr Ser Val Arg Gln Leu Gln Leu
    1090                1095                1100                
 Gly Pro Lys Glu Gly Phe Ser Gly Gln Ile Gln Phe Thr Ala Pro Leu
1105                1110                1115                1120
 Ser Asp Lys Val Glu Leu Gly Val Ile Gly Asp Ser Val His Met Glu
                1125                1130                1135    
 Gly Leu Pro Gly Ser Ser Thr Ser Ile Arg His Ile Ser Ile Gly Pro
            1140                1145                1150        
 Gln Arg His Gln Thr Thr Gln Gln Ile Val Tyr His Gly Leu Val Pro
        1155                1160                1165            
 Gln Leu Gly Glu Ser Gly Asp Ser Glu Ser Thr Val His Gly Glu Gly
    1170                1175                1180                
 Ser Ala Asp Val His Gln Ala Thr His Ser His Thr Ser Gly Arg Gln
1185                1190                1195                1200
 Thr Val Met Thr Glu Lys Ser Thr Phe Gln Ser Val Val Ser Glu Ser
                1205                1210                1215    
 Pro Gln Glu Asp Ser Ala Gly Asp Thr Ser Gly Ala Glu Met Thr Ser
            1220                1225                1230        
 Gly Val Ser Arg Ser Phe Arg His Ile Arg Leu Gly Pro Thr Glu Thr
        1235                1240                1245            
 Glu Thr Ser Glu His Ile Ala Ile Arg Gly Pro Val Ser Arg Thr Phe
    1250                1255                1260                
 Val Leu Ala Gly Ser Ala Asp Ser Pro Glu Leu Gly Lys Leu Ala Asp
1265                1270                1275                1280
 Ser Ser Arg Thr Leu Arg His Ile Ala Pro Gly Pro Lys Glu Thr Ser
                1285                1290                1295    
 Phe Thr Phe Gln Met Asp Val Ser Asn Val Glu Ala Ile Arg Ser Arg
            1300                1305                1310        
 Thr Gln Glu Ala Gly Ala Leu Gly Val Ser Asp Arg Gly Ser Trp Arg
        1315                1320                1325            
 Asp Ala Asp Ser Arg Asn Asp Gln Ala Val Gly Val Ser Phe Lys Ala
    1330                1335                1340                
 Ser Ala Gly Glu Gly Asp Gln Ala His Arg Glu Gln Gly Lys Glu Gln
1345                1350                1355                1360
 Ala Met Phe Asp Lys Lys Val Gln Leu Gln Arg Met Val Asp Gln Arg
                1365                1370                1375    
 Ser Val Ile Ser Asp Glu Lys Lys Val Ala Leu Leu Tyr Leu Asp Asn
            1380                1385                1390        
 Glu Glu Glu Glu Asn Asp Gly His Trp Phe
        1395                1400        



      <210> 598
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 598
 Met His Gly Arg Lys Asp Asp Ala Gln Lys Gln Pro Val Lys Asn Gln
   1               5                  10                  15    
 Leu Gly Leu Asn Pro Gln Ser His Leu Pro Glu Leu Gln Leu Phe Gln
              20                  25                  30        
 Ala Glu Gly Lys Ile Tyr Lys Tyr Asp His Met Glu Lys Ser Val Asn
          35                  40                  45            
 Ser Ser Ser Leu Val Ser Pro Pro Gln Arg Ile Ser Ser Thr Val Lys
      50                  55                  60                
 Thr His Ile Ser His Thr Tyr Glu Cys Asn Phe Val Asp Ser Leu Phe
  65                  70                  75                  80
 Thr Gln Lys Glu Lys Ala Asn Ile Gly Thr Glu His Tyr Lys Cys Ser
                  85                  90                  95    
 Glu Arg Gly Lys Ala Phe His Gln Gly Leu His Phe Thr Ile His Gln
             100                 105                 110        
 Ile Ile His Thr Lys Glu Thr Gln Phe Lys Cys Asp Ile Cys Gly Lys
         115                 120                 125            
 Ile Phe Asn Lys Lys Ser Asn Leu Ala Ser His Gln Arg Ile His Thr
     130                 135                 140                
 Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe His Asn
 145                 150                 155                 160
 Met Ser His Leu Ala Gln His Arg Arg Ile His Thr Gly Glu Lys Pro
                 165                 170                 175    
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Asn Gln Ile Ser His Leu
             180                 185                 190        
 Ala Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
         195                 200                 205            
 Glu Cys Gly Lys Val Phe His Gln Ile Ser His Leu Ala Gln His Arg
     210                 215                 220                
 Thr Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Gly Lys
 225                 230                 235                 240
 Val Phe Ser Arg Asn Ser Tyr Leu Val Gln His Leu Ile Ile His Thr
                 245                 250                 255    
 Gly Glu Lys Pro Tyr Arg Cys Asn Val Cys Gly Lys Val Phe Ser His
             260                 265                 270        
 Lys Ser Ser Leu Val Asn His Trp Arg Ile His Thr Gly Glu Lys Pro
         275                 280                 285            
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser His Lys Ser Ser Leu
     290                 295                 300                
 Val Asn His Trp Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
 305                 310                 315                 320
 Glu Cys Gly Lys Val Phe Ser Arg Asn Ser Tyr Leu Ala Gln His Leu
                 325                 330                 335    
 Ile Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Asp Lys
             340                 345                 350        
 Ala Phe Ser Gln Asn Ser His Leu Val Gln His His Arg Ile His Thr
         355                 360                 365            
 Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Val Phe Ser Gln
     370                 375                 380                
 Asn Ser Tyr Leu Ala Tyr His Trp Arg Ile His Thr Gly Glu Lys Ala
 385                 390                 395                 400
 Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Gly Leu Asn Ser Ser Leu
                 405                 410                 415    
 Ala His His Arg Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn
             420                 425                 430        
 Glu Cys Gly Lys Ala Phe Ser Met Arg Ser Ser Leu Thr Asn His His
         435                 440                 445            
 Ala Ile His Thr Gly Glu Lys His Phe Lys Cys Asn Glu Cys Gly Lys
     450                 455                 460                
 Leu Phe Arg Asp Asn Ser Tyr Leu Val Arg His Gln Arg Phe His Ala
 465                 470                 475                 480
 Gly Lys Lys Ser Asn Thr Cys Asn
                 485            



      <210> 599
      <211> 277
      <212> PRT
      <213> Homo sapiens


      <400> 599
 Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val Phe Asn Gln Ser
   1               5                  10                  15    
 Asn Ile His Glu Tyr Glu Gly His His Ser Ala Glu Gln Ile Leu Glu
              20                  25                  30        
 Phe Ile Glu Asp Leu Met Asn Pro Ser Val Val Ser Leu Thr Pro Thr
          35                  40                  45            
 Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn Glu Val Trp Met
      50                  55                  60                
 Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln Val Leu Met Pro
  65                  70                  75                  80
 Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu Ile Asn Val Gly
                  85                  90                  95    
 Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala Gln Glu Asn Val
             100                 105                 110        
 Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro Pro Lys Ser Asn Lys Ala
         115                 120                 125            
 Tyr Gln Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp Ala Tyr Ser Leu
     130                 135                 140                
 Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln Val Ser Thr Asp Leu Thr
 145                 150                 155                 160
 Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys Asn His Trp Val
                 165                 170                 175    
 Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln Asn Phe Ala Pro
             180                 185                 190        
 Glu Phe Glu Leu Leu Ala Arg Met Ile Lys Gly Lys Val Lys Ala Gly
         195                 200                 205            
 Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr Cys Gln Lys Ala Gly Ile
     210                 215                 220                
 Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe Tyr Glu Arg Ala Lys Arg
 225                 230                 235                 240
 Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg Asp Ala Lys Ala Ile Ala
                 245                 250                 255    
 Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu Arg Asn Gln Gly Lys Arg
             260                 265                 270        
 Asn Lys Asp Glu Leu
         275        



      <210> 600
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 600
 Met Gln Ala Ala Cys Trp Tyr Val Leu Phe Leu Leu Gln Pro Thr Val
   1               5                  10                  15    
 Tyr Leu Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu
              20                  25                  30        
 Leu Lys Ser Gly Ser Ser Lys Ser Thr Leu Lys His Ile Trp Thr Glu
          35                  40                  45            
 Ser Ser Lys Asp Leu Ser Ile Ser Arg Leu Leu Ser Gln Thr Phe Arg
      50                  55                  60                
 Gly Lys Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu
  65                  70                  75                  80
 Pro Tyr Ser Glu Gln Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp
                  85                  90                  95    
 Leu Gln Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro Ile Val Lys Thr
             100                 105                 110        
 Gly Lys Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn Ile
         115                 120                 125            
 Lys Thr Val Lys Leu Asn Leu Leu Ile Thr Gly Lys Ile Val Asp His
     130                 135                 140                
 Gly Asn Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser Thr Gly Gln
 145                 150                 155                 160
 Gly Asn Val Ser Val Ser Leu Val Pro Pro Thr Lys Ile Val Glu Phe
                 165                 170                 175    
 Asp Leu Ala Gln Gln Thr Val Ile Asp Ala Lys Asp Ser Lys Ser Phe
             180                 185                 190        
 Asn Cys Arg Ile Glu Tyr Glu Lys Val Asp Lys Ala Thr Lys Asn Thr
         195                 200                 205            
 Leu Cys Asn Tyr Asp Pro Ser Lys Thr Cys Tyr Gln Glu Gln Thr Gln
     210                 215                 220                
 Ser His Val Ser Trp Leu Cys Ser Lys Pro Phe Lys Val Ile Cys Ile
 225                 230                 235                 240
 Tyr Ile Ser Phe Tyr Ser Thr Asp Tyr Lys Leu Val Gln Lys Val Cys
                 245                 250                 255    
 Pro Asp Tyr Asn Tyr His Ser Asp Thr Pro Tyr Phe Pro Ser Gly
             260                 265                 270    



      <210> 601
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 601
 Met Cys Tyr Thr Tyr His Cys Asp Val Gly Leu His His Val His Asp
   1               5                  10                  15    
 Pro Ala Glu Cys His Ser Ala Lys Gly His Gly Gly Glu Pro Gly Ala
              20                  25                  30        
 Thr Leu Trp Gly Gln Val Leu Leu Pro Asp Val Leu Trp Ala Phe Leu
          35                  40                  45            
 Ala Gly Asp Ser Ile
      50            



      <210> 602
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 602
 Met Lys Thr Leu Thr Arg Val Gln Pro Val Phe His Phe Lys Pro Thr
   1               5                  10                  15    
 Thr Val Val Thr Ser Cys Gln Pro Lys Asn Pro Arg Glu Leu His Arg
              20                  25                  30        
 Arg Arg Lys Leu Asp Pro Gly Lys Met His Ala Lys Ile Trp Leu Met
          35                  40                  45            
 Lys Thr Ser Leu Arg Ser Gly Arg Ala Ala Leu Arg Glu Leu Arg Ser
      50                  55                  60                
 Arg Glu Asn Phe Leu Ser Lys Leu Asn Arg Glu Leu Ile Glu Thr Ile
  65                  70                  75                  80
 Gln Glu Met Glu Asn Ser Thr Thr Leu His Val Arg Ala Leu Leu Gln
                  85                  90                  95    
 Gln Gln Asp Thr Leu Ala Thr Ile Ile Asp Ile Leu Glu Tyr Ser Asn
             100                 105                 110        
 Lys Lys Arg Leu Gln Gln Leu Lys Ser Glu Leu Gln Glu Trp Glu Glu
         115                 120                 125            
 Lys Lys Lys Cys Lys Met Ser Tyr Leu Glu Gln Gln Ala Glu Gln Leu
     130                 135                 140                
 Asn Ala Lys Ile Glu Lys Thr Gln Glu Glu Val Asn Phe Leu Ser Thr
 145                 150                 155                 160
 Tyr Met Asp His Glu Tyr Ser Ile Lys Ser Val Gln Ile Ser Thr Leu
                 165                 170                 175    
 Met Arg Gln Leu Gln Gln Val Lys Asp Ser Gln Gln Asp Glu Leu Asp
             180                 185                 190        
 Asp Leu Gly Glu Met Arg Thr Lys Val Leu Glu Ser Leu Ser Asp Lys
         195                 200                 205            
 Ile Gln Lys Lys Lys Lys Lys Ile Leu Ser Ser Val Val Ala Glu Thr
     210                 215                 220                
 Gln Arg Pro Tyr Glu Glu Ala Leu Leu Gln Lys Met Trp Glu Ser Gln
 225                 230                 235                 240
 Asp Phe Leu Lys Cys Met Gln Arg Phe Arg Glu Val Arg Gly Gln Gly
                 245                 250                 255    
 Arg Trp Trp Ser Leu
             260    



      <210> 603
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 603
 Met Tyr Ile Gly Gln Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro
   1               5                  10                  15    
 Ser Ser Pro Pro Val Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr
              20                  25                  30        
 Gly Met Pro Ser Thr His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr
          35                  40                  45            
 Leu Leu Ile Ser Thr Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly
      50                  55                  60                
 Leu Val Met Ala Val Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu
  65                  70                  75                  80
 Tyr Thr Gly Met His Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile
                  85                  90                  95    
 Thr Ala Leu Leu Ile Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp
             100                 105                 110        
 Cys Leu Asp Ser Ala Ser Pro Leu Phe Pro Val Cys Val Ile Val Val
         115                 120                 125            
 Pro Phe Phe Leu Cys Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro
     130                 135                 140                
 Thr Arg Ala Asp Thr Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr
 145                 150                 155                 160
 Ile Gly Phe Trp Ile Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala
                 165                 170                 175    
 Glu Ser Leu Pro Val Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met
             180                 185                 190        
 Leu Val Leu Gly Leu Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu
         195                 200                 205            
 Leu Val Arg Gln Leu Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser
     210                 215                 220                
 Trp Phe Lys Val Val Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu
 225                 230                 235                 240
 Ile Glu Val Pro Tyr Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Cys
                 245                 250                 255    
 Ala Thr Thr Phe Val Pro Met Leu His Arg Phe Leu Gly Leu Pro
             260                 265                 270    



      <210> 604
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 604
 Met Asn Gly Arg Val Asp Tyr Leu Val Thr Glu Glu Glu Ile Asn Leu
   1               5                  10                  15    
 Thr Arg Gly Pro Ser Gly Leu Gly Phe Asn Ile Val Gly Gly Thr Asp
              20                  25                  30        
 Gln Gln Tyr Val Ser Asn Asp Ser Gly Ile Tyr Val Ser Arg Ile Lys
          35                  40                  45            
 Glu Asn Gly Ala Ala Ala Leu Asp Gly Arg Leu Gln Glu Gly Asp Lys
      50                  55                  60                
 Ile Leu Ser Val Asn Gly Gln Asp Leu Lys Asn Leu Leu His Gln Asp
  65                  70                  75                  80
 Ala Val Asp Leu Phe Arg Asn Ala Gly Tyr Ala Val Ser Leu Arg Val
                  85                  90                  95    
 Gln His Arg Leu Gln Val Gln Asn Gly Pro Ile Gly His Arg Gly Glu
             100                 105                 110        
 Gly Asp Pro Ser Gly Ile Pro Ile Phe Met Val Leu Val Pro Val Phe
         115                 120                 125            
 Ala Leu Thr Met Val Ala Ala Trp Ala Phe Met Arg Tyr Arg Gln Gln
     130                 135                 140                
 Leu
 145



      <210> 605
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 605
 Met Ser Gly Phe Ser Leu Ser Ser Pro Gly Val Ile Gly Tyr Leu His
   1               5                  10                  15    
 Arg Leu Ser Asp Pro Thr Leu His Ser His Pro Phe Leu Ser Pro Arg
              20                  25                  30        
 Ser Cys Pro Ala Leu His Ser Thr Ala Gly Met Leu Gly Thr Glu Ala
          35                  40                  45            
 Leu Ala Ala Pro Gln Cys Thr Gly Leu Pro Ser Leu Gly Val Gly Phe
      50                  55                  60                
 Phe Pro Gly Leu Ala Trp Ala Leu Pro Thr Ser Thr Pro Ser Gly Arg
  65                  70                  75                  80
 Gly Cys Arg Leu Met Leu Phe Pro Asp Gly Asp Pro Glu Ile Phe Pro
                  85                  90                  95    
 Thr Pro Asn His Asp Val Phe Ser Val Gly Leu Gly Ser Ser Trp Phe
             100                 105                 110        
 Cys Leu Gln Pro Ala Trp Leu Arg Pro
         115                 120    



      <210> 606
      <211> 1562
      <212> PRT
      <213> Homo sapiens


      <400> 606
 Met Pro Gly Glu Ala Ala Arg Ala Glu Leu Leu Leu Pro Glu Ala Asp
   1               5                  10                  15    
 Arg Pro Gly Pro Arg Thr Asp Leu Ser Cys Asp Ala Ala Ala Ala Thr
              20                  25                  30        
 Thr Ile Leu Gly Gly Asp Arg Arg Glu Pro Cys Ala Leu Thr Pro Gly
          35                  40                  45            
 Pro Ser His Leu Ala Leu Thr Phe Leu Pro Ser Lys Pro Gly Ala Arg
      50                  55                  60                
 Pro Gln Pro Glu Gly Ala Ser Trp Asp Ala Gly Pro Gly Gly Ala Pro
  65                  70                  75                  80
 Ser Ala Trp Ala Asp Pro Gly Glu Gly Gly Pro Ser Pro Met Leu Leu
                  85                  90                  95    
 Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr Glu Ala Pro Leu Pro
             100                 105                 110        
 Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu Glu Thr Cys Gln Ala
         115                 120                 125            
 Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu Arg Asp Gln Glu Gly
     130                 135                 140                
 Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu Cys Ser Gln Gly Asp
 145                 150                 155                 160
 Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp Ser Phe Phe Thr Pro
                 165                 170                 175    
 Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu Leu Pro Ala Cys Gly
             180                 185                 190        
 Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu Leu Arg Asp Glu Leu
         195                 200                 205            
 Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser Tyr Ile Thr Ala Asp
     210                 215                 220                
 Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser Leu Ser Leu Leu Ala
 225                 230                 235                 240
 Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp Gly Leu Ser Pro Gln
                 245                 250                 255    
 Gly Ser Met Val Asp Glu Arg Glu Leu His Pro Ala Gly Thr Pro Glu
             260                 265                 270        
 Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp Ser Ser Ser Ser Trp
         275                 280                 285            
 Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe Leu Ala Asn Asp Pro
     290                 295                 300                
 Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly Ser Leu Ile Phe Gln
 305                 310                 315                 320
 Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro Glu Glu Glu Glu Glu
                 325                 330                 335    
 Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp Leu Ala Gly Glu Gly
             340                 345                 350        
 Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln Ser Leu Ser Asp Leu
         355                 360                 365            
 Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala Phe Arg Asp Asp Thr
     370                 375                 380                
 Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser Tyr Ala Glu Ala Asp
 385                 390                 395                 400
 Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala Gln Ala Thr Leu Leu
                 405                 410                 415    
 Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser Gly Gly Gly Ala Lys
             420                 425                 430        
 Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp Ala Val Glu Ala Ala
         435                 440                 445            
 Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser Gln Arg Gln Glu Leu
     450                 455                 460                
 Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu Gly Gln Glu Ser Thr
 465                 470                 475                 480
 Ala Thr Val Thr Pro His Thr Leu Gln Val Ala Pro Gly Leu Gln Val
                 485                 490                 495    
 Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly Glu Glu Glu Thr Asp
             500                 505                 510        
 Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala Met Pro Gln Pro Ser
         515                 520                 525            
 Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu Ser Val Thr Ala Glu
     530                 535                 540                
 Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu Thr Leu Cys Pro Asp
 545                 550                 555                 560
 Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu Asp Leu Pro Ser Gly
                 565                 570                 575    
 Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro Arg Gln Ala Glu Glu
             580                 585                 590        
 Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         595                 600                 605            
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     610                 615                 620                
 Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 625                 630                 635                 640
 Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 645                 650                 655    
 Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu
             660                 665                 670        
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         675                 680                 685            
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     690                 695                 700                
 Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 705                 710                 715                 720
 Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 725                 730                 735    
 Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu
             740                 745                 750        
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         755                 760                 765            
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     770                 775                 780                
 Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 785                 790                 795                 800
 Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 805                 810                 815    
 Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu
             820                 825                 830        
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu
         835                 840                 845            
 Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr
     850                 855                 860                
 Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser
 865                 870                 875                 880
 Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala
                 885                 890                 895    
 Pro Lys Pro Val Ala Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu
             900                 905                 910        
 Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Ala Pro Leu Pro Leu
         915                 920                 925            
 Gln Asp Thr Gly Pro Thr Ser Gly Pro Glu Pro Leu Ala Val Ala Thr
     930                 935                 940                
 Pro Gln Thr Leu Gln Ala Glu Ala Gly Cys Ala Pro Gly Thr Glu Pro
 945                 950                 955                 960
 Val Ala Thr Met Ala Gln Gln Glu Val Gly Glu Ala Leu Gly Pro Arg
                 965                 970                 975    
 Pro Ala Pro Glu Glu Lys Asn Ala Ala Leu Pro Thr Val Pro Glu Pro
             980                 985                 990        
 Ala Ala Leu Asp Gln Val Gln Gln Asp Asp Pro Gln Pro Ala Ala Glu
         995                1000                1005            
 Ala Gly Thr Pro Trp Ala Ala Gln Glu Asp Ala Asp Ser Thr Leu Gly
    1010                1015                1020                
 Met Glu Ala Leu Ser Leu Pro Glu Pro Ala Ser Gly Ala Gly Glu Glu
1025                1030                1035                1040
 Ile Ala Glu Ala Leu Ser Arg Pro Gly Arg Glu Ala Cys Leu Glu Ala
                1045                1050                1055    
 Arg Ala His Thr Gly Asp Gly Ala Lys Pro Asp Ser Pro Gln Lys Glu
            1060                1065                1070        
 Thr Leu Glu Val Glu Asn Gln Gln Glu Gly Gly Leu Lys Pro Leu Ala
        1075                1080                1085            
 Gln Glu His Gly Pro Arg Ser Ala Leu Gly Gly Ala Arg Glu Val Pro
    1090                1095                1100                
 Asp Ala Pro Pro Ala Ala Cys Pro Glu Val Ser Gln Ala Arg Leu Leu
1105                1110                1115                1120
 Ser Pro Ala Arg Glu Glu Arg Gly Leu Ser Gly Lys Ser Thr Pro Glu
                1125                1130                1135    
 Pro Thr Leu Pro Ser Ala Val Ala Thr Glu Ala Ser Leu Asp Ser Cys
            1140                1145                1150        
 Pro Glu Ser Ser Val Gly Ala Val Ser Ser Leu Asp Arg Gly Cys Pro
        1155                1160                1165            
 Asp Ala Pro Ala Pro Thr Ser Ala Pro Thr Ser Gln Gln Pro Glu Pro
    1170                1175                1180                
 Val Leu Gly Leu Gly Ser Val Glu Gln Pro His Glu Val Pro Ser Val
1185                1190                1195                1200
 Leu Gly Thr Pro Leu Leu Gln Pro Pro Glu Asn Leu Ala Lys Gly Gln
                1205                1210                1215    
 Pro Ser Thr Pro Val Asp Arg Pro Leu Gly Pro Asp Pro Ser Ala Pro
            1220                1225                1230        
 Gly Thr Leu Ala Gly Ala Ala Leu Pro Pro Leu Glu Pro Pro Ala Pro
        1235                1240                1245            
 Cys Leu Cys Gln Asp Pro Gln Glu Asp Ser Val Glu Asp Glu Glu Pro
    1250                1255                1260                
 Pro Gly Ser Leu Gly Leu Pro Pro Pro Gln Ala Gly Val Gln Pro Ala
1265                1270                1275                1280
 Ala Ala Ala Val Ser Gly Thr Thr Gln Pro Leu Gly Thr Gly Pro Arg
                1285                1290                1295    
 Val Ser Leu Ser Pro His Ser Pro Leu Leu Ser Pro Lys Val Ala Ser
            1300                1305                1310        
 Met Asp Ala Lys Asp Leu Ala Leu Gln Ile Leu Pro Pro Cys Gln Val
        1315                1320                1325            
 Pro Pro Pro Ser Gly Pro Gln Ser Pro Ala Gly Pro Gln Gly Leu Ser
    1330                1335                1340                
 Ala Pro Glu Gln Gln Glu Asp Glu Asp Ser Leu Glu Glu Asp Ser Pro
1345                1350                1355                1360
 Arg Ala Leu Gly Ser Gly Gln His Ser Asp Ser His Gly Glu Ser Ser
                1365                1370                1375    
 Ala Glu Leu Asp Glu Gln Asp Ile Leu Ala Pro Gln Thr Val Gln Cys
            1380                1385                1390        
 Pro Ala Gln Ala Pro Ala Gly Gly Ser Glu Glu Thr Ile Ala Lys Ala
        1395                1400                1405            
 Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met Ser Lys Leu
    1410                1415                1420                
 Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile Thr Ile Gln Lys Ser
1425                1430                1435                1440
 Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp Val Phe Lys Ser Pro
                1445                1450                1455    
 Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala Lys Ile Glu Asp Leu
            1460                1465                1470        
 Ser Gln Gln Val His Lys Ala Ala Ala Glu Lys Phe Lys Val Pro Ser
        1475                1480                1485            
 Glu Pro Ser Ala Leu Val Pro Glu Ser Ala Pro Arg Pro Arg Val Arg
    1490                1495                1500                
 Leu Glu Cys Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Glu
1505                1510                1515                1520
 Ala Gly Leu Glu Leu Arg Asp Ile Glu Leu Val Met Ala Gln Ala Asn
                1525                1530                1535    
 Val Ser Arg Ala Lys Ala Val Arg Ala Leu Arg Asp Asn His Ser Asp
            1540                1545                1550        
 Ile Val Asn Ala Ile Met Glu Leu Thr Met
        1555                1560        



      <210> 607
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 607
 Met Asp Pro Leu Ile Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser
   1               5                  10                  15    
 Gln Glu Leu Phe Arg Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp
              20                  25                  30        
 Pro Tyr Glu Val Ser Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val
          35                  40                  45            
 Leu Tyr Glu Ala Ser Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn
      50                  55                  60                
 Val Gln Met Val Asp Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu
  65                  70                  75                  80
 Gly Arg Thr Ser Pro Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly
                  85                  90                  95    





      <210> 608
      <211> 600
      <212> PRT
      <213> Homo sapiens


      <400> 608
 Met Asn Gly Ser Arg Arg Val Arg Ala Thr Ser Val Leu Pro Arg Tyr
   1               5                  10                  15    
 Gly Pro Pro Cys Leu Phe Lys Gly His Leu Ser Thr Lys Ser Asn Ala
              20                  25                  30        
 Phe Cys Thr Asp Ser Ser Ser Leu Arg Leu Ser Thr Leu Gln Leu Val
          35                  40                  45            
 Lys Asn His Met Ala Val His Tyr Asn Lys Ile Leu Ser Ala Lys Ala
      50                  55                  60                
 Ala Val Asp Cys Ser Val Pro Val Ser Val Ser Thr Ser Ile Lys Tyr
  65                  70                  75                  80
 Ala Asp Gln Gln Arg Arg Glu Lys Leu Lys Lys Glu Leu Ala Gln Cys
                  85                  90                  95    
 Glu Lys Glu Phe Lys Leu Thr Lys Thr Ala Met Arg Ala Asn Tyr Lys
             100                 105                 110        
 Asn Asn Ser Lys Ser Leu Phe Asn Thr Leu Gln Lys Pro Ser Gly Glu
         115                 120                 125            
 Pro Gln Ile Glu Asp Asp Met Leu Lys Glu Glu Met Asn Gly Phe Ser
     130                 135                 140                
 Ser Phe Ala Arg Ser Leu Val Pro Ser Ser Glu Arg Leu His Leu Ser
 145                 150                 155                 160
 Leu His Lys Ser Ser Lys Val Ile Thr Asn Gly Pro Glu Lys Asn Ser
                 165                 170                 175    
 Ser Ser Ser Pro Ser Ser Val Asp Tyr Ala Ala Ser Gly Pro Arg Lys
             180                 185                 190        
 Leu Ser Ser Gly Ala Leu Tyr Gly Arg Arg Pro Arg Ser Thr Phe Pro
         195                 200                 205            
 Asn Ser His Arg Phe Gln Leu Val Ile Ser Lys Ala Pro Ser Gly Asp
     210                 215                 220                
 Leu Leu Asp Lys His Ser Glu Leu Phe Ser Asn Lys Gln Leu Pro Phe
 225                 230                 235                 240
 Thr Pro Arg Thr Leu Lys Thr Glu Ala Lys Ser Phe Leu Ser Gln Tyr
                 245                 250                 255    
 Arg Tyr Tyr Thr Pro Ala Lys Arg Lys Lys Asp Phe Thr Asp Gln Arg
             260                 265                 270        
 Ile Glu Ala Glu Thr Gln Thr Glu Leu Ser Phe Lys Ser Glu Leu Gly
         275                 280                 285            
 Thr Ala Glu Thr Lys Asn Met Thr Asp Ser Glu Met Asn Ile Lys Gln
     290                 295                 300                
 Val Ala Ser Asn Cys Val Thr Tyr Asp Ala Lys Glu Lys Ile Ala Pro
 305                 310                 315                 320
 Leu Pro Leu Glu Glu His Asp Ser Thr Trp Asp Glu Ile Lys Asp Asp
                 325                 330                 335    
 Ala Leu Gln His Ser Ser Pro Arg Ala Met Cys Gln Tyr Ser Leu Lys
             340                 345                 350        
 Pro Pro Ser Thr Arg Lys Ile Tyr Ser Asp Glu Glu Glu Leu Leu Tyr
         355                 360                 365            
 Leu Ser Phe Ile Glu Asp Val Thr Asp Glu Ile Leu Lys Leu Gly Leu
     370                 375                 380                
 Phe Ser Asn Arg Phe Leu Glu Arg Leu Phe Glu Arg His Ile Lys Gln
 385                 390                 395                 400
 Asn Lys His Leu Glu Glu Glu Lys Met Arg His Leu Leu His Val Leu
                 405                 410                 415    
 Lys Val Asp Leu Gly Cys Thr Ser Glu Glu Asn Ser Val Lys Gln Asn
             420                 425                 430        
 Asp Val Asp Met Leu Asn Val Phe Asp Phe Glu Lys Ala Gly Asn Ser
         435                 440                 445            
 Glu Pro Asn Glu Leu Lys Asn Glu Ser Glu Val Thr Ile Gln Gln Glu
     450                 455                 460                
 Arg Gln Gln Tyr Gln Lys Ala Leu Asp Met Leu Leu Ser Ala Pro Lys
 465                 470                 475                 480
 Asp Glu Asn Glu Ile Phe Pro Ser Pro Thr Glu Phe Phe Met Pro Ile
                 485                 490                 495    
 Tyr Lys Ser Lys His Ser Glu Gly Val Ile Ile Gln Gln Val Asn Asp
             500                 505                 510        
 Glu Thr Asn Leu Glu Thr Ser Thr Leu Asp Glu Asn His Pro Ser Ile
         515                 520                 525            
 Ser Asp Ser Leu Thr Asp Arg Glu Thr Ser Val Asn Val Ile Glu Gly
     530                 535                 540                
 Asp Ser Asp Pro Glu Lys Val Glu Ile Ser Asn Gly Leu Cys Gly Leu
 545                 550                 555                 560
 Asn Thr Ser Pro Ser Gln Ser Val Gln Phe Ser Ser Val Lys Gly Asp
                 565                 570                 575    
 Asn Asn His Asp Met Glu Leu Ser Thr Leu Lys Ile Met Glu Met Ser
             580                 585                 590        
 Ile Glu Asp Cys Pro Leu Asp Val
         595                 600



      <210> 609
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 609
 Met Asp Val Lys Cys Pro Gly Cys Tyr Lys Ile Thr Thr Val Phe Ser
   1               5                  10                  15    
 His Ala Gln Thr Val Val Leu Cys Val Gly Cys Ser Thr Val Leu Cys
              20                  25                  30        
 Gln Pro Thr Gly Gly Lys Ala Arg Leu Thr Glu Gly Cys Ser Phe Arg
          35                  40                  45            
 Arg Lys Gln His
      50        



      <210> 610
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 610
 Met Ala Ser Ser Thr Val Pro Val Ser Ala Ala Gly Ser Ala Asn Glu
   1               5                  10                  15    
 Thr Pro Glu Ile Pro Asp Asn Val Gly Asp Trp Leu Arg Gly Val Tyr
              20                  25                  30        
 Arg Phe Ala Thr Asp Arg Asn Asp Phe Arg Arg Asn Leu Ile Leu Asn
          35                  40                  45            
 Leu Gly Leu Phe Ala Ala Gly Val Trp Leu Ala Arg Asn Leu Ser Asp
      50                  55                  60                
 Ile Asp Leu Met Ala Pro Gln Pro Gly Val
  65                  70                



      <210> 611
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 611
 Met Gly Val Gln Pro Pro Asn Phe Ser Trp Val Leu Pro Gly Arg Leu
   1               5                  10                  15    
 Ala Gly Leu Ala Leu Pro Arg Leu Pro Ala His Tyr Gln Phe Leu Leu
              20                  25                  30        
 Asp Leu Gly Val Arg His Leu Val Ser Leu Thr Glu Arg Gly Pro Pro
          35                  40                  45            
 His Ser Asp Ser Cys Pro Gly Leu Thr Leu His Arg Leu Arg Ile Pro
      50                  55                  60                
 Asp Phe Cys Pro Pro Ala Pro Asp Gln Ile Asp Arg Phe Val Gln Ile
  65                  70                  75                  80
 Val Asp Glu Ala Asn Ala Arg Gly Glu Ala Val Gly Val His Cys Ala
                  85                  90                  95    
 Leu Gly Phe Gly Arg Thr Gly Thr Met Leu Ala Cys Tyr Leu Val Lys
             100                 105                 110        
 Glu Arg Gly Leu Ala Ala Gly Asp Ala Ile Ala Glu Ile Arg Arg Leu
         115                 120                 125            
 Arg Pro Gly Ser Ile Glu Thr Tyr Glu Gln Glu Lys Ala Val Phe Gln
     130                 135                 140                
 Phe Tyr Gln Arg Thr Lys
 145                 150



      <210> 612
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 612
 Met Arg Glu Ile Val Trp Tyr Arg Val Thr Asp Gly Gly Thr Ile Lys
   1               5                  10                  15    
 Gln Lys Ile Phe Thr Phe Asp Ala Met Phe Ser Thr Asn Tyr Ser His
              20                  25                  30        
 Met Glu Asn Tyr Arg Lys Arg Glu Asp Leu Val Tyr Gln Ser Thr Val
          35                  40                  45            
 Arg Leu Pro Glu Val Arg Ile Ser Asp Asn Gly Pro Tyr Glu Cys His
      50                  55                  60                
 Val Gly Ile Tyr Asp Arg Ala Thr Arg Glu Lys Val Val Leu Ala Ser
  65                  70                  75                  80
 Gly Asn Ile Phe Leu Asn Val Met Ala Pro Pro Thr Ser Ile Glu Val
                  85                  90                  95    
 Val Ala Ala Asp Thr Pro Ala Pro Phe Ser Arg Tyr Gln Ala Gln Asn
             100                 105                 110        
 Phe Thr Leu Val Cys Ile Val Ser Gly Gly Lys Pro Ala Pro Met Val
         115                 120                 125            
 Tyr Phe Lys Arg Asp Gly Glu Pro Ile Asp Ala Val Pro Leu Ser Glu
     130                 135                 140                
 Pro Pro Ala Ala Ser Ser Gly Pro Leu Gln Asp Ser Arg Pro Phe Arg
 145                 150                 155                 160
 Ser Leu Leu His Arg Asp Leu Asp Asp Thr Lys Met Gln Lys Ser Leu
                 165                 170                 175    
 Ser Leu Leu Asp Ala Glu Asn Arg Gly Gly Arg Pro Tyr Thr Glu Arg
             180                 185                 190        
 Pro Ser Arg Gly Leu Thr Pro Asp Pro Asn Ile Leu Leu Gln Pro Thr
         195                 200                 205            
 Thr Glu Asn Ile Pro Glu Thr Val Val Ser Arg Glu Phe Pro Arg Trp
     210                 215                 220                
 Val His Ser Ala Glu Pro Thr Tyr Phe Leu Arg His Ser Arg Thr Pro
 225                 230                 235                 240
 Ser Ser Asp Gly Thr Val Glu Val Arg Ala Leu Leu Thr Trp Thr Leu
                 245                 250                 255    
 Asn Pro Gln Ile Asp Asn Glu Ala Leu Phe Ser Cys Glu Val Lys His
             260                 265                 270        
 Pro Ala Leu Ser Met Pro Met Gln Ala Glu Val Thr Leu Val Ala Pro
         275                 280                 285            
 Lys Gly Pro Lys Ile Val Met Thr Pro Ser Arg Ala Arg Val Gly Asp
     290                 295                 300                
 Thr Val Arg Ile Leu Val His Gly Phe Gln Asn Glu Val Phe Pro Glu
 305                 310                 315                 320
 Pro Met Phe Thr Trp Thr Arg Val Gly Ser Arg Leu Leu Asp Gly Ser
                 325                 330                 335    
 Ala Glu Phe Asp Gly Lys Glu Leu Val Leu Glu Arg Val Pro Ala Glu
             340                 345                 350        
 Leu Asn Gly Ser Met Tyr Arg Cys Thr Ala Gln Asn Pro Leu Gly Ser
         355                 360                 365            
 Thr Asp Thr His Thr Arg Leu Ile Val Phe Glu Asn Pro Asn Ile Pro
     370                 375                 380                
 Arg Gly Thr Glu Asp Ser Asn Gly Ser Ile Gly Pro Thr Gly Ala Arg
 385                 390                 395                 400
 Leu Thr Leu Val Leu Ala Leu Thr Val Ile Leu Glu Leu Thr
                 405                 410                



      <210> 613
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 613
 Met Arg Pro Gly Lys Lys Val Leu Val Met Gly Ile Val Asp Leu Asn
   1               5                  10                  15    
 Pro Glu Ser Phe Ala Ile Ser Leu Thr Cys Gly Asp Ser Glu Asp Pro
              20                  25                  30        
 Pro Ala Asp Val Ala Ile Glu Leu Lys Ala Val Phe Thr Asp Arg Gln
          35                  40                  45            
 Leu Leu Arg Asn Ser Cys Ile Ser Gly Glu Arg Gly Glu Glu Gln Ser
      50                  55                  60                
 Ala Ile Pro Tyr Phe Pro Phe Ile Pro Asp Gln Pro Phe Arg Val Glu
  65                  70                  75                  80
 Ile Leu Cys Glu His Pro Arg Phe Arg Val Phe Val Asp Gly His Gln
                  85                  90                  95    
 Leu Phe Asp Phe Tyr His Arg Ile Gln Thr Leu Ser Ala Ile Asp Thr
             100                 105                 110        
 Ile Lys Ile Asn Gly Asp Leu Gln Ile Thr Lys Leu Gly
         115                 120                 125



      <210> 614
      <211> 1497
      <212> PRT
      <213> Homo sapiens


      <400> 614
 Met Asp Val Thr Lys Lys Asn Lys Arg Asp Gly Thr Glu Val Thr Glu
   1               5                  10                  15    
 Arg Ile Val Thr Glu Thr Val Thr Thr Arg Leu Thr Ser Leu Pro Pro
              20                  25                  30        
 Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys Thr Ala Ser Leu Gly Gly
          35                  40                  45            
 Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr
      50                  55                  60                
 Ile Asn Ser Thr Gly Ser Thr Arg Gly His Ala Ser Thr Ser Ser Tyr
  65                  70                  75                  80
 Arg Arg Ala His Ser Pro Ala Ser Thr Leu Pro Asn Ser Pro Gly Ser
                  85                  90                  95    
 Thr Phe Glu Arg Lys Thr His Val Thr Arg His Ala Tyr Glu Gly Ser
             100                 105                 110        
 Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro Arg Lys Glu Phe Ala Ser
         115                 120                 125            
 Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg Glu Ser Glu Ile Arg Val
     130                 135                 140                
 Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg Trp Thr Glu Leu Asp Asp
 145                 150                 155                 160
 Val Lys Arg Leu Leu Lys Gly Ser Arg Ser Ala Ser Val Ser Pro Thr
                 165                 170                 175    
 Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro Lys Lys Gly Thr Val Glu
             180                 185                 190        
 Thr Lys Ile Val Thr Ala Ser Ser Gln Ser Val Ser Gly Thr Tyr Asp
         195                 200                 205            
 Ala Met Ile Leu Asp Ala Asn Leu Pro Ser His Val Trp Ser Ser Thr
     210                 215                 220                
 Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr His Asn Asn Met Thr Thr
 225                 230                 235                 240
 Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala Tyr Ser Ala Gly Ser Val
                 245                 250                 255    
 Phe Gly Val Pro Asn Asn Met Ala Ser Cys Ser Pro Thr Leu His Pro
             260                 265                 270        
 Gly Leu Ser Thr Ser Ser Ser Val Phe Gly Met Gln Asn Asn Leu Ala
         275                 280                 285            
 Pro Ser Leu Thr Thr Leu Ser His Gly Thr Thr Thr Thr Ser Thr Ala
     290                 295                 300                
 Tyr Gly Val Lys Lys Asn Met Pro Gln Ser Pro Ala Ala Val Asn Thr
 305                 310                 315                 320
 Gly Val Ser Thr Ser Ala Ala Cys Thr Thr Ser Val Gln Ser Asp Asp
                 325                 330                 335    
 Leu Leu His Lys Asp Cys Lys Phe Leu Ile Leu Glu Lys Asp Asn Thr
             340                 345                 350        
 Pro Ala Lys Lys Glu Met Glu Leu Leu Ile Met Thr Lys Asp Ser Gly
         355                 360                 365            
 Lys Val Phe Thr Ala Ser Pro Ala Ser Ile Ala Ala Thr Ser Phe Ser
     370                 375                 380                
 Glu Asp Thr Leu Lys Lys Lys Lys Gln Ala Ala Tyr Asn Ala Asp Ser
 385                 390                 395                 400
 Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu Lys Thr Val Ser Thr Lys
                 405                 410                 415    
 Gly Lys Thr Thr Thr Ala Asp Ile His Ser Tyr Ser Ser Ser Gly Gly
             420                 425                 430        
 Gly Gly Ser Gly Gly Gly Gly Gly Val Gly Gly Ala Gly Gly Gly Pro
         435                 440                 445            
 Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys Gly Ser Cys Cys Ser Trp
     450                 455                 460                
 Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr Trp Leu Leu Leu Leu Gly
 465                 470                 475                 480
 Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu Glu Val Arg Lys Leu Lys
                 485                 490                 495    
 Ala Arg Val Asp Glu Leu Glu Arg Ile Arg Arg Ser Ile Leu Pro Tyr
             500                 505                 510        
 Gly Asp Ser Met Asp Arg Ile Glu Lys Asp Arg Leu Gln Gly Met Ala
         515                 520                 525            
 Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile Gly Leu His Ser Asp Ser
     530                 535                 540                
 Gln Glu Glu Leu Trp Met Phe Val Arg Lys Lys Leu Met Met Glu Gln
 545                 550                 555                 560
 Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly Pro Lys Gly Asp Met Gly
                 565                 570                 575    
 Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile
             580                 585                 590        
 Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys
         595                 600                 605            
 Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Met Gly Gln Arg Gly
     610                 615                 620                
 Arg Glu Gly Pro Met Gly Pro Arg Gly Glu Ala Gly Pro Pro Gly Ser
 625                 630                 635                 640
 Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly
                 645                 650                 655    
 Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser
             660                 665                 670        
 Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg
         675                 680                 685            
 Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Val Gly
     690                 695                 700                
 Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Arg Gly Leu
 705                 710                 715                 720
 Thr Gly Glu Pro Gly Met Arg Gly Leu Pro Gly Ala Val Gly Glu Pro
                 725                 730                 735    
 Gly Ala Lys Gly Ala Met Gly Pro Ala Gly Pro Asp Gly His Gln Gly
             740                 745                 750        
 Pro Arg Gly Glu Gln Gly Leu Thr Gly Met Pro Gly Ile Arg Gly Pro
         755                 760                 765            
 Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro Gly Leu Thr Gly Pro Gln
     770                 775                 780                
 Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly Arg Pro Gly Ile Lys Gly
 785                 790                 795                 800
 Glu Pro Gly Ala Pro Gly Lys Ile Val Thr Ser Glu Gly Ser Ser Met
                 805                 810                 815    
 Leu Thr Val Pro Gly Pro Pro Gly Pro Pro Gly Ala Met Gly Pro Pro
             820                 825                 830        
 Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Ala Gly Leu Pro Gly
         835                 840                 845            
 His Gln Glu Val Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro
     850                 855                 860                
 Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly Pro Pro Gly Pro Arg Gly
 865                 870                 875                 880
 Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Phe
                 885                 890                 895    
 Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly Pro Pro Gly Pro Pro Gly
             900                 905                 910        
 Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His
         915                 920                 925            
 Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Thr Ser Gly Ser Ser Ser
     930                 935                 940                
 Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly
 945                 950                 955                 960
 Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile
                 965                 970                 975    
 Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser Ser Thr Met Tyr Val Ser
             980                 985                 990        
 Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Ile Ser
         995                1000                1005            
 Ser Ser Gly Gln Glu Ile Gln Gln Tyr Ile Ser Glu Tyr Met Gln Ser
    1010                1015                1020                
 Asp Ser Ile Arg Ser Tyr Leu Ser Gly Val Gln Gly Pro Pro Gly Pro
1025                1030                1035                1040
 Pro Gly Pro Pro Gly Pro Val Thr Thr Ile Thr Gly Glu Thr Phe Asp
                1045                1050                1055    
 Tyr Ser Glu Leu Ala Ser His Val Val Ser Tyr Leu Arg Thr Ser Gly
            1060                1065                1070        
 Tyr Gly Val Ser Leu Phe Ser Ser Ser Ile Ser Ser Glu Asp Ile Leu
        1075                1080                1085            
 Ala Val Leu Gln Arg Asp Asp Val Arg Gln Tyr Leu Arg Gln Tyr Leu
    1090                1095                1100                
 Met Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Ala Ser Gly Asp Gly
1105                1110                1115                1120
 Ser Leu Leu Ser Leu Asp Tyr Ala Glu Leu Ser Ser Arg Ile Leu Ser
                1125                1130                1135    
 Tyr Met Ser Ser Ser Gly Ile Ser Ile Gly Leu Pro Gly Pro Pro Gly
            1140                1145                1150        
 Pro Pro Gly Leu Pro Gly Thr Ser Tyr Glu Glu Leu Leu Ser Leu Leu
        1155                1160                1165            
 Arg Gly Ser Glu Phe Arg Gly Ile Val Gly Pro Pro Gly Pro Pro Gly
    1170                1175                1180                
 Pro Pro Gly Ile Pro Gly Asn Val Trp Ser Ser Ile Ser Val Glu Asp
1185                1190                1195                1200
 Leu Ser Ser Tyr Leu His Thr Ala Gly Leu Ser Phe Ile Pro Gly Pro
                1205                1210                1215    
 Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Val Ser
            1220                1225                1230        
 Gly Ala Leu Ala Thr Tyr Ala Ala Glu Asn Ser Asp Ser Phe Arg Ser
        1235                1240                1245            
 Glu Leu Ile Ser Tyr Leu Thr Ser Pro Asp Val Arg Ser Phe Ile Val
    1250                1255                1260                
 Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Asp Ser Arg
1265                1270                1275                1280
 Leu Leu Ser Thr Asp Ala Ser His Ser Arg Gly Ser Ser Ser Ser Ser
                1285                1290                1295    
 His Ser Ser Ser Val Arg Arg Gly Ser Ser Tyr Ser Ser Ser Met Ser
            1300                1305                1310        
 Thr Gly Gly Gly Gly Ala Gly Ser Leu Gly Ala Gly Gly Ala Phe Gly
        1315                1320                1325            
 Glu Ala Ala Gly Asp Arg Gly Pro Tyr Gly Thr Asp Ile Gly Pro Gly
    1330                1335                1340                
 Gly Gly Tyr Gly Ala Ala Ala Glu Gly Gly Met Tyr Ala Gly Asn Gly
1345                1350                1355                1360
 Gly Leu Leu Gly Ala Asp Phe Ala Gly Gly Leu Asp Tyr Asn Glu Leu
                1365                1370                1375    
 Ala Val Arg Val Ser Glu Ser Met Gln Arg Gln Gly Leu Leu Gln Gly
            1380                1385                1390        
 Met Ala Tyr Thr Val Gln Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly
        1395                1400                1405            
 Pro Pro Gly Ile Ser Lys Val Phe Ser Ala Tyr Ser Asn Val Thr Ala
    1410                1415                1420                
 Asp Leu Met Asp Phe Phe Gln Thr Tyr Gly Ala Ile Gln Gly Pro Pro
1425                1430                1435                1440
 Gly Gln Lys Gly Glu Met Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly
                1445                1450                1455    
 Pro Ala Gly Pro Pro Gly His Pro Gly Pro Pro Gly Pro Arg Gly His
            1460                1465                1470        
 Lys Gly Glu Lys Gly Asp Lys Gly Asp Gln Val Tyr Ala Gly Arg Arg
        1475                1480                1485            
 Arg Arg Arg Ser Ile Ala Val Lys Pro
    1490                1495        



      <210> 615
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 615
 Met Gly Leu Val Ser Trp Thr Asp Leu Ile Gln Arg Leu Leu Gly Ser
   1               5                  10                  15    
 Ala Val Gln Met Thr Leu Trp Thr Tyr Phe Pro Ala Met Phe Gln Asp
              20                  25                  30        
 Asp Gly Glu Glu Ser Ser Pro Thr Ala Ser Met Leu Ser Leu Phe Arg
          35                  40                  45            





      <210> 616
      <211> 498
      <212> PRT
      <213> Homo sapiens


      <400> 616
 Met Ala Ala Ala Ala Gly Pro Gly Ala Ala Leu Ser Pro Arg Pro Cys
   1               5                  10                  15    
 Asp Ser Asp Pro Ala Thr Pro Gly Ala Gln Ser Pro Lys Asp Asp Asn
              20                  25                  30        
 Glu Asp Asn Ser Asn Asp Gly Thr Gln Pro Ser Lys Arg Arg Arg Met
          35                  40                  45            
 Gly Ser Gly Asp Ser Ser Arg Ser Cys Glu Thr Ser Ser Gln Asp Leu
      50                  55                  60                
 Gly Phe Ser Tyr Tyr Pro Ala Glu Asn Leu Ile Glu Tyr Lys Trp Pro
  65                  70                  75                  80
 Pro Asp Glu Thr Gly Glu Tyr Tyr Met Leu Gln Glu Gln Val Ser Glu
                  85                  90                  95    
 Tyr Leu Gly Val Thr Ser Phe Lys Arg Lys Tyr Pro Asp Leu Glu Arg
             100                 105                 110        
 Arg Asp Leu Ser His Lys Glu Lys Leu Tyr Leu Arg Glu Leu Asn Val
         115                 120                 125            
 Ile Thr Glu Thr Gln Cys Thr Leu Gly Leu Thr Ala Leu Arg Ser Asp
     130                 135                 140                
 Glu Val Ile Asp Leu Met Ile Lys Glu Tyr Pro Ala Lys His Ala Glu
 145                 150                 155                 160
 Tyr Ser Val Ile Leu Gln Glu Lys Glu Arg Gln Arg Ile Thr Asp His
                 165                 170                 175    
 Tyr Lys Glu Tyr Ser Gln Met Gln Gln Gln Asn Thr Gln Lys Val Glu
             180                 185                 190        
 Ala Ser Lys Val Pro Glu Tyr Ile Lys Lys Ala Ala Lys Lys Ala Ala
         195                 200                 205            
 Glu Phe Asn Ser Asn Leu Asn Arg Glu Arg Met Glu Glu Arg Arg Ala
     210                 215                 220                
 Tyr Phe Asp Leu Gln Thr His Val Ile Gln Val Pro Gln Gly Lys Tyr
 225                 230                 235                 240
 Lys Val Leu Pro Thr Glu Arg Thr Lys Val Ser Ser Tyr Pro Val Ala
                 245                 250                 255    
 Leu Ile Pro Gly Gln Phe Gln Glu Tyr Tyr Lys Arg Tyr Ser Pro Asp
             260                 265                 270        
 Glu Leu Arg Tyr Leu Pro Leu Asn Thr Ala Leu Tyr Glu Pro Pro Leu
         275                 280                 285            
 Asp Pro Glu Leu Pro Ala Leu Asp Ser Asp Gly Asp Ser Asp Asp Gly
     290                 295                 300                
 Glu Asp Gly Arg Gly Asp Glu Lys Arg Lys Asn Lys Gly Thr Ser Asp
 305                 310                 315                 320
 Ser Ser Ser Gly Asn Val Ser Glu Gly Glu Ser Pro Pro Asp Ser Gln
                 325                 330                 335    
 Glu Asp Ser Phe Gln Gly Arg Gln Lys Ser Lys Asp Lys Ala Ala Thr
             340                 345                 350        
 Pro Arg Lys Asp Gly Pro Lys Arg Ser Val Leu Ser Lys Ser Val Pro
         355                 360                 365            
 Gly Tyr Lys Pro Lys Val Ile Pro Asn Ala Ile Cys Gly Ile Cys Leu
     370                 375                 380                
 Lys Gly Lys Glu Ser Asn Lys Lys Gly Lys Ala Glu Ser Leu Ile His
 385                 390                 395                 400
 Cys Ser Gln Cys Glu Asn Ser Gly His Pro Ser Cys Leu Asp Met Thr
                 405                 410                 415    
 Met Glu Leu Val Ser Met Ile Lys Thr Tyr Pro Trp Gln Cys Met Glu
             420                 425                 430        
 Cys Lys Thr Cys Ile Ile Cys Gly Gln Pro His His Glu Glu Glu Met
         435                 440                 445            
 Met Phe Cys Asp Met Cys Asp Arg Gly Tyr His Thr Phe Cys Val Gly
     450                 455                 460                
 Leu Gly Ala Ile Pro Ser Gly Arg Trp Ile Cys Asp Cys Cys Gln Arg
 465                 470                 475                 480
 Ala Pro Pro Thr Pro Arg Lys Val Gly Arg Arg Gly Lys Asn Ser Lys
                 485                 490                 495    
 Glu Gly
        



      <210> 617
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 617
 Met Ala Gln Asp Phe Ser Gln His Pro Gln Thr Gly Ile Ile Arg Arg
   1               5                  10                  15    
 His Arg Phe Tyr Ser Pro Lys Pro Leu Ser Thr Thr Pro Arg Gly Gln
              20                  25                  30        
 Ser Phe Leu Leu Ser Arg Gln Ala Lys Val Ala Thr Trp Asp Pro Met
          35                  40                  45            
 Leu Ser Pro Asp Phe Gln Pro Lys Ser Ala Phe Lys Leu Thr Trp Thr
      50                  55                  60                
 Ala Gln Pro Pro Cys Leu Ser Val Thr Pro Ser Gln Gly Gln Thr Phe
  65                  70                  75                  80
 His Pro Asn Ser Pro Glu Gly Glu Leu Pro Pro Asp Leu Thr Glu Asn
                  85                  90                  95    
 Thr Cys Pro Ser Gln Ala
             100        



      <210> 618
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 618
 Met Glu Val Met Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg
   1               5                  10                  15    
 Arg Ala Asp Arg Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser
              20                  25                  30        
 Cys His Lys Lys Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr
          35                  40                  45            
 Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His
      50                  55                  60                
 Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg
  65                  70                  75                  80
 Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala
                  85                  90                  95    
 His Leu Gln Thr Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln
             100                 105                 110        
 Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro
         115                 120                 125            
 Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu
     130                 135                 140                
 Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala
 145                 150                 155                 160
 Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala
                 165                 170                 175    
 Asp Leu Lys Arg His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu
             180                 185                 190        
 Arg Lys Glu Asn Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys
         195                 200                 205            
 Gly Pro Ile Glu Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr
     210                 215                 220                
 Ser Glu Leu Trp Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser
 225                 230                 235                 240
 Ser Thr Trp Gln Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile
                 245                 250                 255    
 Pro Ile Pro Asn Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro
             260                 265                 270        
 Leu Met Glu Leu Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn
         275                 280                 285        



      <210> 619
      <211> 1002
      <212> PRT
      <213> Homo sapiens


      <400> 619
 Met His Asp Asn Asn Tyr Gly Cys Ile Lys Ser Ile Ala Asn Ser Phe
   1               5                  10                  15    
 Asp Asp Arg Phe Leu Val Thr Ala Gly Ala Asp Gly Asn Ile Phe Val
              20                  25                  30        
 Phe Asn Ile Phe Ser Glu Phe Met Leu Arg Lys Asp Met Lys Ala Lys
          35                  40                  45            
 Val Pro Ser Pro Arg Phe Gly Ile Glu Thr Glu Pro Ile Pro Glu Asp
      50                  55                  60                
 Ile Glu Asp Pro Lys Ala Tyr Ser Ile Glu Asn Ala Arg Arg Lys Arg
  65                  70                  75                  80
 Glu His Asp Lys Leu Met Lys Glu Val Gly Glu Ile Lys Ala Arg Lys
                  85                  90                  95    
 Arg Glu Gln Ile Lys Ala Leu Arg Ser Glu Phe Cys Asn Leu Leu Glu
             100                 105                 110        
 Met Asn Glu Lys Leu Pro Lys His Met Gln Phe Lys Arg Thr Asp Phe
         115                 120                 125            
 Asp Val Asp Ser Gln Ile Arg Ala Glu Met His Arg Lys Thr Ala Phe
     130                 135                 140                
 Lys Ile Gln Gln Val Glu Lys Glu Leu Ala Trp Glu Lys Glu Lys His
 145                 150                 155                 160
 Glu Leu Gly Leu Met Lys Leu Lys Asn Arg Phe Arg Asp Pro Leu Glu
                 165                 170                 175    
 Ser Asp Thr Ile Val Val His Ala Ile Leu Ser Asp His Lys Ile Ser
             180                 185                 190        
 Ser Tyr Arg Leu Val Gln Pro Ser Lys Tyr Ser Lys Phe Lys Arg Ala
         195                 200                 205            
 Ser Gln Ser Glu Arg Lys Pro Ser Lys Leu Asp Arg Phe Glu Lys Glu
     210                 215                 220                
 Gly Pro Gly Arg Lys Asp Ser Gln Arg Asp Ala Gly Gly Ser Val Thr
 225                 230                 235                 240
 Ile Gln Glu Glu Ser Ile Ile Glu Lys Gly Lys Lys Phe Arg Pro Lys
                 245                 250                 255    
 Thr Leu Ser Glu Ile Ile Val Glu Asn Gln Ile Glu Lys Thr Arg Lys
             260                 265                 270        
 Leu Ile Leu Lys Ala Glu Arg Ala Gln Leu Lys Ile Gln Gln Arg Lys
         275                 280                 285            
 Lys Glu Trp Glu Glu Leu Tyr Lys Ser Lys Pro Gly Asp Asp Tyr Glu
     290                 295                 300                
 Asp Pro Lys Asp Leu Gln Ala Ile Lys Glu Ala Gln Val Tyr Met Gly
 305                 310                 315                 320
 Asp Phe Asn Leu Lys Thr Ala Pro Asp Tyr Lys Ile Pro Glu His Met
                 325                 330                 335    
 Arg Ile Asn Ala Ala Lys Lys Glu Glu Glu Leu Gly His Leu Asp Ser
             340                 345                 350        
 Leu Val His Gly Asn Lys Arg His Met Asn Lys Cys Ile Leu Ser Leu
         355                 360                 365            
 Arg Asp Leu Lys Val Ala Val Val Glu Glu Ile Gln Cys Leu Val Gln
     370                 375                 380                
 Glu Leu Lys Asn Ile Gln Ser Thr Leu His Ile Ser Lys His Ile Pro
 385                 390                 395                 400
 Ile Pro Lys Ile Pro Gln Ile His Pro Glu Glu Val Pro Glu Lys Arg
                 405                 410                 415    
 Phe Gln Tyr Asp Glu Glu Thr Leu Leu Asn Phe Lys Gln Gln Gln Met
             420                 425                 430        
 Lys Ser Lys Asp Glu Lys Ser Pro Gly Val Glu Gln Thr Gly Ser Gly
         435                 440                 445            
 Gly Pro Val Gly Gly Phe Leu Lys Leu Ser Ser Arg Lys Asp Gly Asp
     450                 455                 460                
 Leu Thr Thr Arg Asp Ser Ile Ser Arg Ser Ser Lys Ala Ser Thr Phe
 465                 470                 475                 480
 Ser Leu Asp Ile Pro Lys Cys Leu Glu Phe Glu Lys Ala Glu Pro Thr
                 485                 490                 495    
 Asp Val Glu Leu Glu Ile Met Lys Arg Asp Glu Ile Lys His Val Tyr
             500                 505                 510        
 Met Gln Gln Tyr Leu Val Asn Arg Ile Lys Glu Leu Val Val Thr Phe
         515                 520                 525            
 Asp Ala Glu Leu Arg Leu Leu Arg His Gln Lys Leu Lys Leu Asp Thr
     530                 535                 540                
 Gln Met Lys Leu Ser Asp Leu His His Val Thr Leu Phe Gln Glu Ile
 545                 550                 555                 560
 Leu Leu Leu Lys Asn Phe Glu Lys Gln Glu Asn Ile Leu Gln Glu Arg
                 565                 570                 575    
 Val Asn Ser Leu Asp Lys Glu Glu Gln Tyr Met Gln Trp Lys Ile Asn
             580                 585                 590        
 Glu Thr Leu Lys Glu Met Glu Glu Lys Lys Asn Glu Ile Thr Lys Leu
         595                 600                 605            
 Gln Glu Gln Glu Lys Ala Leu Tyr Ala Gly Phe Gln Ala Ala Ile Gly
     610                 615                 620                
 Glu Asn Asn Lys Phe Ala Asn Phe Leu Met Lys Val Leu Lys Lys Lys
 625                 630                 635                 640
 Ile Lys Arg Val Lys Lys Lys Glu Val Glu Gly Asp Ala Asp Glu Asp
                 645                 650                 655    
 Glu Glu Ser Glu Glu Ser Ser Glu Glu Glu Ser Ser Leu Glu Ser Asp
             660                 665                 670        
 Glu Asp Glu Ser Glu Ser Glu Asp Glu Val Phe Asp Asp Ser Ile Cys
         675                 680                 685            
 Pro Thr Asn Cys Asp Val Ala Leu Phe Glu Leu Ala Leu His Leu Arg
     690                 695                 700                
 Glu Lys Arg Leu Asp Ile Glu Glu Ala Leu Val Glu Glu Lys Lys Ile
 705                 710                 715                 720
 Val Asp Asn Leu Lys Lys Glu Tyr Asp Thr Leu Ser Lys Lys Val Lys
                 725                 730                 735    
 Ile Val Ala Thr Asn Leu Asn Ala Ala Glu Glu Ala Leu Glu Ala Tyr
             740                 745                 750        
 Gln Arg Glu Lys Gln Gln Arg Leu Asn Glu Leu Leu Val Val Ile Pro
         755                 760                 765            
 Leu Lys Pro His Gln Ile Glu Tyr Val Val Phe Gly Glu Ile Pro Ser
     770                 775                 780                
 Asp Leu Ser Gly Thr Leu Val Phe Ser Asn His Ala Leu Arg Arg Leu
 785                 790                 795                 800
 Gln Glu Arg Ile Arg Glu Leu Gln Glu Glu Asn Ser Lys Gln Gln Lys
                 805                 810                 815    
 Leu Asn Lys Glu Trp Arg Glu Arg Arg Lys Gln Leu Ile Arg Glu Lys
             820                 825                 830        
 Arg Glu Met Thr Lys Thr Ile His Lys Met Glu Glu Thr Val Arg Gln
         835                 840                 845            
 Leu Met Ile Ser Lys Phe Gly Arg Val Val Asn Leu Glu Ala Leu Gln
     850                 855                 860                
 Met Leu Ser Val Asn Thr Thr Leu Glu Glu Leu Lys Ile Arg Lys Leu
 865                 870                 875                 880
 Arg Lys Glu Leu Ala Asn Ala Lys Glu Met Lys Met Trp Glu Glu Lys
                 885                 890                 895    
 Ile Ala Gln Met Arg Trp Glu Leu Met Met Lys Thr Lys Glu His Thr
             900                 905                 910        
 Arg Lys Leu Tyr Gln Met Asn Asp Leu Cys Ile Glu Lys Lys Lys Leu
         915                 920                 925            
 Asp Ser Arg Leu Asn Thr Leu Gln Asn Gln Gln Gly Asn Ala Phe Gln
     930                 935                 940                
 Gly Pro Arg Glu Ala Asp Val Val Ala Arg Glu Glu Val Thr Glu Leu
 945                 950                 955                 960
 Ile Gln Leu Gln Ala Glu Arg Ile Ser Ala Leu Lys Glu Glu Ile Ala
                 965                 970                 975    
 Leu Leu Arg Arg Lys Gly Gly Leu Ile Leu Pro Pro Ile Gln Ser Pro
             980                 985                 990        
 Arg Glu Lys Glu Ile Gln Pro Ala Asp Leu
         995                1000        



      <210> 620
      <211> 544
      <212> PRT
      <213> Homo sapiens


      <400> 620
 Met Glu Ala Trp Arg Cys Val Arg Lys Gly Tyr Gly His Cys Val Val
   1               5                  10                  15    
 Gly Arg Gly Arg Tyr Pro Met Phe Pro His His Ser Arg Ser Leu Gly
              20                  25                  30        
 Arg Asp Trp Thr Thr Pro Trp Glu Asn Leu Gln Arg Cys Cys Trp Asn
          35                  40                  45            
 Arg His Ile Ser Ser Cys Met Arg Trp Pro Gly His Tyr Ser Arg Ala
      50                  55                  60                
 Pro Tyr Pro Tyr Phe Ser Ser Arg His Phe Ser Leu Asn Trp Arg Pro
  65                  70                  75                  80
 Pro Cys Leu Phe Glu Ser Arg Thr Gln Phe Gln Tyr Cys Asn Trp Arg
                  85                  90                  95    
 Pro Asp Asn Leu Ser Gln Thr Ser Leu Ile His Leu Ser Ser Tyr Val
             100                 105                 110        
 Met Asn Ala Glu Gly Asp Glu Pro Ser Ser Lys Arg Arg Lys His Gln
         115                 120                 125            
 Gly Val Ile Lys Arg Asn Trp Glu Tyr Ile Cys Ser His Asp Lys Glu
     130                 135                 140                
 Lys Thr Lys Ile Leu Gly Asp Lys Asn Val Asp Pro Lys Cys Glu Asp
 145                 150                 155                 160
 Ser Glu Asn Lys Phe Asp Phe Ser Val Met Ser Tyr Asn Ile Leu Ser
                 165                 170                 175    
 Gln Asp Leu Leu Glu Asp Asn Ser His Leu Tyr Arg His Cys Arg Arg
             180                 185                 190        
 Pro Val Leu His Trp Ser Phe Arg Phe Pro Asn Ile Leu Lys Glu Ile
         195                 200                 205            
 Lys His Phe Asp Ala Asp Val Leu Cys Leu Gln Glu Val Gln Glu Asp
     210                 215                 220                
 His Tyr Gly Ala Glu Ile Arg Pro Ser Leu Glu Ser Leu Gly Tyr His
 225                 230                 235                 240
 Cys Glu Tyr Lys Met Arg Thr Gly Arg Lys Pro Asp Gly Cys Ala Ile
                 245                 250                 255    
 Cys Phe Lys His Ser Lys Phe Ser Leu Leu Ser Val Asn Pro Val Glu
             260                 265                 270        
 Phe Phe Arg Pro Asp Ile Ser Leu Leu Asp Arg Asp Asn Val Gly Leu
         275                 280                 285            
 Val Leu Leu Leu Gln Pro Lys Ile Pro Tyr Ala Ala Cys Pro Ala Ile
     290                 295                 300                
 Cys Val Ala Asn Thr His Leu Leu Tyr Asn Pro Arg Arg Gly Asp Ile
 305                 310                 315                 320
 Lys Leu Thr Gln Leu Ala Met Leu Leu Ala Glu Ile Ser Ser Val Ala
                 325                 330                 335    
 His Gln Lys Asp Gly Ser Phe Cys Pro Ile Val Met Cys Gly Asp Phe
             340                 345                 350        
 Asn Ser Val Pro Gly Ser Pro Leu Tyr Ser Phe Ile Lys Glu Gly Lys
         355                 360                 365            
 Leu Asn Tyr Glu Gly Leu Pro Ile Gly Lys Val Ser Gly Gln Glu Gln
     370                 375                 380                
 Ser Ser Arg Gly Gln Arg Ile Leu Ser Ile Pro Ile Trp Pro Pro Asn
 385                 390                 395                 400
 Leu Gly Ile Ser Gln Asn Cys Val Tyr Glu Val Gln Gln Val Pro Lys
                 405                 410                 415    
 Val Glu Lys Thr Asp Ser Asp Leu Thr Gln Thr Gln Leu Lys Gln Thr
             420                 425                 430        
 Glu Val Leu Val Thr Ala Glu Lys Leu Ser Ser Asn Leu Gln His His
         435                 440                 445            
 Phe Ser Leu Ala Ser Val Tyr Ser His Tyr Phe Pro Asp Thr Gly Ile
     450                 455                 460                
 Pro Glu Val Thr Thr Cys His Ser Arg Ser Ala Ile Thr Val Asp Tyr
 465                 470                 475                 480
 Ile Phe Tyr Ser Ala Glu Lys Glu Asp Val Ala Gly His Pro Gly Ala
                 485                 490                 495    
 Glu Val Ala Leu Val Gly Gly Leu Lys Leu Leu Ala Arg Leu Ser Leu
             500                 505                 510        
 Leu Thr Glu Gln Asp Leu Trp Thr Val Asn Gly Leu Pro Asn Glu Asn
         515                 520                 525            
 Asn Ser Ser Asp His Leu Pro Leu Leu Ala Lys Phe Arg Leu Glu Leu
     530                 535                 540                





      <210> 621
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 621
 Met Asp Leu Ile Ile Ser Thr Leu Asn Met Ser Lys Ile Gly Tyr Phe
   1               5                  10                  15    
 Tyr Thr Asp Cys Leu Val Pro Met Val Gly Asn Asn Pro Tyr Ala Thr
              20                  25                  30        
 Thr Glu Gly Asn Ser Thr Glu Leu Ser Ile Asn Ala Glu Val Tyr Ser
          35                  40                  45            
 Leu Pro Ser Arg Lys Leu Val Ala Leu Gln Leu Arg Ser Ile Phe Ile
      50                  55                  60                
 Lys Tyr Lys Ser Lys Pro Phe Cys Glu Lys Leu Leu Ser Trp Val Lys
  65                  70                  75                  80
 Ser Ser Gly Cys Ala Arg Val Ile Val Leu Ser Ser Ser His Ser Tyr
                  85                  90                  95    
 Gln Arg Asn Asp Leu Gln Leu Arg Ser Thr Pro Phe Arg Tyr Leu Leu
             100                 105                 110        
 Thr Pro Ser Met Gln Lys Ser Val Gln Asn Lys Ile Lys Ser Leu Asn
         115                 120                 125            
 Trp Glu Glu Met Glu Lys Ser Arg Cys Ile Pro Glu Ile Asp Asp Ser
     130                 135                 140                
 Glu Phe Cys Ile Arg Ile Pro Gly Gly Gly Ile Thr Lys Thr Leu Tyr
 145                 150                 155                 160
 Asp Glu Ser Cys Ser Lys Glu Ile Gln Met Ala Val Leu Leu Lys Phe
                 165                 170                 175    
 Val Ser Glu Gly Asp Asn Ile Pro Asp Ala Leu Gly Leu Val Glu Tyr
             180                 185                 190        
 Leu Asn Glu Trp Leu Gln Ile Leu Lys Pro Leu Ser Asp Asp Pro Thr
         195                 200                 205            
 Val Ser Ala Ser Arg Trp Lys Ile Pro Ser Ser Trp Arg Leu Leu Phe
     210                 215                 220                
 Gly Ser Gly Leu Pro Pro Ala Leu Phe
 225                 230            



      <210> 622
      <211> 591
      <212> PRT
      <213> Homo sapiens


      <400> 622
 Met Asp Asp Phe Arg Asp Pro Gln Arg Trp Lys Glu Cys Ala Lys Gln
   1               5                  10                  15    
 Gly Lys Met Pro Cys Tyr Phe Asp Leu Ile Glu Glu Asn Val Tyr Leu
              20                  25                  30        
 Thr Glu Arg Lys Lys Asn Lys Ser His Arg Asp Ile Lys Arg Met Gln
          35                  40                  45            
 Cys Glu Cys Thr Pro Leu Ser Lys Asp Glu Arg Ala Gln Gly Glu Ile
      50                  55                  60                
 Ala Cys Gly Glu Asp Cys Leu Asn Arg Leu Leu Met Ile Glu Cys Ser
  65                  70                  75                  80
 Ser Arg Cys Pro Asn Gly Asp Tyr Cys Ser Asn Arg Arg Phe Gln Arg
                  85                  90                  95    
 Lys Gln His Ala Asp Val Glu Val Ile Leu Thr Glu Lys Lys Gly Trp
             100                 105                 110        
 Gly Leu Arg Ala Ala Lys Asp Leu Pro Ser Asn Thr Phe Val Leu Glu
         115                 120                 125            
 Tyr Cys Gly Glu Val Leu Asp His Lys Glu Phe Lys Ala Arg Val Lys
     130                 135                 140                
 Glu Tyr Ala Arg Asn Lys Asn Ile His Tyr Tyr Phe Met Ala Leu Lys
 145                 150                 155                 160
 Asn Asp Glu Ile Ile Asp Ala Thr Gln Lys Gly Asn Cys Ser Arg Phe
                 165                 170                 175    
 Met Asn His Ser Cys Glu Pro Asn Cys Glu Thr Gln Lys Trp Thr Val
             180                 185                 190        
 Asn Gly Gln Leu Arg Val Gly Phe Phe Thr Thr Lys Leu Val Pro Ser
         195                 200                 205            
 Gly Ser Glu Leu Thr Phe Asp Tyr Gln Phe Gln Arg Tyr Gly Lys Glu
     210                 215                 220                
 Ala Gln Lys Cys Phe Cys Gly Ser Ala Asn Cys Arg Gly Tyr Leu Gly
 225                 230                 235                 240
 Gly Glu Asn Arg Val Ser Ile Arg Ala Ala Gly Gly Lys Met Lys Lys
                 245                 250                 255    
 Glu Arg Ser Arg Lys Lys Asp Ser Val Asp Gly Glu Leu Glu Ala Leu
             260                 265                 270        
 Met Glu Asn Gly Glu Gly Leu Ser Asp Lys Asn Gln Val Leu Ser Leu
         275                 280                 285            
 Ser Arg Leu Met Val Arg Ile Glu Thr Leu Glu Gln Lys Leu Thr Cys
     290                 295                 300                
 Leu Glu Leu Ile Gln Asn Thr His Ser Gln Ser Cys Leu Lys Ser Phe
 305                 310                 315                 320
 Leu Glu Arg His Gly Leu Ser Leu Leu Trp Ile Trp Met Ala Glu Leu
                 325                 330                 335    
 Gly Asp Gly Arg Glu Ser Asn Gln Lys Leu Gln Glu Glu Ile Ile Lys
             340                 345                 350        
 Thr Leu Glu His Leu Pro Ile Pro Thr Lys Asn Met Leu Glu Glu Ser
         355                 360                 365            
 Lys Val Leu Pro Ile Ile Gln Arg Trp Ser Gln Thr Lys Thr Ala Val
     370                 375                 380                
 Pro Pro Leu Ser Glu Gly Asp Gly Tyr Ser Ser Glu Asn Thr Ser Arg
 385                 390                 395                 400
 Ala His Thr Pro Leu Asn Thr Pro Asp Pro Ser Thr Lys Leu Ser Thr
                 405                 410                 415    
 Glu Ala Asp Thr Asp Thr Pro Lys Lys Leu Met Phe Arg Arg Leu Lys
             420                 425                 430        
 Ile Ile Ser Glu Asn Ser Met Asp Ser Ala Ile Ser Asp Ala Thr Ser
         435                 440                 445            
 Glu Leu Glu Gly Lys Gly Trp Gln Glu Asp Leu Asp Gln Leu Glu Asn
     450                 455                 460                
 Val Pro Val Glu Glu Glu Glu Glu Leu Gln Ser Gln Gln Leu Leu Pro
 465                 470                 475                 480
 Gln Gln Leu Pro Glu Cys Lys Val Asp Ser Glu Thr Asn Ile Glu Ala
                 485                 490                 495    
 Ser Lys Leu Pro Thr Ser Glu Pro Glu Ala Asp Ala Glu Ile Glu Pro
             500                 505                 510        
 Lys Glu Ser Asn Gly Thr Lys Leu Glu Glu Pro Ile Asn Glu Glu Thr
         515                 520                 525            
 Pro Ser Gln Asp Glu Glu Glu Gly Val Ser Asp Val Glu Ser Glu Arg
     530                 535                 540                
 Ser Gln Glu Gln Pro Asp Lys Thr Val Asp Ile Ser Asp Leu Ala Thr
 545                 550                 555                 560
 Lys Leu Leu Asp Ser Trp Lys Asp Leu Lys Glu Val Tyr Arg Ile Pro
                 565                 570                 575    
 Lys Lys Ser Gln Thr Glu Lys Glu Asn Thr Arg Asn Gln Pro Glu
             580                 585                 590    



      <210> 623
      <211> 304
      <212> PRT
      <213> Homo sapiens


      <400> 623
 Met Ala Glu Ala Ser Ala Ala Gly Ala Asp Ser Gly Ala Ala Val Ala
   1               5                  10                  15    
 Ala His Arg Phe Phe Cys His Phe Cys Lys Gly Glu Val Ser Pro Lys
              20                  25                  30        
 Leu Pro Glu Tyr Ile Cys Pro Arg Cys Glu Ser Gly Phe Ile Glu Glu
          35                  40                  45            
 Val Thr Asp Asp Ser Ser Phe Leu Gly Gly Gly Gly Ser Arg Ile Asp
      50                  55                  60                
 Asn Thr Thr Thr Thr His Phe Ala Glu Leu Trp Gly His Leu Asp His
  65                  70                  75                  80
 Thr Met Phe Phe Gln Asp Phe Arg Pro Phe Leu Ser Ser Ser Pro Leu
                  85                  90                  95    
 Asp Gln Asp Asn Arg Ala Asn Glu Arg Gly His Gln Thr His Thr Asp
             100                 105                 110        
 Phe Trp Gly Ala Arg Pro Pro Arg Leu Pro Leu Gly Arg Arg Tyr Arg
         115                 120                 125            
 Ser Arg Gly Ser Ser Arg Pro Asp Arg Ser Pro Ala Ile Glu Gly Ile
     130                 135                 140                
 Leu Gln His Ile Phe Ala Gly Phe Phe Ala Asn Ser Ala Ile Pro Gly
 145                 150                 155                 160
 Ser Pro His Pro Phe Ser Trp Ser Gly Met Leu His Ser Asn Pro Gly
                 165                 170                 175    
 Asp Tyr Ala Trp Gly Gln Thr Gly Leu Asp Ala Ile Val Thr Gln Leu
             180                 185                 190        
 Leu Gly Gln Leu Glu Asn Thr Gly Pro Pro Pro Ala Asp Lys Glu Lys
         195                 200                 205            
 Ile Thr Ser Leu Pro Thr Val Thr Val Thr Gln Glu Gln Val Asp Met
     210                 215                 220                
 Gly Leu Glu Cys Pro Val Cys Lys Glu Asp Tyr Thr Val Glu Glu Glu
 225                 230                 235                 240
 Val Arg Gln Leu Pro Cys Asn His Phe Phe His Ser Ser Cys Ile Val
                 245                 250                 255    
 Pro Trp Leu Glu Leu His Asp Thr Cys Pro Val Cys Arg Lys Ser Leu
             260                 265                 270        
 Asn Gly Glu Asp Ser Thr Arg Gln Ser Gln Ser Thr Glu Ala Ser Ala
         275                 280                 285            
 Ser Asn Arg Phe Ser Asn Asp Ser Gln Leu His Asp Arg Trp Thr Phe
     290                 295                 300                





      <210> 624
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 624
 Met Glu Ser Gly Val Tyr Tyr Thr Arg Gly Arg Glu Glu Val Thr Arg
   1               5                  10                  15    
 Ser Ser Gly Gly Arg Ser Val Gly Leu Ser His Val Val Lys Ala His
              20                  25                  30        
 Gly Val Ser Ala Arg Ala Leu Cys Asp Trp Lys Asn Thr Ala Ser Trp
          35                  40                  45            
 Ser Ser Pro Pro Pro Leu Ser Pro Trp Ser Ser Cys Lys Ser Ala Arg
      50                  55                  60                
 Met Ser Gln Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His Leu
  65                  70                  75                  80
 Lys Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His Tyr
                  85                  90                  95    
 Lys Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met Leu
             100                 105                 110        
 Asp Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys Gly
         115                 120                 125            
 Thr Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu Glu
     130                 135                 140                
 Leu Lys Lys Lys Tyr Gly Ile
 145                 150    



      <210> 625
      <211> 366
      <212> PRT
      <213> Homo sapiens


      <400> 625
 Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg
   1               5                  10                  15    
 Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu
              20                  25                  30        
 Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys
          35                  40                  45            
 Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr
      50                  55                  60                
 Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu
  65                  70                  75                  80
 Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu
                  85                  90                  95    
 Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser
             100                 105                 110        
 Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr
         115                 120                 125            
 Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val
     130                 135                 140                
 Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile
 145                 150                 155                 160
 Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro
                 165                 170                 175    
 Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu
             180                 185                 190        
 Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly
         195                 200                 205            
 Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro
     210                 215                 220                
 Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser
 225                 230                 235                 240
 Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe
                 245                 250                 255    
 Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro
             260                 265                 270        
 Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Val Asp Asp Ile
         275                 280                 285            
 Asn Ala Asp Lys Asn Ile Ser Ser Ala Gln Ile Val Gly Pro Gly Pro
     290                 295                 300                
 Lys Pro Glu Ala Ser Ala Lys Leu Pro Ser Arg Pro Ala Asp Asn Tyr
 305                 310                 315                 320
 Asp Asn Phe Val Leu Pro Glu Leu Pro Ser Val Pro Asp Thr Leu Pro
                 325                 330                 335    
 Thr Ala Ser Ala Gly Ala Ser Thr Ser Ala Ser Glu Asp Ile Asp Phe
             340                 345                 350        
 Asp Asp Leu Ser Arg Arg Phe Glu Glu Leu Lys Lys Lys Thr
         355                 360                 365    



      <210> 626
      <211> 481
      <212> PRT
      <213> Homo sapiens


      <400> 626
 Met Arg Gly Leu Pro Arg Lys Arg Glu Ala Trp Thr Gln Pro His Pro
   1               5                  10                  15    
 Leu Glu Ala Leu Tyr Glu Ser Leu Arg Val Leu Glu Lys Asp Thr Ser
              20                  25                  30        
 Ala Thr Ser Gln Ser Val Asn Gly Ser Pro Gln Ala Glu Gln Pro Ser
          35                  40                  45            
 Leu Glu Ser Thr Ser Lys Glu Ala Phe Phe Ser Arg Val Glu Thr Phe
      50                  55                  60                
 Ser Ser Leu Lys Trp Ala Gly Lys Pro Phe Glu Leu Ser Pro Leu Val
  65                  70                  75                  80
 Cys Ala Lys Tyr Gly Trp Val Thr Val Glu Cys Asp Met Leu Lys Cys
                  85                  90                  95    
 Ser Ser Cys Gln Ala Phe Leu Cys Ala Ser Leu Gln Pro Ala Phe Asp
             100                 105                 110        
 Phe Asp Arg Tyr Lys Gln Arg Cys Ala Glu Leu Lys Lys Ala Leu Cys
         115                 120                 125            
 Thr Ala His Glu Lys Phe Cys Phe Trp Pro Asp Ser Pro Ser Pro Asp
     130                 135                 140                
 Arg Phe Gly Met Leu Pro Leu Asp Glu Pro Ala Ile Leu Val Ser Glu
 145                 150                 155                 160
 Phe Leu Asp Arg Phe Gln Ser Leu Cys His Leu Asp Leu Gln Leu Pro
                 165                 170                 175    
 Ser Leu Arg Pro Glu Asp Leu Lys Thr Met Cys Leu Thr Glu Asp Lys
             180                 185                 190        
 Ile Ser Leu Leu Leu His Leu Leu Glu Asp Glu Leu Asp His Arg Thr
         195                 200                 205            
 Asp Glu Arg Lys Thr Thr Ile Lys Leu Gly Ser Asp Ile Gln Val His
     210                 215                 220                
 Val Thr Ala Cys Ile Leu Ser Val Cys Gly Trp Ala Cys Ser Ser Ser
 225                 230                 235                 240
 Leu Glu Ser Met Gln Leu Ser Leu Ile Ala Cys Ser Gln Cys Met Arg
                 245                 250                 255    
 Lys Val Gly Leu Trp Gly Phe Gln Gln Ile Glu Ser Ser Met Thr Asp
             260                 265                 270        
 Leu Asp Ala Ser Phe Gly Leu Thr Ser Ser Pro Ile Pro Gly Leu Glu
         275                 280                 285            
 Gly Arg Pro Glu Arg Leu Pro Leu Val Pro Glu Ser Pro Arg Arg Met
     290                 295                 300                
 Met Thr Arg Ser Gln Asp Ala Thr Phe Ser Pro Gly Ser Glu Gln Ala
 305                 310                 315                 320
 Glu Lys Ser Pro Gly Pro Ile Val Ser Arg Thr Arg Ser Trp Asp Ser
                 325                 330                 335    
 Ser Ser Pro Val Asp Arg Pro Glu Pro Glu Ala Ala Ser Pro Thr Thr
             340                 345                 350        
 Arg Thr Arg Pro Val Thr Arg Ser Met Gly Thr Gly Asp Thr Pro Gly
         355                 360                 365            
 Leu Glu Val Pro Ser Ser Pro Leu Arg Lys Ala Lys Arg Ala Arg Leu
     370                 375                 380                
 Cys Ser Ser Ser Ser Ser Asp Thr Ser Ser Arg Ser Phe Phe Asp Pro
 385                 390                 395                 400
 Thr Ser Gln His Arg Asp Trp Cys Pro Trp Val Asn Ile Thr Leu Gly
                 405                 410                 415    
 Lys Glu Ser Arg Glu Asn Gly Gly Thr Glu Pro Asp Ala Ser Ala Pro
             420                 425                 430        
 Ala Glu Pro Gly Trp Lys Ala Val Leu Thr Ile Leu Leu Ala His Lys
         435                 440                 445            
 Gln Ser Ser Gln Pro Ala Glu Thr Asp Ser Met Ser Leu Ser Glu Lys
     450                 455                 460                
 Ser Arg Lys Val Phe Arg Ile Phe Arg Gln Trp Glu Ser Leu Cys Ser
 465                 470                 475                 480
 Cys
    



      <210> 627
      <211> 1308
      <212> PRT
      <213> Homo sapiens


      <400> 627
 Met Pro Glu Met Ser Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Ile
   1               5                  10                  15    
 Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Thr
              20                  25                  30        
 Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile Lys
          35                  40                  45            
 Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly Pro
      50                  55                  60                
 Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser Met
  65                  70                  75                  80
 Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys
                  85                  90                  95    
 Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp
             100                 105                 110        
 Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys
         115                 120                 125            
 Met Pro Glu Met Ser Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Ile
     130                 135                 140                
 Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Thr
 145                 150                 155                 160
 Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile Lys
                 165                 170                 175    
 Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly Pro
             180                 185                 190        
 Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser Met
         195                 200                 205            
 Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Ser Leu Pro Lys
     210                 215                 220                
 Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Asp Ile Pro Asp
 225                 230                 235                 240
 Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys
                 245                 250                 255    
 Met Pro Glu Ile Asn Ile Lys Ala Pro Lys Ile Ser Ile Pro Asp Val
             260                 265                 270        
 Asp Leu Asp Leu Lys Gly Pro Lys Val Lys Gly Asp Phe Asp Val Ser
         275                 280                 285            
 Val Pro Lys Val Glu Gly Thr Leu Lys Gly Pro Glu Val Asp Leu Lys
     290                 295                 300                
 Gly Pro Arg Leu Asp Phe Glu Gly Pro Asp Ala Lys Leu Ser Gly Pro
 305                 310                 315                 320
 Ser Leu Lys Met Pro Ser Leu Glu Ile Ser Ala Pro Lys Val Thr Ala
                 325                 330                 335    
 Pro Asp Val Asp Leu His Leu Lys Ala Pro Lys Ile Gly Phe Ser Gly
             340                 345                 350        
 Pro Lys Leu Glu Gly Gly Glu Val Asp Leu Lys Gly Pro Lys Val Glu
         355                 360                 365            
 Ala Pro Ser Leu Asp Val His Met Asp Ser Pro Asp Ile Asn Ile Glu
     370                 375                 380                
 Gly Pro Asp Val Lys Ile Pro Lys Phe Lys Lys Pro Lys Phe Gly Phe
 385                 390                 395                 400
 Gly Pro Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro Ser Leu Asp Val
                 405                 410                 415    
 Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro Glu Ile Ser Val
             420                 425                 430        
 Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro Lys Ile His Met
         435                 440                 445            
 Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe Asp Leu Asn Val
     450                 455                 460                
 Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro Asp Val Asp Val
 465                 470                 475                 480
 Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val Asp Val Lys Ser Pro
                 485                 490                 495    
 Lys Thr Lys Lys Thr Met Phe Gly Lys Met Tyr Phe Pro Asp Val Glu
             500                 505                 510        
 Phe Asp Ile Lys Ser Pro Lys Phe Lys Ala Glu Ala Pro Leu Pro Ser
         515                 520                 525            
 Pro Lys Leu Glu Gly Glu Leu Gln Ala Pro Asp Leu Glu Leu Ser Leu
     530                 535                 540                
 Pro Ala Ile His Val Glu Gly Leu Asp Ile Lys Ala Lys Ala Pro Lys
 545                 550                 555                 560
 Val Lys Met Pro Asp Val Asp Ile Ser Val Pro Lys Ile Glu Gly Asp
                 565                 570                 575    
 Leu Lys Gly Pro Lys Val Gln Ala Asn Leu Gly Ala Pro Asp Ile Asn
             580                 585                 590        
 Ile Glu Gly Leu Asp Ala Lys Val Lys Thr Pro Ser Phe Gly Ile Ser
         595                 600                 605            
 Ala Pro Gln Val Ser Ile Pro Asp Val Asn Val Asn Leu Lys Gly Pro
     610                 615                 620                
 Lys Ile Lys Gly Asp Val Pro Ser Val Gly Leu Glu Gly Pro Asp Val
 625                 630                 635                 640
 Asp Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro Lys Phe Ser Met
                 645                 650                 655    
 Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly Gly Gly Ala Glu
             660                 665                 670        
 Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu Arg Gly Pro Asp
         675                 680                 685            
 Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly Pro Gly Val Asp
     690                 695                 700                
 Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser Gly Pro Asp Leu
 705                 710                 715                 720
 Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly Asp Leu Asp Ala Ser
                 725                 730                 735    
 Val Pro Ser Met Lys Val His Ala Pro Gly Leu Asn Leu Ser Gly Val
             740                 745                 750        
 Gly Gly Lys Met Gln Val Gly Gly Asp Gly Val Lys Val Pro Gly Ile
         755                 760                 765            
 Asp Ala Thr Thr Lys Leu Asn Val Gly Ala Pro Asp Val Thr Leu Arg
     770                 775                 780                
 Gly Pro Ser Leu Gln Gly Asp Leu Ala Val Ser Gly Asp Ile Lys Cys
 785                 790                 795                 800
 Pro Lys Val Ser Val Gly Ala Pro Asp Leu Ser Leu Glu Ala Ser Glu
                 805                 810                 815    
 Gly Ser Ile Lys Leu Pro Lys Met Lys Leu Pro Gln Phe Gly Ile Ser
             820                 825                 830        
 Thr Pro Gly Ser Asp Leu His Val Asn Ala Lys Gly Pro Gln Val Ser
         835                 840                 845            
 Gly Glu Leu Lys Gly Pro Gly Val Asp Val Asn Leu Lys Gly Pro Arg
     850                 855                 860                
 Ile Ser Ala Pro Asn Val Asp Phe Asn Leu Glu Gly Pro Lys Val Lys
 865                 870                 875                 880
 Gly Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro Thr Val Gly Gly
                 885                 890                 895    
 Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly Asn Leu Gln Met
             900                 905                 910        
 Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu Pro Gly Val Asn
         915                 920                 925            
 Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu Ile Lys Gly Gly
     930                 935                 940                
 Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala Pro Asp Ile Ser
 945                 950                 955                 960
 Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro Glu Ser Asp Phe Gly
                 965                 970                 975    
 Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly Gly Ala Asp Val Ser Gly
             980                 985                 990        
 Gly Val Ser Ala Pro Asp Ile Ser Leu Gly Glu Gly His Leu Ser Val
         995                1000                1005            
 Lys Gly Ser Gly Gly Glu Trp Lys Gly Pro Gln Val Ser Ser Ala Leu
    1010                1015                1020                
 Asn Leu Asp Thr Ser Lys Phe Ala Gly Gly Leu His Phe Ser Gly Pro
1025                1030                1035                1040
 Lys Val Glu Gly Gly Val Lys Gly Gly Gln Ile Gly Leu Gln Ala Pro
                1045                1050                1055    
 Gly Leu Ser Val Ser Gly Pro Gln Gly His Leu Glu Ser Gly Ser Gly
            1060                1065                1070        
 Lys Val Thr Phe Pro Lys Met Lys Ile Pro Lys Phe Thr Phe Ser Gly
        1075                1080                1085            
 Arg Glu Leu Val Gly Arg Glu Met Gly Val Asp Val His Phe Pro Lys
    1090                1095                1100                
 Ala Glu Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly Glu Trp Glu Glu
1105                1110                1115                1120
 Ser Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met Pro Lys Phe Asn
                1125                1130                1135    
 Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly Ser Pro Glu Ala
            1140                1145                1150        
 Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser Lys Ala Ser Leu
        1155                1160                1165            
 Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser Ser Pro Lys Gly
    1170                1175                1180                
 Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His Arg Ser Asn Ser
1185                1190                1195                1200
 Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser Thr Pro Thr Gly Thr
                1205                1210                1215    
 Leu Glu Phe Glu Gly Gly Glu Val Ser Leu Glu Gly Gly Lys Val Lys
            1220                1225                1230        
 Gly Lys His Gly Lys Leu Lys Phe Gly Thr Phe Gly Gly Leu Gly Ser
        1235                1240                1245            
 Lys Ser Lys Gly His Tyr Glu Val Thr Gly Ser Asp Asp Glu Thr Gly
    1250                1255                1260                
 Lys Leu Gln Gly Ser Gly Val Ser Leu Ala Ser Lys Lys Ser Arg Leu
1265                1270                1275                1280
 Ser Ser Ser Ser Ser Asn Asp Ser Gly Asn Lys Val Gly Ile Gln Leu
                1285                1290                1295    
 Pro Glu Val Glu Leu Ser Val Ser Thr Lys Lys Glu
            1300                1305            



      <210> 628
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 628
 Met Arg Asp Asn Arg Ala Val Ser Leu Cys Gln Gln Glu Trp Met Cys
   1               5                  10                  15    
 Pro Gly Pro Ala Gln Arg Ala Leu Tyr Arg Gly Ala Thr Gln Arg Lys
              20                  25                  30        
 Asp Ser His Val Ser Leu Ala Thr Gly Val Pro Trp Gly Tyr Glu Glu
          35                  40                  45            
 Thr Lys Thr Leu Leu Ala Ile Leu Ser Ser Ser Gln Phe Tyr Gly Lys
      50                  55                  60                
 Leu Gln Thr Cys Gln Gln Asn Ser Gln Ile Tyr Arg Ala Met Ala Glu
  65                  70                  75                  80
 Gly Leu Trp Glu Gln Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg Thr
                  85                  90                  95    
 Lys Phe Lys Ser Leu Gln Leu Ser Tyr Arg Lys Val Arg Arg Gly Arg
             100                 105                 110        
 Val Pro Glu Pro Cys Ile Phe His Glu Glu Met Asn Ala Leu Ser Gly
         115                 120                 125            
 Ser Trp Ala Ser Ala Pro Pro Met Ala Ser Asp Ala Val Pro Gly Gln
     130                 135                 140                
 Glu Gly Ser Asp Ile Glu Ala Gly Glu Leu Asn His Gln Asn Gly Glu
 145                 150                 155                 160
 Pro Thr Glu Val Glu Asp Gly Thr Val Asp Gly Ala Asp Arg Asp Glu
                 165                 170                 175    
 Lys Asp Phe Arg Asn Pro Gly Gln Glu Val Arg Lys Leu Asp Leu Pro
             180                 185                 190        
 Val Leu Phe Pro Asn Arg Leu Gly Phe Glu Phe Lys Asn Glu Ile Lys
         195                 200                 205            
 Lys Glu Asn Leu Lys Trp Asp Asp Ser Glu Glu Val Glu Ile Asn Lys
     210                 215                 220                
 Ala Leu Gln Arg Lys Ser Arg Gly Val Tyr Trp His Ser Glu Leu Gln
 225                 230                 235                 240
 Lys Gly Leu Glu Ser Glu Pro Thr Ser Arg Arg Gln Cys Arg Asn Ser
                 245                 250                 255    
 Pro Gly Glu Ser Glu Glu Lys Thr Pro Ser Gln Glu Lys Met Ser His
             260                 265                 270        
 Gln Ser Phe Cys Ala Arg Asp Lys Ala Cys Thr His Ile Leu Cys Gly
         275                 280                 285            
 Lys Asn Cys Ser Gln Ser Val His Ser Pro His Lys Pro Ala Leu Lys
     290                 295                 300                
 Leu Glu Lys Val Ser Gln Cys Pro Glu Cys Gly Lys Thr Phe Ser Arg
 305                 310                 315                 320
 Ser Ser Tyr Leu Val Arg His Gln Arg Ile His Thr Gly Glu Lys Pro
                 325                 330                 335    
 His Lys Cys Ser Glu Cys Gly Lys Gly Phe Ser Glu Arg Ser Asn Leu
             340                 345                 350        
 Thr Ala His Leu Arg Thr His Thr Gly Glu Arg Pro Tyr Gln Cys Gly
         355                 360                 365            
 Gln Cys Gly Lys Ser Phe Asn Gln Ser Ser Ser Leu Ile Val His Gln
     370                 375                 380                
 Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Ile Val Cys Gly Lys
 385                 390                 395                 400
 Arg Phe Asn Asn Ser Ser Gln Phe Ser Ala His Arg Arg Ile His Thr
                 405                 410                 415    
 Gly Glu Ser Pro Tyr Lys Cys Ala Val Cys Gly Lys Ile Phe Asn Asn
             420                 425                 430        
 Ser Ser His Phe Ser Ala His Arg Lys Thr His Thr Gly Glu Lys Pro
         435                 440                 445            
 Tyr Arg Cys Ser His Cys Glu Arg Gly Phe Thr Lys Asn Ser Ala Leu
     450                 455                 460                
 Thr Arg His Gln Thr Val His Met Lys Ala Val Leu Ser Ser Gln Glu
 465                 470                 475                 480
 Gly Arg Asp Ala Leu
                 485



      <210> 629
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 629
 Met Glu Thr Met Asn Ser Ser Trp Val Ser Glu Pro Cys Gly Ser Gly
   1               5                  10                  15    
 Gly Met Leu Gly Leu Leu Ala Ser Glu Gly Trp Asp Ala Gly Pro Gly
              20                  25                  30        
 His Cys Ser Pro Ser Arg Pro Asp Gly Cys Ser Trp Gly Pro Gly Thr
          35                  40                  45            
 Tyr Ser Pro Ala Trp Ser Ile Arg Glu Arg Asn Gly Pro Asn Arg Gln
      50                  55                  60                
 Thr Met Gly Ala Pro Ala Thr Arg Arg Cys Val Glu Trp Leu Leu Gly
  65                  70                  75                  80
 Leu Tyr Phe Leu Ser His Ile Pro Ile Thr Leu Phe Met Asp Leu Gln
                  85                  90                  95    
 Ala Val Leu Pro Arg Glu Leu Tyr Pro Val Glu Phe Arg Asn Leu Leu
             100                 105                 110        
 Lys Trp Tyr Ala Lys Glu Phe Lys Asp Pro Leu Leu Gln Glu Pro Pro
         115                 120                 125            
 Ala Trp Phe Lys Ser Phe Leu Phe Cys Glu Leu Val Phe Gln Leu Pro
     130                 135                 140                
 Phe Phe Pro Ile Ala Thr Tyr Ala Phe Leu Lys Gly Ser Cys Lys Trp
 145                 150                 155                 160
 Ile Arg Thr Pro Ala Ile Ile Tyr Ser Val His Thr Met Thr Thr Leu
                 165                 170                 175    
 Ile Pro Ile Leu Ser Thr Phe Leu Phe Glu Asp Phe Ser Lys Ala Ser
             180                 185                 190        
 Gly Phe Lys Gly Gln Arg Pro Glu Thr Leu His Glu Arg Leu Thr Leu
         195                 200                 205            
 Val Ser Val Tyr Ala Pro Tyr Leu Leu Ile Pro Phe Ile Leu Leu Ile
     210                 215                 220                
 Phe Met Leu Arg Ser Pro Tyr Tyr Lys Tyr Glu Glu Lys Arg Lys Lys
 225                 230                 235                 240
 Lys
    



      <210> 630
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 630
 Met Gly Gln Pro Gln Trp Pro Pro Glu Leu Cys Glu Gln Val Thr Gly
   1               5                  10                  15    
 Asp Phe Asp Thr Glu Ala Gly Ala Val Ser Ser Ser Glu Pro Thr Val
              20                  25                  30        
 Ala Arg Asp Glu Pro Glu Ser Leu Ala Leu Ala Gln Lys Ser Pro Ala
          35                  40                  45            
 Pro Lys Val Arg Lys Pro Gly Arg Lys Pro Pro Thr Pro Gly Pro Glu
      50                  55                  60                
 Lys Ala Glu Ala Ala Ala Gly Glu Glu Ser Cys Gly Ala Ser Pro Thr
  65                  70                  75                  80
 Pro Ala Thr Ser Ala Ser Pro Pro Gly Pro Thr Leu Lys Ala Arg Phe
                  85                  90                  95    
 Arg Ser Leu Leu Glu Thr Ala Trp Leu Asn Gly Leu Ala Leu Pro Thr
             100                 105                 110        
 Trp Gly His Lys Ser Ser Arg Pro Asp Gln Pro Ser Pro Cys Pro Gln
         115                 120                 125            
 Leu Leu Asp Ser Gln Ser His His Leu
     130                 135        



      <210> 631
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 631
 Met Gly Gly Arg Lys Arg Glu Arg Lys Ala Ala Val Glu Glu Asp Thr
   1               5                  10                  15    
 Ser Leu Ser Glu Ser Glu Gly Pro Arg Gln Pro Asp Gly Asp Glu Glu
              20                  25                  30        
 Glu Ser Thr Ala Leu Ser Ile Asn Glu Glu Met Gln Arg Met Leu Asn
          35                  40                  45            
 Gln Leu Arg Glu Tyr Asp Phe Glu Asp Asp Cys Asp Ser Leu Thr Trp
      50                  55                  60                
 Glu Glu Thr Glu Glu Thr Leu Leu Leu Trp Glu Asp Phe Ser Gly Tyr
  65                  70                  75                  80
 Ala Met Ala Ala Ala Glu Ala Gln Gly Glu Gln Gln Glu Asp Ser Leu
                  85                  90                  95    
 Glu Lys Val Ile Lys Asp Thr Glu Ser Leu Phe Lys Thr Arg Glu Lys
             100                 105                 110        
 Glu Tyr Gln Glu Thr Ile Asp Gln Ile Glu Leu Glu Leu Ala Thr Ala
         115                 120                 125            
 Lys Asn Asp Met Asn Arg His Leu His Glu Tyr Met Glu Met Cys Ser
     130                 135                 140                
 Met Lys Arg Gly Leu Asp Val Gln Met Glu Thr Cys Arg Arg Leu Ile
 145                 150                 155                 160
 Thr Gln Ser Gly Asp Arg Lys Ser Pro Ala Phe Thr Ala Val Pro Leu
                 165                 170                 175    
 Ser Asp Pro Pro Pro Pro Pro Ser Glu Ala Glu Asp Ser Asp Arg Asp
             180                 185                 190        
 Val Ser Ser Asp Ser Ser Met Arg
         195                 200



      <210> 632
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 632
 Met Ala Leu Gly Leu Lys Cys Phe Arg Met Val His Pro Thr Phe Arg
   1               5                  10                  15    
 Asn Tyr Leu Ala Ala Ser Ile Arg Pro Val Ser Glu Val Thr Leu Lys
              20                  25                  30        
 Thr Val His Glu Arg Gln His Gly His Arg Gln Tyr Met Ala Tyr Ser
          35                  40                  45            
 Ala Val Pro Val Arg His Phe Ala Thr Lys Lys Ala Lys Ala Lys Gly
      50                  55                  60                
 Lys Gly Gln Ser Gln Thr Arg Val Asn Ile Asn Ala Ala Leu Val Glu
  65                  70                  75                  80
 Asp Ile Ile Asn Leu Glu Glu Val Asn Glu Glu Met Lys Ser Val Ile
                  85                  90                  95    
 Glu Ala Leu Lys Asp Asn Phe Asn Lys Thr Leu Asn Ile Arg Thr Ser
             100                 105                 110        
 Pro Gly Ser Leu Asp Lys Ile Ala Val Val Thr Ala Asp Gly Lys Leu
         115                 120                 125            
 Ala Leu Asn Gln Ile Ser Gln Ile Ser Met Lys Ser Pro Gln Leu Ile
     130                 135                 140                
 Leu Val Asn Met Ala Ser Phe Pro Glu Cys Thr Ala Ala Ala Ile Lys
 145                 150                 155                 160
 Ala Ile Arg Glu Ser Gly Met Asn Leu Asn Pro Glu Val Glu Gly Thr
                 165                 170                 175    
 Leu Ile Arg Val Pro Ile Pro Gln Val Thr Arg Glu His Arg Glu Met
             180                 185                 190        
 Leu Val Lys Leu Ala Lys Gln Asn Thr Asn Lys Ala Lys Asp Ser Leu
         195                 200                 205            
 Arg Lys Val Arg Thr Asn Ser Met Asn Lys Leu Lys Lys Ser Lys Asp
     210                 215                 220                
 Thr Val Ser Glu Asp Thr Ile Arg Leu Ile Glu Lys Gln Ile Ser Gln
 225                 230                 235                 240
 Met Ala Asp Asp Thr Val Ala Glu Leu Asp Arg His Leu Ala Val Lys
                 245                 250                 255    
 Thr Lys Glu Leu Leu Gly
             260        



      <210> 633
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 633
 Met Gly Lys Ile Ala Leu Gln Leu Lys Ala Thr Leu Glu Asn Ile Thr
   1               5                  10                  15    
 Asn Leu Arg Pro Val Gly Glu Asp Phe Arg Trp Tyr Leu Lys Met Lys
              20                  25                  30        
 Cys Gly Asn Cys Gly Glu Ile Ser Asp Lys Trp Gln Tyr Ile Arg Leu
          35                  40                  45            
 Met Asp Ser Val Ala Leu Lys Gly Gly Arg Gly Ser Ala Ser Met Val
      50                  55                  60                
 Gln Lys Cys Lys Leu Cys Ala Arg Glu Asn Ser Ile Glu Ile Leu Ser
  65                  70                  75                  80
 Ser Thr Ile Lys Pro Tyr Asn Ala Glu Asp Asn Glu Asn Phe Lys Thr
                  85                  90                  95    
 Ile Val Glu Phe Glu Cys Arg Gly Leu Glu Pro Val Asp Phe Gln Pro
             100                 105                 110        
 Gln Ala Gly Phe Ala Ala Glu Gly Val Glu Ser Gly Thr Ala Phe Ser
         115                 120                 125            
 Asp Ile Asn Leu Gln Glu Lys Asp Trp Thr Asp Tyr Asp Glu Lys Ala
     130                 135                 140                
 Gln Glu Ser Val Gly Ile Tyr Glu Val Thr His Gln Phe Val Lys Cys
 145                 150                 155                 160





      <210> 634
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 634
 Met Lys Arg Glu Ser Thr Leu Lys Phe Ile Thr Ser Leu Leu Pro Thr
   1               5                  10                  15    
 Met Lys Ser Thr Thr Cys Ile Trp Tyr Gln Ala Gly Arg Gln Met Arg
              20                  25                  30        
 Arg Glu Glu Glu Glu Glu Glu Glu Lys Ala Leu Gly Ser Ser Ala Lys
          35                  40                  45            
 Ile Lys Ile Lys Lys
      50            



      <210> 635
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 635
 Met Glu Phe Pro Asp Leu Gly Ala His Cys Ser Glu Pro Ser Cys Gln
   1               5                  10                  15    
 Arg Leu Asp Phe Leu Pro Leu Lys Cys Asp Ala Cys Ser Gly Ile Phe
              20                  25                  30        
 Cys Ala Asp His Val Ala Tyr Ala Gln His His Cys Gly Ser Ala Tyr
          35                  40                  45            
 Gln Lys Asp Ile Gln Val Pro Val Cys Pro Leu Cys Asn Val Pro Val
      50                  55                  60                
 Pro Val Ala Arg Gly Glu Pro Pro Asp Arg Ala Val Gly Glu His Ile
  65                  70                  75                  80
 Asp Arg Asp Cys Arg Ser Asp Pro Ala Gln Gln Lys Arg Lys Ile Phe
                  85                  90                  95    
 Thr Asn Lys Cys Glu Arg Ala Gly Cys Arg Gln Arg Glu Met Met Lys
             100                 105                 110        
 Leu Thr Cys Glu Arg Cys Ser Arg Asn Phe Cys Ile Lys His Arg His
         115                 120                 125            
 Pro Leu Asp His Asp Cys Ser Gly Glu Gly His Pro Thr Ser Arg Ala
     130                 135                 140                
 Gly Leu Ala Ala Ile Ser Arg Ala Gln Ala Val Ala Ser Thr Ser Thr
 145                 150                 155                 160
 Val Pro Ser Pro Ser Gln Thr Met Pro Ser Cys Thr Ser Pro Ser Arg
                 165                 170                 175    
 Ala Thr Thr Arg Ser Pro Ser Trp Thr Ala Pro Pro Val Ile Ala Leu
             180                 185                 190        
 Gln Asn Gly Leu Ser Glu Asp Glu Ala Leu Gln Arg Ala Leu Glu Met
         195                 200                 205            
 Ser Leu Ala Glu Thr Lys Pro Gln Val Pro Ser Cys Gln Glu Glu Glu
     210                 215                 220                
 Asp Leu Ala Leu Ala Gln Ala Leu Ser Ala Ser Glu Ala Glu Tyr Gln
 225                 230                 235                 240
 Arg His Glu Ala Gln Ser Arg Ser Ser Lys Pro Ser Asn Cys Ser Leu
                 245                 250                 255    
 Cys
    



      <210> 636
      <211> 1145
      <212> PRT
      <213> Homo sapiens


      <400> 636
 Met Pro Asn Glu Ile Thr Ser Ala Asp Thr Ile Arg Ala Leu Phe Val
   1               5                  10                  15    
 Ser Ala Phe Pro Gln Gln Leu Thr Met Lys Met Leu Glu Ser Pro Ser
              20                  25                  30        
 Val Ala Ile Tyr Ile Lys Asp Glu Ser Arg Asn Val Tyr Tyr Glu Leu
          35                  40                  45            
 Asn Asp Val Arg Asn Ile Gln Asp Arg Ser Leu Leu Lys Val Tyr Asn
      50                  55                  60                
 Lys Asp Pro Ala His Ala Phe Asn His Thr Pro Lys Thr Met Asn Gly
  65                  70                  75                  80
 Asp Met Arg Met Gln Arg Glu Leu Val Tyr Ala Arg Gly Asp Gly Pro
                  85                  90                  95    
 Gly Ala Pro Arg Pro Gly Ser Thr Ala His Pro Pro His Ala Ile Pro
             100                 105                 110        
 Asn Ser Pro Pro Ser Thr Pro Val Pro His Ser Met Pro Pro Ser Pro
         115                 120                 125            
 Ser Arg Ile Pro Tyr Gly Gly Thr Arg Ser Met Val Val Pro Gly Asn
     130                 135                 140                
 Ala Thr Ile Pro Arg Asp Arg Ile Ser Ser Leu Pro Val Ser Arg Pro
 145                 150                 155                 160
 Ile Ser Pro Ser Pro Ser Ala Ile Leu Glu Arg Arg Asp Val Lys Pro
                 165                 170                 175    
 Asp Glu Asp Met Ser Gly Lys Asn Ile Ala Met Tyr Arg Asn Glu Gly
             180                 185                 190        
 Phe Tyr Ala Asp Pro Tyr Leu Tyr His Glu Gly Arg Met Ser Ile Ala
         195                 200                 205            
 Ser Ser His Gly Gly His Pro Leu Asp Val Pro Asp His Ile Ile Ala
     210                 215                 220                
 Tyr His Arg Thr Ala Ile Arg Ser Ala Ser Ala Tyr Cys Asn Pro Ser
 225                 230                 235                 240
 Met Gln Ala Glu Met His Met Glu Gln Ser Leu Tyr Arg Gln Lys Ser
                 245                 250                 255    
 Arg Lys Tyr Pro Asp Ser His Leu Pro Thr Leu Gly Ser Lys Thr Pro
             260                 265                 270        
 Pro Ala Ser Pro His Arg Val Ser Asp Leu Arg Met Ile Asp Met His
         275                 280                 285            
 Ala His Tyr Asn Ala His Gly Pro Pro His Thr Met Gln Pro Asp Arg
     290                 295                 300                
 Ala Ser Pro Ser Arg Gln Ala Phe Lys Lys Glu Pro Gly Thr Leu Val
 305                 310                 315                 320
 Tyr Ile Glu Lys Pro Arg Ser Ala Ala Gly Leu Ser Ser Leu Val Asp
                 325                 330                 335    
 Leu Gly Pro Pro Leu Met Glu Lys Gln Val Phe Ala Tyr Ser Thr Ala
             340                 345                 350        
 Thr Ile Pro Lys Asp Arg Glu Thr Arg Glu Arg Met Gln Ala Met Glu
         355                 360                 365            
 Lys Gln Ile Ala Ser Leu Thr Gly Leu Val Gln Ser Ala Leu Phe Lys
     370                 375                 380                
 Gly Pro Ile Thr Ser Tyr Ser Lys Asp Ala Ser Ser Glu Lys Met Met
 385                 390                 395                 400
 Lys Thr Thr Ala Asn Arg Ser His Thr Asp Ser Ala Gly Thr Pro His
                 405                 410                 415    
 Val Ser Gly Gly Lys Met Leu Ser Ala Leu Glu Ser Thr Val Pro Pro
             420                 425                 430        
 Ser Gln Pro Pro Pro Val Gly Thr Ser Ala Ile His Met Ser Leu Leu
         435                 440                 445            
 Glu Met Arg Arg Ser Val Ala Glu Leu Arg Leu Gln Leu Gln Gln Met
     450                 455                 460                
 Arg Gln Leu Gln Leu Gln Asn Gln Glu Leu Leu Arg Ala Met Met Lys
 465                 470                 475                 480
 Lys Ala Glu Leu Glu Ile Ser Gly Lys Val Met Glu Thr Met Lys Arg
                 485                 490                 495    
 Leu Glu Asp Pro Val Gln Arg Gln Arg Val Leu Val Glu Gln Glu Arg
             500                 505                 510        
 Gln Lys Tyr Leu His Glu Glu Glu Lys Ile Val Lys Lys Leu Cys Glu
         515                 520                 525            
 Leu Glu Asp Phe Val Glu Asp Leu Lys Lys Asp Ser Thr Ala Ala Ser
     530                 535                 540                
 Arg Leu Val Thr Leu Lys Asp Val Glu Asp Gly Ala Phe Leu Leu Arg
 545                 550                 555                 560
 Gln Val Gly Glu Ala Val Ala Thr Leu Lys Gly Glu Phe Pro Thr Leu
                 565                 570                 575    
 Gln Asn Lys Met Arg Ala Ile Leu Arg Ile Glu Val Glu Ala Val Arg
             580                 585                 590        
 Phe Leu Lys Glu Glu Pro His Lys Leu Asp Ser Leu Leu Lys Arg Val
         595                 600                 605            
 Arg Ser Met Thr Asp Val Leu Thr Met Leu Arg Arg His Val Thr Asp
     610                 615                 620                
 Gly Leu Leu Lys Gly Thr Asp Ala Ala Gln Ala Ala Gln Tyr Met Ala
 625                 630                 635                 640
 Met Glu Lys Ala Thr Ala Ala Glu Val Leu Lys Ser Gln Glu Glu Ala
                 645                 650                 655    
 Ala His Thr Ser Gly Gln Pro Phe His Ser Thr Gly Ala Pro Gly Asp
             660                 665                 670        
 Ala Lys Ser Glu Val Val Pro Leu Ser Gly Met Met Val Arg His Ala
         675                 680                 685            
 Gln Ser Ser Pro Val Val Ile Gln Pro Ser Gln His Ser Val Ala Leu
     690                 695                 700                
 Leu Asn Pro Ala Gln Asn Leu Pro His Val Ala Ser Ser Pro Ala Val
 705                 710                 715                 720
 Pro Gln Glu Ala Thr Ser Thr Leu Gln Met Ser Gln Ala Pro Gln Ser
                 725                 730                 735    
 Pro Gln Ile Pro Met Asn Gly Ser Ala Met Gln Ser Leu Phe Ile Glu
             740                 745                 750        
 Glu Ile His Ser Val Ser Ala Lys Asn Arg Ala Val Ser Ile Glu Lys
         755                 760                 765            
 Ala Glu Lys Lys Trp Glu Glu Lys Arg Gln Asn Leu Asp His Tyr Asn
     770                 775                 780                
 Gly Lys Glu Phe Glu Lys Leu Leu Glu Glu Ala Gln Ala Asn Ile Met
 785                 790                 795                 800
 Lys Ser Ile Pro Asn Leu Glu Met Pro Pro Ala Thr Gly Pro Leu Pro
                 805                 810                 815    
 Arg Gly Asp Ala Pro Val Asp Lys Val Glu Leu Ser Glu Asp Ser Pro
             820                 825                 830        
 Asn Ser Glu Gln Asp Leu Glu Lys Leu Gly Gly Lys Ser Pro Pro Pro
         835                 840                 845            
 Pro Pro Pro Pro Pro Arg Arg Ser Tyr Leu Pro Gly Ser Gly Leu Thr
     850                 855                 860                
 Thr Thr Arg Ser Gly Asp Val Val Tyr Thr Gly Arg Lys Glu Asn Ile
 865                 870                 875                 880
 Thr Ala Lys Ala Ser Ser Glu Asp Ala Gly Pro Ser Pro Gln Thr Arg
                 885                 890                 895    
 Ala Thr Lys Tyr Pro Ala Glu Glu Pro Ala Ser Ala Trp Thr Pro Ser
             900                 905                 910        
 Pro Pro Pro Val Thr Thr Ser Ser Ser Lys Asp Glu Glu Glu Glu Glu
         915                 920                 925            
 Glu Glu Gly Asp Lys Ile Met Ala Glu Leu Gln Gly Ser Ser Gly Ala
     930                 935                 940                
 Leu Gln Thr Ser Arg Met Pro Val Pro Met Ser Ala Lys Asn Arg Pro
 945                 950                 955                 960
 Gly Thr Leu Asp Lys Pro Gly Lys Gln Ser Lys Leu Gln Asp Pro Arg
                 965                 970                 975    
 Gln Tyr Arg Gln Ala Asn Gly Ser Ala Lys Lys Ser Gly Gly Asp Phe
             980                 985                 990        
 Lys Pro Thr Ser Pro Ser Leu Pro Ala Ser Lys Ile Pro Ala Leu Ser
         995                1000                1005            
 Pro Ser Ser Gly Lys Ser Ser Ser Leu Pro Ser Ser Ser Gly Asp Ser
    1010                1015                1020                
 Ser Asn Leu Pro Asn Pro Pro Ala Thr Lys Pro Ser Ile Ala Ser Asn
1025                1030                1035                1040
 Pro Leu Ser Pro Gln Thr Gly Pro Pro Ala His Ser Ala Ser Leu Ile
                1045                1050                1055    
 Pro Ser Val Ser Asn Gly Ser Leu Lys Phe Gln Ser Leu Thr His Thr
            1060                1065                1070        
 Gly Lys Gly His His Leu Ser Phe Ser Pro Gln Ser Gln Asn Gly Arg
        1075                1080                1085            
 Ala Pro Pro Pro Leu Ser Phe Ser Ser Ser Pro Pro Ser Pro Ala Ser
    1090                1095                1100                
 Ser Val Ser Leu Asn Gln Gly Ala Lys Gly Thr Arg Thr Ile His Thr
1105                1110                1115                1120
 Pro Ser Leu Thr Ser Tyr Lys Ala Gln Asn Gly Ser Ser Ser Lys Ala
                1125                1130                1135    
 Thr Pro Ser Thr Ala Lys Glu Thr Ser
            1140                1145



      <210> 637
      <211> 1205
      <212> PRT
      <213> Homo sapiens


      <400> 637
 Met Arg Lys Pro Arg Arg Lys Ser Arg Gln Asn Ala Glu Gly Arg Arg
   1               5                  10                  15    
 Ser Pro Ser Pro Tyr Ser Leu Lys Cys Ser Pro Thr Arg Glu Thr Leu
              20                  25                  30        
 Thr Tyr Ala Gln Ala Gln Arg Ile Val Glu Val Asp Ile Asp Gly Arg
          35                  40                  45            
 Leu His Arg Ile Ser Ile Tyr Asp Pro Leu Lys Ile Ile Thr Glu Asp
      50                  55                  60                
 Glu Leu Thr Ala Gln Asp Ile Thr Glu Cys Asn Ser Asn Lys Glu Asn
  65                  70                  75                  80
 Ser Glu Gln Pro Gln Phe Pro Gly Lys Ser Lys Lys Pro Ser Ser Lys
                  85                  90                  95    
 Gly Lys Lys Lys Glu Ser Cys Ser Lys His Ala Ser Gly Thr Ser Phe
             100                 105                 110        
 His Leu Pro Gln Pro Ser Phe Arg Met Val Asp Ser Gly Ile Gln Pro
         115                 120                 125            
 Glu Ala Pro Pro Leu Pro Ala Ala Tyr Tyr Arg Tyr Ile Glu Lys Pro
     130                 135                 140                
 Pro Glu Asp Leu Asp Ala Glu Val Glu Tyr Asp Met Asp Glu Glu Asp
 145                 150                 155                 160
 Leu Ala Trp Leu Asp Met Val Asn Glu Lys Arg Arg Val Asp Gly His
                 165                 170                 175    
 Gly Leu Val Ser Ala Asp Thr Phe Glu Leu Leu Val Asp Arg Leu Glu
             180                 185                 190        
 Lys Glu Ser Tyr Leu Glu Ser Arg Ser Ser Gly Ala Gln Gln Ser Leu
         195                 200                 205            
 Ile Asp Glu Asp Ala Phe Cys Cys Val Cys Leu Asp Asp Glu Cys His
     210                 215                 220                
 Asn Ser Asn Val Ile Leu Phe Cys Asp Ile Cys Asn Leu Ala Val His
 225                 230                 235                 240
 Gln Glu Cys Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp Leu Cys
                 245                 250                 255    
 Arg Cys Cys Leu Gln Ser Pro Ser Arg Pro Val Asp Cys Ile Leu Cys
             260                 265                 270        
 Pro Asn Lys Gly Gly Ala Phe Lys Gln Thr Ser Asp Gly His Trp Ala
         275                 280                 285            
 His Val Val Cys Ala Ile Trp Ile Pro Glu Val Cys Phe Ala Asn Thr
     290                 295                 300                
 Val Phe Leu Glu Pro Ile Glu Gly Ile Asp Asn Ile Pro Pro Ala Arg
 305                 310                 315                 320
 Trp Lys Leu Thr Cys Tyr Ile Cys Lys Gln Lys Gly Leu Gly Ala Ala
                 325                 330                 335    
 Ile Gln Cys His Lys Val Asn Cys Tyr Thr Ala Phe His Val Thr Cys
             340                 345                 350        
 Ala Gln Arg Ala Gly Leu Phe Met Lys Ile Glu Pro Met Arg Glu Thr
         355                 360                 365            
 Ser Leu Asn Gly Thr Ile Phe Thr Val Arg Lys Thr Ala Tyr Cys Glu
     370                 375                 380                
 Ala His Ser Pro Pro Gly Ala Ala Thr Ala Arg Arg Lys Gly Asp Ser
 385                 390                 395                 400
 Pro Arg Ser Ile Ser Glu Thr Gly Asp Glu Glu Gly Leu Lys Glu Gly
                 405                 410                 415    
 Asp Gly Glu Glu Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Gln Glu
             420                 425                 430        
 Ala Gln Gly Gly Val Ser Gly Ser Leu Lys Gly Val Pro Lys Lys Ser
         435                 440                 445            
 Lys Met Ser Leu Lys Gln Lys Ile Lys Lys Glu Pro Glu Glu Ala Gly
     450                 455                 460                
 Gln Asp Thr Pro Ser Thr Leu Pro Met Leu Ala Val Pro Gln Ile Pro
 465                 470                 475                 480
 Ser Tyr Arg Leu Asn Lys Ile Cys Ser Gly Leu Ser Phe Gln Arg Lys
                 485                 490                 495    
 Asn Gln Phe Met Gln Arg Leu His Asn Tyr Trp Leu Leu Lys Arg Gln
             500                 505                 510        
 Ala Arg Asn Gly Val Pro Leu Ile Arg Arg Leu His Ser His Leu Gln
         515                 520                 525            
 Ser Gln Arg Asn Ala Glu Gln Arg Glu Gln Asp Glu Lys Thr Ser Ala
     530                 535                 540                
 Val Lys Glu Glu Leu Lys Tyr Trp Gln Lys Leu Arg His Asp Leu Glu
 545                 550                 555                 560
 Arg Ala Arg Leu Leu Ile Glu Leu Ile Arg Lys Arg Glu Lys Leu Lys
                 565                 570                 575    
 Arg Glu Gln Val Lys Val Gln Gln Ala Ala Met Glu Leu Glu Leu Met
             580                 585                 590        
 Pro Phe Asn Val Leu Leu Arg Thr Thr Leu Asp Leu Leu Gln Glu Lys
         595                 600                 605            
 Asp Pro Ala His Ile Phe Ala Glu Pro Val Asn Leu Ser Glu Val Pro
     610                 615                 620                
 Asp Tyr Leu Glu Phe Ile Ser Lys Pro Met Asp Phe Ser Thr Met Arg
 625                 630                 635                 640
 Arg Lys Leu Glu Ser His Leu Tyr Arg Thr Leu Glu Glu Phe Glu Glu
                 645                 650                 655    
 Asp Phe Asn Leu Ile Val Thr Asn Cys Met Lys Tyr Asn Ala Lys Asp
             660                 665                 670        
 Thr Ile Phe His Arg Ala Ala Val Arg Leu Arg Asp Leu Gly Gly Ala
         675                 680                 685            
 Ile Leu Arg His Ala Arg Arg Gln Ala Glu Asn Ile Gly Tyr Asp Pro
     690                 695                 700                
 Glu Arg Gly Thr His Leu Pro Glu Ser Pro Lys Leu Glu Asp Phe Tyr
 705                 710                 715                 720
 Arg Phe Ser Trp Glu Asp Val Asp Asn Ile Leu Ile Pro Glu Asn Arg
                 725                 730                 735    
 Ala His Leu Ser Pro Glu Val Gln Leu Lys Glu Leu Leu Glu Lys Leu
             740                 745                 750        
 Asp Leu Val Ser Ala Met Arg Ser Ser Gly Ala Arg Thr Arg Arg Val
         755                 760                 765            
 Arg Leu Leu Arg Arg Glu Ile Asn Ala Leu Arg Gln Lys Leu Ala Gln
     770                 775                 780                
 Pro Pro Pro Pro Gln Pro Pro Ser Leu Asn Lys Thr Val Ser Asn Gly
 785                 790                 795                 800
 Glu Leu Pro Ala Gly Pro Gln Gly Asp Ala Ala Val Leu Glu Gln Ala
                 805                 810                 815    
 Leu Gln Glu Glu Pro Glu Asp Asp Gly Asp Arg Asp Asp Ser Lys Leu
             820                 825                 830        
 Pro Pro Pro Pro Thr Leu Glu Pro Thr Gly Pro Ala Pro Ser Leu Ser
         835                 840                 845            
 Glu Gln Glu Ser Pro Pro Glu Pro Pro Thr Leu Lys Pro Ile Asn Asp
     850                 855                 860                
 Ser Lys Pro Pro Ser Arg Phe Leu Lys Pro Arg Lys Val Glu Glu Asp
 865                 870                 875                 880
 Glu Leu Leu Glu Lys Ser Pro Leu Gln Leu Gly Asn Glu Pro Leu Gln
                 885                 890                 895    
 Arg Leu Leu Ser Asp Asn Gly Ile Asn Arg Leu Ser Leu Met Ala Pro
             900                 905                 910        
 Asp Thr Pro Ala Gly Thr Pro Leu Ser Gly Val Gly Arg Arg Thr Ser
         915                 920                 925            
 Val Leu Phe Lys Lys Ala Lys Asn Gly Val Lys Leu Gln Arg Ser Pro
     930                 935                 940                
 Asp Arg Val Leu Glu Asn Gly Glu Asp His Gly Val Ala Gly Ser Pro
 945                 950                 955                 960
 Ala Ser Pro Ala Ser Ile Glu Glu Glu Arg His Ser Arg Lys Arg Pro
                 965                 970                 975    
 Arg Ser Arg Ser Cys Ser Glu Ser Glu Gly Glu Arg Ser Pro Gln Gln
             980                 985                 990        
 Glu Glu Glu Thr Gly Met Thr Asn Gly Phe Gly Lys His Thr Glu Ser
         995                1000                1005            
 Gly Ser Asp Ser Glu Cys Ser Leu Gly Leu Ser Gly Gly Leu Ala Phe
    1010                1015                1020                
 Glu Ala Cys Ser Gly Leu Thr Pro Pro Lys Arg Ser Arg Gly Lys Pro
1025                1030                1035                1040
 Ala Leu Ser Arg Val Pro Phe Leu Glu Gly Val Asn Gly Asp Ser Asp
                1045                1050                1055    
 Tyr Asn Gly Ser Gly Arg Ser Leu Leu Leu Pro Phe Glu Asp Arg Gly
            1060                1065                1070        
 Asp Leu Glu Pro Leu Glu Leu Val Trp Ala Lys Cys Arg Gly Tyr Pro
        1075                1080                1085            
 Ser Tyr Pro Ala Leu Ile Ile Asp Pro Lys Met Pro Arg Glu Gly Leu
    1090                1095                1100                
 Leu His Asn Gly Val Pro Ile Pro Val Pro Pro Leu Asp Val Leu Lys
1105                1110                1115                1120
 Leu Gly Glu Gln Lys Gln Ala Glu Ala Gly Glu Lys Leu Phe Leu Val
                1125                1130                1135    
 Leu Phe Phe Asp Asn Lys Arg Thr Trp Gln Trp Leu Pro Arg Asp Lys
            1140                1145                1150        
 Val Leu Pro Leu Gly Val Glu Asp Thr Val Asp Lys Leu Lys Met Leu
        1155                1160                1165            
 Glu Gly Arg Lys Thr Ser Ile Arg Lys Ser Val Gln Val Ala Tyr Asp
    1170                1175                1180                
 Arg Ala Met Ile His Leu Ser Arg Val Arg Gly Pro His Ser Phe Val
1185                1190                1195                1200
 Thr Ser Ser Tyr Leu
                1205



      <210> 638
      <211> 725
      <212> PRT
      <213> Homo sapiens


      <400> 638
 Met Gly Val Ser Gly Arg Pro Val Cys Gly Val Ala Gly Ile Pro Ser
   1               5                  10                  15    
 Ser Gln Ser Gly Ala Gln His His Gly Gln His Pro Ala Gly Ser Ala
              20                  25                  30        
 Ala Pro Leu Pro His Cys Ser His Ala Gly Ser Ala Gly Ser Ala Leu
          35                  40                  45            
 Ala Tyr Arg Thr Gln Met Asp Thr Ser Pro Ala Ile Leu Met Pro Ser
      50                  55                  60                
 Ser Leu Gln Thr Pro Gln Thr Gln Glu Gln Asn Gly Ile Leu Asp Trp
  65                  70                  75                  80
 Leu Arg Lys Leu Arg Leu His Lys Tyr Tyr Pro Val Phe Lys Gln Leu
                  85                  90                  95    
 Ser Met Glu Lys Phe Leu Ser Leu Thr Glu Glu Asp Leu Asn Lys Phe
             100                 105                 110        
 Glu Ser Leu Thr Met Gly Ala Lys Lys Lys Leu Lys Thr Gln Leu Glu
         115                 120                 125            
 Leu Glu Lys Glu Lys Ser Glu Arg Arg Cys Leu Asn Pro Ser Ala Pro
     130                 135                 140                
 Pro Leu Val Thr Ser Ser Gly Val Ala Arg Val Pro Pro Thr Ser His
 145                 150                 155                 160
 Val Gly Pro Val Gln Ser Gly Arg Gly Ser His Ala Ala Glu Leu Arg
                 165                 170                 175    
 Val Glu Val Glu Gln Pro His His Gln Leu Pro Arg Glu Gly Ser Ser
             180                 185                 190        
 Ser Glu Tyr Ser Ser Ser Ser Ser Ser Pro Met Gly Val Gln Ala Arg
         195                 200                 205            
 Glu Glu Ser Ser Asp Ser Ala Glu Glu Asn Asp Arg Arg Val Glu Ile
     210                 215                 220                
 His Leu Glu Ser Ser Asp Lys Glu Lys Pro Val Met Leu Leu Asn His
 225                 230                 235                 240
 Phe Thr Ser Ser Ser Ala Arg Pro Thr Ala Gln Val Leu Pro Val Gln
                 245                 250                 255    
 Asn Glu Ala Ser Ser Asn Pro Ser Gly His His Pro Leu Pro Pro Gln
             260                 265                 270        
 Met Leu Ser Ala Ala Ser His Ile Thr Pro Ile Arg Met Leu Asn Ser
         275                 280                 285            
 Val His Lys Pro Glu Arg Gly Ser Ala Asp Met Lys Leu Leu Ser Ser
     290                 295                 300                
 Ser Val His Ser Leu Leu Ser Leu Glu Glu Arg Asn Lys Gly Ser Gly
 305                 310                 315                 320
 Pro Arg Ser Ser Met Lys Val Asp Lys Ser Phe Gly Ser Ala Met Met
                 325                 330                 335    
 Asp Val Leu Pro Ala Ser Ala Pro His Gln Pro Val Gln Val Leu Ser
             340                 345                 350        
 Gly Leu Ser Glu Ser Ser Ser Met Ser Pro Thr Val Ser Phe Gly Pro
         355                 360                 365            
 Arg Thr Lys Val Val His Ala Ser Thr Leu Asp Arg Val Leu Lys Thr
     370                 375                 380                
 Ala Gln Gln Pro Ala Leu Val Val Glu Thr Ser Thr Ala Ala Thr Gly
 385                 390                 395                 400
 Thr Pro Ser Thr Val Leu His Ala Ala Arg Pro Pro Ile Lys Leu Leu
                 405                 410                 415    
 Leu Ser Ser Ser Val Pro Ala Asp Ser Ala Ile Ser Gly Gln Thr Ser
             420                 425                 430        
 Cys Pro Asn Asn Val Gln Ile Ser Val Pro Pro Ala Ile Ile Asn Pro
         435                 440                 445            
 Arg Thr Ala Leu Tyr Thr Ala Asn Thr Lys Val Ala Phe Ser Ala Met
     450                 455                 460                
 Ser Ser Met Pro Val Gly Pro Leu Gln Gly Gly Phe Cys Ala Asn Ser
 465                 470                 475                 480
 Asn Thr Ala Ser Pro Ser Ser His Pro Ser Thr Ser Phe Ala Asn Met
                 485                 490                 495    
 Ala Thr Leu Pro Ser Cys Pro Ala Pro Ser Ser Ser Pro Ala Leu Ser
             500                 505                 510        
 Ser Val Pro Glu Ser Ser Phe Tyr Ser Ser Ser Gly Gly Gly Gly Ser
         515                 520                 525            
 Thr Gly Asn Ile Pro Ala Ser Asn Pro Asn His His His His His His
     530                 535                 540                
 His Gln Gln Pro Pro Ala Pro Pro Gln Pro Ala Pro Pro Pro Pro Gly
 545                 550                 555                 560
 Cys Ile Val Cys Thr Ser Cys Gly Cys Ser Gly Ser Cys Gly Ser Ser
                 565                 570                 575    
 Gly Leu Thr Val Ser Tyr Ala Asn Tyr Phe Gln His Pro Phe Ser Gly
             580                 585                 590        
 Pro Ser Val Phe Thr Phe Pro Phe Leu Pro Phe Ser Pro Met Cys Ser
         595                 600                 605            
 Ser Gly Tyr Val Ser Ala Gln Gln Tyr Gly Gly Gly Ser Thr Phe Pro
     610                 615                 620                
 Val Val His Ala Pro Tyr Ser Ser Ser Gly Thr Pro Asp Pro Val Leu
 625                 630                 635                 640
 Ser Gly Gln Ser Thr Phe Ala Val Pro Pro Met Gln Asn Phe Met Ala
                 645                 650                 655    
 Gly Thr Ala Gly Val Tyr Gln Thr Gln Gly Leu Val Gly Ser Ser Asn
             660                 665                 670        
 Gly Ser Ser His Lys Lys Ser Gly Asn Leu Ser Cys Tyr Asn Cys Gly
         675                 680                 685            
 Ala Thr Gly His Arg Ala Gln Asp Cys Lys Gln Pro Ser Met Asp Phe
     690                 695                 700                
 Asn Arg Pro Gly Thr Phe Arg Leu Lys Tyr Ala Pro Pro Ala Glu Ser
 705                 710                 715                 720
 Leu Asp Ser Thr Asp
                 725



      <210> 639
      <211> 800
      <212> PRT
      <213> Homo sapiens


      <400> 639
 Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu
   1               5                  10                  15    
 Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg
              20                  25                  30        
 Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu
          35                  40                  45            
 Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn
      50                  55                  60                
 Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile
  65                  70                  75                  80
 Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser
                  85                  90                  95    
 Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr
             100                 105                 110        
 Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys
         115                 120                 125            
 Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp
     130                 135                 140                
 Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His
 145                 150                 155                 160
 Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu
                 165                 170                 175    
 Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr
             180                 185                 190        
 Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly
         195                 200                 205            
 Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg
     210                 215                 220                
 Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His
 225                 230                 235                 240
 Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile
                 245                 250                 255    
 Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys
             260                 265                 270        
 Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu
         275                 280                 285            
 Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys
     290                 295                 300                
 Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln
 305                 310                 315                 320
 Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile
                 325                 330                 335    
 Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val
             340                 345                 350        
 Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe
         355                 360                 365            
 Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu
     370                 375                 380                
 Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe
 385                 390                 395                 400
 Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His
                 405                 410                 415    
 Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu
             420                 425                 430        
 Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro
         435                 440                 445            
 Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp
     450                 455                 460                
 Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr
 465                 470                 475                 480
 Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val
                 485                 490                 495    
 Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys
             500                 505                 510        
 Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His
         515                 520                 525            
 Val His Leu Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys
     530                 535                 540                
 Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn
 545                 550                 555                 560
 Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr
                 565                 570                 575    
 Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln
             580                 585                 590        
 Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln
         595                 600                 605            
 Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr
     610                 615                 620                
 Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln
 625                 630                 635                 640
 Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp
                 645                 650                 655    
 Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg
             660                 665                 670        
 Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu
         675                 680                 685            
 Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr
     690                 695                 700                
 Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser
 705                 710                 715                 720
 Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp
                 725                 730                 735    
 Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr
             740                 745                 750        
 Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp
         755                 760                 765            
 Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys
     770                 775                 780                
 Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe
 785                 790                 795                 800





      <210> 640
      <211> 511
      <212> PRT
      <213> Homo sapiens


      <400> 640
 Met Phe Asn Cys Cys Ser His Gly Thr Leu Leu His Phe Gly Leu Gln
   1               5                  10                  15    
 Ser Ser Val Glu Ala Val Thr Ala Ser Thr Glu Leu Leu Gly Arg Cys
              20                  25                  30        
 Gln Arg Pro Cys His Arg His Val Ala Asp Met Val Ile Ser Glu Ser
          35                  40                  45            
 Met Asp Ile Leu Phe Arg Ile Arg Gly Gly Leu Asp Leu Ala Phe Gln
      50                  55                  60                
 Leu Ala Thr Pro Asn Glu Ile Phe Leu Lys Lys Ala Leu Lys His Val
  65                  70                  75                  80
 Leu Ser Asp Leu Ser Thr Lys Leu Ser Ser Asn Ala Leu Val Phe Arg
                  85                  90                  95    
 Ile Cys His Ser Ser Val Tyr Ile Trp Pro Ser Ser Asp Ile Asn Thr
             100                 105                 110        
 Ile Pro Gly Glu Leu Thr Asp Ala Ser Ala Cys Lys Asn Ile Leu Arg
         115                 120                 125            
 Phe Ile Gln Phe Glu Pro Glu Glu Asp Ile Lys Arg Lys Phe Met Arg
     130                 135                 140                
 Lys Lys Asp Lys Lys Leu Ser Asp Met His Gln Ile Val Asn Ile Asp
 145                 150                 155                 160
 Leu Met Leu Glu Met Ser Thr Ser Leu Ala Ala Val Thr Pro Ile Ile
                 165                 170                 175    
 Glu Arg Glu Ser Gly Gly His His Tyr Val Asn Met Thr Leu Pro Val
             180                 185                 190        
 Asp Ala Val Ile Ser Val Ala Pro Glu Glu Thr Trp Gly Lys Val Arg
         195                 200                 205            
 Lys Leu Leu Val Asp Ala Ile His Asn Gln Leu Thr Asp Met Glu Lys
     210                 215                 220                
 Cys Ile Leu Lys Tyr Met Lys Gly Thr Ser Ile Val Val Pro Glu Pro
 225                 230                 235                 240
 Leu His Phe Leu Leu Pro Gly Lys Lys Asn Leu Val Thr Ile Ser Tyr
                 245                 250                 255    
 Pro Ser Gly Ile Pro Asp Gly Gln Leu Gln Ala Tyr Arg Lys Glu Leu
             260                 265                 270        
 His Asp Leu Phe Asn Leu Pro His Asp Arg Pro Tyr Phe Lys Arg Ser
         275                 280                 285            
 Asn Ala Tyr His Phe Pro Asp Glu Pro Tyr Lys Asp Gly Tyr Ile Arg
     290                 295                 300                
 Asn Pro His Thr Tyr Leu Asn Pro Pro Asn Met Glu Thr Gly Met Ile
 305                 310                 315                 320
 Tyr Val Val Gln Gly Ile Tyr Gly Tyr His His Tyr Met Gln Asp Arg
                 325                 330                 335    
 Ile Asp Asp Asn Gly Trp Gly Cys Ala Tyr Arg Ser Leu Gln Thr Ile
             340                 345                 350        
 Cys Ser Trp Phe Lys His Gln Gly Tyr Thr Glu Arg Ser Ile Pro Thr
         355                 360                 365            
 His Arg Glu Ile Gln Gln Ala Leu Val Asp Ala Gly Asp Lys Pro Ala
     370                 375                 380                
 Thr Phe Val Gly Ser Arg Gln Trp Ile Gly Ser Ile Glu Val Gln Leu
 385                 390                 395                 400
 Val Leu Asn Gln Leu Ile Gly Ile Thr Ser Lys Ile Leu Phe Val Ser
                 405                 410                 415    
 Gln Gly Ser Glu Ile Ala Ser Gln Gly Arg Glu Leu Ala Asn His Phe
             420                 425                 430        
 Gln Ser Glu Gly Thr Pro Val Met Ile Gly Gly Gly Val Leu Ala His
         435                 440                 445            
 Thr Ile Leu Gly Val Ala Trp Asn Glu Ile Thr Gly Gln Ile Lys Phe
     450                 455                 460                
 Leu Ile Leu Asp Pro His Tyr Thr Gly Ala Glu Asp Leu Gln Val Ile
 465                 470                 475                 480
 Leu Glu Lys Gly Trp Cys Gly Trp Lys Gly Pro Asp Phe Trp Asn Lys
                 485                 490                 495    
 Asp Ala Tyr Tyr Asn Leu Cys Leu Pro Gln Arg Pro Asn Met Ile
             500                 505                 510    



      <210> 641
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 641
 Met Asn Ala Ala Arg Leu Leu Phe His Lys Leu Ile Gln Pro Asp His
   1               5                  10                  15    
 Pro Gln Ile Ser Gln Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile
              20                  25                  30        
 Pro Lys Leu Thr Ser Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr
          35                  40                  45            
 Leu Thr Leu Pro Glu Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr
      50                  55                  60                
 Thr Ile Ala Ile Pro Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala
  65                  70                  75                  80
 Pro Leu Lys Val Leu Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu
                  85                  90                  95    
 Phe Leu Lys Ile Val Glu Leu Phe Lys Glu Val Val Val His Leu Leu
             100                 105                 110        
 Lys Leu Tyr Lys Ile Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn
         115                 120                 125            
 Ser Phe Leu His Thr Ala Leu Lys Val Leu Glu Ile Leu His Arg Val
     130                 135                 140                
 Asn Glu Lys Met Gly Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His
 145                 150                 155                 160
 Glu Val Gln Glu Leu Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val
                 165                 170                 175    
 Gln Gln Gln Ala Tyr Gly Met Leu Ala Asp Ile Pro Val Thr Ile Cys
             180                 185                 190        
 Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr Leu Leu Gln
         195                 200                 205            
 Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln Ala His Arg
     210                 215                 220                
 Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser Val Asn Pro
 225                 230                 235                 240
 Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly Asp Ala Met
                 245                 250                 255    
 Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys Pro Leu Lys
             260                 265                 270        
 Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly Val Arg Lys
         275                 280                 285            
 Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro Lys Tyr Gly
     290                 295                 300                
 Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe Ser Asp Lys
 305                 310                 315                 320
 Val Lys Cys Pro Thr Ile
                 325    



      <210> 642
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 642
 Met Ala Val Gly Lys Asn Lys Arg Leu Thr Lys Gly Gly Lys Lys Gly
   1               5                  10                  15    
 Ala Lys Lys Lys Val Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp
              20                  25                  30        
 Val Lys Ala Pro Ala Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Leu
          35                  40                  45            
 Val Thr Arg Thr Gln Gly Thr Lys Ile Ala Ser Asp Gly Leu Lys Gly
      50                  55                  60                
 Arg Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Val Ala
  65                  70                  75                  80
 Phe Arg Lys Phe Lys Leu Ile Thr Glu Asp Val Gln Gly Lys Asn Cys
                  85                  90                  95    
 Leu Thr Asn Phe His Gly Met Asp Leu Thr Arg Asp Lys Met Cys Ser
             100                 105                 110        
 Met Val Lys Lys Trp Gln Thr Met Ile Glu Ala His Val Asp Val Lys
         115                 120                 125            
 Thr Thr Asp Gly Tyr Leu Leu Arg Leu Phe Cys Val Gly Phe Thr Lys
     130                 135                 140                
 Lys Arg Asn Asn Gln Ile Arg Lys Thr Ser Tyr Ala Gln His Gln Gln
 145                 150                 155                 160
 Val Arg Gln Ile Arg Lys Lys Met Met Glu Ile Met Thr Arg Glu Val
                 165                 170                 175    
 Gln Thr Asn Asp Leu Lys Glu Val Val Asn Lys Leu Ile Pro Asp Ser
             180                 185                 190        
 Ile Gly Lys Asp Ile Glu Lys Ala Cys Gln Ser Ile Tyr Pro Leu His
         195                 200                 205            
 Asp Val Phe Val Arg Lys Val Lys Met Leu Lys Lys Pro Lys Phe Glu
     210                 215                 220                
 Leu Gly Lys Leu Met Glu Leu His Gly Glu Gly Ser Ser Ser Gly Lys
 225                 230                 235                 240
 Ala Thr Gly Asp Glu Thr Gly Ala Lys Val Glu Arg Ala Asp Gly Tyr
                 245                 250                 255    
 Glu Pro Pro Val Gln Glu Ser Val Lys Gly Arg Ile His Trp Ala Pro
             260                 265                 270        
 Ile Arg Arg Ile Ala Gly Val Thr Arg Thr Lys Gly Gly Gly Ala Lys
         275                 280                 285            
 Asn Thr Pro Arg Gly Gly His Glu Tyr Val Pro Arg Leu Cys Asn Arg
     290                 295                 300                
 Pro Gln Arg Ala Val Ile Thr Thr Ser Lys Arg Gly Tyr Thr Thr Trp
 305                 310                 315                 320
 Lys Lys Ser Gln Ala Leu Met Arg Thr Thr Trp Val Tyr Val Asn Thr
                 325                 330                 335    
 Pro Thr Asn Leu Asp Asn Ile Gln His Asp Ile Cys Thr Leu Thr
             340                 345                 350    



      <210> 643
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 643
 Met Ala Asp Val Val Val Gly Lys Asp Lys Gly Gly Glu Gln Arg Leu
   1               5                  10                  15    
 Ile Ser Leu Pro Leu Ser Arg Ile Arg Val Ile Met Lys Ser Ser Pro
              20                  25                  30        
 Glu Val Ser Ser Ile Asn Gln Glu Ala Leu Val Leu Thr Ala Lys Ala
          35                  40                  45            
 Thr Glu Leu Phe Val Gln Cys Leu Ala Thr Tyr Ser Tyr Arg His Gly
      50                  55                  60                
 Ser Gly Lys Glu Lys Lys Val Leu Thr Tyr Ser Asp Leu Ala Asn Thr
  65                  70                  75                  80
 Ala Gln Gln Ser Glu Thr Phe Gln Phe Leu Ala Asp Ile Leu Pro Lys
                  85                  90                  95    
 Lys Ile Leu Ala Ser Lys Tyr Leu Lys Met Leu Lys Glu Glu Lys Arg
             100                 105                 110        
 Glu Glu Asp Glu Glu Asn Asp Asn Asp Asn Glu Ser Asp His Asp Glu
         115                 120                 125            
 Ala Asp Ser
     130    



      <210> 644
      <211> 883
      <212> PRT
      <213> Homo sapiens


      <400> 644
 Met Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu
   1               5                  10                  15    
 Ala Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu
              20                  25                  30        
 Asn Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln
          35                  40                  45            
 Ile Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu
      50                  55                  60                
 Leu Ile Lys Ala Leu Lys Asp Ile Lys Val Gly Phe Val Lys Met Glu
  65                  70                  75                  80
 Ser Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val
                  85                  90                  95    
 Phe Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys
             100                 105                 110        
 Ala Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln
         115                 120                 125            
 Lys Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys Thr Ser
     130                 135                 140                
 Met Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu
 145                 150                 155                 160
 Leu Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg
                 165                 170                 175    
 Lys Asp Phe Asn Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln
             180                 185                 190        
 Gly Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys
         195                 200                 205            
 Pro Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe
     210                 215                 220                
 Tyr Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe
 225                 230                 235                 240
 Gln Asp Cys Ile Leu Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr
                 245                 250                 255    
 Asn Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu
             260                 265                 270        
 Gly Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys
         275                 280                 285            
 Asp Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu
     290                 295                 300                
 Trp Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met
 305                 310                 315                 320
 Tyr Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser
                 325                 330                 335    
 Met Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu
             340                 345                 350        
 Lys Glu Thr Leu Ala Gln Leu Ser Arg Glu Thr Asp Val Ser Pro Phe
         355                 360                 365            
 Pro Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser
     370                 375                 380                
 Leu Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp
 385                 390                 395                 400
 Thr Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro
                 405                 410                 415    
 Ser Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr
             420                 425                 430        
 Glu Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln
         435                 440                 445            
 Val Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro
     450                 455                 460                
 Glu Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val
 465                 470                 475                 480
 His Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp
                 485                 490                 495    
 Glu Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu
             500                 505                 510        
 Val Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu
         515                 520                 525            
 Thr Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu
     530                 535                 540                
 Lys Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu
 545                 550                 555                 560
 Leu Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu
                 565                 570                 575    
 Asn Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr
             580                 585                 590        
 Leu Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn
         595                 600                 605            
 Glu Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val
     610                 615                 620                
 Tyr Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser
 625                 630                 635                 640
 Leu Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp
                 645                 650                 655    
 Arg Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile
             660                 665                 670        
 Ala Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly
         675                 680                 685            
 Gln Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu
     690                 695                 700                
 Ser Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His
 705                 710                 715                 720
 Asn Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val
                 725                 730                 735    
 Leu Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp
             740                 745                 750        
 Leu Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp
         755                 760                 765            
 Ala Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn
     770                 775                 780                
 Thr Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala Ile Lys
 785                 790                 795                 800
 Lys Thr Ser Lys Lys Val Thr Arg Ala Phe Ser Phe Ser Lys Thr Pro
                 805                 810                 815    
 Lys Arg Ala Leu Arg Arg Ala Leu Met Thr Ser His Gly Ser Val Glu
             820                 825                 830        
 Gly Arg Ser Pro Ser Ser Asn Asp Lys His Val Met Ser Arg Leu Ser
         835                 840                 845            
 Ser Thr Ser Ser Leu Ala Gly Ile Pro Ser Pro Ser Leu Val Ser Leu
     850                 855                 860                
 Pro Ser Phe Phe Glu Arg Arg Ser His Thr Leu Ser Arg Ser Thr Thr
 865                 870                 875                 880
 His Leu Ile
            



      <210> 645
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 645
 Met Leu Leu Met Ala Ala Leu Trp Gly Leu Tyr Met Ser Leu Val Asn
   1               5                  10                  15    
 Val Gly His Val Trp Tyr Ser Phe Gly Trp Glu Ser Gln Leu Leu Glu
              20                  25                  30        
 Thr Gly Phe Leu Gly Ile Phe Leu Cys Pro Leu Trp Thr Leu Ser Arg
          35                  40                  45            
 Leu Pro Gln His Thr Pro Thr Ser Arg Ile Val Leu Trp Gly Phe Arg
      50                  55                  60                
 Trp Leu Ile Phe Arg Ile Met Leu Gly Ala Gly Leu Ile Lys Ile Arg
  65                  70                  75                  80
 Gly Asp Arg Cys Trp Arg Asp Leu Thr Cys Met Asp Phe His Tyr Glu
                  85                  90                  95    
 Thr Gln Pro Met Pro Asn Pro Val Ala Tyr Tyr Leu His His Ser Pro
             100                 105                 110        
 Trp Trp Phe His Arg Phe Glu Thr Leu Ser Asn His Phe Ile Glu Leu
         115                 120                 125            
 Leu Val Pro Phe Phe Leu Phe Leu Gly Arg Arg Ala Cys Ile Ile His
     130                 135                 140                
 Gly Val Leu Gln Ile Leu Phe Gln Ala Val Leu Ile Val Ser Gly Asn
 145                 150                 155                 160
 Leu Ser Phe Leu Asn Trp Leu Thr Met Val Pro Ser Leu Ala Cys Phe
                 165                 170                 175    
 Asp Asp Ala Thr Leu Gly Phe Leu Phe Pro Ser Gly Pro Gly Ser Leu
             180                 185                 190        
 Lys Asp Arg Val Leu Gln Met Gln Arg Asp Ile Arg Gly Ala Arg Pro
         195                 200                 205            
 Glu Pro Arg Phe Gly Ser Val Val Arg Arg Ala Ala Asn Val Ser Leu
     210                 215                 220                
 Gly Val Leu Leu Ala Trp Leu Ser Val Pro Val Val Leu Asn Leu Leu
 225                 230                 235                 240
 Ser Ser Arg Gln Val Met Asn Thr His Phe Asn Ser Leu His Ile Val
                 245                 250                 255    
 Asn Thr Tyr Gly Ala Phe Gly Ser Ile Thr Lys Glu Arg Ala Glu Val
             260                 265                 270        
 Ile Leu Gln Gly Thr Ala Ser Ser Asn Ala Ser Ala Pro Asp Ala Met
         275                 280                 285            
 Trp Glu Asp Tyr Glu Phe Lys Cys Lys Pro Asp Leu Arg Ala Gln Arg
     290                 295                 300                
 Leu Asp His Pro Pro Gly Trp Gln Ala Pro Gly Gln Arg Arg Arg Gly
 305                 310                 315                 320
 Leu Val Pro Ala Gly Thr Gln Pro Leu Arg Gly Gln Ala Pro Ala Gln
                 325                 330                 335    
 Val Gly Pro Arg Arg Ala Leu Gln Val Gln Val Gln Pro Ser Trp Gly
             340                 345                 350        
 Gln Ala Arg Arg Arg Gly Gln Val Val Gly Ala Glu Glu Asp Arg Ser
         355                 360                 365            
 Leu Leu Pro Ser Ala Gln Pro Gly Gly Ala Glu Ala Leu Leu Gln Gly
     370                 375                 380                
 Pro Trp Val Ala Ser Ala Arg Ala Pro Leu Asp Val His Gln Lys
 385                 390                 395                



      <210> 646
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 646
 Met Asn Gly Thr Ala Asn Pro Leu Leu Asp Arg Glu Glu His Cys Leu
   1               5                  10                  15    
 Arg Leu Gly Glu Ser Phe Glu Lys Arg Pro Arg Ala Ser Phe His Thr
              20                  25                  30        
 Ile Arg Tyr Asp Phe Lys Pro Ala Ser Ile Asp Thr Ser Cys Glu Gly
          35                  40                  45            
 Glu Leu Gln Val Gly Lys Gly Asp Glu Val Thr Ile Thr Leu Pro His
      50                  55                  60                
 Ile Pro Gly Ser Thr Pro Pro Met Thr Val Phe Lys Gly Asn Lys Arg
  65                  70                  75                  80
 Pro Tyr Gln Lys Asp Cys Val Leu Ile Ile Asn His Asp Thr Gly Glu
                  85                  90                  95    
 Tyr Val Leu Glu Lys Leu Ser Ser Ser Ile Gln Val Lys Lys Thr Arg
             100                 105                 110        
 Ala Glu Gly Ser Ser Lys Ile Gln Ala Arg Met Glu Gln Gln Pro Thr
         115                 120                 125            
 Arg Pro Pro Gln Thr Ser Gln Pro Pro Pro Pro Pro Pro Pro Met Pro
     130                 135                 140                
 Phe Arg Ala Pro Thr Lys Pro Pro Val Gly Pro Lys Thr Ser Pro Leu
 145                 150                 155                 160
 Lys Asp Asn Pro Ser Pro Glu Pro Gln Leu Asp Asp Ile Lys Arg Glu
                 165                 170                 175    
 Leu Arg Ala Glu Val Asp Ile Ile Glu Gln Met Ser Ser Ser Ser Gly
             180                 185                 190        
 Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Asp Asp Ser
         195                 200                 205            
 Ser Ser Ser Gly Gly Glu Asp Asn Gly Pro Ala Ser Pro Pro Gln Pro
     210                 215                 220                
 Ser His Gln Gln Pro Tyr Asn Ser Arg Pro Ala Val Ala Asn Gly Thr
 225                 230                 235                 240
 Ser Arg Pro Gln Gly Ser Asn Gln Leu Met Asn Thr Leu Arg Asn Asp
                 245                 250                 255    
 Leu Gln Leu Ser Glu Ser Gly Ser Asp Ser Asp Asp
             260                 265            



      <210> 647
      <211> 469
      <212> PRT
      <213> Homo sapiens


      <400> 647
 Met Glu Leu Ile Ser Pro Thr Val Ile Ile Ile Leu Gly Cys Leu Ala
   1               5                  10                  15    
 Leu Phe Leu Leu Leu Gln Arg Lys Asn Leu Arg Arg Pro Pro Cys Ile
              20                  25                  30        
 Lys Gly Trp Ile Pro Trp Ile Gly Val Gly Phe Glu Phe Gly Lys Ala
          35                  40                  45            
 Pro Leu Glu Phe Ile Glu Lys Ala Arg Ile Lys Tyr Gly Pro Ile Phe
      50                  55                  60                
 Thr Val Phe Ala Met Gly Asn Arg Met Thr Phe Val Thr Glu Glu Glu
  65                  70                  75                  80
 Gly Ile Asn Val Phe Leu Lys Ser Lys Lys Val Asp Phe Glu Leu Ala
                  85                  90                  95    
 Val Gln Asn Ile Val Tyr Arg Thr Ala Ser Ile Pro Lys Asn Val Phe
             100                 105                 110        
 Leu Ala Leu His Glu Lys Leu Tyr Ile Met Leu Lys Gly Lys Met Gly
         115                 120                 125            
 Thr Val Asn Leu His Gln Phe Thr Gly Gln Leu Thr Glu Glu Leu His
     130                 135                 140                
 Glu Gln Leu Glu Asn Leu Gly Thr His Gly Thr Met Asp Leu Asn Asn
 145                 150                 155                 160
 Leu Val Arg His Leu Leu Tyr Pro Val Thr Val Asn Met Leu Phe Asn
                 165                 170                 175    
 Lys Ser Leu Phe Ser Thr Asn Lys Lys Lys Ile Lys Glu Phe His Gln
             180                 185                 190        
 Tyr Phe Gln Val Tyr Asp Glu Asp Phe Glu Tyr Gly Ser Gln Leu Pro
         195                 200                 205            
 Glu Cys Leu Leu Arg Asn Trp Ser Lys Ser Lys Lys Trp Phe Leu Glu
     210                 215                 220                
 Leu Phe Glu Lys Asn Ile Pro Asp Ile Lys Ala Cys Lys Ser Ala Lys
 225                 230                 235                 240
 Asp Asn Ser Met Thr Leu Leu Gln Ala Thr Leu Asp Ile Val Glu Thr
                 245                 250                 255    
 Glu Thr Ser Lys Glu Asn Ser Pro Asn Tyr Gly Leu Leu Leu Leu Trp
             260                 265                 270        
 Ala Ser Leu Ser Asn Ala Val Pro Val Ala Phe Trp Thr Leu Ala Tyr
         275                 280                 285            
 Val Leu Ser His Pro Asp Ile His Lys Ala Ile Met Glu Gly Ile Ser
     290                 295                 300                
 Ser Val Phe Gly Lys Ala Gly Lys Asp Lys Ile Lys Val Ser Glu Asp
 305                 310                 315                 320
 Asp Leu Glu Lys Leu Leu Leu Ile Lys Trp Cys Val Leu Glu Thr Ile
                 325                 330                 335    
 Arg Leu Lys Ala Pro Gly Val Ile Thr Arg Lys Val Val Lys Pro Val
             340                 345                 350        
 Glu Ile Leu Asn Tyr Ile Ile Pro Ser Gly Asp Leu Leu Met Leu Ser
         355                 360                 365            
 Pro Phe Trp Leu His Arg Asn Pro Lys Tyr Phe Pro Glu Pro Glu Leu
     370                 375                 380                
 Phe Lys Pro Glu Arg Trp Lys Lys Ala Asn Leu Glu Lys His Ser Phe
 385                 390                 395                 400
 Leu Asp Cys Phe Met Ala Phe Gly Ser Gly Lys Phe Gln Cys Pro Ala
                 405                 410                 415    
 Arg Trp Phe Ala Leu Leu Glu Val Gln Met Cys Ile Ile Leu Ile Leu
             420                 425                 430        
 Tyr Lys Tyr Asp Cys Ser Leu Leu Asp Pro Leu Pro Lys Gln Ser Tyr
         435                 440                 445            
 Leu His Leu Val Gly Val Pro Gln Pro Glu Gly Gln Cys Arg Ile Glu
     450                 455                 460                
 Tyr Lys Gln Arg Ile
 465                



      <210> 648
      <211> 327
      <212> PRT
      <213> Homo sapiens


      <400> 648
 Met Ala Ala Val Val Glu Val Glu Val Gly Gly Gly Ala Ala Gly Glu
   1               5                  10                  15    
 Arg Glu Leu Asp Glu Val Asp Met Ser Asp Leu Ser Pro Glu Glu Gln
              20                  25                  30        
 Trp Arg Val Glu His Ala Arg Met His Ala Lys His Arg Gly His Glu
          35                  40                  45            
 Ala Met His Ala Glu Met Val Leu Ile Leu Ile Ala Thr Leu Val Val
      50                  55                  60                
 Ala Gln Leu Leu Leu Val Gln Trp Lys Gln Arg His Pro Arg Ser Tyr
  65                  70                  75                  80
 Asn Met Val Thr Leu Phe Gln Met Trp Val Val Pro Leu Tyr Phe Thr
                  85                  90                  95    
 Val Lys Leu His Trp Trp Arg Phe Leu Val Ile Trp Ile Leu Phe Ser
             100                 105                 110        
 Ala Val Thr Ala Phe Val Thr Phe Arg Ala Thr Arg Lys Pro Leu Val
         115                 120                 125            
 Gln Thr Thr Pro Arg Leu Val Tyr Lys Trp Phe Leu Leu Ile Tyr Lys
     130                 135                 140                
 Ile Ser Tyr Ala Thr Gly Ile Val Gly Tyr Met Ala Val Met Phe Thr
 145                 150                 155                 160
 Leu Phe Gly Leu Asn Leu Leu Phe Lys Ile Lys Pro Glu Asp Ala Met
                 165                 170                 175    
 Asp Phe Gly Ile Ser Leu Leu Phe Tyr Gly Leu Tyr Tyr Gly Val Leu
             180                 185                 190        
 Glu Arg Asp Phe Ala Glu Met Cys Ala Asp Tyr Met Ala Ser Thr Ile
         195                 200                 205            
 Gly Phe Tyr Ser Glu Ser Gly Met Pro Thr Lys His Leu Ser Asp Ser
     210                 215                 220                
 Val Cys Ala Val Cys Gly Gln Gln Ile Phe Val Asp Val Ser Glu Glu
 225                 230                 235                 240
 Gly Ile Ile Glu Asn Thr Tyr Arg Leu Ser Cys Asn His Val Phe His
                 245                 250                 255    
 Glu Phe Cys Ile Arg Gly Trp Cys Ile Val Gly Lys Lys Gln Thr Cys
             260                 265                 270        
 Pro Tyr Cys Lys Glu Lys Val Asp Leu Lys Arg Met Phe Ser Asn Pro
         275                 280                 285            
 Trp Glu Arg Pro His Val Met Tyr Gly Gln Leu Leu Asp Trp Leu Arg
     290                 295                 300                
 Tyr Leu Val Ala Trp Gln Pro Val Ile Ile Gly Val Val Gln Gly Ile
 305                 310                 315                 320
 Asn Tyr Ile Leu Gly Leu Glu
                 325        



      <210> 649
      <211> 985
      <212> PRT
      <213> Homo sapiens


      <400> 649
 Met Asn His Asp Phe Gln Ala Leu Ala Leu Glu Ser Arg Gly Met Gly
   1               5                  10                  15    
 Glu Leu Leu Pro Thr Lys Lys Phe Trp Glu Pro Asp Asp Ser Thr Lys
              20                  25                  30        
 Asp Gly Gln Lys Gly Ile Phe Leu Gly Asp Asp Glu Trp Arg Glu Thr
          35                  40                  45            
 Ala Trp Gly Ala Ser His His Ser Met Ser Gln Pro Ile Met Val Gln
      50                  55                  60                
 Arg Arg Ser Gly Gln Gly Phe His Gly Asn Ser Glu Val Asn Ala Ile
  65                  70                  75                  80
 Leu Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu
                  85                  90                  95    
 Tyr Val Leu Ser Ser Ser Pro Ala Asp Lys Leu Asp Ser Arg Phe Arg
             100                 105                 110        
 Lys Gly Asn Phe Gly Thr Arg Asp Ala Glu Thr Asp Gly Pro Glu Lys
         115                 120                 125            
 Gly Asp Gln Lys Gly Lys Ala Ser Pro Phe Glu Glu Asp Gln Asn Arg
     130                 135                 140                
 Asp Leu Lys Gln Gly Asp Asp Asp Asp Ser Lys Ile Asn Gly Arg Gly
 145                 150                 155                 160
 Leu Pro Asn Gly Met Asp Ala Asp Cys Lys Asp Phe Asn Arg Thr Pro
                 165                 170                 175    
 Gly Ser Arg Gln Ala Ser Pro Thr Glu Val Val Glu Arg Leu Gly Pro
             180                 185                 190        
 Asn Thr Asn Pro Ser Glu Gly Leu Gly Pro Leu Pro Asn Pro Thr Ala
         195                 200                 205            
 Asn Lys Pro Leu Val Glu Glu Phe Ser Asn Pro Glu Thr Gln Asn Leu
     210                 215                 220                
 Asp Ala Met Glu Gln Val Gly Leu Glu Ser Leu Gln Phe Asp Tyr Pro
 225                 230                 235                 240
 Gly Asn Gln Val Pro Met Asp Ser Ser Gly Ala Thr Val Gly Leu Phe
                 245                 250                 255    
 Asp Tyr Asn Ser Gln Gln Gln Leu Phe Gln Arg Thr Asn Ala Leu Thr
             260                 265                 270        
 Val Gln Gln Leu Thr Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala
         275                 280                 285            
 Ala Gln Gln Pro His Ile Ala Gly Val Phe Ser Ala Gly Leu Ala Pro
     290                 295                 300                
 Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser Ala Ala Pro Pro Gly
 305                 310                 315                 320
 Thr Asp Pro Tyr Thr Ala Ala Gly Leu Ala Ala Ala Ala Thr Leu Ala
                 325                 330                 335    
 Gly Pro Ala Val Val Pro Pro Gln Tyr Tyr Gly Val Pro Trp Gly Val
             340                 345                 350        
 Tyr Pro Ala Asn Leu Phe Gln Gln Gln Ala Ala Ala Ala Ala Asn Asn
         355                 360                 365            
 Thr Ala Ser Gln Gln Ala Ala Ser Gln Ala Gln Pro Gly Gln Gln Gln
     370                 375                 380                
 Val Leu Arg Ala Gly Ala Gly Gln Arg Pro Leu Thr Pro Asn Gln Gly
 385                 390                 395                 400
 Gln Gln Gly Gln Gln Ala Glu Ser Leu Ala Ala Ala Ala Ala Ala Asn
                 405                 410                 415    
 Pro Thr Leu Ala Phe Gly Gln Gly Leu Ala Thr Gly Met Pro Gly Tyr
             420                 425                 430        
 Gln Val Leu Ala Pro Thr Ala Tyr Tyr Asp Gln Thr Gly Ala Leu Val
         435                 440                 445            
 Val Gly Pro Gly Ala Arg Thr Gly Leu Gly Ala Pro Val Arg Leu Met
     450                 455                 460                
 Ala Pro Thr Pro Val Leu Ile Ser Ser Ala Ala Ala Gln Ala Ala Ala
 465                 470                 475                 480
 Ala Ala Ala Ala Gly Gly Thr Ala Ser Ser Leu Thr Gly Ser Thr Asn
                 485                 490                 495    
 Gly Leu Phe Arg Pro Ile Gly Thr Gln Pro Pro Gln Gln Gln Gln Gln
             500                 505                 510        
 Gln Pro Ser Thr Asn Leu Gln Ser Asn Ser Phe Tyr Gly Ser Ser Ser
         515                 520                 525            
 Leu Thr Asn Ser Ser Gln Ser Ser Ser Leu Phe Ser His Gly Pro Gly
     530                 535                 540                
 Gln Pro Gly Ser Thr Ser Leu Gly Phe Gly Ser Gly Asn Ser Leu Gly
 545                 550                 555                 560
 Ala Ala Ile Gly Ser Ala Leu Ser Gly Phe Gly Ser Ser Gly Gly Leu
                 565                 570                 575    
 Thr Asn Gly Ser Gly Arg Tyr Ile Ser Ala Ala Pro Gly Ala Glu Ala
             580                 585                 590        
 Lys Tyr Arg Ser Ala Ser Ser Thr Ser Ser Leu Phe Ser Ser Ser Ser
         595                 600                 605            
 Gln Leu Phe Pro Pro Ser Arg Leu Arg Tyr Asn Arg Ser Asp Ile Met
     610                 615                 620                
 Pro Ser Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Phe
 625                 630                 635                 640
 Pro Asn Leu Gln Leu Arg Asp Leu Ile Gly His Ile Val Glu Phe Ser
                 645                 650                 655    
 Gln Asp Gln His Gly Ser Arg Phe Ile Gln Gln Lys Leu Glu Arg Ala
             660                 665                 670        
 Thr Pro Ala Glu Arg Gln Met Val Phe Asn Glu Ile Leu Gln Ala Ala
         675                 680                 685            
 Tyr Gln Leu Met Thr Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe
     690                 695                 700                
 Phe Glu Phe Gly Ser Leu Asp Gln Lys Leu Ala Leu Ala Thr Arg Ile
 705                 710                 715                 720
 Arg Gly His Val Leu Pro Leu Ala Leu Gln Met Tyr Gly Cys Arg Val
                 725                 730                 735    
 Ile Gln Lys Ala Leu Glu Ser Ile Ser Ser Asp Gln Gln Ser Glu Met
             740                 745                 750        
 Val Lys Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn
         755                 760                 765            
 Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser
     770                 775                 780                
 Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Val Leu Ser
 785                 790                 795                 800
 Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys
                 805                 810                 815    
 Thr Ala Glu Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr
             820                 825                 830        
 Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val
         835                 840                 845            
 Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ser Glu Ile
     850                 855                 860                
 Arg Gly Lys Val Leu Ala Leu Ser Gln His Lys Phe Ala Ser Asn Val
 865                 870                 875                 880
 Val Glu Lys Cys Val Thr His Ala Ser Arg Ala Glu Arg Ala Leu Leu
                 885                 890                 895    
 Ile Asp Glu Val Cys Cys Gln Asn Asp Gly Pro His Ser Ala Leu Tyr
             900                 905                 910        
 Thr Met Met Lys Ala Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile
         915                 920                 925            
 Asp Met Ala Glu Pro Ala Gln Arg Lys Ile Ile Met His Lys Ile Arg
     930                 935                 940                
 Pro His Ile Thr Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu
 945                 950                 955                 960
 Ala Lys Leu Glu Lys Tyr Tyr Leu Lys Asn Ser Pro Asp Leu Gly Pro
                 965                 970                 975    
 Ile Gly Gly Pro Pro Asn Gly Met Leu
             980                 985



      <210> 650
      <211> 325
      <212> PRT
      <213> Homo sapiens


      <400> 650
 Met Thr Glu Arg Arg Arg Asp Glu Leu Ser Glu Glu Ile Asn Asn Leu
   1               5                  10                  15    
 Arg Glu Lys Val Met Lys Gln Ser Glu Glu Asn Asn Asn Leu Gln Ser
              20                  25                  30        
 Gln Val Gln Lys Leu Thr Glu Glu Asn Thr Thr Leu Arg Glu Gln Val
          35                  40                  45            
 Glu Pro Thr Pro Glu Asp Glu Asp Asp Asp Ile Glu Leu Arg Gly Ala
      50                  55                  60                
 Ala Ala Ala Ala Ala Pro Pro Pro Pro Ile Glu Glu Glu Cys Pro Glu
  65                  70                  75                  80
 Asp Leu Pro Glu Lys Phe Asp Gly Asn Pro Asp Met Leu Ala Pro Phe
                  85                  90                  95    
 Met Ala Gln Cys Gln Ile Phe Met Glu Lys Ser Thr Arg Asp Phe Ser
             100                 105                 110        
 Val Asp Arg Val Arg Val Cys Phe Val Thr Ser Met Met Thr Gly Arg
         115                 120                 125            
 Ala Ala Arg Trp Ala Ser Ala Lys Leu Glu Arg Ser His Tyr Leu Met
     130                 135                 140                
 His Asn Tyr Pro Ala Phe Met Met Glu Met Lys His Val Phe Glu Asp
 145                 150                 155                 160
 Pro Gln Arg Arg Glu Val Ala Lys Arg Lys Ile Arg Arg Leu Arg Gln
                 165                 170                 175    
 Gly Met Gly Ser Val Ile Asp Tyr Ser Asn Ala Phe Gln Met Ile Ala
             180                 185                 190        
 Gln Asp Leu Asp Trp Asn Glu Pro Ala Leu Ile Asp Gln Tyr His Glu
         195                 200                 205            
 Gly Leu Ser Asp His Ile Gln Glu Glu Leu Ser His Leu Glu Val Ala
     210                 215                 220                
 Lys Ser Leu Ser Ala Leu Ile Gly Gln Cys Ile His Ile Glu Arg Arg
 225                 230                 235                 240
 Leu Ala Arg Ala Ala Ala Ala Arg Lys Pro Arg Ser Pro Pro Arg Ala
                 245                 250                 255    
 Leu Val Leu Pro His Ile Ala Ser His His Gln Val Asp Pro Thr Glu
             260                 265                 270        
 Pro Val Gly Gly Ala Arg Met Arg Leu Thr Gln Glu Glu Lys Glu Arg
         275                 280                 285            
 Arg Arg Lys Leu Asn Leu Cys Leu Tyr Cys Gly Thr Gly Gly His Tyr
     290                 295                 300                
 Ala Asp Asn Cys Pro Ala Lys Ala Ser Lys Ser Ser Pro Ala Gly Asn
 305                 310                 315                 320
 Ser Pro Ala Pro Leu
                 325



      <210> 651
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 651
 Met Ser Ser Val Lys Arg Ser Leu Lys Gln Glu Ile Val Thr Gln Phe
   1               5                  10                  15    
 His Cys Ser Ala Ala Glu Gly Asp Ile Ala Lys Leu Thr Gly Ile Leu
              20                  25                  30        
 Ser His Ser Pro Ser Leu Leu Asn Glu Thr Ser Glu Asn Gly Trp Thr
          35                  40                  45            
 Ala Leu Met Tyr Ala Ala Arg Asn Gly His Pro Glu Ile Val Gln Phe
      50                  55                  60                
 Leu Leu Glu Lys Gly Cys Asp Arg Ser Ile Val Asn Lys Ser Arg Gln
  65                  70                  75                  80
 Thr Ala Leu Asp Ile Ala Ile Phe Trp Gly Tyr Lys His Ile Ala Asn
                  85                  90                  95    
 Leu Leu Ala Thr Ala Lys Gly Gly Lys Lys Pro Trp Phe Leu Thr Asn
             100                 105                 110        
 Glu Val Glu Glu Cys Glu Asn Tyr Phe Ser Lys Thr Leu Leu Asp Arg
         115                 120                 125            
 Lys Ser Glu Lys Arg Asn Asn Ser Asp Trp Leu Leu Ala Lys Glu Ser
     130                 135                 140                
 His Pro Ala Thr Val Phe Ile Leu Phe Ser Asp Leu Asn Pro Leu Val
 145                 150                 155                 160
 Thr Leu Gly Gly Asn Lys Glu Ser Phe Gln Gln Pro Glu Val Arg Leu
                 165                 170                 175    
 Cys Gln Leu Asn Tyr Thr Asp Ile Lys Asp Tyr Leu Ala Gln Pro Glu
             180                 185                 190        
 Lys Ile Thr Leu Ile Phe Leu Gly Val Glu Leu Glu Ile Lys Asp Lys
         195                 200                 205            
 Leu Leu Asn Tyr Ala Gly Glu Val Pro Arg Glu Glu Glu Asp Gly Leu
     210                 215                 220                
 Val Ala Trp Phe Ala Leu Gly Ile Asp Pro Ile Ala Ala Glu Glu Phe
 225                 230                 235                 240
 Lys Gln Arg His Glu Asn Cys Tyr Phe Leu His Pro Pro Met Pro Ala
                 245                 250                 255    
 Leu Leu Gln Leu Lys Glu Lys Glu Ala Gly Lys Lys
             260                 265            



      <210> 652
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 652
 Met Trp Arg Ala Leu Lys Asn Pro Thr Ala His Pro Val Trp Ser Thr
   1               5                  10                  15    
 Gly Pro Pro Arg Val Trp Gly Ala Asp Arg Ser Thr Leu Arg Ala Val
              20                  25                  30        
 Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr
          35                  40                  45            
 Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu
      50                  55                  60                
 Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val
  65                  70                  75                  80
 Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val
                  85                  90                  95    
 Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln
             100                 105                 110        
 Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp
         115                 120                 125            
 Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val
     130                 135                 140                
 Gly
 145



      <210> 653
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 653
 Met Ala Gly Lys Val Lys Trp Val Thr Asp Ile Glu Lys Ser Val Leu
   1               5                  10                  15    
 Ile Asn Asn Phe Glu Lys Arg Gly Trp Val Gln Val Thr Glu Asn Glu
              20                  25                  30        
 Asp Trp Asn Phe Tyr Trp Met Ser Val Gln Thr Ile Arg Asn Val Phe
          35                  40                  45            
 Ser Val Glu Ala Gly Tyr Arg Leu Ser Asp Asp Gln Ile Val Asn His
      50                  55                  60                
 Phe Pro Asn His Tyr Glu Leu Thr Arg Lys Asp Leu Met Val Lys Asn
  65                  70                  75                  80
 Ile Lys Arg Tyr Arg Lys Glu Leu Glu Lys Glu Gly Ser Pro Leu Ala
                  85                  90                  95    
 Glu Lys Asp Glu Asn Gly Lys Tyr Leu Tyr Leu Asp Phe Val Pro Val
             100                 105                 110        
 Thr Tyr Met Leu Pro Ala Asp Tyr Asn Leu Phe Val Glu Glu Phe Arg
         115                 120                 125            
 Lys Ser Pro Ser Ser Thr Trp Ile Met Lys Pro Cys Gly Lys Ala Gln
     130                 135                 140                
 Gly Lys Gly Ile Phe Leu Ile Asn Lys Leu Ser Gln Ile Lys Lys Trp
 145                 150                 155                 160
 Ser Arg Asp Ser Lys Thr Ser Ser Phe Val Ser Gln Ser Asn Lys Glu
                 165                 170                 175    
 Ala Tyr Val Ile Ser Leu Tyr Ile Asn Asn Pro Leu Leu Ile Gly Gly
             180                 185                 190        
 Arg Lys Phe Asp Leu Arg Leu Tyr Val Leu Val Ser Thr Tyr Arg Pro
         195                 200                 205            
 Leu Arg Cys Tyr Met Tyr Lys Leu Gly Phe Cys Arg Phe Cys Thr Val
     210                 215                 220                
 Lys Tyr Thr Pro Ser Thr Ser Glu Leu Asp Asn Met Phe Val His Leu
 225                 230                 235                 240
 Thr Asn Val Ala Ile Gln Lys His Gly Glu Asp Tyr Asn His Ile His
                 245                 250                 255    
 Gly Gly Lys Trp Thr Val Ser Asn Leu Arg Leu Tyr Leu Glu Ser Thr
             260                 265                 270        
 Arg Gly Lys Glu Val Thr Ser Lys Leu Phe Asp Glu Ile His Trp Ile
         275                 280                 285            
 Ile Val Gln Ser Leu Lys Ala Val Ala Pro Val Met Asn Asn Asp Lys
     290                 295                 300                
 His Cys Phe Glu Cys Tyr Gly Tyr Asp Ile Ile Ile Asp Asp Lys Leu
 305                 310                 315                 320
 Lys Pro Trp Leu Ile Glu Val Asn Ala Ser Pro Ser Leu Thr Ser Ser
                 325                 330                 335    
 Thr Ala Asn Asp Arg Ile Leu Lys Tyr Asn Leu Ile Asn Asp Thr Leu
             340                 345                 350        
 Asn Ile Ala Val Pro Asn Gly Glu Ile Pro Asp Cys Lys Trp Asn Lys
         355                 360                 365            
 Ser Pro Pro Lys Glu Val Leu Gly Asn Tyr Glu Ile Leu Tyr Asp Glu
     370                 375                 380                
 Glu Leu Ala Gln Gly Asp Gly Ala Asp Arg Glu Leu Arg Ser Arg Gln
 385                 390                 395                 400
 Gly Gln Ser Leu Gly Pro Arg Ala Gly Arg Ser Arg Asp Ser Gly Arg
                 405                 410                 415    
 Ala Val Leu Thr Thr Trp Lys
             420            



      <210> 654
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 654
 Met Ser Phe Val Ala Tyr Glu Glu Leu Ile Lys Glu Gly Asp Thr Ala
   1               5                  10                  15    
 Ile Leu Ser Leu Gly His Gly Ala Met Val Ala Val Arg Val Gln Arg
              20                  25                  30        
 Gly Ala Gln Thr Gln Thr Arg His Gly Val Leu Arg His Ser Val Asp
          35                  40                  45            
 Leu Ile Gly Arg Pro Phe Gly Ser Lys Val Thr Cys Gly Arg Gly Gly
      50                  55                  60                
 Trp Val Tyr Val Leu His Pro Thr Pro Glu Leu Trp Thr Leu Asn Leu
  65                  70                  75                  80
 Pro His Arg Thr Gln Ile Leu Tyr Ser Thr Asp Ile Ala Leu Ile Thr
                  85                  90                  95    
 Met Met Leu Glu Leu Arg Pro Gly Ser Val Val Cys Glu Ser Gly Thr
             100                 105                 110        
 Gly Ser Gly Ser Val Ser His Ala Ile Ile Arg Thr Ile Ala Pro Thr
         115                 120                 125            
 Gly His Leu His Thr Val Glu Phe His Gln Gln Arg Ala Glu Lys Ala
     130                 135                 140                
 Arg Glu Glu Phe Gln Glu His Arg Val Gly Arg Trp Val Thr Val Arg
 145                 150                 155                 160
 Thr Gln Asp Val Cys Arg Ser Gly Phe Gly Val Ser His Val Ala Asp
                 165                 170                 175    
 Ala Val Phe Leu Asp Ile Pro Ser Pro Trp Glu Ala Val Gly His Ala
             180                 185                 190        
 Trp Asp Ala Leu Lys Val Glu Gly Gly Arg Phe Cys Ser Phe Ser Pro
         195                 200                 205            
 Cys Ile Glu Gln Val Gln Arg Thr Cys Gln Ala Leu Ala Ala Arg Gly
     210                 215                 220                
 Phe Ser Glu Leu Ser Thr Leu Glu Val Leu Pro Gln Val Tyr Asn Val
 225                 230                 235                 240
 Arg Thr Val Ser Leu Pro Pro Pro Asp Leu Gly Thr Gly Thr Asp Gly
                 245                 250                 255    
 Pro Ala Gly Ser Asp Thr Ser Pro Phe Arg Ser Gly Thr Pro Met Lys
             260                 265                 270        
 Glu Ala Val Gly His Thr Gly Tyr Leu Thr Phe Ala Thr Lys Thr Pro
         275                 280                 285            
 Gly
    



      <210> 655
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 655
 Met Ala Ala Gly Gly Leu Ser Arg Ser Glu Arg Lys Ala Ala Glu Arg
   1               5                  10                  15    
 Val Arg Arg Leu Arg Glu Glu Gln Gln Arg Glu Arg Leu Arg Gln Val
              20                  25                  30        
 Ser Arg Ile Leu Arg Lys Ala Ala Ala Glu Arg Ser Ala Glu Glu Gly
          35                  40                  45            
 Arg Leu Leu Ala Glu Ser Ala Asp Leu Val Thr Glu Leu Gln Gly Arg
      50                  55                  60                
 Ser Arg Arg Arg Glu Gly Leu Lys Arg Arg Gln Glu Glu Val Cys Asp
  65                  70                  75                  80
 Asp Pro Glu Glu Leu Arg Gly Lys Val Arg Glu Leu Ala Ser Ala Val
                  85                  90                  95    
 Arg Asn Ala Lys Tyr Leu Val Val Tyr Thr Gly Ala Gly Ile Ser Thr
             100                 105                 110        
 Ala Ala Ser Ile Pro Asp Tyr Arg Gly Pro Asn Gly Val Trp Thr Leu
         115                 120                 125            
 Leu Gln Lys Gly Arg Ser Val Ser Ala Ala Asp Leu Ser Glu Ala Glu
     130                 135                 140                
 Pro Thr Leu Thr His Met Ser Ile Thr Arg Leu His Glu Gln Lys Leu
 145                 150                 155                 160
 Val Gln His Val Val Ser Gln Asn Cys Asp Gly Leu His Leu Arg Ser
                 165                 170                 175    
 Gly Leu Pro Arg Thr Ala Ile Ser Glu Leu His Gly Asn Met Tyr Ile
             180                 185                 190        
 Glu Val Cys Thr Ser Cys Val Pro Asn Arg Glu Tyr Val Arg Val Phe
         195                 200                 205            
 Asp Val Thr Glu Arg Thr Ala Leu His Arg His Gln Thr Gly Arg Thr
     210                 215                 220                
 Cys His Lys Cys Gly Thr Gln Leu Arg Asp Thr Ile Val His Phe Gly
 225                 230                 235                 240
 Glu Arg Gly Thr Leu Gly Gln Pro Leu Asn Trp Glu Ala Ala Thr Glu
                 245                 250                 255    
 Ala Ala Ser Arg Ala Asp Thr Ile Leu Cys Leu Gly Ser Ser Leu Lys
             260                 265                 270        
 Val Leu Lys Lys Tyr Pro Arg Leu Trp Cys Met Thr Lys Pro Pro Ser
         275                 280                 285            
 Arg Arg Pro Lys Leu Tyr Ile Val Asn Leu Gln Trp Thr Pro Lys Asp
     290                 295                 300                
 Asp Trp Ala Ala Leu Lys Leu His Gly Lys Cys Asp Asp Val Met Arg
 305                 310                 315                 320
 Leu Leu Met Ala Glu Leu Gly Leu Glu Ile Pro Ala Tyr Ser Arg Trp
                 325                 330                 335    
 Gln Asp Pro Ile Phe Ser Leu Ala Thr Pro Leu Arg Ala Gly Glu Glu
             340                 345                 350        
 Gly Ser His Ser Arg Lys Ser Leu Cys Arg Ser Arg Glu Glu Ala Pro
         355                 360                 365            
 Pro Gly Asp Arg Gly Ala Pro Leu Ser Ser Ala Pro Ile Leu Gly Gly
     370                 375                 380                
 Trp Phe Gly Arg Gly Cys Thr Lys Arg Thr Lys Arg Lys Lys Val Thr
 385                 390                 395                 400





      <210> 656
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 656
 Met Asp Ala Pro His Ser Lys Ala Ala Leu Asp Ser Ile Asn Glu Leu
   1               5                  10                  15    
 Pro Glu Asn Ile Leu Leu Glu Leu Phe Thr His Val Pro Ala Arg Gln
              20                  25                  30        
 Leu Leu Leu Asn Cys Arg Leu Val Cys Ser Leu Trp Arg Asp Leu Ile
          35                  40                  45            
 Asp Leu Met Thr Leu Trp Lys Arg Lys Cys Leu Arg Glu Gly Phe Ile
      50                  55                  60                
 Thr Lys Asp Trp Asp Gln Pro Val Ala Asp Trp Lys Ile Phe Tyr Phe
  65                  70                  75                  80
 Leu Arg Ser Leu His Arg Asn Leu Leu Arg Asn Pro Cys Ala Glu Glu
                  85                  90                  95    
 Asp Met Phe Ala Trp Gln Ile Asp Phe Asn Gly Gly Asp Arg Trp Lys
             100                 105                 110        
 Val Glu Ser Leu Pro Gly Ala His Gly Thr Asp Phe Pro Asp Pro Lys
         115                 120                 125            
 Val Lys Lys Tyr Phe Val Thr Ser Tyr Glu Met Cys Leu Lys Ser Gln
     130                 135                 140                
 Leu Val Asp Leu Val Ala Glu Gly Tyr Trp Glu Glu Leu Leu Asp Thr
 145                 150                 155                 160
 Phe Arg Pro Asp Ile Val Val Lys Asp Trp Phe Ala Ala Arg Ala Asp
                 165                 170                 175    
 Cys Gly Cys Thr Tyr Gln Leu Lys Val Gln Leu Ala Ser Ala Asp Tyr
             180                 185                 190        
 Phe Val Leu Ala Ser Phe Glu Pro Pro Pro Val Thr Ile Gln Gln Trp
         195                 200                 205            
 Asn Asn Ala Thr Trp Thr Glu Val Ser Tyr Thr Phe Ser Asp Tyr Pro
     210                 215                 220                
 Arg Gly Val Arg Tyr Ile Leu Phe Gln His Gly Gly Arg Asp Thr Gln
 225                 230                 235                 240
 Tyr Trp Ala Gly Trp Tyr Gly Pro Arg Val Thr Asn Ser Ser Ile Val
                 245                 250                 255    
 Val Ser Pro Lys Met Thr Arg Asn Gln Ala Ser Ser Glu Ala Gln Pro
             260                 265                 270        
 Gly Gln Lys His Gly Gln Glu Glu Ala Ala Gln Ser Pro Tyr Arg Ala
         275                 280                 285            
 Val Val Gln Ile Phe
     290            



      <210> 657
      <211> 516
      <212> PRT
      <213> Homo sapiens


      <400> 657
 Met Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Ser
   1               5                  10                  15    
 Asp Cys Gly Lys Ala Phe Thr Phe Lys Ser Gln Leu Ile Val His Gln
              20                  25                  30        
 Gly Ile His Thr Gly Val Lys Pro Tyr Gly Cys Ile Gln Cys Gly Lys
          35                  40                  45            
 Gly Phe Ser Leu Lys Ser Gln Leu Ile Val His Gln Arg Ser His Thr
      50                  55                  60                
 Gly Met Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Arg Ser
  65                  70                  75                  80
 Lys Ser Tyr Leu Ile Ile His Thr Arg Thr His Thr Gly Glu Lys Leu
                  85                  90                  95    
 His Glu Cys Asn Asn Cys Gly Lys Ala Phe Ser Phe Lys Ser Gln Leu
             100                 105                 110        
 Ile Ile His Gln Arg Ile His Thr Gly Glu Asn Pro Tyr Glu Cys His
         115                 120                 125            
 Glu Cys Gly Lys Ala Phe Ser Arg Lys Tyr Gln Leu Ile Ser His Gln
     130                 135                 140                
 Arg Thr His Ala Gly Glu Lys Pro Tyr Glu Cys Thr Asp Cys Gly Lys
 145                 150                 155                 160
 Ala Phe Gly Leu Lys Ser Gln Leu Ile Ile His Gln Arg Thr His Thr
                 165                 170                 175    
 Gly Glu Lys Pro Phe Glu Cys Ser Glu Cys Gln Lys Ala Phe Asn Thr
             180                 185                 190        
 Lys Ser Asn Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro
         195                 200                 205            
 Tyr Ser Cys Asn Glu Cys Gly Lys Ala Phe Thr Phe Lys Ser Gln Leu
     210                 215                 220                
 Ile Val His Lys Gly Val His Thr Gly Val Lys Pro Tyr Gly Cys Ser
 225                 230                 235                 240
 Gln Cys Ala Lys Thr Phe Ser Leu Lys Ser Gln Leu Ile Val His Gln
                 245                 250                 255    
 Arg Ser His Thr Gly Val Lys Pro Tyr Gly Cys Ser Glu Cys Gly Lys
             260                 265                 270        
 Ala Phe Arg Ser Lys Ser Tyr Leu Ile Ile His Met Arg Thr His Thr
         275                 280                 285            
 Gly Glu Lys Pro His Glu Cys Arg Glu Cys Gly Lys Ser Phe Ser Phe
     290                 295                 300                
 Asn Ser Gln Leu Ile Val His Gln Arg Ile His Thr Gly Glu Asn Pro
 305                 310                 315                 320
 Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Asn Arg Lys Asp Gln Leu
                 325                 330                 335    
 Ile Ser His Gln Arg Thr His Ala Gly Glu Lys Pro Tyr Gly Cys Ser
             340                 345                 350        
 Glu Cys Gly Lys Ala Phe Ser Ser Lys Ser Tyr Leu Ile Ile His Met
         355                 360                 365            
 Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys
     370                 375                 380                
 Ala Phe Ile Trp Lys Ser Leu Leu Ile Val His Glu Arg Thr His Ala
 385                 390                 395                 400
 Gly Val Asn Pro Tyr Lys Cys Ser Gln Cys Glu Lys Ser Phe Ser Gly
                 405                 410                 415    
 Lys Leu Arg Leu Leu Val His Gln Arg Met His Thr Thr Glu Lys Pro
             420                 425                 430        
 Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ile Arg Asn Ser Gln Leu
         435                 440                 445            
 Ile Val His Gln Arg Thr His Ser Gly Glu Lys Pro Tyr Gly Cys Asn
     450                 455                 460                
 Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser Ile Leu Ser Ala His Gln
 465                 470                 475                 480
 Arg Thr His Thr Gly Glu Lys Pro Cys Lys Cys Thr Glu Cys Gly Lys
                 485                 490                 495    
 Ala Phe Cys Trp Lys Ser Gln Leu Ile Met His Gln Arg Thr His Val
             500                 505                 510        
 Asp Asp Lys His
         515    



      <210> 658
      <211> 225
      <212> PRT
      <213> Homo sapiens


      <400> 658
 Met Ala Gly Lys Leu Ala Val Glu Arg Gly Trp Ala Ile Asn Val Gly
   1               5                  10                  15    
 Gly Gly Phe His His Cys Ser Ser Asp Arg Gly Gly Gly Phe Cys Ala
              20                  25                  30        
 Tyr Ala Asp Ile Thr Leu Ala Ile Lys Phe Leu Phe Glu Arg Val Glu
          35                  40                  45            
 Gly Ile Ser Arg Ala Thr Ile Ile Asp Leu Asp Ala His Gln Gly Asn
      50                  55                  60                
 Gly His Glu Arg Asp Phe Met Asp Asp Lys Arg Val Tyr Ile Met Asp
  65                  70                  75                  80
 Val Tyr Asn Arg His Ile Tyr Pro Gly Asp Arg Phe Ala Lys Gln Ala
                  85                  90                  95    
 Ile Arg Arg Lys Val Glu Leu Glu Trp Gly Thr Glu Asp Asp Glu Tyr
             100                 105                 110        
 Leu Asp Lys Val Glu Arg Asn Ile Lys Lys Ser Leu Gln Glu His Leu
         115                 120                 125            
 Pro Asp Val Val Val Tyr Asn Ala Gly Thr Asp Ile Leu Glu Gly Asp
     130                 135                 140                
 Arg Leu Gly Gly Leu Ser Ile Ser Pro Ala Gly Ile Val Lys Arg Asp
 145                 150                 155                 160
 Glu Leu Val Phe Arg Met Val Arg Gly Arg Arg Val Pro Ile Leu Met
                 165                 170                 175    
 Val Thr Ser Gly Gly Tyr Gln Lys Arg Thr Ala Arg Ile Ile Ala Asp
             180                 185                 190        
 Ser Ile Leu Asn Leu Phe Gly Leu Gly Leu Ile Gly Pro Glu Ser Pro
         195                 200                 205            
 Ser Val Ser Ala Gln Asn Ser Asp Thr Pro Leu Leu Pro Pro Ala Val
     210                 215                 220                
 Pro
 225



      <210> 659
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 659
 Met His Thr Glu Met Gln Ala Leu Arg Ala Asp Trp Lys Gln Trp Glu
   1               5                  10                  15    
 Asp Ser Val Phe Gln Thr Gln Ser Cys Leu Glu Asn Leu Val Ser Gln
              20                  25                  30        
 Met Ala Leu Ser Glu Gln Glu Phe Ser Gly Gln Val Ala Gln Leu Glu
          35                  40                  45            
 Gln Ala Leu Glu Gln Phe Ser Ala Leu Leu Lys Thr Trp Ala Gln Gln
      50                  55                  60                
 Leu Thr Leu Leu Glu Gly Lys Asn Thr Asp Glu Glu Ile Val Glu Cys
  65                  70                  75                  80
 Trp His Lys Gly Gln Glu Ile Leu Asp Ala Leu Gln Lys Ala Glu Pro
                  85                  90                  95    
 Arg Thr Glu Asp Leu Lys Ser Gln Leu Asn Glu Leu Cys Arg Phe Ser
             100                 105                 110        
 Arg Asp Leu Ser Thr Tyr Ser Gly Lys Val Ser Gly Leu Ile Lys Glu
         115                 120                 125            
 Tyr Asn Cys Leu Cys Leu Gln Ala Ser Lys Gly Cys Gln Asn Lys Glu
     130                 135                 140                
 Gln Ile Leu Gln Gln Arg Phe Arg Lys Ala Phe Arg Asp Phe Gln Gln
 145                 150                 155                 160
 Trp Leu Val Asn Ala Lys Ile Thr Thr Ala Lys Cys Phe Asp Ile Pro
                 165                 170                 175    
 Gln Asn Ile Ser Glu Val Ser Thr Ser Leu Gln Lys Ile Gln Glu Phe
             180                 185                 190        
 Leu Ser Lys Val Lys Met Cys Ser Thr Gly
         195                 200        



      <210> 660
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 660
 Met Met Asp Val Ser Glu Leu Gly Glu Ser Ala Arg Tyr Leu Arg Gln
   1               5                  10                  15    
 Gly Tyr Gln Glu Met Thr Lys Val His Thr Ile Pro Trp Asp Gly Lys
              20                  25                  30        
 Lys Arg Val Trp Val Pro Asp Glu Gln Asp Ala Tyr Val Glu Ala Glu
          35                  40                  45            
 Val Lys Ser Glu Ala Thr Gly Gly Arg Val Thr Val Glu Thr Lys Asp
      50                  55                  60                
 Gln Lys Val Leu Met Val Arg Glu Ala Glu Leu Gln Pro Met Asn Pro
  65                  70                  75                  80
 Pro Arg Phe Asp Leu Leu Glu Asp Met Ala Met Met Thr His Leu Asn
                  85                  90                  95    
 Glu Ala Ser Val Leu His Asn Leu Arg Gln Arg Tyr Ala Arg Trp Met
             100                 105                 110        
 Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Ile Asn Pro Tyr Lys
         115                 120                 125            
 Trp Leu Pro Val Tyr Thr Ala Ser Val Val Ala Ala Tyr Lys Gly Lys
     130                 135                 140                
 Arg Arg Ser Asp Ser Pro Pro His Ile Tyr Ala Val Ala Asp Asn Ala
 145                 150                 155                 160
 Tyr Asn Asp Met Leu Arg Asn Arg Asp Asn Gln Ser Met Leu Ile Thr
                 165                 170                 175    





      <210> 661
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 661
 Met Glu Cys Leu Val Ala Asp Lys Gln Asn Phe His Lys Ser Cys Phe
   1               5                  10                  15    
 Arg Cys His His Cys Asn Ser Lys Leu Ser Leu Gly Asn Tyr Ala Ser
              20                  25                  30        
 Leu His Gly Gln Ile Tyr Cys Lys Pro His Phe Lys Gln Leu Phe Lys
          35                  40                  45            
 Ser Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Lys Gln His Lys Asp
      50                  55                  60                
 Arg Trp Asn Cys Lys Asn Gln Ser Arg Ser Val Asp Phe Ile Pro Asn
  65                  70                  75                  80
 Glu Glu Pro Asn Met Cys Lys Asn Ile Ala Glu Asn Thr Leu Val Pro
                  85                  90                  95    
 Gly Asp Arg Asn Glu His Leu Asp Ala Gly Asn Ser Glu Gly Gln Arg
             100                 105                 110        
 Asn Asp Leu Arg Lys Leu Gly Glu Arg Gly Lys Leu Lys Val Ile Trp
         115                 120                 125            
 Pro Pro Ser Lys Glu Ile Pro Lys Lys Thr Leu Pro Phe Glu Glu Glu
     130                 135                 140                
 Leu Lys Met Ser Lys Pro Lys Trp Pro Pro Glu Met Thr Thr Leu Leu
 145                 150                 155                 160
 Ser Pro Glu Phe Lys Ser Glu Ser Leu Leu Glu Asp Val Arg Thr Pro
                 165                 170                 175    
 Glu Asn Lys Gly Gln Arg Gln Asp His Phe Pro Phe Leu Gln Pro Tyr
             180                 185                 190        
 Leu Gln Ser Thr His Val Cys Gln Lys Glu Asp Val Ile Gly Ile Lys
         195                 200                 205            
 Glu Met Lys Met Pro Glu Gly Arg Lys Asp Glu Lys Lys Glu Gly Arg
     210                 215                 220                
 Lys Asn Val Gln Asp Arg Pro Ser Glu Ala Glu Asp Thr Lys Ser Asn
 225                 230                 235                 240
 Arg Lys Ser Ala Met Asp Leu Asn Asp Asn Asn Asn Val Ile Val Gln
                 245                 250                 255    
 Ser Ala Glu Lys Glu Lys Asn Glu Lys Thr Asn Gln Thr Asn Gly Ala
             260                 265                 270        
 Glu Val Leu Gln Val Thr Asn Thr Asp Asp Glu Met Met Pro Glu Asn
         275                 280                 285            
 His Lys Glu Asn Leu Asn Lys Asn Asn Asn Asn Asn Tyr Val Ala Val
     290                 295                 300                
 Ser Tyr Leu Asn Asn Cys Arg Gln Lys Thr Ser Ile Leu Glu Phe Leu
 305                 310                 315                 320
 Asp Leu Leu Pro Leu Ser Ser Glu Ala Asn Asp Thr Ala Asn Glu Tyr
                 325                 330                 335    
 Glu Ile Glu Lys Leu Glu Asn Thr Ser Arg Ile Ser Glu Leu Leu Gly
             340                 345                 350        
 Ile Phe Glu Ser Glu Lys Thr Tyr Ser Arg Asn Val Leu Ala Met Ala
         355                 360                 365            
 Leu Lys Lys Gln Thr Asp Arg Ala Ala Ala Gly Ser Pro Val Gln Pro
     370                 375                 380                
 Ala Pro Lys Pro Ser Leu Ser Arg Gly Leu Met Val Lys Gly Gly Ser
 385                 390                 395                 400
 Ser Ile Ile Ser Pro Asp Thr Asn Leu Leu Asn Ile Lys Gly Ser His
                 405                 410                 415    
 Ser Lys Ser Lys Asn Leu His Phe Phe Phe Ser Asn Thr Val Lys Ile
             420                 425                 430        
 Thr Ala Phe Ser Lys Lys Asn Glu Asn Ile Phe Asn Cys Asp Leu Ile
         435                 440                 445            
 Asp Ser Val Asp Gln Ile Lys Asn Met Pro Cys Leu Asp Leu Arg Glu
     450                 455                 460                
 Phe Gly Lys Asp Val Lys Pro Trp His Val Glu Thr Thr Glu Ala Ala
 465                 470                 475                 480
 Arg Asn Asn Glu Asn Thr Gly Phe Asp Ala Leu Ser His Glu Cys Thr
                 485                 490                 495    
 Ala Lys Pro Leu Phe Pro Arg Val Glu Val Gln Ser Glu Gln Leu Thr
             500                 505                 510        
 Val Glu Glu Gln Ile Lys Arg Asn Arg Cys Tyr Ser Asp Thr Glu
         515                 520                 525        



      <210> 662
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 662
 Met His Thr Gln Pro Leu Lys Glu Ala Lys Arg Met Pro Asp Arg Pro
   1               5                  10                  15    
 Ile Lys Trp Asp Lys Ser Tyr Tyr Ser Phe Thr Gly Phe Lys Asp Pro
              20                  25                  30        
 Asp Glu Asp Leu Glu Gln Val Ser Arg Val Glu Thr Thr Leu Thr Ser
          35                  40                  45            
 Trp Leu Asp Asn Asn Gly Lys Ser Ala Val Lys Lys Leu Lys Asn Ser
      50                  55                  60                
 Leu Pro Leu Arg Lys Glu Leu Asp Arg Leu Lys Asp Glu Leu Ser His
  65                  70                  75                  80
 Gln Leu Gln Leu Ser Asp Ile Arg Trp Gln Arg Ser Trp Gly Ile Ala
                  85                  90                  95    
 His Arg Cys Ser Gln Leu His Ser Leu Ser Arg Leu Ala Gln Gln Asn
             100                 105                 110        
 Leu Glu Thr Leu Lys Lys Ala Lys Gly Cys Thr Ile Ile Phe Thr Asp
         115                 120                 125            
 Arg Ser Gly Met Ser Ala Val Gly His Val Met Leu Gly Thr Met Asp
     130                 135                 140                
 Val His His His Trp Thr Lys Leu Phe Glu Arg Leu Pro Ser Tyr Phe
 145                 150                 155                 160
 Asp Leu Gln Arg Arg Leu Met Ile Leu Glu Asp Gln Ile Ser Tyr Leu
                 165                 170                 175    
 Leu Gly Gly Ile Gln Val Val Tyr Ile Glu Glu Leu Gln Pro Val Leu
             180                 185                 190        
 Thr Leu Glu Glu Tyr Tyr Ser Leu Leu Asp Val Phe Tyr Asn Arg Leu
         195                 200                 205            
 Leu Lys Ser Arg Ile Leu Phe His Pro Arg Ser Leu Arg Gly Leu Gln
     210                 215                 220                
 Met Ile Leu Asn Ser Asp Arg Tyr Ala Pro Ser Leu His Glu Leu Gly
 225                 230                 235                 240
 His Phe Asn Ile Pro Thr Leu Cys Asp Pro Ala Asn Leu Gln Trp Phe
                 245                 250                 255    
 Ile Leu Thr Lys Ala Gln Gln Ala Arg Glu Asn Met Lys Arg Lys Glu
             260                 265                 270        
 Glu Leu Lys Val Ile Glu Asn Glu Leu Ile Gln Ala Ser Thr Lys Lys
         275                 280                 285            
 Phe Ser Leu Glu Lys Leu Tyr Lys Glu Pro Ser Ile Ser Ser Ile Gln
     290                 295                 300                
 Met Val Asp Cys Cys Lys Arg Leu Leu Glu Gln Ser Leu Pro Tyr Leu
 305                 310                 315                 320
 His Gly Met His Leu Cys Ile Ser His Phe Tyr Ser Val Met Gln Asp
                 325                 330                 335    
 Gly Asp Leu Cys Ile Pro Trp Asn Trp Lys Asn Gly Glu Ala Ile Lys
             340                 345                 350        





      <210> 663
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 663
 Met Asp Gly Leu Ile Glu Asp Ile Lys His Arg Arg Tyr Tyr Glu Lys
   1               5                  10                  15    
 Pro Cys Arg Arg Arg Gln Arg Glu Ser Tyr Glu Arg Cys Arg Arg Ile
              20                  25                  30        
 Tyr Asn Met Glu Met Ala Arg Lys Ile Asn Phe Leu Met Arg Lys Asn
          35                  40                  45            
 Arg Ala Asp Pro Trp Gln Gly Cys
      50                  55    



      <210> 664
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 664
 Met Thr Glu Ile Leu Leu Glu Arg Lys Tyr Arg Pro Ile Pro Glu Asp
   1               5                  10                  15    
 Val Leu Leu Arg Ala Phe Glu Val Leu Asp Ser Ala Lys Arg Gly Phe
              20                  25                  30        
 Leu Thr Lys Asp Glu Leu Ile Lys Tyr Met Thr Glu Glu Gly Glu Pro
          35                  40                  45            
 Phe Ser Gln Glu Glu Met Glu Glu Met Leu Ser Ala Ala Ile Asp Pro
      50                  55                  60                
 Glu Ser Asn Ser Ile Asn Tyr Lys Asp Tyr Ile Thr Met Met Val Ile
  65                  70                  75                  80
 Asp Glu Asn
            



      <210> 665
      <211> 688
      <212> PRT
      <213> Homo sapiens


      <400> 665
 Met Ala Thr Ala Ser Gly Ala Ser Asp Leu Ser Gly Ser Gly Ala Pro
   1               5                  10                  15    
 Pro Pro Gly Val Gly Ala Gln Ala Ala Val Ala Ala Glu Glu Glu Glu
              20                  25                  30        
 Arg Glu Val Val Arg Val Arg Val Lys Lys Cys Glu Ser Phe Leu Pro
          35                  40                  45            
 Pro Glu Phe Arg Ser Phe Ala Val Asp Pro Gln Ile Thr Ser Leu Asp
      50                  55                  60                
 Val Leu Gln His Ile Leu Ile Arg Ala Phe Asp Leu Ser Gly Lys Lys
  65                  70                  75                  80
 Asn Phe Gly Ile Ser Tyr Leu Gly Arg Asp Arg Leu Gly Gln Glu Val
                  85                  90                  95    
 Tyr Leu Ser Leu Leu Ser Asp Trp Asp Leu Ser Thr Ala Phe Ala Thr
             100                 105                 110        
 Ala Ser Lys Pro Tyr Leu Gln Leu Arg Val Asp Ile Arg Pro Ser Glu
         115                 120                 125            
 Asp Ser Pro Leu Leu Glu Asp Trp Asp Ile Ile Ser Pro Lys Asp Val
     130                 135                 140                
 Ile Gly Ser Asp Val Leu Leu Ala Glu Lys Arg Ser Ser Leu Thr Thr
 145                 150                 155                 160
 Ala Ala Leu Pro Phe Thr Gln Ser Ile Leu Thr Gln Val Gly Arg Thr
                 165                 170                 175    
 Leu Ser Lys Val Gln Gln Val Leu Ser Trp Ser Tyr Gly Glu Asp Val
             180                 185                 190        
 Lys Pro Phe Lys Pro Pro Leu Ser Asp Ala Glu Phe His Thr Tyr Leu
         195                 200                 205            
 Asn His Glu Gly Gln Leu Ser Arg Pro Glu Glu Leu Arg Leu Arg Ile
     210                 215                 220                
 Tyr His Gly Gly Val Glu Pro Ser Leu Arg Lys Val Val Trp Arg Tyr
 225                 230                 235                 240
 Leu Leu Asn Val Tyr Pro Asp Gly Leu Thr Gly Arg Glu Arg Met Asp
                 245                 250                 255    
 Tyr Met Lys Arg Lys Ser Arg Glu Tyr Glu Gln Leu Lys Ser Glu Trp
             260                 265                 270        
 Ala Gln Arg Ala Ser Pro Glu Asp Leu Glu Phe Ile Arg Ser Thr Val
         275                 280                 285            
 Leu Lys Asp Val Leu Arg Thr Asp Arg Ala His Pro Tyr Tyr Ala Gly
     290                 295                 300                
 Pro Glu Asp Gly Pro His Leu Arg Ala Leu His Asp Leu Leu Thr Thr
 305                 310                 315                 320
 Tyr Ala Val Thr His Pro Gln Val Ser Tyr Cys Gln Gly Met Ser Asp
                 325                 330                 335    
 Leu Ala Ser Pro Ile Leu Ala Val Met Asp His Glu Gly His Ala Phe
             340                 345                 350        
 Val Cys Phe Cys Gly Ile Met Lys Arg Leu Ala Ala Asn Phe His Pro
         355                 360                 365            
 Asp Gly Arg Ala Met Ala Thr Lys Phe Ala His Leu Lys Leu Leu Leu
     370                 375                 380                
 Arg His Ala Asp Pro Asp Phe Tyr Gln Tyr Leu Gln Glu Ala Gly Ala
 385                 390                 395                 400
 Asp Asp Leu Phe Phe Cys Tyr Arg Trp Leu Leu Leu Glu Leu Lys Arg
                 405                 410                 415    
 Glu Phe Ala Phe Asp Asp Ala Leu Arg Met Leu Glu Val Thr Trp Ser
             420                 425                 430        
 Ser Leu Pro Pro Asp Pro Pro Glu His Glu Val Glu Leu Val Gly Pro
         435                 440                 445            
 Pro Ser Gln Val Ala Asp Thr Gly Phe Gly Gly His Arg Gly Trp Pro
     450                 455                 460                
 Val Arg Gln Arg His Met Leu Arg Pro Ala Gly Gly Gly Gly Ser Thr
 465                 470                 475                 480
 Phe Glu Asp Ala Val Asp His Leu Ala Thr Ala Ser Gln Gly Pro Gly
                 485                 490                 495    
 Gly Gly Gly Arg Leu Leu Arg Gln Ala Ser Leu Asp Gly Leu Gln Gln
             500                 505                 510        
 Leu Arg Asp Asn Met Gly Ser Arg Arg Asp Pro Leu Val Gln Leu Pro
         515                 520                 525            
 His Pro Ala Ala Leu Ile Ser Ser Lys Ser Leu Ser Glu Pro Leu Leu
     530                 535                 540                
 Asn Ser Pro Asp Pro Leu Leu Ser Ser Phe Ser His Pro Asp Ser Pro
 545                 550                 555                 560
 Ser Ser Ser Ser Pro Pro Ser Thr Gln Glu Ala Ser Pro Thr Gly Asp
                 565                 570                 575    
 Met Ala Val Gly Ser Pro Leu Met Gln Glu Val Gly Ser Pro Lys Asp
             580                 585                 590        
 Pro Gly Lys Ser Leu Pro Pro Val Pro Pro Met Gly Leu Pro Pro Pro
         595                 600                 605            
 Gln Glu Phe Gly Arg Gly Asn Pro Phe Met Leu Phe Leu Cys Leu Ala
     610                 615                 620                
 Ile Leu Leu Glu His Arg Asp His Ile Met Arg Asn Gly Leu Asp Tyr
 625                 630                 635                 640
 Asn Glu Leu Ala Met His Phe Asp Arg Leu Val Arg Lys His His Leu
                 645                 650                 655    
 Gly Arg Val Leu Arg Arg Ala Arg Ala Leu Phe Ala Asp Tyr Leu Gln
             660                 665                 670        
 Ser Glu Val Trp Asp Ser Glu Glu Gly Ala Glu Ala Thr Ala Ala Ser
         675                 680                 685            





      <210> 666
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 666
 Met Arg Glu Lys Leu Ile Arg Leu Gln Ser Leu Tyr Ile Asp Gln Phe
   1               5                  10                  15    
 Lys Arg Leu Gln His Leu Leu Lys Glu Lys Lys Arg Arg Tyr Leu His
              20                  25                  30        
 Asn Arg Lys Val Glu His Glu Ala Leu Gly Ser Ser Leu Leu Thr Gly
          35                  40                  45            
 Pro Glu Gly Leu Leu Ala Lys Glu Arg Glu Asn Leu Lys Arg Leu Lys
      50                  55                  60                
 Cys Leu Arg Arg Tyr Arg Gln Arg Tyr Gly Val Glu Ala Leu Leu His
  65                  70                  75                  80
 Arg Gln Leu Lys Glu Arg Arg Met Leu Ala Thr Asp Gly Ala Ala Gln
                  85                  90                  95    
 Gln Ala His Thr Thr Arg Ser Ser Gln Arg Cys Leu Ala Phe Val Asp
             100                 105                 110        
 Asp Val Arg Cys Ser Asn Gln Ser Leu Pro Met Thr Arg His Cys Leu
         115                 120                 125            
 Thr His Ile Cys Gln Asp Thr Asn Gln Val Leu Phe Lys Cys Cys Gln
     130                 135                 140                
 Gly Ser Glu Glu Val Pro Cys Asn Lys Pro Val Pro Val Ser Leu Ser
 145                 150                 155                 160
 Glu Asp Pro Cys Cys Pro Leu His Phe Gln Leu Pro Pro Gln Met Tyr
                 165                 170                 175    
 Lys Pro Glu Gln Val Leu Ser Val Pro Asp Asp Leu Glu Ala Gly Pro
             180                 185                 190        
 Met Asp Leu Tyr Leu Ser Ala Ala Glu Leu Gln Pro Thr Glu Ser Leu
         195                 200                 205            
 Pro Leu Glu Phe Ser Asp Asp Leu Asp Val Val Gly Asp Gly Met Gln
     210                 215                 220                
 Cys Pro Pro Ser Pro Leu Leu Phe Asp Pro Ser Leu Thr Leu Glu Asp
 225                 230                 235                 240
 His Leu Val Lys Glu Ile Ala Glu Asp Pro Val Asp Ile Leu Gly Gln
                 245                 250                 255    
 Met Gln Met Ala Gly Asp Gly Cys Arg Ser Gln Gly Ser Arg Asn Ser
             260                 265                 270        
 Glu Lys Ala Ser Ala Pro Leu Ser Gln Ser Gly Leu Ala Thr Ala Asn
         275                 280                 285            
 Gly Lys Pro Glu Pro Thr Ser Ile Ser
     290                 295        



      <210> 667
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 667
 Met Thr Ala Val Gly Val Gln Ala Gln Arg Pro Leu Gly Gln Arg Gln
   1               5                  10                  15    
 Pro Arg Arg Ser Phe Phe Glu Ser Phe Ile Arg Thr Leu Ile Ile Thr
              20                  25                  30        
 Cys Val Ala Leu Ala Val Val Leu Ser Ser Val Ser Ile Cys Asp Gly
          35                  40                  45            
 His Trp Leu Leu Ala Glu Asp Arg Leu Phe Gly Leu Trp His Phe Cys
      50                  55                  60                
 Thr Thr Thr Asn Gln Ser Val Pro Ile Cys Phe Arg Asp Leu Gly Gln
  65                  70                  75                  80
 Ala His Val Pro Gly Leu Ala Val Gly Met Gly Leu Val Arg Ser Val
                  85                  90                  95    
 Gly Ala Leu Ala Val Val Ala Ala Ile Phe Gly Leu Glu Phe Leu Met
             100                 105                 110        
 Val Ser Gln Leu Cys Glu Asp Lys His Ser Gln Cys Lys Trp Val Met
         115                 120                 125            
 Gly Ser Ile Leu Leu Leu Val Ser Phe Val Leu Ser Ser Gly Gly Leu
     130                 135                 140                
 Leu Gly Phe Val Ile Leu Leu Arg Asn Gln Val Thr Leu Ile Gly Phe
 145                 150                 155                 160
 Thr Leu Met Phe Trp Cys Glu Phe Thr Ala Ser Phe Leu Leu Phe Leu
                 165                 170                 175    
 Asn Ala Ile Ser Gly Leu His Ile Asn Ser Ile Thr His Pro Trp Glu
             180                 185                 190        





      <210> 668
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 668
 Met Ser Tyr Leu Ser Gly Ser Ser Ala Ser Pro Ala Arg Arg Leu Gly
   1               5                  10                  15    
 Val Val Lys Val Val Pro Arg Pro Cys Leu Gln Trp Leu Glu Asn Pro
              20                  25                  30        
 Gly Gly Cys Leu Gly Pro Ser Gly Gln Arg Glu Ala Gly Ser Ser Ser
          35                  40                  45            
 Pro Gly Asp Cys Gly His Ile Gly Ala Cys Leu Gly Leu Glu Gly Gln
      50                  55                  60                
 Val Thr Ser Pro Ala Thr Leu Pro Ser Leu Leu Trp Gly Pro His Phe
  65                  70                  75                  80
 Arg Ala Thr Leu Pro Glu Ala His Ala Ser Ile His Ser Phe Ser Ala
                  85                  90                  95    
 Leu Asn Leu Ile His Lys Gln Pro Pro Pro Phe Pro Ser Pro Ser His
             100                 105                 110        
 Ser Val Asp Val Ile Leu Pro Pro Pro Val Ser Ile Leu Arg Gln Ala
         115                 120                 125            
 Ser Lys Glu Ala Leu Thr Leu Leu Pro Lys Trp Cys Phe Leu Lys Asn
     130                 135                 140                
 Thr Ile Thr Thr Leu Gly Ala Ile Phe Ser His Leu Pro Val Phe Arg
 145                 150                 155                 160
 Met
    



      <210> 669
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 669
 Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys
   1               5                  10                  15    
 Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu
              20                  25                  30        
 Lys Asp Asp Arg Leu Asp Thr Glu Lys Leu Cys Thr Phe Ser Gln Arg
          35                  40                  45            
 Phe Pro Leu Pro Ser Met Tyr Arg Ala Leu Val Trp Lys Val Leu Leu
      50                  55                  60                
 Gly Ile Leu Pro Pro His His Glu Ser His Ala Lys Val Met Met Tyr
  65                  70                  75                  80
 Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala Leu Lys Val Val Arg
                  85                  90                  95    
 Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val Tyr Leu Arg Met Tyr
             100                 105                 110        
 Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro Ser Phe Pro Leu Glu
         115                 120                 125            
 Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys Ala Met Glu Glu Met
     130                 135                 140                
 Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr Arg Arg Phe Val Asn
 145                 150                 155                 160
 Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro Gln Leu Pro Lys Ala
                 165                 170                 175    
 Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg Leu Leu Thr His Leu
             180                 185                 190        
 Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr Asp Leu Trp Phe Lys
         195                 200                 205            
 Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser Leu Gln Arg Val Trp
     210                 215                 220                
 Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu Val Phe Val Ala Val
 225                 230                 235                 240
 Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met Ala Leu Asn Ser Ala
                 245                 250                 255    
 Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro Gln Asp Ser Ser Asp
             260                 265                 270        
 Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His Lys His Cys Gly Thr
         275                 280                 285            
 Pro Val His Ser Ser
     290            



      <210> 670
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 670
 Met Thr Glu Asp Ser Gln Arg Asn Phe Arg Ser Val Tyr Tyr Glu Lys
   1               5                  10                  15    
 Val Gly Phe Arg Gly Val Glu Glu Lys Lys Ser Leu Glu Ile Leu Leu
              20                  25                  30        
 Lys Asp Asp Arg Leu Gly Ile Leu Pro Pro His His Glu Ser His Ala
          35                  40                  45            
 Lys Val Met Met Tyr Arg Lys Glu Gln Tyr Leu Asp Val Leu His Ala
      50                  55                  60                
 Leu Lys Val Val Arg Phe Val Ser Asp Ala Thr Pro Gln Ala Glu Val
  65                  70                  75                  80
 Tyr Leu Arg Met Tyr Gln Leu Glu Ser Gly Lys Leu Pro Arg Ser Pro
                  85                  90                  95    
 Ser Phe Pro Leu Glu Pro Asp Asp Glu Val Phe Leu Ala Ile Ala Lys
             100                 105                 110        
 Ala Met Glu Glu Met Val Glu Asp Ser Val Asp Cys Tyr Trp Ile Thr
         115                 120                 125            
 Arg Arg Phe Val Asn Gln Leu Asn Thr Lys Tyr Arg Asp Ser Leu Pro
     130                 135                 140                
 Gln Leu Pro Lys Ala Phe Glu Gln Tyr Leu Asn Leu Glu Asp Gly Arg
 145                 150                 155                 160
 Leu Leu Thr His Leu Arg Met Cys Ser Ala Ala Pro Lys Leu Pro Tyr
                 165                 170                 175    
 Asp Leu Trp Phe Lys Arg Cys Phe Ala Gly Cys Leu Pro Glu Ser Ser
             180                 185                 190        
 Leu Gln Arg Val Trp Asp Lys Val Val Ser Gly Ser Cys Lys Ile Leu
         195                 200                 205            
 Val Phe Val Ala Val Glu Ile Leu Leu Thr Phe Lys Ile Lys Val Met
     210                 215                 220                
 Ala Leu Asn Ser Ala Glu Lys Ile Thr Lys Phe Leu Glu Asn Ile Pro
 225                 230                 235                 240
 Gln Asp Ser Ser Asp Ala Ile Val Ser Lys Ala Ile Asp Leu Trp His
                 245                 250                 255    
 Lys His Cys Gly Thr Pro Val His Ser Ser
             260                 265    



      <210> 671
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 671
 Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro
   1               5                  10                  15    
 Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln
              20                  25                  30        
 Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu
          35                  40                  45            
 Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp
      50                  55                  60                
 Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr
  65                  70                  75                  80
 Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu
                  85                  90                  95    
 Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg
             100                 105                 110        
 His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu
         115                 120                 125            
 Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met
     130                 135                 140                
 Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr
 145                 150                 155                 160
 Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Val Gln
                 165                 170                 175    
 Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro
             180                 185                 190        
 Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro
         195                 200                 205            
 Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met
     210                 215                 220                
 Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu
 225                 230                 235                 240
 Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu
                 245                 250                 255    
 Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile
             260                 265                 270        
 Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys
         275                 280                 285            
 Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile
     290                 295                 300                
 Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile
 305                 310                 315                 320
 Pro Lys Pro Glu Leu His Lys Lys Glu Thr
                 325                 330



      <210> 672
      <211> 476
      <212> PRT
      <213> Homo sapiens


      <400> 672
 Met Ala Phe Gly Lys Ser His Arg Asp Pro Tyr Ala Thr Ser Val Gly
   1               5                  10                  15    
 His Leu Ile Glu Lys Ala Thr Phe Ala Gly Val Gln Thr Glu Asp Trp
              20                  25                  30        
 Gly Gln Phe Met His Ile Cys Asp Ile Ile Asn Thr Thr Gln Asp Gly
          35                  40                  45            
 Pro Lys Asp Ala Val Lys Ala Leu Lys Lys Arg Ile Ser Lys Asn Tyr
      50                  55                  60                
 Asn His Lys Glu Ile Gln Leu Thr Leu Ser Leu Ile Asp Met Cys Val
  65                  70                  75                  80
 Gln Asn Cys Gly Pro Ser Phe Gln Ser Leu Ile Val Lys Lys Glu Phe
                  85                  90                  95    
 Val Lys Glu Asn Leu Val Lys Leu Leu Asn Pro Arg Tyr Asn Leu Pro
             100                 105                 110        
 Leu Asp Ile Gln Asn Arg Ile Leu Asn Phe Ile Lys Thr Trp Ser Gln
         115                 120                 125            
 Gly Phe Pro Gly Gly Val Asp Val Ser Glu Val Lys Glu Val Tyr Leu
     130                 135                 140                
 Asp Leu Val Lys Lys Gly Val Gln Phe Pro Pro Ser Glu Ala Glu Ala
 145                 150                 155                 160
 Glu Thr Ala Arg Gln Glu Thr Ala Gln Ile Ser Ser Asn Pro Pro Thr
                 165                 170                 175    
 Ser Val Pro Thr Ala Pro Ala Leu Ser Ser Val Ile Ala Pro Lys Asn
             180                 185                 190        
 Ser Thr Val Thr Leu Val Pro Glu Gln Ile Gly Lys Leu His Ser Glu
         195                 200                 205            
 Leu Asp Met Val Lys Met Asn Val Arg Val Met Ser Ala Ile Leu Met
     210                 215                 220                
 Glu Asn Thr Pro Gly Ser Glu Asn His Glu Asp Ile Glu Leu Leu Gln
 225                 230                 235                 240
 Lys Leu Tyr Lys Thr Gly Arg Glu Met Gln Glu Arg Ile Met Asp Leu
                 245                 250                 255    
 Leu Val Val Val Glu Asn Glu Asp Val Thr Val Glu Leu Ile Gln Val
             260                 265                 270        
 Asn Glu Asp Leu Asn Asn Ala Ile Leu Gly Tyr Glu Arg Phe Thr Arg
         275                 280                 285            
 Asn Gln Gln Arg Ile Leu Glu Gln Asn Lys Asn Gln Lys Glu Ala Thr
     290                 295                 300                
 Asn Thr Thr Ser Glu Pro Ser Ala Pro Ser Gln Asp Leu Leu Asp Leu
 305                 310                 315                 320
 Ser Pro Ser Pro Arg Met Pro Arg Ala Thr Leu Gly Glu Leu Asn Thr
                 325                 330                 335    
 Met Asn Asn Gln Leu Ser Gly Leu Asn Phe Ser Leu Pro Ser Ser Asp
             340                 345                 350        
 Val Thr Asn Asn Leu Lys Pro Ser Leu His Pro Gln Met Asn Leu Leu
         355                 360                 365            
 Ala Leu Glu Asn Thr Glu Ile Pro Pro Phe Ala Gln Arg Thr Ser Gln
     370                 375                 380                
 Asn Leu Thr Ser Ser His Ala Tyr Asp Asn Phe Leu Glu His Ser Asn
 385                 390                 395                 400
 Ser Val Phe Leu Gln Pro Val Ser Leu Gln Thr Ile Ala Ala Ala Pro
                 405                 410                 415    
 Ser Asn Gln Ser Leu Pro Pro Leu Pro Ser Asn His Pro Ala Met Thr
             420                 425                 430        
 Lys Ser Asp Leu Gln Pro Pro Asn Tyr Tyr Glu Val Met Glu Phe Asp
         435                 440                 445            
 Pro Leu Ala Pro Ala Val Thr Thr Glu Ala Ile Tyr Glu Glu Ile Asp
     450                 455                 460                
 Ala His Gln His Lys Gly Ala Gln Asn Asp Gly Asp
 465                 470                 475    



      <210> 673
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 673
 Met Ala Phe Gly Lys Ser His Arg Asp Pro Tyr Ala Thr Ser Val Gly
   1               5                  10                  15    
 His Leu Ile Glu Lys Ala Thr Phe Ala Gly Val Gln Thr Glu Asp Trp
              20                  25                  30        
 Gly Gln Phe Met His Ile Cys Asp Ile Ile Asn Thr Thr Gln Asp Gly
          35                  40                  45            
 Pro Lys Asp Ala Val Lys Ala Leu Lys Lys Arg Ile Ser Lys Asn Tyr
      50                  55                  60                
 Asn His Lys Glu Ile Gln Leu Thr Leu Ser Lys Leu Tyr Lys Thr Gly
  65                  70                  75                  80
 Arg Glu Met Gln Glu Arg Ile Met Asp Leu Leu Val Val Val Glu Asn
                  85                  90                  95    
 Glu Asp Val Thr Val Glu Leu Ile Gln Val Asn Glu Asp Leu Asn Asn
             100                 105                 110        
 Ala Ile Leu Gly Tyr Glu Arg Phe Thr Arg Asn Gln Gln Arg Ile Leu
         115                 120                 125            
 Glu Gln Asn Lys Asn Gln Lys Glu Ala Thr Asn Thr Thr Ser Glu Pro
     130                 135                 140                
 Ser Ala Pro Ser Gln Asp Leu Leu Asp Leu Ser Pro Ser Pro Arg Met
 145                 150                 155                 160
 Pro Arg Ala Thr Leu Gly Glu Leu Asn Thr Met Asn Asn Gln Leu Ser
                 165                 170                 175    
 Gly Leu Asn Phe Ser Leu Pro Ser Ser Asp Val Thr Asn Asn Leu Lys
             180                 185                 190        
 Pro Ser Leu His Pro Gln Met Asn Leu Leu Ala Leu Glu Asn Thr Glu
         195                 200                 205            
 Ile Pro Pro Phe Ala Gln Arg Thr Ser Gln Asn Leu Thr Ser Ser His
     210                 215                 220                
 Ala Tyr Asp Asn Phe Leu Glu His Ser Asn Ser Val Phe Leu Gln Pro
 225                 230                 235                 240
 Val Ser Leu Gln Thr Ile Ala Ala Ala Pro Ser Asn Gln Ser Leu Pro
                 245                 250                 255    
 Pro Leu Pro Ser Asn His Pro Ala Met Thr Lys Ser Asp Leu Gln Pro
             260                 265                 270        
 Pro Asn Tyr Tyr Glu Val Met Glu Phe Asp Pro Leu Ala Pro Ala Val
         275                 280                 285            
 Thr Thr Glu Ala Ile Tyr Glu Glu Ile Asp Ala His Gln His Lys Gly
     290                 295                 300                
 Ala Gln Asn Asp Gly Asp
 305                 310



      <210> 674
      <211> 337
      <212> PRT
      <213> Homo sapiens


      <400> 674
 Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe
   1               5                  10                  15    
 Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp
              20                  25                  30        
 Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu
          35                  40                  45            
 Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val
      50                  55                  60                
 Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp
  65                  70                  75                  80
 Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile
                  85                  90                  95    
 Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly
             100                 105                 110        
 Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly
         115                 120                 125            
 Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile
     130                 135                 140                
 Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala
 145                 150                 155                 160
 Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg
                 165                 170                 175    
 Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala
             180                 185                 190        
 Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr
         195                 200                 205            
 Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile
     210                 215                 220                
 Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala
 225                 230                 235                 240
 Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln
                 245                 250                 255    
 Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr
             260                 265                 270        
 Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val
         275                 280                 285            
 Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser
     290                 295                 300                
 Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys
 305                 310                 315                 320
 Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp
                 325                 330                 335    
 Gln
    



      <210> 675
      <211> 482
      <212> PRT
      <213> Homo sapiens


      <400> 675
 Met Asp Glu Leu Val His Asp Leu Ala Ser Ala Leu Glu Gln Thr Ser
   1               5                  10                  15    
 Glu Gln Asn Lys Leu Gly Glu Leu Trp Glu Glu Met Ala Leu Ser Pro
              20                  25                  30        
 Arg Gln Gln Arg Arg Gln Leu Arg Lys Arg Arg Gly Arg Lys Arg Arg
          35                  40                  45            
 Ser Asp Phe Thr His Leu Ala Glu His Thr Cys Cys Tyr Ser Glu Ala
      50                  55                  60                
 Ser Glu Ser Ser Leu Asp Glu Ala Thr Lys Asp Cys Arg Glu Val Ala
  65                  70                  75                  80
 Pro Val Thr Asn Phe Ser Asp Ser Asp Asp Thr Met Val Ala Lys Arg
                  85                  90                  95    
 His Pro Ala Leu Asn Ala Ile Val Lys Ser Lys Gln His Ser Trp His
             100                 105                 110        
 Glu Ser Asp Ser Phe Thr Glu Asn Ala Pro Cys Arg Pro Leu Arg Arg
         115                 120                 125            
 Arg Arg Lys Val Lys Arg Val Thr Ser Glu Val Ala Ala Ser Leu Gln
     130                 135                 140                
 Gln Lys Leu Lys Val Ser Asp Trp Ser Tyr Glu Arg Gly Cys Arg Phe
 145                 150                 155                 160
 Lys Ser Ala Lys Lys Gln Arg Leu Ser Arg Trp Lys Glu Asn Thr Pro
                 165                 170                 175    
 Trp Thr Ser Ser Gly His Gly Leu Cys Glu Leu Ala Glu Asn Arg Thr
             180                 185                 190        
 Phe Leu Ser Lys Thr Gly Arg Lys Glu Arg Met Glu Cys Glu Thr Asp
         195                 200                 205            
 Glu Gln Lys Gln Gly Ser Asp Glu Asn Met Ser Glu Cys Glu Thr Ser
     210                 215                 220                
 Ser Val Cys Ser Ser Ser Asp Thr Gly Leu Phe Thr Asn Asp Glu Gly
 225                 230                 235                 240
 Arg Gln Gly Asp Asp Glu Gln Ser Asp Trp Phe Tyr Glu Gly Glu Cys
                 245                 250                 255    
 Val Pro Gly Phe Thr Val Pro Asn Leu Leu Pro Lys Trp Ala Pro Asp
             260                 265                 270        
 His Cys Ser Glu Val Glu Arg Met Asp Ser Gly Leu Asp Lys Phe Ser
         275                 280                 285            
 Asp Ser Thr Phe Leu Leu Pro Ser Arg Pro Ala Gln Arg Gly Tyr His
     290                 295                 300                
 Thr Arg Leu Asn Arg Leu Pro Gly Ala Ala Ala Arg Cys Leu Arg Lys
 305                 310                 315                 320
 Gly Arg Arg Arg Leu Val Gly Lys Glu Thr Ser Ile Asn Thr Leu Gly
                 325                 330                 335    
 Thr Glu Arg Ile Ser His Ile Ile Ser Asp Pro Arg Gln Lys Glu Lys
             340                 345                 350        
 Asn Lys Ala Leu Ala Ser Asp Phe Pro His Ile Ser Ala Cys Ala His
         355                 360                 365            
 Glu Phe Asn Pro Leu Ser Pro Leu Tyr Ser Leu Asp Val Leu Ala Asp
     370                 375                 380                
 Ala Ser His Arg Arg Cys Ser Pro Ala His Cys Ser Ala Arg Gln Ala
 385                 390                 395                 400
 Asn Val His Trp Gly Pro Pro Cys Ser Arg Asp Ile Lys Arg Lys Arg
                 405                 410                 415    
 Lys Pro Val Ala Thr Ala Ser Leu Ser Ser Pro Ser Ala Val His Met
             420                 425                 430        
 Asp Ala Val Glu Pro Thr Thr Pro Ala Ser Gln Ala Pro Lys Ser Pro
         435                 440                 445            
 Ser Ser Glu Trp Leu Val Arg Thr Ser Ala Ala Glu Lys Ala Thr Asp
     450                 455                 460                
 Ala Thr Thr Ala Thr Phe Phe Lys Met Pro Gln Glu Lys Ser Pro Gly
 465                 470                 475                 480
 Tyr Ser
        



      <210> 676
      <211> 383
      <212> PRT
      <213> Homo sapiens


      <400> 676
 Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg Gly Arg Gly
   1               5                  10                  15    
 Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala Glu Arg Ser
              20                  25                  30        
 Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro Ser Gly Ser
          35                  40                  45            
 Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala Ala Thr Val
      50                  55                  60                
 Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly Thr Glu Val
  65                  70                  75                  80
 Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr Lys Ser Ser
                  85                  90                  95    
 Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser Leu Leu Phe
             100                 105                 110        
 Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val Lys Val Val
         115                 120                 125            
 Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His Leu Leu Pro
     130                 135                 140                
 Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro Cys Leu Asp
 145                 150                 155                 160
 Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu Ile Pro Phe
                 165                 170                 175    
 His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile Asp Ala Ile
             180                 185                 190        
 Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser Ser Leu Ala
         195                 200                 205            
 His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr Met Lys Arg
     210                 215                 220                
 Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu Arg Lys Ser
 225                 230                 235                 240
 Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr Cys Ile Trp
                 245                 250                 255    
 Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg Leu Pro Ala
             260                 265                 270        
 Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln Arg Gln Ala
         275                 280                 285            
 Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala Ser Glu Ser
     290                 295                 300                
 Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala Ala Val Gln
 305                 310                 315                 320
 Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu Lys Pro Ser
                 325                 330                 335    
 Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys Leu Ser Ser
             340                 345                 350        
 Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser Pro Ser Lys
         355                 360                 365            
 Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro Met Leu
     370                 375                 380            



      <210> 677
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 677
 Met Lys Ser Gln Tyr Glu Val Phe Arg Ser Ser Arg Leu Ser Ser Asp
   1               5                  10                  15    
 Ala Thr Val Leu Thr Pro Asn Thr Glu Ser Ser Cys Asp Leu Met Thr
              20                  25                  30        
 Lys Thr Lys Ser Thr Ser Gly Asn Asp Asp Ser Thr Ser Leu Asp Leu
          35                  40                  45            
 Glu Trp Glu Asp Glu Glu Gly Met Asn Arg Met Leu Pro Met Arg Glu
      50                  55                  60                
 Arg Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala Ala Leu Lys Tyr Ser
  65                  70                  75                  80
 Asn Lys Lys Thr Gly Ser Asn Pro Thr Ser Ala Ser Asp Asp Ser Asn
                  85                  90                  95    
 Gly Leu Glu Trp Glu Asn Asp Phe Val Ser Ala Glu Met Asp Asp Asn
             100                 105                 110        
 Gly Asn Ser Glu Tyr Ser Gly Phe Val Asn Pro Val Leu Glu Leu Ser
         115                 120                 125            
 Asp Ser Gly Ile Arg His Ser Asp Thr Asp Gln Gln Thr Arg
     130                 135                 140        



      <210> 678
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 678
 Met Ser Glu Gln Asn Ile Cys Asn Gln Lys Asp Lys Ser Thr Leu Pro
   1               5                  10                  15    
 Phe Cys Gln Ala His Leu Cys Glu Glu Thr Thr Asn Arg Leu Cys Val
              20                  25                  30        
 Ser Asn Lys Ala Val Tyr Ser Leu Glu Cys Lys Trp Ala Glu Ser Glu
          35                  40                  45            
 Asn Arg Val Ser Glu Gly Arg Trp Gly Arg Gly Cys Phe Ile Gly Val
      50                  55                  60                
 Gly
  65



      <210> 679
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 679
 Met Ile Asn Phe Ile Phe Tyr Thr Asn Arg Leu Leu Arg Met Val Leu
   1               5                  10                  15    
 Lys Asn Tyr Lys Arg Asn Glu Leu Thr Val Gln Lys Phe Tyr Asn Tyr
              20                  25                  30        
 Tyr Thr Cys Val Leu Phe Gly Gly Trp Glu Met Tyr Phe Tyr Ile Val
          35                  40                  45            
 Ala Asn His Phe Ile Phe Val Asn Leu Asn Leu Met Gly Leu Phe Phe
      50                  55                  60                
 Phe Ile Ser Leu Asp Val Arg Phe Tyr Ser Leu Phe Lys
  65                  70                  75        



      <210> 680
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 680
 Met Gly Phe Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala
   1               5                  10                  15    
 Ser Val Glu Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg
              20                  25                  30        
 Ser Ser Arg Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser
          35                  40                  45            
 Gln Gln Pro Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn
      50                  55                  60                
 Pro Ser Gly Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser
  65                  70                  75                  80
 Asp Pro Pro Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu
                  85                  90                  95    
 Val Leu Gln Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala
             100                 105                 110        
 Leu Gln Glu Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg
         115                 120                 125            
 Lys Ser Gln Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Asp Ile
     130                 135                 140                
 Ile Thr Leu Arg Asn Phe Trp Lys Gln Asp Val Asp Gly Val Ala Ser
 145                 150                 155                 160
 Gly Pro Ile Val Leu His Cys Ala Ala Glu Leu
                 165                 170    



      <210> 681
      <211> 296
      <212> PRT
      <213> Homo sapiens


      <400> 681
 Met Ile Ala Glu Arg Leu Ala Arg Leu Arg Gln Glu Asn Lys Pro Lys
   1               5                  10                  15    
 Leu Val Pro Ser Gln Ala Glu Ile Glu Ala Arg Leu Ala Ala Leu Lys
              20                  25                  30        
 Asp Glu Arg Gln Gly Ser Ile Pro Ser Thr Gln Glu Met Glu Ala Arg
          35                  40                  45            
 Leu Ala Ala Leu Gln Gly Arg Val Leu Pro Ser Gln Thr Pro Gln Pro
      50                  55                  60                
 Ala His His Thr Pro Asp Thr Arg Thr Gln Ala Gln Gln Thr Gln Asp
  65                  70                  75                  80
 Leu Leu Thr Gln Leu Ala Ala Glu Val Ala Ile Asp Glu Ser Trp Lys
                  85                  90                  95    
 Gly Gly Gly Pro Ala Ala Ser Leu Gln Asn Asp Leu Asn Gln Gly Gly
             100                 105                 110        
 Pro Gly Ser Thr Asn Ser Lys Arg Gln Ala Asn Trp Ser Leu Glu Glu
         115                 120                 125            
 Glu Lys Ser Arg Leu Leu Ala Glu Ala Ala Leu Glu Leu Arg Glu Glu
     130                 135                 140                
 Asn Thr Arg Gln Glu Arg Ile Leu Ala Leu Ala Lys Arg Leu Ala Met
 145                 150                 155                 160
 Leu Arg Gly Gln Asp Pro Glu Arg Val Thr Leu Gln Asp Tyr Arg Leu
                 165                 170                 175    
 Pro Asp Ser Asp Asp Asp Gln Asp Glu Glu Thr Ala Ile Gln Arg Val
             180                 185                 190        
 Leu Gln Gln Leu Thr Glu Glu Ala Ala Leu Asp Glu Ala Ser Gly Phe
         195                 200                 205            
 Asn Ile Pro Ala Glu Gln Ala Ser Arg Pro Trp Thr Gln Pro Arg Gly
     210                 215                 220                
 Pro Glu Pro Glu Ala Gln Asp Val Asp Pro Arg Pro Glu Ala Glu Glu
 225                 230                 235                 240
 Glu Glu Leu Pro Trp Cys Cys Ile Cys Asn Glu Asp Ala Thr Leu Arg
                 245                 250                 255    
 Cys Ala Gly Cys Asp Gly Asp Leu Phe Cys Ala Arg Cys Phe Arg Glu
             260                 265                 270        
 Gly His Asp Ala Phe Glu Leu Lys Glu His Gln Thr Ser Ala Tyr Ser
         275                 280                 285            
 Pro Pro Arg Ala Gly Gln Glu His
     290                 295    



      <210> 682
      <211> 119
      <212> PRT
      <213> Homo sapiens


      <400> 682
 Met Asn Arg Val Asn Asp Pro Leu Ile Phe Ile Arg Asp Ile Lys Pro
   1               5                  10                  15    
 Gly Leu Lys Asn Leu Asn Val Val Phe Ile Val Leu Glu Ile Gly Arg
              20                  25                  30        
 Val Thr Lys Thr Lys Asp Gly His Glu Val Arg Ser Cys Lys Val Ala
          35                  40                  45            
 Asp Lys Thr Gly Ser Ile Thr Ile Ser Val Trp Asp Glu Ile Gly Gly
      50                  55                  60                
 Leu Ile Gln Pro Gly Asp Ile Ile Arg Leu Thr Arg Gly Tyr Ala Ser
  65                  70                  75                  80
 Met Trp Lys Gly Cys Leu Thr Leu Tyr Thr Gly Arg Gly Gly Glu Leu
                  85                  90                  95    
 Gln Lys Ile Gly Asp Leu Gly Ala Val Gln Ala Ala Ala Met Arg Asp
             100                 105                 110        
 Ser Ile His Tyr Tyr Pro Gly
         115                



      <210> 683
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 683
 Met Ile Ala Asp Arg Val Arg Thr Asp Ala Tyr Arg Leu Gly Ile Leu
   1               5                  10                  15    
 Arg Asn Trp Ala Ala Leu Arg Gly Lys Thr Val Leu Asp Val Gly Ala
              20                  25                  30        
 Gly Thr Gly Ile Leu Ser Ile Phe Cys Ala Gln Ala Gly Ala Arg Arg
          35                  40                  45            
 Val Tyr Ala Val Glu Ala Ser Ala Ile Trp Gln Gln Ala Arg Glu Val
      50                  55                  60                
 Val Arg Phe Asn Gly Leu Glu Asp Arg Val His Val Leu Pro Gly Pro
  65                  70                  75                  80
 Val Glu Thr Val Glu Leu Pro Glu Gln Val Asp Ala Ile Val Ser Glu
                  85                  90                  95    
 Trp Met Gly Tyr Gly Leu Leu His Glu Ser Met Leu Ser Ser Val Leu
             100                 105                 110        
 His Ala Arg Thr Lys Trp Leu Lys Glu Gly Gly Leu Leu Leu Pro Ala
         115                 120                 125            
 Ser Ala Glu Leu Phe Ile Ala Pro Ile Ser Asp Gln Met Leu Glu Trp
     130                 135                 140                
 Arg Leu Gly Phe Trp Ser Gln Val Lys Gln His Tyr Gly Val Asp Met
 145                 150                 155                 160
 Ser Cys Leu Glu Gly Phe Ala Thr Arg Cys Leu Met Gly His Ser Glu
                 165                 170                 175    
 Ile Val Val Gln Gly Leu Ser Gly Glu Asp Val Leu Ala Arg Pro Gln
             180                 185                 190        
 Arg Phe Ala Gln Leu Glu Leu Ser Arg Ala Gly Leu Glu Gln Glu Leu
         195                 200                 205            
 Glu Ala Gly Val Gly Gly Arg Phe Arg Cys Ser Cys Tyr Gly Ser Ala
     210                 215                 220                
 Pro Met His Gly Phe Ala Ile Trp Phe Gln Val Thr Phe Pro Gly Gly
 225                 230                 235                 240
 Glu Ser Glu Lys Pro Leu Val Leu Ser Thr Ser Pro Phe His Pro Ala
                 245                 250                 255    
 Thr His Trp Lys Gln Ala Leu Leu Tyr Leu Asn Glu Pro Val Gln Val
             260                 265                 270        
 Glu Gln Asp Thr Asp Val Ser Gly Glu Ile Thr Leu Leu Pro Ser Arg
         275                 280                 285            
 Asp Asn Pro Arg Arg Leu Arg Val Leu Leu Arg Tyr Lys Val Gly Asp
     290                 295                 300                
 Gln Glu Glu Lys Thr Lys Asp Phe Ala Met Glu Asp
 305                 310                 315    



      <210> 684
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 684
 Met Ala Ala Val Lys Ala Ser Thr Ser Lys Ala Thr Arg Pro Trp Tyr
   1               5                  10                  15    
 Ser His Pro Val Tyr Ala Arg Tyr Trp Gln His Tyr His Gln Ala Met
              20                  25                  30        
 Ala Trp Met Gln Ser His His Asn Ala Tyr Arg Lys Ala Val Glu Ser
          35                  40                  45            
 Cys Phe Asn Leu Pro Trp Tyr Leu Pro Ser Ala Leu Leu Pro Gln Ser
      50                  55                  60                
 Ser Tyr Asp Asn Glu Ala Ala Tyr Pro Gln Ser Phe Tyr Asp His His
  65                  70                  75                  80
 Val Ala Trp Gln Asp Tyr Pro Cys Ser Ser Ser His Phe Arg Arg Ser
                  85                  90                  95    
 Gly Gln His Pro Arg Tyr Ser Ser Arg Ile Gln Ala Ser Thr Lys Glu
             100                 105                 110        
 Asp Gln Ala Leu Ser Lys Glu Glu Glu Met Glu Thr Glu Ser Asp Ala
         115                 120                 125            
 Glu Val Glu Cys Asp Leu Ser Asn Met Glu Ile Thr Glu Glu Leu Arg
     130                 135                 140                
 Gln Tyr Phe Ala Glu Thr Glu Arg His Arg Glu Glu Arg Arg Arg Gln
 145                 150                 155                 160
 Gln Gln Leu Asp Ala Glu Arg Leu Asp Ser Tyr Val Asn Ala Asp His
                 165                 170                 175    
 Asp Leu Tyr Cys Asn Thr Arg Arg Ser Val Glu Ala Pro Thr Glu Arg
             180                 185                 190        
 Pro Gly Glu Arg Arg Gln Ala Glu Met Lys Arg Leu Tyr Gly Asp Ser
         195                 200                 205            
 Ala Ala Lys Ile Gln Ala Met Glu Ala Ala Val Gln Leu Ser Phe Asp
     210                 215                 220                
 Lys His Cys Asp Arg Lys Gln Pro Lys Tyr Trp Pro Val Ile Pro Leu
 225                 230                 235                 240
 Lys Phe
        



      <210> 685
      <211> 298
      <212> PRT
      <213> Homo sapiens


      <400> 685
 Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr
   1               5                  10                  15    
 Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu
              20                  25                  30        
 His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr
          35                  40                  45            
 Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser
      50                  55                  60                
 Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe
  65                  70                  75                  80
 Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser
                  85                  90                  95    
 Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His
             100                 105                 110        
 Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln
         115                 120                 125            
 Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys
     130                 135                 140                
 Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala
 145                 150                 155                 160
 Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys
                 165                 170                 175    
 Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp
             180                 185                 190        
 His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg
         195                 200                 205            
 Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg
     210                 215                 220                
 Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu
 225                 230                 235                 240
 Ser Thr Thr Glu Thr Asn Trp Pro Arg Glu Leu Lys Glu Gly Leu Gly
                 245                 250                 255    
 Trp Leu Gly Lys Glu Ala Ile Gly Ile Ala Ala Pro Cys Leu Gly Ala
             260                 265                 270        
 Asp Val Ser Pro Thr Asn Thr Ser Gly Glu Ala Gln Arg Pro Gly Leu
         275                 280                 285            
 Gly Asp Asp Ser Leu Gly Arg Gln Glu Arg
     290                 295            



      <210> 686
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp
   1               5                  10                  15    
 Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn
              20                  25                  30        
 Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe
          35                  40                  45            
 Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys
      50                  55                  60                
 Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala
  65                  70                  75                  80
 Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu
                  85                  90                  95    
 Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala
             100                 105                 110        
 Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val
         115                 120                 125            
 Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu
     130                 135                 140                
 Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val
 145                 150                 155                 160
 Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile
                 165                 170                 175    
 Gly Lys Ala Arg Leu Asn Asn Ile Ser Ile Ile Gly Pro Leu Asp Met
             180                 185                 190        
 Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser
         195                 200                 205            
 Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile
     210                 215                 220                
 Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser
 225                 230                 235                 240
 Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn
                 245                 250                 255    
 Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro
             260                 265                 270        
 Gln Gln
        



      <210> 687
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 687
 Met Glu Arg Glu Gly Ser Gly Gly Ser Gly Gly Ser Ala Gly Leu Leu
   1               5                  10                  15    
 Gln Gln Ile Leu Ser Leu Lys Val Val Pro Arg Val Gly Asn Gly Thr
              20                  25                  30        
 Leu Cys Pro Asn Ser Thr Ser Leu Cys Ser Phe Pro Glu Met Trp Tyr
          35                  40                  45            
 Gly Val Phe Leu Trp Ala Leu Val Ser Ser Leu Phe Phe His Val Pro
      50                  55                  60                
 Ala Gly Leu Leu Ala Leu Phe Thr Leu Arg His His Lys Tyr Gly Arg
  65                  70                  75                  80
 Phe Met Ser Val Ser Ile Leu Leu Met Gly Ile Val Gly Pro Ile Thr
                  85                  90                  95    
 Ala Gly Ile Leu Thr Ser Ala Ala Ile Ala Gly Val Tyr Arg Ala Ala
             100                 105                 110        
 Gly Lys Glu Met Ile Pro Phe Glu Ala Leu Thr Leu Gly Thr Gly Gln
         115                 120                 125            
 Thr Phe Cys Val Leu Val Val Ser Phe Leu Arg Ile Leu Ala Thr Leu
     130                 135                 140                





      <210> 688
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 688
 Met Ser Glu Phe Trp Leu Cys Phe Asn Cys Cys Ile Ala Glu Gln Pro
   1               5                  10                  15    
 Gln Pro Lys Arg Arg Arg Arg Ile Asp Arg Ser Met Ile Gly Glu Pro
              20                  25                  30        
 Thr Asn Phe Val His Thr Ala His Val Gly Ser Gly Asp Leu Phe Ser
          35                  40                  45            
 Gly Met Asn Ser Val Ser Ser Ile Gln Asn Gln Met Gln Ser Lys Gly
      50                  55                  60                
 Gly Tyr Gly Gly Gly Met Pro Ala Asn Val Gln Met Gln Leu Val Asp
  65                  70                  75                  80
 Thr Lys Ala Gly
                



      <210> 689
      <211> 479
      <212> PRT
      <213> Homo sapiens


      <400> 689
 Met Asn Gly Met Leu Leu Asn Gly Arg Lys Val Phe Val Gly Gln Phe
   1               5                  10                  15    
 Lys Ser Arg Lys Glu Arg Glu Ala Glu Leu Gly Ala Arg Ala Lys Glu
              20                  25                  30        
 Phe Pro Asn Val Tyr Ile Lys Asn Phe Gly Glu Asp Met Asp Asp Glu
          35                  40                  45            
 Arg Leu Lys Asp Leu Phe Gly Lys Phe Gly Pro Ala Leu Ser Val Lys
      50                  55                  60                
 Val Met Thr Asp Glu Ser Gly Lys Ser Lys Gly Phe Gly Phe Val Ser
  65                  70                  75                  80
 Phe Glu Arg His Glu Asp Ala Gln Lys Ala Val Asp Glu Met Asn Gly
                  85                  90                  95    
 Lys Glu Leu Asn Gly Lys Gln Ile Tyr Val Gly Arg Ala Gln Lys Lys
             100                 105                 110        
 Val Glu Arg Gln Thr Glu Leu Lys Arg Lys Phe Glu Gln Met Lys Gln
         115                 120                 125            
 Asp Arg Ile Thr Arg Tyr Gln Gly Val Asn Leu Tyr Val Lys Asn Leu
     130                 135                 140                
 Asp Asp Gly Ile Asp Asp Glu Arg Leu Arg Lys Glu Phe Ser Pro Phe
 145                 150                 155                 160
 Gly Thr Ile Thr Ser Ala Lys Val Met Met Glu Gly Gly Arg Ser Lys
                 165                 170                 175    
 Gly Phe Gly Phe Val Cys Phe Ser Ser Pro Glu Glu Ala Thr Lys Ala
             180                 185                 190        
 Val Thr Glu Met Asn Gly Arg Ile Val Ala Thr Lys Pro Leu Tyr Val
         195                 200                 205            
 Ala Leu Ala Gln Arg Lys Glu Glu Arg Gln Ala His Leu Thr Asn Gln
     210                 215                 220                
 Tyr Met Gln Arg Met Ala Ser Val Arg Ala Val Pro Asn Pro Val Ile
 225                 230                 235                 240
 Asn Pro Tyr Gln Pro Ala Pro Pro Ser Gly Tyr Phe Met Ala Ala Ile
                 245                 250                 255    
 Pro Gln Thr Gln Asn Arg Ala Ala Tyr Tyr Pro Pro Ser Gln Ile Ala
             260                 265                 270        
 Gln Leu Arg Pro Ser Pro Arg Trp Thr Ala Gln Gly Ala Arg Pro His
         275                 280                 285            
 Pro Phe Gln Asn Met Pro Gly Ala Ile Arg Pro Ala Ala Pro Arg Pro
     290                 295                 300                
 Pro Phe Ser Thr Met Arg Pro Ala Ser Ser Gln Val Pro Arg Val Met
 305                 310                 315                 320
 Ser Thr Gln Arg Val Ala Asn Thr Ser Thr Gln Thr Met Gly Pro Arg
                 325                 330                 335    
 Pro Ala Ala Ala Ala Ala Ala Ala Thr Pro Ala Val Arg Thr Val Pro
             340                 345                 350        
 Gln Tyr Lys Tyr Ala Ala Gly Val Arg Asn Pro Gln Gln His Leu Asn
         355                 360                 365            
 Ala Gln Pro Gln Val Thr Met Gln Gln Pro Ala Val His Val Gln Gly
     370                 375                 380                
 Gln Glu Pro Leu Thr Ala Ser Met Leu Ala Ser Ala Pro Pro Gln Glu
 385                 390                 395                 400
 Gln Lys Gln Met Leu Gly Glu Arg Leu Phe Pro Leu Ile Gln Ala Met
                 405                 410                 415    
 His Pro Thr Leu Ala Gly Lys Ile Thr Gly Met Leu Leu Glu Ile Asp
             420                 425                 430        
 Asn Ser Glu Leu Leu His Met Leu Glu Ser Pro Glu Ser Leu Arg Ser
         435                 440                 445            
 Lys Val Asp Glu Ala Val Ala Val Leu Gln Ala His Gln Ala Lys Glu
     450                 455                 460                
 Ala Ala Gln Lys Ala Val Asn Ser Ala Thr Gly Val Pro Thr Val
 465                 470                 475                



      <210> 690
      <211> 532
      <212> PRT
      <213> Homo sapiens


      <400> 690
 Met Asp Gln Phe Gly Asp Ile Leu Glu Gly Glu Val Asp His Ser Phe
   1               5                  10                  15    
 Phe Asp Ser Asp Phe Glu Glu Gly Lys Lys Cys Glu Thr Asn Ser Val
              20                  25                  30        
 Phe Asp Lys Gln Asn Asp Asp Pro Lys Glu Arg Ile Asp Lys Asp Thr
          35                  40                  45            
 Lys Asn Val Asn Ser Asn Thr Gly Met Gln Thr Thr Glu Asn Tyr Leu
      50                  55                  60                
 Thr Glu Lys Gly Asn Glu Arg Asn Val Lys Phe Pro Pro Glu His Pro
  65                  70                  75                  80
 Val Glu Asn Asp Val Thr Gln Thr Val Ser Ser Phe Ser Leu Pro Ala
                  85                  90                  95    
 Ser Ser Arg Ser Lys Lys Leu Cys Asp Val Thr Thr Gly Leu Lys Ile
             100                 105                 110        
 His Val Ser Ile Pro Asn Arg Ile Pro Lys Ile Val Lys Glu Gly Glu
         115                 120                 125            
 Asp Asp Tyr Tyr Thr Asp Gly Glu Glu Ser Ser Asp Asp Gly Lys Lys
     130                 135                 140                
 Tyr His Val Lys Ser Lys Ser Ala Lys Pro Ser Thr Asn Val Lys Lys
 145                 150                 155                 160
 Ser Ile Arg Lys Lys Tyr Cys Lys Val Ser Ser Ser Ser Ser Ser Ser
                 165                 170                 175    
 Leu Ser Ser Ser Ser Ser Gly Ser Gly Thr Asp Cys Leu Asp Ala Gly
             180                 185                 190        
 Ser Asp Ser His Leu Ser Asp Ser Ser Pro Ser Ser Lys Ser Ser Lys
         195                 200                 205            
 Lys His Val Ser Gly Ile Thr Leu Leu Ser Pro Lys His Lys Tyr Lys
     210                 215                 220                
 Ser Gly Ile Lys Ser Thr Glu Thr Gln Pro Ser Ser Thr Thr Pro Lys
 225                 230                 235                 240
 Cys Gly His Tyr Pro Glu Glu Ser Glu Asp Thr Val Thr Asp Val Ser
                 245                 250                 255    
 Pro Leu Ser Thr Pro Asp Ile Ser Pro Leu Gln Ser Phe Glu Leu Gly
             260                 265                 270        
 Ile Ala Asn Asp Gln Lys Val Lys Ile Lys Lys Gln Glu Asn Val Ser
         275                 280                 285            
 Gln Glu Ile Tyr Glu Asp Val Glu Asp Leu Lys Asn Asn Ser Lys Tyr
     290                 295                 300                
 Leu Lys Ala Ala Lys Lys Gly Lys Glu Lys His Glu Pro Asp Val Ser
 305                 310                 315                 320
 Ser Lys Ser Ser Ser Val Leu Asp Ser Ser Leu Asp His Arg His Lys
                 325                 330                 335    
 Gln Lys Val Leu His Asp Thr Met Asp Leu Asn His Leu Leu Lys Ala
             340                 345                 350        
 Phe Leu Gln Leu Asp Lys Lys Gly Pro Gln Lys His His Phe Asp Gln
         355                 360                 365            
 Pro Ser Val Ala Pro Gly Lys Asn Tyr Ser Phe Thr Arg Glu Glu Val
     370                 375                 380                
 Arg Gln Ile Asp Arg Glu Asn Gln Arg Leu Leu Lys Glu Leu Ser Arg
 385                 390                 395                 400
 Gln Ala Glu Lys Pro Gly Ser Lys Ser Thr Ile Pro Arg Ser Ala Asp
                 405                 410                 415    
 His Pro Pro Lys Leu Tyr His Ser Ala Leu Asn Arg Gln Lys Glu Gln
             420                 425                 430        
 Gln Arg Ile Glu Arg Glu Asn Leu Ala Leu Leu Lys Arg Leu Glu Ala
         435                 440                 445            
 Val Lys Pro Thr Val Gly Met Lys Arg Ser Glu Gln Leu Met Asp Tyr
     450                 455                 460                
 His Arg Asn Met Gly Tyr Leu Asn Ser Ser Pro Leu Ser Arg Arg Ala
 465                 470                 475                 480
 Arg Ser Thr Leu Gly Gln Tyr Ser Pro Leu Arg Ala Ser Arg Thr Ser
                 485                 490                 495    
 Ser Ala Thr Ser Gly Leu Ser Cys Arg Ser Glu Arg Ser Ala Val Asp
             500                 505                 510        
 Pro Ser Ser Gly His Pro Arg Arg Arg Pro Lys Pro Pro Asn Val Arg
         515                 520                 525            
 Thr Ala Trp Leu
     530        



      <210> 691
      <211> 344
      <212> PRT
      <213> Homo sapiens


      <400> 691
 Met Ala Ala Ala Thr Glu His Asn Arg Pro Ser Ser Gly Asp Arg Asn
   1               5                  10                  15    
 Leu Glu Arg Arg Cys Ser Pro Asn Leu Ser Arg Glu Val Leu Tyr Glu
              20                  25                  30        
 Ile Phe Arg Ser Leu His Thr Leu Val Gly Gln Leu Asp Leu Arg Asp
          35                  40                  45            
 Asp Val Val Lys Ile Thr Ile Asp Trp Asn Lys Leu Gln Ser Leu Ser
      50                  55                  60                
 Ala Phe Gln Pro Ala Leu Leu Phe Ser Ala Leu Glu Gln His Ile Leu
  65                  70                  75                  80
 Tyr Leu Gln Pro Phe Leu Ala Lys Leu Gln Ser Pro Ile Lys Glu Glu
                  85                  90                  95    
 Asn Thr Thr Ala Val Glu Glu Ile Gly Arg Thr Glu Met Gly Asn Lys
             100                 105                 110        
 Asn Glu Val Asn Asp Lys Phe Ser Ile Gly Asp Leu Gln Glu Glu Glu
         115                 120                 125            
 Lys His Lys Glu Ser Asp Leu Arg Asp Val Lys Lys Thr Gln Ile His
     130                 135                 140                
 Phe Asp Pro Glu Val Val Gln Ile Lys Ala Gly Lys Ala Glu Ile Asp
 145                 150                 155                 160
 Arg Arg Ile Ser Ala Phe Ile Glu Arg Lys Gln Ala Glu Ile Asn Glu
                 165                 170                 175    
 Asn Asn Val Arg Glu Phe Cys Asn Val Ile Asp Cys Asn Gln Glu Asn
             180                 185                 190        
 Ser Cys Ala Arg Thr Asp Ala Ile Phe Thr Pro Tyr Pro Gly Phe Lys
         195                 200                 205            
 Ser His Val Lys Val Ser Arg Val Val Asn Thr Tyr Gly Pro Gln Thr
     210                 215                 220                
 Arg Pro Glu Gly Ile Pro Gly Ser Gly His Lys Pro Asn Ser Met Leu
 225                 230                 235                 240
 Arg Asp Cys Gly Asn Gln Ala Val Glu Glu Arg Leu Gln Asn Ile Glu
                 245                 250                 255    
 Ala His Leu Arg Leu Gln Thr Gly Gly Pro Val Pro Arg Asp Ile Tyr
             260                 265                 270        
 Gln Arg Ile Lys Lys Leu Glu Asp Lys Ile Leu Glu Leu Glu Gly Ile
         275                 280                 285            
 Ser Pro Glu Tyr Phe Gln Ser Val Ser Phe Ser Gly Lys Arg Arg Lys
     290                 295                 300                
 Val Gln Pro Pro Gln Gln Asn Tyr Ser Leu Ala Glu Leu Asp Glu Lys
 305                 310                 315                 320
 Ile Ser Ala Leu Lys Gln Ala Leu Leu Arg Lys Ser Arg Glu Ala Glu
                 325                 330                 335    
 Ser Met Ala Thr His His Leu Pro
             340                



      <210> 692
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 692
 Met Ala Ser Ala Leu Arg Pro Pro Arg Val Pro Lys Pro Lys Gly Val
   1               5                  10                  15    
 Leu Pro Ser His Tyr Tyr Glu Ser Phe Leu Glu Lys Lys Gly Pro Cys
              20                  25                  30        
 Asp Arg Asp Tyr Lys Lys Phe Trp Ala Gly Leu Gln Gly Leu Thr Ile
          35                  40                  45            
 Tyr Phe Tyr Asn Ser Asn Arg Asp Phe Gln His Val Glu Lys Leu Asn
      50                  55                  60                
 Leu Gly Ala Phe Glu Lys Leu Thr Asp Glu Ile Pro Trp Gly Ser Ser
  65                  70                  75                  80
 Arg Asp Pro Gly Thr His Phe Ser Leu Ile Leu Arg Asn Gln Glu Ile
                  85                  90                  95    
 Lys Phe Lys Val Glu Thr Leu Glu Cys Arg Glu Met Trp Lys Gly Phe
             100                 105                 110        
 Ile Leu Thr Val Val Glu Leu Arg Val Pro Thr Asp Leu Thr Leu Leu
         115                 120                 125            
 Pro Gly His Leu Tyr Met Met Ser Glu Val Leu Ala Lys Glu Glu Ala
     130                 135                 140                
 Arg Arg Ala Leu Glu Thr Pro Ser Cys Phe Leu Lys Val Ser Arg Leu
 145                 150                 155                 160
 Glu Ala Gln Leu Leu Leu Glu Arg Tyr Pro Glu Cys Gly Asn Leu Leu
                 165                 170                 175    
 Leu Arg Pro Ser Gly Asp Gly Ala Asp Gly Val Ser Val Thr Thr Arg
             180                 185                 190        
 Gln Met His Asn Gly Thr His Val Val Arg His Tyr Lys Val Lys Arg
         195                 200                 205            
 Glu Gly Pro Lys Tyr Val Ile Asp Val Glu Gln Pro Phe Ser Cys Thr
     210                 215                 220                
 Ser Leu Asp Ala Val Val Asn Tyr Phe Val Ser His Thr Lys Lys Ala
 225                 230                 235                 240
 Leu Val Pro Phe Leu Leu Asp Glu Asp Tyr Glu Lys Val Leu Gly Tyr
                 245                 250                 255    
 Val Glu Ala Asp Lys Glu Asn Gly Glu Asn Val Trp Val Ala Pro Ser
             260                 265                 270        
 Ala Pro Gly Pro Gly Pro Ala Pro Cys Thr Gly Gly Pro Lys Pro Leu
         275                 280                 285            
 Ser Pro Ala Ser Ser Gln Asp Lys Leu Pro Pro Leu Pro Pro Leu Pro
     290                 295                 300                
 Asn Gln Glu Glu Asn Tyr Val Thr Pro Ile Gly Asp Gly Pro Ala Val
 305                 310                 315                 320
 Asp Tyr Glu Asn Gln Asp Val Ala Ser Ser Ser Trp Pro Val Ile Leu
                 325                 330                 335    
 Lys Pro Lys Lys Leu Pro Lys Pro Pro Ala Lys Leu Pro Lys Pro Pro
             340                 345                 350        
 Val Gly Pro Lys Pro Val Glu Lys Gly Phe His His Val Ala Gln Ala
         355                 360                 365            
 Gly Leu Glu Leu Leu Thr Ser Ser Asp Pro Pro Thr Ser Ala Ser Gln
     370                 375                 380                
 Ser Ala Gly Ile Thr Gly Val Ser His His Thr Trp Pro His Leu Ser
 385                 390                 395                 400
 Ser Leu Pro Glu Pro Lys Val Phe Asn Gly Gly Leu Gly Arg Lys Leu
                 405                 410                 415    
 Pro Val Ser Ser Ala Gln Pro Leu Phe Pro Thr Ala Gly Leu Ala Asp
             420                 425                 430        
 Met Thr Ala Glu Leu Gln Lys Lys Leu Glu Lys Arg Arg Ala Leu Glu
         435                 440                 445            
 His
    



      <210> 693
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 693
 Met Ala Ser Ala Leu Arg Pro Pro Arg Val Pro Lys Pro Lys Gly Val
   1               5                  10                  15    
 Leu Pro Ser His Tyr Tyr Glu Ser Phe Leu Glu Lys Lys Gly Pro Cys
              20                  25                  30        
 Asp Arg Asp Tyr Lys Lys Phe Trp Ala Gly Leu Gln Gly Leu Thr Ile
          35                  40                  45            
 Tyr Phe Tyr Asn Ser Asn Arg Asp Phe Gln His Val Glu Lys Leu Asn
      50                  55                  60                
 Leu Gly Ala Phe Glu Lys Leu Thr Asp Glu Ile Pro Trp Gly Ser Ser
  65                  70                  75                  80
 Arg Asp Pro Gly Thr His Phe Ser Leu Ile Leu Arg Asn Gln Glu Ile
                  85                  90                  95    
 Lys Phe Lys Val Glu Thr Leu Glu Cys Arg Glu Met Trp Lys Gly Phe
             100                 105                 110        
 Ile Leu Thr Val Val Glu Leu Arg Val Pro Thr Asp Leu Thr Leu Leu
         115                 120                 125            
 Pro Gly His Leu Tyr Met Met Ser Glu Val Leu Ala Lys Glu Glu Ala
     130                 135                 140                
 Arg Arg Ala Leu Glu Thr Pro Ser Cys Phe Leu Lys Val Ser Arg Leu
 145                 150                 155                 160
 Glu Ala Gln Leu Leu Leu Glu Arg Tyr Pro Glu Cys Gly Asn Leu Leu
                 165                 170                 175    
 Leu Arg Pro Ser Gly Asp Gly Ala Asp Gly Val Ser Val Thr Thr Arg
             180                 185                 190        
 Gln Met His Asn Gly Thr His Val Val Arg His Tyr Lys Val Lys Arg
         195                 200                 205            
 Glu Gly Pro Lys Tyr Val Ile Asp Val Glu Gln Pro Phe Ser Cys Thr
     210                 215                 220                
 Ser Leu Asp Ala Val Val Asn Tyr Phe Val Ser His Thr Lys Lys Ala
 225                 230                 235                 240
 Leu Val Pro Phe Leu Leu Asp Glu Asp Tyr Glu Lys Val Leu Gly Tyr
                 245                 250                 255    
 Val Glu Ala Asp Lys Glu Asn Gly Glu Asn Val Trp Val Ala Pro Ser
             260                 265                 270        
 Ala Pro Gly Pro Gly Pro Ala Pro Cys Thr Gly Gly Pro Lys Pro Leu
         275                 280                 285            
 Ser Pro Ala Ser Ser Gln Asp Lys Leu Pro Pro Leu Pro Pro Leu Pro
     290                 295                 300                
 Asn Gln Glu Glu Asn Tyr Val Thr Pro Ile Gly Asp Gly Pro Ala Val
 305                 310                 315                 320
 Asp Tyr Glu Asn Gln Asp Val Ala Ser Ser Ser Trp Pro Val Ile Leu
                 325                 330                 335    
 Lys Pro Lys Lys Leu Pro Lys Pro Pro Ala Lys Leu Pro Lys Pro Pro
             340                 345                 350        
 Val Gly Pro Lys Pro Glu Pro Lys Val Phe Asn Gly Gly Leu Gly Arg
         355                 360                 365            
 Lys Leu Pro Val Ser Ser Ala Gln Pro Leu Phe Pro Thr Ala Gly Leu
     370                 375                 380                
 Ala Asp Met Thr Ala Glu Leu Gln Lys Lys Leu Glu Lys Arg Arg Ala
 385                 390                 395                 400
 Leu Glu His
            



      <210> 694
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 694
 Met Pro Gly Asn Leu Gly Cys Tyr Lys Asp His Gly Asn Pro Pro Pro
   1               5                  10                  15    
 Leu Thr Gly Thr Ser Lys Thr Ser Asn Lys Leu Thr Ile Gln Thr Cys
              20                  25                  30        
 Ile Ser Phe Cys Arg Ser Gln Arg Phe Lys Phe Ala Gly Met Glu Ser
          35                  40                  45            
 Gly Tyr Ala Cys Phe Cys Gly Asn Asn Pro Asp Tyr Trp Lys Tyr Gly
      50                  55                  60                
 Glu Ala Ala Ser Thr Glu Cys Asn Ser Val Cys Phe Gly Asp His Thr
  65                  70                  75                  80
 Gln Pro Cys Gly Gly Asp Gly Arg Ile Ile Leu Phe Asp Thr Leu Val
                  85                  90                  95    
 Gly Ala Cys Gly Gly Asn Tyr Ser Ala Met Ser Ser Val Val Tyr Ser
             100                 105                 110        
 Pro Asp Phe Pro Asp Thr Tyr Ala Thr Gly Arg Val Cys Tyr Trp Thr
         115                 120                 125            
 Ile Arg Val Pro Gly Ala Ser His Ile His Phe Ser Phe Pro Leu Phe
     130                 135                 140                
 Asp Ile Arg Asp Ser Ala Asp Met Val Glu Leu Leu Asp Gly Tyr Thr
 145                 150                 155                 160
 His Arg Val Leu Ala Arg Phe His Gly Arg Ser Arg Pro Pro Leu Ser
                 165                 170                 175    
 Phe Asn Val Ser Leu Asp Phe Val Ile Leu Tyr Phe Phe Ser Asp Arg
             180                 185                 190        
 Ile Asn Gln Ala Gln Gly Phe Ala Val Leu Tyr Gln Ala Val Lys Glu
         195                 200                 205            
 Glu Leu Pro Gln Glu Arg Pro Ala Val Asn Gln Thr Val Ala Glu Val
     210                 215                 220                
 Ile Thr Glu Gln Ala Asn Leu Ser Val Ser Ala Ala Arg Ser Ser Lys
 225                 230                 235                 240
 Val Leu Tyr Val Ile Thr Thr Ser Pro Ser His Pro Pro Gln Thr Val
                 245                 250                 255    
 Pro Gly Trp Thr Val Tyr Gly Leu Ala Thr Leu Leu Ile Leu Thr Val
             260                 265                 270        
 Thr Ala Ile Val Ala Lys Ile Leu Leu His Val Thr Phe Lys
         275                 280                 285    



      <210> 695
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 695
 Met Ala Ala Ala Thr Glu Leu Asn Arg Pro Ser Ser Gly Asp Arg Asn
   1               5                  10                  15    
 Leu Glu Arg Arg Cys Ser Pro Asn Leu Ser Arg Glu Val Leu Tyr Glu
              20                  25                  30        
 Ile Phe Arg Ser Leu His Thr Leu Val Gly Gln Leu Asp Leu Arg Asp
          35                  40                  45            
 Asp Val Val Lys Ile Thr Ile Asp Trp Asn Lys Leu Gln Ser Leu Ser
      50                  55                  60                
 Ala Phe Gln Pro Ala Leu Leu Phe Ser Ala Leu Glu Gln His Ile Leu
  65                  70                  75                  80
 Tyr Leu Gln Pro Phe Leu Ala Lys Leu Gln Ser Pro Ile Lys Glu Glu
                  85                  90                  95    
 Asn Thr Thr Ala Val Glu Glu Ile Gly Arg Thr Glu Met Gly Asn Lys
             100                 105                 110        
 Asn Glu Val Asn Asp Lys Phe Ser Ile Gly Asp Leu Gln Glu Glu Glu
         115                 120                 125            
 Lys His Lys Glu Ser Asp Leu Arg Asp Val Lys Lys Thr Gln Ile His
     130                 135                 140                
 Phe Asp Pro Glu Val Val Gln Ile Lys Ala Gly Lys Ala Glu Ile Asp
 145                 150                 155                 160
 Arg Arg Ile Ser Ala Phe Ile Glu Arg Lys Gln Ala Glu Ile Asn Glu
                 165                 170                 175    
 Asn Asn Val Arg Glu Phe Cys Asn Val Ile Asp Cys Asn Gln Glu Asn
             180                 185                 190        
 Ser Cys Ala Arg Thr Asp Ala Ile Phe Thr Pro Tyr Pro Gly Phe Lys
         195                 200                 205            
 Ser His Val Lys Val Ser Arg Val Val Asn Thr Tyr Gly Pro Gln Thr
     210                 215                 220                
 Arg Pro Glu Gly Ile Pro Gly Ser Gly His Lys Pro Asn Ser Met Leu
 225                 230                 235                 240
 Arg Asp Cys Gly Asn Gln Ala Val Glu Glu Arg Leu Gln Asn Ile Glu
                 245                 250                 255    
 Ala His Leu Arg Leu Gln Thr Gly Gly Pro Val Pro Arg Asp Ile Tyr
             260                 265                 270        
 Gln Arg Ile Lys Lys Leu Glu Asp Lys Ile Leu Glu Leu Glu Gly Ile
         275                 280                 285            
 Ser Pro Glu Tyr Phe Gln Ser Val Ser Phe Ser Gly Lys Glu Glu Lys
     290                 295                 300                
 Phe Asn His Leu Asn Arg Thr Ile His Trp Leu Asn Leu Met Arg Lys
 305                 310                 315                 320
 Leu Val Pro Ser Asn Lys Pro Ser Ser Glu Asn Gln Glu Lys Gln Asn
                 325                 330                 335    
 Pro Trp Gln Pro Thr Thr Phe His Glu Lys Leu Leu Ser Ser Leu Ser
             340                 345                 350        
 Phe Tyr Phe Phe Val Tyr Ile Cys Val Thr Tyr Thr Val Ile Asn Ser
         355                 360                 365            
 Thr Asp Ile Tyr Leu Ser Met
     370                 375



      <210> 696
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 696
 Met Glu Ala Tyr Arg Thr Gln Asn Cys Phe Leu Asn Ser Glu Ile His
   1               5                  10                  15    
 Gln Val Thr Lys Ile Trp Arg Lys Val Ala Glu Lys Glu Lys Ala Leu
              20                  25                  30        
 Leu Thr Lys Cys Ala Tyr Leu Gln Ala Arg Asn Cys Gln Val Glu Ser
          35                  40                  45            
 Lys Tyr Leu Ala Gly Leu Arg Arg Leu Gln Glu Ala Leu Gly Asp Glu
      50                  55                  60                
 Ala Ser Glu Cys Ser Glu Leu Leu Arg Gln Leu Val Gln Glu Ala Leu
  65                  70                  75                  80
 Gln Trp Glu Ala Gly Glu Ala Ser Ser Asp Ser Ile Glu Leu Ser Pro
                  85                  90                  95    
 Ile Ser Lys Tyr Asp Glu Tyr Gly Phe Leu Thr Val Pro Asp Tyr Glu
             100                 105                 110        
 Val Glu Asp Leu Lys Leu Leu Ala Lys Ile Gln Ala Leu Glu Ser Arg
         115                 120                 125            
 Ser His His Leu Leu Gly Leu Glu Ala Val Asp Arg Pro Leu Arg Glu
     130                 135                 140                
 Arg Trp Ala Ala Leu Gly Asp Leu Val Pro Ser Ala Glu Leu Lys Gln
 145                 150                 155                 160
 Leu Leu Arg Ala Gly Val Pro Arg Glu His Arg Pro Arg Val Trp Arg
                 165                 170                 175    
 Trp Leu Val His Leu Arg Val Gln His Leu His Thr Pro Gly Cys Tyr
             180                 185                 190        
 Gln Glu Leu Leu Ser Arg Gly Gln Ala Arg Glu His Pro Ala Ala Arg
         195                 200                 205            
 Gln Ile Glu Leu Asp Leu Asn Arg Thr Phe Pro Asn Asn Lys His Phe
     210                 215                 220                
 Thr Cys Pro Thr Ser Ser Phe Pro Asp Lys Leu Arg Arg Val Leu Leu
 225                 230                 235                 240
 Ala Phe Ser Trp Gln Asn Pro Thr Ile Gly Tyr Cys Gln Gly Leu Asn
                 245                 250                 255    
 Arg Leu Ala Ala Ile Ala Leu Leu Val Leu Glu Glu Glu Glu Ser Ala
             260                 265                 270        
 Phe Trp Cys Leu Val Ala Ile Val Glu Thr Ile Met Pro Ala Asp Tyr
         275                 280                 285            
 Tyr Cys Asn Thr Leu Thr Ala Ser Gln Val Asp Gln Arg Val Leu Gln
     290                 295                 300                
 Asp Leu Leu Ser Glu Lys Leu Pro Arg Leu Met Ala His Leu Gly Gln
 305                 310                 315                 320
 His His Val Asp Leu Ser Leu Val Thr Phe Asn Trp Phe Leu Val Val
                 325                 330                 335    
 Phe Ala Asp Ser Leu Ile Ser Asn Ile Leu Leu Arg Val Trp Asp Ala
             340                 345                 350        
 Phe Leu Tyr Glu Gly Thr Lys Val Val Phe Arg Tyr Ala Leu Ala Ile
         355                 360                 365            
 Phe Lys Tyr Asn Glu Lys Glu Ile Leu Arg Leu Gln Asn Gly Leu Glu
     370                 375                 380                
 Ile Tyr Gln Tyr Leu Arg Phe Phe Thr Lys Thr Ile Ser Asn Ser Arg
 385                 390                 395                 400
 Lys Leu Met Asn Ile Ala Phe Asn Asp Met Asn Pro Phe Arg Met Lys
                 405                 410                 415    
 Gln Leu Arg Gln Leu Arg Met Val His Arg Glu Arg Leu Glu Ala Glu
             420                 425                 430        
 Leu Arg Glu Leu Glu Gln Leu Lys Ala Glu Tyr Leu Glu Arg Arg Ala
         435                 440                 445            
 Ser Arg Arg Arg Ala Val Ser Glu Gly Cys Ala Ser Glu Asp Glu Val
     450                 455                 460                
 Glu Gly Glu Ala
 465            



      <210> 697
      <211> 302
      <212> PRT
      <213> Homo sapiens


      <400> 697
 Met His Leu Leu Leu Gly Gly Arg Thr Trp Arg Ala Ala Arg Ala Ala
   1               5                  10                  15    
 Asp Gly Cys Glu Ala Leu Gly Thr Gly Val Leu Met Ala Asn Phe Lys
              20                  25                  30        
 Gly His Ala Leu Pro Gly Ser Phe Phe Leu Ile Ile Gly Leu Cys Trp
          35                  40                  45            
 Ser Val Lys Tyr Pro Leu Lys Tyr Phe Ser His Thr Arg Lys Asn Ser
      50                  55                  60                
 Pro Leu His Tyr Tyr Gln Arg Leu Glu Ile Val Glu Ala Ala Ile Arg
  65                  70                  75                  80
 Thr Leu Phe Ser Val Thr Gly Ile Leu Ala Glu Gln Phe Val Pro Asp
                  85                  90                  95    
 Gly Pro His Leu His Leu Tyr His Glu Asn His Trp Ile Lys Leu Met
             100                 105                 110        
 Asn Trp Gln His Ser Thr Met Tyr Leu Phe Phe Ala Val Ser Gly Ile
         115                 120                 125            
 Val Asp Met Leu Thr Tyr Leu Val Ser His Val Pro Leu Gly Val Asp
     130                 135                 140                
 Arg Leu Val Met Ala Val Ala Val Phe Met Glu Gly Phe Leu Phe Tyr
 145                 150                 155                 160
 Tyr His Val His Asn Arg Pro Pro Leu Asp Gln His Ile His Ser Leu
                 165                 170                 175    
 Leu Leu Tyr Ala Leu Phe Gly Gly Cys Val Ser Ile Ser Leu Glu Val
             180                 185                 190        
 Ile Phe Arg Asp His Ile Val Leu Glu Leu Phe Arg Thr Ser Leu Ile
         195                 200                 205            
 Ile Leu Gln Gly Thr Trp Phe Trp Gln Ile Gly Phe Val Leu Phe Pro
     210                 215                 220                
 Pro Phe Gly Thr Pro Glu Trp Asp Gln Lys Asp Asp Ala Asn Leu Met
 225                 230                 235                 240
 Phe Ile Thr Met Cys Phe Cys Trp His Tyr Leu Ala Ala Leu Ser Ile
                 245                 250                 255    
 Val Ala Val Asn Tyr Phe Leu Val Tyr Cys Leu Leu Thr Arg Met Lys
             260                 265                 270        
 Arg His Gly Arg Gly Glu Ile Ile Gly Ile Gln Lys Leu Asn Ser Asp
         275                 280                 285            
 Asp Pro Tyr Gln Thr Ala Leu Leu Ser Gly Ser Asp Glu Glu
     290                 295                 300        



      <210> 698
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 698
 Met Thr Gln Pro Val Pro Arg Leu Ser Val Pro Ala Ala Leu Ala Leu
   1               5                  10                  15    
 Gly Ser Ala Ala Leu Gly Ala Ala Phe Ala Thr Gly Leu Phe Leu Gly
              20                  25                  30        
 Arg Arg Cys Pro Pro Trp Arg Gly Arg Arg Glu Gln Cys Leu Leu Pro
          35                  40                  45            
 Pro Glu Asp Ser Arg Leu Trp Gln Tyr Leu Leu Ser Arg Ser Met Arg
      50                  55                  60                
 Glu His Pro Ala Leu Arg Ser Leu Arg Leu Leu Thr Leu Glu Gln Pro
  65                  70                  75                  80
 Gln Gly Asp Ser Met Met Thr Cys Glu Gln Ala Gln Leu Leu Ala Asn
                  85                  90                  95    
 Leu Ala Arg Leu Ile Gln Ala Lys Lys Ala Leu Asp Leu Gly Thr Phe
             100                 105                 110        
 Thr Gly Tyr Ser Ala Leu Ala Leu Ala Leu Ala Leu Pro Ala Asp Gly
         115                 120                 125            
 Arg Val Val Thr Cys Glu Val Asp Ala Gln Pro Pro Glu Leu Gly Arg
     130                 135                 140                
 Pro Leu Trp Arg Gln Ala Glu Ala Glu His Lys Ile Asp Leu Arg Leu
 145                 150                 155                 160
 Lys Pro Ala Leu Glu Thr Leu Asp Glu Leu Leu Ala Ala Gly Glu Ala
                 165                 170                 175    
 Gly Thr Phe Asp Val Ala Val Val Asp Ala Asp Lys Glu Asn Cys Ser
             180                 185                 190        
 Ala Tyr Tyr Glu Arg Cys Leu Gln Leu Leu Arg Pro Gly Gly Ile Leu
         195                 200                 205            
 Ala Val Leu Arg Val Leu Trp Arg Gly Lys Val Leu Gln Pro Pro Lys
     210                 215                 220                
 Gly Asp Val Ala Ala Glu Cys Val Arg Asn Leu Asn Glu Arg Ile Arg
 225                 230                 235                 240
 Arg Asp Val Arg Val Tyr Ile Ser Leu Leu Pro Leu Gly Asp Gly Leu
                 245                 250                 255    
 Thr Leu Ala Phe Lys Ile
             260        



      <210> 699
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 699
 Met Glu Ser Ser Arg Gly Arg Pro Gly Pro Glu Thr Asp Leu Leu Ala
   1               5                  10                  15    
 Val Ala Glu His Gln Ala Leu Val Phe Gly Gly Gly Pro Gly Arg Thr
              20                  25                  30        
 Ser Ser Glu Pro Pro Ala Gly Leu Arg Val Ser Gly Glu Glu Glu Thr
          35                  40                  45            
 Glu Asn Val Gly Gly Ala Asn Arg His Pro Arg Thr Ser Pro Lys Thr
      50                  55                  60                
 Ser Ser Cys Gly Val Val His Arg Pro Glu Arg Glu Ala Leu Glu Asn
  65                  70                  75                  80
 Glu Pro Gly Pro Gln Gly Thr Leu Ser Gly Ala Gly Ser Arg Arg Gly
                  85                  90                  95    
 Ala Pro Gly Ala Glu His Glu Pro Ser Leu Ser Ser Arg His Lys Asn
             100                 105                 110        
 Pro Ala Pro Pro Glu Gly Lys Pro Ser Ser Gly Arg Asp Cys Arg Arg
         115                 120                 125            
 Gly Gly Pro Gly Gly Gly Met Asp Val Glu Gln Gln Glu Glu Glu Asp
     130                 135                 140                
 Asn Asp Glu Glu Ala Ala Ala Gly Ser Arg Ala Gly Arg Ser Phe Ser
 145                 150                 155                 160
 Ser Arg Leu Gln Asp Ser Arg Ser Leu Asp Gly Leu Ser Glu Ala Cys
                 165                 170                 175    
 Gly Gly Ala Gly Ser Ser Gly Ser Ala Glu Ser Gly Ala Gly Gly Gly
             180                 185                 190        
 Arg Arg Ala Thr Ile Ser Ser Pro Leu Glu Leu Glu Gly Thr Val Ser
         195                 200                 205            
 Arg His Gly Asp Leu Thr His Phe Val Ala Asn Asn Leu Gln Leu Lys
     210                 215                 220                
 Ile Arg Leu Ser Gly Ala Pro Pro Pro Pro Pro Ser Ala Pro Ala Arg
 225                 230                 235                 240
 Pro Cys Pro Ala Pro Ala Pro Thr Pro Thr Pro Ala Ile Pro Pro Ile
                 245                 250                 255    
 Asp Pro Glu Val Leu Arg Asp Leu Glu Arg Leu Ser Arg Glu Leu Gly
             260                 265                 270        
 Gly Arg Val Asp Arg Leu Leu Arg Gly Leu Gly Gly Ala Val Gln Glu
         275                 280                 285            
 Leu Thr Ala Leu Ser Val Gly Cys Ile Gln Thr Tyr Arg Asp Ala Val
     290                 295                 300                
 Asp Ser Leu Gly Glu Ala Val Asp Met Ser Ile Lys Gly Met Tyr Thr
 305                 310                 315                 320
 Leu Leu Ala Arg Cys Glu Glu Leu Glu Arg Ala Leu Gln Pro Val Gln
                 325                 330                 335    
 Gly Leu Ala Arg Gln Val Arg Asp Ile Arg Arg Thr Leu Glu Val Leu
             340                 345                 350        
 Glu Ala Leu Cys Lys
         355        



      <210> 700
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 700
 Met Ala Val Pro Thr Glu Leu Asp Gly Gly Ser Val Lys Glu Thr Ala
   1               5                  10                  15    
 Ala Glu Glu Glu Ser Arg Val Leu Ala Pro Gly Ala Ala Pro Phe Gly
              20                  25                  30        
 Asn Phe Pro His Tyr Ser Arg Phe His Pro Pro Glu Gln Arg Leu Arg
          35                  40                  45            
 Leu Leu Pro Pro Glu Leu Leu Arg Gln Leu Phe Pro Glu Ser Pro Glu
      50                  55                  60                
 Asn Gly Pro Ile Leu Gly Leu Asp Val Gly Cys Asn Ser Gly Asp Leu
  65                  70                  75                  80
 Ser Val Ala Leu Tyr Lys His Phe Leu Ser Leu Pro Asp Gly Glu Thr
                  85                  90                  95    
 Cys Ser Asp Ala Ser Arg Glu Phe Arg Leu Leu Cys Cys Asp Ile Asp
             100                 105                 110        
 Pro Val Leu Val Lys Arg Ala Glu Lys Glu Cys Pro Phe Pro Asp Ala
         115                 120                 125            
 Leu Thr Phe Ile Thr Leu Asp Phe Met Asn Gln Arg Thr Arg Lys Val
     130                 135                 140                
 Leu Leu Ser Ser Phe Leu Ser Gln Phe Gly Arg Ser Val Phe Asp Ile
 145                 150                 155                 160
 Gly Phe Cys Met Ser Ile Thr Met Trp Ile His Leu Asn His Gly Asp
                 165                 170                 175    
 His Gly Leu Trp Glu Phe Leu Ala His Leu Ser Ser Leu Cys His Tyr
             180                 185                 190        
 Leu Leu Val Glu Pro Gln Pro Trp Lys Cys Tyr Arg Ala Ala Ala Arg
         195                 200                 205            
 Arg Leu Arg Lys Leu Gly Leu His Asp Phe Asp His Phe His Ser Leu
     210                 215                 220                
 Ala Ile Arg Gly Asp Met Pro Asn Gln Ile Val Gln Ile Leu Thr Gln
 225                 230                 235                 240
 Asp His Gly Met Glu Leu Ile Cys Cys Phe Gly Asn Thr Ser Trp Asp
                 245                 250                 255    
 Arg Ser Leu Leu Leu Phe Arg Ala Lys Gln Thr Ile Glu Thr His Pro
             260                 265                 270        
 Ile Pro Glu Ser Leu Ile Glu Lys Gly Lys Glu Lys Asn Arg Leu Ser
         275                 280                 285            
 Phe Gln Lys Gln
     290        



      <210> 701
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 701
 Met Ala Ser Tyr Phe Asp Glu His Asp Cys Glu Pro Ser Asp Pro Glu
   1               5                  10                  15    
 Gln Glu Thr Arg Thr Asn Met Leu Leu Glu Leu Ala Arg Ser Leu Phe
              20                  25                  30        
 Asn Arg Met Asp Phe Glu Asp Leu Gly Leu Val Val Asp Trp Asp His
          35                  40                  45            
 His Leu Pro Pro Pro Ala Ala Lys Thr Val Val Glu Asn Leu Pro Arg
      50                  55                  60                
 Thr Val Ile Arg Gly Ser Gln Ala Glu Leu Lys Cys Pro Val Cys Leu
  65                  70                  75                  80
 Leu Glu Phe Glu Glu Glu Glu Thr Ala Ile Glu Met Pro Cys His His
                  85                  90                  95    
 Leu Phe His Ser Ser Cys Ile Leu Pro Trp Leu Ser Lys Thr Asn Ser
             100                 105                 110        
 Cys Pro Leu Cys Arg Tyr Glu Leu Pro Thr Asp Asp Asp Thr Tyr Glu
         115                 120                 125            
 Glu His Arg Arg Asp Lys Ala Arg Lys Gln Gln Gln Gln His Arg Leu
     130                 135                 140                
 Glu Asn Leu His Gly Ala Met Tyr Thr
 145                 150            



      <210> 702
      <211> 1032
      <212> PRT
      <213> Homo sapiens


      <400> 702
 Met Gly Phe Cys Arg Ser Ala Leu His Pro Leu Ser Leu Leu Val Gln
   1               5                  10                  15    
 Ala Ile Met Leu Ala Met Thr Leu Ala Leu Gly Thr Leu Pro Ala Phe
              20                  25                  30        
 Leu Pro Cys Glu Leu Gln Pro His Gly Leu Val Asn Cys Asn Trp Leu
          35                  40                  45            
 Phe Leu Lys Ser Val Pro His Phe Ser Met Ala Ala Pro Arg Gly Asn
      50                  55                  60                
 Val Thr Ser Leu Ser Leu Ser Ser Asn Arg Ile His His Leu His Asp
  65                  70                  75                  80
 Ser Asp Phe Ala His Leu Pro Ser Leu Arg His Leu Asn Leu Lys Trp
                  85                  90                  95    
 Asn Cys Pro Pro Val Gly Leu Ser Pro Met His Phe Pro Cys His Met
             100                 105                 110        
 Thr Ile Glu Pro Ser Thr Phe Leu Ala Val Pro Thr Leu Glu Glu Leu
         115                 120                 125            
 Asn Leu Ser Tyr Asn Asn Ile Met Thr Val Pro Ala Leu Pro Lys Ser
     130                 135                 140                
 Leu Ile Ser Leu Ser Leu Ser His Thr Asn Ile Leu Met Leu Asp Ser
 145                 150                 155                 160
 Ala Ser Leu Ala Gly Leu His Ala Leu Arg Phe Leu Phe Met Asp Gly
                 165                 170                 175    
 Asn Cys Tyr Tyr Lys Asn Pro Cys Arg Gln Ala Leu Glu Val Ala Pro
             180                 185                 190        
 Gly Ala Leu Leu Gly Leu Gly Asn Leu Thr His Leu Ser Leu Lys Tyr
         195                 200                 205            
 Asn Asn Leu Thr Val Val Pro Arg Asn Leu Pro Ser Ser Leu Glu Tyr
     210                 215                 220                
 Leu Leu Leu Ser Tyr Asn Arg Ile Val Lys Leu Ala Pro Glu Asp Leu
 225                 230                 235                 240
 Ala Asn Leu Thr Ala Leu Arg Val Leu Asp Val Gly Gly Asn Cys Arg
                 245                 250                 255    
 Arg Cys Asp His Ala Pro Asn Pro Cys Met Glu Cys Pro Arg His Phe
             260                 265                 270        
 Pro Gln Leu His Pro Asp Thr Phe Ser His Leu Ser Arg Leu Glu Gly
         275                 280                 285            
 Leu Val Leu Lys Asp Ser Ser Leu Ser Trp Leu Asn Ala Ser Trp Phe
     290                 295                 300                
 Arg Gly Leu Gly Asn Leu Arg Val Leu Asp Leu Ser Glu Asn Phe Leu
 305                 310                 315                 320
 Tyr Lys Cys Ile Thr Lys Thr Lys Ala Phe Gln Gly Leu Thr Gln Leu
                 325                 330                 335    
 Arg Lys Leu Asn Leu Ser Phe Asn Tyr Gln Lys Arg Val Ser Phe Ala
             340                 345                 350        
 His Leu Ser Leu Ala Pro Ser Phe Gly Ser Leu Val Ala Leu Lys Glu
         355                 360                 365            
 Leu Asp Met His Gly Ile Phe Phe Arg Ser Leu Asp Glu Thr Thr Leu
     370                 375                 380                
 Arg Pro Leu Ala Arg Leu Pro Met Leu Gln Thr Leu Arg Leu Gln Met
 385                 390                 395                 400
 Asn Phe Ile Asn Gln Ala Gln Leu Gly Ile Phe Arg Ala Phe Pro Gly
                 405                 410                 415    
 Leu Arg Tyr Val Asp Leu Ser Asp Asn Arg Ile Ser Gly Ala Ser Glu
             420                 425                 430        
 Leu Thr Ala Thr Met Gly Glu Ala Asp Gly Gly Glu Lys Val Trp Leu
         435                 440                 445            
 Gln Pro Gly Asp Leu Ala Pro Ala Pro Val Asp Thr Pro Ser Ser Glu
     450                 455                 460                
 Asp Phe Arg Pro Asn Cys Ser Thr Leu Asn Phe Thr Leu Asp Leu Ser
 465                 470                 475                 480
 Arg Asn Asn Leu Val Thr Val Gln Pro Glu Met Phe Ala Gln Leu Ser
                 485                 490                 495    
 His Leu Gln Cys Leu Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val
             500                 505                 510        
 Asn Gly Ser Gln Phe Leu Pro Leu Thr Gly Leu Gln Val Leu Asp Leu
         515                 520                 525            
 Ser His Asn Lys Leu Asp Leu Tyr His Glu His Ser Phe Thr Glu Leu
     530                 535                 540                
 Pro Arg Leu Glu Ala Leu Asp Leu Ser Tyr Asn Ser Gln Pro Phe Gly
 545                 550                 555                 560
 Met Gln Gly Val Gly His Asn Phe Ser Phe Val Ala His Leu Arg Thr
                 565                 570                 575    
 Leu Arg His Leu Ser Leu Ala His Asn Asn Ile His Ser Gln Val Ser
             580                 585                 590        
 Gln Gln Leu Cys Ser Thr Ser Leu Arg Ala Leu Asp Phe Ser Gly Asn
         595                 600                 605            
 Ala Leu Gly His Met Trp Ala Glu Gly Asp Leu Tyr Leu His Phe Phe
     610                 615                 620                
 Gln Gly Leu Ser Gly Leu Ile Trp Leu Asp Leu Ser Gln Asn Arg Leu
 625                 630                 635                 640
 His Thr Leu Leu Pro Gln Thr Leu Arg Asn Leu Pro Lys Ser Leu Gln
                 645                 650                 655    
 Val Leu Arg Leu Arg Asp Asn Tyr Leu Ala Phe Phe Lys Trp Trp Ser
             660                 665                 670        
 Leu His Phe Leu Pro Lys Leu Glu Val Leu Asp Leu Ala Gly Asn Gln
         675                 680                 685            
 Leu Lys Ala Leu Thr Asn Gly Ser Leu Pro Ala Gly Thr Arg Leu Arg
     690                 695                 700                
 Arg Leu Asp Val Ser Cys Asn Ser Ile Ser Phe Val Ala Pro Gly Phe
 705                 710                 715                 720
 Phe Ser Lys Ala Lys Glu Leu Arg Glu Leu Asn Leu Ser Ala Asn Ala
                 725                 730                 735    
 Leu Lys Thr Val Asp His Ser Trp Phe Gly Pro Leu Ala Ser Ala Leu
             740                 745                 750        
 Gln Ile Leu Asp Val Ser Ala Asn Pro Leu His Cys Ala Cys Gly Ala
         755                 760                 765            
 Ala Phe Met Asp Phe Leu Leu Glu Val Gln Ala Ala Val Pro Gly Leu
     770                 775                 780                
 Pro Ser Arg Val Lys Cys Gly Ser Pro Gly Gln Leu Gln Gly Leu Ser
 785                 790                 795                 800
 Ile Phe Ala Gln Asp Leu Arg Leu Cys Leu Asp Glu Ala Leu Ser Trp
                 805                 810                 815    
 Asp Cys Phe Ala Leu Ser Leu Leu Ala Val Ala Leu Gly Leu Gly Val
             820                 825                 830        
 Pro Met Leu His His Leu Cys Gly Trp Asp Leu Trp Tyr Cys Phe His
         835                 840                 845            
 Leu Cys Leu Ala Trp Leu Pro Trp Arg Gly Arg Gln Ser Gly Arg Asp
     850                 855                 860                
 Glu Asp Ala Leu Pro Tyr Asp Ala Phe Val Val Phe Asp Lys Thr Gln
 865                 870                 875                 880
 Ser Ala Val Ala Asp Trp Val Tyr Asn Glu Leu Arg Gly Gln Leu Glu
                 885                 890                 895    
 Glu Cys Arg Gly Arg Trp Ala Leu Arg Leu Cys Leu Glu Glu Arg Asp
             900                 905                 910        
 Trp Leu Pro Gly Lys Thr Leu Phe Glu Asn Leu Trp Ala Ser Val Tyr
         915                 920                 925            
 Gly Ser Arg Lys Thr Leu Phe Val Leu Ala His Thr Asp Arg Val Ser
     930                 935                 940                
 Gly Leu Leu Arg Ala Ser Phe Leu Leu Ala Gln Gln Arg Leu Leu Glu
 945                 950                 955                 960
 Asp Arg Lys Asp Val Val Val Leu Val Ile Leu Ser Pro Asp Gly Arg
                 965                 970                 975    
 Arg Ser Arg Tyr Val Arg Leu Arg Gln Arg Leu Cys Arg Gln Ser Val
             980                 985                 990        
 Leu Leu Trp Pro His Gln Pro Ser Gly Gln Arg Ser Phe Trp Ala Gln
         995                1000                1005            
 Leu Gly Met Ala Leu Thr Arg Asp Asn His His Phe Tyr Asn Arg Asn
    1010                1015                1020                
 Phe Cys Gln Gly Pro Thr Ala Glu
1025                1030        



      <210> 703
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 703
 Met Lys Arg Val Leu Ser Cys Val Pro Glu Pro Thr Val Val Met Ala
   1               5                  10                  15    
 Ala Arg Ala Leu Cys Met Leu Gly Leu Val Leu Ala Leu Leu Ser Ser
              20                  25                  30        
 Ser Ser Ala Glu Glu Tyr Val Gly Leu Ser Ala Asn Gln Cys Ala Val
          35                  40                  45            
 Pro Ala Lys Asp Arg Val Asp Cys Gly Tyr Pro His Val Thr Pro Lys
      50                  55                  60                
 Glu Cys Asn Asn Arg Gly Cys Cys Phe Asp Ser Arg Ile Pro Gly Val
  65                  70                  75                  80
 Pro Cys Cys Phe Lys Pro Leu Gln Glu Ala Glu Cys Thr Phe
                  85                  90                



      <210> 704
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 704
 Met Gly Glu Pro Arg Ala Gly Ala Ala Leu Asp Asp Gly Ser Gly Trp
   1               5                  10                  15    
 Thr Gly Ser Glu Glu Gly Ser Glu Glu Gly Thr Gly Gly Ser Glu Gly
              20                  25                  30        
 Ala Gly Gly Asp Gly Gly Pro Asp Ala Glu Gly Val Trp Ser Pro Asp
          35                  40                  45            
 Ile Glu Gln Ser Phe Gln Glu Ala Leu Ala Ile Tyr Pro Pro Cys Gly
      50                  55                  60                
 Arg Arg Lys Ile Ile Leu Ser Asp Glu Gly Lys Met Tyr Gly Arg Asn
  65                  70                  75                  80
 Glu Leu Ile Ala Arg Tyr Ile Lys Leu Arg Thr Gly Lys Thr Arg Thr
                  85                  90                  95    
 Arg Lys Gln Val Ser Ser His Ile Gln Val Leu Ala Arg Arg Lys Ser
             100                 105                 110        
 Arg Glu Ile Gln Ser Lys Leu Lys Asp Gln Val Ser Lys Asp Lys Ala
         115                 120                 125            
 Phe Gln Thr Met Ala Thr Met Ser Ser Ala Gln Leu Ile Ser Ala Pro
     130                 135                 140                
 Ser Leu Gln Ala Lys Leu Gly Pro Thr Gly Pro Gln Ala Ser Glu Leu
 145                 150                 155                 160
 Phe Gln Phe Trp Ser Gly Gly Ser Gly Pro Pro Trp Asn Val Pro Asp
                 165                 170                 175    
 Val Lys Pro Phe Ser Gln Thr Pro Phe Thr Leu Ser Leu Thr Pro Pro
             180                 185                 190        
 Ser Thr Asp Leu Pro Gly Tyr Glu Pro Pro Gln Ala Leu Ser Pro Leu
         195                 200                 205            
 Pro Pro Pro Thr Pro Ser Pro Pro Ala Trp Gln Ala Arg Gly Leu Gly
     210                 215                 220                
 Thr Ala Arg Leu Gln Leu Val Glu Phe Ser Ala Phe Val Glu Pro Pro
 225                 230                 235                 240
 Asp Ala Val Asp Ser Tyr Gln Arg His Leu Phe Val His Ile Ser Gln
                 245                 250                 255    
 His Cys Pro Ser Pro Gly Ala Pro Pro Leu Glu Ser Val Asp Val Arg
             260                 265                 270        
 Gln Ile Tyr Asp Lys Phe Pro Glu Lys Lys Gly Gly Leu Arg Glu Leu
         275                 280                 285            
 Tyr Asp Arg Gly Pro Pro His Ala Phe Phe Leu Val Lys Phe Trp Ala
     290                 295                 300                
 Asp Leu Asn Trp Gly Pro Ser Gly Glu Glu Ala Gly Ala Gly Gly Ser
 305                 310                 315                 320
 Ile Ser Ser Gly Gly Phe Tyr Gly Val Ser Ser Gln Tyr Glu Ser Leu
                 325                 330                 335    
 Glu His Met Thr Leu Thr Cys Ser Ser Lys Val Cys Ser Phe Gly Lys
             340                 345                 350        
 Gln Val Val Glu Lys Val Glu Thr Glu Arg Ala Gln Leu Glu Asp Gly
         355                 360                 365            
 Arg Phe Val Tyr Arg Leu Leu Arg Ser Pro Met Cys Glu Tyr Leu Val
     370                 375                 380                
 Asn Phe Leu His Lys Leu Arg Gln Leu Pro Glu Arg Tyr Met Met Asn
 385                 390                 395                 400
 Ser Val Leu Glu Asn Phe Thr Ile Leu Gln Val Val Thr Asn Arg Asp
                 405                 410                 415    
 Thr Gln Glu Leu Leu Leu Cys Thr Ala Tyr Val Phe Glu Val Ser Thr
             420                 425                 430        
 Ser Glu Arg Gly Ala Gln His His Ile Tyr Arg Leu Val Arg Asp
         435                 440                 445        



      <210> 705
      <211> 698
      <212> PRT
      <213> Homo sapiens


      <400> 705
 Met Val Glu Lys Gly Ser Asp His Ser Ser Asp Lys Ser Pro Ser Thr
   1               5                  10                  15    
 Pro Glu Gln Gly Val Gln Arg Ser Cys Ser Ser Gln Ser Gly Arg Ser
              20                  25                  30        
 Gly Gly Lys Asn Ser Lys Lys Ser Gln Ser Trp Tyr Asn Val Leu Ser
          35                  40                  45            
 Pro Thr Tyr Lys Gln Arg Asn Glu Asp Phe Arg Lys Leu Phe Lys Gln
      50                  55                  60                
 Leu Pro Asp Thr Glu Arg Leu Ile Val Asp Tyr Ser Cys Ala Leu Gln
  65                  70                  75                  80
 Arg Asp Ile Leu Leu Gln Gly Arg Leu Tyr Leu Ser Glu Asn Trp Ile
                  85                  90                  95    
 Cys Phe Tyr Ser Asn Ile Phe Arg Trp Glu Thr Leu Leu Thr Val Arg
             100                 105                 110        
 Leu Lys Asp Ile Cys Ser Met Thr Lys Glu Lys Thr Ala Arg Leu Ile
         115                 120                 125            
 Pro Asn Ala Ile Gln Val Cys Thr Asp Ser Glu Lys His Phe Phe Thr
     130                 135                 140                
 Ser Phe Gly Ala Arg Asp Arg Thr Tyr Met Met Met Phe Arg Leu Trp
 145                 150                 155                 160
 Gln Asn Ala Leu Leu Glu Lys Pro Leu Cys Pro Lys Glu Leu Trp His
                 165                 170                 175    
 Phe Val His Gln Cys Tyr Gly Asn Glu Leu Gly Leu Thr Ser Asp Asp
             180                 185                 190        
 Glu Asp Tyr Val Pro Pro Asp Asp Asp Phe Asn Thr Met Gly Tyr Cys
         195                 200                 205            
 Glu Glu Ile Pro Val Glu Glu Asn Glu Val Asn Asp Ser Ser Ser Lys
     210                 215                 220                
 Ser Ser Ile Glu Thr Lys Pro Asp Ala Ser Pro Gln Leu Pro Lys Lys
 225                 230                 235                 240
 Ser Ile Thr Asn Ser Thr Leu Thr Ser Thr Gly Ser Ser Glu Ala Pro
                 245                 250                 255    
 Val Ser Phe Asp Gly Leu Pro Leu Glu Glu Glu Ala Leu Glu Gly Asp
             260                 265                 270        
 Gly Ser Leu Glu Lys Glu Leu Ala Ile Asp Asn Ile Met Gly Glu Lys
         275                 280                 285            
 Ile Glu Met Ile Ala Pro Val Asn Ser Pro Ser Leu Asp Phe Asn Asp
     290                 295                 300                
 Asn Glu Asp Ile Pro Thr Glu Leu Ser Asp Ser Ser Asp Thr His Asp
 305                 310                 315                 320
 Glu Gly Glu Val Gln Ala Phe Tyr Glu Asp Leu Ser Gly Arg Gln Tyr
                 325                 330                 335    
 Val Asn Glu Val Phe Asn Phe Ser Val Asp Lys Leu Tyr Asp Leu Leu
             340                 345                 350        
 Phe Thr Asn Ser Pro Phe Gln Arg Asp Phe Met Glu Gln Arg Arg Phe
         355                 360                 365            
 Ser Asp Ile Ile Phe His Pro Trp Lys Lys Glu Glu Asn Gly Asn Gln
     370                 375                 380                
 Ser Arg Val Ile Leu Tyr Thr Ile Thr Leu Thr Asn Pro Leu Ala Pro
 385                 390                 395                 400
 Lys Thr Ala Thr Val Arg Glu Thr Gln Thr Met Tyr Lys Ala Ser Gln
                 405                 410                 415    
 Glu Ser Glu Cys Tyr Val Ile Asp Ala Glu Val Leu Thr His Asp Val
             420                 425                 430        
 Pro Tyr His Asp Tyr Phe Tyr Thr Ile Asn Arg Tyr Thr Leu Thr Arg
         435                 440                 445            
 Val Ala Arg Asn Lys Ser Arg Leu Arg Val Ser Thr Glu Leu Arg Tyr
     450                 455                 460                
 Arg Lys Gln Pro Trp Gly Leu Val Lys Thr Phe Ile Glu Lys Asn Phe
 465                 470                 475                 480
 Trp Ser Gly Leu Glu Asp Tyr Phe Arg His Leu Glu Ser Glu Leu Ala
                 485                 490                 495    
 Lys Thr Glu Ser Thr Tyr Leu Ala Glu Met His Arg Gln Ser Pro Lys
             500                 505                 510        
 Glu Lys Ala Ser Lys Thr Thr Thr Val Arg Arg Arg Lys Arg Pro His
         515                 520                 525            
 Ala His Leu Arg Val Pro His Leu Glu Glu Val Met Ser Pro Val Thr
     530                 535                 540                
 Thr Pro Thr Asp Glu Asp Val Gly His Arg Ile Lys His Val Ala Gly
 545                 550                 555                 560
 Ser Thr Gln Thr Arg His Ile Pro Glu Asp Thr Pro Asn Gly Phe His
                 565                 570                 575    
 Leu Gln Ser Val Ser Lys Leu Leu Leu Val Ile Ser Cys Val Ile Cys
             580                 585                 590        
 Phe Ser Leu Val Leu Leu Val Ile Leu Asn Met Met Leu Phe Tyr Lys
         595                 600                 605            
 Leu Trp Met Leu Glu Tyr Thr Thr Gln Thr Leu Thr Ala Trp Gln Gly
     610                 615                 620                
 Leu Arg Leu Gln Glu Arg Leu Pro Gln Ser Gln Thr Glu Trp Ala Gln
 625                 630                 635                 640
 Leu Leu Glu Ser Gln Gln Lys Tyr His Asp Thr Glu Leu Gln Lys Trp
                 645                 650                 655    
 Arg Glu Ile Ile Lys Ser Ser Val Met Leu Leu Asp Gln Met Lys Asp
             660                 665                 670        
 Ser Leu Ile Asn Leu Gln Asn Gly Ile Arg Ser Arg Asp Tyr Thr Ser
         675                 680                 685            
 Glu Ser Glu Glu Lys Arg Asn Arg Tyr His
     690                 695            



      <210> 706
      <211> 828
      <212> PRT
      <213> Homo sapiens


      <400> 706
 Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro
   1               5                  10                  15    
 Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala
              20                  25                  30        
 Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe
          35                  40                  45            
 Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly
      50                  55                  60                
 Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly
  65                  70                  75                  80
 Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile
                  85                  90                  95    
 Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr
             100                 105                 110        
 Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp
         115                 120                 125            
 Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu
     130                 135                 140                
 Asn Val Tyr Val Pro Thr Glu Asp Gly Ser Gly Ala Lys Lys Gln Gly
 145                 150                 155                 160
 Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu Asp Ile Arg Asp
                 165                 170                 175    
 Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met
             180                 185                 190        
 Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly
         195                 200                 205            
 Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe
     210                 215                 220                
 Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp
 225                 230                 235                 240
 Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly
                 245                 250                 255    
 Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser
             260                 265                 270        
 Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln
         275                 280                 285            
 Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn
     290                 295                 300                
 Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys
 305                 310                 315                 320
 Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser
                 325                 330                 335    
 Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val
             340                 345                 350        
 Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu
         355                 360                 365            
 Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly
     370                 375                 380                
 Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro
 385                 390                 395                 400
 Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe
                 405                 410                 415    
 Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu
             420                 425                 430        
 Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu
         435                 440                 445            
 Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val
     450                 455                 460                
 Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro
 465                 470                 475                 480
 Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro
                 485                 490                 495    
 Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly
             500                 505                 510        
 Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys
         515                 520                 525            
 Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe
     530                 535                 540                
 Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe
 545                 550                 555                 560
 Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr
                 565                 570                 575    
 Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val
             580                 585                 590        
 Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val
         595                 600                 605            
 Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr
     610                 615                 620                
 Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg
 625                 630                 635                 640
 Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro
                 645                 650                 655    
 Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp
             660                 665                 670        
 Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu
         675                 680                 685            
 Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu
     690                 695                 700                
 Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro
 705                 710                 715                 720
 Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly
                 725                 730                 735    
 Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His
             740                 745                 750        
 His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala
         755                 760                 765            
 Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro
     770                 775                 780                
 Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly
 785                 790                 795                 800
 Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser
                 805                 810                 815    
 Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val
             820                 825            



      <210> 707
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 707
 Met Asp Ala His Glu Ile Trp Cys Gly Asp Ser Asp Arg Gly Thr Ser
   1               5                  10                  15    
 Leu Gly Arg Ser Ile Pro Cys Pro Pro Val Leu Cys Ser Val Arg Lys
              20                  25                  30        
 Ser His Leu Arg Pro Gln Val Leu Arg Pro Thr Arg Pro Arg Asn Ile
          35                  40                  45            
 Ser Pro Ile Ser Asn Pro Glu Leu Ala Thr Leu Ala Gly Asn Leu Ala
      50                  55                  60                
 Thr Gly Pro Arg Asn Ala Arg Ser Pro Gly Phe Leu Leu Ser Arg Val
  65                  70                  75                  80
 Pro Ser Val Trp Asp Pro Thr Glu Asn Arg Thr Val Gln Leu Thr Trp
                  85                  90                  95    
 Gln Pro Leu Pro Glu Pro Leu Glu Leu Trp Pro Lys Ala Leu
             100                 105                 110



      <210> 708
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 708
 Met Ile Arg Gln Glu Arg Ser Thr Ser Tyr Gln Glu Leu Ser Glu Glu
   1               5                  10                  15    
 Leu Val Gln Val Val Glu Asn Ser Glu Leu Ala Asp Glu Gln Asp Lys
              20                  25                  30        
 Glu Thr Val Arg Val Gln Gly Pro Gly Ile Leu Pro Gly Leu Asp Ser
          35                  40                  45            
 Glu Ser Ala Ser Ser Ser Ile Arg Phe Ser Lys Ala Cys Leu Lys Asn
      50                  55                  60                
 Val Phe Ser Val Leu Leu Ile Phe Ile Tyr Leu Leu Leu Met Ala Val
  65                  70                  75                  80
 Ala Val Phe Leu Val Tyr Arg Thr Ile Thr Asp Phe Arg Glu Lys Leu
                  85                  90                  95    
 Lys His Pro Val Met Ser Val Ser Tyr Lys Glu Val Asp Arg Tyr Asp
             100                 105                 110        
 Ala Pro Gly Ile Ala Leu Tyr Pro Gly Gln Ala Gln Leu Leu Ser Cys
         115                 120                 125            
 Lys His His Tyr Glu Val Ile Pro Pro Leu Thr Ser Pro Gly Gln Pro
     130                 135                 140                
 Gly Asp Met Asn Cys Thr Thr Gln Arg Ile Asn Tyr Thr Asp Pro Phe
 145                 150                 155                 160
 Ser Asn Gln Thr Val Lys Ser Ala Leu Ile Val Gln Gly Pro Arg Glu
                 165                 170                 175    
 Val Lys Lys Arg Glu Leu Val Phe Leu Gln Phe Arg Leu Asn Lys Ser
             180                 185                 190        
 Ser Glu Asp Phe Ser Ala Ile Asp Tyr Leu Leu Phe Ser Ser Phe Gln
         195                 200                 205            
 Glu Phe Leu Gln Ser Pro Asn Arg Val Gly Phe Met Gln Ala Cys Glu
     210                 215                 220                
 Ser Ala Tyr Ser Ser Trp Lys Phe Ser Gly Gly Phe Arg Thr Trp Val
 225                 230                 235                 240
 Lys Met Ser Leu Val Lys Thr Lys Glu Glu Asp Gly Arg Glu Ala Val
                 245                 250                 255    
 Glu Phe Arg Gln Glu Thr Ser Val Val Asn Tyr Ile Asp Gln Arg Pro
             260                 265                 270        
 Ala Ala Lys Lys Ser Ala Gln Leu Phe Phe Val Val Phe Glu Trp Lys
         275                 280                 285            
 Asp Pro Phe Ile Gln Lys Val Gln Asp Ile Val Thr Ala Asn Pro Trp
     290                 295                 300                
 Asn Thr Ile Ala Leu Leu Cys Gly Ala Phe Leu Ala Leu Phe Lys Ala
 305                 310                 315                 320
 Ala Glu Phe Ala Lys Leu Ser Ile Lys Trp Met Ile Lys Ile Arg Lys
                 325                 330                 335    
 Arg Tyr Leu Lys Arg Arg Gly Gln Ala Thr Ser His Ile Ser
             340                 345                 350



      <210> 709
      <211> 506
      <212> PRT
      <213> Homo sapiens


      <400> 709
 Met Lys Lys Ala Glu Met Gly Arg Phe Ser Ile Ser Pro Asp Glu Asp
   1               5                  10                  15    
 Ser Ser Ser Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr
              20                  25                  30        
 Lys Gln Ala Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn
          35                  40                  45            
 Gln Asn Phe Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr
      50                  55                  60                
 Glu Phe His Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu
  65                  70                  75                  80
 Ser Asn Ala Ile Val Gly Ser Gly Ile Leu Gly Leu Ser Tyr Ala Met
                  85                  90                  95    
 Ala Asn Thr Gly Ile Ala Leu Phe Ile Ile Leu Leu Thr Phe Val Ser
             100                 105                 110        
 Ile Phe Ser Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu
         115                 120                 125            
 Gly Gly Ser Leu Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu
     130                 135                 140                
 Val Gly Lys Leu Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly
 145                 150                 155                 160
 Ala Met Ser Ser Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val
                 165                 170                 175    
 Ile Gln Ala Leu Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu
             180                 185                 190        
 Asn Gly Asn Tyr Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro
         195                 200                 205            
 Leu Ser Leu Phe Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu
     210                 215                 220                
 Ser Leu Leu Cys Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys
 225                 230                 235                 240
 Phe Gln Val Pro Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr
                 245                 250                 255    
 Ile Asn Thr Thr Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser
             260                 265                 270        
 His Asn Val Thr Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe
         275                 280                 285            
 Asn Ser Gln Thr Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val
     290                 295                 300                
 Cys His Pro Ala Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser
 305                 310                 315                 320
 Arg Arg Arg Met Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe
                 325                 330                 335    
 Leu Met Tyr Leu Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu
             340                 345                 350        
 His Val Glu Ser Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr
         355                 360                 365            
 Asp Ile Leu Leu Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr
     370                 375                 380                
 Leu Thr Val Pro Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His
 385                 390                 395                 400
 Leu Leu Cys Ala Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile
                 405                 410                 415    
 Thr Val Ser Ile Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro
             420                 425                 430        
 Thr Ile Arg Asp Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met
         435                 440                 445            
 Leu Ile Phe Ile Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys
     450                 455                 460                
 Glu Pro Met Lys Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu
 465                 470                 475                 480
 Ser Gly Val Leu Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp
                 485                 490                 495    
 Trp Val His Asn Ala Pro Gly Gly Gly His
             500                 505    



      <210> 710
      <211> 414
      <212> PRT
      <213> Homo sapiens


      <400> 710
 Met Gly Gly Asn His Ser His Lys Pro Pro Val Phe Asp Glu Asn Glu
   1               5                  10                  15    
 Glu Val Asn Phe Asp His Phe Gln Ile Leu Arg Ala Ile Gly Lys Gly
              20                  25                  30        
 Ser Phe Gly Lys Val Cys Ile Val Gln Lys Arg Asp Thr Lys Lys Met
          35                  40                  45            
 Tyr Ala Met Lys Tyr Met Asn Lys Gln Lys Cys Ile Glu Arg Asp Glu
      50                  55                  60                
 Val Arg Asn Val Phe Arg Glu Leu Gln Ile Met Gln Gly Leu Glu His
  65                  70                  75                  80
 Pro Phe Leu Val Asn Leu Trp Tyr Ser Phe Gln Asp Glu Glu Asp Met
                  85                  90                  95    
 Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp Leu Arg Tyr His Leu
             100                 105                 110        
 Gln Gln Asn Val His Phe Thr Glu Gly Thr Val Lys Leu Tyr Ile Cys
         115                 120                 125            
 Glu Leu Ala Leu Ala Leu Glu Tyr Leu Gln Arg Tyr His Ile Ile His
     130                 135                 140                
 Arg Asp Ile Lys Pro Asp Asn Ile Leu Leu Asp Glu His Gly His Val
 145                 150                 155                 160
 His Ile Thr Asp Phe Asn Ile Ala Thr Val Val Lys Gly Ala Glu Arg
                 165                 170                 175    
 Ala Ser Ser Met Ala Gly Thr Lys Pro Tyr Met Ala Pro Glu Val Phe
             180                 185                 190        
 Gln Val Tyr Met Asp Arg Gly Pro Gly Tyr Ser Tyr Pro Val Asp Trp
         195                 200                 205            
 Trp Ser Leu Gly Ile Thr Ala Tyr Glu Leu Leu Arg Gly Trp Arg Pro
     210                 215                 220                
 Tyr Glu Ile His Ser Val Thr Pro Ile Asp Glu Ile Leu Asn Met Phe
 225                 230                 235                 240
 Lys Val Glu Arg Val His Tyr Ser Ser Thr Trp Cys Lys Gly Met Val
                 245                 250                 255    
 Ala Leu Leu Arg Lys Leu Leu Thr Lys Asp Pro Glu Ser Arg Val Ser
             260                 265                 270        
 Ser Leu His Asp Ile Gln Ser Val Pro Tyr Leu Ala Asp Met Asn Trp
         275                 280                 285            
 Asp Ala Val Phe Lys Lys Ala Leu Met Pro Gly Phe Val Pro Asn Lys
     290                 295                 300                
 Gly Arg Leu Asn Cys Asp Pro Thr Phe Glu Leu Glu Glu Met Ile Leu
 305                 310                 315                 320
 Glu Ser Lys Pro Leu His Lys Lys Lys Lys Arg Leu Ala Lys Asn Arg
                 325                 330                 335    
 Ser Arg Asp Gly Thr Lys Asp Ser Cys Pro Leu Asn Gly His Leu Gln
             340                 345                 350        
 His Cys Leu Glu Thr Val Arg Glu Glu Phe Ile Ile Phe Asn Arg Glu
         355                 360                 365            
 Lys Leu Arg Arg Gln Gln Gly Gln Gly Ser Gln Leu Leu Asp Thr Asp
     370                 375                 380                
 Ser Arg Gly Gly Gly Gln Ala Gln Ser Lys Leu Gln Asp Gly Cys Asn
 385                 390                 395                 400
 Asn Asn Leu Leu Thr His Thr Cys Thr Arg Gly Cys Ser Ser
                 405                 410                



      <210> 711
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 711
 Met Asn Lys Val Asp Gln Lys Phe Gln Gly Ser Val Ser Phe Lys Asp
   1               5                  10                  15    
 Val Thr Val Gly Phe Thr Gln Glu Glu Trp Gln His Leu Asp Pro Ser
              20                  25                  30        
 Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu
          35                  40                  45            
 Val Ser Val Gly Tyr Cys Ala His Lys Pro Glu Val Ile Phe Arg Leu
      50                  55                  60                
 Glu Gln Gly Glu Glu Pro Trp Arg Leu Glu Glu Glu Phe Pro Ser Gln
  65                  70                  75                  80
 Ser Phe Pro Gly Ser Ser Trp Leu Trp Trp Phe Pro Arg Leu Ser Leu
                  85                  90                  95    
 Phe Trp Met Thr Leu Thr Val Trp Arg Asn Pro Gly Glu Lys Ser Gly
             100                 105                 110        
 Gln Leu Ile Thr
         115    



      <210> 712
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 712
 Met Lys His Val Asn Glu Arg Phe Gln Asp Glu Lys Asn Lys Glu Val
   1               5                  10                  15    
 Val Leu Met Cys Ile Gly Val Thr Ser Gly Val Gly Arg Leu Leu Phe
              20                  25                  30        
 Gly Arg Ile Ala Asp Tyr Val Pro Gly Val Lys Lys Val Tyr Leu Gln
          35                  40                  45            
 Val Leu Ser Phe Phe Phe Ile Gly Leu Met Ser Met Met Ile Pro Leu
      50                  55                  60                
 Cys Ser Ile Phe Gly Ala Leu Ile Ala Val Cys Leu Ile Met Gly Leu
  65                  70                  75                  80
 Phe Asp Gly Cys Phe Ile Ser Ile Met Ala Pro Ile Ala Phe Glu Leu
                  85                  90                  95    
 Val Gly Ala Gln Asp Val Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe
             100                 105                 110        
 Met Ser Ile Pro Met Thr Val Gly Pro Pro Ile Ala Gly Leu Leu Arg
         115                 120                 125            
 Asp Lys Leu Gly Ser Tyr Asp Val Ala Phe Tyr Leu Ala Gly Val Pro
     130                 135                 140                
 Pro Leu Ile Gly Gly Ala Val Leu Cys Phe Ile Pro Trp Ile His Ser
 145                 150                 155                 160
 Lys Lys Gln Arg Glu Ile Ser Lys Thr Thr Gly Lys Glu Lys Met Glu
                 165                 170                 175    
 Lys Met Leu Glu Asn Gln Asn Ser Leu Leu Ser Ser Ser Ser Gly Met
             180                 185                 190        
 Phe Lys Lys Glu Ser Asp Ser Ile Ile
         195                 200    



      <210> 713
      <211> 467
      <212> PRT
      <213> Homo sapiens


      <400> 713
 Met Arg Thr Tyr Val Cys His Ile Cys Ser Ile Ala Phe Thr Ser Leu
   1               5                  10                  15    
 Asp Met Phe Arg Ser His Met Gln Gly Ser Glu His Gln Ile Lys Glu
              20                  25                  30        
 Ser Ile Val Ile Asn Leu Val Lys Asn Ser Arg Lys Thr Gln Asp Ser
          35                  40                  45            
 Tyr Gln Asn Glu Cys Ala Asp Tyr Ile Asn Val Gln Lys Ala Arg Gly
      50                  55                  60                
 Leu Glu Ala Lys Thr Cys Phe Arg Lys Met Glu Glu Ser Ser Leu Glu
  65                  70                  75                  80
 Thr Arg Arg Tyr Arg Glu Val Val Asp Ser Arg Pro Arg His Arg Met
                  85                  90                  95    
 Phe Glu Gln Arg Leu Pro Phe Glu Thr Phe Arg Thr Tyr Ala Ala Pro
             100                 105                 110        
 Tyr Asn Ile Ser Gln Ala Met Glu Lys Gln Leu Pro His Ser Lys Lys
         115                 120                 125            
 Thr Tyr Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val Gln
     130                 135                 140                
 Lys Ala Arg Gly Leu Asp Pro Lys Thr Cys Phe Arg Lys Met Arg Glu
 145                 150                 155                 160
 Asn Ser Val Asp Thr His Gly Tyr Arg Glu Met Val Asp Ser Gly Pro
                 165                 170                 175    
 Arg Ser Arg Met Cys Glu Gln Arg Phe Ser His Glu Ala Ser Gln Thr
             180                 185                 190        
 Tyr Gln Arg Pro Tyr His Ile Ser Pro Val Glu Ser Gln Leu Pro Gln
         195                 200                 205            
 Trp Leu Pro Thr His Ser Lys Arg Thr Tyr Asp Ser Phe Gln Asp Glu
     210                 215                 220                
 Leu Glu Asp Tyr Ile Lys Val Gln Lys Ala Arg Gly Leu Glu Pro Lys
 225                 230                 235                 240
 Thr Cys Phe Arg Lys Ile Gly Asp Ser Ser Val Glu Thr His Arg Asn
                 245                 250                 255    
 Arg Glu Met Val Asp Val Arg Pro Arg His Arg Met Leu Glu Gln Lys
             260                 265                 270        
 Leu Pro Cys Glu Thr Phe Gln Thr Tyr Ser Gly Pro Tyr Ser Ile Ser
         275                 280                 285            
 Gln Val Val Glu Asn Gln Leu Pro His Cys Leu Pro Ala His Asp Ser
     290                 295                 300                
 Lys Gln Arg Leu Asp Ser Ile Ser Tyr Cys Gln Leu Thr Arg Asp Cys
 305                 310                 315                 320
 Phe Pro Glu Lys Pro Val Pro Leu Ser Leu Asn Gln Gln Glu Asn Asn
                 325                 330                 335    
 Ser Gly Ser Tyr Ser Val Glu Ser Glu Val Tyr Lys His Leu Ser Ser
             340                 345                 350        
 Glu Asn Asn Thr Ala Asp His Gln Ala Gly His Lys Arg Lys His Gln
         355                 360                 365            
 Lys Arg Lys Arg His Leu Glu Glu Gly Lys Glu Arg Pro Glu Lys Glu
     370                 375                 380                
 Gln Ser Lys His Lys Arg Lys Lys Ser Tyr Glu Asp Thr Asp Leu Asp
 385                 390                 395                 400
 Lys Asp Lys Ser Ile Arg Gln Arg Lys Arg Glu Glu Asp Arg Val Lys
                 405                 410                 415    
 Val Ser Ser Gly Lys Leu Lys His Arg Lys Lys Lys Lys Ser His Asp
             420                 425                 430        
 Val Pro Ser Glu Lys Glu Glu Arg Lys His Arg Lys Glu Lys Lys Lys
         435                 440                 445            
 Ser Val Glu Glu Arg Thr Glu Glu Glu Met Leu Trp Asp Glu Ser Ile
     450                 455                 460                
 Leu Gly Phe
 465        



      <210> 714
      <211> 594
      <212> PRT
      <213> Homo sapiens


      <400> 714
 Met Glu Met Cys Asp Gln Arg His Asn Ile Thr Met Cys Pro Leu Cys
   1               5                  10                  15    
 Asp Lys Thr Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala Thr Ala
              20                  25                  30        
 Arg Ala Ser His Leu Phe Asp Asn Pro Ala Thr Val Phe Phe Ser Val
          35                  40                  45            
 Phe Met Ala Leu Trp Ala Ala Thr Phe Met Glu His Trp Lys Arg Lys
      50                  55                  60                
 Gln Met Arg Leu Asn Tyr Arg Trp Asp Leu Thr Gly Phe Glu Glu Glu
  65                  70                  75                  80
 Glu Glu Ala Val Lys Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val
                  85                  90                  95    
 Leu Glu Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Thr Asp Lys
             100                 105                 110        
 Val Lys Leu Thr Trp Arg Asp Arg Phe Pro Ala Tyr Leu Thr Asn Leu
         115                 120                 125            
 Val Ser Ile Ile Phe Met Ile Ala Val Thr Phe Ala Ile Val Leu Gly
     130                 135                 140                
 Val Ile Ile Tyr Arg Ile Ser Met Ala Ala Ala Leu Ala Met Asn Ser
 145                 150                 155                 160
 Ser Pro Ser Val Arg Ser Asn Ile Arg Val Thr Val Thr Ala Thr Ala
                 165                 170                 175    
 Val Ile Ile Asn Leu Val Val Ile Ile Leu Leu Asp Glu Val Tyr Gly
             180                 185                 190        
 Cys Ile Ala Arg Trp Leu Thr Lys Ile Glu Val Pro Lys Thr Glu Lys
         195                 200                 205            
 Ser Phe Glu Glu Arg Leu Ile Phe Lys Ala Phe Leu Leu Lys Phe Val
     210                 215                 220                
 Asn Ser Tyr Thr Pro Ile Phe Tyr Val Ala Phe Phe Lys Gly Arg Phe
 225                 230                 235                 240
 Val Gly Arg Pro Gly Asp Tyr Val Tyr Ile Phe Arg Ser Phe Arg Met
                 245                 250                 255    
 Glu Glu Cys Ala Pro Gly Gly Cys Leu Met Glu Leu Cys Ile Gln Leu
             260                 265                 270        
 Ser Ile Ile Met Leu Gly Lys Gln Leu Ile Gln Asn Asn Leu Phe Glu
         275                 280                 285            
 Ile Gly Ile Pro Lys Met Lys Lys Leu Ile Arg Tyr Leu Lys Leu Lys
     290                 295                 300                
 Gln Gln Ser Pro Pro Asp His Glu Glu Cys Val Lys Arg Lys Gln Arg
 305                 310                 315                 320
 Tyr Glu Val Asp Tyr Asn Leu Glu Pro Phe Ala Gly Leu Thr Pro Glu
                 325                 330                 335    
 Tyr Met Glu Met Ile Ile Gln Phe Gly Phe Val Thr Leu Phe Val Ala
             340                 345                 350        
 Ser Phe Pro Leu Ala Pro Leu Phe Ala Leu Leu Asn Asn Ile Ile Glu
         355                 360                 365            
 Ile Arg Leu Asp Ala Lys Lys Phe Val Thr Glu Leu Arg Arg Pro Val
     370                 375                 380                
 Ala Val Arg Ala Lys Asp Ile Gly Ile Trp Tyr Asn Ile Leu Arg Gly
 385                 390                 395                 400
 Ile Gly Lys Leu Ala Val Ile Ile Asn Ala Phe Val Ile Ser Phe Thr
                 405                 410                 415    
 Ser Asp Phe Ile Pro Arg Leu Val Tyr Leu Tyr Met Tyr Ser Lys Asn
             420                 425                 430        
 Gly Thr Met His Gly Phe Val Asn His Thr Leu Ser Ser Phe Asn Val
         435                 440                 445            
 Ser Asp Phe Gln Asn Gly Thr Ala Pro Asn Asp Pro Leu Asp Leu Gly
     450                 455                 460                
 Tyr Glu Val Gln Ile Cys Arg Tyr Lys Asp Tyr Arg Glu Pro Pro Trp
 465                 470                 475                 480
 Ser Glu Asn Lys Tyr Asp Ile Ser Lys Asp Phe Trp Ala Val Leu Ala
                 485                 490                 495    
 Ala Arg Leu Ala Phe Val Ile Val Phe Gln Asn Leu Val Met Phe Met
             500                 505                 510        
 Ser Asp Phe Val Asp Trp Val Ile Pro Asp Ile Pro Lys Asp Ile Ser
         515                 520                 525            
 Gln Gln Ile His Lys Glu Lys Val Leu Met Val Glu Leu Phe Met Arg
     530                 535                 540                
 Glu Glu Gln Asp Lys Gln Gln Leu Leu Glu Thr Trp Met Glu Lys Glu
 545                 550                 555                 560
 Arg Gln Lys Asp Glu Pro Pro Cys Asn His His Asn Thr Lys Ala Cys
                 565                 570                 575    
 Pro Asp Ser Leu Gly Ser Pro Ala Pro Ser His Ala Tyr His Gly Gly
             580                 585                 590        
 Val Leu
        



      <210> 715
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 715
 Met Val Gly Ala Leu Cys Gly Cys Trp Phe Arg Leu Gly Gly Ala Arg
   1               5                  10                  15    
 Pro Leu Ile Pro Leu Gly Pro Thr Val Val Gln Thr Ser Met Ser Arg
              20                  25                  30        
 Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu Leu
          35                  40                  45            
 Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp Gly
      50                  55                  60                
 Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser Pro
  65                  70                  75                  80
 Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala His Arg Val Glu
                  85                  90                  95    
 Val Val Leu Leu His Gly Lys Ala Phe Asn Ser His Thr Trp Glu Gln
             100                 105                 110        
 Leu Gly Thr Leu Gln Leu Leu Ser Gln Arg Gly Tyr Arg Ala Val Ala
         115                 120                 125            
 Leu Asp Leu Pro Gly Phe Gly Asn Ser Ala Pro Ser Lys Glu Ala Ser
     130                 135                 140                
 Thr Glu Ala Gly Arg Ala Ala Leu Leu Glu Arg Ala Leu Arg Asp Leu
 145                 150                 155                 160
 Glu Val Gln Asn Ala Val Leu Val Ser Pro Ser Leu Ser Gly His Tyr
                 165                 170                 175    
 Ala Leu Pro Phe Leu Met Arg Gly His His Gln Leu His Gly Phe Val
             180                 185                 190        
 Pro Ile Ala Pro Thr Ser Thr Gln Asn Tyr Thr Gln Glu Gln Phe Trp
         195                 200                 205            
 Ala Val Lys Thr Pro Thr Leu Ile Leu Tyr Gly Glu Leu Asp His Ile
     210                 215                 220                
 Leu Ala Arg Glu Ser Leu Arg Gln Leu Arg His Leu Pro Asn His Ser
 225                 230                 235                 240
 Val Val Lys Leu Arg Asn Ala Gly His Ala Cys Tyr Leu His Lys Pro
                 245                 250                 255    
 Gln Asp Phe His Leu Val Leu Leu Ala Phe Leu Asp His Leu Pro
             260                 265                 270    



      <210> 716
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 716
 Met Pro Val Lys Lys Lys Arg Lys Ser Pro Gly Val Ala Ala Ala Val
   1               5                  10                  15    
 Ala Glu Asp Gly Gly Leu Lys Lys Cys Lys Ile Ser Ser Tyr Cys Arg
              20                  25                  30        
 Ser Gln Pro Pro Ala Arg Leu Ile Ser Gly Glu Glu His Phe Ser Ser
          35                  40                  45            
 Lys Lys Cys Leu Ala Trp Phe Tyr Glu Tyr Ala Gly Pro Asp Glu Val
      50                  55                  60                
 Val Gly Pro Glu Gly Met Glu Lys Phe Cys Glu Asp Ile Gly Val Glu
  65                  70                  75                  80
 Pro Glu Asn Ile Ile Met Leu Val Leu Ala Trp Lys Leu Glu Ala Glu
                  85                  90                  95    
 Ser Met Gly Phe Phe Thr Lys Glu Glu Trp Leu Lys Gly Met Thr Ser
             100                 105                 110        
 Leu Gln Cys Asp Cys Thr Glu Lys Leu Gln Asn Lys Phe Asp Phe Leu
         115                 120                 125            
 Arg Ser Gln Leu Asn Asp Ile Ser Ser Phe Lys Asn Ile Tyr Arg Tyr
     130                 135                 140                
 Ala Phe Asp Phe Ala Arg Asp Lys Asp Gln Arg Ser Leu Asp Ile Asp
 145                 150                 155                 160
 Thr Ala Lys Ser Met Leu Ala Leu Leu Leu Gly Arg Thr Trp Pro Leu
                 165                 170                 175    
 Phe Ser Val Phe Tyr Gln Tyr Leu Glu Gln Ser Lys Tyr Arg Val Met
             180                 185                 190        
 Asn Lys Asp Gln Trp Tyr Asn Val Leu Glu Phe Ser Arg Thr Val His
         195                 200                 205            
 Ala Asp Leu Ser Asn Tyr Asp Glu Asp Gly Ala Trp Pro Val Leu Leu
     210                 215                 220                
 Asp Glu Phe Val Glu Trp Gln Lys Val Arg Gln Thr Ser
 225                 230                 235        



      <210> 717
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 717
 Met Ser Val Asp Ser Ala Arg Ala Ala Leu Leu Ser Thr Gln Thr Leu
   1               5                  10                  15    
 Pro Ala Pro Ser Pro Thr Ser Pro Pro Gly Gly Ile Leu Lys Thr Ser
              20                  25                  30        
 Lys Glu Ala Asp Ala Glu Ser Leu Gln Ala Ala Trp Tyr Pro Arg Thr
          35                  40                  45            
 Ser Leu Pro Thr Pro Leu Arg Ala His Asp Ile Leu His Leu Val Glu
      50                  55                  60                
 Leu Ala Ala Gln Tyr Arg Gln Gln Ala Arg His Pro Leu Ile Leu Pro
  65                  70                  75                  80
 Gln Glu Leu Pro Cys Asp Leu Val Cys Gln Arg Leu Val Ala Thr Phe
                  85                  90                  95    
 Thr Ser Ala Gln Thr Val Trp Val Leu Val Gly Thr Val Gly Met Pro
             100                 105                 110        
 His Leu Pro Val Thr Ala Cys Gly Leu Asp Pro Val Glu Gln Arg Gly
         115                 120                 125            
 Gly Met Lys Met Ala Val Leu Arg Leu Leu Gln Glu Cys Leu Thr Leu
     130                 135                 140                
 His His Leu Val Val Glu Ile Lys Gly Leu Leu Gly Leu Gln His Leu
 145                 150                 155                 160
 Gly Arg Asp His Ser Asp Gly Ile Cys Leu Asn Val Leu Val Thr Val
                 165                 170                 175    
 Ala Phe Arg Ser Pro Gly Ile Gln Asp Glu Pro Pro Lys Val Arg Gly
             180                 185                 190        
 Glu Asn Phe Ser Trp Trp Lys Val Met Glu Glu Asp Leu Gln Ser Gln
         195                 200                 205            
 Leu Leu Gln Arg Leu Gln Gly Ser Ser Val Val Pro Val Asn Arg
     210                 215                 220            



      <210> 718
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 718
 Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg
   1               5                  10                  15    
 Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala
              20                  25                  30        
 Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys
          35                  40                  45            
 Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala
      50                  55                  60                
 Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro Pro
  65                  70                  75                  80
 Thr Leu Ser Ala Ser Phe Arg Thr Met Ala Glu Phe Met Asp Tyr Thr
                  85                  90                  95    
 Ser Ser Gln Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly
             100                 105                 110        
 Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met
         115                 120                 125            
 Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp Arg Lys Lys Thr Ser
     130                 135                 140                
 Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu His Ala Pro Glu Ala
 145                 150                 155                 160
 Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu Tyr Ile Glu Val Tyr
                 165                 170                 175    
 Pro Gly Thr Tyr Ser Val Thr Val Gly Ser Asn Asp Leu Thr Lys Lys
             180                 185                 190        
 Thr His Val Val Ala Val Asp Ser Gly Gln Ser Val Asp Leu Val Phe
         195                 200                 205            
 Pro Val
     210



      <210> 719
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 719
 Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg
   1               5                  10                  15    
 Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala
              20                  25                  30        
 Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys
          35                  40                  45            
 Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala
      50                  55                  60                
 Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val
  65                  70                  75                  80
 Pro Glu Glu Gly Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu
                  85                  90                  95    
 Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp
             100                 105                 110        
 Arg Lys Lys Thr Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu
         115                 120                 125            
 His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu
     130                 135                 140                
 Tyr Ile Glu Val Tyr Pro Gly Thr Tyr Ser Val Thr Val Gly Ser Asn
 145                 150                 155                 160
 Asp Leu Thr Lys Lys Thr His Val Val Ala Val Asp Ser Gly Gln Ser
                 165                 170                 175    
 Val Asp Leu Val Phe Pro Val
             180            



      <210> 720
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 720
 Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg
   1               5                  10                  15    
 Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala
              20                  25                  30        
 Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys
          35                  40                  45            
 Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala
      50                  55                  60                
 Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val
  65                  70                  75                  80
 Pro Glu Glu Gly Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu
                  85                  90                  95    
 Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Ala Glu Asn
             100                 105                 110        
 Ile Ser Lys Asp Leu Tyr Ile Glu Val Tyr Pro Gly Thr Tyr Ser Val
         115                 120                 125            
 Thr Val Gly Ser Asn Asp Leu Thr Lys Lys Thr His Val Val Ala Val
     130                 135                 140                
 Asp Ser Gly Gln Ser Val Asp Leu Val Phe Pro Val
 145                 150                 155    



      <210> 721
      <211> 392
      <212> PRT
      <213> Homo sapiens


      <400> 721
 Met Ser Arg Glu Pro Thr Pro Pro Leu Pro Gly Asp Met Ser Thr Gly
   1               5                  10                  15    
 Pro Ile Ala Glu Ser Trp Cys Tyr Thr Gln Val Lys Val Val Lys Phe
              20                  25                  30        
 Ser Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met
          35                  40                  45            
 Gly Glu Val Leu Lys Ser Ser Thr Phe Ser Ser Gly Pro Ser Asp Lys
      50                  55                  60                
 Met Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Asp Glu Ser
  65                  70                  75                  80
 Lys Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser
                  85                  90                  95    
 Glu Val Arg Ala Lys Phe Lys Phe Ser Leu Leu Asn Ala Lys Arg Glu
             100                 105                 110        
 Glu Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly
         115                 120                 125            
 Lys Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp
     130                 135                 140                
 Glu Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu
 145                 150                 155                 160
 Val Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly His Thr Asn Thr
                 165                 170                 175    
 Asn Thr Leu Lys Val Pro Glu Cys Arg Leu Ala Glu Asp Leu Gly Asn
             180                 185                 190        
 Leu Trp Glu Asn Thr Arg Phe Thr Asp Cys Ser Phe Phe Val Arg Gly
         195                 200                 205            
 Gln Glu Phe Lys Ala His Lys Ser Val Leu Ala Ala Arg Ser Pro Val
     210                 215                 220                
 Phe Asn Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg
 225                 230                 235                 240
 Val Glu Ile Asn Asp Leu Asp Pro Glu Val Phe Lys Glu Met Met Arg
                 245                 250                 255    
 Phe Ile Tyr Thr Gly Arg Ala Pro Asn Leu Asp Lys Met Ala Asp Asn
             260                 265                 270        
 Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met
         275                 280                 285            
 Cys Glu Glu Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Val Ala Asp
     290                 295                 300                
 Thr Leu Val Leu Ala Asp Leu His Ser Ala Glu Gln Leu Lys Ala Gln
 305                 310                 315                 320
 Ala Ile Asp Phe Ile Asn Arg Cys Ser Val Leu Arg Gln Leu Gly Cys
                 325                 330                 335    
 Lys Asp Gly Lys Asn Trp Asn Ser Asn Gln Ala Thr Asp Ile Met Glu
             340                 345                 350        
 Thr Ser Gly Trp Lys Ser Met Ile Gln Ser His Pro His Leu Val Ala
         355                 360                 365            
 Glu Ala Phe Arg Ala Leu Ala Ser Ala Gln Cys Pro Gln Phe Gly Ile
     370                 375                 380                
 Pro Arg Lys Arg Leu Lys Gln Ser
 385                 390        



      <210> 722
      <211> 1307
      <212> PRT
      <213> Homo sapiens


      <400> 722
 Met Glu Asp Met Arg Gly Gln Gln Glu Arg Glu Gly Pro Gly Arg Asp
   1               5                  10                  15    
 His Ala Pro Ser Ile Pro Thr Ser Pro Phe Gly Asp Ser Leu Glu Ser
              20                  25                  30        
 Ser Thr Glu Leu Arg Arg His Leu Gln Phe Val Glu Glu Glu Ala Glu
          35                  40                  45            
 Leu Leu Arg Arg Ser Ile Ser Glu Ile Glu Asp His Asn Arg Gln Leu
      50                  55                  60                
 Thr His Glu Leu Ser Lys Phe Lys Phe Glu Pro Pro Arg Glu Pro Gly
  65                  70                  75                  80
 Trp Leu Gly Glu Gly Ala Ser Pro Gly Ala Gly Gly Gly Ala Pro Leu
                  85                  90                  95    
 Gln Glu Glu Leu Lys Ser Ala Arg Leu Gln Ile Ser Glu Leu Ser Gly
             100                 105                 110        
 Lys Val Leu Lys Leu Gln His Glu Asn His Ala Leu Leu Ser Asn Ile
         115                 120                 125            
 Gln Arg Cys Asp Leu Ala Ala His Leu Gly Leu Arg Ala Pro Ser Pro
     130                 135                 140                
 Arg Asp Ser Asp Ala Glu Ser Asp Ala Gly Lys Lys Glu Ser Asp Gly
 145                 150                 155                 160
 Glu Glu Ser Arg Leu Pro Gln Pro Lys Arg Glu Gly Pro Val Gly Gly
                 165                 170                 175    
 Glu Ser Asp Ser Glu Glu Met Phe Glu Lys Thr Ser Gly Phe Gly Ser
             180                 185                 190        
 Gly Lys Pro Ser Glu Ala Ser Glu Pro Cys Pro Thr Glu Leu Leu Lys
         195                 200                 205            
 Ala Arg Glu Asp Ser Glu Tyr Leu Val Thr Leu Lys His Glu Ala Gln
     210                 215                 220                
 Arg Leu Glu Arg Thr Val Glu Arg Leu Ile Thr Asp Thr Asp Ser Phe
 225                 230                 235                 240
 Leu His Asp Ala Gly Leu Arg Gly Gly Ala Pro Leu Pro Gly Pro Gly
                 245                 250                 255    
 Leu Gln Gly Glu Glu Glu Gln Gly Glu Gly Asp Gln Gln Glu Pro Gln
             260                 265                 270        
 Leu Leu Gly Thr Ile Asn Ala Lys Met Lys Ala Phe Lys Lys Glu Leu
         275                 280                 285            
 Gln Ala Phe Leu Glu Gln Val Asn Arg Ile Gly Asp Gly Leu Ser Pro
     290                 295                 300                
 Leu Pro His Leu Thr Glu Ser Ser Ser Phe Leu Ser Thr Val Thr Ser
 305                 310                 315                 320
 Val Ser Arg Asp Ser Pro Ile Gly Asn Leu Gly Lys Glu Leu Gly Pro
                 325                 330                 335    
 Asp Leu Gln Ser Arg Leu Lys Glu Gln Leu Glu Trp Gln Leu Gly Pro
             340                 345                 350        
 Ala Arg Gly Asp Glu Arg Glu Ser Leu Arg Leu Arg Ala Ala Arg Glu
         355                 360                 365            
 Leu His Arg Arg Ala Asp Gly Asp Thr Gly Ser His Gly Leu Gly Gly
     370                 375                 380                
 Gln Thr Cys Phe Ser Leu Glu Met Glu Glu Glu His Leu Tyr Ala Leu
 385                 390                 395                 400
 Arg Trp Lys Glu Leu Glu Met His Ser Leu Ala Leu Gln Asn Thr Leu
                 405                 410                 415    
 His Glu Arg Thr Trp Ser Asp Glu Lys Asn Leu Met Gln Gln Glu Leu
             420                 425                 430        
 Arg Ser Leu Lys Gln Asn Ile Phe Leu Phe Tyr Val Lys Leu Arg Trp
         435                 440                 445            
 Leu Leu Lys His Trp Arg Gln Gly Lys Gln Met Glu Glu Glu Gly Glu
     450                 455                 460                
 Glu Phe Thr Glu Gly Glu His Pro Glu Thr Leu Ser Arg Leu Gly Glu
 465                 470                 475                 480
 Leu Gly Val Gln Gly Gly His Gln Ala Asp Gly Pro Asp His Asp Ser
                 485                 490                 495    
 Asp Arg Gly Cys Gly Phe Pro Val Gly Glu His Ser Pro His Ser Arg
             500                 505                 510        
 Val Gln Ile Gly Asp His Ser Leu Arg Leu Gln Thr Ala Asp Arg Gly
         515                 520                 525            
 Gln Pro His Lys Gln Val Val Glu Asn Gln Gln Leu Phe Ser Ala Phe
     530                 535                 540                
 Lys Ala Leu Leu Glu Asp Phe Arg Ala Glu Leu Arg Glu Asp Glu Arg
 545                 550                 555                 560
 Ala Arg Leu Arg Leu Gln Gln Gln Tyr Ala Ser Asp Lys Ala Ala Trp
                 565                 570                 575    
 Asp Val Glu Trp Ala Val Leu Lys Cys Arg Leu Glu Gln Leu Glu Glu
             580                 585                 590        
 Lys Thr Glu Asn Lys Leu Gly Glu Leu Gly Ser Ser Ala Glu Ser Lys
         595                 600                 605            
 Gly Ala Leu Lys Lys Glu Arg Glu Val His Gln Lys Leu Leu Ala Asp
     610                 615                 620                
 Ser His Ser Leu Val Met Asp Leu Arg Trp Gln Ile His His Ser Glu
 625                 630                 635                 640
 Lys Asn Trp Asn Arg Glu Lys Val Glu Leu Leu Asp Arg Leu Asp Arg
                 645                 650                 655    
 Asp Arg Gln Glu Trp Glu Arg Gln Lys Lys Glu Phe Leu Trp Arg Ile
             660                 665                 670        
 Glu Gln Leu Gln Lys Glu Asn Ser Pro Arg Arg Gly Gly Ser Phe Leu
         675                 680                 685            
 Cys Asp Gln Lys Asp Gly Asn Val Arg Pro Phe Pro His Gln Gly Ser
     690                 695                 700                
 Leu Arg Met Pro Arg Pro Val Ala Met Trp Pro Cys Ala Asp Ala Asp
 705                 710                 715                 720
 Ser Ile Pro Phe Glu Asp Arg Pro Leu Ser Lys Leu Lys Glu Ser Asp
                 725                 730                 735    
 Arg Cys Ser Ala Ser Glu Asn Leu Tyr Leu Asp Ala Leu Ser Leu Asp
             740                 745                 750        
 Asp Glu Pro Glu Glu Pro Pro Ala His Arg Pro Glu Arg Glu Phe Arg
         755                 760                 765            
 Asn Arg Leu Pro Glu Glu Glu Glu Asn His Lys Gly Asn Leu Gln Arg
     770                 775                 780                
 Ala Val Ser Val Ser Ser Met Ser Glu Phe Gln Arg Leu Met Asp Ile
 785                 790                 795                 800
 Ser Pro Phe Leu Pro Glu Lys Gly Leu Pro Ser Thr Ser Ser Lys Glu
                 805                 810                 815    
 Asp Val Thr Pro Pro Leu Ser Pro Asp Asp Leu Lys Tyr Ile Glu Glu
             820                 825                 830        
 Phe Asn Lys Ser Trp Asp Tyr Thr Pro Asn Arg Gly His Asn Gly Gly
         835                 840                 845            
 Gly Pro Asp Leu Trp Ala Asp Arg Thr Glu Val Gly Arg Ala Gly His
     850                 855                 860                
 Glu Asp Ser Thr Glu Pro Phe Pro Asp Ser Ser Trp Tyr Leu Thr Thr
 865                 870                 875                 880
 Ser Val Thr Met Thr Thr Asp Thr Met Thr Ser Pro Glu His Cys Gln
                 885                 890                 895    
 Lys Gln Pro Leu Arg Ser His Val Leu Thr Glu Gln Ser Gly Leu Arg
             900                 905                 910        
 Val Leu His Ser Pro Pro Ala Val Arg Arg Val Asp Ser Ile Thr Ala
         915                 920                 925            
 Ala Gly Gly Glu Gly Pro Phe Pro Thr Ser Arg Ala Arg Gly Ser Pro
     930                 935                 940                
 Gly Asp Thr Lys Gly Gly Pro Pro Glu Pro Met Leu Ser Arg Trp Pro
 945                 950                 955                 960
 Cys Thr Ser Pro Arg His Ser Arg Asp Tyr Val Glu Gly Ala Arg Arg
                 965                 970                 975    
 Pro Leu Asp Ser Pro Leu Cys Thr Ser Leu Gly Phe Ala Ser Pro Leu
             980                 985                 990        
 His Ser Leu Glu Met Ser Lys Asn Leu Ser Asp Asp Met Lys Glu Val
         995                1000                1005            
 Ala Phe Ser Val Arg Asn Ala Ile Cys Ser Gly Pro Gly Glu Leu Gln
    1010                1015                1020                
 Val Lys Asp Met Ala Cys Gln Thr Asn Gly Ser Arg Thr Met Gly Thr
1025                1030                1035                1040
 Gln Thr Val Gln Thr Ile Ser Val Gly Leu Gln Thr Glu Ala Leu Arg
                1045                1050                1055    
 Gly Ser Gly Val Thr Ser Ser Pro His Lys Cys Leu Thr Pro Lys Ala
            1060                1065                1070        
 Gly Gly Gly Ala Thr Pro Val Ser Ser Pro Ser Arg Ser Leu Arg Ser
        1075                1080                1085            
 Arg Gln Val Ala Pro Ala Ile Glu Lys Val Gln Ala Lys Phe Glu Arg
    1090                1095                1100                
 Thr Cys Cys Ser Pro Lys Tyr Gly Ser Pro Lys Leu Gln Arg Lys Pro
1105                1110                1115                1120
 Leu Pro Lys Ala Asp Gln Pro Asn Asn Arg Thr Ser Pro Gly Met Ala
                1125                1130                1135    
 Gln Lys Gly Tyr Ser Glu Ser Ala Trp Ala Arg Ser Thr Thr Thr Arg
            1140                1145                1150        
 Glu Ser Pro Val His Thr Thr Ile Asn Asp Gly Leu Ser Ser Leu Phe
        1155                1160                1165            
 Asn Ile Ile Asp His Ser Pro Val Val Gln Asp Pro Phe Gln Lys Gly
    1170                1175                1180                
 Leu Arg Ala Gly Ser Arg Ser Arg Ser Ala Glu Pro Arg Pro Glu Leu
1185                1190                1195                1200
 Gly Pro Gly Gln Glu Thr Gly Thr Asn Ser Arg Gly Arg Ser Pro Ser
                1205                1210                1215    
 Pro Ile Gly Val Gly Ser Glu Met Cys Arg Glu Glu Gly Gly Glu Gly
            1220                1225                1230        
 Thr Pro Val Lys Gln Asp Leu Ser Ala Pro Pro Gly Tyr Thr Leu Thr
        1235                1240                1245            
 Glu Asn Val Ala Arg Ile Leu Asn Lys Lys Leu Leu Glu His Ala Leu
    1250                1255                1260                
 Lys Glu Glu Arg Arg Gln Ala Ala His Gly Pro Pro Gly Leu His Ser
1265                1270                1275                1280
 Asp Ser His Ser Leu Gly Asp Thr Ala Glu Pro Gly Pro Met Glu Asn
                1285                1290                1295    
 Gln Thr Val Leu Leu Thr Ala Pro Trp Gly Leu
            1300                1305        



      <210> 723
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 723
 Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys
   1               5                  10                  15    
 Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg
              20                  25                  30        
 Ser Arg Lys Glu Ser Tyr Ser Ile Tyr Val Tyr Lys Val Leu Lys Gln
          35                  40                  45            
 Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn
      50                  55                  60                
 Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Gly Val Ala Glu
  65                  70                  75                  80
 Thr Ser Gln Gln Ala His Leu His
                  85            



      <210> 724
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 724
 Met Ser Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro Trp Gly Phe Arg
   1               5                  10                  15    
 Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Arg Ile
              20                  25                  30        
 Thr Pro Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser Gln Gly Asp Leu
          35                  40                  45            
 Val Val Ala Ile Asp Gly Val Asn Thr Asp Thr Met Thr His Leu Glu
      50                  55                  60                
 Ala Gln Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu Ser Leu Thr Leu
  65                  70                  75                  80
 Gln Lys Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr Ala Pro Pro Val
                  85                  90                  95    
 Gln Thr Pro Leu Pro Val Ile Pro His Gln Lys Val Val Val Asn Ser
             100                 105                 110        
 Pro Ala Asn Ala Asp Tyr Gln Glu Arg Phe Asn Pro Ser Ala Leu Lys
         115                 120                 125            
 Asp Ser Ala Leu Ser Thr His Lys Pro Ile Glu Val Lys Gly Leu Gly
     130                 135                 140                
 Gly Glu Ala Thr Ile Ile His Ala Gln Tyr Asn Thr Pro Ile Ser Met
 145                 150                 155                 160
 Tyr Ser Gln Asp Ala Ile Met Asp Ala Ile Ala Gly Gln Ala Gln Ala
                 165                 170                 175    
 Gln Gly Ser Asp Phe Ser Gly
             180            



      <210> 725
      <211> 283
      <212> PRT
      <213> Homo sapiens


      <400> 725
 Met Ser Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro Trp Gly Phe Arg
   1               5                  10                  15    
 Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Arg Ile
              20                  25                  30        
 Thr Pro Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser Gln Gly Asp Leu
          35                  40                  45            
 Val Val Ala Ile Asp Gly Val Asn Thr Asp Thr Met Thr His Leu Glu
      50                  55                  60                
 Ala Gln Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu Ser Leu Thr Leu
  65                  70                  75                  80
 Gln Lys Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr Ala Pro Pro Val
                  85                  90                  95    
 Gln Thr Pro Leu Pro Val Ile Pro His Gln Lys Val Val Val Asn Ser
             100                 105                 110        
 Pro Ala Asn Ala Asp Tyr Gln Glu Arg Phe Asn Pro Ser Ala Leu Lys
         115                 120                 125            
 Asp Ser Ala Leu Ser Thr His Lys Pro Ile Glu Val Lys Gly Leu Gly
     130                 135                 140                
 Gly Lys Ala Thr Ile Ile His Ala Gln Tyr Asn Thr Pro Ile Ser Met
 145                 150                 155                 160
 Tyr Ser Gln Asp Ala Ile Met Asp Ala Ile Ala Gly Gln Ala Gln Ala
                 165                 170                 175    
 Gln Gly Ser Asp Phe Ser Gly Ser Leu Pro Ile Lys Asp Leu Ala Val
             180                 185                 190        
 Asp Ser Ala Ser Pro Val Tyr Gln Ala Val Ile Lys Ser Gln Asn Lys
         195                 200                 205            
 Pro Glu Asp Glu Ala Asp Glu Trp Ala Arg Arg Ser Ser Asn Leu Gln
     210                 215                 220                
 Ser Arg Ser Phe Arg Ile Leu Ala Gln Met Thr Gly Thr Glu Phe Met
 225                 230                 235                 240
 Gln Asp Pro Asp Glu Glu Ala Leu Arg Arg Ser Arg Glu Arg Phe Glu
                 245                 250                 255    
 Thr Glu Arg Asn Ser Pro Arg Phe Ala Lys Leu Arg Asn Trp His His
             260                 265                 270        
 Gly Leu Ser Ala Gln Ile Leu Asn Val Lys Ser
         275                 280            



      <210> 726
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 726
 Met Ser Ser Asn Gly Ile Pro Glu Cys Tyr Ala Glu Glu Asp Glu Phe
   1               5                  10                  15    
 Ser Gly Leu Glu Thr Asp Thr Ala Val Pro Thr Glu Glu Ala Tyr Val
              20                  25                  30        
 Ile Tyr Asp Glu Asp Tyr Glu Phe Glu Thr Ser Arg Pro Pro Thr Thr
          35                  40                  45            
 Thr Glu Pro Ser Thr Thr Ala Thr Thr Pro Arg Val Ile Pro Glu Glu
      50                  55                  60                
 Gly Ala Ile Ser Ser Phe Pro Glu Glu Glu Phe Asp Leu Ala Gly Arg
  65                  70                  75                  80
 Lys Arg Phe Val Ala Pro Tyr Val Thr Tyr Leu Asn Lys Asp Pro Ser
                  85                  90                  95    
 Ala Pro Cys Ser Leu Thr Asp Ala Leu Asp His Phe Gln Val Asp Ser
             100                 105                 110        
 Leu Asp Glu Ile Ile Pro Asn Asp Leu Lys Lys Ser Asp Leu Pro Pro
         115                 120                 125            
 Gln His Ala Pro Arg Asn Ile Thr Val Val Ala Val Glu Gly Cys His
     130                 135                 140                
 Ser Phe Val Ile Val Asp Trp Asp Lys Ala Thr Pro Gly Asp Val Val
 145                 150                 155                 160
 Thr Gly Tyr Leu Val Tyr Ser Ala Ser Tyr Glu Asp Phe Ile Arg Asn
                 165                 170                 175    
 Lys Trp Ser Thr Gln Ala Ser Ser Val Thr His Leu Pro Ile Glu Asn
             180                 185                 190        
 Leu Lys Pro Asn Thr Arg Tyr Tyr Phe Lys Val Gln Ala Gln Asn Pro
         195                 200                 205            
 His Gly Tyr Gly Pro Ile Ser Pro Ser Val Ser Phe Val Thr Glu Ser
     210                 215                 220                
 Asp Asn Pro Leu Leu Val Val Arg Pro Pro Gly Gly Glu Pro Ile Trp
 225                 230                 235                 240
 Ile Pro Phe Ala Phe Lys His Asp Pro Ser Tyr Thr Asp Cys His Gly
                 245                 250                 255    
 Arg Gln Tyr Val Lys Arg Thr Trp Tyr Arg Lys Phe Val Gly Val Val
             260                 265                 270        
 Leu Cys Asn Ser Leu Arg Tyr Lys Ile Tyr Leu Ser Asp Asn Leu Lys
         275                 280                 285            
 Asp Thr Phe Tyr Ser Ile Gly Asp Ser Trp Gly Arg Gly Glu Asp His
     290                 295                 300                
 Cys Gln Phe Val Asp Ser His Leu Asp Gly Arg Thr Gly Pro Gln Ser
 305                 310                 315                 320
 Tyr Val Glu Ala Leu Pro Thr Ile Gln Gly Tyr Tyr Arg Gln Tyr Arg
                 325                 330                 335    
 Gln Glu Pro Val Arg Phe Gly Asn Ile Gly Phe Gly Thr Pro Tyr Tyr
             340                 345                 350        
 Tyr Val Gly Trp Tyr Glu Cys Gly Val Ser Ile Pro Gly Lys Trp
         355                 360                 365        



      <210> 727
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 727
 Met Ser Gly His Phe Leu Leu Ala Pro Ile Pro Glu Ser Ser Ser Asp
   1               5                  10                  15    
 Tyr Leu Leu Pro Lys Asp Ile Lys Leu Ala Val Leu Gly Ala Gly Arg
              20                  25                  30        
 Val Gly Lys Ser Ala Met Ile Val Arg Phe Leu Thr Lys Arg Phe Ile
          35                  40                  45            
 Gly Asp Tyr Glu Pro Asn Thr Gly Lys Leu Tyr Ser Arg Leu Val Tyr
      50                  55                  60                
 Val Glu Gly Asp Gln Leu Ser Leu Gln Ile Gln Asp Thr Pro Gly Gly
  65                  70                  75                  80
 Val Gln Ile Gln Asp Ser Leu Pro Gln Val Val Asp Ser Leu Ser Lys
                  85                  90                  95    
 Cys Val Gln Trp Ala Glu Gly Phe Leu Leu Val Tyr Ser Ile Thr Asp
             100                 105                 110        
 Tyr Asp Ser Tyr Leu Ser Ile Arg Pro Leu Tyr Gln His Ile Arg Lys
         115                 120                 125            
 Val His Pro Asp Ser Lys Ala Pro Val Ile Ile Val Gly Asn Lys Gly
     130                 135                 140                
 Asp Leu Leu His Ala Arg Gln Val Gln Thr Gln Asp Gly Ile Gln Leu
 145                 150                 155                 160
 Ala Asn Glu Leu Gly Ser Leu Phe Leu Glu Ile Ser Thr Ser Glu Asn
                 165                 170                 175    
 Tyr Glu Asp Val Cys Asp Val Phe Gln His Leu Cys Lys Glu Val Ser
             180                 185                 190        
 Lys Met His Gly Leu Ser Gly Glu Arg Arg Arg Ala Ser Ile Ile Pro
         195                 200                 205            
 Arg Pro Arg Ser Pro Asn Met Gln Asp Leu Lys Arg Arg Phe Lys Gln
     210                 215                 220                
 Ala Leu Ser Pro Lys Val Lys Ala Pro Ser Ala Leu Gly
 225                 230                 235        



      <210> 728
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 728
 Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Val Ala Val Val Ser
   1               5                  10                  15    
 Gly Pro Leu Leu Gly Pro Trp Leu Leu Pro Arg Pro Leu Pro Arg Pro
              20                  25                  30        
 Tyr Thr Trp Pro Leu Tyr Cys Ala His Pro Asp Leu Arg Gly Glu Ala
          35                  40                  45            
 Ala Gly Leu Leu Phe Leu Gly His Ala Cys Leu Arg Gly Ser Val Asn
      50                  55                  60                
 Leu Arg Arg Asp Gln Trp Leu Pro Val His Leu Leu Gln Val Thr Ala
  65                  70                  75                  80
 Leu Gly Arg Arg Gly His Gly Glu Gly Arg Leu Gly Cys Arg Cys Ala
                  85                  90                  95    
 Pro Val Met Pro Trp Ala Arg Gly Arg Asp Thr Cys Arg Gly Arg Gly
             100                 105                 110        
 Leu Pro Glu Ala Gly Met Met Ile Pro His Gly Asn Lys Cys Leu Ile
         115                 120                 125            
 Thr Thr Gly Arg Gln Arg Lys Gln Glu Ala Gly Arg Leu Asp Glu Gly
     130                 135                 140                
 Glu Asn Cys Pro Val Gly Leu Leu Gly Pro Glu Gln Glu Val Arg Gly
 145                 150                 155                 160
 Asp Ser Leu Arg Gly Thr Ser Gly Pro Lys Leu Arg Pro Arg Met Trp
                 165                 170                 175    
 Pro Val Pro Ile Ser Val Pro Asn Ala Arg Leu Cys Phe Ser Gly Ala
             180                 185                 190        
 Arg Glu Gly His Leu Pro Ser Leu Leu Ala Met Ile His Val Arg His
         195                 200                 205            
 Cys Thr Pro Ile Pro Ala Leu Leu Val Cys Cys Gly Ala Thr Ala Val
     210                 215                 220                
 Ile Met Leu Val Gly Asp Thr Tyr Thr Leu Ile Asn Tyr Val Ser Phe
 225                 230                 235                 240
 Ile Asn Tyr Leu Cys Tyr Gly Val Thr Ile Gln Gly Pro Ala Ala Ala
                 245                 250                 255    
 Ala Leu Glu Ala Ala Cys Thr Pro Gln Ala His Gln Gly Glu Pro Ser
             260                 265                 270        
 His Pro Arg Gly Val Leu Gly Leu Leu Gly Leu Pro Ala Gly Leu Gln
         275                 280                 285            
 Leu His Leu Arg Ala Tyr Gly Leu Trp Gly Arg Arg His His His Pro
     290                 295                 300                
 Tyr Gly Gly Ala His Phe Leu Ser Gly Ser Val Leu Glu Lys Gln Thr
 305                 310                 315                 320
 Lys Val Cys Ala Gln Thr His Arg Val His Asp Thr Leu Gly Pro Gly
                 325                 330                 335    
 Ala Val Phe Arg Gly Leu Pro Pro Gly Arg Pro Arg Arg Gly Gly Glu
             340                 345                 350        
 Trp Pro Leu Pro Thr Leu Pro Ala Ala Cys His Arg Gln Ala Leu Glu
         355                 360                 365            
 Ala Thr Met Arg Phe Leu
     370                



      <210> 729
      <211> 50
      <212> PRT
      <213> Homo sapiens


      <400> 729
 Met Ser Gln Cys Gln Pro Arg Phe Lys Ile Glu Glu Ile Asp Tyr Thr
   1               5                  10                  15    
 Ser Thr Trp Lys Lys Ile Gln Gly His Ile Ala Lys Glu Trp Lys Glu
              20                  25                  30        
 Leu Thr Ala Ala Ile Phe Glu Lys Val His His Thr His Arg Phe Arg
          35                  40                  45            
 Phe Leu
      50



      <210> 730
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 730
 Met Ser Val Ala Phe Val Pro Asp Trp Leu Arg Gly Lys Ala Glu Val
   1               5                  10                  15    
 Asn Gln Glu Thr Ile Gln Arg Leu Leu Glu Glu Asn Asp Gln Leu Ile
              20                  25                  30        
 Arg Cys Ile Val Glu Tyr Gln Asn Lys Gly Arg Gly Asn Glu Cys Val
          35                  40                  45            
 Gln Tyr Gln His Val Leu His Arg Asn Leu Ile Tyr Leu Ala Thr Ile
      50                  55                  60                
 Ala Asp Ala Ser Pro Thr Ser Thr Ser Lys Ala Met Glu
  65                  70                  75        



      <210> 731
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 731
 Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val Leu Leu Cys Trp Val
   1               5                  10                  15    
 Ser Ala Asp Ile Arg Cys His Ser Cys Tyr Lys Val Pro Val Leu Gly
              20                  25                  30        
 Cys Val Asp Arg Gln Ser Cys Arg Leu Glu Pro Gly Gln Gln Cys Leu
          35                  40                  45            
 Thr Thr His Ala Tyr Leu Gly Lys Met Trp Val Phe Ser Asn Leu Arg
      50                  55                  60                
 Cys Gly Thr Pro Glu Glu Pro Cys Gln Glu Gly Phe Asn Gln Thr Asn
  65                  70                  75                  80
 Arg Lys Leu Gly Leu Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp Asn
                  85                  90                  95    
 Cys Asn Ser Ala Gly Pro Arg Pro Thr Pro Ala Leu Gly Leu Val Phe
             100                 105                 110        
 Leu Thr Ser Leu Ala Gly Leu Gly Leu Trp Leu Leu His
         115                 120                 125



      <210> 732
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 732
 Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly
   1               5                  10                  15    
 Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val
              20                  25                  30        
 Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val
          35                  40                  45            
 Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln
      50                  55                  60                
 Pro Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Lys Gly Ile Asn
  65                  70                  75                  80
 Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg
                  85                  90                  95    
 Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val
             100                 105                 110        
 Ser Asp Thr Val Pro Glu Thr Ala Gly Glu Leu Asn Thr Asn Leu Leu
         115                 120                 125            
 Arg Cys
     130



      <210> 733
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 733
 Met Cys Pro His Leu Arg Pro Val Pro Gly Thr Pro Cys Leu Pro Arg
   1               5                  10                  15    
 Trp Ala Ala Leu Ser Pro Gly Asp Ser Val Pro Ser Met Pro Trp Leu
              20                  25                  30        
 Ala Glu Thr Leu Asn Ser Ser Leu Gly Thr Val Gly Leu Ser Pro Pro
          35                  40                  45            
 Leu Leu Pro Cys Leu Pro Leu Ser Val Pro Gly Arg Leu Gly Ala Gly
      50                  55                  60                
 Gln Pro Glu Ala Glu Thr Lys Ala Pro His Arg Arg Ala Gln Glu Val
  65                  70                  75                  80
 Pro Ala Leu Gly Thr Ala Ser Ser Val Ala Pro Ala Arg His Gln Phe
                  85                  90                  95    
 Pro Glu Gly Arg Ser Arg Pro Pro Pro Ala Ala Ala Val Gly Leu His
             100                 105                 110        
 Ser Pro Ala Gln Pro Lys Ala Pro Arg Ser Trp Asp Ser Ala Thr Pro
         115                 120                 125            
 Ser Glu Met Leu Cys Pro Phe Ser Pro Val Pro Leu Asp Ala Pro Ser
     130                 135                 140                
 Pro Gln Cys Ser Gly Asp Pro Trp Gly Thr Glu Gln Glu Gly Leu Asp
 145                 150                 155                 160
 Pro Val Ala Gln Pro Lys Ala Thr Arg Gln Pro Gln Pro Ala Gln Pro
                 165                 170                 175    
 Pro Ser Ser Ala Trp Gly Leu Ala Thr Gly Ser Ser Gln Trp Thr Pro
             180                 185                 190        
 Ala Pro Arg Gly Gly Arg Gly Thr Ala Pro Thr Ala Gln Gln Thr Cys
         195                 200                 205            
 Glu Leu Pro Glu Cys Asn Leu Cys Asp Val Phe Gln Arg
     210                 215                 220    



      <210> 734
      <211> 441
      <212> PRT
      <213> Homo sapiens


      <400> 734
 Met Leu Gln Cys Pro Ser Val Glu Val Ser Phe Leu Pro Leu Ile Val
   1               5                  10                  15    
 Asn Thr Val Ala Leu Pro Asp Glu Leu Ser Tyr Ile Cys Thr His Gly
              20                  25                  30        
 Glu Asp Trp Asp Val Ala Tyr Ile Ile His Leu Tyr Pro Ser Leu Thr
          35                  40                  45            
 Leu Arg Asn Leu Leu Pro Tyr Ser Leu Arg Tyr Leu Leu Glu Gly Thr
      50                  55                  60                
 Ala Glu Thr His Glu Leu Ala Glu Gly Ser Thr Ala Asp Val Leu His
  65                  70                  75                  80
 Ser Arg Ile Ser Gly Glu Ile Met Glu Leu Val Leu Val Lys Tyr Gln
                  85                  90                  95    
 Gly Lys Asn Trp Asn Gly His Phe Arg Ile Arg Asp Thr Leu Pro Glu
             100                 105                 110        
 Phe Phe Pro Val Cys Phe Ser Ser Asp Ser Thr Glu Val Thr Thr Val
         115                 120                 125            
 Asp Leu Ser Val His Val Arg Arg Ile Gly Ser Arg Met Val Leu Ser
     130                 135                 140                
 Val Phe Ser Pro Tyr Trp Leu Ile Asn Lys Thr Thr Arg Val Leu Gln
 145                 150                 155                 160
 Tyr Arg Ser Glu Asp Ile His Val Lys His Pro Ala Asp Phe Arg Asp
                 165                 170                 175    
 Ile Ile Leu Phe Ser Phe Lys Lys Lys Asn Ile Phe Thr Lys Asn Lys
             180                 185                 190        
 Val Gln Leu Lys Ile Ser Thr Ser Ala Trp Ser Ser Ser Phe Ser Leu
         195                 200                 205            
 Asp Thr Val Gly Ser Tyr Gly Cys Val Lys Cys Pro Ala Asn Asn Met
     210                 215                 220                
 Glu Tyr Leu Val Gly Val Ser Ile Lys Met Ser Ser Phe Asn Leu Ser
 225                 230                 235                 240
 Arg Ile Val Thr Leu Thr Pro Phe Cys Thr Ile Ala Asn Lys Ser Ser
                 245                 250                 255    
 Leu Glu Leu Glu Val Gly Glu Ile Ala Ser Asp Gly Ser Met Pro Thr
             260                 265                 270        
 Asn Lys Trp Asn Tyr Ile Ala Ser Ser Glu Cys Leu Pro Phe Trp Pro
         275                 280                 285            
 Glu Asn Leu Ser Gly Lys Leu Cys Val Arg Val Val Gly Cys Glu Gly
     290                 295                 300                
 Ser Ser Lys Pro Phe Phe Tyr Asn Arg Gln Asp Asn Gly Thr Leu Leu
 305                 310                 315                 320
 Ser Leu Glu Asp Leu Asn Gly Gly Ile Leu Val Asp Val Asn Thr Ala
                 325                 330                 335    
 Glu His Ser Thr Val Ile Thr Phe Ser Asp Tyr His Glu Gly Ser Ala
             340                 345                 350        
 Pro Ala Leu Ile Met Asn His Thr Pro Trp Asp Ile Leu Thr Tyr Lys
         355                 360                 365            
 Gln Ser Gly Ser Pro Glu Glu Met Val Leu Leu Pro Arg Gln Ala Arg
     370                 375                 380                
 Leu Phe Ala Trp Ala Asp Pro Thr Gly Thr Arg Lys Leu Thr Trp Thr
 385                 390                 395                 400
 Tyr Ala Ala Asn Val Gly Glu His Asp Leu Leu Lys Val Ser Phe Asp
                 405                 410                 415    
 Val Asn Glu Cys Tyr Met Ser Tyr Leu Thr Val Lys Glu Val Glu Lys
             420                 425                 430        
 Leu Ser Ser Leu Thr Pro Cys Pro Asn
         435                 440    



      <210> 735
      <211> 464
      <212> PRT
      <213> Homo sapiens


      <400> 735
 Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser
   1               5                  10                  15    
 Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly
              20                  25                  30        
 Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys
          35                  40                  45            
 Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg
      50                  55                  60                
 Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys
  65                  70                  75                  80
 Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser
                  85                  90                  95    
 Thr Thr Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu
             100                 105                 110        
 Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu
         115                 120                 125            
 Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser
     130                 135                 140                
 Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe
 145                 150                 155                 160
 Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp
                 165                 170                 175    
 Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu
             180                 185                 190        
 Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys
         195                 200                 205            
 Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu
     210                 215                 220                
 Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu
 225                 230                 235                 240
 Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr
                 245                 250                 255    
 Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr
             260                 265                 270        
 Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg
         275                 280                 285            
 Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile
     290                 295                 300                
 Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu
 305                 310                 315                 320
 Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr
                 325                 330                 335    
 Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu
             340                 345                 350        
 Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu
         355                 360                 365            
 Asp Arg Gln His Val Gln His Gln Leu His Val Ile Leu Lys Glu Leu
     370                 375                 380                
 Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu
 385                 390                 395                 400
 His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr
                 405                 410                 415    
 Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala
             420                 425                 430        
 Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro
         435                 440                 445            
 Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys
     450                 455                 460                





      <210> 736
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 736
 Met Lys Ser Asp Ser Ser Thr Ser Ala Ala Pro Leu Arg Gly Leu Gly
   1               5                  10                  15    
 Gly Pro Leu Arg Ser Ser Glu Pro Val Arg Ala Val Pro Ala Arg Ala
              20                  25                  30        
 Pro Ala Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Val Val His
          35                  40                  45            
 Leu Asp Phe Arg Ala Ala Leu Glu Thr Cys Glu Arg Ala Trp Gln Ser
      50                  55                  60                
 Leu Ala Asn His Ala Val Ala Glu Glu Pro Ala Gly Thr Ser Leu Glu
  65                  70                  75                  80
 Val Lys Cys Ser Leu Cys Val Val Gly Ile Gln Ala Leu Ala Glu Met
                  85                  90                  95    
 Asp Arg Trp Gln Glu Val Leu Ser Trp Val Leu Gln Tyr Tyr Gln Val
             100                 105                 110        
 Pro Glu Lys Leu Pro Pro Lys Val Leu Glu Leu Cys Ile Leu Leu Tyr
         115                 120                 125            
 Ser Lys Met Gln Glu Pro Gly Ala Val Leu Asp Val Val Gly Ala Trp
     130                 135                 140                
 Leu Gln Asp Pro Ala Asn Gln Asn Leu Pro Glu Tyr Gly Ala Leu Ala
 145                 150                 155                 160
 Glu Phe His Val Gln Arg Val Leu Leu Pro Leu Gly Cys Leu Ser Glu
                 165                 170                 175    
 Ala Glu Glu Leu Val Val Gly Ser Ala Ala Phe Gly Glu Glu Arg Arg
             180                 185                 190        
 Leu Asp Val Leu Gln Ala Ile His Thr Ala Arg Gln Gln Gln Lys Gln
         195                 200                 205            
 Glu His Ser Gly Ser Glu Glu Ala Gln Lys Pro Asn Leu Glu Gly Ser
     210                 215                 220                
 Val Ser His Lys Phe Leu Ser Leu Pro Met Leu Val Arg Gln Leu Trp
 225                 230                 235                 240
 Asp Ser Ala Val Ser His Phe Phe Ser Leu Pro Phe Lys Lys Ser Leu
                 245                 250                 255    
 Leu Ala Ala Leu Ile Leu Cys Leu Leu Val Val Arg Phe Asp Pro Ala
             260                 265                 270        
 Ser Pro Ser Ser Leu His Phe Leu Tyr Lys Leu Ala Gln Leu Phe Arg
         275                 280                 285            
 Trp Ile Arg Lys Ala Ala Phe Ser Arg Leu Tyr Gln Leu Arg Ile Arg
     290                 295                 300                
 Asp
 305



      <210> 737
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 737
 Met Pro Ser Thr Val Ile Val Met Cys Gln Leu Lys Ala Ile Phe Leu
   1               5                  10                  15    
 Gly Ser Ala His Val Ser Leu Ser Glu Cys His Lys Cys Ile Leu Phe
              20                  25                  30        
 Tyr Ile Tyr Leu Lys Thr Ala Lys Lys Leu Gly Glu Met Glu Met Pro
          35                  40                  45            
 Ala Gln Ile Val Lys Ile Glu Met Asp Thr Asp Gln Lys Cys Trp Trp
      50                  55                  60                
 Leu Tyr Lys Gly Cys Phe Leu Lys Asn Leu Lys Arg Gly Glu Gly Arg
  65                  70                  75                  80
 Thr Trp Leu Gly Lys Gln Met Thr Val Tyr Ser Thr Ser Leu Cys Gly
                  85                  90                  95    
 Leu
    



      <210> 738
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 738
 Met Glu Gly Gly Arg Arg Asp His His Thr Met Thr Val Leu Trp Gly
   1               5                  10                  15    
 Thr Gln Glu Ile Ile Val Ala Glu Phe His Lys Lys Ile Lys Glu Ala
              20                  25                  30        
 Phe Glu Val Phe Asp His Glu Ser Asn Asn Thr Val Asp Val Arg Glu
          35                  40                  45            
 Ile Gly Thr Ile Ile Arg Ser Leu Gly Cys Cys Pro Thr Glu Gly Glu
      50                  55                  60                
 Leu His Asp Leu Ile Ala Glu Val Glu Glu Glu Glu Pro Thr Gly Tyr
  65                  70                  75                  80
 Ile Arg Phe Glu Lys Phe Leu Pro Val Met Thr Glu Ile Leu Leu Glu
                  85                  90                  95    
 Arg Lys Tyr Arg Pro Ile Pro Glu Asp Val Leu Leu Arg Ala Phe Glu
             100                 105                 110        
 Val Leu Asp Ser Ala Lys Arg Gly Phe Leu Thr Lys Asp Glu Leu Ile
         115                 120                 125            
 Lys Tyr Met Thr Glu Glu Glu Thr Gly Lys Leu Arg Trp Gly Ala Val
     130                 135                 140                
 Lys
 145



      <210> 739
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 739
 Met Glu Gly Gly Arg Arg Asp His His Thr Met Thr Val Leu Trp Gly
   1               5                  10                  15    
 Thr Gln Glu Ile Ile Val Ala Glu Phe His Lys Lys Ile Lys Glu Ala
              20                  25                  30        
 Phe Glu Val Phe Asp His Glu Ser Asn Asn Thr Val Asp Val Arg Glu
          35                  40                  45            
 Ile Gly Thr Ile Ile Arg Ser Leu Gly Cys Cys Pro Thr Glu Gly Glu
      50                  55                  60                
 Leu His Asp Leu Ile Ala Glu Val Glu Glu Glu Glu Pro Thr Gly Tyr
  65                  70                  75                  80
 Ile Arg Phe Glu Lys Phe Leu Pro Val Met Thr Glu Ile Leu Leu Glu
                  85                  90                  95    
 Arg Lys Tyr Arg Pro Ile Pro Glu Asp Val Leu Leu Arg Ala Phe Glu
             100                 105                 110        
 Val Leu Asp Ser Ala Lys Arg Gly Phe Leu Thr Lys Asp Glu Leu Ile
         115                 120                 125            
 Lys Tyr Met Thr Glu Glu Gly Gly Val Val Ile Thr Pro Ile Leu Glu
     130                 135                 140                
 Thr Gly Lys Leu Arg Trp Gly Ala Val Lys
 145                 150                



      <210> 740
      <211> 926
      <212> PRT
      <213> Homo sapiens


      <400> 740
 Met Lys Lys Thr Arg Ser Thr Thr Leu Arg Arg Ala Trp Pro Ser Ser
   1               5                  10                  15    
 Asp Phe Ser Asp Arg Ala Ser Asp Arg Met Arg Ser Arg Ser Glu Lys
              20                  25                  30        
 Asp Tyr Arg Leu His Lys Arg Phe Pro Ala Ala Phe Ala Pro Gln Ala
          35                  40                  45            
 Ser Arg Gly Tyr Met Thr Ser Gly Asp Val Ser Pro Ile Ser Met Ser
      50                  55                  60                
 Pro Ile Ser Gln Ser Gln Phe Ile Pro Leu Gly Glu Ile Leu Cys Leu
  65                  70                  75                  80
 Ala Ile Ser Ala Met Asn Ser Ala Arg Lys Pro Val Thr Gln Glu Ala
                  85                  90                  95    
 Leu Met Glu His Leu Thr Thr Cys Phe Pro Gly Val Pro Thr Pro Ser
             100                 105                 110        
 Gln Glu Ile Leu Arg His Thr Leu Asn Thr Leu Val Arg Glu Arg Lys
         115                 120                 125            
 Ile Tyr Pro Thr Pro Asp Gly Tyr Phe Ile Val Thr Pro Gln Thr Tyr
     130                 135                 140                
 Phe Ile Thr Pro Ser Leu Ile Arg Thr Asn Ser Lys Trp Tyr His Leu
 145                 150                 155                 160
 Asp Glu Arg Ile Pro Asp Arg Ser Gln Cys Thr Ser Pro Gln Pro Gly
                 165                 170                 175    
 Thr Ile Thr Pro Ser Ala Ser Gly Cys Val Arg Glu Arg Thr Leu Pro
             180                 185                 190        
 Arg Asn His Cys Asp Ser Cys His Cys Cys Arg Glu Asp Val His Ser
         195                 200                 205            
 Thr His Ala Pro Thr Leu Gln Arg Lys Ser Ala Lys Asp Cys Lys Asp
     210                 215                 220                
 Pro Tyr Cys Pro Pro Ser Leu Cys Gln Val Pro Pro Thr Glu Lys Ser
 225                 230                 235                 240
 Lys Ser Thr Val Asn Phe Ser Tyr Lys Thr Glu Thr Leu Ser Lys Pro
                 245                 250                 255    
 Lys Asp Ser Glu Lys Gln Ser Lys Lys Phe Gly Leu Lys Leu Phe Arg
             260                 265                 270        
 Leu Ser Phe Lys Lys Asp Lys Thr Lys Gln Leu Ala Asn Phe Ser Ala
         275                 280                 285            
 Gln Phe Pro Pro Glu Glu Trp Pro Leu Arg Asp Glu Asp Thr Pro Ala
     290                 295                 300                
 Thr Ile Pro Arg Glu Val Glu Met Glu Ile Ile Arg Arg Ile Asn Pro
 305                 310                 315                 320
 Asp Leu Thr Val Glu Asn Val Met Arg His Thr Ala Leu Met Lys Lys
                 325                 330                 335    
 Leu Glu Glu Glu Lys Ala Gln Arg Ser Lys Ala Gly Ser Ser Ala His
             340                 345                 350        
 His Ser Gly Arg Ser Lys Lys Ser Arg Thr His Arg Lys Ser His Gly
         355                 360                 365            
 Lys Ser Arg Ser His Ser Lys Thr Arg Val Ser Lys Gly Asp Pro Ser
     370                 375                 380                
 Asp Gly Ser His Leu Asp Ile Pro Ala Glu Arg Glu Tyr Asp Phe Cys
 385                 390                 395                 400
 Asp Pro Leu Thr Arg Val Pro Arg Glu Gly Cys Phe Ile Ile Glu His
                 405                 410                 415    
 Lys Gly Asp Asn Phe Ile Met His Ser Asn Thr Asn Val Leu Glu Ser
             420                 425                 430        
 His Phe Pro Met Thr Pro Glu Trp Asp Val Ser Gly Glu Leu Ala Lys
         435                 440                 445            
 Arg Arg Thr Glu Met Pro Phe Pro Glu Pro Ser Arg Gly Ser Ser His
     450                 455                 460                
 Ser Lys Val His Arg Ser His Ser His Thr Gln Asp Arg Arg Ser Arg
 465                 470                 475                 480
 Asn Glu Arg Ser Asn Lys Ala Lys Glu Arg Ser Arg Ser Met Asp Asn
                 485                 490                 495    
 Ser Lys Gly Pro Leu Gly Ala Ser Ser Leu Gly Thr Pro Glu Asp Leu
             500                 505                 510        
 Ala Glu Gly Cys Ser Gln Asp Asp Gln Thr Pro Ser Gln Ser Tyr Ile
         515                 520                 525            
 Asp Asp Ser Thr Leu Arg Pro Ala Gln Thr Val Ser Leu Gln Arg Ala
     530                 535                 540                
 His Ile Ser Ser Thr Ser Tyr Lys Glu Val Cys Ile Pro Glu Ile Val
 545                 550                 555                 560
 Ser Gly Ser Lys Glu Pro Ser Ser Ala Cys Ser Leu Leu Glu Pro Gly
                 565                 570                 575    
 Lys Pro Pro Glu Ser Leu Pro Ser Tyr Gly Glu Leu Asn Ser Cys Pro
             580                 585                 590        
 Thr Lys Thr Ala Thr Asp Asp Tyr Phe Gln Cys Asn Thr Ser Ser Glu
         595                 600                 605            
 Thr Val Leu Thr Ala Pro Ser Pro Leu Gly Lys Asn Lys Glu Asp His
     610                 615                 620                
 Asp Thr Leu Thr Leu Ala Glu Gly Val Lys Lys Leu Ser Pro Ser Asp
 625                 630                 635                 640
 Arg Gln Val Pro His Ser Ser Arg Glu Pro Val Gly His Lys Glu Glu
                 645                 650                 655    
 Ser Pro Lys Gly Pro Gly Gly Gly Pro Ala Ala Ser Gly Gly Val Ala
             660                 665                 670        
 Glu Gly Ile Ala Asn Gly Arg Leu Val Gln His His Gly Ala Glu Pro
         675                 680                 685            
 Ser Ser Leu Asp Lys Arg Lys Glu Ile Phe Ser Lys Asp Thr Leu Phe
     690                 695                 700                
 Lys Pro Leu His Ser Thr Leu Ser Val Asn Ser Tyr His Lys Ser Ser
 705                 710                 715                 720
 Leu Ser Leu Leu Lys Ser His Pro Lys Thr Pro Ala Asp Thr Leu Pro
                 725                 730                 735    
 Gly Arg Cys Glu Lys Leu Glu Pro Ser Leu Gly Thr Ser Ala Ala Gln
             740                 745                 750        
 Ala Met Pro Ala Ser Gln Arg Gln Gln Glu Ser Gly Gly Asn Gln Glu
         755                 760                 765            
 Ala Ser Phe Asp Tyr Tyr Asn Val Ser Asp Asp Asp Asp Ser Glu Glu
     770                 775                 780                
 Gly Ala Asn Lys Asn Thr Glu Glu Glu Lys Asn Arg Glu Asp Val Gly
 785                 790                 795                 800
 Thr Met Gln Trp Leu Leu Glu Arg Glu Lys Glu Arg Asp Leu Gln Arg
                 805                 810                 815    
 Lys Phe Glu Lys Asn Leu Thr Leu Leu Ala Pro Lys Glu Thr Asp Ser
             820                 825                 830        
 Ser Ser Asn Gln Arg Ala Thr His Ser Ala Arg Leu Asp Ser Met Asp
         835                 840                 845            
 Ser Ser Ser Ile Thr Val Asp Ser Gly Phe Asn Ser Pro Arg Thr Arg
     850                 855                 860                
 Glu Ser Leu Ala Ser Asn Thr Ser Ser Ile Val Glu Ser Asn Arg Arg
 865                 870                 875                 880
 Gln Asn Pro Ala Leu Ser Pro Ala His Gly Gly Ala Gly Pro Ala Phe
                 885                 890                 895    
 Asn Phe Arg Ala Ser Ala Glu Pro Pro Thr Asn Glu Ala Glu Lys Leu
             900                 905                 910        
 Gln Lys Pro Ser Asn Cys Leu Gln Ala Ser Val Thr Ser Val
         915                 920                 925    



      <210> 741
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 741
 Met Lys Ile Leu Leu Val Phe Asp Phe Asp Asn Thr Ile Ile Asp Asp
   1               5                  10                  15    
 Asn Ser Asp Thr Trp Ile Val Gln Cys Ala Pro Asn Lys Lys Leu Pro
              20                  25                  30        
 Ile Glu Leu Arg Asp Ser Tyr Arg Lys Gly Phe Trp Thr Glu Phe Met
          35                  40                  45            
 Gly Arg Val Phe Lys Tyr Leu Gly Asp Lys Gly Val Arg Glu His Glu
      50                  55                  60                
 Met Lys Arg Ala Val Thr Ser Leu Pro Phe Thr Pro Gly Met Val Glu
  65                  70                  75                  80
 Leu Phe Asn Phe Ile Arg Lys Asn Lys Asp Lys Phe Asp Cys Ile Ile
                  85                  90                  95    
 Ile Ser Asp Ser Asn Ser Val Phe Ile Asp Trp Val Leu Glu Ala Ala
             100                 105                 110        
 Ser Phe His Asp Ile Phe Asp Lys Val Phe Thr Asn Pro Ala Ala Phe
         115                 120                 125            
 Asn Ser Asn Gly His Leu Thr Val Glu Asn Tyr His Thr His Ser Cys
     130                 135                 140                
 Asn Arg Cys Pro Lys Asn Leu Cys Lys Lys Val Val Leu Ile Glu Phe
 145                 150                 155                 160
 Val Asp Lys Gln Leu Gln Gln Gly Val Asn Tyr Thr Gln Ile Val Tyr
                 165                 170                 175    
 Ile Gly Asp Gly Gly Asn Asp Val Cys Pro Val Thr Phe Leu Lys Asn
             180                 185                 190        
 Asp Asp Val Ala Met Pro Arg Lys Gly Tyr Thr Leu Gln Lys Thr Leu
         195                 200                 205            
 Ser Arg Met Ser Gln Asn Leu Glu Pro Met Glu Tyr Ser Val Val Val
     210                 215                 220                
 Trp Ser Ser Gly Val Asp Ile Ile Ser His Leu Gln Phe Leu Ile Lys
 225                 230                 235                 240
 Asp
    



      <210> 742
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 742
 Met Leu Leu Gly Arg Leu Thr Ser Gln Leu Leu Arg Ala Val Pro Trp
   1               5                  10                  15    
 Ala Gly Gly Arg Pro Pro Trp Pro Val Ser Gly Val Leu Gly Ser Arg
              20                  25                  30        
 Val Cys Gly Pro Leu Tyr Ser Thr Ser Pro Ala Gly Pro Gly Arg Ala
          35                  40                  45            
 Ala Ser Leu Pro Arg Lys Gly Ala Gln Leu Glu Leu Glu Glu Met Leu
      50                  55                  60                
 Val Pro Arg Lys Met Ser Val Lys Pro Leu Lys Ser Trp Leu Thr Ala
  65                  70                  75                  80
 Arg Cys Phe Leu Pro Arg Leu Asp Thr Gly Thr Ala Trp Thr Val Ala
                  85                  90                  95    
 Pro Pro Gln Ser Tyr Gln Cys Pro Pro Ser Gln Ile Gly Glu Gly Ala
             100                 105                 110        
 Glu Gln Gly Asp Glu Gly Val Ala Asp Ala Pro Gln Ile Gln Cys Lys
         115                 120                 125            
 Asn Val Leu Lys Ile Arg Arg Arg Lys Met Asn His His Lys Tyr Arg
     130                 135                 140                
 Lys Leu Val Lys Lys Thr Arg Phe Leu Arg Arg Lys Val Gln Glu Gly
 145                 150                 155                 160
 Arg Leu Arg Arg Lys Gln Ile Lys Phe Glu Lys Asp Leu Arg Arg Ile
                 165                 170                 175    
 Trp Leu Lys Ala Gly Leu Lys Glu Ala Pro Glu Gly Trp Gln Thr Pro
             180                 185                 190        
 Lys Ile Tyr Leu Arg Gly Lys
         195                



      <210> 743
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 743
 Met Leu Leu Gly Arg Leu Thr Ser Gln Leu Leu Arg Ala Val Pro Trp
   1               5                  10                  15    
 Ala Ser Leu Pro Arg Lys Gly Ala Gln Leu Glu Leu Glu Glu Met Leu
              20                  25                  30        
 Val Pro Arg Lys Met Ser Val Lys Pro Leu Lys Ser Trp Leu Thr Ala
          35                  40                  45            
 Arg Cys Phe Leu Pro Arg Leu Asp Thr Gly Thr Ala Trp Thr Val Ala
      50                  55                  60                
 Pro Pro Gln Ser Tyr Gln Cys Pro Pro Ser Gln Ile Gly Glu Gly Ala
  65                  70                  75                  80
 Glu Gln Gly Asp Glu Gly Val Ala Asp Ala Pro Gln Ile Gln Cys Lys
                  85                  90                  95    
 Asn Val Leu Lys Ile Arg Arg Arg Lys Met Asn His His Lys Tyr Arg
             100                 105                 110        
 Lys Leu Val Lys Lys Thr Arg Phe Leu Arg Arg Lys Val Gln Glu Gly
         115                 120                 125            
 Arg Leu Arg Arg Lys Gln Ile Lys Phe Glu Lys Asp Leu Arg Arg Ile
     130                 135                 140                
 Trp Leu Lys Ala Gly Leu Lys Glu Ala Pro Glu Gly Trp Gln Thr Pro
 145                 150                 155                 160
 Lys Ile Tyr Leu Arg Gly Lys
                 165        



      <210> 744
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 744
 Met Gly Ser Val Asn Ser Arg Gly His Lys Ala Glu Ala Gln Val Val
   1               5                  10                  15    
 Met Met Gly Leu Asp Ser Ala Gly Lys Thr Thr Leu Leu Tyr Lys Leu
              20                  25                  30        
 Lys Gly His Gln Leu Val Glu Thr Leu Pro Thr Val Gly Phe Asn Val
          35                  40                  45            
 Glu Pro Leu Lys Ala Pro Gly His Val Ser Leu Thr Leu Trp Asp Val
      50                  55                  60                
 Gly Gly Gln Ala Pro Leu Arg Ala Ser Trp Lys Asp Tyr Leu Glu Gly
  65                  70                  75                  80
 Thr Asp Ile Leu Val Tyr Val Leu Asp Ser Thr Asp Glu Ala Arg Leu
                  85                  90                  95    
 Pro Glu Ser Ala Ala Glu Leu Thr Glu Val Leu Asn Asp Pro Asn Met
             100                 105                 110        
 Ala Gly Val Pro Phe Leu Val Leu Ala Asn Lys Gln Glu Ala Pro Asp
         115                 120                 125            
 Ala Leu Pro Leu Leu Lys Ile Arg Asn Arg Leu Ser Leu Glu Arg Phe
     130                 135                 140                
 Gln Asp His Cys Trp Glu Leu Arg Gly Cys Ser Ala Leu Thr Gly Glu
 145                 150                 155                 160
 Gly Leu Pro Glu Ala Leu Gln Ser Leu Trp Ser Leu Leu Lys Ser Arg
                 165                 170                 175    
 Ser Cys Met Cys Leu Gln Ala Arg Ala His Gly Ala Glu Arg Gly Asp
             180                 185                 190        
 Gly Lys Arg Ser
         195    



      <210> 745
      <211> 811
      <212> PRT
      <213> Homo sapiens


      <400> 745
 Met Ser Pro Ser Gln Leu Leu Glu His Gln Glu Leu His Leu Lys Met
   1               5                  10                  15    
 Met Ala Pro Gln Glu Ala Val Pro Ala Glu Pro Ser Pro Lys Ala Pro
              20                  25                  30        
 Pro Leu Ser Ser Ser Thr Ile His Tyr Glu Cys Val Asp Cys Lys Ala
          35                  40                  45            
 Leu Phe Ala Ser Gln Glu Leu Trp Leu Asn His Arg Gln Thr His Leu
      50                  55                  60                
 Arg Ala Thr Pro Thr Lys Ala Pro Ala Pro Val Val Leu Gly Ser Pro
  65                  70                  75                  80
 Val Val Leu Gly Pro Pro Val Gly Gln Ala Arg Val Ala Val Glu His
                  85                  90                  95    
 Ser Tyr Arg Lys Ala Glu Glu Gly Gly Glu Gly Ala Thr Val Pro Ser
             100                 105                 110        
 Ala Ala Ala Thr Thr Thr Glu Val Val Thr Glu Val Glu Leu Leu Leu
         115                 120                 125            
 Tyr Lys Cys Phe Glu Cys Ser Gln Leu Phe Gln Leu Arg Gly Asp Phe
     130                 135                 140                
 Leu Glu His Gln Ala Thr His Phe Pro Val Pro Val Pro Glu Phe Gln
 145                 150                 155                 160
 Glu Pro Ala Leu Gln Gln Glu Val Gln Ala Ser Ser Pro Ala Glu Val
                 165                 170                 175    
 Pro Val Ser Gln Pro Asp Pro Leu Pro Ala Phe Asp His Ser Tyr Glu
             180                 185                 190        
 Leu Arg Asn Gly Glu Ala Ile Gly Arg Asp Arg Arg Gly Arg Arg Ala
         195                 200                 205            
 Arg Arg Asn Asn Ser Gly Glu Ala Gly Gly Ala Ala Thr Gln Glu Leu
     210                 215                 220                
 Phe Cys Ser Ala Cys Asp Gln Leu Phe Leu Ser Pro His Gln Leu Gln
 225                 230                 235                 240
 Gln His Leu Arg Ser His Arg Glu Gly Val Phe Lys Cys Pro Leu Cys
                 245                 250                 255    
 Ser Arg Val Phe Pro Ser Pro Ser Ser Leu Asp Gln His Leu Gly Asp
             260                 265                 270        
 His Ser Ser Glu Ser His Phe Leu Cys Val Asp Cys Gly Leu Ala Phe
         275                 280                 285            
 Gly Thr Glu Ala Leu Leu Leu Ala His Arg Arg Ala His Thr Pro Asn
     290                 295                 300                
 Pro Leu His Ser Cys Pro Cys Gly Lys Thr Phe Val Asn Leu Thr Lys
 305                 310                 315                 320
 Phe Leu Tyr His Arg Arg Thr His Gly Val Gly Gly Val Pro Leu Pro
                 325                 330                 335    
 Thr Thr Pro Val Pro Pro Glu Glu Pro Val Ile Gly Phe Pro Glu Pro
             340                 345                 350        
 Ala Pro Ala Glu Thr Gly Glu Pro Glu Ala Pro Glu Pro Pro Val Ser
         355                 360                 365            
 Glu Glu Thr Ser Ala Gly Pro Ala Ala Pro Gly Thr Tyr Arg Cys Leu
     370                 375                 380                
 Leu Cys Ser Arg Glu Phe Gly Lys Ala Leu Gln Leu Thr Arg His Gln
 385                 390                 395                 400
 Arg Phe Val His Arg Leu Glu Arg Arg His Lys Cys Ser Ile Cys Gly
                 405                 410                 415    
 Lys Met Phe Lys Lys Lys Ser His Val Arg Asn His Leu Arg Thr His
             420                 425                 430        
 Thr Gly Glu Arg Pro Phe Pro Cys Pro Asp Cys Ser Lys Pro Phe Asn
         435                 440                 445            
 Ser Pro Ala Asn Leu Ala Arg His Arg Leu Thr His Thr Gly Glu Arg
     450                 455                 460                
 Pro Tyr Arg Cys Gly Asp Cys Gly Lys Ala Phe Thr Gln Ser Ser Thr
 465                 470                 475                 480
 Leu Arg Gln His Arg Leu Val His Ala Gln His Phe Pro Tyr Arg Cys
                 485                 490                 495    
 Gln Glu Cys Gly Val Arg Phe His Arg Pro Tyr Arg Leu Leu Met His
             500                 505                 510        
 Arg Tyr His His Thr Gly Glu Tyr Pro Tyr Lys Cys Arg Glu Cys Pro
         515                 520                 525            
 Arg Ser Phe Leu Leu Arg Arg Leu Leu Glu Val His Gln Leu Val Val
     530                 535                 540                
 His Ala Gly Arg Gln Pro His Arg Cys Pro Ser Cys Gly Ala Ala Phe
 545                 550                 555                 560
 Pro Ser Ser Leu Arg Leu Arg Glu His Arg Cys Ala Ala Ala Ala Ala
                 565                 570                 575    
 Gln Ala Pro Arg Arg Phe Glu Cys Gly Thr Cys Gly Lys Lys Val Gly
             580                 585                 590        
 Ser Ala Ala Arg Leu Gln Ala His Glu Ala Ala His Ala Ala Ala Gly
         595                 600                 605            
 Pro Gly Glu Val Leu Ala Lys Glu Pro Pro Ala Pro Arg Ala Pro Arg
     610                 615                 620                
 Ala Thr Arg Ala Pro Val Ala Ser Pro Ala Ala Leu Gly Ser Thr Ala
 625                 630                 635                 640
 Thr Ala Ser Pro Ala Ala Pro Ala Arg Arg Arg Gly Leu Glu Cys Ser
                 645                 650                 655    
 Glu Cys Lys Lys Leu Phe Ser Thr Glu Thr Ser Leu Gln Val His Arg
             660                 665                 670        
 Arg Ile His Thr Gly Glu Arg Pro Tyr Pro Cys Pro Asp Cys Gly Lys
         675                 680                 685            
 Ala Phe Arg Gln Ser Thr His Leu Lys Asp His Arg Arg Leu His Thr
     690                 695                 700                
 Gly Glu Arg Pro Phe Ala Cys Glu Val Cys Gly Lys Ala Phe Ala Ile
 705                 710                 715                 720
 Ser Met Arg Leu Ala Glu His Arg Arg Ile His Thr Gly Glu Arg Pro
                 725                 730                 735    
 Tyr Ser Cys Pro Asp Cys Gly Lys Ser Tyr Arg Ser Phe Ser Asn Leu
             740                 745                 750        
 Trp Lys His Arg Lys Thr His Gln Gln Gln His Gln Ala Ala Val Arg
         755                 760                 765            
 Gln Gln Leu Ala Glu Ala Glu Ala Ala Val Gly Leu Ala Val Met Glu
     770                 775                 780                
 Thr Ala Val Glu Ala Leu Pro Leu Val Glu Ala Ile Glu Ile Tyr Pro
 785                 790                 795                 800
 Leu Ala Glu Ala Glu Gly Val Gln Ile Ser Gly
                 805                 810    



      <210> 746
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 746
 Met Ser Gly Glu Pro Gly Gln Thr Ser Val Ala Pro Pro Pro Glu Glu
   1               5                  10                  15    
 Val Glu Pro Gly Ser Gly Val Arg Ile Val Val Glu Tyr Cys Glu Pro
              20                  25                  30        
 Cys Gly Phe Glu Ala Thr Tyr Leu Glu Leu Ala Ser Ala Val Lys Glu
          35                  40                  45            
 Gln Tyr Pro Gly Ile Glu Ile Glu Ser Arg Leu Gly Gly Thr Gly Ala
      50                  55                  60                
 Phe Glu Ile Glu Ile Asn Gly Gln Leu Val Phe Ser Lys Leu Glu Asn
  65                  70                  75                  80
 Gly Gly Phe Pro Tyr Glu Lys Asp Leu Ile Glu Ala Ile Arg Arg Ala
                  85                  90                  95    
 Ser Asn Gly Glu Thr Leu Glu Lys Ile Thr Asn Ser Arg Pro Pro Cys
             100                 105                 110        
 Val Ile Leu
         115



      <210> 747
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 747
 Met Gly Thr Phe Thr Asn Ser Ala Leu Trp Ile Ala Leu Gln Ile Met
   1               5                  10                  15    
 Phe Glu Thr Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Glu
              20                  25                  30        
 Leu Ser Leu Tyr Ala Ser Gly Arg Thr Thr Gly Arg Trp Leu Gly Gly
          35                  40                  45            
 Thr Ala Ser Trp Leu Glu Arg Thr Ala Arg Asp Gly Ile Glu Trp Ser
      50                  55                  60                





      <210> 748
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 748
 Met Leu His Ala Leu Leu Arg Ser Arg Met Ile Gln Gly Arg Ile Leu
   1               5                  10                  15    
 Leu Leu Thr Ile Cys Ala Ala Gly Ile Gly Gly Thr Phe Gln Phe Gly
              20                  25                  30        
 Tyr Asn Leu Ser Ile Ile Asn Ala Pro Thr Leu His Ile Gln Glu Phe
          35                  40                  45            
 Thr Asn Glu Thr Trp Gln Ala Arg Thr Gly Glu Pro Leu Pro Asp His
      50                  55                  60                
 Leu Val Leu Leu Met Trp Ser Leu Ile Val Ser Leu Tyr Pro Leu Gly
  65                  70                  75                  80
 Gly Leu Phe Gly Ala Leu Leu Ala Gly Pro Leu Ala Ile Thr Leu Gly
                  85                  90                  95    
 Arg Lys Lys Ser Leu Leu Val Asn Asn Ile Phe Val Val Ser Ala Ala
             100                 105                 110        
 Ile Leu Phe Gly Phe Ser Arg Lys Ala Gly Ser Phe Glu Met Ile Met
         115                 120                 125            
 Leu Gly Arg Leu Leu Val Gly Val Asn Ala Gly Val Ser Met Asn Ile
     130                 135                 140                
 Gln Pro Met Tyr Leu Gly Glu Ser Ala Pro Lys Glu Leu Arg Gly Ala
 145                 150                 155                 160
 Val Ala Met Ser Ser Ala Ile Phe Thr Ala Leu Gly Ile Val Met Gly
                 165                 170                 175    
 Gln Val Val Gly Leu Arg
             180        



      <210> 749
      <211> 301
      <212> PRT
      <213> Homo sapiens


      <400> 749
 Met Ala Ser Ala Ala Arg Glu Leu Val Ile Gln Arg Leu Ser Leu Val
   1               5                  10                  15    
 Arg Ser Leu Cys Glu Ser Glu Glu Gln Arg Leu Leu Glu Gln Val His
              20                  25                  30        
 Gly Glu Glu Glu Arg Ala His Gln Ser Ile Leu Thr Gln Arg Val His
          35                  40                  45            
 Trp Ala Glu Ala Leu Gln Lys Leu Asp Thr Ile Arg Thr Gly Leu Val
      50                  55                  60                
 Gly Met Leu Thr His Leu Asp Asp Leu Gln Leu Ile Gln Lys Glu Gln
  65                  70                  75                  80
 Glu Ile Phe Glu Arg Thr Glu Glu Ala Glu Gly Ile Leu Asp Pro Gln
                  85                  90                  95    
 Glu Ser Glu Met Leu Asn Phe Asn Glu Lys Cys Thr Arg Ser Pro Leu
             100                 105                 110        
 Leu Thr Gln Leu Trp Ala Thr Ala Val Leu Gly Ser Leu Ser Gly Thr
         115                 120                 125            
 Glu Asp Ile Arg Ile Asp Glu Arg Thr Val Ser Pro Phe Leu Gln Leu
     130                 135                 140                
 Ser Asp Asp Arg Lys Thr Leu Thr Phe Ser Thr Lys Lys Ser Lys Ala
 145                 150                 155                 160
 Cys Ala Asp Gly Pro Glu Arg Phe Asp His Trp Pro Asn Ala Leu Ala
                 165                 170                 175    
 Ala Thr Ser Phe Gln Asn Gly Leu His Ala Trp Met Val Asn Val Gln
             180                 185                 190        
 Asn Ser Cys Ala Tyr Lys Val Gly Val Ala Ser Gly His Leu Pro Arg
         195                 200                 205            
 Lys Gly Ser Gly Ser Asp Cys Arg Leu Gly His Asn Ala Phe Ser Trp
     210                 215                 220                
 Val Phe Ser Arg Tyr Asp Gln Glu Phe Arg Phe Ser His Asn Gly Gln
 225                 230                 235                 240
 His Glu Pro Leu Gly Leu Leu Arg Gly Pro Ala Gln Leu Gly Val Val
                 245                 250                 255    
 Leu Asp Leu Gln Val Gln Glu Leu Leu Phe Tyr Glu Pro Ala Ser Gly
             260                 265                 270        
 Thr Val Leu Cys Ala His His Val Ser Phe Pro Gly Pro Leu Phe Pro
         275                 280                 285            
 Val Phe Ala Val Ala Asp Gln Thr Ile Ser Ile Val Arg
     290                 295                 300    



      <210> 750
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 750
 Met Ala Gln Thr Asp Lys Pro Thr Cys Ile Pro Pro Glu Leu Pro Lys
   1               5                  10                  15    
 Met Leu Lys Glu Phe Ala Lys Ala Ala Ile Arg Ala Gln Pro Gln Asp
              20                  25                  30        
 Leu Ile Gln Trp Gly Ala Glu Arg Asp Leu Gln Arg Leu Leu Ser Arg
          35                  40                  45            
 Trp Ser Leu His Asn Asn Arg Cys Gly Pro Gly Leu Lys
      50                  55                  60    



      <210> 751
      <211> 337
      <212> PRT
      <213> Homo sapiens


      <400> 751
 Met Lys Arg Pro Cys Glu Glu Thr Thr Ser Glu Ser Asp Met Asp Glu
   1               5                  10                  15    
 Thr Ile Asp Val Gly Ser Glu Asn Asn Tyr Ser Gly Gln Ser Thr Ser
              20                  25                  30        
 Ser Val Ile Arg Leu Asn Ser Pro Thr Thr Thr Ser Gln Ile Met Ala
          35                  40                  45            
 Arg Lys Lys Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg Ile
      50                  55                  60                
 Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Thr Ala Phe Glu
  65                  70                  75                  80
 Lys Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu Ile Leu Gln Met Thr
                  85                  90                  95    
 Val Asp His Leu Lys Met Leu Gln Ala Thr Gly Gly Lys Gly Tyr Phe
             100                 105                 110        
 Asp Ala His Ala Leu Ala Met Asp Phe Met Ser Ile Gly Phe Arg Glu
         115                 120                 125            
 Cys Leu Thr Glu Val Ala Arg Tyr Leu Ser Ser Val Glu Gly Leu Asp
     130                 135                 140                
 Ser Ser Asp Pro Leu Arg Val Arg Leu Val Ser His Leu Ser Thr Cys
 145                 150                 155                 160
 Ala Thr Gln Arg Glu Ala Ala Ala Met Thr Ser Ser Met Ala His His
                 165                 170                 175    
 His His Pro Leu His Pro His His Trp Ala Ala Ala Phe His His Leu
             180                 185                 190        
 Pro Ala Ala Leu Leu Gln Pro Asn Gly Leu His Ala Ser Glu Ser Thr
         195                 200                 205            
 Pro Cys Arg Leu Ser Thr Thr Ser Glu Val Pro Pro Ala His Gly Ser
     210                 215                 220                
 Ala Leu Leu Thr Ala Thr Phe Ala His Ala Asp Ser Ala Leu Arg Met
 225                 230                 235                 240
 Pro Ser Thr Gly Ser Val Ala Pro Cys Val Pro Pro Leu Ser Thr Ser
                 245                 250                 255    
 Leu Leu Ser Leu Ser Ala Thr Val His Ala Ala Ala Ala Ala Ala Thr
             260                 265                 270        
 Ala Ala Ala His Ser Phe Pro Leu Ser Phe Ala Gly Ala Phe Pro Met
         275                 280                 285            
 Leu Pro Pro Asn Ala Ala Ala Ala Val Ala Ala Ala Thr Ala Ile Ser
     290                 295                 300                
 Pro Pro Leu Ser Val Ser Ala Thr Ser Ser Pro Gln Gln Thr Ser Ser
 305                 310                 315                 320
 Gly Thr Asn Asn Lys Pro Tyr Arg Pro Trp Gly Thr Glu Val Gly Ala
                 325                 330                 335    
 Phe
    



      <210> 752
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 752
 Met Glu Val Pro Asn Val Lys Asp Phe Gln Trp Lys Arg Leu Ala Pro
   1               5                  10                  15    
 Leu Pro Ser Arg Arg Val Tyr Cys Ser Leu Leu Glu Thr Gly Gly Gln
              20                  25                  30        
 Val Tyr Ala Ile Gly Gly Cys Asp Asp Asn Gly Val Pro Met Asp Cys
          35                  40                  45            
 Phe Glu Val Tyr Ser Pro Glu Ala Asp Gln Trp Thr Ala Leu Pro Arg
      50                  55                  60                
 Leu Pro Thr Ala Arg Ala Gly Val Ala Val Thr Ala Leu Gly Lys Arg
  65                  70                  75                  80
 Ile Met Val Ile Gly Gly Val Gly Thr Asn Gln Leu Pro Leu Lys Val
                  85                  90                  95    
 Val Glu Met Tyr Asn Ile Asp Glu Gly Lys Trp Lys Lys Arg Ser Met
             100                 105                 110        
 Leu Arg Glu Ala Ala Met Gly Ile Ser Val Thr Ala Lys Asp Tyr Arg
         115                 120                 125            
 Val Tyr Ala Ala Gly Gly Met Gly Leu Asp Leu Arg Pro His Asn His
     130                 135                 140                
 Leu Gln His Tyr Asp Met Leu Lys Asp Met Trp Val Ser Leu Ala Pro
 145                 150                 155                 160
 Met Pro Thr Pro Arg Tyr Ala Ala Thr Ser Phe Leu Arg Gly Ser Lys
                 165                 170                 175    
 Ile Tyr Val Leu Gly Gly Arg Gln Ser Lys Tyr Ala Val Asn Ala Phe
             180                 185                 190        
 Glu Val Phe Asp Ile Glu Thr Arg Ser Trp Thr Lys Phe Pro Asn Ile
         195                 200                 205            
 Pro Tyr Lys Arg Ala Phe Ser Ser Phe Val Thr Leu Asp Asn His Leu
     210                 215                 220                
 Tyr Ser Leu Gly Gly Leu Arg Gln Gly Arg Leu Tyr Arg Gln Pro Lys
 225                 230                 235                 240
 Phe Leu Arg Thr Met Asp Val Phe Asp Met Glu Gln Gly Gly Trp Leu
                 245                 250                 255    
 Lys Met Glu Arg Ser Phe Phe Leu Lys Lys Arg Arg Ala Asp Phe Val
             260                 265                 270        
 Ala Gly Ser Leu Ser Gly Arg Val Ile Val Ala Gly Gly Leu Gly Asn
         275                 280                 285            
 Gln Pro Thr Val Leu Glu Thr Ala Glu Ala Phe His Pro Gly Lys Asn
     290                 295                 300                
 Lys Trp Glu Ile Leu Pro Ala Met Pro Thr Pro Arg Cys Ala Cys Ser
 305                 310                 315                 320
 Ser Ile Val Val Lys Asn Cys Leu Leu Ala Val Gly Gly Val Asn Gln
                 325                 330                 335    
 Gly Leu Ser Asp Ala Val Glu Ala Leu Cys Val Ser Asp Ser
             340                 345                 350



      <210> 753
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 753
 Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys
   1               5                  10                  15    
 Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Thr Ala Gly Lys Thr Thr
              20                  25                  30        
 Ile Leu Tyr Lys Leu Lys Leu Gly Glu Thr Val Pro Ala Val Pro Thr
          35                  40                  45            
 Val Gly Phe Cys Val Glu Thr Val Glu Tyr Lys Asn Asn Thr Phe Ala
      50                  55                  60                
 Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His
  65                  70                  75                  80
 Phe Phe Gln Asn Thr Lys Glu Leu Ser Ala Ser Gln Phe Ala Gln Phe
                  85                  90                  95    
 Ile Lys Lys Leu Cys Gly Val Thr Gly Thr Asn Asp Glu Ala Ser Pro
             100                 105                 110        
 Gly Lys Leu Asn Phe Leu Ser Ile Pro Ser Leu Gly Gln Met Met Pro
         115                 120                 125            
 Val Asn Tyr Phe Glu
     130            



      <210> 754
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 754
 Met Ala Arg Asp Pro Pro Asn Arg Val Pro Pro Thr Thr Glu Gly Thr
   1               5                  10                  15    
 Arg Gly Leu Leu Ser Cys Leu Pro Asp Val Glu Arg Ala Thr Leu Thr
              20                  25                  30        
 Leu Leu Leu Asp His Leu Arg Leu Val Ser Ser Phe His Ala Tyr Asn
          35                  40                  45            
 Arg Met Thr Pro Gln Asn Leu Ala Val Cys Phe Gly Pro Val Leu Leu
      50                  55                  60                
 Pro Ala Arg Gln Ala Pro Thr Arg Pro Arg Ala Arg Ser Ser Gly Pro
  65                  70                  75                  80
 Gly Leu Ala Ser Ala Val Asp Phe Lys His His Ile Glu Val Leu His
                  85                  90                  95    
 Tyr Leu Leu Gln Ser Trp Pro Gly Glu Phe Met Pro Arg Ala Cys Thr
             100                 105                 110        
 Thr Asn Leu Ser Gln Pro Ala Cys Pro Asp Asn Leu Arg Thr Ser Arg
         115                 120                 125            
 Leu Thr Cys Asp Pro Asn Asp Ser His Leu Cys Thr Cys Arg Trp Gln
     130                 135                 140                
 Thr Pro Lys Trp Val Thr Arg Pro Arg Gly Arg Gly Gly Pro Glu Ser
 145                 150                 155                 160
 Pro Pro Ser Asn Arg Tyr Ala Gly Asp Trp Ser Val Cys Gly Arg Asp
                 165                 170                 175    
 Phe Leu Pro Cys Gly Arg Asp Phe Leu Ser Gly Pro Asp Tyr Asp His
             180                 185                 190        
 Val Thr Gly Ser Asp Ser Glu Asp Glu Asp Glu Glu Val Gly Glu Pro
         195                 200                 205            
 Arg Val Thr Gly Asp Phe Glu Asp Asp Phe Asp Ala Pro Phe Asn Pro
     210                 215                 220                
 His Leu Asn Leu Lys Asp Phe Asp Ala Leu Ile Leu Asp Leu Glu Arg
 225                 230                 235                 240
 Glu Leu Ser Lys Gln Ile Asn Val Cys Leu
                 245                 250



      <210> 755
      <211> 415
      <212> PRT
      <213> Homo sapiens


      <400> 755
 Met Val Tyr Thr Val Leu Gln His Arg Asp Tyr His Asn Thr Ser Met
   1               5                  10                  15    
 Ala Leu Glu Gly Val Pro Glu Leu Leu Gln Lys Ile Leu Glu Ala Pro
              20                  25                  30        
 Asp Phe Tyr Val Gln Met Lys Trp Glu Phe Thr Ser Trp Val Pro Leu
          35                  40                  45            
 Val Ser Arg Ile Cys Pro Asn Asp Val Cys Arg Ile Trp Lys Ser Gly
      50                  55                  60                
 Ala Lys Leu Arg Val Asp Ile Thr Leu Leu Gly Phe Glu Asn Met Ser
  65                  70                  75                  80
 Trp Ile Arg Gly Arg Arg Ser Phe Ile Phe Lys Gly Glu Asp Asn Trp
                  85                  90                  95    
 Ala Glu Leu Met Glu Val Asn His Asp Asp Lys Val Val Thr Thr Glu
             100                 105                 110        
 Arg Phe Asp Leu Ser Gln Glu Met Glu Arg Leu Thr Leu Asp Leu Met
         115                 120                 125            
 Lys Pro Lys Ser Arg Glu Val Glu Arg Arg Leu Thr Ser Pro Val Ile
     130                 135                 140                
 Asn Thr Ser Leu Asp Thr Lys Asn Ile Ala Phe Glu Arg Thr Lys Ser
 145                 150                 155                 160
 Gly Phe Trp Gly Trp Arg Thr Asp Lys Ala Glu Val Val Asn Gly Tyr
                 165                 170                 175    
 Glu Ala Lys Val Tyr Thr Val Asn Asn Val Asn Val Ile Thr Lys Ile
             180                 185                 190        
 Arg Thr Glu His Leu Thr Glu Glu Glu Lys Lys Arg Tyr Lys Ala Asp
         195                 200                 205            
 Arg Asn Pro Leu Glu Ser Leu Leu Gly Thr Val Glu His Gln Phe Gly
     210                 215                 220                
 Ala Gln Gly Asp Leu Thr Thr Glu Cys Ala Thr Ala Asn Asn Pro Thr
 225                 230                 235                 240
 Ala Ile Thr Pro Asp Glu Tyr Phe Asn Glu Glu Phe Asp Leu Lys Asp
                 245                 250                 255    
 Arg Asp Ile Gly Arg Pro Lys Glu Leu Thr Ile Arg Thr Gln Lys Phe
             260                 265                 270        
 Lys Ala Met Leu Trp Met Cys Glu Glu Phe Pro Leu Ser Leu Val Glu
         275                 280                 285            
 Gln Val Ile Pro Ile Ile Asp Leu Met Ala Arg Thr Ser Ala His Phe
     290                 295                 300                
 Ala Arg Leu Arg Asp Phe Ile Lys Leu Glu Phe Pro Pro Gly Phe Pro
 305                 310                 315                 320
 Val Lys Ile Glu Ile Pro Leu Phe His Val Leu Asn Ala Arg Ile Thr
                 325                 330                 335    
 Phe Gly Asn Val Asn Gly Cys Ser Thr Ala Glu Glu Ser Val Ser Gln
             340                 345                 350        
 Asn Val Glu Gly Thr Gln Ala Asp Ser Ala Ser His Ile Thr Asn Phe
         355                 360                 365            
 Glu Val Asp Gln Ser Val Phe Glu Ile Pro Glu Ser Tyr Tyr Val Gln
     370                 375                 380                
 Asp Asn Gly Arg Asn Val His Leu Gln Asp Glu Asp Tyr Glu Ile Met
 385                 390                 395                 400
 Gln Phe Ala Ile Gln Gln Val Leu Gln Leu Ser Leu Thr Asp Lys
                 405                 410                 415



      <210> 756
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 756
 Met Ser Gly Arg Ala Gly Arg Arg Gly Gln Asp Leu Met Gly Asp Val
   1               5                  10                  15    
 Tyr Phe Phe Asp Ile Pro Phe Pro Lys Ile Gly Lys Leu Ile Lys Ser
              20                  25                  30        
 Asn Val Pro Glu Leu Arg Gly His Phe Pro Leu Ser Ile Thr Leu Val
          35                  40                  45            
 Leu Arg Leu Met Leu Leu Ala Ser Lys Gly Asp Asp Pro Glu Asp Ala
      50                  55                  60                
 Lys Ala Lys Val Leu Ser Val Leu Lys His Ser Leu Leu Ser Phe Lys
  65                  70                  75                  80
 Gln Pro Arg Val Met Asp Met Leu Lys Leu Tyr Phe Leu Phe Ser Leu
                  85                  90                  95    
 Gln Phe Leu Val Lys Glu Gly Tyr Leu Asp Gln Glu Gly Asn Pro Met
             100                 105                 110        
 Gly Phe Ala Gly Leu Val Ser His Leu His Tyr His Glu Pro Ser Asn
         115                 120                 125            
 Leu Val Phe Val Ser Phe Leu Val Asn Gly Leu Phe His Asp Leu Cys
     130                 135                 140                
 Gln Pro Thr Arg Lys Gly Ser Lys His Phe Ser Gln Asp Val Met Glu
 145                 150                 155                 160
 Lys Leu Val Leu Val Leu Ala His Leu Phe Gly Arg Arg Tyr Phe Pro
                 165                 170                 175    
 Pro Lys Phe Gln Asp Ala His Phe Glu Phe Tyr Gln Ser Lys Val Phe
             180                 185                 190        
 Leu Asp Asp Leu Pro Glu Asp Phe Ser Asp Ala Leu Asp Glu Tyr Asn
         195                 200                 205            
 Met Lys Ile Met Glu Asp Phe Thr Thr Phe Leu Arg Ile Val Ser Lys
     210                 215                 220                
 Leu Ala Asp Met Asn Gln Glu Tyr Gln Leu Pro Leu Ser Lys Ile Lys
 225                 230                 235                 240
 Phe Thr Gly Lys Glu Cys Glu Asp Ser Gln Leu Val Ser His Leu Met
                 245                 250                 255    
 Ser Cys Lys Glu Gly Arg Val Ala Ile Ser Pro Phe Val Cys Leu Ser
             260                 265                 270        
 Gly Asn Phe Asp Asp Asp Leu Leu Arg Leu Glu Thr Pro Asn His Val
         275                 280                 285            
 Thr Leu Gly Thr Ile Gly Val Asn Arg Ser Gln Ala Pro Val Leu Leu
     290                 295                 300                
 Ser Gln Lys Phe Asp Asn Arg Gly Arg Lys Met Ser Leu Asn Ala Tyr
 305                 310                 315                 320
 Ala Leu Asp Phe Tyr Lys His Gly Ser Leu Ile Gly Leu Val Gln Asp
                 325                 330                 335    
 Asn Arg Met Asn Glu Gly Asp Ala Tyr Tyr Leu Leu Lys Asp Phe Ala
             340                 345                 350        
 Leu Thr Ile Lys Ser Ile Ser Val Ser Leu Arg Glu Leu Cys Glu Asn
         355                 360                 365            
 Glu Asp Asp Asn Val Val Leu Ala Phe Glu Gln Leu Ser Thr Thr Phe
     370                 375                 380                
 Trp Glu Lys Leu Asn Lys Val
 385                 390    



      <210> 757
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 757
 Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys
   1               5                  10                  15    
 Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Thr Ala Gly Lys Thr Thr
              20                  25                  30        
 Ile Leu Tyr Lys Leu Lys Leu Gly Glu Thr Val Pro Ala Val Pro Thr
          35                  40                  45            
 Val Gly Phe Cys Val Glu Thr Val Glu Tyr Lys Asn Asn Thr Phe Ala
      50                  55                  60                
 Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His
  65                  70                  75                  80
 Phe Phe Gln Asn Thr Lys Glu Leu Ser Ala Ser Gln Phe Ala Gln Phe
                  85                  90                  95    
 Ile Lys Lys Leu Cys Gly Val Thr Gly Thr Asn Asp Glu Ala Ser Pro
             100                 105                 110        
 Gly Lys Leu Asn Phe Leu Ser Ile Pro Ser Leu Gly Gln Met Met Pro
         115                 120                 125            
 Val Asn Tyr Phe Glu Cys Ser Ser Thr Lys Pro Arg Pro Asp Ser Cys
     130                 135                 140                
 Asn His Arg Met Ala Thr Pro Pro Leu Lys His Arg Thr Ser Gly Phe
 145                 150                 155                 160
 Ala Ser Glu Val Ala Pro Trp Ser Leu His Phe Pro Phe Leu Gln Gly
                 165                 170                 175    
 Gln Lys Thr Glu Ala Val Arg Ser Phe Ser Val Lys Phe Leu Pro Arg
             180                 185                 190        
 Met Leu Ile Arg Leu Gln Thr Val Leu Phe
         195                 200        



      <210> 758
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 758
 Met Met Ala Thr Pro Asn Gln Thr Ala Cys Asn Ala Glu Ser Pro Val
   1               5                  10                  15    
 Ala Leu Glu Glu Ala Lys Thr Ser Gly Ala Pro Gly Ser Pro Gln Thr
              20                  25                  30        
 Pro Pro Glu Arg His Asp Ser Gly Gly Ser Leu Pro Leu Thr Pro Arg
          35                  40                  45            
 Met Glu Ser His Ser Glu Asp Glu Asp Leu Ala Gly Ala Val Gly Gly
      50                  55                  60                
 Leu Gly Trp Asn Ser Arg Ser Pro Arg Thr Gln Ser Pro Gly Gly Cys
  65                  70                  75                  80
 Ser Ala Glu Ala Val Leu Ala Arg Lys Lys His Arg Arg Arg Pro Ser
                  85                  90                  95    
 Lys Arg Lys Arg His Trp Arg Pro Tyr Leu Glu Leu Ser Trp Ala Glu
             100                 105                 110        
 Lys Gln Gln Arg Asp Glu Arg Gln Ser Gln Arg Ala Ser Arg Val Arg
         115                 120                 125            
 Glu Glu Met Phe Ala Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr
     130                 135                 140                
 Gln Phe Leu Met Asn Asp Arg Asp Pro Glu Glu Pro Asn Leu Asp Val
 145                 150                 155                 160
 Pro His Gly Ile Ser His Pro Gly Ser Ser Gly Glu Ser Glu Ala Gly
                 165                 170                 175    
 Asp Ser Asp Gly Arg Gly Arg Ala His Gly Glu Phe Gln Arg Lys Asp
             180                 185                 190        
 Phe Ser Glu Thr Tyr Glu Arg Phe His Thr Glu Ser Leu Gln Gly Arg
         195                 200                 205            
 Ser Lys Gln Glu Leu Val Arg Asp Tyr Leu Glu Leu Glu Lys Arg Leu
     210                 215                 220                
 Ser Gln Ala Glu Glu Glu Thr Arg Arg Leu Gln Gln Leu Gln Ala Cys
 225                 230                 235                 240
 Thr Gly Gln Gln Ser Cys Arg Gln Val Glu Glu Leu Ala Ala Glu Val
                 245                 250                 255    
 Gln Arg Leu Arg Thr Glu Asn Gln Arg Leu Arg Gln Glu Asn Gln Met
             260                 265                 270        
 Trp Asn Arg Glu Gly Cys Arg Cys Asp Glu Glu Pro Gly Thr
         275                 280                 285    



      <210> 759
      <211> 304
      <212> PRT
      <213> Homo sapiens


      <400> 759
 Met Ala Ser Ser Ala Ser Leu Glu Thr Met Val Pro Pro Ala Cys Pro
   1               5                  10                  15    
 Arg Ala Gly Ala Leu Pro Ala Thr Ser Lys Thr Leu Ala Phe Ser Ile
              20                  25                  30        
 Glu Arg Ile Met Ala Lys Thr Ser Glu Pro Arg Ala Pro Phe Glu Pro
          35                  40                  45            
 Arg Pro Gly Ala Leu Glu Ala Asp Gly Ser Gln Gly Lys Lys Leu Leu
      50                  55                  60                
 Asn Leu Cys Ser Pro Leu Pro Cys Met Ile Pro Leu Gln Pro Leu Gly
  65                  70                  75                  80
 Tyr Glu Val Pro Ser Lys Thr Leu Leu Ser Tyr Ser Glu Leu Trp Lys
                  85                  90                  95    
 Ser Ser Leu Arg Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
             100                 105                 110        
 Gly Gly Gly Gly Gly Ala Pro Val Cys Gly Ala Ser Gly Leu Cys Lys
         115                 120                 125            
 Thr Asn Cys Gly Val Cys Cys Lys Ala Glu Leu Gly Leu Ala Pro Ser
     130                 135                 140                
 Ala Leu Pro Ala Gly Arg Val Ile Lys Pro Gln Val Ile Asn Gln Ala
 145                 150                 155                 160
 Val Gly Leu Pro Ala Ser Gly Ser Leu Tyr Tyr Phe Asn Tyr Leu Asp
                 165                 170                 175    
 Ser Thr Ala Tyr Pro Pro Ser Glu Leu Leu Ser Gly His Leu Phe Pro
             180                 185                 190        
 Ser Gly Leu Leu Asn Ala Gln Ala Pro Ala Ala Leu Ala Ala His Pro
         195                 200                 205            
 Lys Leu Phe Leu Leu Glu Asn Ala Lys Leu Ala Gly Leu Ala Ala Asp
     210                 215                 220                
 Lys Phe Pro His Pro Ala Pro Tyr Pro His Lys Glu Arg Leu Pro Ala
 225                 230                 235                 240
 Pro Leu Glu Gln Val Leu Lys Glu Asn Ser Ala Leu Thr Ala Glu Arg
                 245                 250                 255    
 Gly Gly Val Lys Gly His Ser Lys Leu Pro Gly Gly Ser Ala Asp Gly
             260                 265                 270        
 Lys Pro Lys Asn Phe Thr Cys Glu Val Cys Gly Lys Val Phe Asn Ala
         275                 280                 285            
 His Tyr Asn Leu Thr Arg His Leu Arg Gln Arg Val Leu Gln Lys Leu
     290                 295                 300                





      <210> 760
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 760
 Met Met Ala Ala Asp Ile Pro Arg Val Thr Thr Pro Leu Ser Ser Leu
   1               5                  10                  15    
 Val Gln Val Pro Gln Glu Glu Asp Arg Gln Glu Glu Glu Val Thr Thr
              20                  25                  30        
 Met Ile Leu Glu Asp Asp Ser Trp Val Gln Glu Ala Val Leu Gln Glu
          35                  40                  45            
 Asp Gly Pro Glu Ser Glu Pro Phe Pro Gln Ser Ala Gly Lys Gly Gly
      50                  55                  60                
 Pro Gln Glu Glu Val Thr Arg Gly Pro Gln Gly Ala Leu Gly Arg Leu
  65                  70                  75                  80
 Arg Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu Val His Thr Lys Glu
                  85                  90                  95    
 Gln Met Leu Thr Met Leu Pro Lys Glu Ile Gln Ala Trp Leu Gln Glu
             100                 105                 110        
 His Arg Pro Glu Ser Ser Glu Glu Ala Ala Ala Leu Val Glu Asp Leu
         115                 120                 125            
 Thr Gln Thr Leu Gln Asp Ser Ala Val Ala Val Phe Ala Ser Leu Pro
     130                 135                 140                
 Val Glu Val Thr Ser Leu
 145                 150



      <210> 761
      <211> 533
      <212> PRT
      <213> Homo sapiens


      <400> 761
 Met Phe Ser Leu Lys Pro Pro Lys Pro Thr Phe Arg Ser Tyr Leu Leu
   1               5                  10                  15    
 Pro Pro Pro Gln Thr Asp Asp Lys Ile Asn Ser Glu Pro Lys Ile Lys
              20                  25                  30        
 Lys Leu Glu Pro Val Leu Leu Pro Gly Glu Ile Val Val Asn Glu Val
          35                  40                  45            
 Asn Phe Val Arg Lys Cys Ile Ala Thr Asp Thr Ser Gln Tyr Asp Leu
      50                  55                  60                
 Trp Gly Lys Leu Ile Cys Ser Asn Phe Lys Ile Ser Phe Ile Thr Asp
  65                  70                  75                  80
 Asp Pro Met Pro Leu Gln Lys Phe His Tyr Arg Asn Leu Leu Leu Gly
                  85                  90                  95    
 Glu His Asp Val Pro Leu Thr Cys Ile Glu Gln Ile Val Thr Val Asn
             100                 105                 110        
 Asp His Lys Arg Lys Gln Lys Val Leu Gly Pro Asn Gln Lys Leu Lys
         115                 120                 125            
 Phe Asn Pro Thr Glu Leu Ile Ile Tyr Cys Lys Asp Phe Arg Ile Val
     130                 135                 140                
 Arg Phe Arg Phe Asp Glu Ser Gly Pro Glu Ser Ala Lys Lys Val Cys
 145                 150                 155                 160
 Leu Ala Ile Ala His Tyr Ser Gln Pro Thr Asp Leu Gln Leu Leu Phe
                 165                 170                 175    
 Ala Phe Glu Tyr Val Gly Lys Lys Tyr His Asn Ser Ala Asn Lys Ile
             180                 185                 190        
 Asn Gly Ile Pro Ser Gly Asp Gly Gly Gly Gly Gly Gly Gly Gly Asn
         195                 200                 205            
 Gly Ala Gly Gly Gly Ser Ser Gln Lys Thr Pro Leu Phe Glu Thr Tyr
     210                 215                 220                
 Ser Asp Trp Asp Arg Glu Ile Lys Arg Thr Gly Ala Ser Gly Trp Arg
 225                 230                 235                 240
 Val Cys Ser Ile Asn Glu Gly Tyr Met Ile Ser Thr Cys Leu Pro Glu
                 245                 250                 255    
 Tyr Ile Val Val Pro Ser Ser Leu Ala Asp Gln Asp Leu Lys Ile Phe
             260                 265                 270        
 Ser His Ser Phe Val Gly Arg Arg Met Pro Leu Trp Cys Trp Ser His
         275                 280                 285            
 Ser Asn Gly Ser Ala Leu Val Arg Met Ala Leu Ile Lys Asp Val Leu
     290                 295                 300                
 Gln Gln Arg Lys Ile Asp Gln Arg Ile Cys Asn Ala Ile Thr Lys Ser
 305                 310                 315                 320
 His Pro Gln Arg Ser Asp Val Tyr Lys Ser Asp Leu Asp Lys Thr Leu
                 325                 330                 335    
 Pro Asn Ile Gln Glu Val Gln Ala Ala Phe Val Lys Leu Lys Gln Leu
             340                 345                 350        
 Cys Val Asn Glu Pro Phe Glu Glu Thr Glu Glu Lys Trp Leu Ser Ser
         355                 360                 365            
 Leu Glu Asn Thr Arg Trp Leu Glu Tyr Val Arg Ala Phe Leu Lys His
     370                 375                 380                
 Ser Ala Glu Leu Val Tyr Met Leu Glu Ser Lys His Leu Ser Val Val
 385                 390                 395                 400
 Leu Gln Glu Glu Glu Gly Arg Asp Leu Ser Cys Cys Val Ala Ser Leu
                 405                 410                 415    
 Val Gln Val Met Leu Asp Pro Tyr Phe Arg Thr Ile Thr Gly Phe Gln
             420                 425                 430        
 Ser Leu Ile Gln Lys Glu Trp Val Met Ala Gly Tyr Gln Phe Leu Asp
         435                 440                 445            
 Arg Cys Asn His Leu Lys Arg Ser Glu Lys Glu Ser Pro Leu Phe Leu
     450                 455                 460                
 Leu Phe Leu Asp Ala Thr Trp Gln Leu Leu Glu Gln Tyr Pro Ala Ala
 465                 470                 475                 480
 Phe Glu Phe Ser Glu Thr Tyr Leu Ala Val Leu Tyr Asp Ser Thr Arg
                 485                 490                 495    
 Ile Ser Leu Phe Gly Thr Phe Leu Phe Asn Ser Pro His Gln Arg Val
             500                 505                 510        
 Lys Gln Ser Thr Val Ser Arg Ile Lys Ser Cys Thr Lys Gln Asp Tyr
         515                 520                 525            
 Phe Pro Ser Arg Val
     530            



      <210> 762
      <211> 1741
      <212> PRT
      <213> Homo sapiens


      <400> 762
 Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg Asn Leu Glu Glu
   1               5                  10                  15    
 Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His Phe Thr Pro Val
              20                  25                  30        
 Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu Cys Gly Phe Gly
          35                  40                  45            
 Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg Ala Ser Cys Val
      50                  55                  60                
 Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro Val Cys Gly Ser
  65                  70                  75                  80
 Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln Arg Ala Gln Cys
                  85                  90                  95    
 Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly Pro Cys Gly Ser
             100                 105                 110        
 Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly Ser Thr Cys Ala
         115                 120                 125            
 Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys Pro Ala Thr Cys
     130                 135                 140                
 Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp Gly Ala Asp Tyr
 145                 150                 155                 160
 Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala Arg Gln Glu Asn
                 165                 170                 175    
 Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys Gln Gly Ala Leu
             180                 185                 190        
 Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg Thr Arg Arg Pro
         195                 200                 205            
 Glu Met Arg Leu Arg Pro Glu Ser Cys Pro Ala Arg Gln Ala Pro Val
     210                 215                 220                
 Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys Val Met Gly Arg
 225                 230                 235                 240
 Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val Arg Ser Gly Gln
                 245                 250                 255    
 Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg Phe Asn Ala Val
             260                 265                 270        
 Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys Asp Arg Val Thr
         275                 280                 285            
 Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp Gly Arg Thr Tyr
     290                 295                 300                
 Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala
 305                 310                 315                 320
 Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala Pro Ser Pro Cys
                 325                 330                 335    
 Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala Val Lys Asn Gly
             340                 345                 350        
 Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser Leu Tyr Asp Pro
         355                 360                 365            
 Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu Leu Glu
     370                 375                 380                
 Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val Ala Arg Lys Gly
 385                 390                 395                 400
 Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala Leu Cys Glu Ala
                 405                 410                 415    
 Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val Ala Leu Ala Gln
             420                 425                 430        
 Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser Glu Cys Met Leu
         435                 440                 445            
 His Val His Ala Cys Thr His Gln Ile Ser Leu His Val Ala Ser Ala
     450                 455                 460                
 Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala Phe Gly Ala Val
 465                 470                 475                 480
 Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu His Pro Pro Pro
                 485                 490                 495    
 Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu
             500                 505                 510        
 Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile Glu Glu Ala Arg
         515                 520                 525            
 Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly Gly Ser Gly Ser
     530                 535                 540                
 Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg Gln Arg Gly Gly
 545                 550                 555                 560
 Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val Cys Asp Phe Ser
                 565                 570                 575    
 Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser Asp Gly Val Thr
             580                 585                 590        
 Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys Glu Ser Gln Arg
         595                 600                 605            
 Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly Pro Thr Phe Ala
     610                 615                 620                
 Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln Thr Pro Tyr Gly
 625                 630                 635                 640
 Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val Gly Leu Ala Gly
                 645                 650                 655    
 Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser Tyr Gly Gly Thr
             660                 665                 670        
 Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro Gly Val Gly Gly
         675                 680                 685            
 Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn Phe Arg Gly Ile
     690                 695                 700                
 Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser Cys Asp Pro Gln
 705                 710                 715                 720
 Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly Leu Cys Ser Cys
                 725                 730                 735    
 Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys Pro Asp Gly Arg
             740                 745                 750        
 Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser Ala Pro Ala Thr
         755                 760                 765            
 Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys Val Glu Glu Ser
     770                 775                 780                
 Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys Pro Glu Ala Asn
 785                 790                 795                 800
 Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Asn Glu Cys
                 805                 810                 815    
 Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln Ile Ser Ile Gln
             820                 825                 830        
 Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser Thr His Pro Thr
         835                 840                 845            
 Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu Leu Ser Gln Ala
     850                 855                 860                
 Leu Pro Ala Pro Pro Gly Ala Leu Pro Leu Ala Pro Ser Ser Thr Ala
 865                 870                 875                 880
 His Ser Gln Thr Thr Pro Pro Pro Ser Ser Arg Pro Arg Thr Thr Ala
                 885                 890                 895    
 Ser Val Pro Arg Thr Thr Val Trp Pro Val Leu Thr Val Pro Pro Thr
             900                 905                 910        
 Ala Pro Ser Pro Ala Pro Ser Leu Val Ala Ser Ala Phe Gly Glu Ser
         915                 920                 925            
 Gly Ser Thr Asp Gly Ser Ser Asp Glu Glu Leu Ser Gly Asp Gln Glu
     930                 935                 940                
 Ala Ser Gly Gly Gly Ser Gly Gly Leu Glu Pro Leu Glu Gly Ser Ser
 945                 950                 955                 960
 Val Ala Thr Pro Gly Pro Pro Val Glu Arg Ala Ser Cys Tyr Asn Ser
                 965                 970                 975    
 Ala Leu Gly Cys Cys Ser Asp Gly Lys Thr Pro Ser Leu Asp Ala Glu
             980                 985                 990        
 Gly Ser Asn Cys Pro Ala Thr Lys Val Phe Gln Gly Val Leu Glu Leu
         995                1000                1005            
 Glu Gly Val Glu Gly Gln Glu Leu Phe Tyr Thr Pro Glu Met Ala Asp
    1010                1015                1020                
 Pro Lys Ser Glu Leu Phe Gly Glu Thr Ala Arg Ser Ile Glu Ser Thr
1025                1030                1035                1040
 Leu Asp Asp Leu Phe Arg Asn Ser Asp Val Lys Lys Asp Phe Arg Ser
                1045                1050                1055    
 Val Arg Leu Arg Asp Leu Gly Pro Gly Lys Ser Val Arg Ala Ile Val
            1060                1065                1070        
 Asp Val His Phe Asp Pro Thr Thr Ala Phe Arg Ala Pro Asp Val Ala
        1075                1080                1085            
 Arg Ala Leu Leu Arg Gln Ile Gln Val Ser Arg Arg Arg Ser Leu Gly
    1090                1095                1100                
 Val Arg Arg Pro Leu Gln Glu His Val Arg Phe Met Asp Phe Asp Trp
1105                1110                1115                1120
 Phe Pro Ala Phe Ile Thr Gly Ala Thr Ser Gly Ala Ile Ala Ala Gly
                1125                1130                1135    
 Ala Thr Ala Arg Ala Thr Thr Ala Ser Arg Leu Pro Ser Ser Ala Val
            1140                1145                1150        
 Thr Pro Arg Ala Pro His Pro Ser His Thr Ser Gln Pro Val Ala Lys
        1155                1160                1165            
 Thr Thr Ala Ala Pro Thr Thr Arg Arg Pro Pro Thr Thr Ala Pro Ser
    1170                1175                1180                
 Arg Val Pro Gly Arg Arg Pro Pro Ala Pro Gln Gln Pro Pro Lys Pro
1185                1190                1195                1200
 Cys Asp Ser Gln Pro Cys Phe His Gly Gly Thr Cys Gln Asp Trp Ala
                1205                1210                1215    
 Leu Gly Gly Gly Phe Thr Cys Ser Cys Pro Ala Gly Arg Gly Gly Ala
            1220                1225                1230        
 Val Cys Glu Lys Val Leu Gly Ala Pro Val Pro Ala Phe Glu Gly Arg
        1235                1240                1245            
 Ser Phe Leu Ala Phe Pro Thr Leu Arg Ala Tyr His Thr Leu Arg Leu
    1250                1255                1260                
 Ala Leu Glu Phe Arg Ala Leu Glu Pro Gln Gly Leu Leu Leu Tyr Asn
1265                1270                1275                1280
 Gly Asn Ala Arg Gly Lys Asp Phe Leu Ala Leu Ala Leu Leu Asp Gly
                1285                1290                1295    
 Arg Val Gln Leu Arg Phe Asp Thr Gly Ser Gly Pro Ala Val Leu Thr
            1300                1305                1310        
 Ser Ala Val Pro Val Glu Pro Gly Gln Trp His Arg Leu Glu Leu Ser
        1315                1320                1325            
 Arg His Trp Arg Arg Gly Thr Leu Ser Val Asp Gly Glu Thr Pro Val
    1330                1335                1340                
 Leu Gly Glu Ser Pro Ser Gly Thr Asp Gly Leu Asn Leu Asp Thr Asp
1345                1350                1355                1360
 Leu Phe Val Gly Gly Val Pro Glu Asp Gln Ala Ala Val Ala Leu Glu
                1365                1370                1375    
 Arg Thr Phe Val Gly Ala Gly Leu Arg Gly Cys Ile Arg Leu Leu Asp
            1380                1385                1390        
 Val Asn Asn Gln Arg Leu Glu Leu Gly Ile Gly Pro Gly Ala Ala Thr
        1395                1400                1405            
 Arg Gly Ser Gly Val Gly Glu Cys Gly Asp His Pro Cys Leu Pro Asn
    1410                1415                1420                
 Pro Cys His Gly Gly Ala Pro Cys Gln Asn Leu Glu Ala Gly Arg Phe
1425                1430                1435                1440
 His Cys Gln Cys Pro Pro Gly Arg Val Gly Pro Thr Cys Ala Asp Glu
                1445                1450                1455    
 Lys Ser Pro Cys Gln Pro Asn Pro Cys His Gly Ala Ala Pro Cys Arg
            1460                1465                1470        
 Val Leu Pro Glu Gly Gly Ala Gln Cys Glu Cys Pro Leu Gly Arg Glu
        1475                1480                1485            
 Gly Thr Phe Cys Gln Thr Ala Ser Gly Gln Asp Gly Ser Gly Pro Phe
    1490                1495                1500                
 Leu Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu Arg Gly Leu His
1505                1510                1515                1520
 Thr Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Val Arg Val
                1525                1530                1535    
 Pro Gly Thr Arg Pro Gln Arg Pro Pro Ala Leu Gln Arg Ala Glu Asp
            1540                1545                1550        
 Gly Arg Gln Gly Gly Leu Arg Val Ala Gly Thr Ala Gly Pro Pro Pro
        1555                1560                1565            
 Gly Val Pro Leu Arg Pro Gly Gln Gly Gly Ser Gly His Gln Glu Gln
    1570                1575                1580                
 Gly Ala Ser His Pro Gly Ser Leu Asp Gln Gly Leu Thr Gly Ala Lys
1585                1590                1595                1600
 Arg Pro Gln Gly Cys Pro Ala Cys Gly Arg Arg Pro Pro Cys Val Gly
                1605                1610                1615    
 Gly Val Pro Glu Ile Pro Gln Gly Ser Ala His Arg Pro Gln Pro Glu
            1620                1625                1630        
 Gly Ala Ala Leu Arg Arg Gly Arg Ser Arg Leu Gln Gln Ala Gly Pro
        1635                1640                1645            
 Cys Cys Cys Arg Val Leu Trp Leu Arg Arg Cys His Pro Ala Gly Leu
    1650                1655                1660                
 Pro Arg Arg Pro Pro Ala Ala Asp Pro Gly Ala Arg Ala Ala Ala Gly
1665                1670                1675                1680
 Gly Arg His Val Leu Cys Arg Ser Pro Leu His Pro Gly Leu Arg Pro
                1685                1690                1695    
 Pro Leu Pro Gln Trp Gly Leu Leu Arg Pro Glu Gly Gly Cys Leu Cys
            1700                1705                1710        
 Val Pro Val Ser Arg Gly Ile Leu Arg Thr Ala Leu Arg Glu Gly Ala
        1715                1720                1725            
 Gly Gly Glu Val Ser Gly Gly Arg Gly Tyr Leu Gly Leu
    1730                1735                1740    



      <210> 763
      <211> 349
      <212> PRT
      <213> Homo sapiens


      <400> 763
 Met Leu Asn Gln Thr Ser Gly Arg Thr Ser Leu Leu Pro Glu Leu Gly
   1               5                  10                  15    
 Val Val Thr Pro Ala Gln Gly Pro Arg Arg Arg Val Trp Cys Gly His
              20                  25                  30        
 Ser Lys Ala Lys Ala Arg Lys Ser Tyr Cys Ala Arg Ala Met Arg Gln
          35                  40                  45            
 Pro Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly
      50                  55                  60                
 Ala Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His
  65                  70                  75                  80
 Val Leu Asn Arg Val Pro Leu Arg His Val Leu Arg Leu Gln Arg Val
                  85                  90                  95    
 Thr Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg
             100                 105                 110        
 Arg Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu
         115                 120                 125            
 Ala Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala
     130                 135                 140                
 Pro Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala
 145                 150                 155                 160
 Arg Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu
                 165                 170                 175    
 Ser Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln
             180                 185                 190        
 Arg Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg
         195                 200                 205            
 Gly Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala
     210                 215                 220                
 Cys Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg
 225                 230                 235                 240
 Gly Ala Gly Leu Arg Ser Leu Ser Leu Ala Val Asn Ala Asn Val Gly
                 245                 250                 255    
 Asp Ala Ala Val Gln Glu Leu Ala Arg Asn Cys Pro Glu Leu His His
             260                 265                 270        
 Leu Asp Leu Thr Gly Cys Leu Arg Val Gly Ser Asp Gly Val Arg Thr
         275                 280                 285            
 Leu Ala Glu Tyr Cys Pro Val Leu Arg Ser Leu Arg Val Arg His Cys
     290                 295                 300                
 His His Val Ala Glu Ser Ser Leu Ser Arg Leu Arg Lys Arg Gly Val
 305                 310                 315                 320
 Asp Ile Asp Val Glu Pro Pro Leu His Gln Ala Leu Val Leu Leu Gln
                 325                 330                 335    
 Asp Met Ala Gly Phe Ala Pro Phe Val Asn Leu Gln Val
             340                 345                



      <210> 764
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 764
 Met Ala Pro Pro Ala Ala Pro Gly Arg Asp Arg Val Gly Arg Glu Asp
   1               5                  10                  15    
 Glu Asp Gly Trp Glu Thr Arg Gly Asp Arg Lys Ala Arg Lys Pro Leu
              20                  25                  30        
 Val Glu Lys Lys Arg Arg Ala Arg Ile Asn Glu Ser Leu Gln Glu Leu
          35                  40                  45            
 Arg Leu Leu Leu Ala Gly Ala Glu Val Gln Ala Lys Leu Glu Asn Ala
      50                  55                  60                
 Glu Val Leu Glu Leu Thr Val Arg Arg Val Gln Gly Val Leu Arg Gly
  65                  70                  75                  80
 Arg Ala Arg Glu Arg Glu Gln Leu Gln Ala Glu Ala Ser Glu Arg Phe
                  85                  90                  95    
 Ala Ala Gly Tyr Ile Gln Cys Met His Glu Val His Thr Phe Val Ser
             100                 105                 110        
 Thr Cys Gln Ala Ile Asp Ala Thr Val Ala Ala Glu Leu Leu Asn His
         115                 120                 125            
 Leu Leu Glu Ser Met Pro Leu Arg Glu Gly Ser Ser Phe Gln Asp Leu
     130                 135                 140                
 Leu Gly Asp Ala Leu Ala Gly Pro Pro Arg Ala Pro Gly Arg Ser Gly
 145                 150                 155                 160
 Trp Pro Ala Gly Gly Ala Pro Gly Ser Pro Ile Pro Ser Pro Pro Gly
                 165                 170                 175    
 Pro Gly Asp Asp Leu Cys Ser Asp Leu Glu Glu Ala Pro Glu Ala Glu
             180                 185                 190        
 Leu Ser Gln Ala Pro Ala Glu Gly Pro Asp Leu Val Pro Ala Ala Leu
         195                 200                 205            
 Gly Ser Leu Thr Thr Ala Gln Ile Ala Arg Ser Val Trp Arg Pro Trp
     210                 215                 220                





      <210> 765
      <211> 717
      <212> PRT
      <213> Homo sapiens


      <400> 765
 Met Glu Gly Ala His Ala Ser Leu Ser Leu Glu Asp Glu Val Ser Gly
   1               5                  10                  15    
 Ala Gly Ser Arg Gln Arg Pro Leu Glu Gly Lys Gly Gly Glu Thr Pro
              20                  25                  30        
 Ala Ala Glu Glu Pro Gly Ser Leu Lys Asn Tyr Ala Val Phe Ala Thr
          35                  40                  45            
 Arg Asp Val Ser Ala Ala Pro Glu Lys Glu Glu Glu Glu Ala Glu Gly
      50                  55                  60                
 Pro Leu Arg Ala Gln Asp Leu Arg Glu Ser Tyr Ile Gln Leu Val Gln
  65                  70                  75                  80
 Gly Val Gln Glu Trp Gln Asp Gly Cys Met Tyr Gln Gly Glu Phe Gly
                  85                  90                  95    
 Leu Asn Met Lys Leu Gly Tyr Gly Lys Phe Ser Trp Pro Thr Gly Glu
             100                 105                 110        
 Ser Tyr His Gly Gln Phe Tyr Arg Asp His Cys His Gly Leu Gly Thr
         115                 120                 125            
 Tyr Met Trp Pro Asp Gly Ser Ser Phe Thr Gly Thr Phe Tyr Leu Ser
     130                 135                 140                
 His Arg Glu Gly Tyr Gly Thr Met Tyr Met Lys Thr Arg Leu Phe Gln
 145                 150                 155                 160
 Thr His Cys His Asn Asp Ile Val Asn Leu Leu Leu Asp Cys Gly Ala
                 165                 170                 175    
 Asp Val Asn Lys Cys Ser Asp Glu Gly Leu Thr Ala Leu Ser Met Cys
             180                 185                 190        
 Phe Leu Leu His Tyr Pro Ala Gln Ser Phe Lys Pro Asn Val Ala Glu
         195                 200                 205            
 Arg Thr Ile Pro Glu Pro Gln Glu Pro Pro Lys Phe Pro Val Val Pro
     210                 215                 220                
 Ile Leu Ser Ser Ser Phe Met Asp Thr Asn Leu Glu Ser Leu Tyr Tyr
 225                 230                 235                 240
 Glu Val Asn Val Pro Ser Gln Gly Ser Tyr Glu Leu Arg Pro Leu Pro
                 245                 250                 255    
 Ala Pro Leu Leu Leu Pro Arg Val Ser Gly Ser His Glu Gly Gly His
             260                 265                 270        
 Phe Gln Asp Thr Gly Gln Cys Gly Gly Ser Ile Asp His Arg Ser Ser
         275                 280                 285            
 Ser Leu Lys Gly Asp Ser Pro Leu Val Lys Gly Ser Leu Gly His Val
     290                 295                 300                
 Glu Ser Gly Leu Glu Asp Val Leu Gly Asn Thr Asp Arg Gly Ser Leu
 305                 310                 315                 320
 Cys Ser Ala Glu Thr Lys Phe Glu Ser Asn Val Cys Val Cys Asp Phe
                 325                 330                 335    
 Ser Ile Glu Leu Ser Gln Ala Met Leu Glu Arg Ser Ala Gln Ser His
             340                 345                 350        
 Ser Leu Leu Lys Met Ala Ser Pro Ser Pro Cys Thr Ser Ser Phe Asp
         355                 360                 365            
 Lys Gly Thr Met Arg Arg Met Ala Leu Ser Met Ile Glu Arg Arg Lys
     370                 375                 380                
 Arg Trp Arg Thr Ile Glu Leu Leu Leu Arg Arg Gly Ala Asp Pro Asn
 385                 390                 395                 400
 Leu Cys Cys Val Pro Met Gln Val Leu Phe Leu Ala Val Lys Ala Gly
                 405                 410                 415    
 Asp Val Asp Gly Val Arg Leu Leu Leu Glu His Gly Ala Arg Thr Asp
             420                 425                 430        
 Ile Cys Phe Pro Pro Gln Leu Ser Thr Leu Thr Pro Leu His Ile Ala
         435                 440                 445            
 Ala Ala Leu Pro Gly Glu Glu Gly Val Gln Ile Val Glu Leu Leu Leu
     450                 455                 460                
 His Ala Ile Thr Asp Val Asp Ala Lys Ala Ser Asp Glu Asp Asp Thr
 465                 470                 475                 480
 Tyr Lys Pro Gly Lys Val Val Lys Glu Leu Leu Thr Gln Gly Ala Asp
                 485                 490                 495    
 Pro Asn Leu Pro Leu Thr Lys Gly Leu Gly Ser Ala Leu Cys Val Ala
             500                 505                 510        
 Cys Asp Leu Thr Tyr Glu His Gln Arg Asn Met Asp Ser Lys Leu Ala
         515                 520                 525            
 Leu Ile Asp Arg Leu Ile Ser His Gly Ala Asp Ile Leu Lys Pro Val
     530                 535                 540                
 Met Leu Arg Gln Gly Glu Lys Glu Ala Val Gly Thr Ala Val Asp Tyr
 545                 550                 555                 560
 Gly Tyr Phe Arg Phe Phe Gln Asp Arg Arg Ile Ala Arg Cys Pro Phe
                 565                 570                 575    
 His Thr Leu Met Pro Ala Glu Arg Glu Thr Phe Leu Ala Arg Lys Arg
             580                 585                 590        
 Leu Leu Glu Tyr Met Gly Leu Gln Leu Arg Gln Ala Val Phe Ala Lys
         595                 600                 605            
 Glu Ser Gln Trp Asp Pro Thr Trp Leu Tyr Leu Cys Lys Arg Ala Glu
     610                 615                 620                
 Leu Ile Pro Ser His Arg Met Lys Lys Lys Gly Pro Ser Leu Pro Arg
 625                 630                 635                 640
 Gly Leu Asp Val Lys Glu Gln Gly Gln Ile Pro Phe Phe Lys Phe Cys
                 645                 650                 655    
 Tyr Gln Cys Gly Arg Ser Ile Gly Val Arg Leu Leu Pro Cys Pro Arg
             660                 665                 670        
 Cys Tyr Gly Ile Leu Thr Cys Ser Lys Tyr Cys Lys Thr Lys Ala Trp
         675                 680                 685            
 Thr Glu Phe His Lys Lys Asp Cys Gly Asp Leu Val Ala Ile Val Thr
     690                 695                 700                
 Gln Leu Glu Gln Val Ser Arg Arg Arg Glu Glu Phe Gln
 705                 710                 715        



      <210> 766
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 766
 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ser Leu Ala Val
   1               5                  10                  15    
 Ser Ser Asp Ser His Leu His Thr Pro Met Cys Phe Phe Leu Ser Asn
              20                  25                  30        
 Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys Met
          35                  40                  45            
 Ile Val Asp Met Arg Ser His Ser Gly Val Ile Ser Tyr Ala Asp Cys
      50                  55                  60                
 Leu Thr Arg Met Ser Phe Leu Val Leu Phe Ala Cys Val Glu Asp Met
  65                  70                  75                  80
 Leu Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg Pro
                  85                  90                  95    
 Leu His Tyr Pro Val Ile Val Asn Pro His Leu Cys Val Phe Leu Val
             100                 105                 110        
 Ser Val Ser Phe Ser Leu Ala Cys Trp Ile Pro Ser Cys Ala Val Gly
         115                 120                 125            
 Leu Cys Cys Asn Ser Pro Ser Ser Arg Met Trp Lys Ser Leu Ile Leu
     130                 135                 140                
 Ser Val Thr His Leu Asn Leu Ser Ser Leu Pro Val Leu Thr Ala Ser
 145                 150                 155                 160
 Ser Ile Ala Cys Ser Tyr Ile Ser Ile Val Leu Cys Leu Val Phe Phe
                 165                 170                 175    
 Ala Phe Gln Gly Ser Phe Cys Leu Thr Ile Lys Leu Ser Pro Pro Phe
             180                 185                 190        





      <210> 767
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 767
 Met Leu Gly Gln Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg
   1               5                  10                  15    
 Ser His Tyr Glu Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu
              20                  25                  30        
 Asn Lys Trp Ser Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala
          35                  40                  45            
 Phe Ala Thr Pro Phe Leu Val Val Arg His Gln Leu Leu Lys Thr Ser
      50                  55                  60                
 Gly Cys Phe Ser Ser Ser Leu Ser Pro Ile
  65                  70                



      <210> 768
      <211> 498
      <212> PRT
      <213> Homo sapiens


      <400> 768
 Met Leu Val Ser Leu Leu Lys Lys Lys Arg Asn Asp Asn Ser Glu Pro
   1               5                  10                  15    
 Gln Leu Ala His Leu Ile Pro Glu Leu Cys Phe Leu Thr Gly Leu Thr
              20                  25                  30        
 Asp Gln Ala Thr Ser Asp Phe Gln Leu Met Lys Ala Val Ala Glu Lys
          35                  40                  45            
 Thr Arg Leu Ser Pro Ser Gly Arg Gln Gln Arg Leu Ala Arg Leu Val
      50                  55                  60                
 Asp Asn Ile Gln Arg Asn Thr Asn Ala Arg Phe Glu Leu Glu Thr Trp
  65                  70                  75                  80
 Gly Leu His Phe Gly Ser Gln Ile Ser Leu Thr Gly Arg Ile Val Pro
                  85                  90                  95    
 Ser Glu Lys Ile Leu Met Gln Asp His Ile Cys Gln Pro Val Ser Ala
             100                 105                 110        
 Ala Asp Trp Ser Lys Asp Ile Arg Thr Cys Lys Ile Leu Asn Ala Gln
         115                 120                 125            
 Ser Leu Asn Thr Trp Leu Ile Leu Cys Ser Asp Arg Thr Glu Tyr Val
     130                 135                 140                
 Ala Glu Ser Phe Leu Asn Cys Leu Arg Arg Val Ala Gly Ser Met Gly
 145                 150                 155                 160
 Phe Asn Val Asp Tyr Pro Lys Ile Ile Lys Val Gln Glu Asn Pro Ala
                 165                 170                 175    
 Ala Phe Val Arg Ala Ile Gln Gln Tyr Val Asp Pro Asp Val Gln Leu
             180                 185                 190        
 Val Met Cys Ile Leu Pro Ser Asn Gln Lys Thr Tyr Tyr Asp Ser Ile
         195                 200                 205            
 Lys Lys Tyr Leu Ser Ser Asp Cys Pro Val Pro Ser Gln Cys Val Leu
     210                 215                 220                
 Ala Arg Thr Leu Asn Lys Gln Gly Met Met Met Ser Ile Ala Thr Lys
 225                 230                 235                 240
 Ile Ala Met Gln Met Thr Cys Lys Leu Gly Gly Glu Leu Trp Ala Val
                 245                 250                 255    
 Glu Ile Pro Leu Lys Ser Leu Met Val Val Gly Ile Asp Val Cys Lys
             260                 265                 270        
 Asp Ala Leu Ser Lys Asp Val Met Val Val Gly Cys Val Ala Ser Val
         275                 280                 285            
 Asn Pro Arg Ile Thr Arg Trp Phe Ser Arg Cys Ile Leu Gln Arg Thr
     290                 295                 300                
 Met Thr Asp Val Ala Asp Cys Leu Lys Val Phe Met Thr Gly Ala Leu
 305                 310                 315                 320
 Asn Lys Trp Tyr Lys Tyr Asn His Asp Leu Pro Ala Arg Ile Ile Val
                 325                 330                 335    
 Tyr Arg Ala Gly Val Gly Asp Gly Gln Leu Lys Thr Leu Ile Glu Tyr
             340                 345                 350        
 Glu Val Pro Gln Leu Leu Ser Ser Val Ala Glu Ser Ser Ser Asn Thr
         355                 360                 365            
 Ser Ser Arg Leu Ser Val Ile Val Val Arg Lys Lys Cys Met Pro Arg
     370                 375                 380                
 Phe Phe Thr Glu Met Asn Arg Thr Val Gln Asn Pro Pro Leu Gly Thr
 385                 390                 395                 400
 Val Val Asp Ser Glu Ala Thr Arg Asn Glu Trp Tyr Asp Phe Tyr Leu
                 405                 410                 415    
 Ile Ser Gln Val Ala Cys Arg Gly Thr Val Ser Pro Thr Tyr Tyr Asn
             420                 425                 430        
 Val Ile Tyr Asp Asp Asn Gly Leu Lys Pro Asp His Met Gln Arg Leu
         435                 440                 445            
 Thr Phe Lys Leu Cys His Leu Tyr Tyr Asn Trp Pro Gly Ile Val Ser
     450                 455                 460                
 Val Pro Ala Pro Cys Gln Tyr Ala His Lys Leu Thr Phe Leu Gly Ala
 465                 470                 475                 480
 Gln Ser Ile His Lys Glu Pro Ser Leu Glu Leu Ala Asn His Leu Phe
                 485                 490                 495    
 Tyr Leu
        



      <210> 769
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 769
 Met Met Ser Pro Gly Leu Leu Leu Lys Pro Trp Trp Gly Gly Ala Gln
   1               5                  10                  15    
 Ser Glu Met Gly Arg Asn Gly Met Leu Glu Gly Cys Ser Val Met Ser
              20                  25                  30        
 Val Gly Ala Ser Arg Leu Gly Glu Gly Arg Val Arg Pro Arg Ala His
          35                  40                  45            
 Ser Arg Arg Pro Val Thr Arg Pro Arg Trp Arg Ala Ala Gly Pro Cys
      50                  55                  60                
 Thr Gly Thr Cys Gln Gly Gly Ser His Ser Arg Thr Leu Val Leu Arg
  65                  70                  75                  80
 Leu Lys Ala Val Ser Thr Thr Pro Thr Ser Ala Asn Asp Leu Val Gln
                  85                  90                  95    
 Ile Lys Phe Arg Arg Asp Gly Gly Asn Arg Val Val Glu Ala Leu Asn
             100                 105                 110        
 Leu Ser Glu Lys Arg Lys Asp Arg Lys Ala Gln Lys Gln Arg Asp Arg
         115                 120                 125            
 Arg Met Lys Lys Lys Lys Arg Glu Val Val Gly Thr Ala Ser Ser Arg
     130                 135                 140                
 Trp Arg Ser Ser Ala Leu Gly
 145                 150    



      <210> 770
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 770
 Met Ser Gly Ser Asp Gly Gly Leu Glu Glu Glu Pro Glu Leu Ser Ile
   1               5                  10                  15    
 Thr Leu Thr Leu Arg Met Leu Met His Gly Lys Glu Val Gly Ser Ile
              20                  25                  30        
 Ile Gly Lys Lys Gly Glu Thr Val Lys Arg Ile Arg Glu Gln Ser Ser
          35                  40                  45            
 Ala Arg Ile Thr Ile Ser Glu Gly Ser Cys Pro Glu Arg Ile Thr Thr
      50                  55                  60                
 Ile Thr Gly Ser Thr Ala Ala Val Phe His Ala Val Ser Met Ile Ala
  65                  70                  75                  80
 Phe Lys Leu Asp Glu Asp Leu Cys Ala Ala Pro Ala Asn Gly Gly Asn
                  85                  90                  95    
 Val Ser Arg Pro Pro Val Thr Leu Arg Leu Val Ile Pro Ala Ser Gln
             100                 105                 110        
 Cys Gly Ser Leu Ile Gly Lys Ala Gly Thr Lys Ile Lys Glu Ile Arg
         115                 120                 125            
 Glu Thr Thr Gly Ala Gln Val Gln Val Ala Gly Asp Leu Leu Pro Asn
     130                 135                 140                
 Ser Thr Glu Arg Ala Val Thr Val Ser Gly Val Pro Asp Ala Ile Ile
 145                 150                 155                 160
 Leu Cys Val Arg Gln Ile Cys Ala Val Ile Leu Glu Ser Pro Pro Lys
                 165                 170                 175    
 Gly Ala Thr Ile Pro Tyr His Pro Ser Leu Ser Leu Gly Thr Val Leu
             180                 185                 190        
 Leu Ser Ala Asn Gln Gly Phe Ser Val Gln Gly Gln Tyr Gly Ala Val
         195                 200                 205            
 Thr Pro Ala Glu Val Thr Lys Leu Gln Gln Leu Ser Ser His Ala Val
     210                 215                 220                
 Pro Phe Ala Thr Pro Ser Val Val Pro Gly Leu Asp Pro Gly Thr Gln
 225                 230                 235                 240
 Thr Ser Ser Gln Glu Phe Leu Val Pro Asn Asp Leu Ile Gly Cys Val
                 245                 250                 255    
 Ile Gly Arg Gln Gly Ser Lys Ile Ser Glu Ile Arg Gln Met Ser Gly
             260                 265                 270        
 Ala His Ile Lys Ile Gly Asn Gln Ala Glu Gly Ala Gly Glu Arg His
         275                 280                 285            
 Val Thr Ile Thr Gly Ser Pro Val Ser Ile Ala Leu Ala Gln Tyr Leu
     290                 295                 300                
 Ile Thr Ala Cys Leu Glu Thr Ala Lys Ser Thr Ser Gly Gly Thr Pro
 305                 310                 315                 320
 Ser Ser Ala Pro Ala Asp Leu Pro Ala Pro Phe Ser Pro Pro Leu Thr
                 325                 330                 335    
 Ala Leu Pro Thr Ala Pro Pro Gly Leu Leu Gly Thr Pro Tyr Ala Ile
             340                 345                 350        
 Ser Leu Ser Asn Phe Ile Gly Leu Lys Pro Met Pro Phe Leu Ala Leu
         355                 360                 365            
 Pro Pro Ala Ser Pro Gly Pro Pro Pro Gly Leu Ala Ala Tyr Thr Ala
     370                 375                 380                
 Lys Met Ala Ala Ala Asn Gly Ser Lys Lys Ala Glu Arg Gln Lys Phe
 385                 390                 395                 400
 Ser Pro Tyr
            



      <210> 771
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 771
 Met Pro Asp Tyr Ser Val His Ile Leu Ser Asp Val Gln Phe Val Lys
   1               5                  10                  15    
 Ile Thr Arg Gln Gln Tyr Gln Asn Ala Leu Thr Ala Cys His Met Asp
              20                  25                  30        
 Ser Ser Pro Gln Ser Pro Asp Met Glu Ala Phe Thr Asp Gly Asp Ser
          35                  40                  45            
 Thr Lys Ala Pro Thr Thr Arg Gly Thr Pro Gln Thr Pro Lys Asp Asp
      50                  55                  60                
 Pro Ala Ile Thr Leu Leu Asn Asn Arg Asn Ser Leu Pro Cys Ser Arg
  65                  70                  75                  80
 Ser Asp Gly Leu Arg Ser Pro Ser Glu Val Val Tyr Leu Arg Met Glu
                  85                  90                  95    
 Glu Leu Ala Phe Thr Gln Glu Glu Met Thr Asp Phe Glu Glu His Ser
             100                 105                 110        
 Thr Gln Gln Leu Thr Leu Ser Pro Ala Ala Val Pro Thr Arg Ala Ala
         115                 120                 125            
 Ser Asp Ser Glu Cys Cys Asn Ile Asn Leu Asp Thr Glu Thr Ser Pro
     130                 135                 140                
 Cys Ser Ser Asp Phe Glu Glu Asn Val Gly Lys Lys Leu Leu Arg Thr
 145                 150                 155                 160
 Leu Ser Gly Gln Lys Arg Lys Arg Ser Pro Glu Gly Glu Arg Thr Ser
                 165                 170                 175    
 Glu Asp Asn Ser Asn Leu Thr Pro Leu Ile Thr
             180                 185        



      <210> 772
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 772
 Met Val Gln Ala Gly Pro Ser Ser Cys Ser Ile Ser Gly Asp Pro Gly
   1               5                  10                  15    
 Leu Pro Arg Arg Trp Arg Pro Ala Gln Val Val Arg Pro Gly Arg Leu
              20                  25                  30        
 Arg Ile Arg Gly Trp Ser Arg Arg Ile Pro Lys Ala Glu Val Gly Ser
          35                  40                  45            
 Pro Gly Asp Ser Gln Leu Leu Ser Leu Trp Arg Arg Gly Pro Val Thr
      50                  55                  60                
 Glu Ala Pro Phe Ser Asn Pro Gly Ala Ala Phe Ser Pro Tyr Arg Lys
  65                  70                  75                  80
 Ser Asp Gly Leu Met Thr Ser Trp Leu Ala Ala Glu Arg
                  85                  90            



      <210> 773
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 773
 Met Asp Ser Gly Cys Ile Gly Ser Ala Val Leu Leu Met Ala Ala Ser
   1               5                  10                  15    
 His Thr Leu Gly Pro Val Pro Gly Thr Gln Gln Ala Leu Asp Ser Arg
              20                  25                  30        
 Lys Pro Ser His Ala Arg Gly Gly Pro Arg Leu Ser Gly Trp Glu Arg
          35                  40                  45            
 Ala Glu Pro Leu Ser Gly Ser Trp Leu Leu Leu Leu Arg Thr Pro Leu
      50                  55                  60                
 Ala Phe Ser Ser Leu Pro Ile Leu Ser Pro Ser Gln Pro Gly Leu Arg
  65                  70                  75                  80
 Thr Arg Leu Phe Pro Pro Phe Arg Ile Thr Leu Pro Asp Thr Ile Tyr
                  85                  90                  95    
 Val Phe Lys Lys Gln Thr His Leu Leu Asn Lys Arg Met Lys Gln Trp
             100                 105                 110        
 Met Arg Arg Gly Gly Asn Gln Ala Gly Trp His Arg His Gln Tyr Met
         115                 120                 125            
 Trp Trp Leu Leu Glu Gly Gly Arg Ala Arg Ala Ala Ala Gly His Ser
     130                 135                 140                
 Pro Gly Pro Cys Pro Pro Ser Ser Gln Gly Leu Ser Gly Leu Leu Gln
 145                 150                 155                 160
 Trp Val Pro Lys Gly Pro Ser Leu Pro Trp Ala Ser Gly His Leu Asp
                 165                 170                 175    
 Pro Gln Pro Thr Cys
             180    



      <210> 774
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 774
 Met Val Arg Gly Gly Val Met Val Arg Val Glu Ile Lys Val Arg Val
   1               5                  10                  15    
 Arg Ile Arg Asp Gln Asp Arg Asp Gln Asp Leu Gly Ser Val Ser Lys
              20                  25                  30        
 Ser Trp Asp Lys Val Arg Val Arg Ile Arg Thr Arg Ala Leu Phe Ser
          35                  40                  45            
 Ser Gly Pro Thr Arg Gly Trp Val Thr Met Ala Leu Glu Arg Leu Val
      50                  55                  60                
 Val Trp His Val His Ser Glu Asp Gln Ser Phe Ile Val Leu Lys Thr
  65                  70                  75                  80
 Asp Leu Gly Arg Cys Gly Cys Arg Pro Leu Arg Lys Val Arg Gln Gln
                  85                  90                  95    
 Leu Pro Val Cys Ser Pro Cys Ala Glu Glu Gly Ala Leu Pro Trp Ala
             100                 105                 110        
 Leu Leu Ser His Val Ile Phe His Lys Ser Cys Phe Thr Lys Ala Ser
         115                 120                 125            
 Leu Pro
     130



      <210> 775
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 775
 Met Asn His Pro Ala Leu Thr Val His Pro Ala His Gln Leu Gly Ala
   1               5                  10                  15    
 Ser Pro Leu Gln Pro Pro His Ser Phe Phe Gly Ala Gln His Arg Asp
              20                  25                  30        
 Pro Leu His Phe Tyr Pro Trp Val Leu Arg Asn Arg Phe Phe Gly His
          35                  40                  45            
 Arg Phe Gln Ala Ser Asp Val Pro Gln Asp Gly Leu Leu Leu His Gly
      50                  55                  60                
 Pro Phe Ala Arg Lys Pro Lys Arg Ile Arg Thr Ala Phe Ser Pro Ser
  65                  70                  75                  80
 Gln Leu Leu Arg Leu Glu Arg Ala Phe Glu Lys Asn His Tyr Val Val
                  85                  90                  95    
 Gly Ala Glu Arg Lys Gln Leu Ala Gly Ser Leu Ser Leu Ser Glu Thr
             100                 105                 110        
 Gln Val Lys Val Trp Phe Gln Asn Arg Arg Thr Lys Tyr Lys Arg Gln
         115                 120                 125            
 Lys Leu Glu Glu Glu Gly Pro Glu Ser Glu Gln Lys Lys Lys Gly Ser
     130                 135                 140                
 His His Ile Asn Arg Trp Arg Ile Ala Thr Lys Gln Ala Asn Gly Glu
 145                 150                 155                 160
 Asp Ile Asp Val Thr Ser Asn Asp
                 165            



      <210> 776
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 776
 Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Ser
   1               5                  10                  15    
 Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg
              20                  25                  30        
 Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr
          35                  40                  45            
 Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val
      50                  55                  60                
 Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val
  65                  70                  75                  80
 Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His
                  85                  90                  95    
 Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe
             100                 105                 110        
 Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp
         115                 120                 125            
 Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile
     130                 135                 140                
 Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys
 145                 150                 155                 160





      <210> 777
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 777
 Met Gln Gln Gln Pro Leu Pro Gly Pro Gly Ala Pro Thr Thr Glu Pro
   1               5                  10                  15    
 Thr Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Ala Met Ala Ile Gln
              20                  25                  30        
 Ser Ser Pro Gly Gln Arg Ala Thr Leu Ser Gly Ile Tyr Arg Tyr Ile
          35                  40                  45            
 Met Gly Arg Phe Ala Phe Tyr Arg His Asn Arg Pro Gly Trp Gln Asn
      50                  55                  60                
 Ser Ile Arg His Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro
  65                  70                  75                  80
 Arg Asp Asp Arg Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro
                  85                  90                  95    
 Asp Cys His Asp Met Phe Glu His Gly Ser Phe Leu Arg Arg Arg Arg
             100                 105                 110        
 Arg Phe Thr Arg Gln Thr Gly Ala Glu Gly Thr Arg Gly Pro Ala Lys
         115                 120                 125            
 Ala Arg Arg Gly Pro Leu Arg Ala Thr Ser Gln Asp Pro Gly Val Pro
     130                 135                 140                
 Asn Ala Thr Thr Gly Arg Gln Cys Ser Phe Pro Pro Glu Leu Pro Asp
 145                 150                 155                 160
 Pro Lys Gly Leu Ser Leu Gly Gly Ser Gly Gly Gly His Ala Ser Gln
                 165                 170                 175    
 Tyr Val Pro Ser Asn His
             180        



      <210> 778
      <211> 269
      <212> PRT
      <213> Homo sapiens


      <400> 778
 Met Lys Gln Thr Asn Ile Asn Leu Glu Ser Arg Leu Leu Lys Glu Glu
   1               5                  10                  15    
 Glu Leu Arg Lys Glu Glu Val Gln Thr Leu Gln Ala Glu Leu Ala Cys
              20                  25                  30        
 Arg Gln Thr Glu Val Lys Ala Leu Ser Thr Gln Val Glu Glu Leu Lys
          35                  40                  45            
 Asp Glu Leu Val Thr Gln Arg Arg Lys His Ala Ser Ser Ile Lys Asp
      50                  55                  60                
 Leu Thr Lys Gln Leu Gln Gln Ala Arg Arg Lys Leu Asp Gln Val Glu
  65                  70                  75                  80
 Ser Gly Ser Tyr Asp Lys Glu Val Ser Ser Met Gly Ser Arg Ser Ser
                  85                  90                  95    
 Ser Ser Gly Ser Leu Asn Ala Arg Ser Ser Ala Glu Asp Arg Ser Pro
             100                 105                 110        
 Glu Asn Thr Gly Ser Ser Val Ala Val Asp Asn Phe Pro Gln Val Asp
         115                 120                 125            
 Lys Ala Met Leu Ile Glu Arg Ile Val Arg Leu Gln Lys Ala His Ala
     130                 135                 140                
 Arg Lys Asn Glu Lys Ile Glu Phe Met Glu Asp His Ile Lys Gln Leu
 145                 150                 155                 160
 Val Glu Glu Ile Arg Lys Lys Thr Lys Ile Ile Gln Ser Tyr Ile Leu
                 165                 170                 175    
 Arg Glu Glu Ser Gly Thr Leu Ser Ser Glu Ala Ser Asp Phe Asn Lys
             180                 185                 190        
 Val His Leu Ser Arg Arg Gly Gly Ile Met Ala Ser Leu Tyr Thr Ser
         195                 200                 205            
 His Pro Ala Asp Asn Gly Leu Thr Leu Glu Leu Ser Leu Glu Ile Asn
     210                 215                 220                
 Arg Lys Leu Gln Ala Val Leu Glu Asp Thr Leu Leu Lys Asn Ile Thr
 225                 230                 235                 240
 Leu Lys Glu Asn Leu Gln Thr Leu Gly Thr Glu Ile Glu Arg Leu Ile
                 245                 250                 255    
 Lys His Gln His Glu Leu Glu Gln Arg Thr Lys Lys Thr
             260                 265                



      <210> 779
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 779
 Met Ser His Leu Pro Ala Val Ser Pro Val Phe Phe Gln Leu Pro Ala
   1               5                  10                  15    
 Pro His Pro Pro Thr Val Leu Arg Pro Gln Leu Gly Leu His Pro Asn
              20                  25                  30        
 Pro Glu Cys Asp Arg Glu Lys Met Ser Val Arg Asp His Asp Pro Glu
          35                  40                  45            
 Val Leu Thr Arg Asn Ser Gly Ser Leu Gln Ala
      50                  55                



      <210> 780
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 780
 Met Ser Lys Ser Ser Trp Ala Gly Asn Leu Pro Leu Cys Ser Arg Pro
   1               5                  10                  15    
 Ser Ser Lys Ala Gln Leu Ser Pro Cys Cys Ala Trp Gly Ser Gly Glu
              20                  25                  30        
 Phe His Ser Leu Met Glu Gly Arg Gly Pro Glu Cys Lys Leu Pro Gly
          35                  40                  45            
 Lys Ser Pro Met Leu Thr Cys Ala Gln Arg Ser Pro Pro Leu Thr Ser
      50                  55                  60                
 Gln Arg Pro Arg Thr Pro Ile Pro Asn Gln Ser Ser Ala Ser Ala Pro
  65                  70                  75                  80
 His Gly Ala Leu Pro His Phe Gln Gly Ala Gln Gln Pro Leu Thr Leu
                  85                  90                  95    
 Ala Leu Pro Trp Gln His Gly Thr Cys Gln Gln Leu Arg Val Ala Ala
             100                 105                 110        
 Val Cys Ala Gly Ile Cys Ala Arg Ile Trp Ala His Ser Leu Gln
         115                 120                 125        



      <210> 781
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 781
 Met Ser Leu His Glu Pro Thr Val Leu Ala Ala Trp His Ser Cys Ala
   1               5                  10                  15    
 Arg Arg Gly Ser Cys Ser Ser Pro Arg Ala Pro Gly Pro Asp Thr Trp
              20                  25                  30        
 Arg Val Pro Arg Trp Thr Arg Ser Ser Thr Cys Gly Pro Pro Ala Phe
          35                  40                  45            
 Leu Gly Val Phe Gly Arg Arg Ala Arg Thr Ser Ala Gly Val Gly Ala
      50                  55                  60                
 Trp Gly Ala Ala Ala Val Gly Arg Thr Ala Gly Val Arg Thr Trp Ala
  65                  70                  75                  80
 Pro Leu Ala Met Ala Ala Lys Val Asp Leu Ser Thr Ser Thr Asp Trp
                  85                  90                  95    
 Lys Glu Ala Lys Ser Phe Leu Lys Gly Leu Ser Asp Lys Gln Arg Glu
             100                 105                 110        
 Glu His Tyr Phe Cys Lys Asp Phe Val Arg Leu Lys Lys Ile Pro Thr
         115                 120                 125            
 Trp Lys Glu Met Ala Lys Gly Val Ala Val Lys Val Glu Glu Pro Arg
     130                 135                 140                
 Tyr Lys Lys Asp Lys Gln Leu Asn Glu Lys Ile Ser Leu Leu Arg Ser
 145                 150                 155                 160
 Asp Ile Thr Lys Leu Glu Val Asp Ala Ile Val Asn Ala Ala Asn Ser
                 165                 170                 175    
 Ser Leu Leu Gly Gly Gly Gly Val Asp Gly Cys Ile His Arg Ala Ala
             180                 185                 190        
 Gly Pro Leu Leu Thr Asp Glu Cys Arg Thr Leu Gln Ser Cys Lys Thr
         195                 200                 205            
 Gly Lys Ala Lys Ile Thr Gly Gly Tyr Arg Leu Pro Ala Lys Tyr Val
     210                 215                 220                
 Ile His Thr Val Gly Pro Ile Ala Tyr Gly Glu Pro Ser Ala Ser Gln
 225                 230                 235                 240
 Ala Ala Glu Leu Arg Ser Cys Tyr Leu Ser Ser Leu Asp Leu Leu Leu
                 245                 250                 255    
 Glu His Arg Leu Arg Ser Val Ala Phe Pro Cys Ile Ser Thr Gly Val
             260                 265                 270        
 Phe Gly Tyr Pro Cys Glu Ala Ala Ala Glu Ile Val Leu Ala Thr Leu
         275                 280                 285            
 Arg Glu Trp Leu Glu Gln His Lys Asp Lys Val Asp Arg Leu Ile Ile
     290                 295                 300                
 Cys Val Phe Leu Glu Lys Asp Glu Asp Ile Tyr Arg Ser Arg Leu Pro
 305                 310                 315                 320
 His Tyr Phe Pro Val Ala
                 325    



      <210> 782
      <211> 428
      <212> PRT
      <213> Homo sapiens


      <400> 782
 Met Ser Leu Ile Gln Lys Glu Ala Gln Gly Gln Ser Gly Thr Asp Gln
   1               5                  10                  15    
 Thr Val Val Val Leu Ser Asn Pro Thr Tyr Tyr Met Ser Asn Asp Ile
              20                  25                  30        
 Pro Tyr Thr Phe His Gln Asp Asn Asn Phe Leu Tyr Leu Cys Gly Phe
          35                  40                  45            
 Gln Glu Pro Asp Ser Ile Leu Val Leu Gln Ser Leu Pro Gly Lys Gln
      50                  55                  60                
 Leu Pro Ser His Lys Ala Ile Leu Phe Val Pro Arg Arg Asp Pro Ser
  65                  70                  75                  80
 Arg Glu Leu Trp Asp Gly Pro Arg Ser Gly Thr Asp Gly Ala Ile Ala
                  85                  90                  95    
 Leu Thr Gly Val Asp Glu Ala Tyr Thr Leu Glu Glu Phe Gln His Leu
             100                 105                 110        
 Leu Pro Lys Met Lys Ala Glu Thr Asn Met Val Trp Tyr Asp Trp Met
         115                 120                 125            
 Arg Pro Ser His Ala Gln Leu His Ser Asp Tyr Met Gln Pro Leu Thr
     130                 135                 140                
 Glu Ala Lys Ala Lys Ser Lys Asn Lys Val Arg Gly Val Gln Gln Leu
 145                 150                 155                 160
 Ile Gln Arg Leu Arg Leu Ile Lys Ser Pro Ala Glu Ile Glu Arg Met
                 165                 170                 175    
 Gln Ile Ala Gly Lys Leu Thr Ser Gln Ala Phe Ile Glu Thr Met Phe
             180                 185                 190        
 Thr Ser Lys Ala Pro Val Glu Glu Ala Phe Leu Tyr Ala Lys Phe Glu
         195                 200                 205            
 Phe Glu Cys Arg Ala Arg Gly Ala Asp Ile Leu Ala Tyr Pro Pro Val
     210                 215                 220                
 Val Ala Gly Gly Asn Arg Ser Asn Thr Leu His Tyr Val Lys Asn Asn
 225                 230                 235                 240
 Gln Leu Ile Lys Asp Gly Glu Met Val Leu Leu Asp Gly Gly Cys Glu
                 245                 250                 255    
 Ser Ser Cys Tyr Val Ser Asp Ile Thr Arg Thr Trp Pro Val Asn Gly
             260                 265                 270        
 Arg Phe Thr Ala Pro Gln Ala Glu Leu Tyr Glu Ala Val Leu Glu Ile
         275                 280                 285            
 Gln Arg Asp Cys Leu Ala Leu Cys Phe Pro Gly Thr Ser Leu Glu Asn
     290                 295                 300                
 Ile Tyr Ser Met Met Leu Thr Leu Ile Gly Gln Lys Leu Lys Asp Leu
 305                 310                 315                 320
 Gly Ile Met Lys Asn Ile Lys Glu Asn Asn Ala Phe Lys Ala Ala Arg
                 325                 330                 335    
 Lys Tyr Cys Pro His His Val Gly His Tyr Leu Gly Met Asp Val His
             340                 345                 350        
 Asp Thr Pro Asp Met Pro Arg Ser Leu Pro Leu Gln Pro Gly Met Val
         355                 360                 365            
 Ile Thr Ile Glu Pro Gly Ile Tyr Ile Pro Glu Asp Asp Lys Asp Ala
     370                 375                 380                
 Pro Glu Lys Phe Arg Gly Leu Gly Val Arg Ile Glu Asp Asp Val Val
 385                 390                 395                 400
 Val Thr Gln Asp Ser Pro Leu Ile Leu Ser Ala Asp Cys Pro Lys Glu
                 405                 410                 415    
 Met Asn Asp Ile Glu Gln Ile Cys Ser Gln Ala Ser
             420                 425            



      <210> 783
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 783
 Met Cys Gln Gly Gly Asp Phe Ile Arg His Asn Gly Thr Gly Gly Lys
   1               5                  10                  15    
 Ser Ile Tyr Gly Glu Lys Phe Asp Asp Glu Asn Phe Ile Leu Lys His
              20                  25                  30        
 Thr Gly Pro Gly Met Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn
          35                  40                  45            
 Gly Ser Gln Phe Leu Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly
      50                  55                  60                
 Lys Leu Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu
  65                  70                  75                  80
 Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile
                  85                  90                  95    
 Thr Ile Ala Asp Cys Gly Gln Leu Glu
             100                 105



      <210> 784
      <211> 534
      <212> PRT
      <213> Homo sapiens


      <400> 784
 Met Ile Ala Arg Gln Gln Cys Val Arg Gly Gly Pro Arg Gly Phe Ser
   1               5                  10                  15    
 Cys Gly Ser Ala Ile Val Gly Gly Gly Lys Arg Gly Ala Phe Ser Ser
              20                  25                  30        
 Val Ser Met Ser Gly Gly Ala Gly Arg Cys Ser Ser Gly Gly Phe Gly
          35                  40                  45            
 Ser Arg Ser Leu Tyr Asn Leu Arg Gly Asn Lys Ser Ile Ser Met Ser
      50                  55                  60                
 Val Ala Gly Ser Arg Gln Gly Ala Cys Phe Gly Gly Ala Gly Gly Phe
  65                  70                  75                  80
 Gly Thr Gly Gly Phe Gly Ala Gly Gly Phe Gly Ala Gly Phe Gly Thr
                  85                  90                  95    
 Gly Gly Phe Gly Gly Gly Phe Gly Gly Ser Phe Ser Gly Lys Gly Gly
             100                 105                 110        
 Pro Gly Phe Pro Val Cys Pro Ala Gly Gly Ile Gln Glu Val Thr Ile
         115                 120                 125            
 Asn Gln Ser Leu Leu Thr Pro Leu His Val Glu Ile Asp Pro Glu Ile
     130                 135                 140                
 Gln Lys Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Leu Leu Asn Asn
 145                 150                 155                 160
 Lys Phe Ala Ser Phe Ile Asp Lys Val Gln Phe Leu Glu Gln Gln Asn
                 165                 170                 175    
 Lys Val Leu Glu Thr Lys Trp Asn Leu Leu Gln Gln Gln Thr Thr Thr
             180                 185                 190        
 Thr Ser Ser Lys Asn Leu Glu Pro Leu Phe Glu Thr Tyr Leu Ser Val
         195                 200                 205            
 Leu Arg Lys Gln Leu Asp Thr Leu Gly Asn Asp Lys Gly Arg Leu Gln
     210                 215                 220                
 Ser Glu Leu Lys Thr Met Gln Asp Ser Val Glu Asp Phe Lys Thr Lys
 225                 230                 235                 240
 Tyr Glu Glu Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe Val
                 245                 250                 255    
 Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Leu Asn Lys Val Glu Leu
             260                 265                 270        
 Glu Ala Lys Val Asp Ser Leu Asn Asp Glu Ile Asn Phe Leu Lys Val
         275                 280                 285            
 Leu Tyr Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp Thr
     290                 295                 300                
 Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser
 305                 310                 315                 320
 Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser
                 325                 330                 335    
 Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys Val Gln Gln Leu Gln
             340                 345                 350        
 Ile Ser Val Asp Gln His Gly Asp Asn Leu Lys Asn Thr Lys Ser Glu
         355                 360                 365            
 Ile Ala Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Glu
     370                 375                 380                
 Asn Ile Lys Lys Gln Cys Gln Thr Leu Gln Val Ser Val Ala Asp Ala
 385                 390                 395                 400
 Glu Gln Arg Gly Glu Asn Ala Leu Lys Asp Ala His Ser Lys Arg Val
                 405                 410                 415    
 Glu Leu Glu Ala Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala Arg Met
             420                 425                 430        
 Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala Leu Asp Ile
         435                 440                 445            
 Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Tyr Arg Met
     450                 455                 460                
 Ser Gly Glu Cys Gln Ser Ala Val Ser Ile Ser Val Val Ser Gly Ser
 465                 470                 475                 480
 Thr Ser Thr Gly Gly Ile Ser Gly Gly Leu Gly Ser Gly Ser Gly Phe
                 485                 490                 495    
 Gly Leu Ser Ser Gly Phe Gly Ser Gly Ser Gly Ser Gly Phe Gly Phe
             500                 505                 510        
 Gly Gly Ser Val Ser Gly Ser Ser Ser Ser Lys Ile Ile Ser Thr Thr
         515                 520                 525            
 Thr Leu Asn Lys Arg Arg
     530                



      <210> 785
      <211> 459
      <212> PRT
      <213> Homo sapiens


      <400> 785
 Met Thr Ala Thr Ser Phe Gln Thr Thr Thr Thr Tyr Pro Thr Pro Ser
   1               5                  10                  15    
 His Pro Gln Thr Thr Leu Pro Thr His Val Pro Pro Phe Ser Thr Ser
              20                  25                  30        
 Leu Val Thr Pro Ser Thr His Thr Val Ile Ile Thr Thr His Thr Gln
          35                  40                  45            
 Met Ala Thr Ser Ala Ser Ile His Ser Thr Pro Thr Gly Thr Val Pro
      50                  55                  60                
 Pro Pro Thr Thr Leu Lys Ala Thr Gly Ser Thr His Thr Ala Pro Pro
  65                  70                  75                  80
 Met Thr Val Thr Thr Ser Gly Thr Ser Gln Thr His Ser Ser Phe Ser
                  85                  90                  95    
 Thr Ala Thr Ala Ser Ser Ser Phe Ile Ser Ser Ser Ser Trp Ser Ser
             100                 105                 110        
 Trp Leu Pro Gln Asn Ser Ser Ser Arg Pro Pro Ser Ser Pro Ile Thr
         115                 120                 125            
 Thr Gln Leu Pro His Leu Ser Ser Ala Thr Thr Pro Val Ser Thr Thr
     130                 135                 140                
 Asn Gln Leu Ser Ser Ser Phe Ser Pro Ser Pro Ser Ala Pro Ser Thr
 145                 150                 155                 160
 Val Ser Ser Tyr Val Pro Ser Ser His Ser Ser Pro Gln Thr Ser Ser
                 165                 170                 175    
 Pro Ser Val Gly Thr Ser Ser Ser Phe Val Ser Ala Pro Val His Ser
             180                 185                 190        
 Thr Thr Leu Ser Ser Gly Ser His Ser Ser Leu Ser Thr His Pro Thr
         195                 200                 205            
 Thr Gly Ser Gly Ser Ala Ser Pro Leu Phe Pro Ser Ser Pro Ala Ala
     210                 215                 220                
 Ser Thr Thr Ile Arg Ala Thr Leu Pro His Thr Ile Ser Ser Pro Phe
 225                 230                 235                 240
 Thr Leu Ser Ala Leu Leu Pro Ile Ser Thr Val Thr Val Ser Pro Thr
                 245                 250                 255    
 Pro Ser Ser His Leu Ala Ser Ser Thr Ile Ala Phe Pro Ser Thr Pro
             260                 265                 270        
 Arg Thr Thr Ala Ser Thr His Thr Ala Pro Ala Phe Ser Ser Gln Ser
         275                 280                 285            
 Thr Thr Ser Arg Ser Thr Ser Leu Thr Thr Arg Val Pro Thr Ser Gly
     290                 295                 300                
 Phe Val Ser Leu Thr Ser Gly Val Thr Gly Ile Pro Thr Ser Pro Val
 305                 310                 315                 320
 Thr Asn Leu Thr Thr Arg His Pro Gly Pro Thr Leu Ser Pro Thr Thr
                 325                 330                 335    
 Arg Phe Leu Thr Ser Ser Leu Thr Ala His Gly Ser Thr Pro Ala Ser
             340                 345                 350        
 Ala Pro Val Ser Ser Leu Gly Thr Pro Thr Pro Thr Ser Pro Gly Val
         355                 360                 365            
 Cys Ser Val Arg Glu Gln Gln Glu Glu Ile Thr Phe Lys Gly Cys Met
     370                 375                 380                
 Ala Asn Val Thr Val Thr Arg Cys Glu Gly Ala Cys Ile Ser Ala Ala
 385                 390                 395                 400
 Ser Phe Asn Ile Ile Thr Gln Gln Val Asp Ala Arg Cys Ser Cys Cys
                 405                 410                 415    
 Arg Pro Leu His Ser Tyr Glu Gln Gln Leu Glu Leu Pro Cys Pro Asp
             420                 425                 430        
 Pro Ser Thr Pro Gly Arg Arg Leu Val Leu Thr Leu Gln Val Phe Ser
         435                 440                 445            
 His Cys Val Cys Ser Ser Val Ala Cys Gly Asp
     450                 455                



      <210> 786
      <211> 423
      <212> PRT
      <213> Homo sapiens


      <400> 786
 Met Met Tyr Arg Pro Asp Val Val Arg Ala Arg Lys Arg Val Cys Trp
   1               5                  10                  15    
 Glu Pro Trp Val Ile Gly Leu Val Ile Phe Ile Ser Leu Ile Val Leu
              20                  25                  30        
 Ala Val Cys Ile Gly Leu Thr Val His Tyr Val Arg Tyr Asn Gln Lys
          35                  40                  45            
 Lys Thr Tyr Asn Tyr Tyr Ser Thr Leu Ser Phe Thr Thr Asp Lys Leu
      50                  55                  60                
 Tyr Ala Glu Phe Gly Arg Glu Ala Ser Asn Asn Phe Thr Glu Met Ser
  65                  70                  75                  80
 Gln Arg Leu Glu Ser Met Val Lys Asn Ala Phe Tyr Lys Ser Pro Leu
                  85                  90                  95    
 Arg Glu Glu Phe Val Lys Ser Gln Val Ile Lys Phe Ser Gln Gln Lys
             100                 105                 110        
 His Gly Val Leu Ala His Met Leu Leu Ile Cys Arg Phe His Ser Thr
         115                 120                 125            
 Glu Asp Pro Glu Thr Val Asp Lys Ile Val Gln Leu Val Leu His Glu
     130                 135                 140                
 Lys Leu Gln Asp Ala Val Gly Pro Pro Lys Val Asp Pro His Ser Val
 145                 150                 155                 160
 Lys Ile Lys Lys Ile Asn Lys Thr Glu Thr Asp Ser Tyr Leu Asn His
                 165                 170                 175    
 Cys Cys Gly Thr Arg Arg Ser Lys Thr Leu Gly Gln Ser Leu Arg Ile
             180                 185                 190        
 Val Gly Gly Thr Glu Val Glu Glu Gly Glu Trp Pro Trp Gln Ala Ser
         195                 200                 205            
 Leu Gln Trp Asp Gly Ser His Arg Cys Gly Ala Thr Leu Ile Asn Ala
     210                 215                 220                
 Thr Trp Leu Val Ser Ala Ala His Cys Phe Thr Thr Tyr Lys Asn Pro
 225                 230                 235                 240
 Ala Arg Trp Thr Ala Ser Phe Gly Val Thr Ile Lys Pro Ser Lys Met
                 245                 250                 255    
 Lys Arg Gly Leu Arg Arg Ile Ile Val His Glu Lys Tyr Lys His Pro
             260                 265                 270        
 Ser His Asp Tyr Asp Ile Ser Leu Ala Glu Leu Ser Ser Pro Val Pro
         275                 280                 285            
 Tyr Thr Asn Ala Val His Arg Val Cys Leu Pro Asp Ala Ser Tyr Glu
     290                 295                 300                
 Phe Gln Pro Gly Asp Val Met Phe Val Thr Gly Phe Gly Ala Leu Lys
 305                 310                 315                 320
 Asn Asp Gly Tyr Ser Gln Asn His Leu Arg Gln Ala Gln Val Thr Leu
                 325                 330                 335    
 Ile Asp Ala Thr Thr Cys Asn Glu Pro Gln Ala Tyr Asn Asp Ala Ile
             340                 345                 350        
 Thr Pro Arg Met Leu Cys Ala Gly Ser Leu Glu Gly Lys Thr Asp Ala
         355                 360                 365            
 Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Ser Ser Asp Ala Arg Asp
     370                 375                 380                
 Ile Trp Tyr Leu Ala Gly Ile Val Ser Trp Gly Asp Glu Cys Ala Lys
 385                 390                 395                 400
 Pro Asn Lys Pro Gly Val Tyr Thr Arg Val Thr Ala Leu Arg Asp Trp
                 405                 410                 415    
 Ile Thr Ser Lys Thr Gly Ile
             420            



      <210> 787
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 787
 Met Arg Pro Glu Ala His Arg Arg Pro Gln Ala Gln Thr Pro Leu Pro
   1               5                  10                  15    
 Ser Cys Glu Arg Thr Ala Gly Gln Thr Pro Lys Leu Ala Arg Gln Ala
              20                  25                  30        
 Ser Ile Glu Leu Pro Ser Met Ala Ala Ser Ser Thr Lys Ser Trp Trp
          35                  40                  45            
 Glu Thr Gly Glu Val Gln Ala Gln Ser Ala Ala Lys Thr Pro Ser Cys
      50                  55                  60                
 Lys Asp Ile Val Ala Gly Asp Met Ser Lys Lys Ser Leu Trp Glu Gln
  65                  70                  75                  80
 Lys Gly Gly Ser Lys Thr Ser Ser Thr Ile Lys Met Asp Ser Val Thr
                  85                  90                  95    
 Thr
    



      <210> 788
      <211> 431
      <212> PRT
      <213> Homo sapiens


      <400> 788
 Met Ala Ala Pro Cys Glu Gly Gln Ala Phe Ala Val Gly Val Glu Lys
   1               5                  10                  15    
 Asn Trp Gly Ala Val Val Arg Ser Pro Glu Gly Thr Pro Gln Lys Ile
              20                  25                  30        
 Arg Gln Leu Ile Asp Glu Gly Ile Ala Pro Glu Glu Gly Gly Val Asp
          35                  40                  45            
 Ala Lys Asp Thr Ser Ala Thr Ser Gln Ser Val Asn Gly Ser Pro Gln
      50                  55                  60                
 Ala Glu Gln Pro Ser Leu Glu Ser Thr Ser Lys Glu Ala Phe Phe Ser
  65                  70                  75                  80
 Arg Val Glu Thr Phe Ser Ser Leu Lys Trp Ala Gly Lys Pro Phe Glu
                  85                  90                  95    
 Leu Ser Pro Leu Val Cys Ala Lys Tyr Gly Trp Val Thr Val Glu Cys
             100                 105                 110        
 Asp Met Leu Lys Cys Ser Ser Cys Gln Ala Phe Leu Cys Ala Ser Leu
         115                 120                 125            
 Gln Pro Ala Phe Asp Phe Asp Arg Tyr Lys Gln Arg Cys Ala Glu Leu
     130                 135                 140                
 Lys Lys Ala Leu Cys Thr Ala His Glu Lys Phe Cys Phe Trp Pro Asp
 145                 150                 155                 160
 Ser Pro Ser Pro Asp Arg Phe Gly Met Leu Pro Leu Asp Glu Pro Ala
                 165                 170                 175    
 Ile Leu Val Ser Glu Phe Leu Asp Arg Phe Ser Lys Pro Leu Ser Leu
             180                 185                 190        
 Gly Pro Pro Ala Ser Phe Pro Lys Ala Gly Gly Leu Glu Asn Tyr Val
         195                 200                 205            
 Leu Asp Arg Arg Gln Asp Gln Ser Ser Pro Thr Leu Leu Glu Asp Glu
     210                 215                 220                
 Leu Asp His Arg Thr Asp Glu Arg Lys Thr Thr Ile Lys Leu Gly Ser
 225                 230                 235                 240
 Asp Ile Gln Val His Val Thr Ala Cys Ile Leu Ser Val Cys Gly Trp
                 245                 250                 255    
 Ala Cys Ser Ser Ser Leu Glu Ser Met Gln Leu Ser Leu Ile Ala Cys
             260                 265                 270        
 Ser Gln Cys Met Arg Arg Val Gly Leu Trp Gly Phe Gln Gln Ile Glu
         275                 280                 285            
 Ser Ser Met Thr Asp Leu Asp Ala Ser Phe Gly Leu Thr Ser Ser Pro
     290                 295                 300                
 Ile Pro Gly Leu Glu Gly Arg Pro Glu Arg Leu Pro Leu Val Pro Glu
 305                 310                 315                 320
 Ser Pro Arg Arg Met Met Thr Arg Ser Gln Asp Ala Thr Phe Ser Pro
                 325                 330                 335    
 Gly Ser Glu Gln Asp Thr Ser Ser Arg Ser Phe Phe Asp Pro Thr Ser
             340                 345                 350        
 Gln His Arg Asp Trp Cys Pro Trp Val Asn Ile Thr Leu Gly Lys Glu
         355                 360                 365            
 Ser Arg Glu Asn Gly Gly Thr Glu Pro Asp Ala Ser Ala Pro Ala Glu
     370                 375                 380                
 Pro Gly Trp Lys Ala Val Leu Thr Ile Leu Leu Ala His Lys Gln Ser
 385                 390                 395                 400
 Ser Gln Pro Ala Glu Thr Asp Ser Met Ser Leu Ser Glu Lys Ser Arg
                 405                 410                 415    
 Lys Val Phe Arg Ile Phe Arg Gln Trp Glu Ser Leu Cys Ser Cys
             420                 425                 430    



      <210> 789
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 789
 Met Met Asn Gly Lys Val Pro Phe Phe Phe Ser Ser Glu Ser Leu Gly
   1               5                  10                  15    
 Tyr Phe Ala Thr Gly Arg Pro Ala Asp Asn Val Met Thr Thr Gln Glu
              20                  25                  30        
 Asp Thr Thr Gly Leu His Gln Lys Thr Ser Leu Trp Thr Met Ser Arg
          35                  40                  45            
 Pro Gly Ala Lys Lys Val Met Asn Ser Tyr Phe Ile Ala Gly Cys Gly
      50                  55                  60                
 Pro Ala Val Cys Tyr Tyr Ala Val Ser Trp Leu Arg Gln Gly Phe Ser
  65                  70                  75                  80
 Ile Asn Leu Thr Ser Phe Gly Arg Ile Pro Trp Pro His Ala Gly Val
                  85                  90                  95    
 Gly Thr Cys Pro Ser Pro Gln Ser Trp Ile Ser Pro Phe Leu Gln Ser
             100                 105                 110        
 His Arg Glu His His Tyr Ala Lys Thr Ser Ser His Ser Gln Pro Ser
         115                 120                 125            
 Pro Gln Ser Leu Ala Leu Cys Leu Ala Tyr Ser Arg Cys Ser Ile Asn
     130                 135                 140                
 Ile Cys Gln Met Thr Glu Cys Ile Ser Leu Ala Ser Gly Cys His Gln
 145                 150                 155                 160
 Ala Leu Arg Glu Pro Gly Arg Ser Glu Glu Ser Phe Trp Ile Pro Ala
                 165                 170                 175    
 Thr Pro Tyr Ile Ser Asn Ile Phe Ser Glu Ser
             180                 185        



      <210> 790
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 790
 Met Ser Ala Thr Gly Pro Ile Ser Asn Tyr Tyr Val Asp Ser Leu Ile
   1               5                  10                  15    
 Ser His Asp Asn Glu Asp Leu Leu Ala Ser Arg Phe Pro Ala Thr Gly
              20                  25                  30        
 Ala His Pro Ala Ala Ala Arg Pro Ser Gly Leu Val Pro Asp Cys Ser
          35                  40                  45            
 Asp Phe Pro Ser Cys Ser Phe Ala Pro Lys Pro Ala Val Phe Ser Thr
      50                  55                  60                
 Ser Trp Ala Pro Val Pro Ser Gln Ser Ser Val Val Tyr His Pro Tyr
  65                  70                  75                  80
 Gly Pro Gln Pro His Leu Gly Ala Asp Thr Arg Tyr Met Arg Thr Trp
                  85                  90                  95    
 Leu Glu Pro Leu Ser Gly Ala Val Ser Phe Pro Ser Phe Pro Ala Gly
             100                 105                 110        
 Gly Arg His Tyr Ala Leu Lys Pro Asp Ala Tyr Pro Gly Arg Arg Ala
         115                 120                 125            
 Asp Cys Gly Pro Gly Glu Gly Arg Ser Tyr Pro Asp Tyr Met Tyr Gly
     130                 135                 140                
 Ser Pro Gly Glu Leu Arg Asp Arg Ala Pro Gln Thr Leu Pro Ser Pro
 145                 150                 155                 160
 Glu Ala Asp Ala Leu Ala Gly Ser Lys His Lys Glu Glu Lys Ala Asp
                 165                 170                 175    
 Leu Asp Pro Ser Asn Pro Val Ala Asn Trp Ile His Ala Arg Ser Thr
             180                 185                 190        
 Arg Lys Lys Arg Cys Pro Tyr Thr Lys Tyr Gln Thr Leu Glu Leu Glu
         195                 200                 205            
 Lys Glu Phe Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg Arg Tyr Glu
     210                 215                 220                
 Val Ala Arg Val Leu Asn Leu Thr Glu Arg Gln Val Lys Ile Trp Phe
 225                 230                 235                 240
 Gln Asn Arg Arg Met Lys Met Lys Lys Met Asn Lys Glu Lys Thr Asp
                 245                 250                 255    
 Lys Glu Gln Ser
             260



      <210> 791
      <211> 1067
      <212> PRT
      <213> Homo sapiens


      <400> 791
 Met Glu Lys His Ile Lys Arg Ser Lys His Leu Glu Asn Ala Lys Lys
   1               5                  10                  15    
 Asn Asn Ile Gly Leu Ser Phe Glu Glu Cys Ile Glu Arg Val Cys Ile
              20                  25                  30        
 Gly Ala Asn Asp Lys Lys Glu Glu Phe Asp Val Ser Gly Asn Gly Arg
          35                  40                  45            
 Ile Glu Gly His Ile Gly Val Gln Leu Gln Glu His Ser Tyr Leu Glu
      50                  55                  60                
 Lys Gly Met Leu Ala Ser Glu Glu Leu Ser Gln Ser Gly Gly Ser Thr
  65                  70                  75                  80
 Lys Asp Asp Glu Leu Ala Ser Thr Thr Thr Pro Lys Arg Gly Arg Pro
                  85                  90                  95    
 Lys Gly Asn Ile Ser Arg Thr Cys Ser His Cys Gly Leu Leu Ala Ser
             100                 105                 110        
 Ser Ile Thr Asn Leu Thr Val His Ile Arg Arg Lys His Ser His Gln
         115                 120                 125            
 Tyr Ser Tyr Leu Cys Lys Val Cys Lys Tyr Tyr Thr Val Thr Lys Gly
     130                 135                 140                
 Asp Met Glu Arg His Cys Ala Thr Lys Lys His Lys Gly Arg Val Glu
 145                 150                 155                 160
 Ile Glu Ala Ser Gly Lys His Ser Ser Asp Ile Ile Val Gly Pro Glu
                 165                 170                 175    
 Gly Gly Ser Leu Glu Ala Gly Lys Lys Asn Ala Gly Ser Ala Val Thr
             180                 185                 190        
 Met Ser Asp Glu His Ala Asn Lys Pro Ala Glu Ser Pro Thr Ser Val
         195                 200                 205            
 Leu Glu Lys Pro Asp Arg Gly Asn Ser Ile Glu Ala Glu Val Glu Asn
     210                 215                 220                
 Val Phe His Ser Leu Asp Gly Glu Val Asn Ser His Leu Leu Asp Glu
 225                 230                 235                 240
 Lys Glu Gln Ile Ser Ser Glu Pro Glu Asp Phe Ala Gln Pro Gly Asp
                 245                 250                 255    
 Val Tyr Ser Gln Arg Asp Val Thr Gly Thr Gly Glu Asn Lys Cys Leu
             260                 265                 270        
 His Cys Glu Phe Ser Ala His Ser Ser Ala Ser Leu Glu Leu His Val
         275                 280                 285            
 Lys Arg Lys His Thr Lys Glu Phe Glu Phe Tyr Cys Met Ala Cys Asp
     290                 295                 300                
 Tyr Tyr Ala Val Thr Arg Arg Glu Met Thr Arg His Ala Ala Thr Glu
 305                 310                 315                 320
 Lys His Lys Met Lys Arg Gln Ser Tyr Leu Asn Ser Ala Asn Val Glu
                 325                 330                 335    
 Ala Gly Ser Ala Asp Met Ser Lys Asn Ile Ile Met Pro Glu Glu Glu
             340                 345                 350        
 His Gln Gln Asn Ser Glu Glu Phe Gln Ile Ile Ser Gly Gln Pro Ser
         355                 360                 365            
 Asp Thr Leu Lys Ser Arg Asn Ala Ala Asp Cys Ser Ile Leu Asn Glu
     370                 375                 380                
 Asn Thr Asn Leu Asp Met Ser Lys Val Leu Cys Ala Ala Asp Ser Val
 385                 390                 395                 400
 Glu Val Glu Thr Glu Glu Glu Ser Asn Phe Asn Glu Asp His Ser Phe
                 405                 410                 415    
 Cys Glu Thr Phe Gln Gln Ala Pro Val Lys Asp Lys Val Arg Lys Pro
             420                 425                 430        
 Glu Glu Met Met Ser Leu Thr Met Ser Ser Asn Tyr Gly Ser Pro Ser
         435                 440                 445            
 Arg Phe Gln Asn Glu Asn Ser Gly Ser Ser Ala Leu Asn Cys Glu Thr
     450                 455                 460                
 Ala Lys Lys Asn His Glu Ile Ser Asn Asp Ala Gly Glu Leu Arg Val
 465                 470                 475                 480
 His Cys Glu Gly Glu Gly Gly Asn Ala Gly Asp Gly Gly Gly Val Val
                 485                 490                 495    
 Pro His Arg His Leu Cys Pro Val Thr Leu Asp Gly Glu Arg Ser Ala
             500                 505                 510        
 Glu Ser Pro Val Leu Val Val Thr Arg Ile Thr Arg Glu Gln Gly Asn
         515                 520                 525            
 Leu Glu Ser Gly Gly Gln Asn Arg Val Ala Arg Gly His Gly Leu Glu
     530                 535                 540                
 Asp Leu Lys Gly Asp Gln Glu Asp Pro Val Leu Gly Asn Lys Glu Ile
 545                 550                 555                 560
 Leu Met Asn Ser Gln His Glu Thr Glu Phe Ile Leu Glu Glu Asp Gly
                 565                 570                 575    
 Pro Ala Ser Asp Ser Thr Val Glu Ser Ser Asp Val Tyr Glu Thr Ile
             580                 585                 590        
 Ile Ser Ile Asp Asp Lys Gly Gln Ala Met Tyr Ser Ser Gly Arg Phe
         595                 600                 605            
 Asp Ser Ser Ile Ile Arg Ile Lys Asn Pro Glu Asp Gly Glu Leu Ile
     610                 615                 620                
 Asp Gln Ser Glu Glu Gly Leu Ile Ala Thr Gly Val Arg Ile Ser Glu
 625                 630                 635                 640
 Leu Pro Leu Lys Asp Cys Ala Gln Gly Val Lys Lys Lys Lys Ser Glu
                 645                 650                 655    
 Gly Ser Ser Ile Gly Glu Ser Thr Arg Ile Arg Cys Asp Asp Cys Gly
             660                 665                 670        
 Phe Leu Ala Asp Gly Leu Ser Gly Leu Asn Val His Ile Ala Met Lys
         675                 680                 685            
 His Pro Thr Lys Glu Lys His Phe His Cys Leu Leu Cys Gly Lys Ser
     690                 695                 700                
 Phe Tyr Thr Glu Ser Asn Leu His Gln His Leu Ala Ser Ala Gly His
 705                 710                 715                 720
 Met Arg Asn Glu Gln Ala Ser Val Glu Glu Leu Pro Glu Gly Gly Ala
                 725                 730                 735    
 Thr Phe Lys Cys Val Lys Cys Thr Glu Pro Phe Asp Ser Glu Gln Asn
             740                 745                 750        
 Leu Phe Leu His Ile Lys Gly Gln His Glu Glu Leu Leu Arg Glu Val
         755                 760                 765            
 Asn Lys Tyr Ile Val Glu Asp Thr Glu Gln Ile Asn Arg Glu Arg Glu
     770                 775                 780                
 Glu Asn Gln Gly Asn Val Cys Lys Tyr Cys Gly Lys Met Cys Arg Ser
 785                 790                 795                 800
 Ser Asn Ser Met Ala Phe Leu Ala His Ile Arg Thr His Thr Gly Ser
                 805                 810                 815    
 Lys Pro Phe Lys Cys Lys Ile Cys His Phe Ala Thr Ala Gln Leu Gly
             820                 825                 830        
 Asp Ala Arg Asp His Val Lys Arg His Leu Gly Met Arg Glu Tyr Lys
         835                 840                 845            
 Cys His Val Cys Gly Val Ala Phe Val Met Lys Lys His Leu Asn Thr
     850                 855                 860                
 His Leu Leu Gly Lys His Gly Val Gly Thr Pro Lys Glu Arg Lys Phe
 865                 870                 875                 880
 Thr Cys His Leu Cys Asp Arg Ser Phe Thr Glu Lys Trp Ala Leu Asn
                 885                 890                 895    
 Asn His Met Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys Thr Trp
             900                 905                 910        
 Pro Thr Cys His Tyr Ser Phe Leu Thr Ala Ser Ala Met Lys Asp His
         915                 920                 925            
 Tyr Arg Thr His Thr Gly Glu Lys Ser Phe Leu Cys Asp Leu Cys Gly
     930                 935                 940                
 Phe Ala Gly Gly Thr Arg His Ala Leu Thr Lys His Arg Arg Gln His
 945                 950                 955                 960
 Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Asn Phe Ala Ser Thr
                 965                 970                 975    
 Thr Gln Ser His Leu Thr Arg His Lys Arg Val His Thr Gly Glu Lys
             980                 985                 990        
 Pro Tyr Arg Cys Pro Trp Cys Asp Tyr Arg Ser Asn Cys Ala Glu Asn
         995                1000                1005            
 Ile Arg Lys His Ile Leu His Thr Gly Lys His Glu Gly Val Lys Met
    1010                1015                1020                
 Tyr Asn Cys Pro Lys Cys Asp Tyr Gly Thr Asn Val Pro Val Glu Phe
1025                1030                1035                1040
 Arg Asn His Leu Lys Glu Gln His Pro Asp Ile Glu Asn Pro Asp Leu
                1045                1050                1055    
 Ala Tyr Leu His Ala Gly Lys Gly Gln Lys Leu
            1060                1065        



      <210> 792
      <211> 264
      <212> PRT
      <213> Homo sapiens


      <400> 792
 Met Arg Ala Thr Gln Glu Asp Phe Asp Lys Val Met Gln Val Val Arg
   1               5                  10                  15    
 Glu Gln Leu Ala Arg Thr Leu Ala Leu Lys Pro Thr Ser Leu Glu Leu
              20                  25                  30        
 Phe Arg Thr Lys Val Asn Ala Leu Thr Tyr Gly Glu Val Leu Arg Leu
          35                  40                  45            
 Arg Gln Thr Glu Arg Leu His Gln Glu Gly Thr Leu Ala Pro Pro Ile
      50                  55                  60                
 Leu Glu Leu Arg Glu Lys Leu Lys Pro Glu Leu Met Gly Leu Ile Arg
  65                  70                  75                  80
 Gln Gln Arg Leu Leu Arg Leu Cys Glu Gly Thr Leu Phe Arg Lys Ile
                  85                  90                  95    
 Ser Ser Arg Arg Arg Gln Asp Lys Leu Trp Phe Cys Cys Leu Ser Pro
             100                 105                 110        
 Asn His Lys Leu Leu Gln Tyr Gly Asp Met Glu Glu Gly Ala Ser Pro
         115                 120                 125            
 Pro Thr Leu Glu Ser Leu Pro Glu Gln Leu Pro Val Ala Asp Met Arg
     130                 135                 140                
 Ala Leu Leu Thr Gly Lys Asp Cys Pro His Val Arg Glu Lys Gly Ser
 145                 150                 155                 160
 Gly Lys Gln Asn Lys Asp Leu Tyr Glu Leu Ala Phe Ser Ile Ser Tyr
                 165                 170                 175    
 Asp Arg Gly Glu Glu Glu Ala Tyr Leu Asn Phe Ile Ala Pro Ser Lys
             180                 185                 190        
 Arg Glu Phe Tyr Leu Trp Thr Asp Gly Leu Ser Ala Leu Leu Gly Ser
         195                 200                 205            
 Pro Met Gly Ser Glu Gln Thr Arg Leu Asp Leu Glu Gln Leu Leu Thr
     210                 215                 220                
 Met Glu Thr Lys Leu Arg Leu Leu Glu Leu Glu Asn Val Pro Ile Pro
 225                 230                 235                 240
 Glu Arg Pro Pro Pro Val Pro Pro Pro Pro Thr Asn Phe Asn Phe Cys
                 245                 250                 255    
 Tyr Asp Cys Ser Ile Ala Glu Pro
             260                



      <210> 793
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 793
 Met Val Ser Phe Leu Leu Asp Leu Gly Ala His Pro Asp Val Gln Asp
   1               5                  10                  15    
 Arg Met Gly Cys Thr Pro Thr Met Arg Ala Ala Glu Leu Gly His Glu
              20                  25                  30        
 Leu Ser Met Glu Ile Leu Ala Lys Ala Lys Ala Asp Met Thr Ile Val
          35                  40                  45            
 Asp Asn Glu Gly Lys Gly Lys Asn Pro Asp Ile Leu Ser Ser Arg Leu
      50                  55                  60                
 Gln Phe Ile Leu
  65            



      <210> 794
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 794
 Met Ala Glu Val Glu Glu Thr Leu Lys Arg Ile Gln Ser His Lys Gly
   1               5                  10                  15    
 Val Ile Gly Thr Met Val Val Asn Ala Glu Gly Ile Pro Ile Arg Thr
              20                  25                  30        
 Thr Leu Asp Asn Ser Thr Thr Val Gln Tyr Ala Gly Leu Leu His His
          35                  40                  45            
 Leu Thr Met Lys Ala Lys Ser Thr Val Arg Asp Ile Asp Pro Gln Asn
      50                  55                  60                
 Asp Leu Thr Phe Leu Arg Ile Arg Ser Lys Lys His Glu Ile Met Val
  65                  70                  75                  80
 Ala Pro Asp Lys Glu Tyr Leu Leu Ile Val Ile Gln Asn Pro Cys Glu
                  85                  90                  95    





      <210> 795
      <211> 243
      <212> PRT
      <213> Homo sapiens


      <400> 795
 Met Glu Lys Val Ile Lys Asp Glu Asn Val Thr Leu Tyr Val Trp Ala
   1               5                  10                  15    
 Asn Leu Lys Lys Asn Pro Arg His Arg Ser Val Arg Phe Ser Glu Thr
              20                  25                  30        
 Gln Ile Gly Phe Glu Ile Pro Arg Ile Leu Ala Thr Ser Asp Ile Ala
          35                  40                  45            
 Val Arg Leu Leu His Thr His Tyr Asp His Val Ser Ala Leu His Pro
      50                  55                  60                
 Val Ser Thr Pro Ser Lys Glu Tyr Thr Ser Ala Val Thr Glu Leu Val
  65                  70                  75                  80
 Lys Asp Asp Val Lys Asn Val Glu Lys Ala Ile Ser Lys Glu Val Glu
                  85                  90                  95    
 Glu Glu Ser Lys Gln Gln Glu Arg Gly Ser His Leu Ile Gln Glu Glu
             100                 105                 110        
 Glu Ile Lys Val Glu Glu Glu Gln Gly Asp Ile Glu Val Lys Met Ser
         115                 120                 125            
 Ser Ala Glu Glu Glu Ser Glu Ala Ile Lys Cys Glu Arg Glu Met Lys
     130                 135                 140                
 Val Leu Ser Glu Thr Val Ser Ala Ala Gln Leu Leu Leu Val Glu Asn
 145                 150                 155                 160
 Ser Ser Glu Lys Pro Asp Phe Phe Glu Asp Asn Val Val Asp Leu Cys
                 165                 170                 175    
 Gln Phe Thr Thr Leu Gly Gly Val Tyr His Leu Asp Ile Leu Glu Leu
             180                 185                 190        
 Pro Pro Gln Cys Lys Pro Val Lys Gly Trp Met Ile Val Glu Ile Leu
         195                 200                 205            
 Lys Glu Gly Leu Gln Lys Tyr Thr Tyr Pro Pro Glu Thr Thr Glu Glu
     210                 215                 220                
 Phe Glu Thr Glu Asn Ala Phe Pro Pro Ile Glu Val His Leu Arg Phe
 225                 230                 235                 240
 Met Arg Met
            



      <210> 796
      <211> 606
      <212> PRT
      <213> Homo sapiens


      <400> 796
 Met Ile Val Arg Glu Lys Thr Gln Lys His Leu Asp Asp Tyr Ala Lys
   1               5                  10                  15    
 Gln Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val Met Ser Asp Thr
              20                  25                  30        
 Glu Tyr Ala Glu Trp Leu Arg Asn His Phe Leu Ala Glu Thr Ser Ile
          35                  40                  45            
 Asp Asn Arg Glu Glu Leu Leu Leu Glu Ser Ala Met Arg Leu Glu Asn
      50                  55                  60                
 Lys Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp Arg Leu Gln Glu
  65                  70                  75                  80
 Gly Val Pro Glu Ser Ile Glu Ala Leu His Lys Ala Gly Ile Lys Ile
                  85                  90                  95    
 Trp Met Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile Ala Tyr
             100                 105                 110        
 Ala Cys Lys Leu Leu Glu Pro Asp Asp Lys Leu Phe Ile Leu Asn Thr
         115                 120                 125            
 Gln Ser Lys Asp Ala Cys Gly Met Leu Met Ser Thr Ile Leu Lys Glu
     130                 135                 140                
 Leu Gln Lys Lys Thr Gln Ala Leu Pro Glu Gln Val Ser Leu Ser Glu
 145                 150                 155                 160
 Asp Leu Leu Gln Pro Pro Val Pro Arg Asp Ser Gly Leu Arg Ala Gly
                 165                 170                 175    
 Leu Ile Ile Thr Gly Lys Thr Leu Glu Phe Ala Leu Gln Glu Ser Leu
             180                 185                 190        
 Gln Lys Gln Phe Leu Glu Leu Thr Ser Trp Cys Gln Ala Val Val Cys
         195                 200                 205            
 Cys Arg Ala Thr Pro Leu Gln Lys Ser Glu Val Val Lys Leu Val Arg
     210                 215                 220                
 Ser His Leu Gln Val Met Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp
 225                 230                 235                 240
 Val Ser Met Ile Gln Val Ala Asp Ile Gly Ile Gly Val Ser Gly Gln
                 245                 250                 255    
 Glu Gly Met Gln Ala Val Met Ala Ser Asp Phe Ala Val Ser Gln Phe
             260                 265                 270        
 Lys His Leu Ser Lys Leu Leu Leu Val His Gly His Trp Cys Tyr Thr
         275                 280                 285            
 Arg Leu Ser Asn Met Ile Leu Tyr Phe Phe Tyr Lys Asn Val Ala Tyr
     290                 295                 300                
 Val Asn Leu Leu Phe Trp Tyr Gln Phe Phe Cys Gly Phe Ser Gly Thr
 305                 310                 315                 320
 Ser Met Thr Asp Tyr Trp Val Leu Ile Phe Phe Asn Leu Leu Phe Thr
                 325                 330                 335    
 Ser Ala Pro Pro Val Ile Tyr Gly Val Leu Glu Lys Asp Val Ser Ala
             340                 345                 350        
 Glu Thr Leu Met Gln Leu Pro Glu Leu Tyr Lys Ser Gly Gln Lys Ser
         355                 360                 365            
 Glu Ala Tyr Leu Pro His Thr Phe Trp Ile Thr Leu Leu Asp Ala Phe
     370                 375                 380                
 Tyr Gln Ser Leu Val Cys Phe Phe Val Pro Tyr Phe Thr Tyr Gln Gly
 385                 390                 395                 400
 Ser Asp Thr Asp Ile Phe Ala Phe Gly Asn Pro Leu Asn Thr Ala Ala
                 405                 410                 415    
 Leu Phe Ile Val Leu Leu His Leu Val Ile Glu Ser Lys Ser Leu Thr
             420                 425                 430        
 Trp Ile His Leu Leu Val Ile Ile Gly Ser Ile Leu Ser Tyr Phe Leu
         435                 440                 445            
 Phe Ala Ile Val Phe Gly Ala Met Cys Val Thr Cys Asn Pro Pro Ser
     450                 455                 460                
 Asn Pro Tyr Trp Ile Met Gln Glu His Met Leu Asp Pro Val Phe Tyr
 465                 470                 475                 480
 Leu Val Cys Ile Leu Thr Thr Ser Ile Ala Leu Leu Pro Arg Phe Val
                 485                 490                 495    
 Tyr Arg Val Leu Gln Gly Ser Leu Phe Pro Ser Pro Ile Leu Arg Ala
             500                 505                 510        
 Lys His Phe Asp Arg Leu Thr Pro Glu Glu Arg Thr Lys Ala Leu Lys
         515                 520                 525            
 Lys Trp Arg Gly Ala Gly Lys Met Asn Gln Val Thr Ser Lys Tyr Ala
     530                 535                 540                
 Asn Gln Ser Ala Gly Lys Ser Gly Arg Arg Pro Met Pro Gly Pro Ser
 545                 550                 555                 560
 Ala Val Phe Ala Met Lys Ser Ala Thr Ser Cys Ala Ile Glu Gln Gly
                 565                 570                 575    
 Asn Leu Ser Leu Cys Glu Thr Ala Leu Asp Gln Gly Tyr Ser Glu Thr
             580                 585                 590        
 Lys Ala Phe Glu Met Ala Gly Pro Ser Lys Gly Lys Glu Ser
         595                 600                 605    



      <210> 797
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 797
 Met Leu Phe Cys Leu Cys Leu Leu Phe Ile Val Cys Lys Ile Gly Trp
   1               5                  10                  15    
 Thr Ala Asn Arg Arg Met Arg Ala Ala Gln Pro Gly Leu Thr Phe Phe
              20                  25                  30        
 Gln Leu Ile His Lys Gln Gly Asp Met Gln Gly Ala Glu Gly Pro Trp
          35                  40                  45            
 Asp Val Thr Asn Ser Ala Phe His Trp Arg Leu Tyr Asp Gln Thr Ala
      50                  55                  60                
 Asn Cys Leu Ser
  65            



      <210> 798
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 798
 Met Glu Gly His Val Tyr Trp Thr Asp Asp Glu Val Trp Ala Ile Arg
   1               5                  10                  15    
 Arg Ala Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Ile Asn Thr Lys
              20                  25                  30        
 Ile Asn Asp Pro Asp Asp Ile Ala Val Asn Trp Val Ala Arg Ser Leu
          35                  40                  45            
 Tyr Trp Thr His Thr Gly Thr Glu His Ile Glu Val Thr Cys Leu Asn
      50                  55                  60                
 Ser Thr Ser His Lys Ile Leu Val Ser Glu Asp Met Asp Glu Pro Arg
  65                  70                  75                  80
 Ala Ile Ala Leu His Pro Glu Met Gly Leu Thr Tyr Trp Ile Asp Trp
                  85                  90                  95    
 Gly Glu Asn Pro Glu Ile Lys Arg Ala Asn Leu Asp Arg Gln Glu Leu
             100                 105                 110        
 Arg Val Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu Ala Leu
         115                 120                 125            
 Asp Leu Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr Asp Lys
     130                 135                 140                
 Ile Glu Ala Ile Ser Val Asp Glu Thr Lys Arg Gln Thr Leu Leu Lys
 145                 150                 155                 160
 Asp Lys Leu Pro His Ile Phe Arg Phe Thr Leu Leu Gly Asp Phe Ile
                 165                 170                 175    
 Tyr Trp Thr Ala Trp Gln His His Ser Ile Lys Arg Val His Lys Val
             180                 185                 190        
 Lys Ala Asn Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu Met Gly
         195                 200                 205            
 Leu Lys Ala Val Asn Val Asp Lys Val Val Gly Thr Asn Pro His Ala
     210                 215                 220                
 Asp Arg Asn Gly Gly Ala Ala Thr Cys Ala Ser Ser Arg Pro Thr Gln
 225                 230                 235                 240
 Pro Gly Leu Ala Ala Pro Ser Arg Ala Trp Asn Cys
                 245                 250        



      <210> 799
      <211> 408
      <212> PRT
      <213> Homo sapiens


      <400> 799
 Met Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln
   1               5                  10                  15    
 Phe Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser
              20                  25                  30        
 Asp Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Asn
          35                  40                  45            
 Pro Arg Ser Tyr Gln Gln Trp Val His Thr Val Lys Lys Gly Gly Ala
      50                  55                  60                
 Leu Phe Asn Thr Ala Met Thr Lys Ala Thr Pro Ala Val Arg Thr Ala
  65                  70                  75                  80
 Tyr Lys Phe Ala Lys Asn His Ala Lys Leu Gly Leu Lys Glu Val Lys
                  85                  90                  95    
 Ser Lys Leu Lys His Lys Glu Asn Glu Glu Asp Tyr Gly Thr Cys Ser
             100                 105                 110        
 Ser Ser Val Gln Tyr Thr Pro Val Tyr Lys Leu His Asn Glu Lys Gly
         115                 120                 125            
 Gly Asn Ser Glu Lys Arg Lys Leu Ala Gln Ala Arg Leu Lys Arg Pro
     130                 135                 140                
 Leu Lys Ser Leu Asp Gly Ala Leu Tyr Asp Asp Glu Asp Asp Asp Asp
 145                 150                 155                 160
 Ile Glu Arg Ala Ser Lys Leu Ser Ser Glu Asp Gly Glu Glu Ala Ser
                 165                 170                 175    
 Ala Tyr Leu Tyr Glu Ser Asp Asp Ser Val Glu Thr Arg Val Lys Thr
             180                 185                 190        
 Pro Tyr Ser Gly Glu Met Asp Leu Leu Gly Glu Ile Leu Asp Thr Leu
         195                 200                 205            
 Ser Thr His Ser Ser Asp Gln Gly Lys Leu Ala Ala Ala Lys Ser Leu
     210                 215                 220                
 Asp Phe Phe Arg Ser Met Asp Asp Ile Asp Tyr Lys Pro Thr Asn Lys
 225                 230                 235                 240
 Ser Asn Ala Pro Ser Glu Asn Asn Leu Ala Phe Leu Cys Gly Gly Ser
                 245                 250                 255    
 Gly Asp Gln Ala Glu Trp Asn Leu Gly Gln Asp Asp Ser Ala Leu His
             260                 265                 270        
 Gly Lys His Leu Pro Pro Ser Pro Arg Lys Arg Val Ser Ser Ser Gly
         275                 280                 285            
 Leu Thr Asp Ser Leu Phe Ile Leu Lys Glu Glu Asn Ser Asn Lys His
     290                 295                 300                
 Leu Gly Ala Asp Asn Val Ser Asp Pro Thr Ser Gly Leu Asp Phe Gln
 305                 310                 315                 320
 Leu Thr Ser Pro Glu Val Ser Gln Thr Asp Lys Gly Lys Thr Glu Lys
                 325                 330                 335    
 Arg Glu Thr Leu Ser Gln Ile Ser Asp Asp Leu Leu Ile Pro Gly Leu
             340                 345                 350        
 Gly Arg His Ser Ser Thr Phe Val Pro Trp Glu Lys Glu Gly Lys Glu
         355                 360                 365            
 Ala Lys Glu Thr Ser Glu Asp Ile Gly Leu Leu His Glu Val Val Ser
     370                 375                 380                
 Leu Cys His Met Thr Ser Asp Phe Gln Gln Ser Leu Asn Ile Ser Asp
 385                 390                 395                 400
 Lys Asn Thr Asn Gly Asn Gln Thr
                 405            



      <210> 800
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 800
 Met Ser Ser Val Phe Gly Lys Pro Arg Ala Gly Ser Gly Pro Gln Ser
   1               5                  10                  15    
 Ala Pro Leu Glu Val Asn Leu Ala Ile Leu Gly Arg Arg Gly Ala Gly
              20                  25                  30        
 Lys Ser Ala Leu Thr Val Lys Phe Leu Thr Lys Arg Phe Ile Ser Glu
          35                  40                  45            
 Tyr Asp Pro Asn Leu Glu Asp Thr Tyr Ser Ser Glu Glu Thr Val Asp
      50                  55                  60                
 His Gln Pro Val His Leu Arg Val Met Asp Thr Ala Asp Leu Asp Thr
  65                  70                  75                  80
 Pro Arg Asn Cys Glu Arg Tyr Leu Asn Trp Ala His Ala Phe Leu Val
                  85                  90                  95    
 Val Tyr Ser Val Asp Ser Arg Gln Ser Phe Asp Ser Ser Ser Ser Tyr
             100                 105                 110        
 Leu Glu Leu Leu Ala Leu His Ala Lys Glu Thr Gln Arg Ser Ile Pro
         115                 120                 125            
 Ala Leu Leu Leu Gly Asn Lys Leu Asp Met Ala Gln Tyr Arg Gln Val
     130                 135                 140                
 Thr Lys Ala Glu Gly Val Ala Leu Ala Gly Arg Phe Gly Cys Leu Phe
 145                 150                 155                 160
 Phe Glu Val Ser Ala Cys Leu Asp Phe Glu His Val Gln His Val Phe
                 165                 170                 175    
 His Glu Ala Val Arg Glu Ala Arg Arg Glu Leu Glu Lys Ser Pro Leu
             180                 185                 190        
 Thr Arg Pro Leu Phe Ile Ser Glu Glu Arg Ala Leu Pro His Gln Ala
         195                 200                 205            
 Pro Leu Thr Ala Arg His Gly Leu Ala Ser Cys Thr Phe Asn Thr Leu
     210                 215                 220                
 Ser Thr Ile Asn Leu Lys Glu Met Pro Thr Val Ala Gln Ala Lys Leu
 225                 230                 235                 240
 Val Thr Val Lys Ser Ser Arg Ala Gln Ser Lys Arg Lys Ala Pro Thr
                 245                 250                 255    
 Leu Thr Leu Leu Lys Gly Phe Lys Ile Phe
             260                 265    



      <210> 801
      <211> 1021
      <212> PRT
      <213> Homo sapiens


      <400> 801
 Met Leu Ser Cys Leu Lys Glu Glu Met Pro Pro Gln Glu Leu Thr Arg
   1               5                  10                  15    
 Arg Leu Ala Thr Val Ile Thr His Val Asp Glu Ile Met Gln Gln Glu
              20                  25                  30        
 Val Arg Pro Leu Met Ala Val Glu Ile Ile Glu Gln Leu His Arg Gln
          35                  40                  45            
 Phe Ala Ile Leu Ser Gly Gly Arg Gly Glu Asp Gly Ala Pro Ile Ile
      50                  55                  60                
 Thr Phe Pro Glu Phe Ser Gly Phe Lys His Ile Pro Asp Glu Asp Phe
  65                  70                  75                  80
 Leu Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Val Glu Ala Ala
                  85                  90                  95    
 Ser Ile Gly Leu Ile Val Val Ile Asp Arg Arg Arg Asp Lys Trp Ser
             100                 105                 110        
 Ser Val Lys Ala Ser Leu Thr Arg Ile Ala Val Ala Phe Pro Gly Asn
         115                 120                 125            
 Leu Gln Leu Ile Phe Ile Leu Arg Pro Ser Arg Phe Ile Gln Arg Thr
     130                 135                 140                
 Phe Thr Asp Ile Gly Ile Lys Tyr Tyr Arg Asn Glu Phe Lys Thr Lys
 145                 150                 155                 160
 Val Pro Ile Ile Met Val Asn Ser Val Ser Asp Leu His Gly Tyr Ile
                 165                 170                 175    
 Asp Lys Ser Gln Leu Thr Arg Glu Leu Gly Gly Thr Leu Glu Tyr Arg
             180                 185                 190        
 His Gly Gln Trp Val Asn His Arg Thr Ala Ile Glu Asn Phe Ala Leu
         195                 200                 205            
 Thr Leu Lys Thr Thr Ala Gln Met Leu Gln Thr Phe Gly Ser Cys Leu
     210                 215                 220                
 Ala Thr Ala Glu Leu Pro Arg Ser Met Leu Ser Thr Glu Asp Leu Leu
 225                 230                 235                 240
 Met Ser His Thr Arg Gln Arg Asp Lys Leu Gln Asp Glu Leu Lys Leu
                 245                 250                 255    
 Leu Gly Lys Gln Gly Thr Thr Leu Leu Ser Cys Ile Gln Glu Pro Ala
             260                 265                 270        
 Thr Lys Cys Pro Asn Ser Lys Leu Asn Leu Asn Gln Leu Glu Asn Val
         275                 280                 285            
 Thr Thr Met Glu Arg Leu Leu Val Gln Leu Asp Glu Thr Glu Lys Ala
     290                 295                 300                
 Phe Ser His Phe Trp Ser Glu His His Leu Lys Leu Asn Gln Cys Leu
 305                 310                 315                 320
 Gln Leu Gln His Phe Glu His Asp Phe Cys Lys Ala Lys Leu Ala Leu
                 325                 330                 335    
 Asp Asn Leu Leu Glu Glu Gln Ala Glu Phe Thr Gly Ile Gly Asp Ser
             340                 345                 350        
 Val Met His Val Glu Gln Ile Leu Lys Glu His Lys Lys Leu Glu Glu
         355                 360                 365            
 Lys Ser Gln Glu Pro Leu Glu Lys Ala Gln Leu Leu Ala Leu Val Gly
     370                 375                 380                
 Asp Gln Leu Ile Gln Ser His His Tyr Ala Ala Asp Ala Ile Arg Pro
 385                 390                 395                 400
 Arg Cys Val Glu Leu Arg His Leu Cys Asp Asp Phe Ile Asn Gly Asn
                 405                 410                 415    
 Lys Lys Lys Trp Asp Ile Leu Gly Lys Ser Leu Glu Phe His Arg Gln
             420                 425                 430        
 Leu Asp Lys Val Ser Gln Trp Cys Glu Ala Gly Ile Tyr Leu Leu Ala
         435                 440                 445            
 Ser Gln Ala Val Asp Lys Cys Gln Ser Arg Glu Gly Val Asp Ile Ala
     450                 455                 460                
 Leu Asn Asp Ile Ala Thr Phe Leu Gly Thr Val Lys Glu Tyr Pro Leu
 465                 470                 475                 480
 Leu Ser Pro Lys Glu Phe Tyr Asn Glu Phe Glu Leu Leu Leu Thr Leu
                 485                 490                 495    
 Asp Ala Lys Ala Lys Ala Gln Lys Val Leu Gln Arg Leu Asp Asp Val
             500                 505                 510        
 Gln Glu Ile Phe His Lys Arg Gln Val Ser Leu Met Lys Leu Ala Ala
         515                 520                 525            
 Lys Gln Thr Arg Pro Val Gln Pro Val Ala Pro His Pro Glu Ser Ser
     530                 535                 540                
 Pro Lys Trp Val Ser Ser Lys Thr Ser Gln Pro Ser Thr Ser Val Pro
 545                 550                 555                 560
 Leu Ala Arg Pro Leu Arg Thr Ser Glu Glu Pro Tyr Thr Glu Thr Glu
                 565                 570                 575    
 Leu Asn Ser Arg Gly Lys Glu Asp Asp Glu Thr Lys Phe Glu Val Lys
             580                 585                 590        
 Ser Glu Glu Ile Phe Glu Ser His His Glu Arg Gly Asn Pro Glu Leu
         595                 600                 605            
 Glu Gln Gln Ala Arg Leu Gly Asp Leu Ser Pro Arg Arg Arg Ile Ile
     610                 615                 620                
 Arg Asp Leu Leu Glu Thr Glu Glu Ile Tyr Ile Lys Glu Ile Lys Ser
 625                 630                 635                 640
 Ile Ile Asp Gly Tyr Ile Thr Pro Met Asp Phe Ile Trp Leu Lys His
                 645                 650                 655    
 Leu Ile Pro Asp Val Leu Gln Asn Asn Lys Asp Phe Leu Phe Gly Asn
             660                 665                 670        
 Ile Arg Glu Leu Tyr Glu Phe His Asn Arg Thr Phe Leu Lys Glu Leu
         675                 680                 685            
 Glu Lys Cys Ala Glu Asn Pro Glu Leu Leu Ala His Cys Phe Leu Lys
     690                 695                 700                
 Arg Lys Glu Asp Leu Gln Ile Tyr Phe Lys Tyr His Lys Asn Leu Pro
 705                 710                 715                 720
 Arg Ala Arg Ala Ile Trp Gln Glu Cys Gln Asp Cys Ala Tyr Phe Gly
                 725                 730                 735    
 Val Cys Gln Arg Gln Leu Asp His Asn Leu Pro Leu Phe Lys Tyr Leu
             740                 745                 750        
 Lys Gly Pro Ser Gln Arg Leu Ile Lys Tyr Gln Met Leu Leu Lys Gly
         755                 760                 765            
 Leu Leu Asp Phe Glu Ser Pro Glu Asp Met Glu Ile Asp Pro Gly Glu
     770                 775                 780                
 Leu Gly Gly Ser Ala Lys Asp Gly Pro Lys Arg Thr Lys Asp Ser Ala
 785                 790                 795                 800
 Phe Ser Thr Glu Leu Gln Gln Ala Leu Ala Val Ile Glu Asp Leu Ile
                 805                 810                 815    
 Lys Ser Cys Glu Leu Ala Val Asp Leu Ala Ala Val Thr Glu Cys Pro
             820                 825                 830        
 Asp Asp Ile Gly Lys Leu Gly Lys Leu Leu Leu His Gly Pro Phe Ser
         835                 840                 845            
 Val Trp Thr Ile His Lys Asp Arg Tyr Lys Met Lys Asp Leu Ile Arg
     850                 855                 860                
 Phe Lys Pro Ser Gln Arg Gln Ile Tyr Leu Phe Glu Arg Gly Ile Val
 865                 870                 875                 880
 Phe Cys Lys Ile Arg Met Glu Pro Gly Asp Gln Gly Leu Ser Pro His
                 885                 890                 895    
 Tyr Ser Phe Lys Lys Ala Met Lys Leu Met Thr Leu Ser Ile Arg Gln
             900                 905                 910        
 Leu Gly Arg Gly Ser His Arg Lys Phe Glu Ile Ala Ser Arg Asn Gly
         915                 920                 925            
 Leu Glu Lys Tyr Ile Leu Gln Ala Ala Ser Lys Glu Ile Arg Asp Cys
     930                 935                 940                
 Trp Phe Ser Glu Ile Ser Lys Leu Leu Met Glu Gln Gln Asn Asn Ile
 945                 950                 955                 960
 Lys Asp Gln Gly Asn Pro Gln Phe Glu Met Ser Thr Ser Lys Gly Ser
                 965                 970                 975    
 Gly Ala Gly Ser Gly Gly Pro Trp Ile Lys Asn Met Glu Arg Ala Thr
             980                 985                 990        
 Thr Ser Lys Glu Asp Pro Ala Ser Ser Thr Gly Gly Ile Lys Gly Arg
         995                1000                1005            
 Glu Gly Pro Met Gly Glu Trp Ser Thr Glu Ala Val Gly
    1010                1015                1020    



      <210> 802
      <211> 1822
      <212> PRT
      <213> Homo sapiens


      <400> 802
 Met Tyr Pro Asn Trp Gly Arg Tyr Gly Gly Ser Ser His Tyr Pro Pro
   1               5                  10                  15    
 Pro Pro Val Pro Pro Pro Pro Pro Val Ala Leu Pro Glu Ala Ser Pro
              20                  25                  30        
 Gly Pro Gly Tyr Ser Ser Ser Thr Thr Pro Ala Ala Pro Ser Ser Ser
          35                  40                  45            
 Gly Phe Met Ser Phe Arg Glu Gln His Leu Ala Gln Leu Gln Gln Leu
      50                  55                  60                
 Gln Gln Met His Gln Lys Gln Met Gln Cys Val Leu Gln Pro His His
  65                  70                  75                  80
 Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Val Met Pro Gly Gly Gly
                  85                  90                  95    
 Tyr Gly Asp Trp Gln Pro Pro Pro Pro Pro Met Pro Pro Pro Pro Gly
             100                 105                 110        
 Pro Ala Leu Ser Tyr Gln Lys Gln Gln Gln Tyr Lys His Gln Met Leu
         115                 120                 125            
 His His Gln Arg Asp Gly Pro Pro Gly Leu Val Pro Met Glu Leu Glu
     130                 135                 140                
 Ser Pro Pro Glu Ser Pro Pro Val Pro Pro Gly Ser Tyr Met Pro Pro
 145                 150                 155                 160
 Ser Gln Ser Tyr Met Pro Pro Pro Gln Pro Pro Pro Ser Tyr Tyr Pro
                 165                 170                 175    
 Pro Thr Ser Ser Gln Pro Tyr Leu Pro Pro Ala Gln Pro Ser Pro Ser
             180                 185                 190        
 Gln Ser Pro Pro Ser Gln Ser Tyr Leu Ala Pro Thr Pro Ser Tyr Ser
         195                 200                 205            
 Ser Ser Ser Ser Ser Ser Gln Ser Tyr Leu Ser His Ser Gln Ser Tyr
     210                 215                 220                
 Leu Pro Ser Ser Gln Ala Ser Pro Ser Arg Pro Ser Gln Gly His Ser
 225                 230                 235                 240
 Lys Ser Gln Leu Leu Ala Pro Pro Pro Pro Ser Ala Pro Pro Gly Asn
                 245                 250                 255    
 Lys Thr Thr Val Gln Gln Glu Pro Leu Glu Ser Gly Ala Lys Asn Lys
             260                 265                 270        
 Ser Thr Glu Gln Gln Gln Ala Ala Pro Glu Pro Asp Pro Ser Thr Met
         275                 280                 285            
 Thr Pro Gln Glu Gln Gln Gln Tyr Trp Tyr Arg Gln His Leu Leu Ser
     290                 295                 300                
 Leu Gln Gln Arg Thr Lys Val His Leu Pro Gly His Lys Lys Gly Pro
 305                 310                 315                 320
 Val Val Ala Lys Asp Thr Pro Glu Pro Val Lys Glu Glu Val Thr Val
                 325                 330                 335    
 Pro Ala Thr Ser Gln Val Pro Glu Ser Pro Ser Ser Glu Glu Pro Pro
             340                 345                 350        
 Leu Pro Pro Pro Asn Glu Glu Val Pro Pro Pro Leu Pro Pro Glu Glu
         355                 360                 365            
 Pro Gln Ser Glu Asp Pro Glu Glu Asp Ala Arg Leu Lys Gln Leu Gln
     370                 375                 380                
 Ala Ala Ala Ala His Trp Gln Gln His Gln Gln His Arg Val Gly Phe
 385                 390                 395                 400
 Gln Tyr Gln Gly Ile Met Gln Lys His Thr Gln Leu Gln Gln Ile Leu
                 405                 410                 415    
 Gln Gln Tyr Gln Gln Ile Ile Gln Pro Pro Pro His Ile Gln Ala Thr
             420                 425                 430        
 Thr Pro Pro Pro Gly Ile Pro Pro Pro Gly Val Pro Gln Gly Ile Pro
         435                 440                 445            
 Pro Gln Leu Thr Ala Ala Pro Val Pro Pro Ala Ser Ser Ser Gln Ser
     450                 455                 460                
 Ser Gln Val Pro Glu Lys Pro Arg Pro Ala Leu Leu Pro Thr Pro Val
 465                 470                 475                 480
 Ser Phe Gly Ser Ala Pro Pro Thr Thr Tyr His Pro Pro Leu Gln Ser
                 485                 490                 495    
 Ala Gly Pro Ser Glu Gln Val Asn Ser Lys Ala Pro Leu Ser Lys Ser
             500                 505                 510        
 Ala Leu Pro Tyr Ser Ser Phe Ser Ser Asp Gln Gly Leu Gly Glu Ser
         515                 520                 525            
 Ser Ala Ala Pro Ser Gln Pro Ile Thr Ala Val Lys Asp Met Pro Val
     530                 535                 540                
 Arg Ser Gly Gly Leu Leu Pro Asp Pro Pro Arg Ser Ser Tyr Leu Glu
 545                 550                 555                 560
 Ser Pro Arg Gly Pro Arg Phe Asp Gly Pro Arg Arg Phe Glu Asp Leu
                 565                 570                 575    
 Gly Ser Arg Cys Glu Gly Pro Arg Pro Lys Gly Pro Arg Phe Glu Gly
             580                 585                 590        
 Asn Arg Pro Asp Gly Pro Arg Pro Arg Tyr Glu Gly His Pro Ala Glu
         595                 600                 605            
 Gly Thr Lys Ser Lys Trp Gly Met Ile Pro Arg Gly Pro Ala Ser Gln
     610                 615                 620                
 Phe Tyr Ile Thr Pro Ser Thr Ser Leu Ser Pro Arg Gln Ser Gly Pro
 625                 630                 635                 640
 Gln Trp Lys Gly Pro Lys Pro Ala Phe Gly Gln Gln His Gln Gln Gln
                 645                 650                 655    
 Pro Lys Ser Gln Ala Glu Pro Leu Ser Gly Asn Lys Glu Pro Leu Ala
             660                 665                 670        
 Asp Thr Ser Ser Asn Gln Gln Lys Asn Phe Lys Met Gln Ser Ala Ala
         675                 680                 685            
 Phe Ser Ile Ala Ala Asp Val Lys Asp Val Lys Ala Ala Gln Ser Asn
     690                 695                 700                
 Glu Asn Leu Ser Asp Ser Gln Gln Glu Pro Pro Lys Ser Glu Val Ser
 705                 710                 715                 720
 Glu Gly Pro Val Glu Pro Ser Asn Trp Asp Gln Asn Val Gln Ser Met
                 725                 730                 735    
 Glu Thr Gln Ile Asp Lys Ala Gln Ala Val Thr Gln Pro Val Pro Leu
             740                 745                 750        
 Ala Asn Lys Pro Val Pro Ala Gln Ser Thr Phe Pro Ser Lys Thr Gly
         755                 760                 765            
 Gly Met Glu Gly Gly Thr Ala Val Ala Thr Ser Ser Leu Thr Ala Asp
     770                 775                 780                
 Asn Asp Phe Lys Pro Val Gly Ile Gly Leu Pro His Ser Glu Asn Asn
 785                 790                 795                 800
 Gln Asp Lys Gly Leu Pro Arg Pro Asp Asn Arg Asp Asn Arg Leu Glu
                 805                 810                 815    
 Gly Asn Arg Gly Asn Ser Ser Ser Tyr Arg Gly Pro Gly Gln Ser Arg
             820                 825                 830        
 Met Glu Asp Thr Arg Asp Lys Gly Leu Val Asn Arg Gly Arg Gly Gln
         835                 840                 845            
 Ala Ile Ser Arg Gly Pro Gly Leu Val Lys Gln Glu Asp Phe Arg Asp
     850                 855                 860                
 Lys Met Met Gly Arg Arg Glu Asp Ser Arg Glu Lys Met Asn Arg Gly
 865                 870                 875                 880
 Glu Gly Ser Arg Asp Arg Gly Leu Val Arg Pro Gly Ser Ser Arg Glu
                 885                 890                 895    
 Lys Val Pro Gly Gly Leu Gln Gly Ser Gln Asp Arg Gly Ala Ala Gly
             900                 905                 910        
 Ser Arg Glu Arg Gly Pro Pro Arg Arg Ala Gly Ser Gln Glu Arg Gly
         915                 920                 925            
 Pro Leu Arg Arg Ala Gly Ser Arg Glu Arg Ile Pro Pro Arg Arg Ala
     930                 935                 940                
 Gly Ser Arg Glu Arg Gly Pro Pro Arg Gly Pro Gly Ser Arg Glu Arg
 945                 950                 955                 960
 Gly Leu Gly Arg Ser Asp Phe Gly Arg Asp Arg Gly Pro Phe Arg Pro
                 965                 970                 975    
 Glu Pro Gly Asp Gly Gly Glu Lys Met Tyr Pro Tyr His Arg Asp Glu
             980                 985                 990        
 Pro Pro Arg Ala Pro Trp Asn His Gly Glu Glu Arg Gly His Glu Glu
         995                1000                1005            
 Phe Pro Leu Asp Gly Arg Asn Ala Pro Met Glu Arg Glu Arg Leu Asp
    1010                1015                1020                
 Asp Trp Asp Arg Glu Arg Tyr Trp Arg Glu Cys Glu Arg Asp Tyr Gln
1025                1030                1035                1040
 Asp Asp Thr Leu Glu Leu Tyr Asn Arg Glu Asp Arg Phe Ser Ala Pro
                1045                1050                1055    
 Pro Ser Arg Ser His Asp Gly Asp Arg Arg Gly Pro Trp Trp Asp Asp
            1060                1065                1070        
 Trp Glu Arg Asp Gln Asp Met Asp Glu Asp Tyr Asn Arg Glu Met Glu
        1075                1080                1085            
 Arg Asp Met Asp Arg Asp Val Asp Arg Ile Ser Arg Pro Met Asp Met
    1090                1095                1100                
 Tyr Asp Arg Ser Leu Asp Asn Glu Trp Asp Arg Asp Tyr Gly Arg Pro
1105                1110                1115                1120
 Leu Asp Glu Gln Glu Ser Gln Phe Arg Glu Arg Asp Ile Pro Ser Leu
                1125                1130                1135    
 Pro Pro Leu Pro Pro Leu Pro Pro Leu Pro Pro Leu Asp Arg Tyr Arg
            1140                1145                1150        
 Asp Asp Arg Trp Arg Glu Glu Arg Asn Arg Glu His Gly Tyr Asp Arg
        1155                1160                1165            
 Asp Phe Arg Asp Arg Gly Glu Leu Arg Ile Arg Glu Tyr Pro Glu Arg
    1170                1175                1180                
 Gly Asp Thr Trp Arg Glu Lys Arg Asp Tyr Val Pro Asp Arg Met Asp
1185                1190                1195                1200
 Trp Glu Arg Glu Arg Leu Ser Asp Arg Trp Tyr Pro Ser Asp Val Asp
                1205                1210                1215    
 Arg His Ser Pro Met Ala Glu His Met Pro Ser Ser His His Ser Ser
            1220                1225                1230        
 Glu Met Met Gly Ser Asp Ala Ser Leu Asp Ser Asp Gln Gly Leu Gly
        1235                1240                1245            
 Gly Val Met Val Leu Ser Gln Arg Gln His Glu Ile Ile Leu Lys Ala
    1250                1255                1260                
 Ala Gln Glu Leu Lys Met Leu Arg Glu Gln Lys Glu Gln Leu Gln Lys
1265                1270                1275                1280
 Met Lys Asp Phe Gly Ser Glu Pro Gln Met Ala Asp His Leu Pro Pro
                1285                1290                1295    
 Gln Glu Ser Arg Leu Gln Asn Thr Ser Ser Arg Pro Gly Met Tyr Pro
            1300                1305                1310        
 Pro Pro Gly Ser Tyr Arg Pro Pro Pro Pro Met Gly Lys Pro Pro Gly
        1315                1320                1325            
 Ser Ile Val Arg Pro Ser Ala Pro Pro Ala Arg Ser Ser Val Pro Val
    1330                1335                1340                
 Thr Arg Pro Pro Val Pro Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu
1345                1350                1355                1360
 Pro Pro Pro Pro Pro Val Ile Lys Pro Gln Thr Ser Ala Val Glu Gln
                1365                1370                1375    
 Glu Arg Trp Asp Glu Asp Ser Phe Tyr Gly Leu Trp Asp Thr Asn Asp
            1380                1385                1390        
 Glu Gln Gly Leu Asn Ser Glu Phe Lys Ser Glu Thr Ala Ala Ile Pro
        1395                1400                1405            
 Ser Ala Pro Val Leu Pro Pro Pro Pro Val His Ser Ser Ile Pro Pro
    1410                1415                1420                
 Pro Gly Pro Val Pro Met Gly Met Pro Pro Met Ser Lys Pro Pro Pro
1425                1430                1435                1440
 Val Gln Gln Thr Val Asp Tyr Gly His Gly Arg Asp Ile Ser Thr Asn
                1445                1450                1455    
 Lys Val Glu Gln Ile Pro Tyr Gly Glu Arg Ile Thr Leu Arg Pro Asp
            1460                1465                1470        
 Pro Leu Pro Glu Arg Ser Thr Phe Glu Thr Glu His Ala Gly Gln Arg
        1475                1480                1485            
 Asp Arg Tyr Asp Arg Glu Arg Asp Arg Glu Pro Tyr Phe Asp Arg Gln
    1490                1495                1500                
 Ser Asn Val Ile Ala Asp His Arg Asp Phe Lys Arg Asp Arg Glu Thr
1505                1510                1515                1520
 His Arg Asp Arg Asp Arg Asp Arg Gly Val Ile Asp Tyr Asp Arg Asp
                1525                1530                1535    
 Arg Phe Asp Arg Glu Arg Arg Pro Arg Asp Asp Arg Ala Gln Ser Tyr
            1540                1545                1550        
 Arg Asp Lys Lys Asp His Ser Ser Ser Arg Arg Gly Gly Phe Asp Arg
        1555                1560                1565            
 Pro Ser Tyr Asp Arg Lys Ser Asp Arg Pro Val Tyr Glu Gly Pro Ser
    1570                1575                1580                
 Met Phe Gly Gly Glu Arg Arg Thr Tyr Pro Glu Glu Arg Met Pro Leu
1585                1590                1595                1600
 Pro Ala Pro Ser Leu Ser His Gln Pro Pro Pro Ala Pro Arg Val Glu
                1605                1610                1615    
 Lys Lys Pro Glu Ser Lys Asn Val Asp Asp Ile Leu Lys Pro Pro Gly
            1620                1625                1630        
 Arg Glu Ser Arg Pro Glu Arg Ile Val Val Ile Met Arg Gly Leu Pro
        1635                1640                1645            
 Gly Ser Gly Lys Thr His Val Ala Lys Leu Ile Arg Val Met Glu Tyr
    1650                1655                1660                
 Glu Tyr Glu Ala Glu Met Glu Glu Thr Tyr Arg Thr Ser Met Phe Lys
1665                1670                1675                1680
 Thr Phe Lys Lys Thr Leu Asp Asp Gly Phe Phe Pro Phe Ile Ile Leu
                1685                1690                1695    
 Asp Ala Ile Asn Asp Arg Val Arg His Phe Asp Gln Phe Trp Ser Ala
            1700                1705                1710        
 Ala Lys Thr Lys Gly Phe Glu Val Tyr Leu Ala Glu Met Ser Ala Asp
        1715                1720                1725            
 Asn Gln Thr Cys Gly Lys Arg Asn Ile His Gly Arg Lys Leu Lys Glu
    1730                1735                1740                
 Ile Asn Lys Met Ala Asp His Trp Glu Thr Ala Pro Arg His Met Met
1745                1750                1755                1760
 Arg Leu Asp Ile Arg Ser Leu Leu Gln Asp Ala Ala Ile Glu Glu Val
                1765                1770                1775    
 Glu Met Glu Asp Phe Asp Ala Asn Ile Glu Glu Gln Lys Glu Glu Lys
            1780                1785                1790        
 Lys Asp Ala Glu Glu Glu Glu Ser Glu Leu Val Gly Asp Arg Pro Thr
        1795                1800                1805            
 Thr Leu Asn Ser Val Ser Leu Leu Lys Phe Leu Lys Lys Val
    1810                1815                1820        



      <210> 803
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 803
 Met Ser Tyr Pro Val Thr Ser Gln Pro Gln Cys Ala Thr Thr Ser Cys
   1               5                  10                  15    
 Tyr Gln Thr Gln Leu Ser Asp Trp His Thr Gly Leu Thr Asp Cys Cys
              20                  25                  30        
 Asn Asp Met Pro Val Cys Leu Cys Gly Thr Phe Ala Pro Leu Cys Leu
          35                  40                  45            
 Ala Cys Arg Ile Ser Asp Asp Phe Gly Glu Cys Cys Cys Ala Pro Tyr
      50                  55                  60                
 Leu Pro Gly Gly Leu His Ser Ile Arg Thr Gly Met Arg Glu Arg Tyr
  65                  70                  75                  80
 His Ile Gln Gly Ser Val Gly His Asp Trp Ala Ala Leu Thr Phe Cys
                  85                  90                  95    
 Leu Pro Cys Ala Leu Cys Gln Met Ala Arg Glu Leu Lys Ile Arg Glu
             100                 105                 110        





      <210> 804
      <211> 189
      <212> PRT
      <213> Homo sapiens


      <400> 804
 Met Ala Leu Val Arg Gly Gly Trp Leu Trp Arg Gln Ser Ser Ile Leu
   1               5                  10                  15    
 Arg Arg Trp Lys Arg Asn Trp Phe Ala Leu Trp Leu Asp Gly Thr Leu
              20                  25                  30        
 Gly Tyr Tyr His Asp Glu Thr Ala Gln Asp Glu Glu Asp Arg Val Leu
          35                  40                  45            
 Ile His Phe Asn Val Arg Asp Ile Lys Ile Gly Pro Glu Cys His Asp
      50                  55                  60                
 Val Gln Pro Pro Glu Gly Arg Ser Arg Asp Gly Leu Leu Thr Val Asn
  65                  70                  75                  80
 Leu Arg Glu Gly Gly Arg Leu His Leu Cys Ala Glu Thr Lys Asp Asp
                  85                  90                  95    
 Ala Leu Ala Trp Lys Thr Ala Leu Leu Glu Ala Asn Ser Thr Pro Val
             100                 105                 110        
 Arg Val Tyr Ser Pro Tyr Gln Asp Tyr Tyr Glu Val Val Pro Pro Asn
         115                 120                 125            
 Ala His Glu Ala Thr Tyr Val Arg Ser Tyr Tyr Gly Pro Pro Tyr Ala
     130                 135                 140                
 Gly Pro Gly Val Thr His Val Ile Val Arg Glu Asp Pro Cys Tyr Ser
 145                 150                 155                 160
 Ala Gly Ala Pro Leu Ala Met Gly Met Leu Ala Gly Ala Ala Thr Gly
                 165                 170                 175    
 Ala Ala Leu Gly Ser Leu Met Trp Ser Pro Cys Trp Phe
             180                 185                



      <210> 805
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 805
 Met Asp Glu Lys Ser Asn Lys Leu Leu Leu Ala Leu Val Met Leu Phe
   1               5                  10                  15    
 Leu Phe Ala Val Ile Val Leu Gln Tyr Val Cys Pro Gly Thr Glu Cys
              20                  25                  30        
 Gln Leu Leu Arg Leu Gln Ala Phe Ser Ser Pro Val Pro Asp Pro Tyr
          35                  40                  45            
 Arg Ser Glu Asp Glu Ser Ser Ala Arg Phe Val Pro Arg Tyr Asn Phe
      50                  55                  60                
 Thr Arg Gly Asp Leu Leu Arg Lys Val Asp Phe Asp Ile Lys Gly Asp
  65                  70                  75                  80
 Asp Leu Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr Phe
                  85                  90                  95    
 Gly Arg His Leu Val Arg Asn Ile Gln Leu Glu Gln Pro Cys Glu Cys
             100                 105                 110        
 Arg Val Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys Arg Glu
         115                 120                 125            
 Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu His
     130                 135                 140                
 Ala Asp Trp Thr Glu Leu Thr Ser Cys Val Pro Ser Val Val Asp Gly
 145                 150                 155                 160
 Lys Arg Asp Ala Arg Leu Arg Pro Ser Arg Trp Arg Ile Phe Gln Ile
                 165                 170                 175    
 Leu Asp Ala Ala Ser Lys Asp Lys Arg Gly Ser Pro Asn Thr Asn Ala
             180                 185                 190        
 Gly Ala Asn Ser Pro Ser Ser Thr Lys Thr Arg Asn Thr Ser Lys Ser
         195                 200                 205            
 Gly Lys Asn Phe His Tyr Ile Thr Ile Leu Arg Asp Pro Val Ser Arg
     210                 215                 220                
 Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp Lys Ala
 225                 230                 235                 240
 Ser Leu His Val Cys Asp Gly Arg Pro Pro Thr Ser Glu Glu Leu Pro
                 245                 250                 255    
 Ser Cys Tyr Thr Gly Asp Asp Trp Ser Gly Cys Pro Leu Lys Glu Phe
             260                 265                 270        
 Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Cys Ala Cys Ser
         275                 280                 285            
 Pro Thr
     290



      <210> 806
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 806
 Met Lys Ala Asp Arg Lys Arg Leu Lys Gly Glu Lys Thr Asp Leu Val
   1               5                  10                  15    
 Ser Gln Met Gln Gln Leu Tyr Ala Thr Leu Glu Ser Arg Glu Glu Gln
              20                  25                  30        
 Leu Arg Asp Phe Ile Arg Asn Tyr Glu Gln His Arg Lys Glu Ser Glu
          35                  40                  45            
 Asp Ala Val Lys Ala Leu Ala Lys Glu Lys Asp Leu Leu Glu Arg Glu
      50                  55                  60                
 Lys Trp Glu Leu Arg Arg Gln Ala Lys Glu Ala Thr Asp His Ala Thr
  65                  70                  75                  80
 Ala Leu Arg Ser Gln Leu Asp Leu Lys Asp Asn Arg Met Lys Glu Leu
                  85                  90                  95    
 Glu Ala Glu Leu Ala Met Ala Lys Gln Ser Leu Ala Thr Leu Thr Lys
             100                 105                 110        
 Asp Val Pro Lys Arg His Ser Leu Ala Met Pro Gly Glu Thr Val Leu
         115                 120                 125            
 Asn Gly Asn Gln Glu Trp Val Val Gln Ala Asp Leu Pro Leu Thr Ala
     130                 135                 140                
 Ala Ile Arg Gln Ser Gln Gln Thr Leu Tyr His Ser His Pro Pro His
 145                 150                 155                 160
 Pro Ala Asp Arg Gln Ala Val Arg Val Ser Pro Cys His Ser Arg Gln
                 165                 170                 175    
 Pro Ser Val Ile Ser Asp Ala Ser Ala Ala Glu Gly Asp Arg Ser Ser
             180                 185                 190        
 Thr Pro Ser Asp Ile Asn Ser Pro Arg His Arg Thr His Ser Leu Cys
         195                 200                 205            
 Asn Gly Asp Ser Pro Gly Pro Val Gln Lys Asn Leu His Asn Pro Ile
     210                 215                 220                
 Val Gln Ser Leu Glu Asp Leu Glu Asp Gln Lys Arg Lys Lys Lys Lys
 225                 230                 235                 240
 Glu Lys Met Gly Phe Gly Ser Ile Ser Arg Val Phe Ala Arg Gly Lys
                 245                 250                 255    
 Gln Arg Lys Ser Leu Asp Pro Gly Leu Phe Asp Gly Thr Ala Pro Asp
             260                 265                 270        
 Tyr Tyr Ile Glu Glu Asp Ala Asp Trp
         275                 280    



      <210> 807
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 807
 Met Ser Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln
   1               5                  10                  15    
 Gly Ser Lys Leu Ile Arg Lys Thr Lys Glu Ala Pro Phe Val Pro Val
              20                  25                  30        
 Gly Glu Arg Asn Gly His Leu Cys Ala Glu Arg Leu Val His Lys Thr
          35                  40                  45            
 Phe Leu Lys Ile Tyr Ser Arg Arg Phe Lys Ile Ser Ser Ala Leu Glu
      50                  55                  60                
 Ile Val Leu Ala Trp Ile Gln Pro Ser Ala Pro Ser Ala Pro Leu Ser
  65                  70                  75                  80
 Leu Ser Glu Leu Leu Ala Pro Pro Arg Pro Pro
                  85                  90    



      <210> 808
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 808
 Met Glu Phe Arg Thr Lys Arg Cys Gly Gln Ala Thr Gly Pro Ala Gly
   1               5                  10                  15    
 Asn Ile Met Ala Glu Lys Val Asn Asn Phe Pro Pro Leu Pro Lys Phe
              20                  25                  30        
 Ile Pro Leu Lys Pro Cys Phe Tyr Gln Asp Phe Glu Ala Asp Ile Pro
          35                  40                  45            
 Pro Gln His Val Ser Met Thr Lys Arg Leu Tyr Tyr Leu Trp Met Leu
      50                  55                  60                
 Asn Ser Val Thr Leu Ala Val Asn Leu Val Gly Cys Leu Ala Trp Leu
  65                  70                  75                  80
 Ile Gly Gly Gly Gly Ala Thr Asn Phe Gly Leu Ala Phe Leu Trp Leu
                  85                  90                  95    
 Ile Leu Phe Thr Pro Cys Ser Tyr Val Cys Trp Phe Arg Pro Ile Tyr
             100                 105                 110        
 Lys Ala Phe Lys Thr Asp Ser Ser Phe Ser Phe Met Ala Phe Phe Phe
         115                 120                 125            
 Thr Phe Met Ala Gln Leu Val Ile Ser Ile Ile Gln Ala Val Gly Ile
     130                 135                 140                
 Pro Gly Trp Gly Val Cys Gly Trp Ile Ala Thr Ile Ser Phe Phe Gly
 145                 150                 155                 160
 Thr Asn Ile Gly Ser Ala Val Val Met Leu Ile Pro Thr Val Met Phe
                 165                 170                 175    
 Thr Val Met Ala Val Phe Ser Phe Ile Ala Leu Ser Met Val His Lys
             180                 185                 190        
 Phe Tyr Arg Gly Ser Gly Gly Ser Phe Ser Lys Ala Gln Glu Glu Trp
         195                 200                 205            
 Thr Thr Gly Ala Trp Lys Asn Pro His Val Gln Gln Ala Ala Gln Asn
     210                 215                 220                
 Ala Ala Met Gly Ala Ala Gln Gly Ala Met Asn Gln Pro Gln Thr Gln
 225                 230                 235                 240
 Tyr Ser Ala Thr Pro Asn Tyr Thr Tyr Ser Asn Glu Met
                 245                 250            



      <210> 809
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 809
 Met Arg Leu Lys Val Gly Phe Gln Gly Gly Gly Cys Phe Arg Lys Asp
   1               5                  10                  15    
 Ala Leu Cys Leu Glu Gly Gly Val Ser Ala Arg Trp Ala Arg Ala Pro
              20                  25                  30        
 His Ser Ala Pro Leu Arg Pro Pro Arg Glu Leu His Ala Ala Pro Pro
          35                  40                  45            
 Pro Ala Thr Pro Thr Gln Thr Val Val Arg Pro Ala Gly Phe Pro Arg
      50                  55                  60                
 Arg Thr Arg Leu Met Val Arg Ser Ala Pro Pro Thr Gln Arg Pro Pro
  65                  70                  75                  80
 Thr Gly Ser Gly Cys Val Ser Gly Leu Trp Arg Lys Gly Leu Gly Leu
                  85                  90                  95    
 Arg Pro Gln Thr Leu Leu Arg Val Gly Gly Val Val Leu Ser Ser Ala
             100                 105                 110        
 Pro Ala Leu Arg Pro Arg Leu Gly Pro Cys Leu Arg Pro Pro Pro Ser
         115                 120                 125            
 Asp
    



      <210> 810
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 810
 Met Ile Leu Glu Asn Met Leu Cys Gln Asn Arg Lys Val Asn Gln Val
   1               5                  10                  15    
 Gly Gly Arg His Arg Ile Ser Leu Lys Glu Leu Gln Phe Glu Gly Asp
              20                  25                  30        
 Ala Lys Arg Ile Ser Lys Lys Met Thr Ile Ser Asp Thr Arg Gly Ile
          35                  40                  45            
 Gly Ala His Gln Val Gly Arg Ser Thr Asn Leu Asp Trp Gly Leu Ser
      50                  55                  60                
 Glu Gly Ser Arg Arg Lys Thr Leu Leu Lys Met Lys Leu Thr Tyr Tyr
  65                  70                  75                  80
 Leu Ile Leu Leu Asn Ile Leu Arg Gln Val Phe Ile Cys Glu Trp Cys
                  85                  90                  95    
 Leu His Asp His Asn Ile Asn Thr Glu Tyr Cys Ser Lys Asn Met Thr
             100                 105                 110        
 Ser Leu Tyr Val Glu Asp Glu Met Asn Arg Asn
         115                 120            



      <210> 811
      <211> 4315
      <212> PRT
      <213> Homo sapiens


      <400> 811
 Met Pro Leu Glu Glu Leu Gly Gln Gln Val Asp Cys Asp Arg Met Arg
   1               5                  10                  15    
 Gly Leu Met Cys Ala Asn Ser Gln Gln Ser Pro Pro Leu Cys His Asp
              20                  25                  30        
 Tyr Glu Leu Arg Val Leu Cys Cys Glu Tyr Val Pro Cys Gly Pro Ser
          35                  40                  45            
 Pro Ala Pro Gly Thr Ser Pro Gln Pro Ser Leu Ser Ala Ser Thr Glu
      50                  55                  60                
 Pro Ala Val Pro Thr Pro Thr Gln Thr Thr Ala Thr Glu Lys Thr Thr
  65                  70                  75                  80
 Leu Trp Val Thr Pro Ser Ile Arg Ser Thr Ala Ala Leu Thr Ser Gln
                  85                  90                  95    
 Thr Gly Ser Ser Ser Gly Pro Val Thr Val Thr Pro Ser Ala Pro Gly
             100                 105                 110        
 Thr Thr Thr Cys Gln Pro Arg Cys Gln Trp Thr Glu Trp Phe Asp Glu
         115                 120                 125            
 Asp Tyr Pro Lys Ser Glu Gln Leu Gly Gly Asp Val Glu Ser Tyr Asp
     130                 135                 140                
 Lys Ile Arg Ala Ala Gly Gly His Leu Cys Gln Gln Pro Lys Asp Ile
 145                 150                 155                 160
 Glu Cys Gln Ala Glu Ser Phe Pro Asn Trp Thr Leu Ala Gln Val Gly
                 165                 170                 175    
 Gln Lys Val His Cys Asp Val His Phe Gly Leu Val Cys Arg Asn Trp
             180                 185                 190        
 Glu Gln Glu Gly Val Phe Lys Met Cys Tyr Asn Tyr Arg Ile Arg Val
         195                 200                 205            
 Leu Cys Cys Ser Asp Asp His Cys Arg Gly Arg Ala Thr Thr Pro Pro
     210                 215                 220                
 Pro Thr Thr Glu Leu Glu Thr Ala Thr Thr Thr Thr Thr Gln Ala Leu
 225                 230                 235                 240
 Phe Ser Thr Pro Gln Pro Thr Ser Ser Pro Gly Leu Thr Arg Ala Pro
                 245                 250                 255    
 Pro Ala Ser Thr Thr Ala Val Pro Thr Leu Ser Glu Gly Leu Thr Ser
             260                 265                 270        
 Pro Arg Tyr Thr Ser Thr Leu Gly Thr Ala Thr Thr Gly Gly Pro Arg
         275                 280                 285            
 Gln Ser Ala Gly Ser Thr Glu Pro Thr Val Pro Gly Val Ala Thr Ser
     290                 295                 300                
 Thr Leu Pro Thr Arg Ser Ala Leu Pro Gly Thr Thr Gly Ser Leu Gly
 305                 310                 315                 320
 Thr Trp Arg Pro Ser Gln Pro Pro Thr Leu Ala Pro Thr Thr Met Ala
                 325                 330                 335    
 Thr Ser Arg Ala Arg Pro Thr Gly Thr Ala Ser Thr Ala Ser Lys Glu
             340                 345                 350        
 Pro Leu Thr Thr Ser Leu Ala Pro Thr Leu Thr Ser Glu Leu Ser Thr
         355                 360                 365            
 Ser Gln Ala Glu Thr Ser Thr Pro Arg Thr Glu Thr Thr Met Ser Pro
     370                 375                 380                
 Leu Thr Asn Thr Thr Thr Ser Gln Gly Thr Thr Arg Cys Gln Pro Lys
 385                 390                 395                 400
 Cys Glu Trp Thr Glu Trp Phe Asp Val Asp Phe Pro Thr Ser Gly Val
                 405                 410                 415    
 Ala Ser Gly Asp Met Glu Thr Phe Glu Asn Ile Arg Ala Ala Gly Gly
             420                 425                 430        
 Lys Met Cys Trp Ala Pro Lys Ser Ile Glu Cys Arg Ala Glu Asn Tyr
         435                 440                 445            
 Pro Glu Val Ser Ile Asp Gln Val Gly Gln Val Leu Thr Cys Ser Leu
     450                 455                 460                
 Glu Thr Gly Leu Thr Cys Lys Asn Glu Asp Gln Thr Gly Arg Phe Asn
 465                 470                 475                 480
 Met Cys Phe Asn Tyr Asn Val Arg Val Leu Cys Cys Asp Asp Tyr Ser
                 485                 490                 495    
 His Cys Pro Ser Thr Leu Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser
             500                 505                 510        
 Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Pro Thr Thr Thr Ala Thr
         515                 520                 525            
 Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala
     530                 535                 540                
 Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val
 545                 550                 555                 560
 Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala Thr Ala
                 565                 570                 575    
 Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe
             580                 585                 590        
 Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser
         595                 600                 605            
 Gln Thr Thr Thr Pro Met Ala Thr Met Ser Thr Ala Thr Pro Ser Ser
     610                 615                 620                
 Thr Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr
 625                 630                 635                 640
 Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly
                 645                 650                 655    
 Thr Ala His Thr Thr Lys Val Leu Thr Thr Thr Thr Thr Gly Phe Thr
             660                 665                 670        
 Ala Thr Pro Ser Ser Ser Pro Gly Arg Ala Arg Thr Leu Pro Val Trp
         675                 680                 685            
 Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro
     690                 695                 700                
 Ser Ser Ile Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr Thr Thr
 705                 710                 715                 720
 Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr
                 725                 730                 735    
 Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile
             740                 745                 750        
 Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr
         755                 760                 765            
 Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr
     770                 775                 780                
 Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro
 785                 790                 795                 800
 Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro
                 805                 810                 815    
 Ser Ser Pro His Thr Val Cys Thr Ala Trp Thr Ser Ala Thr Ser Gly
             820                 825                 830        
 Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His
         835                 840                 845            
 Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala Leu
     850                 855                 860                
 Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro
 865                 870                 875                 880
 Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr Ala
                 885                 890                 895    
 Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Gln
             900                 905                 910        
 Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu Pro
         915                 920                 925            
 Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly
     930                 935                 940                
 Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly
 945                 950                 955                 960
 Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala
                 965                 970                 975    
 Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser
             980                 985                 990        
 Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe
         995                1000                1005            
 Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly
    1010                1015                1020                
 His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser
1025                1030                1035                1040
 Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr
                1045                1050                1055    
 Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro Thr Ser Thr Leu Arg
            1060                1065                1070        
 Thr Ala Pro Pro Pro Lys Val Leu Thr Thr Thr Ala Thr Thr Pro Thr
        1075                1080                1085            
 Val Thr Ser Ser Lys Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr
    1090                1095                1100                
 Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser
1105                1110                1115                1120
 Val Thr Pro Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu
                1125                1130                1135    
 Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser
            1140                1145                1150        
 Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr Ala Thr Ala
        1155                1160                1165            
 Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro
    1170                1175                1180                
 Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe
1185                1190                1195                1200
 Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val
                1205                1210                1215    
 Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr
            1220                1225                1230        
 Pro Ser Ser Ile Pro Gly Thr Thr His Thr Ala Thr Val Leu Thr Thr
        1235                1240                1245            
 Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser
    1250                1255                1260                
 Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr
1265                1270                1275                1280
 Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr
                1285                1290                1295    
 Arg Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala
            1300                1305                1310        
 Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr
        1315                1320                1325            
 Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser
    1330                1335                1340                
 Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser
1345                1350                1355                1360
 Gly Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser
                1365                1370                1375    
 His Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala
            1380                1385                1390        
 Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser
        1395                1400                1405            
 Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr
    1410                1415                1420                
 Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser
1425                1430                1435                1440
 Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu
                1445                1450                1455    
 Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro
            1460                1465                1470        
 Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala
        1475                1480                1485            
 Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln
    1490                1495                1500                
 Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys
1505                1510                1515                1520
 Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys
                1525                1530                1535    
 Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr
            1540                1545                1550        
 Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser
        1555                1560                1565            
 Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Gln Thr Thr Ala Ala
    1570                1575                1580                
 Thr Thr Thr Ala Thr Thr Gly Ser Thr Ala Ile Pro Ser Ser Thr Pro
1585                1590                1595                1600
 Gly Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Gln Ala Thr Thr Pro
                1605                1610                1615    
 Thr Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala
            1620                1625                1630        
 Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr
        1635                1640                1645            
 Ser Phe Thr Pro Ile Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr Ser
    1650                1655                1660                
 Gln Asn Arg Pro Pro His Pro Met Ala Thr Met Ser Thr Ile His Pro
1665                1670                1675                1680
 Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Lys
                1685                1690                1695    
 Ala Thr Thr Thr Arg Ala Thr Ser Ser Met Ser Thr Pro Ser Ser Thr
            1700                1705                1710        
 Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr Thr
        1715                1720                1725            
 Thr Ala Ala Leu Pro His Gly Thr Pro Ser Ser Thr Pro Gly Thr Thr
    1730                1735                1740                
 Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr
1745                1750                1755                1760
 Gly Ser Thr Ala Thr Ala Ser Ser Thr Arg Ala Thr Ala Gly Thr Leu
                1765                1770                1775    
 Lys Val Leu Thr Ser Thr Ala Thr Thr Pro Thr Val Ile Ser Ser Arg
            1780                1785                1790        
 Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu
        1795                1800                1805            
 Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Val Thr Ala Ile Pro
    1810                1815                1820                
 Ser Ser Ser Leu Gly Thr Ala Trp Thr Arg Leu Ser Gln Thr Thr Thr
1825                1830                1835                1840
 Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr
                1845                1850                1855    
 Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Thr Thr Arg Thr
            1860                1865                1870        
 Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr
        1875                1880                1885            
 Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser
    1890                1895                1900                
 Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr Thr
1905                1910                1915                1920
 Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro Gly
                1925                1930                1935    
 Thr Thr His Thr Ala Thr Val Leu Thr Thr Thr Thr Thr Thr Val Ala
            1940                1945                1950        
 Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr
        1955                1960                1965            
 Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser
    1970                1975                1980                
 Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro Val
1985                1990                1995                2000
 Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr Val Thr
                2005                2010                2015    
 Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn Thr
            2020                2025                2030        
 Thr Ala Thr Thr His Gly Arg Ser Leu Pro Pro Ser Ser Pro His Thr
        2035                2040                2045            
 Val Pro Thr Ala Trp Thr Ser Ala Thr Ser Gly Ile Leu Gly Thr Thr
    2050                2055                2060                
 His Ile Thr Glu Pro Ser Thr Gly Thr Ser His Thr Pro Ala Ala Thr
2065                2070                2075                2080
 Thr Gly Thr Thr Gln Pro Ser Thr Pro Ala Leu Ser Ser Pro His Pro
                2085                2090                2095    
 Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro
            2100                2105                2110        
 Gly His Thr Arg Gly Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser
        2115                2120                2125            
 Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Ser Pro Thr Ser Ala Pro
    2130                2135                2140                
 Ile Thr Thr Val Val Thr Thr Gly Cys Glu Pro Gln Cys Ala Trp Ser
2145                2150                2155                2160
 Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp
                2165                2170                2175    
 Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys Glu
            2180                2185                2190        
 Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly Val Pro
        2195                2200                2205            
 Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly Leu
    2210                2215                2220                
 Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe Asn
2225                2230                2235                2240
 Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser Thr
                2245                2250                2255    
 Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr
            2260                2265                2270        
 Trp Ile Leu Thr Lys Leu Thr Thr Thr Ala Thr Thr Thr Glu Ser Thr
        2275                2280                2285            
 Gly Ser Thr Ala Thr Pro Ser Ser Thr Gln Gly Pro Pro Ala Gly Thr
    2290                2295                2300                
 Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys
2305                2310                2315                2320
 Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu
                2325                2330                2335    
 Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro
            2340                2345                2350        
 Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr
        2355                2360                2365            
 Pro Met Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr
    2370                2375                2380                
 Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Thr Thr Gly Ala
2385                2390                2395                2400
 Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr
                2405                2410                2415    
 Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Val Thr Pro Ser
            2420                2425                2430        
 Ser Ser Pro Gly Thr Ala Arg Thr Pro Pro Val Trp Ile Ser Thr Thr
        2435                2440                2445            
 Thr Thr Pro Thr Thr Ser Gly Ser Thr Val Thr Pro Ser Ser Ile Pro
    2450                2455                2460                
 Gly Thr Thr His Thr Pro Thr Val Leu Thr Thr Thr Thr Gln Pro Val
2465                2470                2475                2480
 Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly
                2485                2490                2495    
 Thr Pro Pro Ser Leu Ile Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly
            2500                2505                2510        
 Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro
        2515                2520                2525            
 Glu Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr Val
    2530                2535                2540                
 Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn
2545                2550                2555                2560
 Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro Ser Ser Pro His
                2565                2570                2575    
 Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser Gly Thr Leu Gly Thr
            2580                2585                2590        
 Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His Thr Pro Ala Ala
        2595                2600                2605            
 Thr Thr Gly Thr Thr Thr Thr Ser Thr Pro Ala Leu Ser Ser Pro His
    2610                2615                2620                
 Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr
2625                2630                2635                2640
 Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro
                2645                2650                2655    
 Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Gln Pro Thr Ser Ala
            2660                2665                2670        
 Pro Ile Thr Thr Val Val Thr Thr Gly Cys Glu Pro Gln Cys Ala Trp
        2675                2680                2685            
 Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly
    2690                2695                2700                
 Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys
2705                2710                2715                2720
 Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Thr Ala Gln Pro Gly Val
                2725                2730                2735    
 Pro Leu Gly Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly
            2740                2745                2750        
 Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe
        2755                2760                2765            
 Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser
    2770                2775                2780                
 Thr Pro Ala Thr Ser Ser Thr Ala Met Pro Ser Ser Thr Pro Gly Thr
2785                2790                2795                2800
 Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ser
                2805                2810                2815    
 Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala Pro Pro
            2820                2825                2830        
 Pro Lys Val Leu Thr Ser Pro Ala Thr Thr Pro Thr Ala Thr Ser Ser
        2835                2840                2845            
 Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro Val
    2850                2855                2860                
 Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser Val Thr Pro Ile
2865                2870                2875                2880
 Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr Leu Pro Glu Gln Thr Thr
                2885                2890                2895    
 Thr Pro Val Ala Thr Met Ser Thr Ile His Pro Ser Ser Thr Pro Glu
            2900                2905                2910        
 Thr Thr His Thr Ser Thr Val Leu Thr Thr Lys Ala Thr Thr Arg Ala
        2915                2920                2925            
 Thr Ser Ser Thr Ser Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile
    2930                2935                2940                
 Leu Thr Glu Leu Thr Thr Ala Ala Thr Thr Thr Ala Gly Thr Gly Pro
2945                2950                2955                2960
 Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu
                2965                2970                2975    
 Leu Thr Thr Thr Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr
            2980                2985                2990        
 Leu Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr
        2995                3000                3005            
 Thr Ala Thr Val Thr Ala Pro Pro Gly Ser Thr Ala Thr Ala Ser Ser
    3010                3015                3020                
 Thr Gln Ala Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr
3025                3030                3035                3040
 Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Ser Ser Ser Pro Gly Thr
                3045                3050                3055    
 Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala
            3060                3065                3070        
 Thr Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr
        3075                3080                3085            
 Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr
    3090                3095                3100                
 Pro Ser Ser Thr Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr
3105                3110                3115                3120
 Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser
                3125                3130                3135    
 Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr
            3140                3145                3150        
 Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro
        3155                3160                3165            
 Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Thr Thr Pro Thr
    3170                3175                3180                
 Thr Ser Gly Ser Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His
3185                3190                3195                3200
 Thr Ala Arg Val Leu Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser
                3205                3210                3215    
 Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser
            3220                3225                3230        
 Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn
        3235                3240                3245            
 Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Ser
    3250                3255                3260                
 Met Ala Thr Thr Pro Ala Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser
3265                3270                3275                3280
 Ser Pro Arg Thr Ala Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr
                3285                3290                3295    
 Lys Ser Thr Ala Thr Ser Phe Thr Pro Ile Pro Ser Ser Thr Leu Trp
            3300                3305                3310        
 Thr Thr Trp Thr Val Pro Ala Gln Thr Thr Thr Pro Met Ser Thr Met
        3315                3320                3325            
 Ser Thr Ile His Thr Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr
    3330                3335                3340                
 Val Leu Thr Thr Thr Ala Thr Met Thr Arg Ala Thr Asn Ser Thr Ala
3345                3350                3355                3360
 Thr Pro Ser Ser Thr Leu Gly Thr Thr Arg Ile Leu Thr Glu Leu Thr
                3365                3370                3375    
 Thr Thr Ala Thr Thr Thr Ala Ala Thr Gly Ser Thr Ala Thr Leu Ser
            3380                3385                3390        
 Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Ile Ala
        3395                3400                3405            
 Thr Val Met Val Pro Thr Gly Ser Thr Ala Thr Thr Ser Ser Thr Leu
    3410                3415                3420                
 Gly Thr Ala His Thr Pro Lys Val Val Thr Ala Met Ala Thr Met Pro
3425                3430                3435                3440
 Thr Ala Thr Ala Ser Thr Val Pro Ser Ser Ser Thr Val Gly Thr Thr
                3445                3450                3455    
 Arg Thr Pro Ala Val Leu Pro Ser Ser Leu Pro Thr Phe Ser Val Ser
            3460                3465                3470        
 Thr Val Ser Ser Ser Val Leu Thr Thr Leu Arg Pro Thr Gly Phe Pro
        3475                3480                3485            
 Ser Ser His Phe Ser Thr Pro Cys Phe Cys Arg Ala Phe Gly Gln Phe
    3490                3495                3500                
 Phe Ser Pro Gly Glu Val Ile Tyr Asn Lys Thr Asp Arg Ala Gly Cys
3505                3510                3515                3520
 His Phe Tyr Ala Val Cys Asn Gln His Cys Asp Ile Asp Arg Phe Gln
                3525                3530                3535    
 Gly Ala Cys Pro Thr Ser Pro Pro Pro Val Ser Ser Ala Pro Leu Ser
            3540                3545                3550        
 Ser Pro Ser Pro Ala Pro Gly Cys Asp Asn Ala Ile Pro Leu Arg Gln
        3555                3560                3565            
 Val Asn Glu Thr Trp Thr Leu Glu Asn Cys Thr Val Ala Arg Cys Val
    3570                3575                3580                
 Gly Asp Asn Arg Val Val Leu Leu Asp Pro Lys Pro Val Ala Asn Val
3585                3590                3595                3600
 Thr Cys Val Asn Lys His Leu Pro Ile Lys Val Ser Asp Pro Ser Gln
                3605                3610                3615    
 Pro Cys Asp Phe His Tyr Glu Cys Glu Cys Ile Cys Ser Met Trp Gly
            3620                3625                3630        
 Gly Ser His Tyr Ser Thr Phe Asp Gly Thr Ser Tyr Thr Phe Arg Gly
        3635                3640                3645            
 Asn Cys Thr Tyr Val Leu Met Arg Glu Ile His Ala Arg Phe Gly Asn
    3650                3655                3660                
 Leu Ser Leu Tyr Leu Asp Asn His Tyr Cys Thr Ala Ser Ala Thr Ala
3665                3670                3675                3680
 Ala Ala Ala Arg Cys Pro Ala Ala Leu Ser Ile His Tyr Lys Ser Met
                3685                3690                3695    
 Asp Ile Val Leu Thr Val Thr Met Val His Gly Lys Glu Glu Gly Leu
            3700                3705                3710        
 Ile Leu Phe Asp Gln Ile Pro Val Ser Ser Gly Phe Ser Lys Asn Gly
        3715                3720                3725            
 Val Leu Val Pro Val Leu Gly Thr Thr Thr Met Arg Val Asp Ile Pro
    3730                3735                3740                
 Ala Leu Gly Val Ser Val Thr Phe Asn Gly Gln Val Phe Gln Ala Arg
3745                3750                3755                3760
 Leu Pro Tyr Ser Leu Phe His Asn Asn Thr Glu Gly Gln Cys Gly Thr
                3765                3770                3775    
 Cys Thr Asn Asn Gln Arg Asp Asp Cys Leu Gln Arg Asp Gly Thr Thr
            3780                3785                3790        
 Ala Ala Ser Cys Lys Asp Met Ala Lys Thr Trp Leu Val Pro Asp Ser
        3795                3800                3805            
 Arg Lys Asp Gly Cys Trp Ala Pro Thr Gly Thr Pro Pro Thr Ala Ser
    3810                3815                3820                
 Pro Ala Ala Pro Val Ser Ser Thr Pro Thr Pro Thr Pro Cys Pro Pro
3825                3830                3835                3840
 Gln Pro Leu Cys Asp Leu Met Leu Ser Gln Val Phe Ala Glu Cys His
                3845                3850                3855    
 Asn Leu Val Pro Pro Gly Pro Phe Phe Asn Ala Cys Ile Ser Asp His
            3860                3865                3870        
 Cys Arg Gly Arg Leu Glu Val Pro Cys Gln Ser Leu Glu Ala Tyr Ala
        3875                3880                3885            
 Glu Leu Cys Arg Ala Arg Gly Val Cys Ser Asp Trp Arg Gly Ala Thr
    3890                3895                3900                
 Gly Gly Leu Cys Asp Leu Thr Cys Pro Pro Thr Lys Val Tyr Lys Pro
3905                3910                3915                3920
 Cys Gly Pro Ile Gln Pro Ala Thr Cys Asn Ser Arg Asn Gln Ser Pro
                3925                3930                3935    
 Gln Leu Glu Gly Met Ala Glu Gly Cys Phe Cys Pro Glu Asp Gln Ile
            3940                3945                3950        
 Leu Phe Asn Ala His Met Gly Ile Cys Val Gln Ala Cys Pro Cys Val
        3955                3960                3965            
 Gly Pro Asp Gly Phe Pro Lys Phe Pro Gly Glu Arg Trp Val Ser Asn
    3970                3975                3980                
 Cys Gln Ser Cys Val Cys Asp Glu Gly Ser Val Ser Val Gln Cys Lys
3985                3990                3995                4000
 Pro Leu Pro Cys Asp Ala Gln Gly Gln Pro Pro Pro Cys Asn Arg Pro
                4005                4010                4015    
 Gly Phe Val Thr Val Thr Arg Pro Arg Ala Glu Asn Pro Cys Cys Pro
            4020                4025                4030        
 Glu Thr Val Cys Val Cys Asn Thr Thr Thr Cys Pro Gln Ser Leu Pro
        4035                4040                4045            
 Val Cys Pro Pro Gly Gln Glu Ser Ile Cys Thr Gln Glu Glu Gly Asp
    4050                4055                4060                
 Cys Cys Pro Thr Phe Arg Cys Arg Pro Gln Leu Cys Ser Tyr Asn Gly
4065                4070                4075                4080
 Thr Phe Tyr Gly Val Gly Ala Thr Phe Pro Gly Ala Leu Pro Cys His
                4085                4090                4095    
 Met Cys Thr Cys Leu Ser Gly Asp Thr Gln Asp Pro Thr Val Gln Cys
            4100                4105                4110        
 Gln Glu Asp Ala Cys Asn Asn Thr Thr Cys Pro Gln Gly Phe Glu Tyr
        4115                4120                4125            
 Lys Arg Val Ala Gly Gln Cys Cys Gly Glu Cys Val Gln Thr Ala Cys
    4130                4135                4140                
 Leu Thr Pro Asp Gly Gln Pro Val Gln Leu Asn Glu Thr Trp Val Asn
4145                4150                4155                4160
 Ser His Val Asp Asn Cys Thr Val Tyr Leu Cys Glu Ala Glu Gly Gly
                4165                4170                4175    
 Val His Leu Leu Thr Pro Gln Pro Ala Ser Cys Pro Asp Val Ser Ser
            4180                4185                4190        
 Cys Arg Gly Ser Leu Arg Lys Thr Gly Cys Cys Tyr Ser Cys Glu Glu
        4195                4200                4205            
 Asp Ser Cys Gln Val Arg Ile Asn Thr Thr Ile Leu Trp His Gln Gly
    4210                4215                4220                
 Cys Glu Thr Glu Val Asn Ile Thr Phe Cys Glu Gly Ser Cys Pro Gly
4225                4230                4235                4240
 Ala Ser Lys Tyr Ser Ala Glu Ala Gln Ala Met Gln His Gln Cys Thr
                4245                4250                4255    
 Cys Cys Gln Glu Arg Arg Val His Glu Glu Thr Val Pro Leu His Cys
            4260                4265                4270        
 Pro Asn Gly Ser Ala Ile Leu His Thr Tyr Thr His Val Asp Glu Cys
        4275                4280                4285            
 Gly Cys Thr Pro Phe Cys Val Pro Ala Pro Met Ala Pro Pro His Thr
    4290                4295                4300                
 Arg Gly Phe Pro Ala Gln Glu Ala Thr Ala Val
4305                4310                4315



      <210> 812
      <211> 811
      <212> PRT
      <213> Homo sapiens


      <400> 812
 Met Glu Ser Gln Gly Val Pro Pro Gly Pro Tyr Arg Ala Thr Lys Leu
   1               5                  10                  15    
 Trp Asn Glu Val Thr Thr Ser Phe Arg Ala Gly Met Pro Leu Arg Lys
              20                  25                  30        
 His Arg Gln His Phe Lys Lys Tyr Gly Asn Cys Phe Thr Ala Gly Glu
          35                  40                  45            
 Ala Val Asp Trp Leu Tyr Asp Leu Leu Arg Asn Asn Ser Asn Phe Gly
      50                  55                  60                
 Pro Glu Val Thr Arg Gln Gln Thr Ile Gln Leu Leu Arg Lys Phe Leu
  65                  70                  75                  80
 Lys Asn His Val Ile Glu Asp Ile Lys Gly Arg Trp Gly Ser Glu Asn
                  85                  90                  95    
 Val Asp Asp Asn Asn Gln Leu Phe Arg Phe Pro Ala Thr Ser Pro Leu
             100                 105                 110        
 Lys Thr Leu Pro Arg Arg Tyr Pro Glu Leu Arg Lys Asn Asn Ile Glu
         115                 120                 125            
 Asn Phe Ser Lys Asp Lys Asp Ser Ile Phe Lys Leu Arg Asn Leu Ser
     130                 135                 140                
 Arg Arg Thr Pro Lys Arg His Gly Leu His Leu Ser Gln Glu Asn Gly
 145                 150                 155                 160
 Glu Lys Ile Lys His Glu Ile Ile Asn Glu Asp Gln Glu Asn Ala Ile
                 165                 170                 175    
 Asp Asn Arg Glu Leu Ser Gln Glu Asp Val Glu Glu Val Trp Arg Tyr
             180                 185                 190        
 Val Ile Leu Ile Tyr Leu Gln Thr Ile Leu Gly Val Pro Ser Leu Glu
         195                 200                 205            
 Glu Val Ile Asn Pro Lys Gln Val Ile Pro Gln Tyr Ile Met Tyr Asn
     210                 215                 220                
 Met Ala Asn Thr Ser Lys Arg Gly Val Val Ile Leu Gln Asn Lys Ser
 225                 230                 235                 240
 Asp Asp Leu Pro His Trp Val Leu Ser Ala Met Lys Cys Leu Ala Asn
                 245                 250                 255    
 Trp Pro Arg Ser Asn Asp Met Asn Asn Pro Thr Tyr Val Gly Phe Glu
             260                 265                 270        
 Arg Asp Val Phe Arg Thr Ile Ala Asp Tyr Phe Leu Asp Leu Pro Glu
         275                 280                 285            
 Pro Leu Leu Thr Phe Glu Tyr Tyr Glu Leu Phe Val Asn Ile Leu Val
     290                 295                 300                
 Val Cys Gly Tyr Ile Thr Val Ser Asp Arg Ser Ser Gly Ile His Lys
 305                 310                 315                 320
 Ile Gln Asp Asp Pro Gln Ser Ser Lys Phe Leu His Leu Asn Asn Leu
                 325                 330                 335    
 Asn Ser Phe Lys Ser Thr Glu Cys Leu Leu Leu Ser Leu Leu His Arg
             340                 345                 350        
 Glu Lys Lys Lys Glu Glu Ser Asp Ser Thr Glu Arg Leu Gln Ile Ser
         355                 360                 365            
 Asn Pro Gly Phe Gln Glu Arg Cys Ala Lys Lys Met Gln Leu Val Asn
     370                 375                 380                
 Leu Arg Asn Arg Arg Val Ser Ala Asn Asp Ile Met Gly Gly Ser Cys
 385                 390                 395                 400
 His Asn Leu Ile Gly Leu Ser Asn Met His Asp Leu Ser Ser Asn Ser
                 405                 410                 415    
 Lys Pro Arg Cys Cys Ser Leu Glu Gly Ile Val Asp Val Pro Gly Asn
             420                 425                 430        
 Ser Ser Lys Glu Ala Ser Ser Val Phe His Gln Ser Phe Pro Asn Ile
         435                 440                 445            
 Glu Gly Gln Asn Asn Lys Leu Phe Leu Glu Ser Lys Pro Lys Gln Glu
     450                 455                 460                
 Phe Leu Leu Asn Leu His Ser Glu Glu Asn Ile Gln Lys Pro Phe Ser
 465                 470                 475                 480
 Ala Gly Phe Lys Arg Thr Ser Thr Leu Thr Val Gln Asp Gln Glu Glu
                 485                 490                 495    
 Leu Cys Asn Gly Lys Cys Lys Ser Lys Gln Leu Cys Arg Ser Gln Ser
             500                 505                 510        
 Leu Leu Leu Arg Ser Ser Thr Arg Arg Asn Ser Tyr Ile Asn Thr Pro
         515                 520                 525            
 Val Ala Glu Ile Ile Met Lys Pro Asn Val Gly Gln Gly Ser Thr Ser
     530                 535                 540                
 Val Gln Thr Ala Met Glu Ser Glu Leu Gly Glu Ser Ser Ala Thr Ile
 545                 550                 555                 560
 Asn Lys Arg Leu Cys Lys Ser Thr Ile Glu Leu Ser Glu Asn Ser Leu
                 565                 570                 575    
 Leu Pro Ala Ser Ser Met Leu Thr Gly Thr Gln Ser Leu Leu Gln Pro
             580                 585                 590        
 His Leu Glu Arg Val Ala Ile Asp Ala Leu Gln Leu Cys Cys Leu Leu
         595                 600                 605            
 Leu Pro Pro Pro Asn Arg Arg Lys Leu Gln Leu Leu Met Arg Met Ile
     610                 615                 620                
 Ser Arg Met Ser Gln Asn Val Asp Met Pro Lys Leu His Asp Ala Met
 625                 630                 635                 640
 Gly Thr Arg Ser Leu Met Ile His Thr Phe Ser Arg Cys Val Leu Cys
                 645                 650                 655    
 Cys Ala Glu Glu Val Asp Leu Asp Glu Leu Leu Ala Gly Arg Leu Val
             660                 665                 670        
 Ser Phe Leu Met Asp His His Gln Glu Ile Leu Gln Val Pro Ser Tyr
         675                 680                 685            
 Leu Gln Thr Ala Val Glu Lys His Leu Asp Tyr Leu Lys Lys Gly His
     690                 695                 700                
 Ile Glu Asn Pro Gly Asp Gly Leu Phe Ala Pro Leu Pro Thr Tyr Ser
 705                 710                 715                 720
 Tyr Cys Lys Gln Ile Ser Ala Gln Glu Phe Asp Glu Gln Lys Val Ser
                 725                 730                 735    
 Thr Ser Gln Ala Ala Ile Ala Glu Leu Leu Glu Asn Ile Ile Lys Asn
             740                 745                 750        
 Arg Ser Leu Pro Leu Lys Glu Lys Arg Lys Lys Leu Lys Gln Phe Gln
         755                 760                 765            
 Lys Glu Tyr Pro Leu Ile Tyr Gln Lys Arg Phe Pro Thr Thr Glu Ser
     770                 775                 780                
 Glu Ala Ala Leu Phe Gly Asp Lys Pro Thr Ile Lys Gln Pro Met Leu
 785                 790                 795                 800
 Ile Leu Arg Lys Pro Lys Phe Arg Ser Leu Arg
                 805                 810    



      <210> 813
      <211> 450
      <212> PRT
      <213> Homo sapiens


      <400> 813
 Met Val Val Gln Ala Ala Val Ala Pro Asn Arg Ser Gln Arg Leu Leu
   1               5                  10                  15    
 Leu Lys Ile Pro Tyr Gly Ser Leu Arg Arg Arg Ser Val Glu Arg Met
              20                  25                  30        
 Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu
          35                  40                  45            
 Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu
      50                  55                  60                
 Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala
  65                  70                  75                  80
 Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg
                  85                  90                  95    
 Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr
             100                 105                 110        
 Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn
         115                 120                 125            
 Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys
     130                 135                 140                
 Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr
 145                 150                 155                 160
 Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg
                 165                 170                 175    
 Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu
             180                 185                 190        
 His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys
         195                 200                 205            
 Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser
     210                 215                 220                
 Ile Val Gly Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys
 225                 230                 235                 240
 Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile
                 245                 250                 255    
 Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln
             260                 265                 270        
 Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val
         275                 280                 285            
 Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly
     290                 295                 300                
 His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile
 305                 310                 315                 320
 Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp
                 325                 330                 335    
 Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu
             340                 345                 350        
 Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu
         355                 360                 365            
 Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser
     370                 375                 380                
 Leu Leu Ser Ser Gly Arg Gln Arg Pro Ala Gly Gly Thr Pro Pro Glu
 385                 390                 395                 400
 His Gly Trp Asp Pro Arg Gly Asp Pro Gly Arg Trp Gly Glu Leu Gln
                 405                 410                 415    
 Leu Gly Arg Leu Gln Gly Lys Leu Leu Gln Ser Trp Leu Cys Phe Pro
             420                 425                 430        
 Asp Gln Gly Trp Asp Pro Asn Ala Asn Leu Arg Lys Leu Leu Pro Gly
         435                 440                 445            
 Ile Lys
     450



      <210> 814
      <211> 410
      <212> PRT
      <213> Homo sapiens


      <400> 814
 Met Val Leu Ser Asn Ser Asn Gln Leu Leu Leu Lys Ser Val Thr Gln
   1               5                  10                  15    
 Ala Asp Ala Gly Thr Tyr Thr Cys Arg Ala Ile Val Pro Arg Ile Gly
              20                  25                  30        
 Val Ala Glu Arg Glu Val Pro Leu Tyr Val Asn Gly Pro Pro Ile Ile
          35                  40                  45            
 Ser Ser Glu Ala Val Gln Tyr Ala Val Arg Gly Asp Gly Gly Lys Val
      50                  55                  60                
 Glu Cys Phe Ile Gly Ser Thr Pro Pro Pro Asp Arg Ile Ala Trp Ala
  65                  70                  75                  80
 Trp Lys Glu Asn Phe Leu Glu Val Gly Thr Leu Glu Arg Tyr Thr Val
                  85                  90                  95    
 Glu Arg Thr Asn Ser Gly Ser Gly Val Leu Ser Thr Leu Thr Ile Asn
             100                 105                 110        
 Asn Val Met Glu Ala Asp Phe Gln Thr His Tyr Asn Cys Thr Ala Trp
         115                 120                 125            
 Asn Ser Phe Gly Pro Gly Thr Ala Ile Ile Gln Leu Glu Glu Arg Glu
     130                 135                 140                
 Val Leu Pro Val Gly Ile Ile Ala Gly Ala Thr Ile Gly Ala Ser Ile
 145                 150                 155                 160
 Leu Leu Ile Phe Phe Phe Ile Ala Leu Val Phe Phe Leu Tyr Arg Arg
                 165                 170                 175    
 Arg Lys Gly Ser Arg Lys Asp Val Thr Leu Arg Lys Leu Asp Ile Lys
             180                 185                 190        
 Val Glu Thr Val Asn Arg Glu Pro Leu Thr Met His Ser Asp Arg Glu
         195                 200                 205            
 Asp Asp Thr Ala Ser Val Ser Thr Ala Thr Arg Val Met Lys Ala Ile
     210                 215                 220                
 Tyr Ser Ser Phe Lys Asp Asp Val Asp Leu Lys Gln Asp Leu Arg Cys
 225                 230                 235                 240
 Asp Thr Ile Asp Thr Arg Glu Glu Tyr Glu Met Lys Asp Pro Thr Asn
                 245                 250                 255    
 Gly Tyr Tyr Asn Val Arg Ala His Glu Asp Arg Pro Ser Ser Arg Ala
             260                 265                 270        
 Val Leu Tyr Ala Asp Tyr Arg Ala Pro Gly Pro Ala Arg Phe Asp Gly
         275                 280                 285            
 Arg Pro Ser Ser Arg Leu Ser His Ser Ser Gly Tyr Ala Gln Leu Asn
     290                 295                 300                
 Thr Tyr Ser Arg Gly Pro Ala Ser Asp Tyr Gly Pro Glu Pro Thr Pro
 305                 310                 315                 320
 Pro Gly Pro Ala Ala Pro Ala Gly Thr Asp Thr Thr Ser Gln Leu Ser
                 325                 330                 335    
 Tyr Glu Asn Tyr Glu Lys Phe Asn Ser His Pro Phe Pro Gly Ala Ala
             340                 345                 350        
 Gly Tyr Pro Thr Tyr Arg Leu Gly Tyr Pro Gln Ala Pro Pro Ser Gly
         355                 360                 365            
 Leu Glu Arg Thr Pro Tyr Glu Ala Tyr Asp Pro Ile Gly Lys Tyr Ala
     370                 375                 380                
 Thr Ala Thr Arg Phe Ser Tyr Thr Ser Gln His Ser Asp Tyr Gly Gln
 385                 390                 395                 400
 Arg Phe Gln Gln Arg Met Gln Thr His Val
                 405                 410



      <210> 815
      <211> 143
      <212> PRT
      <213> Homo sapiens


      <400> 815
 Met Leu His Ser Leu Leu Leu His Ser Leu Arg Leu Cys Ala Gln Thr
   1               5                  10                  15    
 Ala Ser Cys Leu Val Leu Phe Pro Arg Phe Leu Gly Thr Ala Phe Met
              20                  25                  30        
 Leu Trp Leu Leu Asp Phe Leu Cys Ile Arg Lys His Phe Leu Gly Arg
          35                  40                  45            
 Arg Arg Arg Gly Lys Pro Glu Pro Glu Val Glu Leu Asn Ser Glu Gly
      50                  55                  60                
 Glu Glu Val Pro Pro Asp Asp Pro Pro Ile Cys Val Ser Asp Asp Asn
  65                  70                  75                  80
 Arg Leu Cys Thr Leu Ala Ser Leu Lys Ala Val Trp His Gly Gln Lys
                  85                  90                  95    
 Leu Asp Phe Phe Lys Gln Ala His Glu Gly Gly Pro Ala Pro Asn Ser
             100                 105                 110        
 Glu Val Val Leu Pro Asp Gly Phe Gln Ser Gln His Ile Leu Asp Tyr
         115                 120                 125            
 Ala Gln Gly Asn Arg Pro Leu Val Leu Asn Phe Gly Ser Cys Thr
     130                 135                 140            



      <210> 816
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 816
 Met Ser Pro Lys Cys Ser Ala Asp Ala Glu Asn Ser Phe Lys Glu Ser
   1               5                  10                  15    
 Met Glu Lys Ser Ser Tyr Ser Asp Trp Leu Ile Asn Asn Ser Ile Ala
              20                  25                  30        
 Glu Leu Val Ala Ser Thr Gly Leu Pro Val Asn Ile Ser Asp Ala Tyr
          35                  40                  45            
 Gln Asp Pro Arg Phe Asp Ala Glu Ala Asp Gln Ile Ser Gly Phe His
      50                  55                  60                
 Ile Arg Ser Val Leu Cys Val Pro Ile Trp Asn Ser Asn His Gln Ile
  65                  70                  75                  80
 Ile Gly Val Ala Gln Val Leu Asn Arg Leu Asp Gly Lys Pro Phe Asp
                  85                  90                  95    
 Asp Ala Asp Gln Arg Leu Phe Glu Ala Phe Val Ile Phe Cys Gly Leu
             100                 105                 110        
 Gly Ile Asn Asn Thr Ile Met Tyr Asp Gln Val Lys Lys Ser Trp Ala
         115                 120                 125            
 Lys Gln Ser Val Ala Leu Asp Val Leu Ser Tyr His Ala Thr Cys Ser
     130                 135                 140                
 Lys Ala Glu Val Asp Lys Phe Lys Ala Ala Asn Ile Pro Leu Val Ser
 145                 150                 155                 160
 Glu Leu Ala Ile Asp Asp Ile His Phe Asp Asp Phe Ser Leu Asp Val
                 165                 170                 175    
 Asp Ala Met Ile Thr Ala Ala Leu Arg Met Phe Met Glu Leu Gly Met
             180                 185                 190        
 Val Gln Lys Phe Lys Ile Asp Tyr Glu Thr Leu Cys Arg Trp Leu Leu
         195                 200                 205            
 Thr Val Arg Lys Asn Tyr Arg Met Val Leu Tyr His Asn Trp Arg His
     210                 215                 220                
 Ala Phe Asn Val Cys Gln Leu Met Phe Ala Met Leu Thr Thr Ala Gly
 225                 230                 235                 240
 Phe Gln Asp Ile Leu Thr Glu Val Glu Ile Leu Ala Val Ile Val Gly
                 245                 250                 255    
 Cys Leu Cys His Asp Leu Asp His Arg Gly Thr Asn Asn Ala Phe Gln
             260                 265                 270        
 Ala Lys Ser Gly Ser Ala Leu Ala Gln Leu Tyr Gly Thr Ser Ala Thr
         275                 280                 285            
 Leu Glu His His His Phe Asn His Ala Val Met Ile Leu Gln Ser Glu
     290                 295                 300                
 Gly His Asn Ile Phe Ala Asn Leu Ser Ser Lys Glu Tyr Ser Asp Leu
 305                 310                 315                 320
 Met Gln Leu Leu Lys Gln Ser Ile Leu Ala Thr Asp Leu Thr Leu Tyr
                 325                 330                 335    
 Phe Glu Arg Arg Thr Glu Phe Phe Glu Leu Val Ser Lys Gly Glu Tyr
             340                 345                 350        
 Asp Trp Asn Ile Lys Asn His Arg Asp Ile Phe Arg Ser Met Leu Met
         355                 360                 365            
 Thr Ala Cys Asp Leu Gly Ala Val Thr Lys Pro Trp Glu Ile Ser Arg
     370                 375                 380                
 Gln Val Ala Glu Leu Val Thr Ser Glu Phe Phe Glu Gln Gly Asp Arg
 385                 390                 395                 400
 Glu Arg Leu Glu Leu Lys Leu Thr Pro Ser Ala Ile Phe Asp Arg Asn
                 405                 410                 415    
 Arg Lys Asp Glu Leu Pro Arg Leu Gln Leu Glu Trp Ile Asp Ser Ile
             420                 425                 430        
 Cys Met Pro Leu Tyr Gln Ala Leu Val Lys Val Asn Val Lys Leu Lys
         435                 440                 445            
 Pro Met Leu Asp Ser Val Ala Thr Asn Arg Ser Lys Trp Glu Glu Leu
     450                 455                 460                
 His Gln Lys Arg Leu Leu Ala Ser Thr Ala Ser Ser Ser Ser Pro Ala
 465                 470                 475                 480
 Ser Val Met Val Ala Lys Glu Asp Arg Asn
                 485                 490



      <210> 817
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 817
 Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp
   1               5                  10                  15    
 Glu Asp Ser Glu Thr Tyr Phe Cys Pro Cys Pro Cys Gly Asp Asn Phe
              20                  25                  30        
 Ser Ile Thr Lys Glu Glu Leu Glu Asn Gly Glu Gly Val Ala Met Cys
          35                  40                  45            
 Pro Gly Cys Ser Leu Ile Ile Lys Val Ile Tyr Asp Lys Asp Gln Phe
      50                  55                  60                
 Ala Cys Gly Glu Thr Val Pro Val Pro Ser Val Asn Lys Glu
  65                  70                  75            



      <210> 818
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 818
 Met Phe Cys Leu Phe His Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp
   1               5                  10                  15    
 His Pro Tyr Leu Glu Pro Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr
              20                  25                  30        
 Cys Ser Glu Gly Ala His Val Ser Cys Tyr Arg Leu His Cys Pro Pro
          35                  40                  45            
 Val His Cys Pro Gln Pro Val Thr Glu Pro Gln Gln Cys Cys Pro Lys
      50                  55                  60                
 Cys Val Glu Pro His Thr Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser
  65                  70                  75                  80
 Cys Gln His Asn Gly Thr Met Tyr Gln His Gly Glu Ile Phe Ser Ala
                  85                  90                  95    
 His Glu Leu Phe Pro Ser Arg Leu Pro Asn Gln Cys Val Leu Cys Ser
             100                 105                 110        
 Cys Thr Glu Gly Gln Ile Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro
         115                 120                 125            
 Gly Cys Pro Ala Pro Leu Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys
     130                 135                 140                
 Lys Asp Glu Ala Ser Glu Gln Ser Asp Glu Glu Asp Ser Val Gln Ser
 145                 150                 155                 160
 Leu His Gly Val Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly
                 165                 170                 175    
 Arg Lys Arg Gly Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro
             180                 185                 190        
 Leu Ser Phe Ile Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr
         195                 200                 205            
 Thr Val Lys Ile Val Leu Lys Glu Lys His Lys Lys Ala Cys Val His
     210                 215                 220                
 Gly Gly Lys Thr Tyr Ser His Gly Glu Val Trp His Pro Ala Phe Arg
 225                 230                 235                 240
 Ala Phe Gly Pro Leu Pro Cys Ile Leu Cys Thr Cys Glu Asp Gly Arg
                 245                 250                 255    
 Gln Asp Cys Gln Arg Val Thr Cys Pro Thr Glu Tyr Pro Cys Arg His
             260                 265                 270        
 Pro Glu Lys Val Ala Gly Lys Cys Cys Lys Ile Cys Pro Glu Asp Lys
         275                 280                 285            
 Ala Asp Pro Gly His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala
     290                 295                 300                
 Pro Gly Arg Val Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn
 305                 310                 315                 320
 Leu Arg Arg Phe Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile
                 325                 330                 335    
 Tyr Leu Trp Lys Leu Val Lys Gly Ile Phe Leu Ala Gln Thr Leu Glu
             340                 345                 350        
 Leu Lys Val Thr Ala Ser Pro Asp Lys Val Thr Lys Thr
         355                 360                 365



      <210> 819
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 819
 Met Leu Val Thr Leu Gln Leu Leu Lys Val Lys Thr Ser His Val Glu
   1               5                  10                  15    
 Asn Asp Tyr Ile Asp Asn Pro Ser Leu Ala Leu Thr Thr Gly Pro Lys
              20                  25                  30        
 Arg Thr Arg Gly Gly Ala Pro Glu Leu Ala Pro Thr Pro Ala Arg Cys
          35                  40                  45            
 Asp Gln Asp Val Thr His His Trp Ile Ser Phe Ser Gly Arg Pro Ser
      50                  55                  60                
 Ser Val Ser Ser Ser Ser Ser Thr Ser Ser Asp Gln Arg Leu Leu Asp
  65                  70                  75                  80
 His Met Ala Pro Pro Pro Val Ala Asp Gln Ala Ser Pro Arg Ala Val
                  85                  90                  95    
 Arg Ile Gln Pro Lys Val Val His Cys Gln Pro Leu Asp Leu Lys Gly
             100                 105                 110        
 Pro Ala Val Pro Pro Glu Leu Asp Lys His Phe Leu Leu Cys Glu Ala
         115                 120                 125            
 Cys Gly Lys Cys Lys Cys Lys Glu Cys Ala Ser Pro Arg Thr Leu Pro
     130                 135                 140                
 Ser Cys Trp Val Cys Asn Gln Glu Cys Leu Cys Ser Ala Gln Thr Leu
 145                 150                 155                 160
 Val Asn Tyr Gly Thr Cys Met Cys Leu Val Gln Gly Ile Phe Tyr His
                 165                 170                 175    
 Cys Thr Asn Glu Asp Asp Glu Gly Ser Cys Ala Asp His Pro Cys Ser
             180                 185                 190        
 Cys Ser Arg Ser Asn Cys Cys Ala Arg Trp Ser Phe Met Gly Ala Leu
         195                 200                 205            
 Ser Val Val Leu Pro Cys Leu Leu Cys Tyr Leu Pro Ala Thr Gly Cys
     210                 215                 220                
 Val Lys Leu Ala Gln Arg Gly Tyr Asp Arg Leu Arg Arg Pro Gly Cys
 225                 230                 235                 240
 Arg Cys Lys His Thr Asn Ser Val Ile Cys Lys Ala Ala Ser Gly Asp
                 245                 250                 255    
 Ala Lys Thr Ser Arg Pro Asp Lys Pro Phe
             260                 265    



      <210> 820
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 820
 Met Ser Gly Arg Glu Gly Lys Cys Ser Gly Thr Val Arg Thr Ala Gly
   1               5                  10                  15    
 Thr Ala Gly Trp Gly Pro Gly Gly Arg Gly Arg Pro Asn Val Leu Val
              20                  25                  30        
 Ser Pro Thr Gly Gly Lys Lys Lys Pro Leu Lys Gln Pro Lys Lys Gln
          35                  40                  45            
 Ala Lys Glu Met Asp Glu Val Arg Ala Gly Ala Glu Ala Leu Ala Gly
      50                  55                  60                
 Ala Gly Ala Leu Gly Asp Arg Pro Glu Leu Asn Thr Leu Cys Leu Ser
  65                  70                  75                  80
 Pro Gly Arg
            



      <210> 821
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 821
 Met Ser Asn Phe Met Lys Pro Gly Lys Gly Ala Leu Val Leu Ala Gly
   1               5                  10                  15    
 His Tyr Ser Gly Arg Lys Ala Gly Ile Val Lys Asn Ile Asp Asp Gly
              20                  25                  30        
 Thr Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg
          35                  40                  45            
 Tyr Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys
      50                  55                  60                
 Arg Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu
  65                  70                  75                  80
 Met Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val
                  85                  90                  95    
 Asn Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg
             100                 105                 110        
 Glu Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Gly Lys
         115                 120                 125            





      <210> 822
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 822
 Met Ala Gly Leu Gly His Leu Ser Leu Leu Gly Gln Asp Glu Thr Gly
   1               5                  10                  15    
 Ala Tyr Leu Ile Asp Arg Asp Pro Thr Tyr Phe Gly Pro Val Leu Asn
              20                  25                  30        
 Tyr Leu Arg His Gly Lys Leu Val Ile Asn Lys Asp Leu Ala Glu Glu
          35                  40                  45            
 Asp Asp Thr Thr Ser Gln Pro Lys Ser Cys Trp Gly Glu Val Ala Leu
      50                  55                  60                





      <210> 823
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 823
 Met Ser Ser Asn Thr His Arg Ala Gln Leu Pro Gly Thr Gly Glu Thr
   1               5                  10                  15    
 Arg Arg Pro Pro Ala Ala Thr Ser Pro Gly Thr Gly His Ser Gln Ser
              20                  25                  30        
 Asp Ser Lys Arg Thr Glu Arg Pro Gln Gln Ser Ser Arg Pro Ser Asn
          35                  40                  45            
 Leu Trp His Leu Ser Gly Asn Ser Ile Pro Ala Asn His Pro Val Pro
      50                  55                  60                
 Gly Arg Ala Ser Pro Gly Arg Ala Ala Thr Glu
  65                  70                  75



      <210> 824
      <211> 78
      <212> PRT
      <213> Homo sapiens


      <400> 824
 Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys
   1               5                  10                  15    
 Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg
              20                  25                  30        
 Ser Arg Lys Glu Ser Tyr Ser Ile Tyr Val Tyr Lys Val Leu Lys Gln
          35                  40                  45            
 Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn
      50                  55                  60                
 Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Leu Pro
  65                  70                  75            



      <210> 825
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 825
 Met Leu Glu Arg Leu Ser Lys Phe Glu Val Gly Asp Ala Glu Asn Val
   1               5                  10                  15    
 Ala Ser Tyr Asp Ser Lys Ile Lys Lys Ile Val His Ser Ile Val Ser
              20                  25                  30        
 Ser Phe Ala Phe Gly Leu Phe Gly Val Phe Leu Val Leu Leu Asp Val
          35                  40                  45            
 Thr Leu Val Leu Ala Asp Leu Ile Phe Thr Asp Ser Lys Leu Tyr Ile
      50                  55                  60                
 Pro Leu Glu Tyr Arg Ser Ile Ser Leu Ala Ile Ala Leu Phe Phe Leu
  65                  70                  75                  80
 Met Asp Val Leu Leu Arg Val Phe Val Glu Gly Ser Thr Pro Pro Pro
                  85                  90                  95    
 Leu His Cys Leu Pro Gly His His Pro Arg
             100                 105    



      <210> 826
      <211> 132
      <212> PRT
      <213> Homo sapiens


      <400> 826
 Met Glu Arg His Ala Gly Leu Leu Val Ser Ala Val Pro Gly Leu Cys
   1               5                  10                  15    
 Leu Ser Trp Arg Arg Arg Pro Gly Ala Arg Gly His Val Pro Gly Gly
              20                  25                  30        
 Pro Gly Gln Gly Pro Ala Gly Arg Val Gly Pro Ser Val Pro Gly Arg
          35                  40                  45            
 Ala Ala Asp Ser Ala Thr Asp Arg Gly Thr Arg Gly Gln Gln Gly His
      50                  55                  60                
 Pro Ser Thr Ala Gly Leu Val Pro Ala Thr Gly Leu Pro Glu Pro Leu
  65                  70                  75                  80
 Arg Glu Ala Ser Thr His Pro Leu Pro Gly Gln Ala Ser Cys His Val
                  85                  90                  95    
 Val Ser Cys Pro Met Glu Arg Pro Thr Gly Lys Glu Thr Glu Gly Ser
             100                 105                 110        
 Leu Gln Pro Thr Leu Ser Glu Glu Leu Arg Pro Ser Val Gln Leu Gln
         115                 120                 125            
 Pro Ala Arg Asn
     130        



      <210> 827
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 827
 Met Asp Ile Phe Tyr Lys Glu Thr Gln Ala Asn Leu Pro Ala Gly Leu
   1               5                  10                  15    
 Cys Ser Thr Leu His Pro Pro Met Glu Asn Lys Ala Glu Gly Thr Gly
              20                  25                  30        
 Val Gln Leu Leu Thr Pro Asp Ser Trp Asn Ile Pro Leu Thr Asp Ala
          35                  40                  45            
 Arg Arg Lys Ala Pro Ser Pro Val Ala Thr Ala Gly Gln Ser Gln Gly
      50                  55                  60                
 Pro Gly Pro Ser Ala Ser Thr Thr Val Ser Pro Ser Asp Thr Ala Asn
  65                  70                  75                  80
 Cys Ser Val Thr Lys Ile Pro Thr Pro Val Pro Lys Ser Ile Pro Ile
                  85                  90                  95    
 Ser Glu Thr Pro Asn Ile Pro Pro Val Ser Val Gln Pro Pro Ala Ser
             100                 105                 110        
 Ile Gly Pro Pro Leu Gly Val Pro Pro Arg Ser Pro Pro Met Val Met
         115                 120                 125            
 Thr Asn Arg Gly Pro Val Pro Leu Pro Ile Phe Met Glu Gln Gln Ile
     130                 135                 140                
 Met Gln Gln Ile Arg Pro Pro Phe Ile Arg Gly Pro Pro His His Ala
 145                 150                 155                 160
 Ser Asn Pro Asn Ser Pro Leu Ser Asn Pro Met Leu Pro Gly Ile Gly
                 165                 170                 175    
 Pro Pro Pro Gly Gly Pro Arg Asn Leu Gly Pro Thr Ser Ser Pro Met
             180                 185                 190        
 His Arg Pro Met Leu Ser Pro His Ile His Pro Pro Ser Thr Pro Thr
         195                 200                 205            
 Met Pro Gly Asn Pro Pro Gly Leu Leu Pro Pro Pro Pro Pro Gly Ala
     210                 215                 220                
 Pro Leu Pro Ser Leu Pro Phe Pro Pro Val Ser Met Met Pro Asn Gly
 225                 230                 235                 240
 Pro Met Pro Val Pro Gln Met Met Asn Phe Gly Leu Pro Ser Leu Ala
                 245                 250                 255    
 Pro Leu Val Pro Pro Pro Thr Leu Leu Val Pro Tyr Pro Val Ile Val
             260                 265                 270        
 Pro Leu Pro Val Pro Ile Pro Ile Pro Ile Pro Ile Pro His Val Ser
         275                 280                 285            
 Asp Ser Lys Pro Pro Lys Lys Leu Leu Ser Pro Glu Glu Pro Ala Val
     290                 295                 300                
 Ser Glu Leu Glu Ser Val Lys Glu Asn Asn Cys Ala Ser Asn Cys His
 305                 310                 315                 320
 Leu Asp Gly Glu Ala Ala Lys Lys Leu Met Gly Glu Glu Ala Leu Ala
                 325                 330                 335    
 Gly Gly Asp Lys Ser Asp Pro Asn Leu Asn Asn Pro Ala Asp Glu Asp
             340                 345                 350        
 His Ala Tyr Ala Leu Arg Met Leu Pro Lys Thr Gly Cys Val Ile Gln
         355                 360                 365            
 Pro Val Pro Lys Pro Ala Glu Lys Ala Ala Met Ala Pro Cys Ile Ile
     370                 375                 380                
 Ser Ser Pro Met Leu Ser Ala Gly Pro Glu Asp Leu Glu Pro Pro Leu
 385                 390                 395                 400
 Lys Arg Arg Cys Leu Arg Ile Arg Asn Gln Asn Lys
                 405                 410        



      <210> 828
      <211> 138
      <212> PRT
      <213> Homo sapiens


      <400> 828
 Met Phe Ser Glu Ser Met Ile Val Phe Ile Tyr Ser Asp Pro Pro Pro
   1               5                  10                  15    
 Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala Thr
              20                  25                  30        
 Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu Ser Lys Met Ala Pro
          35                  40                  45            
 Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His
      50                  55                  60                
 Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu Gln Ile Arg Gly Leu
  65                  70                  75                  80
 Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met Cys Gly Lys Glu Arg
                  85                  90                  95    
 Thr Ser Ala Met Leu Thr Val Arg Gly Lys Gly His Met Gln Pro Ser
             100                 105                 110        
 Ser Thr Met Leu Ser Cys Pro Arg Val Asp Leu Thr Pro Ser Val Ser
         115                 120                 125            
 Gly Cys Leu Met Ser Gly Cys Gln Asp Leu
     130                 135            



      <210> 829
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 829
 Met Ser Ser Gln Gln Ser Ala Val Ser Ala Lys Gly Phe Ser Lys Gly
   1               5                  10                  15    
 Ser Ser Gln Gly Pro Ala Pro Cys Pro Ala Pro Ala Pro Thr Pro Ala
              20                  25                  30        
 Pro Ala Ser Ser Ser Ser Cys Cys Gly Ser Gly Arg Gly Cys Cys Gly
          35                  40                  45            
 Asp Ser Gly Cys Cys Gly Ser Ser Ser Thr Ser Cys Cys Cys Phe Pro
      50                  55                  60                
 Arg Arg Arg Arg Arg Gln Arg Ser Ser Gly Cys Cys Cys Cys Gly Gly
  65                  70                  75                  80
 Gly Ser Gln Arg Ser Gln Arg Ser Asn Asn Arg Ser Ser Gly Cys Cys
                  85                  90                  95    
 Ser Gly Cys
            



      <210> 830
      <211> 525
      <212> PRT
      <213> Homo sapiens


      <400> 830
 Met Ser Cys Ser Ser Arg Ala Ser Ser Ser Arg Ala Gly Gly Ser Ser
   1               5                  10                  15    
 Ser Ala Arg Val Ser Ala Gly Gly Ser Ser Phe Ser Ser Gly Ser Arg
              20                  25                  30        
 Cys Gly Leu Gly Gly Ser Ser Ala Gln Gly Phe Arg Gly Gly Ala Ser
          35                  40                  45            
 Ser Cys Ser Leu Ser Gly Gly Ser Ser Asp Ala Phe Gly Gly Ser Phe
      50                  55                  60                
 Gly Gly Gly Phe Gly Ser Cys Ser Val Gly Gly Gly Phe Gly Gly Ala
  65                  70                  75                  80
 Ser Gly Ser Gly Thr Gly Phe Gly Gly Gly Ser Ser Phe Gly Gly Val
                  85                  90                  95    
 Ser Gly Phe Gly Arg Gly Ser Gly Phe Cys Gly Ser Ser Arg Phe Ser
             100                 105                 110        
 Ser Gly Ala Thr Gly Gly Phe Tyr Ser Tyr Gly Gly Gly Met Gly Gly
         115                 120                 125            
 Gly Val Gly Asp Gly Gly Leu Phe Ser Gly Gly Glu Lys Gln Thr Met
     130                 135                 140                
 Gln Asn Leu Asn Asp Arg Leu Ala Asn Tyr Leu Asp Lys Val Arg Ala
 145                 150                 155                 160
 Leu Glu Glu Ala Asn Thr Asp Leu Glu Asn Lys Ile Lys Glu Trp Tyr
                 165                 170                 175    
 Asp Lys Tyr Gly Pro Gly Ser Gly Asp Gly Gly Ser Gly Arg Asp Tyr
             180                 185                 190        
 Ser Lys Tyr Tyr Ser Ile Ile Glu Asp Leu Arg Asn Gln Ile Ile Ala
         195                 200                 205            
 Ala Thr Val Glu Asn Ala Gly Ile Ile Leu His Ile Asp Asn Ala Arg
     210                 215                 220                
 Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu Cys Leu
 225                 230                 235                 240
 Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Lys Val Leu Asp
                 245                 250                 255    
 Asp Leu Thr Met Thr Arg Ser Asp Leu Glu Met Gln Ile Glu Ser Phe
             260                 265                 270        
 Thr Glu Glu Leu Ala Tyr Leu Arg Lys Asn His Glu Glu Glu Met Lys
         275                 280                 285            
 Asn Met Gln Gly Ser Ser Gly Gly Glu Val Thr Val Glu Met Asn Ala
     290                 295                 300                
 Ala Pro Gly Thr Asp Leu Thr Lys Leu Leu Asn Asp Met Arg Ala Gln
 305                 310                 315                 320
 Tyr Glu Glu Leu Ala Glu Gln Asn Arg Arg Glu Ala Glu Glu Arg Phe
                 325                 330                 335    
 Asn Lys Gln Ser Ala Ser Leu Gln Ala Gln Ile Ser Thr Asp Ala Gly
             340                 345                 350        
 Ala Ala Thr Ser Ala Lys Asn Glu Ile Thr Glu Leu Lys Arg Thr Leu
         355                 360                 365            
 Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala Met Lys Ser Ser
     370                 375                 380                
 Leu Glu Gly Thr Leu Ala Asp Thr Glu Ala Gly Tyr Val Ala Gln Leu
 385                 390                 395                 400
 Ser Glu Ile Gln Thr Gln Ile Ser Ala Leu Glu Glu Glu Ile Cys Gln
                 405                 410                 415    
 Ile Trp Gly Glu Thr Lys Cys Gln Asn Ala Glu Tyr Lys Gln Leu Leu
             420                 425                 430        
 Asp Ile Lys Thr Arg Leu Glu Val Glu Ile Glu Thr Tyr Arg Arg Leu
         435                 440                 445            
 Leu Asp Gly Glu Gly Gly Gly Ser Ser Phe Ala Glu Phe Gly Gly Arg
     450                 455                 460                
 Asn Ser Gly Ser Val Asn Met Gly Ser Arg Asp Leu Val Ser Gly Asp
 465                 470                 475                 480
 Ser Arg Ser Gly Ser Cys Ser Gly Gln Gly Arg Asp Ser Ser Lys Thr
                 485                 490                 495    
 Arg Val Thr Lys Thr Ile Val Glu Glu Leu Val Asp Gly Lys Val Val
             500                 505                 510        
 Ser Ser Gln Val Ser Ser Ile Ser Glu Val Lys Val Lys
         515                 520                 525



      <210> 831
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 831
 Met Pro Pro Gly Leu Ser Leu Pro Pro Pro Phe Ser Leu Pro Arg Pro
   1               5                  10                  15    
 Ser Leu Val Gly Gly Phe Leu Gln Ala Pro Val Pro Ala Gly Ala Gly
              20                  25                  30        
 His Asn Val Pro Thr Pro Arg Val Ser Ala Ser Gln Pro Pro Ala Pro
          35                  40                  45            
 Thr Ala Pro Ala Arg Gln Asn Pro Cys Ala Leu Gly Ala Cys Gly Leu
      50                  55                  60                
 Pro Ser Leu Glu Pro Leu Phe Ser Ser Ala Leu Phe Pro Pro Ala Ser
  65                  70                  75                  80
 Pro Gly Gly Ala Ser Gly Ser His Gly Val Pro Ser Ala Pro Arg Pro
                  85                  90                  95    
 Thr Ala Leu Trp Gly Glu Val Val Gly Cys Ile Val Trp Gly Ser Ala
             100                 105                 110        
 Leu Leu Trp Asp Asn Tyr Thr Ile Tyr Cys Leu Ser
         115                 120                



      <210> 832
      <211> 489
      <212> PRT
      <213> Homo sapiens


      <400> 832
 Met Glu Pro Gly Leu Glu His Ala Leu Arg Arg Thr Pro Ser Trp Ser
   1               5                  10                  15    
 Ser Leu Gly Gly Ser Glu His Gln Glu Met Ser Phe Leu Glu Gln Glu
              20                  25                  30        
 Asn Ser Ser Ser Trp Pro Ser Pro Ala Val Thr Ser Ser Ser Glu Arg
          35                  40                  45            
 Ile Arg Gly Lys Arg Arg Ala Lys Ala Leu Arg Trp Thr Arg Gln Lys
      50                  55                  60                
 Ser Val Glu Glu Gly Glu Pro Pro Gly Gln Gly Glu Gly Pro Arg Ser
  65                  70                  75                  80
 Arg Pro Ala Ala Glu Ser Thr Gly Leu Glu Ala Thr Phe Pro Lys Thr
                  85                  90                  95    
 Thr Pro Leu Ala Gln Ala Asp Pro Ala Gly Val Gly Thr Pro Pro Thr
             100                 105                 110        
 Gly Trp Asp Cys Leu Pro Ser Asp Cys Thr Ala Ser Ala Ala Gly Ser
         115                 120                 125            
 Ser Thr Asp Asp Val Glu Leu Ala Thr Glu Phe Pro Ala Thr Glu Ala
     130                 135                 140                
 Trp Glu Cys Glu Leu Glu Gly Leu Leu Glu Glu Arg Pro Ala Leu Cys
 145                 150                 155                 160
 Leu Ser Pro Gln Ala Pro Phe Pro Lys Leu Gly Trp Asp Asp Glu Leu
                 165                 170                 175    
 Arg Lys Pro Gly Ala Gln Ile Tyr Met Arg Phe Ile Glu Glu His Thr
             180                 185                 190        
 Cys Tyr Asp Ala Met Ala Thr Ser Ser Lys Leu Val Ile Phe Asp Thr
         195                 200                 205            
 Met Leu Glu Ile Lys Lys Ala Phe Phe Ala Leu Val Ala Asn Gly Val
     210                 215                 220                
 Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser Phe Val Gly Met
 225                 230                 235                 240
 Leu Thr Ile Thr Asp Phe Ile Leu Val Leu His Arg Tyr Tyr Arg Ser
                 245                 250                 255    
 Pro Leu Val Gln Ile Tyr Glu Ile Glu Gln His Lys Ile Glu Thr Trp
             260                 265                 270        
 Arg Glu Ile Tyr Leu Gln Gly Cys Phe Lys Pro Leu Val Ser Ile Ser
         275                 280                 285            
 Pro Asn Asp Ser Leu Phe Glu Ala Val Tyr Thr Leu Ile Lys Asn Arg
     290                 295                 300                
 Ile His Arg Leu Pro Val Leu Asp Pro Val Ser Gly Asn Val Leu His
 305                 310                 315                 320
 Ile Leu Thr His Lys Arg Leu Leu Lys Phe Leu His Ile Phe Gly Ser
                 325                 330                 335    
 Leu Leu Pro Arg Pro Ser Phe Leu Tyr Arg Thr Ile Gln Asp Leu Gly
             340                 345                 350        
 Ile Gly Thr Phe Arg Asp Leu Ala Val Val Leu Glu Thr Ala Pro Ile
         355                 360                 365            
 Leu Thr Ala Leu Asp Ile Phe Val Asp Arg Arg Val Ser Ala Leu Pro
     370                 375                 380                
 Val Val Asn Glu Cys Gly Gln Val Val Gly Leu Tyr Ser Arg Phe Asp
 385                 390                 395                 400
 Val Ile His Leu Ala Ala Gln Gln Thr Tyr Asn His Leu Asp Met Ser
                 405                 410                 415    
 Val Gly Glu Ala Leu Arg Gln Arg Thr Leu Cys Leu Glu Gly Val Leu
             420                 425                 430        
 Ser Cys Gln Pro His Glu Ser Leu Gly Glu Val Ile Asp Arg Ile Ala
         435                 440                 445            
 Arg Glu Gln Val His Arg Leu Val Leu Val Asp Glu Thr Gln His Leu
     450                 455                 460                
 Leu Gly Val Val Ser Leu Ser Asp Ile Leu Gln Ala Leu Val Leu Ser
 465                 470                 475                 480
 Pro Ala Gly Ile Asp Ala Leu Gly Ala
                 485                



      <210> 833
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 833
 Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys
   1               5                  10                  15    
 Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys
              20                  25                  30        
 Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser
          35                  40                  45            
 Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Gly Cys Ser Ser Gly Gly
      50                  55                  60                
 Gly Gly Cys Cys Leu Ser His His Arg Arg His Arg Ser His Arg His
  65                  70                  75                  80
 Arg Leu Gln Ser Ser Gly Cys Cys Ser Gln Pro Ser Gly Gly Ser Ser
                  85                  90                  95    
 Cys Cys Gly Gly Asp Ser Gly Gln His Ser Gly Gly Cys Cys
             100                 105                 110



      <210> 834
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 834
 Met Gly Cys Ser Gly Cys Ser Gly Gly Cys Gly Ser Ser Cys Gly Gly
   1               5                  10                  15    
 Cys Gly Ser Ser Cys Gly Gly Cys Gly Ser Gly Tyr Gly Gly Cys Gly
              20                  25                  30        
 Ser Gly Cys Cys Val Pro Val Cys Cys Cys Lys Pro Val Cys Cys Cys
          35                  40                  45            
 Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys
      50                  55                  60                
 Gly Val Cys Gly Ser Cys Gly Gly Cys Lys Gly Gly Cys Gly Ser Cys
  65                  70                  75                  80
 Gly Gly Ser Lys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Val Cys
                  85                  90                  95    
 Cys Ser Ser Ser Cys Gly Ser Cys Gly Gly Ser Lys Gly Val Cys Gly
             100                 105                 110        
 Phe Arg Gly Gly Ser Lys Gly Gly Cys Gly Ser Tyr Gly Cys Ser Gln
         115                 120                 125            
 Ser Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser
     130                 135                 140                
 Cys Cys Gln Ser Ser Cys Cys Lys Pro Tyr Cys Cys Gln Ser Ser Cys
 145                 150                 155                 160
 Cys Lys Pro Cys Ser Cys Phe Ser Gly Cys Gly Ser Ser Cys Cys Gln
                 165                 170                 175    
 Ser Ser Cys Tyr Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys Val Pro
             180                 185                 190        
 Val Cys Cys Gln Cys Lys Ile
         195                



      <210> 835
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 835
 Met Ser Ser Gln Gln Gln Gln Arg Gln Gln Gln Gln Cys Pro Pro Gln
   1               5                  10                  15    
 Arg Ala Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Val
              20                  25                  30        
 Lys Cys Gln Glu Thr Cys Ala Pro Lys Thr Lys Asp Pro Cys Ala Pro
          35                  40                  45            
 Gln Val Lys Lys Gln Cys Pro Pro Lys Gly Thr Ile Ile Pro Ala Gln
      50                  55                  60                
 Gln Lys Cys Pro Ser Ala Gln Gln Ala Ser Lys Ser Lys Gln Lys
  65                  70                  75                



      <210> 836
      <211> 509
      <212> PRT
      <213> Homo sapiens


      <400> 836
 Met Thr Val Thr Tyr Thr Ala Arg Val Ala Asn Ala Arg Phe Gly Gly
   1               5                  10                  15    
 Phe Ser Gln Leu Leu Leu Leu Trp Arg Gly Ser Ile Tyr Lys Leu Leu
              20                  25                  30        
 Trp Arg Glu Leu Leu Cys Phe Leu Gly Phe Tyr Met Ala Leu Ser Ala
          35                  40                  45            
 Ala Tyr Arg Phe Val Leu Thr Glu Gly Gln Lys Arg Tyr Phe Glu Lys
      50                  55                  60                
 Leu Val Ile Tyr Cys Asp Gln Tyr Ala Ser Leu Ile Pro Val Ser Phe
  65                  70                  75                  80
 Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Ser Gln
                  85                  90                  95    
 Tyr Leu Cys Met Pro Leu Pro Asp Ala Leu Met Cys Val Val Ala Gly
             100                 105                 110        
 Thr Val His Gly Arg Asp Asp Arg Gly Arg Leu Tyr Arg Arg Thr Leu
         115                 120                 125            
 Met Arg Tyr Ala Gly Leu Ser Ala Val Leu Ile Leu Arg Ser Val Ser
     130                 135                 140                
 Thr Ala Val Phe Lys Arg Phe Pro Thr Ile Asp His Val Val Glu Ala
 145                 150                 155                 160
 Gly Phe Met Thr Arg Glu Glu Arg Lys Lys Phe Glu Asn Leu Asn Ser
                 165                 170                 175    
 Ser Tyr Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Ser Asn Leu Ala
             180                 185                 190        
 Ala Gln Ala Arg Arg Glu Gly Arg Ile Arg Asp Asn Ser Ala Leu Lys
         195                 200                 205            
 Leu Leu Leu Glu Glu Leu Asn Val Phe Arg Gly Lys Cys Gly Met Leu
     210                 215                 220                
 Phe His Tyr Asp Trp Ile Ser Val Pro Leu Val Tyr Thr Gln Val Val
 225                 230                 235                 240
 Thr Ile Ala Leu Tyr Ser Tyr Phe Leu Ala Cys Leu Ile Gly Arg Gln
                 245                 250                 255    
 Phe Leu Asp Pro Ala Gln Gly Tyr Lys Asp His Asp Leu Asp Leu Cys
             260                 265                 270        
 Val Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu
         275                 280                 285            
 Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp
     290                 295                 300                
 Phe Glu Thr Asn Phe Leu Ile Asp Arg Asn Phe Gln Val Ser Met Leu
 305                 310                 315                 320
 Ala Val Asp Glu Met Tyr Asp Asp Leu Ala Val Leu Glu Lys Asp Leu
                 325                 330                 335    
 Tyr Trp Asp Ala Ala Glu Ala Arg Ala Pro Tyr Thr Ala Ala Thr Val
             340                 345                 350        
 Phe Gln Leu Arg Gln Pro Ser Phe Gln Gly Ser Thr Phe Asp Ile Thr
         355                 360                 365            
 Leu Ala Lys Glu Asp Met Gln Phe Gln Arg Leu Asp Gly Leu Asp Gly
     370                 375                 380                
 Pro Met Gly Gly Ala Pro Gly Asp Phe Leu Gln Arg Leu Leu Pro Ala
 385                 390                 395                 400
 Gly Ala Gly Met Val Ala Gly Gly Pro Leu Gly Arg Arg Leu Ser Phe
                 405                 410                 415    
 Leu Leu Arg Lys Asn Ser Cys Val Ser Glu Ala Ser Thr Gly Ala Ser
             420                 425                 430        
 Cys Ser Cys Ala Val Val Pro Glu Gly Ala Ala Pro Glu Cys Ser Cys
         435                 440                 445            
 Gly Asp Pro Leu Leu Asp Pro Gly Leu Pro Glu Pro Glu Ala Pro Pro
     450                 455                 460                
 Pro Ala Gly Pro Glu Pro Leu Thr Leu Ile Pro Gly Pro Val Glu Pro
 465                 470                 475                 480
 Phe Ser Ile Val Thr Met Pro Gly Pro Arg Gly Pro Ala Pro Pro Trp
                 485                 490                 495    
 Leu Pro Ser Pro Ile Gly Glu Glu Glu Glu Asn Leu Ala
             500                 505                



      <210> 837
      <211> 153
      <212> PRT
      <213> Homo sapiens


      <400> 837
 Met Pro Tyr Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met
   1               5                  10                  15    
 Phe Gln Tyr Tyr Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln
              20                  25                  30        
 Gln Thr Val Pro Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu
          35                  40                  45            
 Glu Gln Ile Pro Phe Tyr Ala Gln Phe Gly Tyr Ile Pro Gln Leu Ala
      50                  55                  60                
 Glu Pro Ala Ile Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln
  65                  70                  75                  80
 Leu Gly Thr Ala Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile
                  85                  90                  95    
 Pro Tyr Leu Gln Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly
             100                 105                 110        
 Val Phe Met Pro Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe
         115                 120                 125            
 Thr Ser Ala Val Asp Gln Thr Ile Thr Pro Glu Leu Pro Glu Glu Lys
     130                 135                 140                
 Asp Lys Thr Asp Ser Leu Arg Glu Pro
 145                 150            



      <210> 838
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 838
 Met Trp Asn Ser Pro Leu Leu Arg Lys Thr Ala Glu Leu Leu Val Ser
   1               5                  10                  15    
 Leu Trp Lys Arg Ser Gln Pro Cys Glu Val Pro Ser Pro Pro Leu Ile
              20                  25                  30        
 Phe Pro Val Cys Asp Ile Ile Val Tyr Pro Pro Thr Pro Val Pro Ser
          35                  40                  45            
 Asp Met Ser Cys Leu Leu Pro Gly Trp His Arg Phe Asn Gly Thr
      50                  55                  60            



      <210> 839
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 839
 Met Phe Ser Glu Ser Met Ile Val Phe Ile Tyr Ser Asp Pro Pro Pro
   1               5                  10                  15    
 Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala Thr
              20                  25                  30        
 Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu Ser Lys Met Ala Pro
          35                  40                  45            
 Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His
      50                  55                  60                
 Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu Gln Ile Arg Gly Leu
  65                  70                  75                  80
 Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met Cys Gly Lys Glu Arg
                  85                  90                  95    
 Thr Ser Ala Met Leu Thr Val Arg Gly Lys Gly His Met Gln Pro Ser
             100                 105                 110        
 Ser Thr Met Leu Ser Cys Pro Arg Val Asp Leu Thr Pro Ser Val Ser
         115                 120                 125            
 Ala Tyr Ala Ala Phe Ser Pro His Val Cys Ala Cys Leu Cys Asn Cys
     130                 135                 140                
 Thr Ser Phe Phe Gln Pro Pro Gly Leu Leu
 145                 150                



      <210> 840
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 840
 Met Leu Val Thr Ile Trp Ala Met Val Ala Thr Ala Val Leu Pro Leu
   1               5                  10                  15    
 Leu Thr Ala Val Leu Gly Val Thr Val Val Thr Arg Arg Asp Thr Glu
              20                  25                  30        
 Gly Pro Gly Arg Ala Ala Leu Val His Leu Thr Gly Ser Pro Arg Gln
          35                  40                  45            
 Lys Val Gly Thr Ser Gly Arg Glu Gly Leu Pro Gly Leu Gly Ala Ser
      50                  55                  60                
 Cys Ala Glu Ser Glu Leu Glu Arg Glu Thr Gln Glu Pro Arg Ser Arg
  65                  70                  75                  80
 Gly Arg Cys Arg Phe Gly Ala Ala Arg Trp Arg Gln Val Pro Leu Ala
                  85                  90                  95    
 Ser Pro Gln Arg Pro Phe Leu Leu Ser Pro Gly Pro Arg Leu His Arg
             100                 105                 110        
 Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly
         115                 120                 125            
 Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg
     130                 135                 140                
 Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg Arg Gln Arg
 145                 150                 155                 160
 Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Ser Leu Leu Arg
                 165                 170                 175    
 Arg Thr His Leu Cys Ser Leu Ser Lys Ser Asp Thr Arg Leu His Glu
             180                 185                 190        
 Leu His Arg Gly Pro Arg Ser Ser Arg Ala Leu Arg Pro Ala Ser Met
         195                 200                 205            
 Asp Leu Leu Arg Pro His Trp Leu Glu Val Ser Arg Asp Ile Thr Gly
     210                 215                 220                
 Pro Gln Ala Ala Pro Ser Ala Phe Pro His Gln Glu Leu Pro Arg Ala
 225                 230                 235                 240
 Leu Pro Ala Ala Ala Ala Thr Ala Gly Cys Ala Gly Leu Glu Ala Thr
                 245                 250                 255    
 Tyr Ser Asn Val Gly Leu Ala Ala Leu Pro Gly Val Ser Leu Ala Ala
             260                 265                 270        
 Ser Pro Val Val Ala Glu Tyr Ala Arg Val Gln Lys Arg Lys Gly Thr
         275                 280                 285            
 His Arg Ser Pro Gln Glu Pro Gln Gln Gly Lys Thr Glu Val Thr Pro
     290                 295                 300                
 Ala Ala Gln Val Asp Val Leu Tyr Ser Arg Val Cys Lys Pro Lys Arg
 305                 310                 315                 320
 Arg Asp Pro Gly Pro Thr Thr Asp Pro Leu Asp Pro Lys Gly Gln Gly
                 325                 330                 335    
 Ala Ile Leu Ala Leu Ala Gly Asp Leu Ala Tyr Gln Thr Leu Pro Leu
             340                 345                 350        
 Arg Ala Leu Asp Val Asp Ser Gly Pro Leu Glu Asn Val Tyr Glu Ser
         355                 360                 365            
 Ile Arg Glu Leu Gly Asp Pro Ala Gly Arg Ser Ser Thr Cys Gly Ala
     370                 375                 380                
 Gly Thr Pro Pro Ala Ser Ser Cys Pro Ser Leu Gly Arg Gly Trp Arg
 385                 390                 395                 400
 Pro Leu Pro Ala Ser Leu Pro
                 405        



      <210> 841
      <211> 959
      <212> PRT
      <213> Homo sapiens


      <400> 841
 Met Thr Glu Tyr Glu Leu Leu Ile Gln Ile Ser Asp Ser Val His Tyr
   1               5                  10                  15    
 Thr Glu Gly Ala Leu Val Val Arg Val Leu Asp Val Asn Asp Asn Pro
              20                  25                  30        
 Pro Val Phe Ser Gln Asp Phe Tyr Gln Val Thr Val Pro Glu Ser Ile
          35                  40                  45            
 Pro Val Gly Tyr Ser Val Leu Thr Leu Ser Ala Thr Asp Leu Glu Ser
      50                  55                  60                
 Asn Glu Asn Ile Ser Tyr Arg Ile Leu Ser Ser Ser Lys Glu Phe Ser
  65                  70                  75                  80
 Ile Asp Pro Lys Asn Gly Thr Ile Phe Thr Ile Ser Pro Val Leu Leu
                  85                  90                  95    
 Leu Asp Thr Ile Ser Thr Thr Arg Phe Leu Val Glu Ala Ser Asp Gly
             100                 105                 110        
 Gly Asn Pro Asp Pro Arg Ala Leu Thr Leu Val Glu Ile Gly Ile Glu
         115                 120                 125            
 Asp Met Asn Asn Tyr Ala Pro Glu Phe Thr Val Lys Ser Tyr Asn Leu
     130                 135                 140                
 Ser Leu Ser Glu Asp Ala Leu Val Gly Ser Thr Leu Val Thr Phe Ser
 145                 150                 155                 160
 Asn Ile Asp His Asp Trp Thr Arg Glu Asn Thr Tyr Val Glu Tyr Ser
                 165                 170                 175    
 Ile Ile Ser Gly Asn Ser Gln Asn Asn Phe His Val Glu Thr Lys Phe
             180                 185                 190        
 Phe His Ser Glu Tyr Pro Tyr Lys Gln Val Gly Tyr Leu Val Leu Leu
         195                 200                 205            
 His Ser Leu Asp Arg Glu Ala Ser Ala Ser His Glu Leu Val Ile Leu
     210                 215                 220                
 Ala Ser Asp Ser Gly Cys Pro Pro Leu Ser Ser Thr Ala Val Ile Ser
 225                 230                 235                 240
 Ile Gln Val Leu Asp Val Asn Asp Asn Pro Pro Asn Phe Ser Ser Leu
                 245                 250                 255    
 Ser Tyr His Thr His Val Lys Glu Ser Thr Pro Leu Gly Ser His Ile
             260                 265                 270        
 Thr Val Val Ser Ala Asn Asp Arg Asp Thr Gly Ser His Ala Glu Ile
         275                 280                 285            
 Ile Tyr Asn Ile Ile Ser Gly Asn Glu Lys Gly His Phe Tyr Leu Glu
     290                 295                 300                
 Glu Asn Thr Gly Val Leu Tyr Leu Ile Lys Pro Leu Asp Tyr Glu Lys
 305                 310                 315                 320
 Met Thr Lys Phe Thr Leu Thr Val Gln Ala Ser Asp Ala Glu Lys Lys
                 325                 330                 335    
 His Phe Ser Phe Ala Val Val Phe Val Ser Val Leu Asp Asp Asn Asp
             340                 345                 350        
 His Ala Pro Gln Phe Met Phe Ser Ser Phe Ser Cys Ile Val Pro Glu
         355                 360                 365            
 Asn Leu Pro Ile Ser Ser Thr Ile Cys Ser Ile Asn Ala Leu Asp Phe
     370                 375                 380                
 Asp Ala Gly Pro Tyr Gly Glu Leu Thr Tyr Ser Ile Val Ser Pro Cys
 385                 390                 395                 400
 Phe Leu Thr His Gly Met Ser Tyr Asp His Asp Leu Phe Leu Ile Asp
                 405                 410                 415    
 Pro Leu Thr Gly Asp Ile His Ala Lys Gln Ile Leu Asp Tyr Glu Asn
             420                 425                 430        
 Gly Asn Lys Tyr Cys Leu Thr Val Gln Ala Lys Asp Lys Gly Asp Ala
         435                 440                 445            
 Thr Ala Ser Leu Val Val Trp Val Asp Ile Glu Gly Ile Asp Glu Phe
     450                 455                 460                
 Glu Pro Ile Phe Thr Gln Asp Gln Tyr Phe Phe Thr Leu Pro Glu Lys
 465                 470                 475                 480
 Asn Lys Asp Arg Gln Leu Ile Gly Arg Val Glu Ala Ser Asp Ala Asp
                 485                 490                 495    
 Ala Gly Ile Asp Gly Val Ile Leu Tyr Ser Leu Gly Thr Ser Ser Pro
             500                 505                 510        
 Phe Phe Ser Val Asn Arg Thr Asn Gly Asn Ile Tyr Leu Ile Arg Ala
         515                 520                 525            
 Leu Pro Leu Ile Lys Ser Gln Leu Asn Lys Glu Asp Thr Leu Glu Met
     530                 535                 540                
 Lys Ile Ile Ala His Ser Pro Lys Ser Asp Ser Lys Phe Ala Ser Cys
 545                 550                 555                 560
 Thr Val Phe Val Asn Val Ser Phe Ser Ser Glu Gly Thr Pro Leu Ala
                 565                 570                 575    
 Val Phe Ala Ser Ser Phe Ser Ile Ser Leu Val Val Ser Phe Leu Val
             580                 585                 590        
 Phe Leu Ile Leu Ile Cys Ile Leu Ile Val Met Ile Leu Arg His Lys
         595                 600                 605            
 Gln Lys Asp Thr Ile Asn Asn Tyr Glu Glu Lys Lys Thr Ser Ser Leu
     610                 615                 620                
 Asp Ala Asp Leu Arg Val Thr Arg Asp Ala Ser Val Leu Lys Ala Phe
 625                 630                 635                 640
 Gln Lys Thr Asp Asp Cys Ser Asn Glu Val Val Pro Val Asp Ala Thr
                 645                 650                 655    
 Pro Glu Trp Leu Ser Leu Ile Ser Ile Met Glu Lys Asp Ile Val Asn
             660                 665                 670        
 Leu Tyr Arg Tyr Ser Asn Ser Ser Gly His Cys Ser Val Glu Gly Glu
         675                 680                 685            
 Thr Ala Glu Asp Lys Glu Ile Gln Arg Ile Asn Glu His Pro Tyr Arg
     690                 695                 700                
 Lys Cys Ser Asp Ser Ala Leu Ser Asp His Glu Ser Arg Val Pro Asp
 705                 710                 715                 720
 Ser Gly Ile Pro Arg Asp Ser Asp Gln Leu Ser Cys Leu Ser Gly Glu
                 725                 730                 735    
 Thr Asp Val Met Val Thr Ala Glu Thr Ala Glu Ala Ser Gln Thr Phe
             740                 745                 750        
 Gly Glu Gly Asp Gln Gly Glu Gly Cys Ser Thr Thr Cys Ala Gln Asn
         755                 760                 765            
 Asn Val Leu Pro Gln Thr Val Gln Lys Arg Glu Ala Lys Glu Ser Ile
     770                 775                 780                
 Leu Ala Asp Val Arg Lys Glu Ser Val Phe Ile Ser Gly Asp Gln Glu
 785                 790                 795                 800
 Val Arg Cys Ala Ala Leu Ser Thr Gln Thr Thr Ser Asp His Asp Gly
                 805                 810                 815    
 Lys Asp Asn Tyr His Trp Asn Tyr Leu Leu Ser Trp Glu Pro Lys Phe
             820                 825                 830        
 Gln Pro Leu Ala Ser Val Phe Asn Asp Ile Ala Lys Leu Lys Asp Glu
         835                 840                 845            
 His Leu His Met Pro Gly Ile Pro Lys Glu Lys Lys Ser Phe Val Phe
     850                 855                 860                
 Pro Pro Pro Leu Ile Thr Ala Val Ala Gln Pro Gly Ile Lys Ala Val
 865                 870                 875                 880
 Pro Pro Arg Met Pro Ala Val Asn Leu Gly Gln Val Pro Pro Lys His
                 885                 890                 895    
 Pro Arg Ser Pro Ile Pro Tyr His Leu Gly Ser Leu Pro Glu Gly Met
             900                 905                 910        
 Thr Pro Asn Phe Ser Pro Ser Leu Ser Leu Leu Thr Met Gln Pro Pro
         915                 920                 925            
 Ala Leu Ser Pro Leu Leu Arg Glu Gly Glu Leu Leu Gly Thr His Ile
     930                 935                 940                
 Ser Gly Thr Cys His Glu Leu Lys Ala Glu Asp Glu Val Gln Ile
 945                 950                 955                



      <210> 842
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 842
 Met Ser Phe Ser Glu Gln Gln Cys Lys Gln Pro Cys Val Pro Pro Pro
   1               5                  10                  15    
 Cys Leu Pro Lys Thr Gln Glu Gln Cys Gln Ala Lys Ala Glu Glu Val
              20                  25                  30        
 Cys Leu Pro Thr Cys Gln His Pro Cys Gln Asp Lys Cys Leu Val Gln
          35                  40                  45            
 Ala Gln Glu Val Cys Leu Ser Gln Cys Gln Glu Ser Ser Gln Glu Lys
      50                  55                  60                
 Cys Pro Gln Gln Gly Gln Glu Pro Tyr Leu Pro Pro Cys Gln Asp Gln
  65                  70                  75                  80
 Cys Pro Pro Gln Cys Ala Glu Pro Cys Gln Glu Leu Phe Gln Thr Lys
                  85                  90                  95    
 Cys Val Glu Val Cys Pro Gln Lys Val Gln Glu Lys Cys Ser Ser Pro
             100                 105                 110        
 Gly Lys Gly Lys
         115    



      <210> 843
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 843
 Met Ala Gln Glu Leu Gly Met Gln Cys Gln Ala Arg Gly Ile Leu Gln
   1               5                  10                  15    
 Gln Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly
              20                  25                  30        
 Thr Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu
          35                  40                  45            
 Gly Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn
      50                  55                  60                
 Gly Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu
  65                  70                  75                  80
 Ser Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser
                  85                  90                  95    
 Phe Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu
             100                 105                 110        
 Gln Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Ser Ser Gly Thr
         115                 120                 125            
 Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val Leu Ala Ser
     130                 135                 140                
 Glu Tyr Tyr Arg Gln Asp Arg Leu Tyr Phe Lys Gly Cys Trp Cys Ser
 145                 150                 155                 160
 Cys Leu Arg Asp Lys Gly Arg
                 165        



      <210> 844
      <211> 605
      <212> PRT
      <213> Homo sapiens


      <400> 844
 Met Val Glu Gly Pro Gly Cys Thr Leu Asn Gly Glu Lys Ile Arg Ala
   1               5                  10                  15    
 Arg Val Leu Pro Gly Gln Ala Val Thr Gly Val Arg Gly Ser Ala Leu
              20                  25                  30        
 Arg Ser Leu Gln Gly Arg Ala Leu Arg Leu Ala Ala Ser Thr Val Val
          35                  40                  45            
 Val Ser Pro Gln Ala Ala Ala Leu Asn Asn Asp Ser Ser Gln Asn Val
      50                  55                  60                
 Leu Ser Leu Phe Asn Gly Tyr Val Tyr Ser Gly Val Glu Thr Leu Gly
  65                  70                  75                  80
 Lys Glu Leu Phe Met Tyr Phe Gly Pro Lys Ala Leu Arg Ile His Phe
                  85                  90                  95    
 Gly Met Lys Gly Phe Ile Met Ile Asn Pro Leu Glu Tyr Lys Tyr Lys
             100                 105                 110        
 Asn Gly Ala Ser Pro Val Leu Glu Val Gln Leu Thr Lys Asp Leu Ile
         115                 120                 125            
 Cys Phe Phe Asp Ser Ser Val Glu Leu Arg Asn Ser Met Glu Ser Gln
     130                 135                 140                
 Gln Arg Ile Arg Met Met Lys Glu Leu Asp Val Cys Ser Pro Glu Phe
 145                 150                 155                 160
 Ser Phe Leu Arg Ala Glu Ser Glu Val Lys Lys Gln Lys Gly Arg Met
                 165                 170                 175    
 Leu Gly Asp Val Leu Met Asp Gln Asn Val Leu Pro Gly Val Gly Asn
             180                 185                 190        
 Ile Ile Lys Asn Glu Ala Leu Phe Asp Ser Gly Leu His Pro Ala Val
         195                 200                 205            
 Lys Val Cys Gln Leu Thr Asp Glu Gln Ile His His Leu Met Lys Met
     210                 215                 220                
 Ile Arg Asp Phe Ser Ile Leu Phe Tyr Arg Cys Arg Lys Ala Gly Leu
 225                 230                 235                 240
 Ala Leu Ser Lys His Tyr Lys Val Tyr Lys Arg Pro Asn Cys Gly Gln
                 245                 250                 255    
 Cys His Cys Arg Ile Thr Val Cys Arg Phe Gly Asp Asn Asn Arg Met
             260                 265                 270        
 Thr Tyr Phe Cys Pro His Cys Gln Lys Glu Asn Pro Gln His Val Asp
         275                 280                 285            
 Ile Cys Lys Leu Pro Thr Arg Asn Thr Ile Ile Ser Trp Thr Ser Ser
     290                 295                 300                
 Arg Val Asp His Val Met Asp Ser Val Ala Arg Lys Ser Glu Glu His
 305                 310                 315                 320
 Trp Thr Cys Val Val Cys Thr Leu Ile Asn Lys Pro Ser Ser Lys Ala
                 325                 330                 335    
 Cys Asp Ala Cys Leu Thr Ser Arg Pro Ile Asp Ser Val Leu Lys Ser
             340                 345                 350        
 Glu Glu Asn Ser Thr Val Phe Ser His Leu Met Lys Tyr Pro Cys Asn
         355                 360                 365            
 Thr Phe Gly Lys Pro His Thr Glu Val Lys Ile Asn Arg Lys Thr Ala
     370                 375                 380                
 Phe Gly Thr Thr Thr Leu Val Leu Thr Asp Phe Ser Asn Lys Ser Ser
 385                 390                 395                 400
 Thr Leu Glu Arg Lys Thr Lys Gln Asn Gln Ile Leu Asp Glu Glu Phe
                 405                 410                 415    
 Gln Asn Ser Pro Pro Ala Ser Val Cys Leu Asn Asp Ile Gln His Pro
             420                 425                 430        
 Ser Lys Lys Thr Thr Asn Asp Ile Thr Gln Leu Ser Ser Lys Val Asn
         435                 440                 445            
 Ile Ser Pro Thr Ile Ser Ser Glu Ser Lys Leu Phe Ser Pro Ala His
     450                 455                 460                
 Lys Lys Pro Lys Thr Ala His Tyr Ser Ser Pro Glu Leu Lys Ser Cys
 465                 470                 475                 480
 Asn Pro Gly Tyr Ser Asn Ser Glu Leu Gln Ile Asn Met Thr Asp Gly
                 485                 490                 495    
 Pro Arg Thr Leu Asn Pro Asp Ser Pro Arg Cys Ser Lys His Asn Arg
             500                 505                 510        
 Leu Cys Ile Leu Arg Val Val Arg Lys Asp Gly Glu Asn Lys Gly Arg
         515                 520                 525            
 Gln Phe Tyr Ala Cys Pro Leu Pro Arg Glu Ala Gln Cys Gly Phe Phe
     530                 535                 540                
 Glu Trp Ala Asp Leu Ser Phe Pro Phe Cys Asn His Gly Lys Arg Ser
 545                 550                 555                 560
 Thr Met Lys Thr Val Leu Lys Ile Gly Pro Asn Asn Gly Lys Asn Phe
                 565                 570                 575    
 Phe Val Cys Pro Leu Gly Lys Glu Lys Gln Cys Asn Phe Phe Gln Trp
             580                 585                 590        
 Ala Glu Asn Gly Pro Gly Ile Lys Ile Ile Pro Gly Cys
         595                 600                 605



      <210> 845
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 845
 Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile
   1               5                  10                  15    
 Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly
              20                  25                  30        
 Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu
          35                  40                  45            
 Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile
      50                  55                  60                
 Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Ile Ala Ser Leu Ile
  65                  70                  75                  80
 Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr
                  85                  90                  95    
 Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Ala Phe Arg Arg Arg
             100                 105                 110        
 Cys
    



      <210> 846
      <211> 382
      <212> PRT
      <213> Homo sapiens


      <400> 846
 Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr
   1               5                  10                  15    
 Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu
              20                  25                  30        
 Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val
          35                  40                  45            
 Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His
      50                  55                  60                
 Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu
  65                  70                  75                  80
 Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro
                  85                  90                  95    
 Cys Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser
             100                 105                 110        
 Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr
         115                 120                 125            
 Pro Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala
     130                 135                 140                
 Val Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe
 145                 150                 155                 160
 Val Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Tyr Lys Phe Asp Glu
                 165                 170                 175    
 Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu
             180                 185                 190        
 Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val
         195                 200                 205            
 Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp
     210                 215                 220                
 Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn
 225                 230                 235                 240
 Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu
                 245                 250                 255    
 Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile
             260                 265                 270        
 Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly
         275                 280                 285            
 Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg
     290                 295                 300                
 Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys
 305                 310                 315                 320
 Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met
                 325                 330                 335    
 Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln
             340                 345                 350        
 Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala
         355                 360                 365            
 Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn
     370                 375                 380        



      <210> 847
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 847
 Met Thr Asp Asp Glu Ser Glu Ser Val Leu Ser Asp Ser His Glu Gly
   1               5                  10                  15    
 Ser Glu Leu Glu Leu Pro Val Ile Gln Leu Cys Gly Leu Val Glu Glu
              20                  25                  30        
 Leu Ser Tyr Val Asn Ser Ala Leu Lys Thr Glu Thr Glu Met Phe Glu
          35                  40                  45            
 Lys Tyr Tyr Ala Lys Leu Glu Pro Arg Asp Gln Arg Pro Pro Arg Leu
      50                  55                  60                
 Ser Glu Ile Lys Ile Ser Ala Ala Asp Tyr Ala Gln Phe Arg Gly Arg
  65                  70                  75                  80
 Arg Arg Ser Lys Ser Arg Thr Gly Met Asp Arg Gly Val Gly Leu Thr
                  85                  90                  95    
 Ala Asp Gln Lys Leu Glu Leu Val Gln Lys Glu Val Ala Asp Met Lys
             100                 105                 110        
 Asp Asp Leu Arg His Thr Arg Ala Asn Ala Glu Arg Asp Leu Gln His
         115                 120                 125            
 His Glu Ala Ile Ile Glu Glu Ala Glu Ile Arg Trp Ser Glu Val Ser
     130                 135                 140                
 Arg Glu Val His Glu Phe Glu Lys Asp Ile Leu Lys Ala Ile Ser Lys
 145                 150                 155                 160
 Lys Lys Gly Ser Ile Leu Ala Thr Gln Lys Val Met Lys Tyr Ile Glu
                 165                 170                 175    
 Asp Met Asn Arg Arg Arg Asp Asn Met Lys Glu Asn Tyr Val
             180                 185                 190



      <210> 848
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 848
 Met Gln Ala Leu Arg His Val Val Cys Ala Leu Ser Gly Gly Val Asp
   1               5                  10                  15    
 Ser Ala Val Ala Ala Leu Leu Leu Arg Arg Arg Gly Tyr Gln Val Thr
              20                  25                  30        
 Gly Val Phe Met Lys Asn Trp Asp Ser Leu Asp Glu His Gly Val Cys
          35                  40                  45            
 Thr Ala Asp Lys Asp Cys Glu Asp Ala Tyr Arg Val Cys Gln Ile Leu
      50                  55                  60                
 Asp Ile Pro Phe His Gln Val Ser Tyr Val Lys Glu Tyr Trp Asn Asp
  65                  70                  75                  80
 Val Phe Ser Asp Phe Leu Asn Glu Tyr Glu Lys Gly Arg Thr Pro Asn
                  85                  90                  95    
 Pro Asp Ile Val Cys Asn Lys His Ile Lys Phe Ser Cys Phe Phe His
             100                 105                 110        
 Tyr Ala Val Asp Asn Leu Gly Ala Asp Ala Ile Ala Thr Gly His Tyr
         115                 120                 125            
 Ala Arg Thr Ser Leu Glu Asp Glu Glu Val Phe Glu Gln Lys His Val
     130                 135                 140                
 Lys Lys Pro Glu Gly Leu Phe Arg Asn Arg Phe Glu Val Arg Asn Ala
 145                 150                 155                 160
 Arg Phe Pro Arg Met Pro
                 165    



      <210> 849
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 849
 Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr
   1               5                  10                  15    
 Thr Cys Cys Arg Thr Thr Cys Trp Lys Pro Thr Thr Val Thr Thr Cys
              20                  25                  30        
 Ser Ser Thr Pro Cys Cys Gln Pro Ser Cys Cys Val Ser Ser Cys Cys
          35                  40                  45            
 Gln Pro Cys Cys Arg Pro Ala Cys Cys Gln Asn Thr Cys Cys Arg Thr
      50                  55                  60                
 Thr Cys Cys Gln Pro Thr Cys Leu Thr Ser Cys Cys Gln Pro Ser Cys
  65                  70                  75                  80
 Cys Ser Thr Thr Cys Cys Gln Pro Ile Cys Cys Gly Ser Ser Cys Cys
                  85                  90                  95    
 Gly Gln Thr Ser Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys Ala
             100                 105                 110        
 Pro Val Tyr Cys Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys Leu
         115                 120                 125            
 Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Ser Cys Cys Gln Pro Cys
     130                 135                 140                
 Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys Phe
 145                 150                 155                 160
 Gln Pro Thr Cys Val Ser Ser Cys Cys Gln Pro Ser Cys Cys
                 165                 170                



      <210> 850
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 850
 Met Ser Lys Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr
   1               5                  10                  15    
 Pro Thr Thr Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser
              20                  25                  30        
 Val Ile Thr Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg
          35                  40                  45            
 His Ser Asp Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn
      50                  55                  60                
 Tyr Glu Phe Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala
  65                  70                  75                  80
 Thr Leu Ile Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr
                  85                  90                  95    
 Leu Asn Glu Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg
             100                 105                 110        
 Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu
         115                 120                 125            
 His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr
     130                 135                 140                
 Val Asp Glu Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly
 145                 150                 155                 160
 Ser Pro Thr Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala
                 165                 170                 175    
 Ala Leu Asn Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro
             180                 185                 190        
 Leu Leu Ser Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu
         195                 200                 205            
 Gln Ala Val His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser
     210                 215                 220                
 Asn Gly Asn Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser
 225                 230                 235                 240
 Ile His Val Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro
                 245                 250                 255    
 Met Ser Leu Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp
             260                 265                 270        
 Arg Glu Ile Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu
         275                 280                 285



      <210> 851
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 851
 Met Cys His Thr Ser Cys Ser Ser Gly Cys Gln Pro Ala Cys Cys Ala
   1               5                  10                  15    
 Pro Ser Pro Cys Gln Pro Ala Cys Cys Val Pro Ser Ser Cys Gln Ala
              20                  25                  30        
 Ser Cys Cys Val Pro Val Gly Cys Gln Ser Ser Val Cys Val Pro Val
          35                  40                  45            
 Ser Phe Lys Pro Ala Val Cys Leu Pro Val Ser Cys Gln Ser Ser Val
      50                  55                  60                
 Cys Val Pro Met Ser Phe Lys Ser Ala Val Cys Val Pro Val Ser Cys
  65                  70                  75                  80
 Gln Ser Ser Val Cys Val Pro Val Ser Cys Arg Pro Ile Val Cys Ala
                  85                  90                  95    
 Ala Pro Ser Cys Gln Ser Ser Leu Cys Val Pro Val Ser Cys Arg Pro
             100                 105                 110        
 Val Val Tyr Ala Ala Pro Ser Cys Gln Ser Ser Gly Cys Cys Gln Pro
         115                 120                 125            
 Ser Cys Thr Ser Val Pro Cys Arg Pro Ile Ser Tyr Ser Ile Ser Ser
     130                 135                 140                
 Cys Cys
 145    



      <210> 852
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 852
 Met Asn Ile Gly Met Met Ala Arg Arg Thr Gln Glu Thr Arg Ala Glu
   1               5                  10                  15    
 Ala Gln Thr His Ala Pro Arg Pro Pro Leu Ser Tyr Val Pro Asp Phe
              20                  25                  30        
 Ser Asp Thr Thr Val Val Pro Pro Phe Val Thr Pro Pro Pro Ala Pro
          35                  40                  45            
 Gly Pro Ala Pro Ala Arg Leu Arg Leu Arg Pro Glu Trp Gly Ser His
      50                  55                  60                
 Arg Leu Pro Arg Leu Asp Pro Arg Arg Ala Gly Pro Trp Ala Thr Pro
  65                  70                  75                  80
 Pro Val Pro Pro Ala Thr Ala Ala Lys Pro Gly Ala Pro Leu Gln Pro
                  85                  90                  95    
 Val Leu His Leu Ala Ala Arg Asn Arg Pro Val Pro Ala Ser Pro Arg
             100                 105                 110        
 Val Phe Leu Ser Pro Phe Thr Lys Ser Pro Met Leu Val Ala Arg Arg
         115                 120                 125            
 Arg Cys Ala Gly Gly Gly Asp Ala Ala Val Asn Pro Glu Asp Gly Pro
     130                 135                 140                
 Leu Pro Phe Gln Arg
 145                



      <210> 853
      <211> 36
      <212> PRT
      <213> Homo sapiens


      <400> 853
 Met Ser Arg Ile Asn Lys Tyr Leu Phe Ser Asn Ser Asp Ser Asn Phe
   1               5                  10                  15    
 Ser His Phe Ser Val Ser Asn Val Ser Thr Tyr Cys Val Pro Gly Asn
              20                  25                  30        
 Lys Asp Thr Asn
          35    



      <210> 854
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 854
 Met Ala Pro Phe Val Arg Asn Leu Val Glu Lys Thr Pro Ala Leu Val
   1               5                  10                  15    
 Asn Ala Ala Val Thr Tyr Leu Lys Pro Arg Leu Ala Ala Phe Trp Tyr
              20                  25                  30        
 Tyr Thr Thr Val Glu Leu Val Pro Pro Thr Pro Ala Glu Ile Pro Arg
          35                  40                  45            
 Ala Ile Gln Ser Leu Lys Lys Ile Val Ser Ser Ala Gln Thr Gly Ser
      50                  55                  60                
 Phe Lys Gln Leu Thr Val Lys Glu Ala Leu Leu Asn Gly Leu Val Ala
  65                  70                  75                  80
 Thr Glu Val Ser Thr Trp Phe Tyr Val Arg Glu Ile Thr Gly Lys Arg
                  85                  90                  95    
 Gly Ile Ile Gly
             100



      <210> 855
      <211> 795
      <212> PRT
      <213> Homo sapiens


      <400> 855
 Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly
   1               5                  10                  15    
 Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu
              20                  25                  30        
 Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe
          35                  40                  45            
 Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp
      50                  55                  60                
 Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser
  65                  70                  75                  80
 Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg
                  85                  90                  95    
 Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met
             100                 105                 110        
 Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser
         115                 120                 125            
 Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp
     130                 135                 140                
 Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu
 145                 150                 155                 160
 Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser
                 165                 170                 175    
 Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly
             180                 185                 190        
 Leu Val Ile Leu Gly Gln Tyr Cys Glu Trp Lys Arg Cys Tyr Arg Tyr
         195                 200                 205            
 Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His
     210                 215                 220                
 Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met
 225                 230                 235                 240
 Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu
                 245                 250                 255    
 Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser
             260                 265                 270        
 Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser
         275                 280                 285            
 Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr
     290                 295                 300                
 Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu
 305                 310                 315                 320
 Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser
                 325                 330                 335    
 Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp
             340                 345                 350        
 His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp
         355                 360                 365            
 Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly
     370                 375                 380                
 Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln
 385                 390                 395                 400
 Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile
                 405                 410                 415    
 Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His
             420                 425                 430        
 Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys
         435                 440                 445            
 Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys
     450                 455                 460                
 Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln
 465                 470                 475                 480
 Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly
                 485                 490                 495    
 Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly
             500                 505                 510        
 Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val
         515                 520                 525            
 Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly
     530                 535                 540                
 Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg
 545                 550                 555                 560
 Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala
                 565                 570                 575    
 Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala
             580                 585                 590        
 Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met
         595                 600                 605            
 Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn
     610                 615                 620                
 Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu
 625                 630                 635                 640
 His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu
                 645                 650                 655    
 Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys
             660                 665                 670        
 Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile
         675                 680                 685            
 Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu
     690                 695                 700                
 Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val
 705                 710                 715                 720
 Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys
                 725                 730                 735    
 Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys
             740                 745                 750        
 Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly
         755                 760                 765            
 Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr
     770                 775                 780                
 Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr
 785                 790                 795



      <210> 856
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 856
 Met Ala Phe Glu Glu Leu Leu Ser Gln Val Gly Gly Leu Gly Arg Phe
   1               5                  10                  15    
 Gln Met Leu His Leu Val Phe Ile Leu Pro Ser Leu Met Leu Leu Ile
              20                  25                  30        
 Pro His Ile Leu Leu Glu Asn Phe Ala Ala Ala Ile Pro Gly His Arg
          35                  40                  45            
 Cys Trp Val His Met Leu Asp Asn Asn Thr Gly Ser Gly Asn Glu Thr
      50                  55                  60                
 Gly Ile Leu Ser Glu Asp Ala Leu Leu Arg Ile Ser Ile Pro Leu Asp
  65                  70                  75                  80
 Ser Asn Leu Arg Pro Glu Lys Cys Arg Arg Phe Val His Pro Gln Trp
                  85                  90                  95    
 Gln Leu Leu His Leu Asn Gly Thr Ile His Ser Thr Ser Glu Ala Asp
             100                 105                 110        
 Thr Glu Pro Cys Val Asp Gly Trp Val Tyr Asp Gln Ser Tyr Phe Pro
         115                 120                 125            
 Ser Thr Ile Val Thr Lys Leu Asp Leu Val Cys Asp Tyr Gln Ser Leu
     130                 135                 140                
 Lys Ser Val Val Gln Phe Leu Leu Leu Thr Gly Met Leu Val Gly Gly
 145                 150                 155                 160
 Ile Ile Gly Gly His Val Ser Asp Arg Trp Leu Val Glu Ser Ala Arg
                 165                 170                 175    
 Trp Leu Ile Ile Thr Asn Lys Leu Asp Glu Gly Leu Lys Ala Leu Arg
             180                 185                 190        
 Lys Val Ala Arg Thr Asn Gly Ile Lys Asn Ala Glu Glu Thr Leu Asn
         195                 200                 205            
 Ile Glu Val Val Arg Ser Thr Met Gln Glu Glu Leu Asp Ala Ala Gln
     210                 215                 220                
 Thr Lys Thr Thr Val Cys Asp Leu Phe Arg Asn Pro Ser Met Arg Lys
 225                 230                 235                 240
 Arg Ile Cys Ile Leu Val Phe Leu Arg Lys Lys Asn Leu Lys Glu Lys
                 245                 250                 255    
 Ala
    



      <210> 857
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 857
 Met Met Gly Glu Val Glu Glu Pro Leu Ser Ala Cys Gly Gly Ala Ser
   1               5                  10                  15    
 Val Leu Ala Val Leu Met Ala Pro Ser Ser Trp Gly Ser Leu Ser Ser
              20                  25                  30        
 Gly Pro Ala Ser Pro Ala Arg Pro Ser Cys Leu Leu Gly Ala Arg Gly
          35                  40                  45            
 Ala Ser Pro Gly Gln Ser Leu Cys Leu Gly Pro Ala Ser Leu Ala Ala
      50                  55                  60                
 Leu Pro Pro Ala Met Gly Gly Arg Arg Gly Gly Ser Arg Pro Val Leu
  65                  70                  75                  80
 Val Phe Ala Glu Leu Leu Val Asp
                  85            



      <210> 858
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 858
 Met Lys Gly Ser Arg Ala Leu Leu Leu Val Ala Leu Thr Leu Phe Cys
   1               5                  10                  15    
 Ile Cys Arg Met Ala Thr Gly Glu Asp Asn Asp Glu Phe Phe Met Asp
              20                  25                  30        
 Phe Leu Gln Thr Leu Leu Val Gly Thr Pro Glu Glu Leu Tyr Glu Gly
          35                  40                  45            
 Thr Leu Gly Lys Tyr Asn Val Asn Glu Asp Ala Lys Ala Ala Met Thr
      50                  55                  60                
 Glu Leu Lys Ser Cys Arg Asp Gly Leu Gln Pro Met His Lys Ala Glu
  65                  70                  75                  80
 Leu Val Lys Leu Leu Val Gln Val Leu Gly Ser Gln Asp Gly Ala
                  85                  90                  95



      <210> 859
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 859
 Met Pro Val Pro Lys Pro Leu Thr Ala Trp Gln Leu Leu Leu Pro Asn
   1               5                  10                  15    
 Ser Trp Asn Pro Glu Gln Pro His Lys Phe Arg Leu Leu Cys Trp Ile
              20                  25                  30        
 Lys Arg Pro Ser Gln Arg Ala Leu Arg His Gln Thr Ser Lys Arg Lys
          35                  40                  45            
 Thr Pro Ser Trp Ile Gln Pro Arg Ala Glu Ser Ser Asp Gly Pro Ile
      50                  55                  60                
 Ser Arg Tyr Tyr Leu Thr Thr Thr Thr
  65                  70            



      <210> 860
      <211> 325
      <212> PRT
      <213> Homo sapiens


      <400> 860
 Met Thr Ala Ser Ser Val Leu Leu His Thr Gly Gln Lys Met Pro Leu
   1               5                  10                  15    
 Ile Gly Leu Gly Thr Trp Lys Ser Glu Pro Gly Gln Val Lys Ala Ala
              20                  25                  30        
 Ile Lys His Ala Leu Ser Ala Gly Tyr Arg His Ile Asp Cys Ala Ser
          35                  40                  45            
 Val Tyr Gly Asn Glu Thr Glu Ile Gly Glu Ala Leu Lys Glu Ser Val
      50                  55                  60                
 Gly Ser Gly Lys Ala Val Pro Arg Glu Glu Leu Phe Val Thr Ser Lys
  65                  70                  75                  80
 Leu Trp Asn Thr Lys His His Pro Glu Asp Val Glu Pro Ala Leu Arg
                  85                  90                  95    
 Lys Thr Leu Ala Asp Leu Gln Leu Glu Tyr Leu Asp Leu Tyr Leu Met
             100                 105                 110        
 His Trp Pro Tyr Ala Phe Glu Arg Gly Asp Asn Pro Phe Pro Lys Asn
         115                 120                 125            
 Ala Asp Gly Thr Val Arg Tyr Asp Ser Thr His Tyr Lys Glu Thr Trp
     130                 135                 140                
 Lys Ala Leu Glu Val Leu Val Ala Lys Gly Leu Val Lys Ala Leu Gly
 145                 150                 155                 160
 Leu Ser Asn Phe Asn Ser Arg Gln Ile Asp Asp Val Leu Ser Val Ala
                 165                 170                 175    
 Ser Val Arg Pro Ala Val Leu Gln Val Glu Cys His Pro Tyr Leu Ala
             180                 185                 190        
 Gln Asn Glu Leu Ile Ala His Cys His Ala Arg Gly Leu Glu Val Thr
         195                 200                 205            
 Ala Tyr Ser Pro Leu Gly Ser Ser Asp Arg Ala Trp Arg His Pro Asp
     210                 215                 220                
 Glu Pro Val Leu Leu Glu Glu Pro Val Val Leu Ala Leu Ala Glu Lys
 225                 230                 235                 240
 His Gly Arg Ser Pro Ala Gln Ile Leu Leu Arg Trp Gln Val Gln Arg
                 245                 250                 255    
 Lys Val Ile Cys Ile Pro Lys Ser Ile Asn Pro Ser Arg Ile Leu Gln
             260                 265                 270        
 Asn Ile Gln Val Phe Asp Phe Thr Phe Ser Pro Glu Glu Met Lys Gln
         275                 280                 285            
 Leu Asp Ala Leu Asn Lys Asn Trp Arg Tyr Ile Val Pro Met Ile Thr
     290                 295                 300                
 Val Asp Gly Lys Arg Val Pro Arg Asp Ala Gly His Pro Leu Tyr Pro
 305                 310                 315                 320
 Phe Asn Asp Pro Tyr
                 325



      <210> 861
      <211> 1173
      <212> PRT
      <213> Homo sapiens


      <400> 861
 Met Ala Val Glu Thr Leu Ser Pro Asp Trp Glu Phe Asp Arg Val Asp
   1               5                  10                  15    
 Asp Gly Ser Gln Lys Ile His Ala Glu Val Gln Leu Lys Asn Tyr Gly
              20                  25                  30        
 Lys Phe Leu Glu Glu Tyr Thr Ser Gln Leu Arg Arg Ile Glu Asp Ala
          35                  40                  45            
 Leu Asp Asp Ser Ile Gly Asp Val Trp Asp Phe Asn Leu Asp Pro Ile
      50                  55                  60                
 Ala Leu Lys Leu Leu Pro Tyr Glu Gln Ser Ser Leu Leu Glu Leu Ile
  65                  70                  75                  80
 Lys Thr Glu Asn Lys Val Leu Asn Lys Val Ile Thr Val Tyr Ala Ala
                  85                  90                  95    
 Leu Cys Cys Glu Ile Lys Lys Leu Lys Tyr Glu Ala Glu Thr Lys Phe
             100                 105                 110        
 Tyr Asn Gly Leu Leu Phe Tyr Gly Glu Gly Ala Thr Asp Ala Ser Met
         115                 120                 125            
 Val Glu Gly Asp Cys Gln Ile Gln Met Gly Arg Phe Ile Ser Phe Leu
     130                 135                 140                
 Gln Glu Leu Ser Cys Phe Val Thr Arg Cys Tyr Glu Val Val Met Asn
 145                 150                 155                 160
 Val Val His Gln Leu Ala Ala Leu Tyr Ile Ser Asn Lys Ile Ala Pro
                 165                 170                 175    
 Lys Ile Ile Glu Thr Thr Gly Val His Phe Gln Thr Met Tyr Glu His
             180                 185                 190        
 Leu Gly Glu Leu Leu Thr Val Leu Leu Thr Leu Asp Glu Ile Ile Asp
         195                 200                 205            
 Asn His Ile Thr Leu Lys Asp His Trp Thr Met Tyr Lys Arg Leu Leu
     210                 215                 220                
 Lys Ser Val His His Asn Pro Ser Lys Phe Gly Ile Gln Glu Glu Lys
 225                 230                 235                 240
 Leu Lys Pro Phe Glu Lys Phe Leu Leu Lys Leu Glu Gly Gln Leu Leu
                 245                 250                 255    
 Asp Gly Met Ile Phe Gln Ala Cys Ile Glu Gln Gln Phe Asp Ser Leu
             260                 265                 270        
 Asn Gly Gly Val Ser Val Ser Lys Asn Ser Thr Phe Ala Glu Glu Phe
         275                 280                 285            
 Ala His Ser Ile Arg Ser Ile Phe Ala Asn Val Glu Ala Lys Leu Gly
     290                 295                 300                
 Glu Pro Ser Glu Ile Asp Gln Arg Asp Lys Tyr Val Gly Ile Cys Gly
 305                 310                 315                 320
 Leu Phe Val Leu His Phe Gln Ile Phe Arg Thr Ile Asp Lys Lys Phe
                 325                 330                 335    
 Tyr Lys Ser Leu Leu Asp Ile Cys Lys Lys Val Pro Ala Ile Thr Leu
             340                 345                 350        
 Thr Ala Asn Ile Ile Trp Phe Pro Asp Asn Phe Leu Ile Gln Lys Ile
         355                 360                 365            
 Pro Ala Ala Ala Lys Leu Leu Asp Arg Lys Ser Leu Gln Ala Ile Lys
     370                 375                 380                
 Ile His Arg Asp Thr Phe Leu Gln Gln Lys Ala Gln Ser Leu Thr Lys
 385                 390                 395                 400
 Asp Val Gln Ser Tyr Tyr Val Phe Val Ser Ser Trp Met Met Lys Met
                 405                 410                 415    
 Glu Ser Ile Leu Ser Lys Glu Gln Arg Met Asp Lys Phe Ala Glu Asp
             420                 425                 430        
 Leu Thr Asn Arg Cys Asn Val Phe Ile Gln Gly Phe Leu Tyr Ala Tyr
         435                 440                 445            
 Ser Ile Ser Thr Ile Ile Lys Thr Thr Met Asn Leu Tyr Met Ser Met
     450                 455                 460                
 Gln Lys Pro Met Thr Lys Thr Ser Val Lys Ala Leu Cys Arg Leu Val
 465                 470                 475                 480
 Glu Leu Leu Lys Ala Ile Glu His Met Phe Tyr Arg Arg Ser Met Val
                 485                 490                 495    
 Val Ala Asp Ser Val Ser His Ile Thr Gln His Leu Gln His Gln Ala
             500                 505                 510        
 Leu His Ser Ile Ser Val Ala Lys Lys Arg Val Ile Ser Asp Lys Lys
         515                 520                 525            
 Tyr Ser Glu Gln Arg Leu Asp Val Leu Ser Ala Leu Val Leu Ala Glu
     530                 535                 540                
 Asn Thr Leu Asn Gly Pro Ser Thr Lys Gln Arg Arg Leu Ile Val Ser
 545                 550                 555                 560
 Leu Ala Leu Ser Val Gly Thr Gln Met Lys Thr Phe Lys Asp Glu Glu
                 565                 570                 575    
 Leu Phe Pro Leu Gln Val Val Met Lys Lys Leu Asp Leu Ile Ser Glu
             580                 585                 590        
 Leu Arg Glu Arg Val Gln Thr Gln Cys Asp Cys Cys Phe Leu Tyr Trp
         595                 600                 605            
 His Arg Ala Val Phe Pro Ile Tyr Leu Asp Asp Val Tyr Glu Asn Ala
     610                 615                 620                
 Val Asp Ala Ala Arg Leu His Tyr Met Phe Ser Ala Leu Arg Asp Cys
 625                 630                 635                 640
 Val Pro Ala Met Met His Ala Arg His Leu Glu Ser Tyr Glu Ile Leu
                 645                 650                 655    
 Leu Asp Cys Tyr Asp Lys Glu Ile Met Glu Ile Leu Asn Glu His Leu
             660                 665                 670        
 Leu Asp Lys Leu Cys Lys Glu Ile Glu Lys Asp Leu Arg Leu Ser Val
         675                 680                 685            
 His Thr His Leu Lys Leu Asp Asp Arg Asn Pro Phe Lys Val Gly Met
     690                 695                 700                
 Lys Asp Leu Ala Leu Phe Phe Ser Leu Asn Pro Ile Arg Phe Phe Asn
 705                 710                 715                 720
 Arg Phe Ile Asp Ile Arg Ala Tyr Val Thr His Tyr Leu Asp Lys Thr
                 725                 730                 735    
 Phe Tyr Asn Leu Thr Thr Val Ala Leu His Asp Trp Ala Thr Tyr Ser
             740                 745                 750        
 Glu Met Arg Asn Leu Ala Thr Gln Arg Tyr Gly Leu Val Met Thr Glu
         755                 760                 765            
 Ala His Leu Pro Ser Gln Thr Leu Glu Gln Gly Leu Asp Val Leu Glu
     770                 775                 780                
 Ile Met Arg Asn Ile His Ile Phe Val Ser Arg Tyr Leu Tyr Asn Leu
 785                 790                 795                 800
 Asn Asn Gln Ile Phe Ile Glu Arg Thr Ser Asn Asn Lys His Leu Asn
                 805                 810                 815    
 Thr Ile Asn Ile Arg His Ile Ala Asn Ser Ile Arg Thr His Gly Thr
             820                 825                 830        
 Gly Ile Met Asn Thr Thr Val Asn Phe Thr Tyr Gln Phe Leu Lys Lys
         835                 840                 845            
 Lys Phe Tyr Ile Phe Ser Gln Phe Met Tyr Asp Glu His Ile Lys Ser
     850                 855                 860                
 Arg Leu Ile Lys Asp Ile Arg Phe Phe Arg Glu Ile Lys Asp Gln Asn
 865                 870                 875                 880
 Asp His Lys Tyr Pro Phe Asp Arg Ala Glu Lys Phe Asn Arg Gly Ile
                 885                 890                 895    
 Arg Lys Leu Gly Ile Thr Pro Glu Gly Gln Ser Tyr Leu Asp Gln Phe
             900                 905                 910        
 Arg Gln Leu Ile Ser Gln Ile Gly Asn Ala Met Gly Tyr Val Arg Met
         915                 920                 925            
 Ile Arg Ser Gly Gly Leu His Cys Ser Ser Asn Ala Ile Arg Phe Val
     930                 935                 940                
 Pro Asp Leu Glu Asp Ile Val Asn Phe Glu Glu Leu Val Lys Glu Glu
 945                 950                 955                 960
 Gly Leu Ala Glu Glu Thr Leu Lys Ala Ala Arg His Leu Asp Ser Val
                 965                 970                 975    
 Leu Ser Asp His Thr Arg Asn Ser Ala Glu Gly Thr Glu Tyr Phe Lys
             980                 985                 990        
 Met Leu Val Asp Val Phe Ala Pro Glu Phe Arg Arg Pro Lys Asn Ile
         995                1000                1005            
 His Leu Arg Asn Phe Tyr Ile Ile Val Pro Pro Leu Thr Leu Asn Phe
    1010                1015                1020                
 Val Glu His Ser Ile Ser Cys Lys Glu Lys Leu Asn Lys Lys Asn Lys
1025                1030                1035                1040
 Ile Gly Ala Ala Phe Thr Asp Asp Gly Phe Ala Met Gly Val Ala Tyr
                1045                1050                1055    
 Ile Leu Lys Leu Leu Asp Gln Tyr Arg Glu Phe Asp Ser Leu His Trp
            1060                1065                1070        
 Phe Gln Ser Val Arg Glu Lys Tyr Leu Lys Glu Ile Arg Ala Val Ala
        1075                1080                1085            
 Lys Gln Gln Asn Val Gln Ser Ala Ser Gln Asp Glu Lys Leu Leu Gln
    1090                1095                1100                
 Thr Met Asn Leu Thr Gln Lys Arg Leu Asp Val Tyr Leu Gln Glu Phe
1105                1110                1115                1120
 Glu Leu Leu Tyr Phe Ser Leu Ser Ser Ala Arg Ile Phe Phe Arg Ala
                1125                1130                1135    
 Asp Lys Thr Ala Ala Glu Glu Asn Gln Glu Lys Lys Glu Lys Glu Glu
            1140                1145                1150        
 Glu Thr Lys Thr Ser Asn Gly Asp Leu Ser Asp Ser Thr Val Ser Ala
        1155                1160                1165            
 Asp Pro Val Val Lys
    1170            



      <210> 862
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 862
 Met Phe Gln Arg Leu Asn Lys Met Phe Val Gly Glu Val Ser Ser Ser
   1               5                  10                  15    
 Ser Asn Gln Glu Pro Glu Phe Asn Glu Lys Glu Asp Asp Glu Trp Ile
              20                  25                  30        
 Leu Val Asp Phe Ile Asp Thr Cys Thr Gly Phe Ser Ala Glu Glu Glu
          35                  40                  45            
 Glu Glu Glu Glu Asp Ile Ser Glu Glu Ser Pro Thr Glu His Pro Ser
      50                  55                  60                
 Val Phe Ser Cys Leu Pro Ala Ser Leu Glu Cys Leu Ala Asp Thr Ser
  65                  70                  75                  80
 Asp Ser Cys Phe Leu Gln Phe Glu Ser Cys Pro Met Glu Glu Ser Trp
                  85                  90                  95    
 Phe Ile Thr Pro Pro Pro Cys Phe Thr Ala Gly Gly Leu Thr Thr Ile
             100                 105                 110        
 Lys Val Glu Thr Ser Pro Met Glu Asn Leu Leu Ile Glu His Pro Ser
         115                 120                 125            
 Met Ser Val Tyr Ala Val His Asn Ser Cys Pro Gly Leu Ser Glu Ala
     130                 135                 140                
 Thr Arg Gly Thr Asp Glu Leu His Ser Pro Ser Ser Pro Arg Ala Arg
 145                 150                 155                 160
 Lys Ser Cys Leu
                



      <210> 863
      <211> 741
      <212> PRT
      <213> Homo sapiens


      <400> 863
 Met Asp Thr Thr Thr Asp Lys Trp Val Lys Leu Thr Asp Asn Gly Glu
   1               5                  10                  15    
 Trp Gly Ser His Ser Val Met Leu Lys Ser Gly Thr Asn Ile Leu Tyr
              20                  25                  30        
 Trp Arg Thr Thr Gly Ile Leu Met Gly Ser Lys Ala Val Lys Pro Val
          35                  40                  45            
 Leu Val Lys Asn Ile Thr Ile Glu Gly Val Ala Tyr Thr Ser Glu Cys
      50                  55                  60                
 Phe Pro Cys Lys Pro Gly Thr Phe Ser Asn Lys Pro Gly Ser Phe Asn
  65                  70                  75                  80
 Cys Gln Ser Cys Lys Ile Ile Asp Pro Phe Leu Lys Arg Phe Phe Tyr
                  85                  90                  95    
 Val Ala Glu Glu Gly Ser Ser Glu Cys Thr Glu Arg Pro Pro Cys Thr
             100                 105                 110        
 Thr Lys Asp Tyr Phe Gln Ile His Thr Pro Cys Asp Glu Glu Gly Lys
         115                 120                 125            
 Thr Gln Ile Met Tyr Lys Trp Ile Glu Pro Lys Ile Cys Arg Glu Asp
     130                 135                 140                
 Leu Thr Asp Ala Ile Arg Leu Pro Pro Ser Gly Glu Lys Lys Asp Cys
 145                 150                 155                 160
 Pro Pro Cys Asn Pro Gly Phe Tyr Asn Asn Gly Ser Ser Ser Cys His
                 165                 170                 175    
 Pro Cys Pro Pro Gly Thr Phe Ser Asp Gly Thr Lys Glu Cys Arg Pro
             180                 185                 190        
 Cys Pro Ala Gly Thr Glu Pro Ala Leu Gly Phe Glu Tyr Lys Trp Trp
         195                 200                 205            
 Asn Val Leu Pro Gly Asn Met Lys Thr Ser Cys Phe Asn Val Gly Asn
     210                 215                 220                
 Ser Lys Cys Asp Gly Met Asn Gly Trp Glu Val Ala Gly Asp His Ile
 225                 230                 235                 240
 Gln Ser Gly Ala Gly Gly Ser Asp Asn Asp Tyr Leu Ile Leu Asn Leu
                 245                 250                 255    
 His Ile Pro Gly Phe Lys Pro Pro Thr Ser Met Thr Gly Ala Thr Gly
             260                 265                 270        
 Ser Glu Leu Gly Arg Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Ala
         275                 280                 285            
 Asp Cys Val Leu Tyr Phe Met Val Asp Ile Asn Arg Lys Ser Thr Asn
     290                 295                 300                
 Val Val Glu Ser Trp Gly Gly Thr Lys Glu Lys Gln Ala Tyr Thr His
 305                 310                 315                 320
 Ile Ile Phe Lys Asn Ala Thr Phe Thr Phe Thr Trp Ala Phe Gln Arg
                 325                 330                 335    
 Thr Asn Gln Gly Gln Asp Asn Arg Arg Phe Ile Asn Asp Met Val Lys
             340                 345                 350        
 Ile Tyr Ser Ile Thr Ala Thr Asn Ala Val Asp Gly Val Ala Ser Ser
         355                 360                 365            
 Cys Arg Ala Cys Ala Leu Gly Ser Glu Gln Ser Gly Ser Ser Cys Val
     370                 375                 380                
 Pro Cys Pro Pro Gly His Tyr Ile Glu Lys Glu Thr Asn Gln Cys Lys
 385                 390                 395                 400
 Glu Cys Pro Pro Asp Thr Tyr Leu Ser Ile His Gln Val Tyr Gly Lys
                 405                 410                 415    
 Glu Ala Cys Ile Pro Cys Gly Pro Gly Ser Lys Asn Asn Gln Gly Lys
             420                 425                 430        
 Lys Met Ala Leu Cys Thr Asn Asn Ile Thr Asp Phe Thr Val Lys Glu
         435                 440                 445            
 Ile Val Ala Gly Ser Asp Asp Tyr Thr Asn Leu Val Gly Ala Phe Val
     450                 455                 460                
 Cys Gln Ser Thr Ile Ile Pro Ser Glu Ser Lys Gly Phe Arg Ala Ala
 465                 470                 475                 480
 Leu Ser Ser Gln Ser Ile Ile Leu Ala Asp Thr Phe Ile Gly Val Thr
                 485                 490                 495    
 Val Glu Thr Thr Leu Lys Asn Ile Asn Ile Lys Glu Asp Met Phe Pro
             500                 505                 510        
 Val Pro Thr Ser Gln Ile Pro Asp Val His Phe Phe Tyr Lys Ser Ser
         515                 520                 525            
 Thr Ala Thr Thr Ser Cys Ile Asn Gly Arg Ser Thr Ala Val Lys Met
     530                 535                 540                
 Arg Cys Asn Pro Thr Lys Ser Gly Ala Gly Val Ile Ser Val Pro Ile
 545                 550                 555                 560
 Lys Cys Pro Ala Gly Thr Cys Asp Gly Cys Thr Phe Tyr Phe Leu Trp
                 565                 570                 575    
 Glu Ser Ala Glu Ala Cys Pro Leu Cys Thr Glu His Asp Phe His Glu
             580                 585                 590        
 Ile Glu Gly Ala Cys Lys Arg Gly Phe Gln Glu Thr Leu Tyr Val Trp
         595                 600                 605            
 Asn Glu Pro Lys Trp Cys Ile Lys Gly Ile Ser Leu Pro Glu Lys Lys
     610                 615                 620                
 Leu Ala Thr Cys Glu Thr Val Asp Phe Trp Leu Lys Val Gly Ala Gly
 625                 630                 635                 640
 Val Gly Ala Phe Thr Ala Val Leu Leu Val Ala Leu Thr Cys Tyr Phe
                 645                 650                 655    
 Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu Val Met
             660                 665                 670        
 Thr Thr Asn Ser Lys Glu Cys Glu Leu Pro Ala Ala Asp Ser Cys Ala
         675                 680                 685            
 Ile Met Glu Gly Glu Asp Asn Glu Glu Glu Val Val Tyr Phe Asn Lys
     690                 695                 700                
 Gln Ser Leu Leu Gly Lys Leu Lys Ser Leu Ala Thr Lys Glu Lys Glu
 705                 710                 715                 720
 Asp His Phe Glu Ser Val Gln Leu Lys Thr Ser Lys Ser Gln Ile Tyr
                 725                 730                 735    
 Glu Glu Thr Val Leu
             740    



      <210> 864
      <211> 609
      <212> PRT
      <213> Homo sapiens


      <400> 864
 Met Val Tyr Gly Ala Ser Lys Ala Ile Arg Gln Pro Gln Ser Ser Ala
   1               5                  10                  15    
 Ala Lys Pro Arg Arg Ser Gln Ser Gly Ser Leu Gly Pro Glu Phe Gln
              20                  25                  30        
 Gly Leu Trp Glu Trp Leu Pro Val Gln Leu Tyr Leu Ile Leu Lys Asp
          35                  40                  45            
 Asn Leu His Gly Gly Ala Pro Ile Pro Pro Lys Val Ser His Thr Gln
      50                  55                  60                
 Ser Leu Gly Asp Thr Cys Trp Pro Trp Gln Ala Leu His Val Arg Cys
  65                  70                  75                  80
 Asp Gln Asp Thr Gly Gly His Ser Val Thr Cys Pro Trp Leu Cys Asp
                  85                  90                  95    
 Gln Gly Thr Asp Met Arg Lys Gly Tyr Phe Ala Ala Ile Gln Gly Asp
             100                 105                 110        
 Gln Gly Lys Ser Ser Pro Asp Gly Ile Leu Ala Ala His Leu Glu Pro
         115                 120                 125            
 Tyr Thr Val Arg Val Glu Asp Gln Arg Ser Met Arg Gly Asn Val Ala
     130                 135                 140                
 Val Phe Lys Cys Leu Ile Pro Ser Ser Val Gln Glu Tyr Val Ser Val
 145                 150                 155                 160
 Val Ser Trp Glu Lys Asp Thr Val Ser Ile Ile Pro Gly Arg Gln Val
                 165                 170                 175    
 Pro Glu Gln Leu Ile Glu Lys Thr Asn Glu Thr Arg Leu Tyr Leu Tyr
             180                 185                 190        
 Leu Ser Leu Glu Arg Leu Val Val Thr Glu Glu Gly Asp Arg Gln Ala
         195                 200                 205            
 Glu His Ser Glu Ser Ala Leu Asp Arg Ser Gln Ser Ala Val Leu Thr
     210                 215                 220                
 Ala Met Ser Leu Asp Ala Ser Pro Asn Leu Val Arg Gln Arg Thr Leu
 225                 230                 235                 240
 Glu Gly Pro Ser Arg Arg Gly Glu Ala Gly Ser Arg Gly Val Ala Lys
                 245                 250                 255    
 Thr Ile Ala Ser Arg Leu Leu Leu Gln Ala Ala Ser Asp Thr Leu Asn
             260                 265                 270        
 Trp Gly Pro Asn Thr Glu Cys Pro Arg Gly Ile Arg Ala Val Trp Gly
         275                 280                 285            
 Ala Ser Asp His Ser Gly Arg Ala Phe Gly Lys Thr Gln Ala Tyr Gly
     290                 295                 300                
 Arg Ala Gln Ala Gln Pro Val Asn Pro Val Ile Met Ala Ile Lys Asn
 305                 310                 315                 320
 Tyr Leu Val Thr Ala Arg Pro Val Ser Thr Leu Gly Trp Pro Cys Gln
                 325                 330                 335    
 Gly Gly Tyr Arg Asn Leu Thr Glu Thr Leu Trp Ser Gln Val Ser His
             340                 345                 350        
 Thr Glu Thr Ala His Cys Gly Phe Ala Val Gly Lys Ala Leu Val Ala
         355                 360                 365            
 Glu Glu Gln Arg Leu Pro Gly Gln Cys Ser Gly Leu Pro Cys Met Glu
     370                 375                 380                
 Gly Ile Leu Val Ile Ile Pro Ala Gln Leu Phe His Leu Asn Gly Glu
 385                 390                 395                 400
 Glu Thr Glu Val Gln Lys Gly Lys Val Thr Cys His Ser Trp Thr Ala
                 405                 410                 415    
 Arg Lys Leu Ser Arg Ile Ser Leu Ala Ser His Pro Leu Ser Pro Pro
             420                 425                 430        
 Pro His Phe Thr Glu Asp Lys Thr Ser Pro Phe Leu Arg Glu Val Gln
         435                 440                 445            
 Val Asn Leu Ile Asp Phe Lys Lys Cys Asn Asp Tyr Leu Val Tyr Asp
     450                 455                 460                
 Ser Tyr Leu Thr Pro Arg Met Met Cys Ala Gly Asp Leu Arg Gly Gly
 465                 470                 475                 480
 Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Gln
                 485                 490                 495    
 Asn Asn Arg Trp Tyr Leu Ala Gly Val Thr Ser Trp Gly Thr Gly Cys
             500                 505                 510        
 Gly Gln Arg Asn Lys Pro Gly Val Tyr Thr Lys Val Thr Glu Val Leu
         515                 520                 525            
 Pro Trp Ile Tyr Ser Lys Met Glu Thr Ser Pro Val Trp Ala Asp Ala
     530                 535                 540                
 Ser Gly Pro Gly Gly Ala Ile Ala Val Leu Gly Trp Ile Val Gly Phe
 545                 550                 555                 560
 Gly Gly Cys Ser Phe Pro Gly Pro Gly Pro Ser Ser Val Lys Ser Cys
                 565                 570                 575    
 Ser Arg Trp Leu Tyr Glu His Gln Val Leu Thr Gln Thr Pro Cys Trp
             580                 585                 590        
 Cys Arg Gly Cys His Gln Ser Asp Cys Ala Val Ala Asn Gln Ala Asp
         595                 600                 605            
 Asn
    



      <210> 865
      <211> 491
      <212> PRT
      <213> Homo sapiens


      <400> 865
 Met Asp Gly Asn Asp Asn Val Thr Leu Leu Phe Ala Pro Leu Leu Arg
   1               5                  10                  15    
 Asp Asn Tyr Thr Leu Ala Pro Asn Ala Ser Ser Leu Gly Pro Gly Thr
              20                  25                  30        
 Asn Leu Ala Leu Ala Pro Ala Ser Ser Ala Gly Pro Gly Pro Gly Leu
          35                  40                  45            
 Ser Leu Gly Pro Val Pro Ser Phe Gly Phe Ser Pro Gly Pro Thr Pro
      50                  55                  60                
 Thr Pro Glu Pro Thr Thr Ser Gly Leu Ala Gly Gly Ala Ala Ser His
  65                  70                  75                  80
 Gly Pro Ser Pro Phe Pro Arg Pro Trp Ala Pro His Ala Leu Pro Phe
                  85                  90                  95    
 Trp Asp Thr Pro Leu Asn His Gly Leu Asn Val Phe Val Gly Ala Ala
             100                 105                 110        
 Leu Cys Ile Thr Met Leu Gly Leu Gly Cys Thr Val Asp Val Asn His
         115                 120                 125            
 Phe Gly Ala His Val Arg Arg Pro Val Ala Ala Leu Leu Ala Ala Leu
     130                 135                 140                
 Pro Val Arg Pro Pro Ala Ala Ala Gly Leu Pro Ala Gly Pro Arg Leu
 145                 150                 155                 160
 Gln Ala Gly Arg Gly Gly Arg Arg Gly Leu Leu Leu Cys Gly Cys Cys
                 165                 170                 175    
 Pro Gly Gly Asn Leu Ser Asn Leu Met Ser Leu Leu Val Asp Gly Asp
             180                 185                 190        
 Met Asn Leu Arg Arg Ala Ala Leu Leu Ala Leu Ser Ser Asp Val Gly
         195                 200                 205            
 Ser Ala Gln Thr Ser Thr Pro Gly Leu Ala Val Ser Pro Phe His Leu
     210                 215                 220                
 Tyr Ser Thr Tyr Lys Lys Lys Val Ser Trp Leu Phe Asp Ser Lys Leu
 225                 230                 235                 240
 Val Leu Ile Ser Ala His Ser Leu Phe Cys Ser Ile Ile Met Thr Ile
                 245                 250                 255    
 Ser Ser Thr Leu Leu Ala Leu Val Leu Met Pro Leu Cys Leu Trp Ile
             260                 265                 270        
 Tyr Ser Trp Ala Trp Ile Asn Thr Pro Ile Val Gln Leu Leu Pro Leu
         275                 280                 285            
 Gly Thr Val Thr Leu Thr Leu Cys Ser Thr Leu Ile Pro Ile Gly Leu
     290                 295                 300                
 Gly Val Phe Ile Arg Tyr Lys Tyr Ser Arg Val Ala Asp Tyr Ile Val
 305                 310                 315                 320
 Lys Val Ser Leu Trp Ser Leu Leu Val Thr Leu Val Val Leu Phe Ile
                 325                 330                 335    
 Met Thr Gly Thr Met Leu Gly Pro Glu Leu Leu Ala Ser Ile Pro Ala
             340                 345                 350        
 Ala Val Tyr Val Ile Ala Ile Phe Met Pro Leu Ala Ala Tyr Ala Ser
         355                 360                 365            
 Gly Tyr Gly Leu Ala Thr Leu Phe His Leu Pro Pro Asn Cys Lys Arg
     370                 375                 380                
 Thr Val Cys Leu Glu Thr Gly Ser Gln Asn Val Gln Leu Cys Thr Ala
 385                 390                 395                 400
 Ile Leu Lys Leu Ala Phe Pro Pro Gln Phe Ile Gly Ser Met Tyr Met
                 405                 410                 415    
 Phe Pro Leu Leu Tyr Ala Leu Phe Gln Ser Ala Glu Ala Gly Ile Phe
             420                 425                 430        
 Val Leu Ile Tyr Lys Met Tyr Gly Ser Glu Met Leu His Lys Arg Asp
         435                 440                 445            
 Pro Leu Asp Glu Asp Glu Asp Thr Asp Ile Ser Tyr Lys Lys Leu Lys
     450                 455                 460                
 Glu Glu Glu Met Ala Asp Thr Ser Tyr Gly Thr Val Lys Ala Glu Asn
 465                 470                 475                 480
 Ile Ile Met Met Glu Thr Ala Gln Thr Ser Leu
                 485                 490    



      <210> 866
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 866
 Met Ile Leu Gln Gln Pro Leu Gln Arg Gly Pro Gln Gly Gly Ala Gln
   1               5                  10                  15    
 Arg Leu Pro Arg Ala Ala Leu Gly Val Thr Trp Gly Leu Asp Ala Ser
              20                  25                  30        
 Ser Pro Leu Arg Gly Ala Val Pro Met Ser Thr Lys Arg Arg Leu Glu
          35                  40                  45            
 Glu Glu Gln Glu Pro Leu Arg Lys Gln Phe Leu Ser Glu Glu Asn Met
      50                  55                  60                
 Ala Thr His Phe Ser Gln Leu Ser Leu His Asn Asp His Pro Tyr Cys
  65                  70                  75                  80
 Ser Pro Pro Met Thr Phe Ser Pro Ala Leu Pro Pro Leu Arg Ser Pro
                  85                  90                  95    
 Cys Ser Glu Leu Leu Leu Trp Arg Tyr Pro Gly Ser Leu Ile Pro Glu
             100                 105                 110        
 Ala Leu Arg Leu Leu Arg Leu Gly Asp Thr Pro Val Pro Pro Thr Leu
         115                 120                 125            
 Gln Pro Gln Leu Gly Thr
     130                



      <210> 867
      <211> 322
      <212> PRT
      <213> Homo sapiens


      <400> 867
 Met Ala Ser Ser Leu Lys Ile Trp Gly Ser Pro Leu Ala Leu Leu Cys
   1               5                  10                  15    
 Ile Leu Cys Arg Leu Leu Val His Ser Lys Asp Val Ser Trp Arg Glu
              20                  25                  30        
 Phe Met Thr Leu His Tyr Leu Asp Pro Ser Gln Asp Phe Glu Glu Tyr
          35                  40                  45            
 Lys Cys Asp Val Leu Thr Arg Glu Lys Glu Ala Leu Lys Arg Lys Ser
      50                  55                  60                
 Ser His Met Ser Ile Tyr Ser Leu Trp His Lys Met Glu Cys Ile Cys
  65                  70                  75                  80
 Ile Ile Glu Met Gly Ile Thr Asp Ile Asp Met Pro Met Tyr Gly Pro
                  85                  90                  95    
 Arg Val Pro Ser Lys Tyr Ser Ser Val Ser Gly Arg Ser Thr Ala Ile
             100                 105                 110        
 Ala Thr Gln Arg Ser Ser Thr Thr Leu Asn Ser Thr Val Ala Arg Met
         115                 120                 125            
 Gly Trp Val Asn Ile Thr Val Ser Pro Asp Gln Ala Arg Thr Leu Gln
     130                 135                 140                
 Ala Ala Leu Leu Gln Gln Leu Ala Gln Asn Phe Ser Leu Ile Pro Glu
 145                 150                 155                 160
 Glu Phe Leu Gln Glu Val Asp Thr Gln Val Asp Val Val Thr Glu Met
                 165                 170                 175    
 Thr Ser Ser Leu Lys Ile Trp Gly Ile Leu Leu Ala Leu Leu Cys Ile
             180                 185                 190        
 Leu Cys Arg Leu Cys Val Tyr Ser Asn Asn Ile Tyr Trp Arg Glu Phe
         195                 200                 205            
 Ile Lys Leu His Tyr Leu Ser Pro Ser Arg Glu Phe Lys Glu Tyr Lys
     210                 215                 220                
 Cys Asp Val Leu Met Arg Glu Lys Glu Ala Leu Lys Gly Lys Ser Phe
 225                 230                 235                 240
 His Met Phe Ile Tyr Ser Leu Trp Phe Lys Ile Gln Arg Ala Cys Ile
                 245                 250                 255    
 Asn Glu Lys Gly Ser Asp Arg Tyr Arg Asn Ala Tyr Val Trp Ala Pro
             260                 265                 270        
 Gly Ala Leu Lys Val Leu Glu Cys His Trp Glu Lys Tyr Asn Asn Arg
         275                 280                 285            
 Tyr Thr Glu Ser Arg Ser Phe Ser Tyr Ile Glu Phe His Cys Gly Val
     290                 295                 300                
 Asp Gly Tyr Val Asp Asn Ile Glu Asp Leu Arg Ile Ile Glu Pro Ile
 305                 310                 315                 320
 Ser Asn
        



      <210> 868
      <211> 479
      <212> PRT
      <213> Homo sapiens


      <400> 868
 Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala Cys Glu Lys Arg Glu
   1               5                  10                  15    
 Gln Leu Glu His Arg Leu Arg Thr Arg Leu Glu Arg Glu Leu Glu Ser
              20                  25                  30        
 Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln Pro Thr Asn Val Ser
          35                  40                  45            
 Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu Arg Glu Lys Glu Glu
      50                  55                  60                
 Arg Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr
  65                  70                  75                  80
 Leu Glu Glu Asn Val Met Arg His Phe Ala Leu Asp Ala Ala Ala Thr
                  85                  90                  95    
 Val Ala Ala Gln Arg Asp Thr Thr Val Ile Ser His Ser Pro Asn Thr
             100                 105                 110        
 Ser Tyr Asp Thr Ala Leu Glu Ala Arg Ile Gln Lys Glu Glu Glu Glu
         115                 120                 125            
 Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met Glu Gly Arg Ile Lys
     130                 135                 140                
 Thr Leu His Ala Gln Ile Ile Glu Lys Asp Ala Met Ile Lys Val Leu
 145                 150                 155                 160
 Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Thr Glu Gln Leu Ser Cys
                 165                 170                 175    
 Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser Asn Ala Gly Ser Gly
             180                 185                 190        
 Leu Leu Ser His Ser Ser Thr Leu Thr Gly Ser Pro Ile Met Glu Glu
         195                 200                 205            
 Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu Gly Ile Leu Leu Gly
     210                 215                 220                
 Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser Thr Pro Ser Pro Val Pro
 225                 230                 235                 240
 Pro Ser Thr Pro Leu Leu Ser Ala His Ser Lys Thr Gly Ser Arg Asp
                 245                 250                 255    
 Cys Ser Thr Gln Thr Glu Arg Gly Thr Glu Ser Asn Lys Thr Ala Ala
             260                 265                 270        
 Val Ala Pro Ile Ser Val Pro Ala Pro Val Ala Ala Ala Ala Thr Ala
         275                 280                 285            
 Ala Ala Ile Thr Ala Thr Ala Ala Thr Ile Thr Thr Thr Met Val Ala
     290                 295                 300                
 Ala Ala Pro Val Ala Val Ala Ala Ala Ala Ala Pro Ala Ala Ala Ala
 305                 310                 315                 320
 Ala Pro Ser Pro Ala Thr Ala Ala Ala Thr Ala Ala Ala Val Ser Pro
                 325                 330                 335    
 Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser Val Ala Ser Ala Ala
             340                 345                 350        
 Ala Val Ala Pro Ser Ala Ala Ala Ala Ala Ala Val Gln Val Ala Pro
         355                 360                 365            
 Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu Val Pro Val Pro Ala
     370                 375                 380                
 Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln Thr Gln Ala Pro Thr
 385                 390                 395                 400
 Ser Ala Pro Ala Val Ala Pro Thr Pro Ala Pro Thr Pro Thr Pro Ala
                 405                 410                 415    
 Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala Thr Gly Pro Gly Pro
             420                 425                 430        
 His Arg Leu Ser Ile Pro Ser Leu Thr Cys Asn Pro Asp Lys Thr Asp
         435                 440                 445            
 Gly Pro Val Phe His Ser Asn Thr Leu Glu Arg Lys Thr Pro Ile Gln
     450                 455                 460                
 Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val Glu Tyr Leu Ile
 465                 470                 475                



      <210> 869
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 869
 Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala
   1               5                  10                  15    
 Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu
              20                  25                  30        
 Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr
          35                  40                  45            
 Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp
      50                  55                  60                
 Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala
  65                  70                  75                  80
 Glu Asn Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln
                  85                  90                  95    
 Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp
             100                 105                 110        
 Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu
         115                 120                 125            
 Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Gly Leu Phe Cys Pro
     130                 135                 140                
 Cys Asn Lys Val Thr Lys Asn Trp Thr Asn Leu His Gly
 145                 150                 155        



      <210> 870
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 870
 Met Arg Ile Leu Ile Phe Glu Ile Thr Ala Ile Tyr Pro Leu His Ile
   1               5                  10                  15    
 Pro Leu Tyr Tyr Ala Asn Gln Arg Phe Gly Lys Phe Arg His Arg Arg
              20                  25                  30        
 Glu Leu Asp Ser Phe Pro Pro Gly Glu Met Lys Ser Phe Leu Ala Leu
          35                  40                  45            
 Lys Ser Leu Ile Lys Gly Val His Asn Ser Cys Val Tyr Cys Thr Glu
      50                  55                  60                
 Tyr Cys Arg
  65        



      <210> 871
      <211> 462
      <212> PRT
      <213> Homo sapiens


      <400> 871
 Met Leu Leu Asn Ile Thr Arg Cys Gln Thr Thr Pro Thr Thr Arg Asn
   1               5                  10                  15    
 Tyr Val Gly Gln Asn Val Ile Asn Thr Arg Ile Glu Lys Pro Thr Leu
              20                  25                  30        
 Glu Lys Lys Val Arg Lys Lys Ser Ser Ser Glu Arg Ser Val Leu Cys
          35                  40                  45            
 Glu Val Cys Lys Ile Asn Gln Ala Gln Arg Asp Met Ser Met Lys Leu
      50                  55                  60                
 Gln His Thr Pro Ala Gly Lys Ser Leu Ala Arg Thr Glu Val Leu Glu
  65                  70                  75                  80
 Gly Ala Asp Ser Ser Tyr Asp Glu Trp Leu Leu Leu Gln Arg Ala Thr
                  85                  90                  95    
 His Phe Phe Val Ser Leu Asp Lys Lys Gly Tyr Cys Glu Asp Tyr Asn
             100                 105                 110        
 Gly Lys Leu Val Cys Thr Arg Leu Lys Gly Glu Val Glu Arg Ile Arg
         115                 120                 125            
 Leu Ser Thr His Leu Glu Glu Gly Cys Val Arg Ser Tyr Val Pro Glu
     130                 135                 140                
 Asn Gly Lys Lys Leu Arg Pro Gly Asn Thr Gly Ser Gln Glu Asn Ser
 145                 150                 155                 160
 Arg Arg Arg Gly Thr Met Asn Glu Glu Glu Gln Phe Val Asn Ile Asp
                 165                 170                 175    
 Leu Asn Asp Asp Asn Ile Cys Ser Val Cys Lys Leu Gly Thr Asp Lys
             180                 185                 190        
 Glu Thr Leu Ser Phe Cys His Ile Cys Phe Glu Leu Asn Ile Glu Gly
         195                 200                 205            
 Val Pro Lys Ser Asp Leu Leu His Thr Lys Ser Leu Arg Gly His Lys
     210                 215                 220                
 Asp Cys Phe Glu Lys Tyr His Leu Ile Ala Asn Gln Gly Cys Pro Arg
 225                 230                 235                 240
 Ser Lys Leu Ser Lys Ser Thr Tyr Glu Glu Val Lys Thr Ile Leu Ser
                 245                 250                 255    
 Lys Lys Ile Asn Trp Ile Val Gln Tyr Ala Gln Asn Lys Asp Leu Asp
             260                 265                 270        
 Ser Asp Ser Glu Cys Ser Lys Asn Pro Gln His His Leu Phe Asn Phe
         275                 280                 285            
 Arg His Lys Pro Glu Glu Lys Leu Leu Pro Gln Phe Asp Ser Gln Val
     290                 295                 300                
 Pro Lys Tyr Ser Ala Lys Trp Ile Asp Gly Ser Ala Gly Gly Ile Ser
 305                 310                 315                 320
 Asn Cys Thr Gln Arg Ile Leu Glu Gln Arg Glu Asn Thr Asp Phe Gly
                 325                 330                 335    
 Leu Ser Met Leu Gln Asp Ser Gly Ala Thr Leu Cys Arg Asn Ser Val
             340                 345                 350        
 Leu Trp Pro His Ser His Asn Gln Ala Gln Lys Lys Glu Glu Thr Ile
         355                 360                 365            
 Ser Ser Pro Glu Ala Asn Val Gln Thr Gln His Pro His Tyr Ser Arg
     370                 375                 380                
 Glu Glu Leu Asn Ser Met Thr Leu Gly Glu Val Glu Gln Leu Asn Ala
 385                 390                 395                 400
 Lys Leu Leu Gln Gln Ile Gln Glu Val Phe Glu Glu Leu Thr His Gln
                 405                 410                 415    
 Val Gln Glu Lys Asp Ser Leu Ala Ser Gln Leu His Val Arg His Val
             420                 425                 430        
 Ala Ile Glu Gln Leu Leu Lys Asn Cys Ser Lys Leu Pro Cys Leu Gln
         435                 440                 445            
 Val Gly Arg Thr Gly Met Lys Ser His Leu Pro Ile Asn Asn
     450                 455                 460        



      <210> 872
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 872
 Met Arg Thr Arg Ala Leu Pro Ile Pro Val Gly Ser Pro Pro Ile Gly
   1               5                  10                  15    
 Trp Val Trp Ala His Val Thr Asp Met Trp Leu Tyr Trp Cys Ser Pro
              20                  25                  30        
 Pro Gly Cys His Trp Arg Gln Asn Gly Gly Ala Ala Gly Leu Gly Asn
          35                  40                  45            
 Gly Ser Gly Ile Thr Val Ser Lys Glu Thr Gly Arg Gly Gln Gln Arg
      50                  55                  60                
 Met Glu His Ile His Gly Glu Glu Gln Lys Leu Tyr Pro Ile Glu Arg
  65                  70                  75                  80
 Leu Leu Phe Leu Pro Gly Asp Lys Asp Thr Cys Ile Gly Gly Gln Lys
                  85                  90                  95    
 Arg Glu Glu Thr Lys Pro Leu Gln Met Ala Asp Val Asn Leu Val Glu
             100                 105                 110        
 Arg Ala Thr Gly Asp Glu Arg Lys Arg Arg Arg Gln Arg Arg Ile Ala
         115                 120                 125            
 Arg Ile Gln Gln Ile Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu
     130                 135                 140                
 Gln Ser Gln Ala Thr Glu Ala Glu Phe Phe Asp Thr Thr Val Tyr Pro
 145                 150                 155                 160
 Pro Val Gly Phe Asn Phe Asp Pro Asn Tyr Pro Glu Leu Glu Ser Ala
                 165                 170                 175    
 Pro Gln Val Lys Asp Lys Val Ser His Lys Thr Val His Phe Lys Arg
             180                 185                 190        
 Gln Pro Gln Val Leu Gly Val Pro Lys Pro Pro Gly Leu Leu Pro Ser
         195                 200                 205            
 Cys Leu
     210



      <210> 873
      <211> 874
      <212> PRT
      <213> Homo sapiens


      <400> 873
 Met Glu Ala Glu Leu Lys Ala Leu Pro Ser Asp Ser Pro Arg Asn Val
   1               5                  10                  15    
 Leu Thr Gly Ala Phe Arg Gly Ala Gln Pro Val Leu Leu Leu Leu Lys
              20                  25                  30        
 Glu His Pro Arg Glu Cys Val Lys Pro Arg Tyr Arg Thr Ser Arg Gln
          35                  40                  45            
 Glu Thr Lys Thr Gly Arg Cys Gln Asp Glu His Pro Phe Cys Ser Ala
      50                  55                  60                
 Val Ala Arg Gly Pro Val Phe Pro Gln Thr Pro Ala Ala Asp Pro Arg
  65                  70                  75                  80
 Thr Glu Gln Asp Pro Gly His Gly Glu Glu Glu Arg Thr Arg Thr Leu
                  85                  90                  95    
 Gln Ile Ser Gly Arg Ser Ala Val Met Glu Leu Ala Val Asp Leu Thr
             100                 105                 110        
 Ser Ala Glu Cys Ile Cys Ser Pro Gly Arg Leu Asp Ala Gln Gly Leu
         115                 120                 125            
 Gln Ala Ser Ala Ser Ala Ala Asp Asn His Arg Gly Leu Pro Gly Gly
     130                 135                 140                
 Leu Arg Thr Leu Leu Ile His Gln Leu Gln Gly Leu Gln His Trp Asn
 145                 150                 155                 160
 Thr Thr Trp His Thr Ala Leu Leu Lys Gly Cys Glu Arg Leu Ser Ala
                 165                 170                 175    
 Val Pro Asp Thr Ala Pro Pro Gly Glu Gly Leu His Ser Lys Ala Leu
             180                 185                 190        
 Leu Leu Pro Leu Leu Ala Val Pro Ala Ala Leu Thr His Gln Gln Lys
         195                 200                 205            
 Met Glu Met Glu Leu Val Lys Gln Glu Asp Arg Lys Ser Met Thr Gly
     210                 215                 220                
 Glu Asn Phe Ser Gln Arg Thr Gly Pro His Arg Trp Gln Ala Pro Ser
 225                 230                 235                 240
 Gln Cys Gly Lys Gln His Pro Ala Asn Pro Ser His Thr His Thr Thr
                 245                 250                 255    
 Asn Thr Tyr Gln Pro Leu Ser Ser His Pro Ala Thr His Thr Ile His
             260                 265                 270        
 Ala Trp Val Thr Thr Ser Pro Pro Ile Pro Gly Asn Pro Pro Ser Thr
         275                 280                 285            
 Ser Ser Gln Ser Leu Ile Ala Ala Ala Phe Trp Gly His Phe His Gln
     290                 295                 300                
 Gln Ala Gly His Ala Leu Lys Tyr Thr His Thr Leu His Glu Phe Pro
 305                 310                 315                 320
 Asn Arg Gly His Thr Leu Gln Tyr Thr His Thr Leu His Val Phe Pro
                 325                 330                 335    
 Asp Gly Gly Leu Ala Leu Gln Tyr Ala His Ile Leu His Val Phe Pro
             340                 345                 350        
 Asp Gly Gly His Thr Leu Trp Tyr Thr His Ala Leu His Val Phe Pro
         355                 360                 365            
 Asp Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val Phe Pro
     370                 375                 380                
 Asp Gly Gly Pro Ala Leu Gln Tyr Ala His Thr Leu His Val Phe Pro
 385                 390                 395                 400
 Asp Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val Phe Pro
                 405                 410                 415    
 Asp Gly Gly Pro Ala Leu Gln Tyr Ala His Thr Leu His Val Phe Pro
             420                 425                 430        
 Asp Gly Gly His Met Leu Trp Tyr Thr His Thr Leu His Met Phe Ser
         435                 440                 445            
 Asp Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val Phe Pro
     450                 455                 460                
 Asp Gly Gly Pro Ala Leu Pro Tyr Thr His Thr Leu His Val Phe Pro
 465                 470                 475                 480
 Val Gly Gly His Thr Leu Trp Tyr Thr His Thr Leu His Val Phe Ser
                 485                 490                 495    
 Asp Gly Gly His Ser Ala Ala Val His Thr His Thr Ser Arg Val Leu
             500                 505                 510        
 Arg Arg Arg Pro Trp His His Cys Arg Ser His Ala Ser Ala Val Thr
         515                 520                 525            
 Ala Gln Cys Arg Leu Pro Gly Gly Gly Ala His Ser Val Pro Phe Leu
     530                 535                 540                
 Val Ser Ala Gly Cys Gly Ser Val Asp Ala Asn Val Leu Asn Asp Thr
 545                 550                 555                 560
 Gly Arg Thr Glu Glu Met Pro Gly Thr Val Ala Pro Thr Ala Leu Val
                 565                 570                 575    
 Ser His Val Pro Arg Ser Thr Phe Thr Leu Gln His Thr Arg Thr Cys
             580                 585                 590        
 Tyr Gln Ala Asp Gly His Thr Asp His Leu Cys Trp Phe Ser Thr Lys
         595                 600                 605            
 Thr Gly Thr Met Ala Ala Leu Arg Leu Ser His Lys Gly Asn Glu Phe
     610                 615                 620                
 Trp Gly Thr Thr Gln Thr Leu Asn Val Lys Phe Leu Pro Ser Asp Pro
 625                 630                 635                 640
 Asn His Phe Ile Ile Gly Thr Asp Met Glu Val Gln Pro Gly Lys Pro
                 645                 650                 655    
 Val Leu Gly Ala Trp Leu Thr Arg Arg Gly Ala Gly Asp Leu Val His
             660                 665                 670        
 Val Thr Glu Ala Leu Arg Gly Cys Phe Leu Ile Tyr Glu Met Trp Phe
         675                 680                 685            
 Phe Thr His Ser Arg Gly Glu Gln Gly Gly Thr Gln Ala Gly Ser Ser
     690                 695                 700                
 Ser Ser Glu Ile Asp Gln Gln Thr Thr Gly Cys Ser Gly Pro Ser Ser
 705                 710                 715                 720
 Gly Leu Glu Arg Thr Glu Ile Asn Lys Glu Leu Gly His Arg Gln Gly
                 725                 730                 735    
 Ala Arg Cys Arg Pro Gln His His Ala Val Ser Ala Ala Ala Leu Thr
             740                 745                 750        
 Val Asp Val Val Thr Ser Ser Leu Pro Glu Val Ala Pro Pro Gly Thr
         755                 760                 765            
 Val Ala Ser Ala Leu Cys Arg Glu Asp Ser Cys Ser Gln Thr Lys Gly
     770                 775                 780                
 Gly Gly Leu Gly Pro His Thr Val Pro Asp Ser Gly Ser Cys Trp Thr
 785                 790                 795                 800
 Arg Ile Leu His Gly Ala Asp Tyr Ala Asp Phe Ser Leu Val Asp Pro
                 805                 810                 815    
 Thr Ala Ala Ala Thr Glu Arg Trp Arg Gln Gly His Val Ala Val Ser
             820                 825                 830        
 Gln Glu Asn Ser Leu Tyr Ser Cys Arg Pro Leu Leu Ala Ala Ser Arg
         835                 840                 845            
 Ser Arg Arg Ser His Glu Arg Lys Thr Asp Leu Lys Asn His Leu Ser
     850                 855                 860                
 His Cys Leu Lys Ala Ile Ser Gln Ile Gln
 865                 870                



      <210> 874
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 874
 Met Phe Phe Pro Leu Phe Arg Leu Leu Leu Trp Asp Cys Asp Asp Arg
   1               5                  10                  15    
 Ser Tyr Ser Tyr Tyr Val Glu Val Ser Thr Asn Gln Gln Gln Trp Thr
              20                  25                  30        
 Met Val Ala Asp Arg Thr Lys Val Ser Cys Lys
          35                  40            



      <210> 875
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 875
 Met Gln Lys Ser Ser Ser Thr Arg Ala Gly Asp Met Arg Glu Lys Asp
   1               5                  10                  15    
 Thr Arg Gly Cys Arg Met Ser Ser Arg Ser Glu Cys Gly Asn Leu Thr
              20                  25                  30        
 Ser His Arg Ile Leu Ser Ser Gly Gly Ser Trp Thr Leu Gln Leu Leu
          35                  40                  45            
 Leu Tyr Ser Ser Leu Pro His Ser Glu Asn Gln Gln Arg Ser Glu Leu
      50                  55                  60                
 Pro Gln Met Thr Asp Gly Lys Tyr Pro Ala Trp Ser Trp Ile Thr Lys
  65                  70                  75                  80
 Leu Tyr Lys Leu
                



      <210> 876
      <211> 402
      <212> PRT
      <213> Homo sapiens


      <400> 876
 Met Glu Ala Arg Gly Glu Leu Gly Pro Ala Arg Glu Ser Ala Gly Gly
   1               5                  10                  15    
 Asp Leu Leu Leu Ala Leu Leu Ala Arg Arg Ala Asp Leu Arg Arg Glu
              20                  25                  30        
 Ile Pro Leu Cys Ala Gly Cys Asp Gln His Ile Leu Asp Arg Phe Ile
          35                  40                  45            
 Leu Lys Ala Leu Asp Arg His Trp His Ser Lys Cys Leu Lys Cys Ser
      50                  55                  60                
 Asp Cys His Thr Pro Leu Ala Glu Arg Cys Phe Ser Arg Gly Glu Ser
  65                  70                  75                  80
 Val Tyr Cys Lys Asp Asp Phe Phe Lys Arg Phe Gly Thr Lys Cys Ala
                  85                  90                  95    
 Ala Cys Gln Leu Gly Ile Pro Pro Thr Gln Val Val Arg Arg Ala Gln
             100                 105                 110        
 Asp Phe Val Tyr His Leu His Cys Phe Ala Cys Val Val Cys Lys Arg
         115                 120                 125            
 Gln Leu Ala Thr Gly Asp Glu Phe Tyr Leu Met Glu Asp Ser Arg Leu
     130                 135                 140                
 Val Cys Lys Ala Asp Tyr Glu Thr Ala Lys Gln Arg Glu Ala Glu Ala
 145                 150                 155                 160
 Thr Ala Lys Arg Pro Arg Thr Thr Ile Thr Ala Lys Gln Leu Glu Thr
                 165                 170                 175    
 Leu Lys Ser Ala Tyr Asn Thr Ser Pro Lys Pro Ala Arg His Val Arg
             180                 185                 190        
 Glu Gln Leu Ser Ser Glu Thr Gly Leu Asp Met Arg Val Val Gln Val
         195                 200                 205            
 Trp Phe Gln Asn Arg Arg Ala Lys Glu Lys Arg Leu Lys Lys Asp Ala
     210                 215                 220                
 Gly Arg Gln Arg Trp Gly Gln Tyr Phe Arg Asn Met Lys Arg Ser Arg
 225                 230                 235                 240
 Gly Gly Ser Lys Ser Asp Lys Asp Ser Val Gln Glu Gly Gln Asp Ser
                 245                 250                 255    
 Asp Ala Glu Val Ser Phe Pro Asp Glu Pro Ser Leu Ala Glu Met Gly
             260                 265                 270        
 Pro Ala Asn Gly Leu Tyr Gly Ser Leu Gly Glu Pro Thr Gln Ala Leu
         275                 280                 285            
 Gly Arg Pro Ser Gly Ala Leu Gly Asn Phe Ser Leu Glu His Gly Gly
     290                 295                 300                
 Leu Ala Gly Pro Glu Gln Tyr Arg Glu Leu Arg Pro Gly Ser Pro Tyr
 305                 310                 315                 320
 Gly Val Pro Pro Ser Pro Ala Ala Pro Gln Ser Leu Pro Gly Pro Gln
                 325                 330                 335    
 Pro Leu Leu Ser Ser Leu Val Tyr Pro Asp Thr Ser Leu Gly Leu Val
             340                 345                 350        
 Pro Ser Gly Ala Pro Gly Gly Pro Pro Pro Met Arg Val Leu Ala Gly
         355                 360                 365            
 Asn Gly Pro Ser Ser Asp Leu Ser Thr Gly Ser Ser Gly Gly Tyr Pro
     370                 375                 380                
 Asp Phe Pro Ala Ser Pro Ala Ser Trp Leu Asp Glu Val Asp His Ala
 385                 390                 395                 400
 Gln Phe
        



      <210> 877
      <211> 230
      <212> PRT
      <213> Homo sapiens


      <400> 877
 Met Ala Arg Val Lys Met Gly Asp Ile Met Lys Asn Ile Phe Ile Val
   1               5                  10                  15    
 Gln Ser Gln Thr Met Lys Leu Gln Val Phe Ile Ala Gln Leu His Leu
              20                  25                  30        
 Gln Gln Thr Cys Leu Phe Arg Thr Arg Lys Ser Cys Ser Met Ser Pro
          35                  40                  45            
 Gln Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln Lys Met Met Gly Asn
      50                  55                  60                
 Ile Ala Ala Val Ala Ala Ser Cys Ala Asn Asn Val Pro Ala Pro Val
  65                  70                  75                  80
 Leu Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile Ser Thr Thr Ser Val
                  85                  90                  95    
 Ser Ser Gln Asn Ala Ile Gln Pro Leu Phe Val Ser Pro Pro Thr His
             100                 105                 110        
 Gly Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro Cys His Ser Ala Ile
         115                 120                 125            
 Pro His Ala Gly Ala Ser Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro
     130                 135                 140                
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
 145                 150                 155                 160
 Pro Pro Ala Leu Asp Val Gly Glu Thr Ser Asn Leu Gln Pro Pro Pro
                 165                 170                 175    
 Pro Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro Ser Gly Ser Asp Leu
             180                 185                 190        
 Pro Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe Asn Leu Gly Leu Gln
         195                 200                 205            
 Cys Tyr Tyr His Ser Tyr Trp His Ser Trp Ser Met Cys His Arg Cys
     210                 215                 220                
 Ser Ser Ser Ser Phe Met
 225                 230



      <210> 878
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 878
 Met Glu Glu Gly Ser Ile Gly Arg Phe Ile Leu Asp Gln Ile Thr Glu
   1               5                  10                  15    
 Gly Gln Leu Asp Trp Ala Pro Leu Ser Ser Pro Phe Asp Ile Met Val
              20                  25                  30        
 Leu Glu Gly Pro Asn Gly Arg Lys Glu Tyr Pro Met Tyr Ser Gly Glu
          35                  40                  45            
 Lys Ala Tyr Ile Gln Gly Leu Lys Glu Lys Phe Pro Gln Glu Glu Ala
      50                  55                  60                
 Ile Ile Asp Lys Tyr Ile Lys Leu Val Lys Val Val Ser Ser Gly Ala
  65                  70                  75                  80
 Pro His Ala Ile Leu Leu Lys Phe Leu Pro Leu Pro Val Val Gln Leu
                  85                  90                  95    
 Leu Asp Arg Cys Gly Leu Leu Thr Arg Phe Ser Pro Phe Leu Gln Ala
             100                 105                 110        
 Ser Thr Gln Ser Leu Ala Glu Val Leu Gln Gln Leu Gly Ala Ser Ser
         115                 120                 125            
 Glu Leu Gln Ala Val Leu Ser Tyr Ile Phe Pro Thr Tyr Gly Val Thr
     130                 135                 140                
 Pro Asn His Ser Ala Phe Ser Met His Ala Leu Leu Val Asn His Tyr
 145                 150                 155                 160
 Met Lys Gly Gly Phe Tyr Pro Arg Gly Gly Ser Ser Glu Ile Ala Phe
                 165                 170                 175    
 His Thr Ile Pro Val Ile Gln Arg Ala Gly Gly Ala Val Leu Thr Lys
             180                 185                 190        
 Ala Thr Val Gln Ser Val Leu Leu Asp Ser Ala Gly Lys Ala Cys Gly
         195                 200                 205            
 Val Ser Val Lys Lys Gly His Glu Leu Val Asn Ile Tyr Cys Pro Ile
     210                 215                 220                
 Val Val Ser Asn Ala Gly Leu Phe Asn Thr Tyr Glu His Leu Leu Pro
 225                 230                 235                 240
 Gly Asn Ala Arg Cys Leu Pro Gly Val Lys Gln Gln Leu Gly Thr Val
                 245                 250                 255    
 Arg Pro Gly Leu Gly Met Thr Ser Val Phe Ile Cys Leu Arg Gly Thr
             260                 265                 270        
 Lys Glu Asp Leu His Leu Pro Ser Thr Asn Tyr Tyr Val Tyr Tyr Asp
         275                 280                 285            
 Thr Asp Met Asp Gln Ala Met Glu Arg Tyr Val Ser Met Pro Arg Glu
     290                 295                 300                
 Glu Ala Ala Glu His Ile Pro Leu Leu Phe Phe Ala Phe Pro Ser Ala
 305                 310                 315                 320
 Lys Asp Pro Thr Trp Glu Asp Arg Phe Pro Gly Arg Ser Thr Met Ile
                 325                 330                 335    
 Met Leu Ile Pro Thr Ala Tyr Glu Trp Phe Glu Glu Trp Gln Ala Glu
             340                 345                 350        
 Leu Lys Gly Lys Arg Gly Ser Asp Tyr Glu Thr Phe Lys Asn Ser Phe
         355                 360                 365            
 Val Glu Ala Ser Met Ser Val Val Leu Lys Leu Phe Pro Gln Leu Glu
     370                 375                 380                
 Gly Lys Val Glu Ser Val Thr Ala Gly Ser Pro Leu Thr Asn Gln Phe
 385                 390                 395                 400
 Tyr Leu Ala Ala Pro Arg Gly Ala Cys Tyr Gly Ala Asp His Asp Leu
                 405                 410                 415    
 Gly Arg Leu His Pro Cys Val Met Ala Ser Leu Arg Ala Gln Ser Pro
             420                 425                 430        
 Ile Pro Asn Leu Tyr Leu Thr Gly Gln Asp Ile Phe Thr Cys Gly Leu
         435                 440                 445            
 Val Gly Ala Leu Gln Gly Ala Leu Leu Cys Ser Ser Thr Ile Leu Lys
     450                 455                 460                
 Arg Asn Leu Tyr Ser Asp Leu Lys Asn Leu Asp Ser Arg Ile Arg Ala
 465                 470                 475                 480
 Gln Lys Lys Lys Asn
                 485



      <210> 879
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 879
 Met Glu Lys Leu Arg Glu Lys Val Pro Phe Gln Asn Arg Gly Lys Gly
   1               5                  10                  15    
 Thr Leu Ser Ser Ile Ile Pro Asn Asn Ser Asp Thr Arg Lys Ala Thr
              20                  25                  30        
 Glu Thr Thr Ser Leu Ser Ser Lys Pro Glu Tyr Val Asn Pro Asp Phe
          35                  40                  45            
 Arg Trp Ser Lys Asp Pro Ser Ser Lys Ser Gly Asn Leu Leu Glu Thr
      50                  55                  60                
 Ser Glu Val Gly Trp Thr Ser Asn Pro Glu Glu Leu Asp Pro Ile Arg
  65                  70                  75                  80
 Leu Ala Leu Leu Gly Lys Ser Gly Leu Ser Cys Gln Val Gly Ser Ala
                  85                  90                  95    
 Thr Ser His Pro Val Ser Cys Gln Glu Pro Ile Asp Glu Asp Gln Arg
             100                 105                 110        
 Ile Ser Pro Lys Asp Lys Ser Thr Ala Gly Arg Glu Phe Ser Gly Gln
         115                 120                 125            
 Val Ser His Gln Thr Thr Ser Glu Asn Gln Cys Thr Pro Ile Pro Ser
     130                 135                 140                
 Ser Thr Val His Ser Ser Val Ala Asp Met Gln Asn Met Pro Ala Ala
 145                 150                 155                 160
 Val His Ala Leu Leu Thr Gln Pro Ser Leu Ser Ala Ala Pro Phe Ala
                 165                 170                 175    
 Gln Arg Tyr Leu Gly Thr Leu Pro Ser Thr Gly Ser Thr Thr Leu Pro
             180                 185                 190        
 Gln Cys His Ala Gly Asn Ala Thr Val Cys Gly Phe Ser Gly Gly Leu
         195                 200                 205            
 Pro Tyr Pro Ala Val Ala Gly Glu Pro Val Gln Asn Ser Val Ala Val
     210                 215                 220                
 Gly Ile Cys Leu Gly Ser Asn Ile Gly Ser Gly Trp Met Gly Thr Ser
 225                 230                 235                 240
 Ser Leu Cys Asn Pro Tyr Ser Asn Thr Leu Asn Gln Asn Leu Leu Ser
                 245                 250                 255    
 Thr Thr Lys Pro Phe Pro Val Pro Ser Val Gly Thr Asn Cys Gly Ile
             260                 265                 270        
 Glu Pro Trp Asp Ser Gly Val Thr Ser Gly Leu Gly Ser Val Arg Val
         275                 280                 285            
 Pro Glu Glu Leu Lys Leu Pro His Ala Cys Cys Val Gly Ile Ala Ser
     290                 295                 300                
 Gln Thr Leu Leu Ser Val Leu Asn Pro Thr Asp Arg Trp Leu Gln Val
 305                 310                 315                 320
 Ser Ile Gly Val Leu Ser Ile Ser Val Asn Gly Glu Lys Val Ala Phe
                 325                 330                 335    
 Tyr Val Phe Leu Ile
             340    



      <210> 880
      <211> 620
      <212> PRT
      <213> Homo sapiens


      <400> 880
 Met Ala Ala Ala Thr Ala Asp Pro Gly Ala Gly Asn Pro Gln Pro Gly
   1               5                  10                  15    
 Asp Ser Ser Gly Gly Gly Ala Gly Gly Gly Leu Pro Ser Pro Gly Glu
              20                  25                  30        
 Gln Glu Leu Ser Arg Arg Leu Gln Arg Leu Tyr Pro Ala Val Asn Gln
          35                  40                  45            
 Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys Tyr Asn
      50                  55                  60                
 Tyr Ile Gly Leu Ser Gln Gly Asn Leu Arg Val His Tyr Lys Gly His
  65                  70                  75                  80
 Gly Lys Asn His Lys Asp Ala Ala Ser Val Arg Ala Thr His Pro Ile
                  85                  90                  95    
 Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val Ser Lys
             100                 105                 110        
 Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn
         115                 120                 125            
 Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly
     130                 135                 140                
 Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly
 145                 150                 155                 160
 Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile
                 165                 170                 175    
 Asn Gly Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala
             180                 185                 190        
 Phe Thr Asp Leu Pro Ala Asn Leu Tyr Pro Thr Val Gly Leu Gln Thr
         195                 200                 205            
 Pro Gly Glu Ile Val Asp Ala Asn Phe Gly Gln Gln Pro Phe Leu Phe
     210                 215                 220                
 Asp Ile Glu Asp Tyr Met Arg Glu Trp Arg Ala Lys Val Gln Gly Thr
 225                 230                 235                 240
 Val His Cys Phe Pro Ile Ser Ala Arg Leu Gly Glu Trp Gln Ala Val
                 245                 250                 255    
 Leu Gln Asn Met Val Ser Ser Tyr Leu Val His His Gly Tyr Cys Ala
             260                 265                 270        
 Thr Ala Thr Ala Phe Ala Arg Met Thr Glu Thr Pro Ile Gln Glu Glu
         275                 280                 285            
 Gln Ala Ser Ile Lys Asn Arg Gln Lys Ile Gln Lys Leu Val Leu Glu
     290                 295                 300                
 Gly Arg Val Gly Glu Ala Ile Glu Thr Thr Gln Arg Phe Tyr Pro Gly
 305                 310                 315                 320
 Leu Leu Glu His Asn Pro Asn Leu Leu Phe Met Leu Lys Cys Arg Gln
                 325                 330                 335    
 Phe Val Glu Met Val Asn Gly Thr Asp Ser Glu Val Arg Ser Leu Ser
             340                 345                 350        
 Ser Arg Ser Pro Lys Ser Gln Asp Ser Tyr Pro Gly Ser Pro Ser Leu
         355                 360                 365            
 Ser Pro Arg His Gly Pro Ser Ser Ser His Met His Asn Thr Gly Ala
     370                 375                 380                
 Asp Ser Pro Ser Cys Ser Asn Gly Val Ala Ser Thr Lys Ser Lys Gln
 385                 390                 395                 400
 Asn His Ser Lys Tyr Pro Ala Pro Ser Ser Ser Ser Ser Ser Ser Ser
                 405                 410                 415    
 Ser Ser Ser Ser Ser Ser Pro Ser Ser Val Asn Tyr Ser Glu Ser Asn
             420                 425                 430        
 Ser Thr Asp Ser Thr Lys Ser Gln His His Ser Ser Thr Ser Asn Gln
         435                 440                 445            
 Glu Thr Ser Asp Ser Glu Met Glu Met Glu Ala Glu His Tyr Pro Asn
     450                 455                 460                
 Gly Val Leu Gly Ser Met Ser Thr Arg Ile Val Asn Gly Ala Tyr Lys
 465                 470                 475                 480
 His Glu Asp Leu Gln Thr Asp Glu Ser Ser Met Asp Asp Arg His Pro
                 485                 490                 495    
 Arg Arg Gln Leu Cys Gly Gly Asn Gln Ala Ala Thr Glu Arg Ile Ile
             500                 505                 510        
 Leu Phe Gly Arg Glu Leu Gln Ala Leu Ser Glu Gln Leu Gly Arg Glu
         515                 520                 525            
 Tyr Gly Lys Asn Leu Ala His Thr Glu Met Leu Gln Asp Ala Phe Ser
     530                 535                 540                
 Leu Leu Ala Tyr Ser Asp Pro Trp Ser Cys Pro Val Gly Gln Gln Leu
 545                 550                 555                 560
 Asp Pro Ile Gln Arg Glu Pro Val Cys Ala Ala Leu Asn Ser Ala Ile
                 565                 570                 575    
 Leu Glu Ser Gln Asn Leu Pro Lys Gln Pro Pro Leu Met Leu Ala Leu
             580                 585                 590        
 Gly Gln Ala Ser Glu Cys Leu Arg Leu Met Ala Arg Ala Gly Leu Gly
         595                 600                 605            
 Ser Cys Ser Phe Ala Arg Val Asp Asp Tyr Leu His
     610                 615                 620



      <210> 881
      <211> 659
      <212> PRT
      <213> Homo sapiens


      <400> 881
 Met Ala Ala Ala Thr Ala Asp Pro Gly Ala Gly Asn Pro Gln Pro Gly
   1               5                  10                  15    
 Asp Ser Ser Gly Gly Gly Ala Gly Gly Gly Leu Pro Ser Pro Gly Glu
              20                  25                  30        
 Gln Glu Leu Ser Arg Arg Leu Gln Arg Leu Tyr Pro Ala Val Asn Gln
          35                  40                  45            
 Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys Tyr Asn
      50                  55                  60                
 Tyr Ile Gly Leu Ser Gln Gly Asn Leu Arg Val His Tyr Lys Gly His
  65                  70                  75                  80
 Gly Lys Asn His Lys Asp Ala Ala Ser Val Arg Ala Thr His Pro Ile
                  85                  90                  95    
 Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val Ser Lys
             100                 105                 110        
 Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn
         115                 120                 125            
 Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly
     130                 135                 140                
 Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly
 145                 150                 155                 160
 Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile
                 165                 170                 175    
 Asn Gly Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala
             180                 185                 190        
 Phe Thr Asp Leu Pro Gly Leu Thr Leu Val Thr Lys Ala Gly Leu Gln
         195                 200                 205            
 Trp Gln Asn His Ser Leu Leu Gln Pro Gln Phe Pro Gly Leu Lys Pro
     210                 215                 220                
 Ser Ser His Leu Ser Leu Pro Ser Ser Trp Asp His Arg Asn Leu Tyr
 225                 230                 235                 240
 Pro Thr Val Gly Leu Gln Thr Pro Gly Glu Ile Val Asp Ala Asn Phe
                 245                 250                 255    
 Gly Gln Gln Pro Phe Leu Phe Asp Ile Glu Asp Tyr Met Arg Glu Trp
             260                 265                 270        
 Arg Ala Lys Val Gln Gly Thr Val His Cys Phe Pro Ile Ser Ala Arg
         275                 280                 285            
 Leu Gly Glu Trp Gln Ala Val Leu Gln Asn Met Val Ser Ser Tyr Leu
     290                 295                 300                
 Val His His Gly Tyr Cys Ala Thr Ala Thr Ala Phe Ala Arg Met Thr
 305                 310                 315                 320
 Glu Thr Pro Ile Gln Glu Glu Gln Ala Ser Ile Lys Asn Arg Gln Lys
                 325                 330                 335    
 Ile Gln Lys Leu Val Leu Glu Gly Arg Val Gly Glu Ala Ile Glu Thr
             340                 345                 350        
 Thr Gln Arg Phe Tyr Pro Gly Leu Leu Glu His Asn Pro Asn Leu Leu
         355                 360                 365            
 Phe Met Leu Lys Cys Arg Gln Phe Val Glu Met Val Asn Gly Thr Asp
     370                 375                 380                
 Ser Glu Val Arg Ser Leu Ser Ser Arg Ser Pro Lys Ser Gln Asp Ser
 385                 390                 395                 400
 Tyr Pro Gly Ser Pro Ser Leu Ser Pro Arg His Gly Pro Ser Ser Ser
                 405                 410                 415    
 His Met His Asn Thr Gly Ala Asp Ser Pro Ser Cys Ser Asn Gly Val
             420                 425                 430        
 Ala Ser Thr Lys Ser Lys Gln Asn His Ser Lys Tyr Pro Ala Pro Ser
         435                 440                 445            
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Ser
     450                 455                 460                
 Val Asn Tyr Ser Glu Ser Asn Ser Thr Asp Ser Thr Lys Ser Gln His
 465                 470                 475                 480
 His Ser Ser Thr Ser Asn Gln Glu Thr Ser Asp Ser Glu Met Glu Met
                 485                 490                 495    
 Glu Ala Glu His Tyr Pro Asn Gly Val Leu Gly Ser Met Ser Thr Arg
             500                 505                 510        
 Ile Val Asn Gly Ala Tyr Lys His Glu Asp Leu Gln Thr Asp Glu Ser
         515                 520                 525            
 Ser Met Asp Asp Arg His Pro Arg Arg Gln Leu Cys Gly Gly Asn Gln
     530                 535                 540                
 Ala Ala Thr Glu Arg Ile Ile Leu Phe Gly Arg Glu Leu Gln Ala Leu
 545                 550                 555                 560
 Ser Glu Gln Leu Gly Arg Glu Tyr Gly Lys Asn Leu Ala His Thr Glu
                 565                 570                 575    
 Met Leu Gln Asp Ala Phe Ser Leu Leu Ala Tyr Ser Asp Pro Trp Ser
             580                 585                 590        
 Cys Pro Val Gly Gln Gln Leu Asp Pro Ile Gln Arg Glu Pro Val Cys
         595                 600                 605            
 Ala Ala Leu Asn Ser Ala Ile Leu Glu Ser Gln Asn Leu Pro Lys Gln
     610                 615                 620                
 Pro Pro Leu Met Leu Ala Leu Gly Gln Ala Ser Glu Cys Leu Arg Leu
 625                 630                 635                 640
 Met Ala Arg Ala Gly Leu Gly Ser Cys Ser Phe Ala Arg Val Asp Asp
                 645                 650                 655    
 Tyr Leu His
            



      <210> 882
      <211> 1595
      <212> PRT
      <213> Homo sapiens


      <400> 882
 Met Glu Ser His Pro Pro Ile Pro Pro Val Phe Val Glu His Met Val
   1               5                  10                  15    
 Pro Gln Asp Ala Asn Gln Lys Gly Leu Cys Thr Lys Glu Arg Met Ile
              20                  25                  30        
 Cys Leu Glu Phe Thr Ser Arg Glu Phe His Ala Gly Gln Ile Glu Asp
          35                  40                  45            
 Glu Leu Asn Leu Asn Asp Ile Asn Gly Cys Ser Ser Gly Cys Cys Leu
      50                  55                  60                
 Asn Glu Ser Lys Phe Pro Leu Asp Asn Cys His Ala Ser Lys Ala Leu
  65                  70                  75                  80
 Ile Gln Pro Gly His Val Pro Glu Met Ala Asn Lys Phe Pro Asp Leu
                  85                  90                  95    
 Thr Val Glu Asp Leu Glu Thr Asp Ala Leu Lys Ala Asp Met Asn Val
             100                 105                 110        
 His Leu Leu Pro Met Glu Glu Leu Thr Ser Pro Leu Lys Asp Pro Pro
         115                 120                 125            
 Met Ser Pro Asp Pro Glu Ser Pro Ser Pro Gln Pro Ser Cys Gln Thr
     130                 135                 140                
 Glu Ile Ser Asp Phe Ser Thr Asp Arg Ile Asp Phe Phe Ser Ala Leu
 145                 150                 155                 160
 Glu Lys Phe Val Glu Leu Ser Gln Glu Thr Arg Ser Arg Ser Phe Ser
                 165                 170                 175    
 His Ser Arg Met Glu Glu Leu Gly Gly Gly Arg Asn Glu Ser Cys Arg
             180                 185                 190        
 Leu Ser Val Val Glu Val Ala Pro Ser Lys Val Thr Ala Asp Asp Gln
         195                 200                 205            
 Arg Ser Ser Ser Leu Ser Asn Thr Pro His Ala Ser Glu Glu Ser Ser
     210                 215                 220                
 Met Asp Glu Glu Gln Ser Lys Ala Ile Ser Glu Leu Val Ser Pro Asp
 225                 230                 235                 240
 Ile Phe Met Gln Ser His Ser Glu Asn Ala Ile Ser Val Lys Glu Ile
                 245                 250                 255    
 Val Thr Glu Ile Glu Ser Ile Ser Gln Gly Val Gly Gln Ile Gln Leu
             260                 265                 270        
 Lys Gly Asp Ile Leu Pro Asn Pro Cys His Thr Pro Lys Lys Asn Ser
         275                 280                 285            
 Ile His Glu Leu Leu Leu Glu Arg Ala Gln Thr Pro Glu Asn Lys Pro
     290                 295                 300                
 Gly His Met Glu Gln Asp Glu Asp Ser Cys Thr Ala Gln Pro Glu Leu
 305                 310                 315                 320
 Ala Lys Asp Ser Gly Met Cys Asn Pro Glu Gly Cys Leu Thr Thr His
                 325                 330                 335    
 Ser Ser Ile Ala Asp Leu Glu Glu Gly Glu Pro Ala Glu Gly Glu Gln
             340                 345                 350        
 Glu Leu Gln Gly Ser Gly Met His Pro Gly Ala Lys Trp Tyr Pro Gly
         355                 360                 365            
 Ser Val Arg Arg Ala Thr Leu Glu Phe Glu Glu Arg Leu Arg Gln Glu
     370                 375                 380                
 Gln Glu His His Gly Ala Ala Pro Thr Cys Thr Ser Leu Ser Thr Arg
 385                 390                 395                 400
 Lys Asn Ser Lys Asn Asp Ser Ser Val Ala Asp Leu Ala Pro Lys Gly
                 405                 410                 415    
 Lys Ser Asp Glu Ala Pro Pro Glu His Ser Phe Val Leu Lys Glu Pro
             420                 425                 430        
 Glu Met Ser Lys Gly Lys Gly Lys Tyr Ser Gly Ser Glu Ala Gly Ser
         435                 440                 445            
 Leu Ser His Ser Glu Gln Asn Ala Thr Val Pro Ala Pro Arg Val Leu
     450                 455                 460                
 Glu Phe Asp His Leu Pro Asp Pro Gln Glu Gly Pro Gly Ser Asp Thr
 465                 470                 475                 480
 Gly Thr Gln Gln Glu Gly Val Leu Lys Asp Leu Arg Thr Val Ile Pro
                 485                 490                 495    
 Tyr Gln Glu Ser Glu Thr Gln Ala Val Pro Leu Pro Leu Pro Lys Arg
             500                 505                 510        
 Val Glu Ile Ile Glu Tyr Thr His Ile Val Thr Ser Pro Asn His Thr
         515                 520                 525            
 Gly Pro Gly Ser Glu Ile Ala Thr Ser Glu Lys Ser Gly Glu Gln Gly
     530                 535                 540                
 Leu Arg Lys Val Asn Met Glu Lys Ser Val Thr Val Leu Cys Thr Leu
 545                 550                 555                 560
 Asp Glu Asn Leu Asn Arg Thr Leu Asp Pro Asn Gln Val Ser Leu His
                 565                 570                 575    
 Pro Gln Val Leu Pro Leu Pro His Ser Ser Ser Pro Glu His Asn Arg
             580                 585                 590        
 Pro Thr Asp His Pro Thr Ser Ile Leu Ser Ser Pro Glu Asp Arg Gly
         595                 600                 605            
 Ser Ser Leu Ser Thr Ala Leu Glu Thr Ala Ala Pro Phe Val Ser His
     610                 615                 620                
 Thr Thr His Leu Leu Ser Ala Ser Leu Asp Tyr Leu His Pro Gln Thr
 625                 630                 635                 640
 Met Val His Leu Glu Gly Phe Thr Glu Gln Ser Ser Thr Thr Asp Glu
                 645                 650                 655    
 Pro Ser Ala Glu Gln Val Ser Trp Glu Glu Ser Gln Glu Ser Pro Leu
             660                 665                 670        
 Ser Ser Gly Ser Glu Val Pro Tyr Lys Asp Ser Gln Leu Ser Ser Ala
         675                 680                 685            
 Asp Leu Ser Leu Ile Ser Lys Leu Gly Asp Asn Thr Gly Glu Leu Gln
     690                 695                 700                
 Glu Lys Met Asp Pro Leu Pro Val Ala Cys Arg Leu Pro His Ser Ser
 705                 710                 715                 720
 Ser Ser Glu Asn Ile Lys Ser Leu Ser His Ser Pro Gly Val Val Lys
                 725                 730                 735    
 Glu Arg Ala Lys Glu Ile Glu Ser Arg Val Val Phe Gln Ala Gly Leu
             740                 745                 750        
 Thr Lys Pro Ser Gln Met Arg Arg Ser Ala Ser Leu Ala Lys Leu Gly
         755                 760                 765            
 Tyr Leu Asp Leu Cys Lys Asp Cys Leu Pro Glu Arg Glu Pro Ala Ser
     770                 775                 780                
 Cys Glu Ser Pro His Leu Lys Leu Leu Gln Pro Phe Leu Arg Thr Asp
 785                 790                 795                 800
 Ser Gly Met His Ala Met Glu Asp Gln Glu Ser Leu Glu Asn Pro Gly
                 805                 810                 815    
 Ala Pro His Asn Pro Glu Pro Thr Lys Ser Phe Val Glu Gln Leu Thr
             820                 825                 830        
 Thr Thr Glu Cys Ile Val Gln Ser Lys Pro Val Glu Arg Pro Leu Val
         835                 840                 845            
 Gln Tyr Ala Lys Glu Phe Gly Ser Ser Gln Gln Tyr Leu Leu Pro Arg
     850                 855                 860                
 Ala Gly Leu Glu Leu Thr Ser Ser Glu Gly Gly Leu Pro Val Leu Gln
 865                 870                 875                 880
 Thr Gln Gly Leu Gln Pro Glu Ala Ser Asn Gly Leu Lys Val Ser Gln
                 885                 890                 895    
 Lys Ser Glu Gly Ser Gln Pro Ser Ser Ser Arg Ser Pro Leu Glu Phe
             900                 905                 910        
 Leu Lys Glu Ala Glu Ser Arg Arg Ile Gly Gln Ser Ala Glu Leu Asp
         915                 920                 925            
 Thr Arg Val Pro Asp Thr Thr Asp Thr Arg Arg Gly Gly Ser Phe Ala
     930                 935                 940                
 Leu Lys Pro Ser Ser Ala Pro Tyr Ala Leu Gly Pro Leu Pro Gln Arg
 945                 950                 955                 960
 Ile Arg Ser Val Ser Ala Pro Gln Pro Ala Gln Asp Gln Met Arg Val
                 965                 970                 975    
 Arg Tyr Pro Val Val Ala Ala Val Leu Ala Pro Tyr Leu Ala Leu Ser
             980                 985                 990        
 Gln Asp Pro Met Val Lys Ser Ser Ala Ser Gly Gln Gly Ala Ser Gly
         995                1000                1005            
 Ser Tyr Asn His Val Arg Glu Glu Met Leu Ile Lys Ala Gly Gly Ala
    1010                1015                1020                
 Met Ser Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly
1025                1030                1035                1040
 Gln Ala Ala Lys Ala Asp Gln Ala Tyr Glu Asp Ile Arg Val Ser Lys
                1045                1050                1055    
 Val Thr Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Lys Phe Leu Ala
            1060                1065                1070        
 Ile Ile Val Glu Ala Gly Gly Gly Gly Ala Phe Ile Val Leu Pro Leu
        1075                1080                1085            
 Ala Lys Thr Gly Arg Val Asp Lys Asn Tyr Pro Leu Val Thr Gly His
    1090                1095                1100                
 Thr Ala Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Asn Val
1105                1110                1115                1120
 Ile Ala Ser Ala Ser Asp Asp Thr Thr Ile Met Val Trp Gln Ile Pro
                1125                1130                1135    
 Asp Tyr Thr Pro Met Arg Asn Ile Thr Glu Pro Ile Ile Thr Leu Glu
            1140                1145                1150        
 Gly His Ser Lys Arg Val Gly Ile Leu Ser Trp His Pro Thr Ala Arg
        1155                1160                1165            
 Asn Val Leu Leu Ser Ala Gly Gly Asp Asn Val Ile Ile Ile Trp Asn
    1170                1175                1180                
 Val Gly Thr Gly Glu Val Leu Leu Ser Leu Asp Asp Met His Pro Asp
1185                1190                1195                1200
 Val Ile His Ser Val Cys Trp Asn Ser Asn Gly Ser Leu Leu Ala Thr
                1205                1210                1215    
 Thr Cys Lys Asp Lys Thr Leu Arg Ile Ile Asp Pro Arg Lys Gly Gln
            1220                1225                1230        
 Val Val Ala Glu Gln Ala Arg Pro His Glu Gly Ala Arg Pro Leu Arg
        1235                1240                1245            
 Ala Val Phe Thr Ala Asp Gly Lys Leu Leu Ser Thr Gly Phe Ser Arg
    1250                1255                1260                
 Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Arg Phe Ala Ala
1265                1270                1275                1280
 His Glu Gly Met Arg Pro Met Arg Ala Val Phe Thr Arg Gln Gly His
                1285                1290                1295    
 Ile Phe Thr Thr Gly Phe Thr Arg Met Ser Gln Arg Glu Leu Gly Leu
            1300                1305                1310        
 Trp Asp Pro Asn Asn Phe Glu Glu Pro Val Ala Leu Gln Glu Met Asp
        1315                1320                1325            
 Thr Ser Asn Gly Val Leu Leu Pro Phe Tyr Asp Pro Asp Ser Ser Ile
    1330                1335                1340                
 Val Tyr Leu Cys Gly Lys Val Leu Thr Ala Gly Gln Gly Glu Gln Gly
1345                1350                1355                1360
 Thr Gly Trp Arg Cys Gly Gly Pro Cys Pro Gly Ala Pro Leu Asn Arg
                1365                1370                1375    
 Leu Ile Leu Gln Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp
            1380                1385                1390        
 Glu Pro Pro Phe Val His Tyr Leu Asn Thr Phe Ser Ser Lys Glu Pro
        1395                1400                1405            
 Gln Arg Gly Met Gly Phe Met Pro Lys Arg Gly Leu Asp Val Ser Lys
    1410                1415                1420                
 Cys Glu Ile Ala Arg Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro
1425                1430                1435                1440
 Ile Ile Met Thr Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu
                1445                1450                1455    
 Tyr Pro Asp Thr Pro Gly Pro Glu Pro Ala Leu Glu Ala Asp Glu Trp
            1460                1465                1470        
 Leu Ser Gly Gln Asp Ala Glu Pro Val Leu Ile Ser Leu Arg Asp Gly
        1475                1480                1485            
 Tyr Val Pro Pro Lys His Arg Glu Leu Arg Val Thr Lys Arg Asn Ile
    1490                1495                1500                
 Leu Asp Val Arg Pro Pro Ser Gly Pro Arg Arg Ser Gln Ser Ala Ser
1505                1510                1515                1520
 Asp Ala Pro Leu Ser Val Arg Ser Ala Leu Leu His Ser Gly Pro Ile
                1525                1530                1535    
 Tyr Ile Ser Pro Asn Arg Pro Tyr Thr Thr Arg Pro Leu Cys Pro Pro
            1540                1545                1550        
 Pro Gln Gln Gln His Thr Leu Glu Thr Leu Leu Glu Glu Ile Lys Ala
        1555                1560                1565            
 Leu Arg Glu Arg Val Gln Ala Gln Glu Gln Arg Ile Thr Ala Leu Glu
    1570                1575                1580                
 Asn Met Leu Cys Glu Leu Val Asp Gly Thr Asp
1585                1590                1595



      <210> 883
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 883
 Met Ala Glu Thr Ser Glu Glu Val Ala Val Leu Val Gln Arg Val Val
   1               5                  10                  15    
 Lys Asp Ile Thr Asn Ala Phe Arg Arg Asn Pro His Ile Asp Glu Ile
              20                  25                  30        
 Gly Leu Ile Pro Cys Pro Glu Ala Arg Tyr Asn Arg Ser Pro Ile Val
          35                  40                  45            
 Leu Val Glu Asn Lys Leu Gly Val Glu Ser Trp Cys Val Lys Phe Leu
      50                  55                  60                
 Leu Pro Tyr Val His Asn Lys Leu Leu Leu Tyr Arg Thr Arg Lys Gln
  65                  70                  75                  80
 Trp Leu Asn Arg Asp Glu Leu Ile Asp Val Thr Cys Thr Leu Leu Leu
                  85                  90                  95    
 Leu Asn Pro Asp Phe Thr Thr Ala Trp Asn Val Arg Tyr Val Ile Phe
             100                 105                 110        
 Ile Ser Asp Met Ile Lys Phe Val Gln Ile Ser Glu Asp Met Lys Glu
         115                 120                 125            
 Leu Ile Leu Ser Gly Thr Leu Asn Pro Ile Lys Asp Leu His Leu Gly
     130                 135                 140                
 Lys Leu Ala Leu Thr Lys Phe Pro Lys Ser Pro Glu Thr Trp Ile His
 145                 150                 155                 160
 Arg Arg Trp Val Leu Gln Gln Leu Ile Gln Glu Thr Ser Leu Pro Ser
                 165                 170                 175    
 Phe Val Thr Lys Gly Asn Leu Gly Thr Ile Pro Thr Glu Arg Ala Gln
             180                 185                 190        
 Arg Leu Ile Gln Glu Glu Met Glu Val Cys Gly Glu Ala Ala Gly Arg
         195                 200                 205            
 Tyr Pro Ser Asn Tyr Asn Ala Trp Ser His Arg Ile Trp Val Leu Gln
     210                 215                 220                
 His Leu Ala Lys Leu Asp Val Lys Ile Leu Leu Asp Glu Leu Ser Ser
 225                 230                 235                 240
 Thr Lys His Trp Ala Ser Met His Val Ser Asp His Ser Gly Phe His
                 245                 250                 255    
 Tyr Arg Gln Phe Leu Leu Lys Ser Leu Ile Ser Gln Thr Val Ile Asp
             260                 265                 270        
 Ser Ser Val Met Glu Gln Asn Pro Leu Arg Ser Glu Pro Ala Leu Val
         275                 280                 285            
 Pro Pro Lys Asp Glu Glu Ala Ala Val Ser Thr Glu Glu Pro Arg Ile
     290                 295                 300                
 Asn Leu Pro His Leu Leu Glu Glu Glu Val Glu Phe Ser Thr Asp Leu
 305                 310                 315                 320
 Ile Asp Ser Tyr Pro Gly His Glu Thr Leu Trp Cys His Arg Arg His
                 325                 330                 335    
 Ile Phe Tyr Leu Gln His His Leu Asn Gly Arg Phe Pro His Ser Met
             340                 345                 350        
 Thr Gln Leu Ser Pro Ala Asp Ser Pro Gly Gly Thr Leu Ser Asp Leu
         355                 360                 365            
 His Leu Ile Pro Ala Gly Ser Gln Leu Ser Gln Ala Met Glu Val Asp
     370                 375                 380                
 Gly Leu Asn Asp Ser Ser Lys Gln Gly Tyr Ser Gln Glu Thr Lys Arg
 385                 390                 395                 400
 Leu Lys Arg Thr Pro Val Pro Asp Ser Leu Gly Leu Glu Met Glu His
                 405                 410                 415    
 Arg Phe Ile Asp Gln Val Leu Ser Thr Cys Arg Asn Val Glu Gln Ala
             420                 425                 430        
 Arg Phe Ala Ser Ala Tyr Arg Lys Trp Leu Val Thr Leu Ser Gln
         435                 440                 445        



      <210> 884
      <211> 429
      <212> PRT
      <213> Homo sapiens


      <400> 884
 Met Ala Glu Thr Ser Glu Glu Val Ala Val Leu Val Gln Arg Val Val
   1               5                  10                  15    
 Lys Asp Ile Thr Asn Ala Phe Arg Arg Asn Pro His Ile Asp Glu Ile
              20                  25                  30        
 Gly Leu Ile Pro Cys Pro Glu Ala Arg Tyr Asn Arg Ser Pro Ile Val
          35                  40                  45            
 Leu Val Glu Asn Lys Leu Gly Val Glu Ser Trp Cys Val Lys Phe Leu
      50                  55                  60                
 Leu Pro Tyr Val His Asn Lys Leu Leu Leu Tyr Arg Thr Arg Lys Gln
  65                  70                  75                  80
 Trp Leu Asn Arg Asp Glu Leu Ile Asp Val Thr Cys Thr Leu Leu Leu
                  85                  90                  95    
 Leu Asn Pro Asp Phe Thr Thr Ala Trp Asn Val Arg Lys Glu Leu Ile
             100                 105                 110        
 Leu Ser Gly Thr Leu Asn Pro Ile Lys Asp Leu His Leu Gly Lys Leu
         115                 120                 125            
 Ala Leu Thr Lys Phe Pro Lys Ser Pro Glu Thr Trp Ile His Arg Arg
     130                 135                 140                
 Trp Val Leu Gln Gln Leu Ile Gln Glu Thr Ser Leu Pro Ser Phe Val
 145                 150                 155                 160
 Thr Lys Gly Asn Leu Gly Thr Ile Pro Thr Glu Arg Ala Gln Arg Leu
                 165                 170                 175    
 Ile Gln Glu Glu Met Glu Val Cys Gly Glu Ala Ala Gly Arg Tyr Pro
             180                 185                 190        
 Ser Asn Tyr Asn Ala Trp Ser His Arg Ile Trp Val Leu Gln His Leu
         195                 200                 205            
 Ala Lys Leu Asp Val Lys Ile Leu Leu Asp Glu Leu Ser Ser Thr Lys
     210                 215                 220                
 His Trp Ala Ser Met His Val Ser Asp His Ser Gly Phe His Tyr Arg
 225                 230                 235                 240
 Gln Phe Leu Leu Lys Ser Leu Ile Ser Gln Thr Val Ile Asp Ser Ser
                 245                 250                 255    
 Val Met Glu Gln Asn Pro Leu Arg Ser Glu Pro Ala Leu Val Pro Pro
             260                 265                 270        
 Lys Asp Glu Glu Ala Ala Val Ser Thr Glu Glu Pro Arg Ile Asn Leu
         275                 280                 285            
 Pro His Leu Leu Glu Glu Glu Val Glu Phe Ser Thr Asp Leu Ile Asp
     290                 295                 300                
 Ser Tyr Pro Gly His Glu Thr Leu Trp Cys His Arg Arg His Ile Phe
 305                 310                 315                 320
 Tyr Leu Gln His His Leu Asn Gly Arg Phe Pro His Ser Met Thr Gln
                 325                 330                 335    
 Leu Ser Pro Ala Asp Ser Pro Gly Gly Thr Leu Ser Asp Leu His Leu
             340                 345                 350        
 Ile Pro Ala Gly Ser Gln Leu Ser Gln Ala Met Glu Val Asp Gly Leu
         355                 360                 365            
 Asn Asp Ser Ser Lys Gln Gly Tyr Ser Gln Glu Thr Lys Arg Leu Lys
     370                 375                 380                
 Arg Thr Pro Val Pro Asp Ser Leu Gly Leu Glu Met Glu His Arg Phe
 385                 390                 395                 400
 Ile Asp Gln Val Leu Ser Thr Cys Arg Asn Val Glu Gln Ala Arg Phe
                 405                 410                 415    
 Ala Ser Ala Tyr Arg Lys Trp Leu Val Thr Leu Ser Gln
             420                 425                



      <210> 885
      <211> 33
      <212> PRT
      <213> Homo sapiens


      <400> 885
 Met Gly Glu Glu His Glu Gln Gln Met Asn Lys Tyr Gly Glu Glu Ala
   1               5                  10                  15    
 Pro Glu Phe Ser Asn Gly Cys Ser Val Thr Gly Leu Pro Gln Phe Thr
              20                  25                  30        
 Gly
    



      <210> 886
      <211> 63
      <212> PRT
      <213> Homo sapiens


      <400> 886
 Met Leu Gly Gln Ser Ile Arg Arg Val Thr Thr Ser Val Val Arg Arg
   1               5                  10                  15    
 Ser His Tyr Glu Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu
              20                  25                  30        
 Asn Lys Trp Ser Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala
          35                  40                  45            
 Cys Ala Thr Pro Phe Arg Val Val Arg His Gln Leu Leu Glu Thr
      50                  55                  60            



      <210> 887
      <211> 484
      <212> PRT
      <213> Homo sapiens


      <400> 887
 Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser Asp
   1               5                  10                  15    
 Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser Leu
              20                  25                  30        
 Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met Gln
          35                  40                  45            
 Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly Leu
      50                  55                  60                
 Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile Val
  65                  70                  75                  80
 Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys Asn
                  85                  90                  95    
 Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala Ile
             100                 105                 110        
 Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp Trp
         115                 120                 125            
 Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn Glu
     130                 135                 140                
 Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp Ile
 145                 150                 155                 160
 Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile Gln
                 165                 170                 175    
 His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln Glu
             180                 185                 190        
 Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys Pro
         195                 200                 205            
 Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser Ser
     210                 215                 220                
 Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln Lys
 225                 230                 235                 240
 Cys Thr Val Ala Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu Phe
                 245                 250                 255    
 Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu Ile
             260                 265                 270        
 Ser Lys Tyr Leu Thr Phe Leu Leu Val Val Thr Ile Leu Ile Val Val
         275                 280                 285            
 Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr His
     290                 295                 300                
 Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro Gln
 305                 310                 315                 320
 Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln Asp
                 325                 330                 335    
 Thr Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Thr Thr
             340                 345                 350        
 Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe Gln
         355                 360                 365            
 Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu Glu
     370                 375                 380                
 Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys Gln
 385                 390                 395                 400
 Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile Ala
                 405                 410                 415    
 Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu Trp
             420                 425                 430        
 Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met Leu
         435                 440                 445            
 Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu Met Ala His Tyr
     450                 455                 460                
 Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr Leu
 465                 470                 475                 480
 Pro Ser Pro Asp
                



      <210> 888
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 888
 Met Ala Asn Pro Gly Gly Gly Ala Val Cys Asn Gly Lys Leu His Asn
   1               5                  10                  15    
 His Lys Lys Gln Ser Asn Gly Ser Gln Ser Arg Asn Cys Thr Lys Asn
              20                  25                  30        
 Gly Ile Val Lys Glu Ala Gln Gln Asn Gly Lys Pro His Phe Tyr Asp
          35                  40                  45            
 Lys Leu Ile Val Glu Ser Phe Glu Glu Ala Pro Leu His Val Met Val
      50                  55                  60                
 Phe Thr Tyr Met Gly Tyr Gly Ile Gly Thr Leu Phe Gly Tyr Leu Arg
  65                  70                  75                  80
 Asp Phe Leu Arg Asn Trp Gly Ile Glu Lys Cys Asn Ala Ala Val Glu
                  85                  90                  95    
 Arg Lys Glu Gln Lys Val Arg Met Arg Thr Ser Leu Asp Leu Cys Gln
             100                 105                 110        
 Cys Leu Leu Leu Ser Lys Val Phe Ser Glu Val Val Met Gln Val Gln
         115                 120                 125            
 Ile Leu Glu Ser Met Arg Cys Ser Gly Thr Ile Gln Gly Lys Phe His
     130                 135                 140                
 Ser Ser Pro Pro Ala Lys Pro His Tyr Pro Trp Ala Tyr Gly Pro Val
 145                 150                 155                 160
 Phe Thr Asn Ile Ser Trp Ala Thr Thr Ile Cys His Ile Pro Asn
                 165                 170                 175



      <210> 889
      <211> 686
      <212> PRT
      <213> Homo sapiens


      <400> 889
 Met Lys Pro Pro Phe Leu Leu Ala Leu Val Val Cys Ser Val Val Ser
   1               5                  10                  15    
 Thr Asn Leu Lys Met Val Ser Lys Arg Asn Ser Val Asp Gly Cys Ile
              20                  25                  30        
 Asp Trp Ser Val Asp Leu Lys Thr Tyr Met Ala Leu Ala Gly Glu Pro
          35                  40                  45            
 Val Arg Val Lys Cys Ala Leu Phe Tyr Ser Tyr Ile Arg Thr Asn Tyr
      50                  55                  60                
 Ser Thr Ala Gln Ser Thr Gly Leu Arg Leu Met Trp Tyr Lys Asn Lys
  65                  70                  75                  80
 Gly Asp Leu Glu Glu Pro Ile Ile Phe Ser Glu Val Arg Met Ser Lys
                  85                  90                  95    
 Glu Glu Asp Ser Ile Trp Phe His Ser Ala Glu Ala Gln Asp Ser Gly
             100                 105                 110        
 Phe Tyr Thr Cys Val Leu Arg Asn Ser Thr Tyr Cys Met Lys Val Ser
         115                 120                 125            
 Met Ser Leu Thr Val Ala Glu Asn Glu Ser Gly Leu Cys Tyr Asn Ser
     130                 135                 140                
 Arg Ile Arg Tyr Leu Glu Lys Ser Glu Val Thr Lys Arg Lys Glu Ile
 145                 150                 155                 160
 Ser Cys Pro Asp Met Asp Asp Phe Lys Lys Ser Asp Gln Glu Pro Asp
                 165                 170                 175    
 Val Val Trp Tyr Lys Glu Cys Lys Pro Lys Met Trp Arg Ser Ile Ile
             180                 185                 190        
 Ile Gln Lys Gly Asn Ala Leu Leu Ile Gln Glu Val Gln Glu Glu Asp
         195                 200                 205            
 Gly Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Glu Gly Lys Leu Val Arg
     210                 215                 220                
 Arg Thr Thr Glu Leu Lys Val Thr Ala Leu Leu Thr Asp Lys Pro Pro
 225                 230                 235                 240
 Lys Pro Leu Phe Pro Met Glu Asn Gln Pro Ser Val Ile Asp Val Gln
                 245                 250                 255    
 Leu Gly Lys Pro Leu Asn Ile Pro Cys Lys Ala Phe Phe Gly Phe Ser
             260                 265                 270        
 Gly Glu Ser Gly Pro Met Ile Tyr Trp Met Lys Gly Glu Lys Phe Ile
         275                 280                 285            
 Glu Glu Leu Ala Gly His Ile Arg Glu Gly Glu Ile Arg Leu Leu Lys
     290                 295                 300                
 Glu His Leu Gly Glu Lys Glu Val Glu Leu Ala Leu Ile Phe Asp Ser
 305                 310                 315                 320
 Val Val Glu Ala Asp Leu Ala Asn Tyr Thr Cys His Val Glu Asn Arg
                 325                 330                 335    
 Asn Gly Arg Lys His Ala Ser Val Leu Leu Arg Lys Lys Asp Leu Ile
             340                 345                 350        
 Tyr Lys Ile Glu Leu Ala Gly Gly Leu Gly Ala Ile Phe Leu Leu Leu
         355                 360                 365            
 Val Leu Leu Val Val Ile Tyr Lys Cys Tyr Asn Ile Glu Leu Met Leu
     370                 375                 380                
 Phe Tyr Arg Gln His Phe Gly Ala Asp Glu Thr Asn Asp Asp Asn Lys
 385                 390                 395                 400
 Glu Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Gln Asp Thr Leu
                 405                 410                 415    
 Asp Cys Asp Asn Pro Glu Glu Glu Gln Phe Ala Leu Glu Val Leu Pro
             420                 425                 430        
 Asp Val Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile Pro Glu Arg
         435                 440                 445            
 Asp Leu Ile Pro Ser Gly Thr Tyr Met Glu Asp Leu Thr Arg Tyr Val
     450                 455                 460                
 Glu Gln Ser Arg Arg Leu Ile Ile Val Leu Thr Pro Asp Tyr Ile Leu
 465                 470                 475                 480
 Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Ser Arg Leu His Asn Met
                 485                 490                 495    
 Leu Val Ser Gly Glu Ile Lys Val Ile Leu Ile Glu Cys Thr Glu Leu
             500                 505                 510        
 Lys Gly Lys Val Asn Cys Gln Glu Val Glu Ser Leu Lys Arg Ser Ile
         515                 520                 525            
 Lys Leu Leu Ser Leu Ile Lys Trp Lys Gly Ser Lys Ser Ser Lys Leu
     530                 535                 540                
 Asn Ser Lys Phe Trp Lys His Leu Val Tyr Glu Met Pro Ile Lys Lys
 545                 550                 555                 560
 Lys Glu Met Leu Pro Arg Cys His Val Leu Asp Ser Ala Glu Gln Gly
                 565                 570                 575    
 Leu Phe Gly Glu Leu Gln Pro Ile Pro Ser Ile Ala Met Thr Ser Thr
             580                 585                 590        
 Ser Ala Thr Leu Val Ser Ser Gln Ala Asp Leu Pro Glu Phe His Pro
         595                 600                 605            
 Ser Asp Ser Met Gln Ile Arg His Cys Cys Arg Gly Tyr Lys His Glu
     610                 615                 620                
 Ile Pro Ala Thr Thr Leu Pro Val Pro Ser Leu Gly Asn His His Thr
 625                 630                 635                 640
 Tyr Cys Asn Leu Pro Leu Thr Leu Leu Asn Gly Gln Leu Pro Leu Asn
                 645                 650                 655    
 Asn Thr Leu Lys Asp Thr Gln Glu Phe His Arg Asn Ser Ser Leu Leu
             660                 665                 670        
 Pro Leu Ser Ser Lys Glu Leu Ser Phe Thr Ser Asp Ile Trp
         675                 680                 685    



      <210> 890
      <211> 469
      <212> PRT
      <213> Homo sapiens


      <400> 890
 Met Gln Met Ala Asp Ala Ala Thr Ile Ala Thr Met Asn Lys Ala Ala
   1               5                  10                  15    
 Gly Gly Asp Lys Leu Ala Glu Leu Phe Ser Leu Val Pro Asp Leu Leu
              20                  25                  30        
 Glu Ala Ala Asn Thr Ser Gly Asn Ala Ser Leu Gln Leu Pro Asp Leu
          35                  40                  45            
 Trp Trp Glu Leu Gly Leu Glu Leu Pro Asp Gly Ala Pro Pro Gly His
      50                  55                  60                
 Pro Pro Gly Ser Gly Gly Ala Glu Ser Ala Asp Thr Glu Ala Arg Val
  65                  70                  75                  80
 Arg Ile Leu Ile Ser Val Val Tyr Trp Val Val Cys Ala Leu Gly Leu
                  85                  90                  95    
 Ala Gly Asn Leu Leu Val Leu Tyr Leu Met Lys Ser Met Gln Gly Trp
             100                 105                 110        
 Arg Lys Ser Ser Ile Asn Leu Phe Val Thr Asn Leu Ala Leu Thr Asp
         115                 120                 125            
 Phe Gln Phe Val Leu Thr Leu Pro Phe Trp Ala Val Glu Asn Ala Leu
     130                 135                 140                
 Asp Phe Lys Trp Pro Phe Gly Lys Ala Met Cys Lys Ile Val Ser Met
 145                 150                 155                 160
 Val Thr Ser Met Asn Met Tyr Ala Ser Val Phe Phe Leu Thr Ala Met
                 165                 170                 175    
 Ser Val Thr Arg Tyr His Ser Val Ala Ser Ala Leu Lys Ser His Arg
             180                 185                 190        
 Thr Arg Gly His Gly Arg Gly Asp Cys Cys Gly Arg Ser Leu Gly Asp
         195                 200                 205            
 Ser Cys Cys Phe Ser Ala Lys Ala Leu Cys Val Trp Ile Trp Ala Leu
     210                 215                 220                
 Ala Ala Leu Ala Ser Leu Pro Ser Ala Ile Phe Ser Thr Thr Val Lys
 225                 230                 235                 240
 Val Met Gly Glu Glu Leu Cys Leu Val Arg Phe Pro Asp Lys Leu Leu
                 245                 250                 255    
 Gly Arg Asp Arg Gln Phe Trp Leu Gly Leu Tyr His Ser Gln Lys Val
             260                 265                 270        
 Leu Leu Gly Phe Val Leu Pro Leu Gly Ile Ile Ile Leu Cys Tyr Leu
         275                 280                 285            
 Leu Leu Val Arg Phe Ile Ala Asp Arg Arg Ala Ala Gly Thr Lys Gly
     290                 295                 300                
 Gly Ala Ala Val Ala Gly Gly Arg Pro Thr Gly Ala Ser Ala Arg Arg
 305                 310                 315                 320
 Leu Ser Lys Val Thr Lys Ser Val Thr Ile Val Val Leu Ser Phe Phe
                 325                 330                 335    
 Leu Cys Trp Leu Pro Asn Gln Ala Leu Thr Thr Trp Ser Ile Leu Ile
             340                 345                 350        
 Lys Phe Asn Ala Val Pro Phe Ser Gln Glu Tyr Phe Leu Cys Gln Val
         355                 360                 365            
 Tyr Ala Phe Pro Val Ser Val Cys Leu Ala His Ser Asn Ser Cys Leu
     370                 375                 380                
 Asn Pro Val Leu Tyr Cys Leu Val Arg Arg Glu Phe Arg Lys Ala Leu
 385                 390                 395                 400
 Lys Ser Leu Leu Trp Arg Ile Ala Ser Pro Ser Ile Thr Ser Met Arg
                 405                 410                 415    
 Pro Phe Thr Ala Thr Thr Lys Pro Glu His Glu Asp Gln Gly Leu Gln
             420                 425                 430        
 Ala Pro Ala Pro Pro His Ala Ala Ala Glu Pro Asp Leu Leu Tyr Tyr
         435                 440                 445            
 Pro Pro Gly Val Val Val Tyr Ser Gly Gly Arg Tyr Asp Leu Leu Pro
     450                 455                 460                
 Ser Ser Ser Ala Tyr
 465                



      <210> 891
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 891
 Met Lys Phe Leu Leu Ile Ser Leu Ala Leu Trp Leu Gly Thr Gly Gly
   1               5                  10                  15    
 Thr Arg Gly Thr Glu Pro Glu Leu Ile Glu Thr Gln Arg Arg Ser Leu
              20                  25                  30        
 Gln Val Ala Leu Glu Glu Phe His Lys His Pro Pro Val Gln Leu Ala
          35                  40                  45            
 Phe Gln Glu Ile Gly Val Asp Arg Ala Glu Glu Val Leu Phe Ser Ala
      50                  55                  60                
 Gly Thr Phe Val Arg Leu Glu Phe Lys Leu Gln Gln Thr Asn Cys Pro
  65                  70                  75                  80
 Lys Lys Asp Trp Lys Lys Pro Glu Cys Thr Ile Lys Pro Asn Gly Arg
                  85                  90                  95    
 Arg Arg Lys Cys Leu Ala Cys Ile Lys Met Asp Pro Lys Gly Lys Ile
             100                 105                 110        
 Leu Gly Arg Ile Val His Cys Pro Ile Leu Lys Gln Gly Pro Gln Gln
         115                 120                 125            
 Asp Pro Gln Glu Leu Gln Cys Ile Lys Ile Ala Gln Ala Gly Glu Asp
     130                 135                 140                
 Pro His Gly Tyr Phe Leu Pro Gly Gln Phe Ala Phe Ser Arg Ala Leu
 145                 150                 155                 160
 Arg Thr Lys
            



      <210> 892
      <211> 364
      <212> PRT
      <213> Homo sapiens


      <400> 892
 Met Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln
   1               5                  10                  15    
 Ser Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys
              20                  25                  30        
 Gly Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu
          35                  40                  45            
 Leu Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro
      50                  55                  60                
 Arg Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg
  65                  70                  75                  80
 Arg Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val
                  85                  90                  95    
 Gly Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys
             100                 105                 110        
 Thr Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln
         115                 120                 125            
 Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala
     130                 135                 140                
 Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg
 145                 150                 155                 160
 Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp
                 165                 170                 175    
 Gly Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser
             180                 185                 190        
 Leu Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met
         195                 200                 205            
 Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn
     210                 215                 220                
 Ser Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg
 225                 230                 235                 240
 Glu Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr
                 245                 250                 255    
 Ile Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly
             260                 265                 270        
 Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr
         275                 280                 285            
 Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu
     290                 295                 300                
 Thr Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro
 305                 310                 315                 320
 Leu Gln Glu Asp Ala Asp Ile Gln Val Gly Gly Val Arg Ala Gln Leu
                 325                 330                 335    
 Met His Ile Ser Trp Trp Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu
             340                 345                 350        
 Cys Ala Arg Gly Arg Trp Pro Gly Gly Ser Ser Asp
         355                 360                


